JP2010533478A5 - - Google Patents
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- Publication number
- JP2010533478A5 JP2010533478A5 JP2010516305A JP2010516305A JP2010533478A5 JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5 JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5
- Authority
- JP
- Japan
- Prior art keywords
- gamma secretase
- seq
- ledaefrhds
- lvml
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 51
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 51
- 239000000758 substrate Substances 0.000 claims 37
- 238000000034 method Methods 0.000 claims 30
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 238000003776 cleavage reaction Methods 0.000 claims 8
- 230000007017 scission Effects 0.000 claims 8
- 229910052698 phosphorus Inorganic materials 0.000 claims 6
- 229910052700 potassium Inorganic materials 0.000 claims 6
- 231100000673 dose–response relationship Toxicity 0.000 claims 5
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 claims 4
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 102000003425 Tyrosinase Human genes 0.000 claims 4
- 108060008724 Tyrosinase Proteins 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
- 101800001415 Bri23 peptide Proteins 0.000 claims 2
- 102400000107 C-terminal peptide Human genes 0.000 claims 2
- 101800000655 C-terminal peptide Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 102220349549 c.73G>A Human genes 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 102200097281 rs35807406 Human genes 0.000 claims 2
- 102200153449 rs587777876 Human genes 0.000 claims 2
- 229910052722 tritium Inorganic materials 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94973807P | 2007-07-13 | 2007-07-13 | |
| US12/172,978 US20090023158A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase |
| PCT/US2008/070012 WO2009012237A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533478A JP2010533478A (ja) | 2010-10-28 |
| JP2010533478A5 true JP2010533478A5 (enrdf_load_stackoverflow) | 2011-09-01 |
Family
ID=39739883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516305A Withdrawn JP2010533478A (ja) | 2007-07-13 | 2008-07-14 | ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090023158A1 (enrdf_load_stackoverflow) |
| EP (1) | EP2183598A1 (enrdf_load_stackoverflow) |
| JP (1) | JP2010533478A (enrdf_load_stackoverflow) |
| CA (1) | CA2692604A1 (enrdf_load_stackoverflow) |
| WO (1) | WO2009012237A1 (enrdf_load_stackoverflow) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5511377B2 (ja) * | 2007-06-08 | 2014-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ４を利用したスクリーニング方法 |
| WO2009011426A1 (ja) * | 2007-07-19 | 2009-01-22 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質c-Metを利用したスクリーニング方法 |
| EP2192181A4 (en) * | 2007-08-01 | 2010-12-08 | Eisai R&D Man Co Ltd | SCREENING METHOD USING THE NEW C-RET SUBSTRATE FOR GAMMA-SECRETASE |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| JP5580598B2 (ja) * | 2007-11-15 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ７を利用したスクリーニング方法 |
| JP5508857B2 (ja) * | 2007-11-30 | 2014-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規活性を有するＥｐｈＡ４ポリペプチドおよびその用途 |
| DK2653552T3 (en) | 2010-12-17 | 2017-01-16 | Eisai R&D Man Co Ltd | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 DIVISION REACTION AS INDICATOR |
| WO2012147798A1 (ja) | 2011-04-25 | 2012-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | EphA4細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法 |
| DK2864496T4 (da) | 2012-06-22 | 2021-01-04 | Gentium S R L | Euglobulin-baseret fremgangsmåde til bestemmelse af den biologiske aktivitet af defibrotid |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| US11732260B2 (en) * | 2018-03-02 | 2023-08-22 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-β precursor protein |
| PE20220570A1 (es) | 2019-07-01 | 2022-04-20 | Eisai Randd Man Co Ltd | Anticuerpo anti-epha4 humano |
| US11913964B2 (en) | 2020-02-27 | 2024-02-27 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| WO2021206910A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| CA3189922A1 (en) | 2020-07-28 | 2022-02-03 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5441870A (en) | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5605811A (en) | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| PT730643E (pt) * | 1993-10-27 | 2001-06-29 | Lilly Co Eli | Animais transgenicos portadores do alelo de app com mutacao sueca |
| DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| WO2007058987A1 (en) * | 2005-11-10 | 2007-05-24 | Bristol-Myers Squibb Company | Methods of identifying compounds that inhibit notch cleavage |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
-
2008
- 2008-07-14 WO PCT/US2008/070012 patent/WO2009012237A1/en active Application Filing
- 2008-07-14 CA CA 2692604 patent/CA2692604A1/en not_active Abandoned
- 2008-07-14 EP EP08826401A patent/EP2183598A1/en not_active Withdrawn
- 2008-07-14 JP JP2010516305A patent/JP2010533478A/ja not_active Withdrawn
- 2008-07-14 US US12/172,978 patent/US20090023158A1/en not_active Abandoned
-
2011
- 2011-03-08 US US13/043,278 patent/US20110306071A1/en not_active Abandoned
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