JP2010538641A - ハイブリッド型誘導放出性媒体 - Google Patents
ハイブリッド型誘導放出性媒体 Download PDFInfo
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Abstract
【解決手段】本発明に係るハイブリッド型誘導放出性媒体は、架橋型の炭水化物ポリマーおよび/またはタンパク質ポリマーを含むゲルと、無機担体と、該無機担体に結合された少なくとも1つの活性成分より構成され、前記活性成分の放出は、ハイブリッド型誘導放出性媒体が外的刺激に接触することにより誘発される。
【選択図】なし
Description
−ポリマーと架橋剤の混合物を提供すること、
−ポリマーを架橋することによりゲルを形成すること、
−無機担体を添加すること、
−少なくとも1つの活性成分を添加すること、
から構成される。
合成方法は、Appl.Catal.,A2005,287(2),183−190に、Cantrellらにより記載された合成方法が適用される。化学物質は、入手したままの状態で使用した。Mg(NO3)2・6H2O、Al(NO3)3・9H2O、(NH4)2CO3、およびNH4OHは、Fluka、Acros、およびJ.T.Bakerから入手した。合成では、Mg対Alのモル比を2:1に仮定した。
65℃におけるMgAl LDH(Mg2Al(OH)6(CO)3)0.5の合成
201.71gの脱塩水中の51.45gのMg(NO3)2・6H2Oおよび37.56gのA1(NO3)3・9H2Oの溶液を、200.37gの脱塩水中の38.7gの(NH4)2CO3と同時に、200mlの脱塩水に、65℃で、撹拌しながら、1時間で滴下して添加した。pHスタットを用いて、35% NH4OH溶液により、pHを7.86で一定に保持した。添加後、撹拌しながら、溶液を65℃でさらに3時間保持した。それに続いて、溶液を濾過してpH7になるまで洗浄し、そして、118℃で18時間乾燥させた。
55℃におけるMgAl LDH(Mg2Al(OH)6(CO)3)0.5の合成
500gの脱塩水中の128.28gのMg(NO3)2・6H2Oおよび94gのA1(NO3)3・9H2Oの150mlの溶液を、500gの脱塩水中の96.20gの(NH4)2CO3の150mlの溶液と同時に、75mlの脱塩水に、55℃で、撹拌しながら、1時間で滴下して添加した。pHスタットを用いて、35% NH4OH溶液により、pHを7.86で一定に保持した。添加後、撹拌しながら、溶液を65℃でさらに3時間保持した。それに続いて、溶液を濾過してpH7になるまで洗浄し、そして、118℃で18時間乾燥させた。
ゲルの合成
1LのH2O中に、14gのNaOHおよび200gのデンプン、グルコースユニットの30%は第一級ヒドロキシル基が酸化されている、を溶解させた。それに続いて、0.65gのNaBH4を添加し、その後、混合物を5分間攪拌した。次に、50mlのグリセロールジグリシジルエーテル架橋剤(Sigma/Aldrichから入手した)を撹拌しながら添加した。30分間撹拌した後、わずかに粘性の溶液を、40℃で一晩置いた。これにより、大きいガスバブルを含有する堅固な(硬質脆性の)薄黄色ゲルを得た。ゲルを押圧して篩(1mm2)に通し、そして、2LのH2O中に4回懸濁させ、そして、5Lのエタノールで沈澱させた。その後、ゲルをエタノールで3回、アセトンで3回洗浄し、次に、空気に晒して乾燥させた。これにより、H2O中の自由膨潤度が15.2g/gである248.3gの乾燥粉末を得た。
ゲルの合成
1LのH2O中に、14gのNaOHおよび200gのPaselli SA2(Avebeから入手したデンプン製品)を溶解させた。それに続いて、0.5gのNaBH4を添加し、その後、混合物を5分間攪拌した。次に、50mlのグリセロールジグリシジルエーテルを撹拌しながら添加した。30分間撹拌した後、ほとんど粘性のない溶液を、40℃で一晩置いた。これにより、大きいガスバブルを含有する堅固な(脆性の)褐色ゲルを得た。ゲルを押圧して篩(1mm2)に通し、その後、黄色塊を2LのH2O中に4回懸濁させ、そして、5Lのエタノールで沈澱させた。その後、ゲルをエタノールで3回、アセトンで3回洗浄し、次に、空気に晒して乾燥させた。これにより、H2O中の自由膨潤度が7.74g/gである233.9gの乾燥粉末を得た。
MgAl LDHを有するゲルの合成
200mlのH2O中の12gの実施例3の乾燥粉末のサスペンジョンを、65℃に昇温して保持した。撹拌しながら、200.02gのH2O中の51.42gのMg(NO3)2・6H2Oおよび37.55gのA1(NO3)3・9H2Oの溶液ならびに200.16gのH2O中の38.21gの(NH4)2CO3の溶液を、0.75時間かけて、ほぼ等しい速度で滴下して添加した。35%のアンモニアでpHを7.6〜8に保持するように試みた。粘性ゲルが得られた。3.4Lの量のH2O中にゲルを懸濁させた。水中のゲルの体積は、徐々にわずかに減少した(30分後に3.1L、1時間後に2.5L、1時間半後に2.3L)。それに続いて、1LのH2Oをデカントにより除去した。次に、体積をH2Oで7Lに増大させた。15分後、2LのH2Oをデカントにより除去した。H2Oの補充と、それに続く撹拌および静止の後、15分後、3LのH2Oをデカントした。それに続いて、H2Oを補充して体積を7Lにし、30分後、3.5Lをデカントした。