JP2011012055A - External composition for skin, containing vitamins - Google Patents
External composition for skin, containing vitamins Download PDFInfo
- Publication number
- JP2011012055A JP2011012055A JP2010123686A JP2010123686A JP2011012055A JP 2011012055 A JP2011012055 A JP 2011012055A JP 2010123686 A JP2010123686 A JP 2010123686A JP 2010123686 A JP2010123686 A JP 2010123686A JP 2011012055 A JP2011012055 A JP 2011012055A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- skin
- hyaluronic acid
- fat
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 229940088594 vitamin Drugs 0.000 title claims description 12
- 229930003231 vitamin Natural products 0.000 title claims description 12
- 235000013343 vitamin Nutrition 0.000 title claims description 12
- 239000011782 vitamin Substances 0.000 title claims description 12
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 89
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 52
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 49
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 45
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 43
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 41
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 41
- 239000011719 vitamin A Substances 0.000 claims abstract description 41
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 38
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 38
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 37
- 229940045997 vitamin a Drugs 0.000 claims abstract description 37
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 27
- 239000011718 vitamin C Substances 0.000 claims abstract description 27
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 25
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 25
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 22
- 239000011709 vitamin E Substances 0.000 claims abstract description 22
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 20
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 20
- 239000011710 vitamin D Substances 0.000 claims abstract description 20
- 229940046009 vitamin E Drugs 0.000 claims abstract description 20
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 18
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 18
- 229940046008 vitamin d Drugs 0.000 claims abstract description 18
- 230000000694 effects Effects 0.000 claims abstract description 17
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 51
- 229920002674 hyaluronan Polymers 0.000 claims description 51
- 229960003160 hyaluronic acid Drugs 0.000 claims description 51
- 238000004519 manufacturing process Methods 0.000 claims description 35
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 20
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 10
- 239000011769 retinyl palmitate Substances 0.000 claims description 10
- 229940108325 retinyl palmitate Drugs 0.000 claims description 10
- 239000011677 pyridoxine Substances 0.000 claims description 9
- 235000008160 pyridoxine Nutrition 0.000 claims description 8
- 235000005282 vitamin D3 Nutrition 0.000 claims description 7
- 239000011647 vitamin D3 Substances 0.000 claims description 7
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 7
- 229940021056 vitamin d3 Drugs 0.000 claims description 7
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical group CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 6
- 229940042585 tocopherol acetate Drugs 0.000 claims description 6
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 6
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 5
- 230000002708 enhancing effect Effects 0.000 claims description 5
- 230000003712 anti-aging effect Effects 0.000 claims description 3
- 230000037394 skin elasticity Effects 0.000 abstract description 7
- 230000009759 skin aging Effects 0.000 abstract description 6
- 210000003491 skin Anatomy 0.000 description 55
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 18
- 239000002537 cosmetic Substances 0.000 description 13
- 238000010790 dilution Methods 0.000 description 13
- 239000012895 dilution Substances 0.000 description 13
- 230000009471 action Effects 0.000 description 12
- 230000001737 promoting effect Effects 0.000 description 11
- -1 nicotinamide compound Chemical class 0.000 description 8
- 230000037303 wrinkles Effects 0.000 description 7
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 6
- 210000001339 epidermal cell Anatomy 0.000 description 6
- 229960004592 isopropanol Drugs 0.000 description 6
- 229930002330 retinoic acid Natural products 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229960003471 retinol Drugs 0.000 description 5
- 235000020944 retinol Nutrition 0.000 description 5
- 239000011607 retinol Substances 0.000 description 5
- 229960001727 tretinoin Drugs 0.000 description 5
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 3
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000004129 EU approved improving agent Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 206010051246 Photodermatosis Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 230000008845 photoaging Effects 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- YWKSINPSASCIMZ-UHFFFAOYSA-N 4,5-dimethyl-4,5-dihydro-1h-imidazole Chemical compound CC1NC=NC1C YWKSINPSASCIMZ-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- DGPNTCACXCHFDI-UHFFFAOYSA-N Hexyl decanoate Chemical compound CCCCCCCCCC(=O)OCCCCCC DGPNTCACXCHFDI-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N Retinaldehyde Chemical compound O=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940100609 all-trans-retinol Drugs 0.000 description 1
- 239000011717 all-trans-retinol Substances 0.000 description 1
- 235000019169 all-trans-retinol Nutrition 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002682 anti-psoriatic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 235000010376 calcium ascorbate Nutrition 0.000 description 1
- 229940047036 calcium ascorbate Drugs 0.000 description 1
- 239000011692 calcium ascorbate Substances 0.000 description 1
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 229940106054 hexyl decanoate Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 150000003903 lactic acid esters Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
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- 230000035699 permeability Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 150000002266 vitamin A derivatives Chemical class 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
【課題】
皮膚の弾力、ハリ、潤いを持たせ、肌荒れ防止・改善作用を奏し、皮膚の老化を予防することのできる皮膚外用組成物を提供することである。
【解決手段】
ビタミンＡ、ビタミンＢ６、ビタミンＣ、ビタミンＤ及びビタミンＥを有効成分として含有することを特徴とする皮膚外用組成物。
【選択図】なし【Task】
An object of the present invention is to provide an external composition for skin, which has skin elasticity, elasticity and moisture, has an effect of preventing and improving rough skin, and can prevent skin aging.
