JP2010529118A5 - - Google Patents

Download PDF

Info

Publication number
JP2010529118A5
JP2010529118A5 JP2010511147A JP2010511147A JP2010529118A5 JP 2010529118 A5 JP2010529118 A5 JP 2010529118A5 JP 2010511147 A JP2010511147 A JP 2010511147A JP 2010511147 A JP2010511147 A JP 2010511147A JP 2010529118 A5 JP2010529118 A5 JP 2010529118A5
Authority
JP
Japan
Prior art keywords
hydrate
treatment
pharmaceutically acceptable
compound
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010511147A
Other languages
English (en)
Japanese (ja)
Other versions
JP5416696B2 (ja
JP2010529118A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/SE2008/050666 external-priority patent/WO2008150233A1/en
Publication of JP2010529118A publication Critical patent/JP2010529118A/ja
Publication of JP2010529118A5 publication Critical patent/JP2010529118A5/ja
Application granted granted Critical
Publication of JP5416696B2 publication Critical patent/JP5416696B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010511147A 2007-06-07 2008-06-05 オキサジアゾール誘導体およびそれらの代謝型グルタミン酸受容体増強剤としての使用 Expired - Fee Related JP5416696B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94255307P 2007-06-07 2007-06-07
US60/942,553 2007-06-07
PCT/SE2008/050666 WO2008150233A1 (en) 2007-06-07 2008-06-05 Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators - 842

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013235538A Division JP5815644B2 (ja) 2007-06-07 2013-11-14 オキサジアゾール誘導体およびそれらの代謝型グルタミン酸受容体増強剤としての使用

Publications (3)

Publication Number Publication Date
JP2010529118A JP2010529118A (ja) 2010-08-26
JP2010529118A5 true JP2010529118A5 (show.php) 2011-07-07
JP5416696B2 JP5416696B2 (ja) 2014-02-12

Family

ID=40093925

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010511147A Expired - Fee Related JP5416696B2 (ja) 2007-06-07 2008-06-05 オキサジアゾール誘導体およびそれらの代謝型グルタミン酸受容体増強剤としての使用
JP2013235538A Expired - Fee Related JP5815644B2 (ja) 2007-06-07 2013-11-14 オキサジアゾール誘導体およびそれらの代謝型グルタミン酸受容体増強剤としての使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013235538A Expired - Fee Related JP5815644B2 (ja) 2007-06-07 2013-11-14 オキサジアゾール誘導体およびそれらの代謝型グルタミン酸受容体増強剤としての使用

Country Status (33)

