JP2010537990A - アルコール中毒および薬物嗜癖の処置のための医薬の組み合わせ - Google Patents
アルコール中毒および薬物嗜癖の処置のための医薬の組み合わせ Download PDFInfo
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| US11351154B2 (en) | 2011-09-09 | 2022-06-07 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| JP7593619B2 (ja) | 2017-09-07 | 2024-12-03 | エヌエルエス－１ ファルマ アーゲー | ヘロイン依存症及び物質使用障害のためのマジンドール治療 |
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| AU2017360910B2 (en) | 2016-11-18 | 2023-11-23 | Aegis Therapeutics, Llc | Compositions and methods for the treatment of opioid overdose |
| WO2018191233A1 (en) * | 2017-04-10 | 2018-10-18 | Curemark, Llc | Compositions for treating addiction |
| CA3071959A1 (en) * | 2017-08-22 | 2019-02-28 | Euphoria Beer Development Ltd | Enriched alcoholic beverages |
| US11160843B2 (en) * | 2018-04-30 | 2021-11-02 | Yale University | Oxytocin and opioid antagonists for treatment of social dysfunction disorder |
| EP3897579A4 (en) * | 2018-12-20 | 2022-11-16 | Aegis Therapeutics, LLC | COMPOSITIONS, DEVICES AND METHODS FOR TREATING OVERDOSE AND REWARD-RELATED DISORDERS |
| RU2721606C1 (ru) * | 2019-11-08 | 2020-05-21 | Общество с ограниченной ответственностью "Ай Кью Витаминная студия" | Фармацевтическая композиция для парентерального капельного введения |
| WO2021154631A1 (en) | 2020-01-30 | 2021-08-05 | Javed Mohammad | Combination drug therapies for cns disorders |
| US20220389509A1 (en) * | 2021-05-25 | 2022-12-08 | Raymond F. Anton | Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in individuals diagnosed with alcohol use disorder |
| US12290596B2 (en) | 2021-08-04 | 2025-05-06 | Indivior Uk Limited | Compositions and methods for the treatment of opioid overdose |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
| WO2025112048A1 (zh) * | 2023-12-01 | 2025-06-05 | 深圳善康医药科技股份有限公司 | 用于防止大麻复吸的药物组合物和其应用 |
| WO2025207125A1 (en) * | 2024-03-26 | 2025-10-02 | The Regents Of The University Of California | Combination pharmacological interventions for obstructive sleep apnea |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007038551A2 (en) * | 2005-09-26 | 2007-04-05 | Avigen, Inc. | Use of ibudilast for treating drug and behavioral addictions |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550021A (en) * | 1990-02-07 | 1996-08-27 | Board Of Regents, The University Of Texas System | Allelic diagnosis of susceptibility to compulsive disorder |
| EP0714663A3 (en) * | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
| US20040167164A1 (en) * | 1998-05-05 | 2004-08-26 | Jose Pozuelo | Compositions and methods for treating particular chemical addictions and mental illnesses |
| US6287765B1 (en) * | 1998-05-20 | 2001-09-11 | Molecular Machines, Inc. | Methods for detecting and identifying single molecules |
| EP1158973B1 (en) * | 1999-02-24 | 2005-05-04 | University Of Cincinnati | Use of sulfamate derivatives for treating impulse control disorders |
| US6740038B2 (en) * | 2000-09-29 | 2004-05-25 | New Health Sciences, Inc. | Systems and methods for assessing vascular effects of a treatment |
| US7122308B2 (en) * | 2001-02-16 | 2006-10-17 | Centre For Addiction And Mental Health | Detection of antidepressant induced mania |
| US7033771B2 (en) * | 2001-05-08 | 2006-04-25 | Takeda Pharmaceutical Company Limited | Use of insulin response modulators in the treatment of diabetes and insulin resistance |
| US20030153590A1 (en) * | 2001-08-14 | 2003-08-14 | Oy Contral Pharma Ltd | Method of treating alcoholism or alcohol abuse |
| EP1434875A4 (en) * | 2001-08-21 | 2004-12-22 | Smithkline Beecham Corp | GENE POLYMORPHISMS AND TREATMENT RESPONSE |
| WO2003037313A2 (en) * | 2001-10-31 | 2003-05-08 | Recovery Pharmaceuticals, Inc. | Methods for the treatment of addiction |
| ES2639579T3 (es) * | 2003-04-29 | 2017-10-27 | Orexigen Therapeutics, Inc. | Composiciones para afectar la pérdida de peso que comprende un antagonista opioide y bupropión |