[Solution]
An external composition for skin comprising vitamin A, vitamin B6, vitamin C, vitamin D and vitamin E as active ingredients.
[Selection figure] None
Description
本発明は、高いヒアルロン酸産生作用を有することにより、皮膚の弾力、ハリ、潤いを持たせ、ひいては、肌荒れ防止・改善作用を奏し、皮膚の老化を予防することのできる皮膚外用組成物等に関する。 The present invention relates to a composition for external use of skin, which has a high hyaluronic acid producing action, thereby giving skin elasticity, firmness and moisture, and consequently, preventing and improving rough skin, and preventing skin aging. .
最近、皮膚化粧料や皮膚外用剤の分野において、皮膚細胞を賦活し、皮膚の機能そのものを活性化して、皮膚症状の改善や抗炎症効果又は創傷治癒効果を発揮させるための研究が多くなされている。老化した皮膚では、角層ターン・オーバー速度の低下、皮膚におけるヒアルロン酸の減少により、乾燥しやすくなることで、肌荒れ・かさつき・しわ・たるみ等が生じやすくなり、また、皮膚の厚さが薄くなることや、ハリが消失（弾力性の低下）すること等の皮膚老化現象が認められることが知られている。これらの原因としては、加齢の他に、外的要因、すなわち紫外線曝露、乾燥、酸化等による表皮細胞や真皮線維芽細胞の機能低下、ヒアルロン酸の分解等が考えられている。 Recently, in the field of skin cosmetics and skin external preparations, many studies have been made to activate skin cells and activate the skin function itself to improve skin symptoms and exert anti-inflammatory effects or wound healing effects. Yes. In aged skin, it becomes easy to dry due to a decrease in stratum corneum turnover speed and a decrease in hyaluronic acid in the skin, and it is easy to cause rough skin, roughness, wrinkles, sagging, etc. It is known that skin aging phenomena such as thinning and disappearance of elasticity (decrease in elasticity) are observed. As these causes, in addition to aging, external factors, that is, a decrease in function of epidermal cells and dermal fibroblasts due to exposure to ultraviolet rays, drying, oxidation, etc., degradation of hyaluronic acid, and the like are considered.
そのため、老化した皮膚の改善のために、ヒアルロン酸やコラーゲンを配合した化粧料、保湿作用や皮膜形成作用を有する生薬抽出物または化学合成物質を配合した化粧料、等によって皮膚に潤いや柔軟性をもたせていた。しかし、これらの方法では、皮膚表面の乾燥は改善されるものの効果は一過性であり、充分かつ本質的な改善効果を得ることはできなかった。 Therefore, in order to improve aging skin, the skin is moisturized and softened by cosmetics containing hyaluronic acid and collagen, herbal extracts with moisturizing and film-forming effects, or cosmetics containing chemically synthesized substances. I had it. However, in these methods, although the drying of the skin surface is improved, the effect is transient and a sufficient and essential improvement effect cannot be obtained.
一方で、皮膚自体の皮膚代謝を向上させ、ヒアルロン酸の産生を高めようとする試みもなされている。例えば、ビタミンＡの代謝物であるレチノイン酸は、ビタミンＡの生理活性体の一つであり、表皮細胞や線維芽細胞の増殖促進作用（例えば、非特許文献１参照）、ヒアルロン酸産生促進作用（非特許文献２参照）、角化改善作用（非特許文献３参照）、抗乾癬作用（非特許文献４参照）、抗にきび作用 (非特許文献５参照)、抗しわ作用（例えば、非特許文献６参照）、光老化皮膚改善作用（非特許文献７参照）等、多様な皮膚生理作用を有することが知られている。そのため、米国では、レチノイン酸配合製剤が光老化皮膚改善剤やしわ改善剤として使用されている。 On the other hand, attempts have been made to improve the skin metabolism of the skin itself and increase the production of hyaluronic acid. For example, retinoic acid, which is a metabolite of vitamin A, is one of the physiologically active substances of vitamin A, and has an action of promoting the growth of epidermal cells and fibroblasts (for example, see Non-Patent Document 1), an action of promoting the production of hyaluronic acid. (See Non-patent document 2), keratinization improving action (see Non-patent document 3), anti-psoriatic action (see Non-patent document 4), anti-acne action (see Non-patent document 5), anti-wrinkle action (for example, non-patent document) It is known to have various skin physiological actions such as a photoaging skin improving action (see Non-Patent Document 7). Therefore, in the United States, retinoic acid combination preparations are used as photoaging skin improving agents and wrinkle improving agents.
