JP2010534494A5 - - Google Patents

Info

Publication number

JP2010534494A5

JP2010534494A5 JP2010514904A JP2010514904A JP2010534494A5 JP 2010534494 A5 JP2010534494 A5 JP 2010534494A5 JP 2010514904 A JP2010514904 A JP 2010514904A JP 2010514904 A JP2010514904 A JP 2010514904A JP 2010534494 A5 JP2010534494 A5 JP 2010534494A5

Authority

JP

Japan

Prior art keywords

insulin bolus

patient

information

blood glucose

individual patient

Prior art date

2008-05-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 100
• 102000004877 Insulin Human genes 0.000 claims description 50
• 108090001061 Insulin Proteins 0.000 claims description 50
• 229940125396 insulin Drugs 0.000 claims description 50
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 37
• 239000008103 glucose Substances 0.000 claims description 37
• 235000012054 meals Nutrition 0.000 claims description 33
• 239000008280 blood Substances 0.000 claims description 27
• 210000004369 blood Anatomy 0.000 claims description 27
• 238000000034 method Methods 0.000 claims description 18
• 230000006870 function Effects 0.000 claims description 7
• 235000005911 diet Nutrition 0.000 claims description 4
• 230000037213 diet Effects 0.000 claims description 4
• 230000004044 response Effects 0.000 claims description 4
• 230000035479 physiological effects, processes and functions Effects 0.000 claims description 3
• 238000002560 therapeutic procedure Methods 0.000 claims description 2
• 238000012377 drug delivery Methods 0.000 claims 3
• 238000013507 mapping Methods 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 230000005284 excitation Effects 0.000 description 2
• 230000002641 glycemic effect Effects 0.000 description 2
• 230000006461 physiological response Effects 0.000 description 2
• NOIWEHDTLCFLHV-UHFFFAOYSA-N 2-[2-(dimethylamino)-2-oxoethoxy]benzamide Chemical compound CN(C)C(=O)COC1=CC=CC=C1C(N)=O NOIWEHDTLCFLHV-UHFFFAOYSA-N 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 235000005289 dietary characteristics Nutrition 0.000 description 1
• 238000001647 drug administration Methods 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 239000000700 radioactive tracer Substances 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1