JP2010529040A - イオン性樹脂系の懸濁液における薬物放出の調節 - Google Patents

イオン性樹脂系の懸濁液における薬物放出の調節 Download PDF

Info

Publication number
JP2010529040A
JP2010529040A JP2010510531A JP2010510531A JP2010529040A JP 2010529040 A JP2010529040 A JP 2010529040A JP 2010510531 A JP2010510531 A JP 2010510531A JP 2010510531 A JP2010510531 A JP 2010510531A JP 2010529040 A JP2010529040 A JP 2010529040A
Authority
JP
Japan
Prior art keywords
ionic
release
drug
composition
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010510531A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010529040A5 (enExample
Inventor
パサック，ヤシュワント・ヴィシュヌパント
マクマヘン，ラッセル・リー
テングラー，マーク
Original Assignee
ネオス・セラピューティクス・エルピー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ネオス・セラピューティクス・エルピー filed Critical ネオス・セラピューティクス・エルピー
Publication of JP2010529040A publication Critical patent/JP2010529040A/ja
Publication of JP2010529040A5 publication Critical patent/JP2010529040A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010510531A 2007-05-30 2008-05-30 イオン性樹脂系の懸濁液における薬物放出の調節 Pending JP2010529040A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94095607P 2007-05-30 2007-05-30
PCT/US2008/065408 WO2008151071A1 (en) 2007-05-30 2008-05-30 Modifying drug release in suspensions of ionic resin systems

Publications (2)

Publication Number Publication Date
JP2010529040A true JP2010529040A (ja) 2010-08-26
JP2010529040A5 JP2010529040A5 (enExample) 2011-07-14

Family

ID=40094143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010510531A Pending JP2010529040A (ja) 2007-05-30 2008-05-30 イオン性樹脂系の懸濁液における薬物放出の調節

Country Status (6)

Country Link
US (1) US8313770B2 (enExample)
EP (1) EP2164631A4 (enExample)
JP (1) JP2010529040A (enExample)
CA (1) CA2689101C (enExample)
MX (1) MX2009013019A (enExample)
WO (1) WO2008151071A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013545746A (ja) * 2010-11-10 2013-12-26 ルビコン リサーチ プライベート リミテッド 徐放性組成物
JP2016510019A (ja) * 2013-02-28 2016-04-04 ファイザー・インク 安定性を増強した新規な液体組成物
JP2019515045A (ja) * 2016-05-03 2019-06-06 スペクトリックス セラピューティクス， エルエルシーＳｐｅｃｔｒｉｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ 甲状腺ホルモン又はそのアナログを提供する組成物及び方法
JP2020536892A (ja) * 2017-10-09 2020-12-17 ローズ ファーマシューティカルズ エル．ピー． 医薬レジネート組成物、それを作製する方法、およびその使用