しかし、レチノイン酸は刺激性が強いという欠点があり、更に、化粧品には配合できない成分でもあるため、レチノイン酸よりは薬理作用は弱いが、刺激性のないレチノールを活用する試みもなされている。例えば、レチノールの生理作用を高めるために、脂肪酸アミド（特許文献１参照）との併用や、ジメチルイミダゾリン（特許文献２参照）との併用による表皮細胞の賦活増強作用が知られている。また、パルミチン酸レチノールとビタミンＤ３の併用、これらに更に、パルミチン酸アスコルビル及び／又はビタミンＥを併用したものが開示され、皮膚の弾性およびしわ改善効果があることが示されている（特許文献３の表３参照）。 However, retinoic acid has the drawback of being strongly irritating, and since it is also a component that cannot be incorporated into cosmetics, attempts have been made to utilize retinol that is less pharmacological than retinoic acid but has no irritation. For example, in order to enhance the physiological action of retinol, an effect of enhancing the activation of epidermal cells by using in combination with a fatty acid amide (see Patent Document 1) or in combination with dimethylimidazoline (see Patent Document 2) is known. In addition, a combination of retinol palmitate and vitamin D3, and those in which ascorbyl palmitate and / or vitamin E are further used are disclosed, and are shown to have an effect of improving skin elasticity and wrinkles (Patent Document 3). Table 3).
ビタミンＡ類以外でも、ビタミンＣ（特許文献４参照）またはビタミンＥ（特許文献５参照）の単独投与で皮膚ヒアルロン酸の産生促進作用が知られている。また、ビタミンＤ３の単独投与で皮膚の弾性およびしわの改善効果が開示されている（特許文献３の表３比較例２参照）。 In addition to vitamins A, it is known that skin hyaluronic acid production is promoted by administration of vitamin C (see Patent Document 4) or vitamin E (see Patent Document 5) alone. Moreover, the effect of improving skin elasticity and wrinkles by single administration of vitamin D3 is disclosed (see Table 3, Comparative Example 2 of Patent Document 3).
なお、ビタミンＢ群については、ヒアルロン酸産生、皮膚弾性又はシワに対する作用は不明であるが、ニコチン酸アミド化合物を含有する皮膚外用組成物に皮膚バリアー機能を有すること（特許文献６参照）、ビタミンＡ酸（レチノイン酸）と水溶性のビタミンＢ６塩酸塩を含有する美白用皮膚外用剤（特許文献７参照）、等が開示されている。 Regarding vitamin B group, hyaluronic acid production, skin elasticity or wrinkle action is unknown, but the skin external composition containing a nicotinamide compound has a skin barrier function (see Patent Document 6), vitamins A whitening skin external preparation (see Patent Document 7) containing A acid (retinoic acid) and water-soluble vitamin B6 hydrochloride is disclosed.
しかしながら、これまでのビタミン類の単剤及び併用技術では、表皮細胞の賦活作用やヒアルロン酸産生促進作用は充分とは言い難いのが現状であった。また、皮膚外用組成物においてビタミンの組合せが表皮細胞のヒアルロン酸産生促進作用を高めるかどうかについては全く知られていない。更に、これまでのビタミン単剤及び併用剤の皮膚外用組成物の抗老化作用は不充分であった。 However, it has been difficult to say that the conventional vitamin single agents and combined technologies have sufficient epidermal cell activation and hyaluronic acid production promoting effects. Moreover, it is not known at all whether the combination of vitamins enhances the hyaluronic acid production promoting action of epidermal cells in an external composition for skin. Furthermore, the anti-aging effect of the composition for external use of the skin of a single vitamin and a combination agent so far has been insufficient.
すなわち、ビタミンＡ、Ｂ６、Ｃ、Ｄ及びＥ類すべてを配合した皮膚外用組成物は知られておらず、かかるビタミンの組み合わせのヒアルロン酸産生、皮膚弾性又はしわ改善効果、すなわち皮膚老化防止効果についても不明であった。更に、脂溶性のビタミンＢ６とＣ、並びに、ビタミンＡ、Ｄ及びＥ類を配合した皮膚外用組成物については記載も示唆もないのが現状であった。 That is, no external composition for skin containing all of vitamins A, B6, C, D and E is known, and hyaluronic acid production, skin elasticity or wrinkle improving effect of such vitamin combination, ie, skin aging prevention effect Was also unknown. Furthermore, there is no description or suggestion about a composition for external use containing fat-soluble vitamins B6 and C and vitamins A, D and E.