再度、H2Oを補充して体積を7Lにし、45分後、4Lをデカントした。次に、H2Oを補充して体積を5Lにし、そして、アセトンで7Lの全体積にした。15分後、デカントにより2Lを除去し、その後、アセトンを補充して体積を7Lにした。−20℃のアセトン/氷浴中に20分間入れた後、2Lをデカントし、その後、アセトンを補充して体積を7Lにした。1Lをデカントしてからアセトンを補充して7Lにする処理を2回行った後、サスペンジョンを一晩保持した。次に、5Lをデカントし、その後、アセトンを補充して体積を7Lにした。30分後、3.4Lをデカントした。次に、沈殿をガラスフィルター(細孔サイズ3)上に単離し、そして、アセトンで5回洗浄し、そして暖気中で乾燥させた。これにより、31.96gの粉末を取得し、これを、窒素下、110℃のストーブ内で、さらに乾燥させた。これにより、水中の自由膨潤度が5.50g/gである28.75gの粉末を得た。
MgAl LDHを有するゲルの合成
16gの実施例4の乾燥粉末を使用した以外は、実施例5のときと同様とした。65℃で3時間撹拌した後、反応混合物は、わずかに粘性であった。室温に冷却した後、H2Oを補充して反応混合物を5Lにした。1時間後、4.2LのH2Oをデカントにより除去した。H2Oを補充して体積を5Lにし、その後、4.2Lをデカントした。補充して5Lにした後、サスペンジョンを室温で一晩保持した。次に、4.2Lをデカントし、そして、H2Oを補充して体積を5Lにした。次に、4.2Lをデカントし、その後、アセトンを補充して体積を5Lにした。デカント後、沈殿をアセトンで4回洗浄し、そして、暖気中で乾燥させた。これにより、37.55gの粉末を得た。これを、110℃のストーブ内で、33.96gまでさらに乾燥させた。
インジゴカルミンによるMgAl LDHの交換
0.18gの実施例1のMgAl LDHを、25gのH2Oに、撹拌しながら添加した。次に、6mlの4M HClを、撹拌しながら滴下した。得られた透明溶液に、4mlの35% NH4OHおよび4mlの1%インジゴカルミン溶液を、撹拌しながら、同時に滴下した。得られた白色ディスパージョンを、濾過して、洗浄し、その後、それを、凍結乾燥させた。
インジゴカルミンによるMgAl LDHを有するゲルの交換
1gの実施例5の粉末を、200gのH2Oに、撹拌しながら添加した。次に、6mlの4M HClを滴下した。得られた透明溶液に、2mlの35% NH4OHおよび2mlの1%インジゴカルミン溶液を、撹拌しながら、同時に滴下した。得られた白色ディスパージョンを、濾過して、洗浄し、その後、それを、凍結乾燥させた。
インジゴカルミンによるMgAl LDHを有するゲルの交換
0.53gの実施例6の粉末を、100gのH2Oに、撹拌しながら添加した。次に、6mlの4M HClを滴下した。得られた透明溶液に、2mlの35% NH4OHおよび1mlの1%インジゴカルミン溶液を、撹拌しながら、同時に滴下した。得られた白色ディスパージョンを、濾過して、洗浄し、その後、それを、凍結乾燥させた。
インジゴカルミンによるMgAl LDHの交換
0.53gの実施例1のMgAl LDHを、20gのH2Oに、撹拌しながら添加した。次に、撹拌しながら、6mlの4M HClおよび2mlの1%インジゴカルミン溶液を添加した。混合物を真空下に置き、次に、窒素雰囲気中で保持した。得られた透明溶液に、2mlの35% NH4OHを、撹拌しながら滴下した。1時間撹拌した後、得られた白色ディスパージョンを、濾過し、そして、洗浄し、そして、60℃で乾燥させた。
粒子サイズおよびマトリックス中への吸収
12gの実施例3の乾燥粉末および5gの実施例1または2の無機粒子のサスペンジョンに、水の取込み量が最大になるまで、H2Oを添加した。TEMの結果から、粒子は、大きすぎてゲルマトリックスに浸透できないことが示唆された。
Claims (20)
- 炭水化物ポリマー、タンパク質ポリマー、およびそれらの混合物よりなる群から選択される架橋型バイオポリマーを含むゲルと、無機担体と、該無機担体に結合された少なくとも1つの活性成分より構成され、該活性成分の放出が、媒体が外的刺激に接触することにより誘発される、活性成分放出用のハイブリッド型誘導放出性媒体。
- 最初に、前記ゲルを準備し、次に、前記ゲル中に前記無機担体を導入することにより得られる、請求項1に記載のハイブリッド型誘導放出性媒体。
- 前記無機担体が、スメクタイト、層状複水酸化物、Ag、Au、Fe2O3、MgCl2、AlCl3、ZnCl2、SiO2、TiO2、ZnO、およびMgOよりなる群から選択される無機粒子である、請求項1または2に記載のハイブリッド型誘導放出性媒体。
- 前記無機担体が、前記ゲル中で、前記無機担体をin situで形成する成分の形態で、前記ゲル中に導入される、請求項2に記載のハイブリッド型誘導放出性媒体。
- 前記無機担体が、層状複水酸化物である、請求項4に記載のハイブリッド型誘導放出性媒体。