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2018160T3 (da) 2006-03-16 2012-02-06 Tris Pharma Inc Modificeret depotformuleringer indeholdende lægemiddel-ionbytterharpikskomplekser
AU2008296298B2 (en) 2007-09-06 2012-12-06 The Cola-Cola Company Systems and methods for monitoring and controlling the dispense of a plurality of product forming ingredients
RU2496711C2 (ru) 2007-09-06 2013-10-27 Дзе Кока-Кола Компани Система и способ программирования вариантов дозирования в разливочном устройстве для приготовления продуктов
US20100273822A1 (en) * 2009-04-22 2010-10-28 William Wayne Howard Immediate release compositions and methods for delivering drug formulations using strong acid ion exchange resins
BR112012013487A2 (pt) 2009-12-02 2017-10-03 Adamas Pharmaceuticals Inc Composições de amantadina e métodos de uso
US8470375B1 (en) 2010-01-05 2013-06-25 Neos Therapeutics, Lp Method of formulating and designing liquid drug suspensions containing ion exchange resin particles
US9339478B2 (en) * 2011-02-04 2016-05-17 Reckitt Benckiser Llc Pharmaceutical formulation
US8287903B2 (en) * 2011-02-15 2012-10-16 Tris Pharma Inc Orally effective methylphenidate extended release powder and aqueous suspension product
EP2508174A1 (en) * 2011-04-06 2012-10-10 Ljiljana Sovic Brkicic Pharmaceutical composition
US20130004586A1 (en) * 2011-06-24 2013-01-03 Vachon David J Biologically Efficacious Compositions, Articles of Manufacture and Processes for Producing and/or Using Same
EP2726066B1 (en) 2011-06-28 2021-03-31 Neos Therapeutics, LP Dosage forms of amphetamine for oral administration
CA2880456A1 (en) 2012-08-15 2014-02-20 Tris Pharma, Inc. Methylphenidate extended release chewable tablet
US20140122120A1 (en) * 2012-10-30 2014-05-01 Pacesetter, Inc. Systems and methods for providing photo-based patient verification for use with implantable medical device programmers
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
WO2016001937A2 (en) * 2014-06-30 2016-01-07 Rubicon Research Private Limited Modified release pharmaceutical preparations
AU2015324986A1 (en) * 2014-10-01 2017-04-20 Crop Enhancement, Inc. Agrochemical resinates for agricultural applications
US11590228B1 (en) 2015-09-08 2023-02-28 Tris Pharma, Inc Extended release amphetamine compositions
MX2020002078A (es) 2017-08-24 2020-09-21 Adamas Pharma Llc Composiciones de amantadina, preparaciones de estas y métodos de uso.
US11590081B1 (en) 2017-09-24 2023-02-28 Tris Pharma, Inc Extended release amphetamine tablets
US12458592B1 (en) 2017-09-24 2025-11-04 Tris Pharma, Inc. Extended release amphetamine tablets
WO2019094292A1 (en) * 2017-11-09 2019-05-16 Spectrix Therapeutics, LLC Compositions and methods of providing thyroid hormone of analogs thereof
AU2018388577B2 (en) 2017-12-18 2024-06-06 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release
WO2019126214A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release
CA3085941A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6067418A (ja) * 1983-09-16 1985-04-17 ファイゾンス・コーポレイション イオン性薬剤を含有する液状の長期放出型製薬組成物
JPH05504574A (ja) * 1990-03-12 1993-07-15 ビーチャム　グループ　ピーエルシー 組成物
JPH05279246A (ja) * 1992-04-02 1993-10-26 Rohto Pharmaceut Co Ltd 水性懸濁製剤
JP2003012562A (ja) * 2001-04-09 2003-01-15 Rohm & Haas Co 活性成分の制御型溶解
JP2006512327A (ja) * 2002-11-26 2006-04-13 ホ−レンベック ギャリ− ア−ル 高度に水溶性の電解質薬剤のための水性徐放性ドラッグデリバリーシステム
WO2007001300A1 (en) * 2005-06-28 2007-01-04 Ucb, S.A. Multiple active drug-resin conjugate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK79841C (da) * 1952-08-04 1955-09-12 Behringwerke Ag Fremgangsmåde til fremstilling af stabile γ-globulinpræparater.
US3173876A (en) * 1960-05-27 1965-03-16 John C Zobrist Cleaning methods and compositions
US3276586A (en) * 1963-08-30 1966-10-04 Rosaen Filter Co Indicating means for fluid filters
US3546142A (en) * 1967-01-19 1970-12-08 Amicon Corp Polyelectrolyte structures
US3541006A (en) * 1968-07-03 1970-11-17 Amicon Corp Ultrafiltration process
US3541005A (en) * 1969-02-05 1970-11-17 Amicon Corp Continuous ultrafiltration of macromolecular solutions
US4285987A (en) * 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4221778A (en) * 1979-01-08 1980-09-09 Pennwalt Corporation Prolonged release pharmaceutical preparations
US4762709A (en) * 1983-09-16 1988-08-09 Pennwalt Corporation Liquid prolonged release pharmaceutical formulations containing ionic constituents
US4692462A (en) * 1985-03-18 1987-09-08 Menley & James Laboratories, Ltd. Compositions and method of controlling transdermal penetration of topical and systemic agents
US4999189A (en) * 1988-11-14 1991-03-12 Schering Corporation Sustained release oral suspensions
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
US6613358B2 (en) * 1998-03-18 2003-09-02 Theodore W. Randolph Sustained-release composition including amorphous polymer
US7815937B2 (en) * 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
US20050232987A1 (en) * 2004-03-12 2005-10-20 Viswanathan Srinivasan Dosage form containing a morphine derivative and another drug
US20070092553A1 (en) * 2005-10-21 2007-04-26 Pfab Lp Compositions and methods of making rapidly dissolving lonically masked formulations