本発明の目的は、ヒアルロン酸の産生を促進することにより、皮膚の弾力、ハリ、潤いを持たせ、ひいては、肌荒れ防止・改善作用を奏し、皮膚の老化を予防することのできる皮膚外用組成物等を提供することである。 An object of the present invention is to provide an external composition for skin that can promote the production of hyaluronic acid, thereby providing skin elasticity, elasticity, and moisture, thereby preventing and improving rough skin and preventing skin aging. Etc. is to provide.
本発明者らは、上述の課題を解決するためにビタミンＡの有する表皮細胞のヒアルロン酸産生作用を向上させる手段について鋭意研究した結果、ビタミンＡと、ビタミンＢ６、ビタミンＣ、ビタミンＤ及びビタミンＥを併用することにより、又は、ビタミンＡと、ビタミンＢ６を併用することにより、ビタミンＡのヒアルロン酸産生が著しく促進されること、更にこれらを組み合わせた皮膚のヒアルロン酸産生促進剤を用いて製造した皮膚外用組成物は、皮膚の乾燥、肌荒れ、しわ、はりの消失を改善し、皮膚の老化を予防できることを見出し、本発明を完成するに至った。 In order to solve the above-mentioned problems, the present inventors have conducted intensive research on means for improving the hyaluronic acid producing action of epidermal cells possessed by vitamin A. As a result, vitamin A, vitamin B6, vitamin B6, vitamin C, vitamin D and vitamin E In combination with Vitamin A or Vitamin B6, Vitamin A hyaluronic acid production is remarkably promoted, and further, a hyaluronic acid production promoter for the skin that combines these is produced. The composition for external use of skin has been found to improve the disappearance of dry skin, rough skin, wrinkles, and beams and prevent skin aging, and has completed the present invention.
すなわち、本発明は、以下に記すとおりである。
（１）
ビタミンＡ、ビタミンＢ６、ビタミンＣ、ビタミンＤ及びビタミンＥを有効成分として含有することを特徴とする皮膚外用組成物。
さらに、本発明の好適な態様としては、以下の発明が挙げられる。
（２）
ビタミンＢ６及びビタミンＣが脂溶性ビタミンである、上記（１）に記載の皮膚外用組成物。
（３）
ビタミンＡ及びビタミンＢ６を有効成分として含有することを特徴とする皮膚外用組成物。
（４）
ビタミンＢ６が脂溶性ビタミンである、上記（３）に記載の皮膚外用組成物。
（５）
上記（１）乃至（４）のいずれかに記載の組成物が、老化防止用である皮膚外用組成物。
（６）
ビタミンＡ、脂溶性ビタミンＢ６、脂溶性ビタミンＣ、ビタミンＤ及びビタミンＥからなることを特徴とする皮膚のヒアルロン酸産生促進剤。
（７）
ビタミンＡ、脂溶性ビタミンＣ、ビタミンＤ及びビタミンＥからなる皮膚のヒアルロン酸産生促進剤に、更に、脂溶性のビタミンＢ６を含有することにより、ビタミンＡ、脂溶性ビタミンＣ、ビタミンＤ及びビタミンＥの効果を増強することを特徴とする皮膚のヒアルロン酸産生促進剤。
（８）
ビタミンＡがパルミチン酸レチノールであり、ビタミンＢ６がトリ２−ヘキシルデカン酸ピリドキシンであり、脂溶性ビタミンＣがテトラ２−ヘキシルデカン酸アスコルビルであり、ビタミンＤがコレカルシフェロールであり、ビタミンＥが酢酸トコフェロールである、上記（６）又は（７）に記載の皮膚のヒアルロン酸産生促進剤。
（９）
ビタミンＡからなる皮膚のヒアルロン酸産生促進剤に、更に、脂溶性のビタミンＢ６を含有することにより、ビタミンＡの効果を増強することを特徴とする皮膚のヒアルロン酸産生促進剤。
（１０）
ビタミンＡがパルミチン酸レチノールであり、ビタミンＢ６がトリ２−ヘキシルデカン酸ピリドキシンである、上記（９）に記載の皮膚のヒアルロン酸産生促進剤。
（１１）
上記（６）乃至（１０）のいずれかに記載の組成物が、老化防止用である皮膚のヒアルロン酸産生促進剤。
That is, the present invention is as described below.
(1)
An external composition for skin comprising vitamin A, vitamin B6, vitamin C, vitamin D and vitamin E as active ingredients.
Furthermore, the following invention is mentioned as a suitable aspect of this invention.
(2)
The external composition for skin according to (1) above, wherein vitamin B6 and vitamin C are fat-soluble vitamins.
