JP2010537958A - Ｆａｂｐ４／ａｐ２を調節するためのｒｎａアンタゴニスト化合物 - Google Patents
Ｆａｂｐ４／ａｐ２を調節するためのｒｎａアンタゴニスト化合物 Download PDFInfo
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- JP2010537958A JP2010537958A JP2010522397A JP2010522397A JP2010537958A JP 2010537958 A JP2010537958 A JP 2010537958A JP 2010522397 A JP2010522397 A JP 2010522397A JP 2010522397 A JP2010522397 A JP 2010522397A JP 2010537958 A JP2010537958 A JP 2010537958A
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| JP2016526529A (ja) * | 2013-06-16 | 2016-09-05 | 国立大学法人 東京医科歯科大学 | エクソンスキッピング効果を有する二本鎖アンチセンス核酸 |
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| CN102482677B (zh) * | 2009-03-16 | 2017-10-17 | 库尔纳公司 | 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病 |
| ES2585360T3 (es) * | 2009-08-05 | 2016-10-05 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS) |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| WO2015009544A1 (en) * | 2013-07-11 | 2015-01-22 | Texas Heart Institute | Rna interference of fabp4 for the treatment of atherosclerosis |
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| US4962029A (en) * | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US4914210A (en) * | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US6423489B1 (en) * | 1992-09-10 | 2002-07-23 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus-associated diseases |
| JPH08506479A (ja) * | 1992-09-10 | 1996-07-16 | 財団法人化学及血清療法研究所 | Ｃ型肝炎ウイルス関連疾患の治療のための組成物および方法 |
| US6433159B1 (en) * | 1992-09-10 | 2002-08-13 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus associated diseases |
| US5919795A (en) * | 1995-06-07 | 1999-07-06 | Pfizer Inc. | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion |
| WO1998023593A1 (en) * | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
| NZ337703A (en) * | 1997-03-05 | 2001-05-25 | Univ Washington | A screening method to identify agents that selectively inhibit Hepatitis C virus replication in viruses that contain an ISDR region |
| UA79300C2 (en) * | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
| US20050069522A1 (en) * | 2002-08-12 | 2005-03-31 | Richard Colonno | Combination pharmaceutical agents as inhibitors of HCV replication |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| FR2848572B1 (fr) * | 2002-12-12 | 2005-12-09 | Univ Joseph Fourier | Molecules inhibitrices de la synthese proteique du virus de l'hepatite c et procede de criblage desdites molecules inhibitrices |
| DE10300861A1 (de) * | 2003-01-10 | 2004-07-22 | Metagen Pharmaceuticals Gmbh | Verwendung von an FABP4 bindenden Substanzen zur Diagnose und Behandlung des Harnblasenkarzinoms |
| WO2004076614A2 (de) * | 2003-02-27 | 2004-09-10 | Bernd Hinzmann | Humane nukleinsäuresequenzen aus prostatakarzinomen |
| EP1648914A4 (en) * | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA |
| ES2663810T3 (es) * | 2004-08-10 | 2018-04-17 | Kastle Therapeutics, Llc | Métodos para modular los niveles de lipoproteínas y colesterol en humanos |
| CA2666191C (en) * | 2006-10-09 | 2017-07-11 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of pcsk9 |
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- 2008-08-29 JP JP2010522397A patent/JP2010537958A/ja not_active Withdrawn
- 2008-08-29 AU AU2008292091A patent/AU2008292091A1/en not_active Abandoned
- 2008-08-29 WO PCT/EP2008/061432 patent/WO2009027527A2/en not_active Ceased
- 2008-08-29 US US12/675,676 patent/US20110054011A1/en not_active Abandoned
- 2008-08-29 CA CA2697970A patent/CA2697970A1/en not_active Abandoned
- 2008-08-29 EP EP08803420A patent/EP2198024A2/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016526529A (ja) * | 2013-06-16 | 2016-09-05 | 国立大学法人 東京医科歯科大学 | エクソンスキッピング効果を有する二本鎖アンチセンス核酸 |
| US10190117B2 (en) | 2013-06-16 | 2019-01-29 | National University Corporation Tokyo Medical And Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2198024A2 (en) | 2010-06-23 |
| WO2009027527A3 (en) | 2009-07-02 |
| CA2697970A1 (en) | 2009-03-05 |
| WO2009027527A2 (en) | 2009-03-05 |
| US20110054011A1 (en) | 2011-03-03 |
| AU2008292091A1 (en) | 2009-03-05 |
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