Country Link
US (2) US8377940B2 (show.php)
EP (2) EP2167502B3 (show.php)
JP (2) JP5416696B2 (show.php)
KR (2) KR20150116907A (show.php)
CN (2) CN102977086B (show.php)
AR (1) AR066882A1 (show.php)
AU (1) AU2008260717B2 (show.php)
BR (1) BRPI0812889A2 (show.php)
CA (1) CA2690856C (show.php)
CL (1) CL2008001667A1 (show.php)
CO (1) CO6251287A2 (show.php)
CY (2) CY1113422T1 (show.php)
DK (2) DK2167502T3 (show.php)
EC (1) ECSP109856A (show.php)
ES (2) ES2531443T3 (show.php)
HR (2) HRP20120909T4 (show.php)
IL (1) IL202158A (show.php)
ME (1) ME01488B (show.php)
MX (1) MX2009013078A (show.php)
MY (1) MY158066A (show.php)
NZ (1) NZ582445A (show.php)
PE (1) PE20090328A1 (show.php)
PL (2) PL2167502T6 (show.php)
PT (2) PT2167502E (show.php)
RS (2) RS53845B1 (show.php)
RU (2) RU2470931C2 (show.php)
SA (1) SA08290344B1 (show.php)
SI (2) SI2444399T1 (show.php)
TW (1) TWI417100B (show.php)
UA (1) UA99129C2 (show.php)
UY (1) UY31124A1 (show.php)
WO (1) WO2008150233A1 (show.php)
ZA (1) ZA200908285B (show.php)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7868008B2 (en) * 2005-08-12 2011-01-11 Astrazeneca Ab Substituted isoindolones and their use as metabotropic glutamate receptor potentiators
US7807706B2 (en) * 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200911255A (en) 2007-06-07 2009-03-16 Astrazeneca Ab Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841
TWI417100B (zh) 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
TWI445532B (zh) 2007-09-14 2014-07-21 Janssen Pharmaceuticals Inc １’，３’－二取代－４－苯基－３，４，５，６－四氫－２ｈ，１’ｈ－〔１，４’〕聯吡啶基－２’－酮化物
AU2008297877C1 (en) 2007-09-14 2013-11-07 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
CN101848893B (zh) 2007-09-14 2012-06-06 奥梅-杨森制药有限公司 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮
CA2704436C (en) * 2007-11-14 2016-01-05 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US7790760B2 (en) * 2008-06-06 2010-09-07 Astrazeneca Ab Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
WO2009154563A1 (en) 2008-06-20 2009-12-23 Astrazeneca Ab Dibenzothiazepine derivatives and use thereof
ES2439291T3 (es) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
CN102186477B (zh) 2008-10-16 2013-07-17 奥梅-杨森制药有限公司 作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物
CA2744138C (en) 2008-11-28 2015-08-11 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SI2430022T1 (sl) 2009-05-12 2014-04-30 Janssen Pharmaceuticals, Inc. 1,2,3-triazolo(4,3-a)piridin derivati in njihova uporaba za zdravljenje ali prepreäśevanje nevroloĺ kih in psihiatriäśnih nepravilnosti
US20130203995A1 (en) * 2010-01-07 2013-08-08 Astrazeneca Ab Process for Making a Metabotropic Glutamate Receptor Positive Allosteric Modulator - 874
SG184449A1 (en) * 2010-04-30 2012-11-29 Astrazeneca Ab Polymorphs of a metabotropic glutamate receptor positive allosteric modulator
WO2012062751A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN102180872B (zh) * 2011-04-01 2014-04-02 华中科技大学 [1,3,4]噁二唑类衍生物及其应用
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220051273A (ko) 2014-01-21 2022-04-26 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
IL279202B2 (en) 2014-01-21 2023-09-01 Janssen Pharmaceutica Nv Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
US10357484B2 (en) * 2015-07-17 2019-07-23 Takeda Pharmaceutical Company Limited Heterocyclic compound
AU2016297362B2 (en) 2015-07-17 2020-04-16 Takeda Pharmaceutical Company Limited Oxadiazole derivatives useful as HDAC inhibitors
EP3342772A4 (en) 2015-08-25 2019-03-27 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
WO2020102216A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Substituted heterocyclic derivatives as pi3k inhibitors
US11078204B2 (en) 2018-11-13 2021-08-03 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
EP3999035B1 (en) * 2019-07-18 2024-09-04 Abaxys Therapeutics Solid formulation of a 1,2,4-oxadiazole derivative
GB2621323A (en) 2022-08-03 2024-02-14 Sirgartan Holdings Ltd Treatments for obsessive compulsive disorder

