JP2010531992A5 - - Google Patents
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- Publication number
- JP2010531992A5 JP2010531992A5 JP2010514187A JP2010514187A JP2010531992A5 JP 2010531992 A5 JP2010531992 A5 JP 2010531992A5 JP 2010514187 A JP2010514187 A JP 2010514187A JP 2010514187 A JP2010514187 A JP 2010514187A JP 2010531992 A5 JP2010531992 A5 JP 2010531992A5
- Authority
- JP
- Japan
- Prior art keywords
- mer
- disease
- peptide
- amyloid
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 17
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 17
- 201000010099 disease Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 238000000034 method Methods 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 9
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 201000010374 Down Syndrome Diseases 0.000 claims 6
- 206010044688 Trisomy 21 Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000001049 Amyloid Human genes 0.000 claims 1
- 108010094108 Amyloid Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290812A EP2009445A1 (en) | 2007-06-29 | 2007-06-29 | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
| PCT/IB2008/002671 WO2009004494A2 (en) | 2007-06-29 | 2008-06-26 | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531992A JP2010531992A (ja) | 2010-09-30 |
| JP2010531992A5 true JP2010531992A5 (OSRAM) | 2011-08-04 |
Family
ID=38521104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514187A Withdrawn JP2010531992A (ja) | 2007-06-29 | 2008-06-26 | アミロイドβペプチドのオリゴマー形態を検出するためのラクダ科動物の単一ドメイン抗体の使用及びその適用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100266576A1 (OSRAM) |
| EP (2) | EP2009445A1 (OSRAM) |
| JP (1) | JP2010531992A (OSRAM) |
| CA (1) | CA2691699A1 (OSRAM) |
| WO (1) | WO2009004494A2 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| EP2008666A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
| EP2143735A1 (en) * | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| EP2273273A1 (en) | 2009-07-11 | 2011-01-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | Inhibitors of the nitration of amyloid ß peptides and their uses in the diagnosis and treatment of alzheimer's disease |
| UY33253A (es) * | 2010-03-03 | 2011-09-30 | Boehringer Ingelheim Int | Polipéptidos de unión a a-beta |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| WO2012058308A2 (en) | 2010-10-26 | 2012-05-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Antibody based reagent that specifically recognizes toxic oligomeric form of beta-amyloid |
| CN103443277B (zh) | 2011-02-18 | 2016-02-24 | 国立大学法人东京农工大学 | 淀粉样蛋白低聚物结合核酸适体 |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| CA2862999A1 (en) | 2012-01-11 | 2013-07-18 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Bispecific antibody fragments for neurological disease proteins and methods of use |
| EP2873679A1 (en) * | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof |
| EP2873680A1 (en) | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Oligopeptide and methods for producing conjugates thereof |
| KR101977410B1 (ko) * | 2018-08-22 | 2019-05-10 | 주식회사 피플바이오 | 당뇨병에 대한 신규 바이오마커 및 그의 용도 |
| JP2020041861A (ja) * | 2018-09-07 | 2020-03-19 | 国立大学法人東京農工大学 | アミロイド線維を形成可能なタンパク質の脂質二重膜上における存在状態を判定する判定方法及びこれを用いた判定装置、スクリーニング方法、アミロイド線維を形成可能なタンパク質のオリゴマーの合成方法並びに人工βシートタンパク質 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
| FR2846667B1 (fr) * | 2002-11-06 | 2004-12-31 | Pasteur Institut | Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives |
| JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| JP5113523B2 (ja) * | 2004-10-13 | 2013-01-09 | アブリンクス ナームローゼ フェンノートシャップ | アミロイド−βに対するナノ抗体及びアルツハイマー病のような神経変性疾患の治療のためのナノ抗体ＴＭを含むポリペプチド |
| NZ554725A (en) * | 2004-10-25 | 2009-10-30 | Merck & Co Inc | Anti-ADDL antibodies and uses thereof |
-
2007
- 2007-06-29 EP EP07290812A patent/EP2009445A1/en not_active Withdrawn
-
2008
- 2008-06-26 EP EP08826009A patent/EP2174142A2/en not_active Withdrawn
- 2008-06-26 US US12/667,172 patent/US20100266576A1/en not_active Abandoned
- 2008-06-26 WO PCT/IB2008/002671 patent/WO2009004494A2/en not_active Ceased
- 2008-06-26 CA CA002691699A patent/CA2691699A1/en not_active Abandoned
- 2008-06-26 JP JP2010514187A patent/JP2010531992A/ja not_active Withdrawn
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