(3)
An external composition for skin comprising vitamin A and vitamin B6 as active ingredients.
(4)
The external composition for skin according to (3) above, wherein vitamin B6 is a fat-soluble vitamin.
(5)
A composition for external use on skin, wherein the composition according to any one of (1) to (4) is for anti-aging.
(6)
A hyaluronic acid production promoter for skin, comprising vitamin A, fat-soluble vitamin B6, fat-soluble vitamin C, vitamin D, and vitamin E.
(7)
By containing fat-soluble vitamin B6 in the hyaluronic acid production promoter for skin consisting of vitamin A, fat-soluble vitamin C, vitamin D and vitamin E, vitamin A, fat-soluble vitamin C, vitamin D and vitamin E A hyaluronic acid production promoter for skin characterized by enhancing the effect of.
(8)
Vitamin A is retinol palmitate, vitamin B6 is pyridoxine tri-2-hexyldecanoate, fat-soluble vitamin C is ascorbyl tetra-2-hexyldecanoate, vitamin D is cholecalciferol, vitamin E is tocopherol acetate The hyaluronic acid production promoter for skin according to (6) or (7) above.
(9)
A hyaluronic acid production promoter for skin characterized by enhancing the effect of vitamin A by further containing fat-soluble vitamin B6 in the hyaluronic acid production promoter for skin comprising vitamin A.
(10)
The hyaluronic acid production promoter for skin according to (9) above, wherein vitamin A is retinol palmitate and vitamin B6 is pyridoxine tri-2-hexyldecanoate.
(11)
A hyaluronic acid production promoter for skin, wherein the composition according to any one of (6) to (10) above is used for preventing aging.
本発明により、これまでのビタミンＡ単剤製剤等に較べて、著しく優れた皮膚ヒアルロン酸産生促進作用を有する皮膚外用組成物又は化粧料が得られた。これにより、皮膚に弾性、シワ、ハリ、潤いを持たせ、ひいては、皮膚の老化が予防できるため有用である。 According to the present invention, a composition for external use for skin or a cosmetic having a remarkably superior action for promoting the production of skin hyaluronic acid as compared with conventional vitamin A single preparations and the like was obtained. This makes the skin elastic, wrinkled, firm and moisturized, which is useful because it can prevent aging of the skin.
各群の成分は、１）無処置（Humedia-KB2）、２）コントロール（0.1% 2プロパノール含有Humedia-KB2）、３）ＶＢ６（100倍希釈）、４）ＶＢ６（10倍希釈）、５）ＶＢ６、６）ＶＡ＋ＶＣ＋ＶＤ＋ＶＥ（100倍希釈）、７）ＶＡ＋ＶＣ＋ＶＤ＋ＶＥ（10倍希釈）、８）ＶＡ＋ＶＣ＋ＶＤ＋ＶＥ、９）ＶＡ＋ＶＢ６＋ＶＣ＋ＶＤ＋ＶＥ（100倍希釈）、１０）ＶＡ＋ＶＢ６＋ＶＣ＋ＶＤ＋ＶＥ（10倍希釈）、１１）ＶＡ＋ＶＢ６＋ＶＣ＋ＶＤ＋ＶＥである。 The components of each group are 1) No treatment (Humedia-KB2), 2) Control (Humedia-KB2 containing 0.1% 2 propanol), 3) VB6 (100-fold dilution), 4) VB6 (10-fold dilution), 5) VB6, 6) VA + VC + VD + VE (100-fold dilution), 7) VA + VC + VD + VE (10-fold dilution), 8) VA + VC + VD + VE, 9) VA + VB6 + VC + VD + VE (100-fold dilution), 10) VA + VB6 + VC + V + V + V + V + V + V + V + V + V + V + V + V + V + V + V + V + V + V +
各群の成分は、１）無処置（Humedia-KB2）、２）コントロール（0.1% 2プロパノール含有Humedia-KB2）、３）ＶＡ（100倍希釈）、４）ＶＡ（10倍希釈）、５）ＶＡ、６）ＶＢ６（100倍希釈）、７）ＶＢ６（10倍希釈）、８）ＶＢ６、９）ＶＡ＋ＶＢ６（100倍希釈）、１３）ＶＡ＋ＶＢ６（10倍希釈）、１４）ＶＡ＋ＶＢ６である。 The components of each group are 1) No treatment (Humedia-KB2), 2) Control (Humedia-KB2 containing 0.1% 2 propanol), 3) VA (100-fold dilution), 4) VA (10-fold dilution), 5) VA, 6) VB6 (100-fold dilution), 7) VB6 (10-fold dilution), 8) VB6, 9) VA + VB6 (100-fold dilution), 13) VA + VB6 (10-fold dilution), 14) VA + VB6.