| GB0316915D0 (en) * | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| US7163969B2 (en) * | 2003-10-14 | 2007-01-16 | Stockhausen, Inc. | Superabsorbent polymer aqueous paste and coating |
| US20050245461A1 (en) * | 2004-03-19 | 2005-11-03 | Elliot Ehrich | Methods for treating alcoholism |
| WO2007039123A2 (en) * | 2005-09-22 | 2007-04-12 | Smithkline Beecham Corporation | Combination therapy comprising an nk-3 antagonist and an antipsychotic agent |
| US20070292880A1 (en) * | 2006-05-05 | 2007-12-20 | Robert Philibert | Compositions and methods for detecting predisposition to a substance use disorder or to a mental illness or syndrome |
| US20080004260A1 (en) * | 2006-06-29 | 2008-01-03 | Transcept Pharmaceuticals, Inc. | Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions |
| US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
| EP2556830A1 (en) * | 2006-12-19 | 2013-02-13 | University Of Virginia Patent Foundation | Combined effects of topiramate, ondansetron and naltrexone on alcohol consumption |
| WO2008095086A2 (en) * | 2007-01-31 | 2008-08-07 | University Of Virginia Patent Foundation | Topiramate plus naltrexone for the treatment of addictive disorders |
| US7844609B2 (en) * | 2007-03-16 | 2010-11-30 | Expanse Networks, Inc. | Attribute combination discovery |
| WO2009026381A2 (en) * | 2007-08-21 | 2009-02-26 | University Of Virginia Patent Foundation | Method, computer program product and system for individual assessment of alcohol sensitivity |
| BRPI0908425B8 (pt) * | 2008-02-28 | 2021-05-25 | Univ Of Virgina Patent Foundation | métodos para predizer uma predisposição para desenvolver alcoolismo, e para predizer uma resposta para o tratamento contra alcoolismo, e, uso de um antagonista do receptor de serotonina 5-ht3 |
| WO2009134944A2 (en) * | 2008-04-29 | 2009-11-05 | Nodality, Inc. | Methods of determining the health status of an individual |
| US20120115149A1 (en) * | 2009-05-01 | 2012-05-10 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of alcoholism |
-
2008
- 2008-05-20 CA CA2697990A patent/CA2697990A1/en not_active Abandoned
- 2008-05-20 JP JP2010522982A patent/JP2010537990A/ja active Pending
- 2008-05-20 WO PCT/US2008/064232 patent/WO2009029308A1/en not_active Ceased
- 2008-05-20 US US12/675,486 patent/US20110065628A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007038551A2 (en) * | 2005-09-26 | 2007-04-05 | Avigen, Inc. | Use of ibudilast for treating drug and behavioral addictions |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10619209B2 (en) | 2008-02-28 | 2020-04-14 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of opioid-related disorders |
| US12221654B2 (en) | 2008-02-28 | 2025-02-11 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of opioid-related disorders |
| US11905562B2 (en) | 2008-02-28 | 2024-02-20 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of opioid-related disorders |
| US8697361B2 (en) | 2008-02-28 | 2014-04-15 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of alcoholism |
| US10533226B2 (en) | 2008-02-28 | 2020-01-14 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of alcoholism |
| US10995374B2 (en) | 2008-02-28 | 2021-05-04 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of opioid-related disorders |
| US11116753B2 (en) | 2010-07-02 | 2021-09-14 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| US10603307B2 (en) | 2010-07-02 | 2020-03-31 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
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| US11324723B2 (en) | 2010-07-02 | 2022-05-10 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
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| US11351154B2 (en) | 2011-09-09 | 2022-06-07 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
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| US20110065628A1 (en) | 2011-03-17 |
| WO2009029308A1 (en) | 2009-03-05 |
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