JP2010533497A5 - - Google Patents
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- JP2010533497A5 JP2010533497A5 JP2010517160A JP2010517160A JP2010533497A5 JP 2010533497 A5 JP2010533497 A5 JP 2010533497A5 JP 2010517160 A JP2010517160 A JP 2010517160A JP 2010517160 A JP2010517160 A JP 2010517160A JP 2010533497 A5 JP2010533497 A5 JP 2010533497A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- oligonucleotide
- amplification oligonucleotide
- composition
- specific sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091034117 Oligonucleotide Proteins 0.000 claims description 62
- 230000003321 amplification Effects 0.000 claims description 59
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 59
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 18
- 239000002751 oligonucleotide probe Substances 0.000 claims description 18
- 239000013610 patient sample Substances 0.000 claims description 12
- 239000000523 sample Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims description 9
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 claims description 9
- 239000002773 nucleotide Substances 0.000 claims description 8
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95039007P | 2007-07-18 | 2007-07-18 | |
| US60/950,390 | 2007-07-18 | ||
| PCT/US2008/070334 WO2009012387A2 (en) | 2007-07-18 | 2008-07-17 | Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533497A JP2010533497A (ja) | 2010-10-28 |
| JP2010533497A5 true JP2010533497A5 (cg-RX-API-DMAC7.html) | 2011-09-08 |
| JP5622570B2 JP5622570B2 (ja) | 2014-11-12 |
Family
ID=40260376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517160A Expired - Fee Related JP5622570B2 (ja) | 2007-07-18 | 2008-07-17 | 前立腺癌においてｔｍｐｒｓｓ２／ｅｒｇ転写物変異体を検出するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100196903A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2179049A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5622570B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008275978B9 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2693973A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009012387A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11105808B2 (en) | 2004-11-12 | 2021-08-31 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| WO2011037936A2 (en) * | 2009-09-24 | 2011-03-31 | Oregon Health & Science University | Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer |
| DE202017007130U1 (de) | 2016-04-27 | 2019-08-29 | Gen-Probe Inc. | Lysereagenz für Blutzellen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541308A (en) * | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| CA2020958C (en) * | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| WO1993022461A1 (en) * | 1992-05-06 | 1993-11-11 | Gen-Probe Incorporated | Nucleic acid sequence amplification method, composition and kit |
| JP4646404B2 (ja) * | 1998-07-02 | 2011-03-09 | ジェン−プローブ・インコーポレーテッド | 分子トーチ（ｔｏｒｃｈ） |
| US20030073623A1 (en) * | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| EP1446506A4 (en) * | 2001-11-02 | 2007-07-18 | Gen Probe Inc | COMPOSITIONS, PROCESSES AND KITS FOR DETERMINING THE PRESENCE OF MYCOPLASMA PNEUMONIAE AND / OR MYCOPLASMA GENITALIUM IN A TEST TEST |
| US20070059690A1 (en) * | 2002-05-31 | 2007-03-15 | Amirul Islam | "Met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands" |
| EP1513958B1 (en) * | 2002-06-14 | 2011-08-10 | Gen-Probe Incorporated | Compositions for detecting hepatitis b virus |
| CA2501946C (en) * | 2002-10-16 | 2014-12-23 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| CA2992180C (en) * | 2004-05-07 | 2021-02-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer |
| CA2577122C (en) * | 2004-08-27 | 2017-06-13 | Gen-Probe Incorporated | Single-primer nucleic acid amplification methods |
| CA2814598A1 (en) * | 2005-09-12 | 2007-03-22 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US20100087330A1 (en) * | 2007-01-26 | 2010-04-08 | Brian Leyland-Jones | Breast cancer gene array |
-
2008
- 2008-07-17 WO PCT/US2008/070334 patent/WO2009012387A2/en not_active Ceased
- 2008-07-17 JP JP2010517160A patent/JP5622570B2/ja not_active Expired - Fee Related
- 2008-07-17 AU AU2008275978A patent/AU2008275978B9/en not_active Expired - Fee Related
- 2008-07-17 CA CA2693973A patent/CA2693973A1/en not_active Abandoned
- 2008-07-17 EP EP08796239A patent/EP2179049A4/en not_active Withdrawn
-
2010
- 2010-01-18 US US12/689,178 patent/US20100196903A1/en not_active Abandoned