本発明に用いられる「ビタミンＡ」は、例えば、レチノール；レチノールのパルミチン酸エステル、ステアリン酸エステル、酢酸エステル等の各種脂肪酸エステル；レチノールの乳酸エステル、グリコール酸エステル等の各種有機酸エステル；レチノールのリン酸、ピロリン酸、硫酸等の各種無機酸ジエステル複合体等が挙げられる。好適には、オール−ｔｒａｎｓ−レチノールおよびその異性体、オール−ｔｒａｎｓ―レチノイン酸およびその異性体、オール−ｔｒａｎｓ―レチナールおよびその異性体、それらの３デヒドロ体、３，４ジデヒドロ体、さらには、広く市販されており、安定性が比較的良好なパルミチン酸レチノールが挙げられる。特に好適には、パルミチン酸レチノールである。これらのビタミンＡは、合成によって得られたものであっても、天然抽出物より得られたものであっても、それを精製したものであっても良い。 “Vitamin A” used in the present invention includes, for example, retinol; various fatty acid esters such as palmitic acid ester, stearic acid ester and acetic acid ester of retinol; various organic acid esters such as lactic acid ester and glycolic acid ester of retinol; Examples include various inorganic acid diester complexes such as phosphoric acid, pyrophosphoric acid, and sulfuric acid. Preferably, all-trans-retinol and its isomers, all-trans-retinoic acid and its isomers, all-trans-retinal and its isomers, their 3 dehydro, 3,4 didehydro, Examples thereof include retinol palmitate, which is widely marketed and has relatively good stability. Particularly preferred is retinol palmitate. These vitamin A may be obtained by synthesis, may be obtained from a natural extract, or may be obtained by purifying it.
本発明に用いられる「ビタミンＢ６」は、例えば、ピリドキシン、塩酸ピリドキシン、トリ２−ヘキシルデカン酸ピリドキシン等が挙げられるが、本発明における「ビタミンＢ６」としては、「脂溶性ビタミンＢ６」が、角質浸透性ひいてはヒアルロン酸産生促進の効果の面から好ましい。本発明に用いられる「脂溶性ビタミンＢ６」は、脂溶性のビタミンＢ６であれば特に限定されないが、例えば、トリ２−ヘキシルデカン酸ピリドキシンが好適に挙げられる。これらのビタミンＢ６は、合成により得られたものであっても、天然抽出物より得られたものであっても、それを精製したものであっても良い。 Examples of “vitamin B6” used in the present invention include pyridoxine, pyridoxine hydrochloride, pyridoxine tri-2-hexyldecanoate, etc. As “vitamin B6” in the present invention, “fat-soluble vitamin B6” This is preferable from the viewpoint of the effect of promoting hyaluronic acid production. “Fat-soluble vitamin B6” used in the present invention is not particularly limited as long as it is fat-soluble vitamin B6, and for example, pyridoxine tri-2-hexyldecanoate is preferably exemplified. These vitamin B6 may be obtained by synthesis, may be obtained from a natural extract, or may be obtained by purifying it.
本発明に用いられる「ビタミンＣ」は、例えば、アスコルビン酸、アスコルビン酸カルシウム、アスコルビン酸ナトリウム、パルミチン酸アスコルビル、テトラ２−ヘキシルデカン酸アスコルビル等が挙げられるが、本発明における「ビタミンＣ」としては、「脂溶性ビタミンＣ」の方が、角質浸透性ひいてはヒアルロン酸産生促進の効果の面から好ましい。本発明に用いられる「脂溶性ビタミンＣ」は、脂溶性のビタミンＣであれば特に限定されないが、例えば、パルミチン酸アスコルビル、テトラ２−ヘキシルデカン酸アスコルビル等が好適に挙げられる。これらのビタミンＣは、合成により得られたものであっても、天然抽出物より得られたものであっても、それを精製したものであっても良い。 Examples of the “vitamin C” used in the present invention include ascorbic acid, calcium ascorbate, sodium ascorbate, ascorbyl palmitate, ascorbyl tetra-2-hexyldecanoate, etc. As “vitamin C” in the present invention, “Fat-soluble vitamin C” is preferred from the viewpoint of the effect of promoting keratin permeability and hence hyaluronic acid production. The “fat-soluble vitamin C” used in the present invention is not particularly limited as long as it is fat-soluble vitamin C. For example, ascorbyl palmitate, ascorbyl tetra-2-hexyldecanoate and the like are preferably mentioned. These vitamin Cs may be those obtained by synthesis, those obtained from natural extracts, or those obtained by purifying them.