- 前記無機粒子の平均粒子サイズが、透過型電子顕微鏡観察により測定した場合、2−200nm、5−50nm、又は10−30nmである、前記請求項1から5のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記無機粒子のアスペクト比が、1−500の範囲内である、前記請求項1から6のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記ポリマーが、デンプン、セルロース、ペクチン、ゼラチン、ガム、ならびにそれらの誘導体および/または混合物よりなる群から選択されるバイオポリマーである、前記請求項1から7のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記無機担体が、抗微生物性を有する、前記請求項1から8のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記少なくとも1つの活性成分が、中性および/または疎水性である、前記請求項1から9のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記外的刺激が、前記ポリマーを分解できる酵素である、請求項1から10のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記少なくとも1つの活性成分の放出が、pH変化により生じる静電相互作用により誘発される、前記請求項1から11のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記無機担体への前記少なくとも1つの活性成分の結合が、静電相互作用、水素結合、金属−配位子相互作用、および吸着よりなる群から選択される1つ以上を含む、前記請求項1から12のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記少なくとも1つの活性成分が、抗座瘡剤、脱臭剤、殺菌類剤、悪臭防止成分、抗微生物化合物、細胞静止剤、風味剤、薬剤、園芸用栄養剤、難燃剤、食品添加剤、ペプチドよりなる群から選択されるものである、前期請求項1から13のいずれか1項に記載のハイブリッド型誘導放出性媒体。
- 前記請求項のいずれかのハイブリッド型誘導放出性媒体を作製する方法であって、
−前記ポリマーおよび架橋剤との混合物を準備すること、
−前記ポリマーを架橋することによりゲルを形成すること、
−前記無機担体を添加すること、
−前記少なくとも1つの活性成分を添加すること、
より構成され、該ゲルが形成された後、前記無機担体が添加される、前記媒体の作製方法。 - 前記少なくとも1つの活性成分が、抽出により前記ゲルに充填される、請求項15に記載の方法。
- 請求項1から14のいずれかのハイブリッド型誘導放出性媒体の用途であって、苦味を呈する医薬や栄養医薬の異風味を呈する化合物のマスキング用媒体。
- 請求項1から14のいずれかのハイブリッド型誘導放出性媒体の用途であって、口内での食料の味の変化を供与するための媒体。
- 請求項1から14のいずれかのハイブリッド型誘導放出性媒体の用途であって、フッ化物組成物および/または抗齲蝕化合物の歯保護化合物を口内で放出するための可食性組成物用媒体。
- 請求項1から14のいずれか1項に記載のハイブリッド型誘導放出性媒体を含む、食料。
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EP07116508A EP2039254A1 (en) | 2007-09-14 | 2007-09-14 | Hybrid inducible release vehicle |
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GB201318813D0 (en) * | 2013-10-24 | 2013-12-11 | Univ London Queen Mary | Dental composition |
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WO2007010584A2 (en) * | 2005-07-22 | 2007-01-25 | Gaetano Marenzi | Controlled-delivery system of pharmacologically active substances, preparation process and medical use thereof |
WO2007045953A2 (en) * | 2005-10-18 | 2007-04-26 | Fin-Ceramica Faenza S.P.A. | A composite based on an apatite and an alginate, methods for its preparation and uses as bone substitute |
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WO2007045953A2 (en) * | 2005-10-18 | 2007-04-26 | Fin-Ceramica Faenza S.P.A. | A composite based on an apatite and an alginate, methods for its preparation and uses as bone substitute |
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RU2478303C2 (ru) | 2013-04-10 |
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