JP2010540636A5 - - Google Patents
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- JP2010540636A5 JP2010540636A5 JP2010527993A JP2010527993A JP2010540636A5 JP 2010540636 A5 JP2010540636 A5 JP 2010540636A5 JP 2010527993 A JP2010527993 A JP 2010527993A JP 2010527993 A JP2010527993 A JP 2010527993A JP 2010540636 A5 JP2010540636 A5 JP 2010540636A5
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- Prior art keywords
- composition
- animal
- cognitive function
- amount effective
- enhance
- Prior art date
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- 230000003920 cognitive function Effects 0.000 claims 10
- 230000002708 enhancing Effects 0.000 claims 10
- 229940057917 Medium chain triglycerides Drugs 0.000 claims 8
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 8
- 239000003963 antioxidant agent Substances 0.000 claims 4
- 235000019156 vitamin B Nutrition 0.000 claims 4
- 239000011720 vitamin B Substances 0.000 claims 4
- 229930003270 Vitamin B Natural products 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 2
- 230000000111 anti-oxidant Effects 0.000 claims 2
- 230000003078 antioxidant Effects 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 208000000044 Amnesia Diseases 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 206010057668 Cognitive disease Diseases 0.000 claims 1
- 208000003282 Consciousness Disorders Diseases 0.000 claims 1
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 125000000511 arginine group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000000386 athletic Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001149 cognitive Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
Claims (20)
- 動物の認知機能を高めるのに有効な量で、１つ以上の長鎖ポリ不飽和脂肪酸（ＬＣＰＵＦＡ）、１つ以上の中鎖トリグリセリド（ＭＣＴ）及び１つ以上の酸化窒素放出化合物（ＮＯＲＣ）を含む、動物の認知機能を高めるのに適した組成物。
- 前記ＬＣＰＵＦＡが、天然魚油、ＡＬＡ、ＥＰＡ、ＤＰＡ、ＤＨＡ又は任意の源由来の別のｎ−３脂肪酸、の１つ若しくは複数を含む、請求項１に記載の組成物。
- 約０．１％〜約５０％のＬＣＰＵＦＡを含む、請求項１に記載の組成物。
- 前記ＭＣＴが式（式Ｉ）のものである、請求項１に記載の組成物：
（式中、グリセロール骨格にエステル化されたＲ'、Ｒ''及びＲ'''は、５〜１２個の炭素を有する各々独立の脂肪酸である）。 - 約１％〜約３０％のＭＣＴを含む、請求項１に記載の組成物。
- 前記ＮＯＲＣがアルギニン又はその酸化窒素放出誘導体である、請求項１に記載の組成物。
- 約０．１％〜約２０％のＮＯＲＣを含む、請求項１に記載の組成物。
- 認知機能を高めるのに有効な量で、１つ以上のビタミンＢ群を更に含む、請求項１に記載の組成物。
- 推奨１日所要量の約０．１〜４０倍のビタミンＢ群を含む、請求項８に記載の組成物。
- 認知機能を高めるのに有効な量で、１つ以上の抗酸化剤を更に含む、請求項１に記載の組成物。
- 推奨１日所要量の約０．１〜２５倍の抗酸化剤を含む、請求項１０に記載の組成物。
- 認知機能を高めるのに有効な量で、１つ以上のビタミンＢ群及び１つ以上の抗酸化剤を更に含む、請求項１に記載の組成物。
- 推奨１日所要量の約０．１〜４０倍のビタミンＢ群及び推奨１日所要量の約０．１〜２５倍の抗酸化剤を含む、請求項１２に記載の組成物。
- ヒト食品組成物、ペットフード組成物又は栄養補助食品として処方された、請求項１に記載の組成物。
- 認知機能を高めるのに有効な量で、１つ以上の認知に関する薬剤を更に含む、請求項１に記載の組成物。
- 動物の認知機能を高める方法であって、前記動物の認知機能を高めるのに有効な量で、１つ以上の長鎖ポリ不飽和脂肪酸（ＬＣＰＵＦＡ）、１つ以上の中鎖トリグリセリド（ＭＣＴ）及び１つ以上の酸化窒素放出化合物（ＮＯＲＣ）を含む組成物を前記動物に投与することを含む方法。
- 前記動物が加齢動物である、請求項１６に記載の方法。
- 前記動物が加齢に伴う認知障害と関連する表現型を有する、請求項１７に記載の方法。
- 前記表現型が、前記表現型を有さない対照動物と比較したとき、想起力の低下、短期記憶喪失、学習速度の低下、学習能力の低下、問題解決能力の低下、注意持続時間の低下、運動能力の低下、意識障害の増加又は認知症、の１つ若しくは複数を含む、請求項１８に記載の方法。
- 動物の認知機能を高めるのに有効な量で、１つ以上の長鎖ポリ不飽和脂肪酸（ＬＣＰＵＦＡ）、１つ以上の中鎖トリグリセリド（ＭＣＴ）及び１つ以上の酸化窒素放出化合物（ＮＯＲＣ）を前記動物に投与することを含む、動物の認知機能を高めるための方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99766507P | 2007-10-04 | 2007-10-04 | |
| US60/997,665 | 2007-10-04 | ||
| PCT/US2008/011424 WO2009045481A1 (en) | 2007-10-04 | 2008-10-02 | Compositions and methods for enhancing cognitive function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540636A JP2010540636A (ja) | 2010-12-24 |
| JP2010540636A5 true JP2010540636A5 (ja) | 2011-11-17 |
| JP5931337B2 JP5931337B2 (ja) | 2016-06-08 |
Family
ID=40526561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527993A Active JP5931337B2 (ja) | 2007-10-04 | 2008-10-02 | 認知機能を高める組成物及び方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100292330A1 (ja) |
| EP (1) | EP2194781B2 (ja) |
| JP (1) | JP5931337B2 (ja) |
| CN (1) | CN101820754A (ja) |
| AU (3) | AU2008307494B2 (ja) |
| BR (1) | BRPI0818301B1 (ja) |
| CA (1) | CA2701179C (ja) |
| ES (1) | ES2664777T5 (ja) |
| HU (1) | HUE037628T2 (ja) |
| MX (1) | MX2010003568A (ja) |
| NO (1) | NO2194781T3 (ja) |
| PL (1) | PL2194781T5 (ja) |
| RU (1) | RU2507742C2 (ja) |
| TR (1) | TR201807131T4 (ja) |
| WO (1) | WO2009045481A1 (ja) |
| ZA (1) | ZA201003084B (ja) |
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2008
- 2008-10-02 CN CN200880110329A patent/CN101820754A/zh active Pending
- 2008-10-02 NO NO08835957A patent/NO2194781T3/no unknown
- 2008-10-02 WO PCT/US2008/011424 patent/WO2009045481A1/en active Application Filing
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- 2008-10-02 AU AU2008307494A patent/AU2008307494B2/en active Active
- 2008-10-02 JP JP2010527993A patent/JP5931337B2/ja active Active
- 2008-10-02 EP EP08835957.5A patent/EP2194781B2/en active Active
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- 2008-10-02 ES ES08835957T patent/ES2664777T5/es active Active
- 2008-10-02 RU RU2010117221/15A patent/RU2507742C2/ru active
- 2008-10-02 US US12/734,014 patent/US20100292330A1/en not_active Abandoned
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