CA2697970A1 - Rna antagonist compounds for the modulation of fabp4/ap2 - Google Patents
Rna antagonist compounds for the modulation of fabp4/ap2 Download PDFInfo
- Publication number
- CA2697970A1 CA2697970A1 CA2697970A CA2697970A CA2697970A1 CA 2697970 A1 CA2697970 A1 CA 2697970A1 CA 2697970 A CA2697970 A CA 2697970A CA 2697970 A CA2697970 A CA 2697970A CA 2697970 A1 CA2697970 A1 CA 2697970A1
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- Prior art keywords
- oligomer
- fabp4
- oligomer according
- nucleobases
- lna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C—CHEMISTRY; METALLURGY
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- C12N2310/11—Antisense
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/341—Gapmers, i.e. of the type ===---===
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US96901607P | 2007-08-30 | 2007-08-30 | |
| US60/969,016 | 2007-08-30 | ||
| PCT/EP2008/061432 WO2009027527A2 (en) | 2007-08-30 | 2008-08-29 | Rna antagonist compounds for the modulation of fabp4/ap2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2697970A1 true CA2697970A1 (en) | 2009-03-05 |
Family
ID=40228054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2697970A Abandoned CA2697970A1 (en) | 2007-08-30 | 2008-08-29 | Rna antagonist compounds for the modulation of fabp4/ap2 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110054011A1 (OSRAM) |
| EP (1) | EP2198024A2 (OSRAM) |
| JP (1) | JP2010537958A (OSRAM) |
| AU (1) | AU2008292091A1 (OSRAM) |
| CA (1) | CA2697970A1 (OSRAM) |
| WO (1) | WO2009027527A2 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102482677B (zh) * | 2009-03-16 | 2017-10-17 | 库尔纳公司 | 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病 |
| ES2585360T3 (es) * | 2009-08-05 | 2016-10-05 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS) |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| CA2915443A1 (en) * | 2013-06-16 | 2014-12-24 | National University Corporation Tokyo Medical And Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
| WO2015009544A1 (en) * | 2013-07-11 | 2015-01-22 | Texas Heart Institute | Rna interference of fabp4 for the treatment of atherosclerosis |
Family Cites Families (17)
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| US4962029A (en) * | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US4914210A (en) * | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US6423489B1 (en) * | 1992-09-10 | 2002-07-23 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus-associated diseases |
| JPH08506479A (ja) * | 1992-09-10 | 1996-07-16 | 財団法人化学及血清療法研究所 | Ｃ型肝炎ウイルス関連疾患の治療のための組成物および方法 |
| US6433159B1 (en) * | 1992-09-10 | 2002-08-13 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus associated diseases |
| US5919795A (en) * | 1995-06-07 | 1999-07-06 | Pfizer Inc. | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion |
| WO1998023593A1 (en) * | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
| NZ337703A (en) * | 1997-03-05 | 2001-05-25 | Univ Washington | A screening method to identify agents that selectively inhibit Hepatitis C virus replication in viruses that contain an ISDR region |
| UA79300C2 (en) * | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
| US20050069522A1 (en) * | 2002-08-12 | 2005-03-31 | Richard Colonno | Combination pharmaceutical agents as inhibitors of HCV replication |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| FR2848572B1 (fr) * | 2002-12-12 | 2005-12-09 | Univ Joseph Fourier | Molecules inhibitrices de la synthese proteique du virus de l'hepatite c et procede de criblage desdites molecules inhibitrices |
| DE10300861A1 (de) * | 2003-01-10 | 2004-07-22 | Metagen Pharmaceuticals Gmbh | Verwendung von an FABP4 bindenden Substanzen zur Diagnose und Behandlung des Harnblasenkarzinoms |
| WO2004076614A2 (de) * | 2003-02-27 | 2004-09-10 | Bernd Hinzmann | Humane nukleinsäuresequenzen aus prostatakarzinomen |
| EP1648914A4 (en) * | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA |
| ES2663810T3 (es) * | 2004-08-10 | 2018-04-17 | Kastle Therapeutics, Llc | Métodos para modular los niveles de lipoproteínas y colesterol en humanos |
| CA2666191C (en) * | 2006-10-09 | 2017-07-11 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of pcsk9 |
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Also Published As
| Publication number | Publication date |
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| EP2198024A2 (en) | 2010-06-23 |
| WO2009027527A3 (en) | 2009-07-02 |
| WO2009027527A2 (en) | 2009-03-05 |
| US20110054011A1 (en) | 2011-03-03 |
| AU2008292091A1 (en) | 2009-03-05 |
| JP2010537958A (ja) | 2010-12-09 |
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| FZDE | Discontinued |
Effective date: 20130829 |