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2008803A (en) * 1932-04-18 1935-07-23 Stephan Engineering Corp Fuel atomizing and igniting means
US3993617A (en) * 1975-10-30 1976-11-23 Morton-Norwich Products, Inc. Antifungal 2-substituted phthalimidines
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
WO1992017448A1 (fr) 1991-04-01 1992-10-15 Kyowa Hakko Kogyo Co., Ltd. Derive de 3-methylenisoindolin-1-one
TW219935B (show.php) 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
EP0602814A1 (en) 1992-12-18 1994-06-22 Takeda Chemical Industries, Ltd. Crystal forms of optically active isoindolines and their use
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
CA2245586A1 (en) * 1996-02-06 1997-08-14 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
AU7548298A (en) 1997-05-30 1998-12-30 Meiji Seika Kaisha Ltd. Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same
EP1037878A2 (en) 1997-11-21 2000-09-27 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists for treating central nervous system diseases
NZ521576A (en) * 2000-02-29 2005-06-24 Mitsubishi Pharma Corp Novel cyclic amide derivatives
WO2002010146A1 (en) 2000-07-31 2002-02-07 Smithkline Beecham P.L.C. Carboxamide compounds and their use as antagonists of a human 11cby receptor
IL158491A0 (en) * 2001-04-19 2004-05-12 Eisai Co Ltd 2-iminopyrrolidine derivatives
NZ531153A (en) 2001-08-09 2005-10-28 Ono Pharmaceutical Co Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
WO2003087044A2 (en) 2002-04-09 2003-10-23 7Tm Pharma A/S Novel carboxamide compounds for use in mch receptor related disorders
FR2840302B1 (fr) 2002-06-03 2004-07-16 Aventis Pharma Sa Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
DE10238865A1 (de) 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB0223232D0 (en) 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
PL376890A1 (pl) * 2002-11-26 2006-01-09 Maruishi Pharmaceutical Co., Ltd. Pochodne izoindoliny
WO2004087048A2 (en) 2003-03-26 2004-10-14 Merck & Co. Inc. Benzamide modulators of metabotropic glutamate receptors
GB0308025D0 (en) 2003-04-07 2003-05-14 Glaxo Group Ltd Compounds
US7129260B2 (en) * 2003-06-02 2006-10-31 Abbott Laboratories Isoindolinone kinase inhibitors
EP1723126A2 (en) 2003-10-22 2006-11-22 Eli Lilly And Company Novel mch receptor antagonists
WO2005074643A2 (en) 2004-01-30 2005-08-18 Smithkline Beecham Corporation Benzamide compounds useful as rock inhibitors
DE602005008558D1 (de) 2004-02-18 2008-09-11 Astrazeneca Ab Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen reznkungen
JPWO2005085214A1 (ja) 2004-03-05 2008-01-17 萬有製薬株式会社 ジアリール置換複素５員環誘導体
CN102558082B (zh) 2004-03-05 2015-09-30 日产化学工业株式会社 异噁唑啉取代苯甲酰胺化合物的制备中间体
SE0400970D0 (sv) 2004-04-14 2004-04-14 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
CN101048157A (zh) 2004-10-25 2007-10-03 默克公司 代谢型谷氨酸受体的杂环二氢茚酮增强剂
AU2006216917A1 (en) 2005-02-24 2006-08-31 Merck Sharp & Dohme Corp. Benzazole potentiators of metabotropic glutamate receptors
EP1893606A2 (en) * 2005-05-18 2008-03-05 Addex Pharma SA Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510142D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
TW200728277A (en) 2005-06-29 2007-08-01 Palau Pharma Sa Bicyclic derivatives as P38 inhibitors
EP1912939A1 (en) * 2005-08-12 2008-04-23 AstraZeneca AB Metabotropic glutamate-receptor-potentiating isoindolones
US7868008B2 (en) * 2005-08-12 2011-01-11 Astrazeneca Ab Substituted isoindolones and their use as metabotropic glutamate receptor potentiators
US7807706B2 (en) * 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
JP5048675B2 (ja) * 2005-09-27 2012-10-17 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのオキサジアゾリルピラゾロ−ピリミジン類
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
TW200911255A (en) * 2007-06-07 2009-03-16 Astrazeneca Ab Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841
TWI417100B (zh) * 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途

Similar Documents

Publication Publication Date Title
JP2010529118A5 (show.php)
JP2012532874A5 (show.php)
JP2010536849A5 (show.php)
JP2011524850A5 (show.php)
JP2012255026A5 (show.php)
JP2015524444A5 (show.php)
JP2010528011A5 (show.php)
JP2012507538A5 (show.php)
BRPI1011220A2 (pt) composição farmacêutica, métodos para tratar uma doença ou distúrbio, para administração respiratória de dois ou mais agentes ativos, para administração respiratória de uma combinação de agentes ativos, e, para preparar uma composição adequada.
CY2017014I1 (el) Φαρμακευτικοι συνδυασμοι που περιεχουν βενζοξαζινες για τη θεραπεια νοσων των αναπνευστικων οδων
JP2014530220A5 (show.php)
CL2007001131A1 (es) Compuestos derivados de purina sustituida; proceso de preparacion; composicion farmaceutica; y uso en el tratamiento de una enfermedad inflamatoria u obstructiva de las vias respiratorias.
HRP20120144T1 (en) Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity
DK2276485T3 (da) Anvendelse af epothilon d i behandling af tau-associerede sygdomme,herunder alzheimers sygdom
JP2009500443A5 (show.php)
JP2015524472A5 (show.php)
JP2012515184A5 (show.php)
BRPI0807285A2 (pt) "composição, método para preparar composição farmacêutica, forma unitária de dosagem, método para admnistrar um agente biologicamente ativo a um animal necessitando o agente, método para aumentar a biodisponibilidade de um agente biologicamente ativo, método para preparar uma composição e composto"
JP2007516193A5 (show.php)
JP2013541583A5 (show.php)
JP2012504560A5 (show.php)
JP2008513510A5 (show.php)
JP2009062388A5 (show.php)
JP2015516419A5 (show.php)
JP2010500284A5 (show.php)