本発明に用いられる「ビタミンＤ」及び「ビタミンＥ」は、例えば、コレカルシフェロール、エルゴカルシフェロール；トコフェロール、コハク酸トコフェロール、酢酸トコフェロール等が挙げられ、コレカルシフェロール及び酢酸トコフェロールが好適に挙げられる。 Examples of “vitamin D” and “vitamin E” used in the present invention include cholecalciferol, ergocalciferol; tocopherol, tocopherol succinate, tocopherol acetate and the like, and cholecalciferol and tocopherol acetate are preferably mentioned. .
本発明の「皮膚のヒアルロン酸産生促進剤」とは、ビタミンＡ、ビタミンＢ６、ビタミンＣ、ビタミンＤ及びビタミンＥからなることによって皮膚のヒアルロン酸産生を促進させる剤である。本剤を皮膚外用組成物（医療用のみではなく、化粧用組成物も含む）に含有させることによって、本剤の効果を有する皮膚外用組成物を製造することができる。 The “skin hyaluronic acid production promoter” of the present invention is an agent that promotes skin hyaluronic acid production by comprising vitamin A, vitamin B6, vitamin C, vitamin D, and vitamin E. By including this agent in an external composition for skin (not only for medical use but also for cosmetics), a composition for external skin having the effect of this agent can be produced.
本発明の「皮膚外用組成物」は、皮膚に塗布して用いられる組成物であれば特に限定はないが、例えば、医療用の皮膚外用組成物又は化粧料組成物である。本組成物には、ビタミンＡ、脂溶性ビタミンＢ６、脂溶性ビタミンＣ、ビタミンＤ及びビタミンＥ等の有効成分以外に、通常、医薬品、医薬部外品、化粧品などの皮膚外用医療用組成物に用いられる成分、例えば、水性成分、油性成分、粉末成分、アルコール類、保湿剤、増粘剤、紫外線吸収剤、美白剤、防腐剤、酸化防止剤、界面活性剤、香料、色素などを適宜必要に応じて配合することができる。そのような配合の方法は、日局製剤総則に記載の方法に従って行うことができる。 The “external skin composition” of the present invention is not particularly limited as long as it is a composition used by being applied to the skin. For example, it is a medical external skin composition or cosmetic composition. In addition to active ingredients such as vitamin A, fat-soluble vitamin B6, fat-soluble vitamin C, vitamin D, and vitamin E, this composition is usually used as a medical composition for external skin use such as pharmaceuticals, quasi-drugs, and cosmetics. Necessary components such as aqueous components, oily components, powder components, alcohols, humectants, thickeners, UV absorbers, whitening agents, preservatives, antioxidants, surfactants, fragrances, pigments, etc. It can be blended according to. Such a blending method can be performed according to the method described in the Japanese Pharmacopoeia General Rules.
本発明の皮膚外用組成物の「剤型」としては、皮膚に適用できる剤型であれば特に限定されないが、クリーム剤、軟膏剤、液剤、ゲル剤、ローション剤などの塗布剤、パップ剤、テープ剤、パッチ剤などの貼付剤などが好適である。 本発明の皮膚外用組成物はまた、例えば、医薬品、医薬部外品、化粧品などとして利用することができ、これを1日1〜数回皮膚に塗布すればよい。 The “dosage form” of the external composition for skin of the present invention is not particularly limited as long as it is a dosage form that can be applied to the skin, but it is a coating agent such as a cream, ointment, liquid, gel, or lotion, a poultice, Tapes and patches such as patches are suitable. The composition for external use of the skin of the present invention can also be used as, for example, a pharmaceutical product, a quasi-drug, a cosmetic product, etc., and may be applied to the skin once to several times a day.
本発明の実施例を以下に記載するが、これらに限定されるものではない。 Examples of the present invention are described below, but are not limited thereto.
（実施例１）美容液
表１に記載の成分を、混合し美容液を製造した。
(Example 1) Cosmetic liquid The ingredients listed in Table 1 were mixed to produce a cosmetic liquid.
（実施例２）美容液
表２に記載の成分を、混合し美容液を製造した。
(Example 2) Cosmetic liquid The ingredients listed in Table 2 were mixed to produce a cosmetic liquid.
（実施例３）クリーム
表３に記載の成分を、混合しクリームを製造した。
(Example 3) Cream The ingredients listed in Table 3 were mixed to produce a cream.
（実施例４）乳液
表４に記載の成分を、混合し乳液を製造した。
(Example 4) Emulsion The ingredients listed in Table 4 were mixed to produce an emulsion.
（試験例１）ヒト表皮角化細胞におけるヒアルロン酸量測定１
ビタミン類は、２−プロパノールで１０００倍濃度に調製した後、培地中に０．１％添加した。すなわち、９６穴プレートに正常ヒト表皮角化細胞（クラボウ）をHuMedia KG-2培地（クラボウ）にて１０，０００ｃｅｌｌｓ／ｗｅｌｌの密度で播種し、１日後、ビタミンＢ６のみ、ＶＡ＋ＶＣ＋ＶＤ＋ＶＥおよびＶＡ＋ＶＢ６＋ＶＣ＋ＶＤ＋ＶＥを表５に記載の濃度及びそれらの１０倍希釈液及び１００倍希釈液を添加したHuMedia KB-2培地（クラボウ）と交換した。なお、コントロールは媒体の０．１％２−プロパノールとした。被験物質添加より２日後に培地を採取し、培地中に分泌されたヒアルロン酸濃度を、ヒアルロン酸測定キット（生化学バイオビジネス株式会社）を用いて定量した。結果を表６及び図１に示した。なお、データは各群４例の平均値である。
(Test Example 1) Measurement of hyaluronic acid content in human keratinocytes 1
Vitamins were adjusted to a 1000-fold concentration with 2-propanol and then added to the medium at 0.1%. That is, normal human epidermal keratinocytes (Kurabo) were seeded in a 96-well plate at a density of 10,000 cells / well in HuMedia KG-2 medium (Kurabo). One day later, vitamin B6 alone, VA + VC + VD + VE and VA + VB6 + VC + VD + VE And the HuMedia KB-2 medium (Kurabo) supplemented with 10-fold and 100-fold dilutions thereof. The control was 0.1% 2-propanol as a medium. Two days after the addition of the test substance, the medium was collected, and the hyaluronic acid concentration secreted into the medium was quantified using a hyaluronic acid measurement kit (Seikagaku Biobusiness Co., Ltd.). The results are shown in Table 6 and FIG. The data is an average value of 4 cases in each group.
表６及び図１の結果より、ビタミンＡ、ビタミンＣ、ビタミンＤ、ビタミンＥの組み合わせの場合と比較して、これにビタミンＢ６を加えた方が、ヒアルロン酸濃度が高く、優れたヒアルロン酸産生促進効果を有することが明らかとなった。 From the results of Table 6 and FIG. 1, compared to the combination of vitamin A, vitamin C, vitamin D, and vitamin E, the addition of vitamin B6 to this has a higher hyaluronic acid concentration and superior hyaluronic acid production It became clear that it had a promoting effect.
（試験例２）ヒト表皮角化細胞におけるヒアルロン酸量測定２
ビタミン類は、２−プロパノールで１０００倍濃度に調製した後、培地中に０．１％添加した。すなわち、９６穴プレートに正常ヒト表皮角化細胞（クラボウ）をHuMedia KG-2培地（クラボウ）にて１０，０００ｃｅｌｌｓ／ｗｅｌｌの密度で播種し、１日後、ビタミンＡのみ、ビタミンＢ６のみ、およびＶＡ＋ＶＢ６を表５に記載の濃度及びそれらの１０倍希釈液及び１００倍希釈液を添加したHuMedia KB-2培地（クラボウ）と交換した。なお、コントロールは媒体の０．１％２−プロパノールとした。被験物質添加より２日後に培地を採取し、培地中に分泌されたヒアルロン酸濃度を、ヒアルロン酸測定キット（生化学バイオビジネス株式会社）を用いて定量した。これらの結果を表７及び図２に示した。なお、データは各群４例の平均値である。
(Test Example 2) Measurement of hyaluronic acid content in human epidermal keratinocytes 2
Vitamins were adjusted to a 1000-fold concentration with 2-propanol and then added to the medium at 0.1%. That is, normal human epidermal keratinocytes (Kurabo) were seeded in a 96-well plate in a HuMedia KG-2 medium (Kurabo) at a density of 10,000 cells / well, and one day later, vitamin A only, vitamin B6 only, and VA + VB6 Were replaced with HuMedia KB-2 medium (Kurabo) supplemented with the concentrations shown in Table 5 and 10-fold and 100-fold dilutions thereof. The control was 0.1% 2-propanol as a medium. Two days after the addition of the test substance, the medium was collected, and the hyaluronic acid concentration secreted into the medium was quantified using a hyaluronic acid measurement kit (Seikagaku Biobusiness Co., Ltd.). These results are shown in Table 7 and FIG. The data is an average value of 4 cases in each group.
表７及び図２の結果より、ビタミンＡ単独の場合と比較して、それにビタミンＢ６を添加した方が優れたヒアルロン酸産生促進効果を有することが明らかとなった。
From the results in Table 7 and FIG. 2, it was revealed that the addition of vitamin B6 to the vitamin A alone has an excellent hyaluronic acid production promoting effect as compared with the case of vitamin A alone.
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| JP2019081718A (en) * | 2017-10-30 | 2019-05-30 | 日光ケミカルズ株式会社 | Hyaluronan synthase expression enhancer |
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