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6067418A (ja) * 1983-09-16 1985-04-17 ファイゾンス・コーポレイション イオン性薬剤を含有する液状の長期放出型製薬組成物
JPH05504574A (ja) * 1990-03-12 1993-07-15 ビーチャム　グループ　ピーエルシー 組成物
JPH05279246A (ja) * 1992-04-02 1993-10-26 Rohto Pharmaceut Co Ltd 水性懸濁製剤
JP2003012562A (ja) * 2001-04-09 2003-01-15 Rohm & Haas Co 活性成分の制御型溶解
JP2006512327A (ja) * 2002-11-26 2006-04-13 ホ−レンベック ギャリ− ア−ル 高度に水溶性の電解質薬剤のための水性徐放性ドラッグデリバリーシステム
WO2007001300A1 (en) * 2005-06-28 2007-01-04 Ucb, S.A. Multiple active drug-resin conjugate

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013545746A (ja) * 2010-11-10 2013-12-26 ルビコン リサーチ プライベート リミテッド 徐放性組成物
JP2016510019A (ja) * 2013-02-28 2016-04-04 ファイザー・インク 安定性を増強した新規な液体組成物
JP2017078084A (ja) * 2013-02-28 2017-04-27 ファイザー・インク 安定性を増強した新規な液体組成物
JP2019515045A (ja) * 2016-05-03 2019-06-06 スペクトリックス セラピューティクス， エルエルシーＳｐｅｃｔｒｉｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ 甲状腺ホルモン又はそのアナログを提供する組成物及び方法
JP2021073275A (ja) * 2016-05-03 2021-05-13 スペクトリックス セラピューティクス， エルエルシーＳｐｅｃｔｒｉｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ 甲状腺ホルモン又はそのアナログを提供する組成物及び方法
JP2020536892A (ja) * 2017-10-09 2020-12-17 ローズ ファーマシューティカルズ エル．ピー． 医薬レジネート組成物、それを作製する方法、およびその使用
US11690840B2 (en) 2017-10-09 2023-07-04 Rhodes Pharmaceuticals L.P. Pharmaceutical resinate compositions and methods of making and using thereof

Also Published As

Publication number Publication date
US8313770B2 (en) 2012-11-20
US20090011027A1 (en) 2009-01-08
MX2009013019A (es) 2010-04-01
CA2689101A1 (en) 2008-12-11
WO2008151071A1 (en) 2008-12-11
EP2164631A4 (en) 2013-08-21
CA2689101C (en) 2013-01-22
EP2164631A1 (en) 2010-03-24

Similar Documents

Publication Publication Date Title
US8313770B2 (en) Modifying drug release in suspensions of ionic resin systems
US9522120B2 (en) Compositions and methods of making sustained release liquid formulations
US8840924B2 (en) Compositions and methods of making rapidly dissolving ionically masked formulations
US20100112054A1 (en) Tablets and discs with compartments with two or more drugs for release at certain intervals and with specific rates
US20090317465A1 (en) Composition and method of preparation of release systems for constant (zero-order) release of active agents
WO2011110939A2 (en) Pharmaceutical compositions of substituted benzhydrylpiperazines
CN101495150B (zh) 药理活性物质的吸收性被改善的药物组合物
WO2018055641A1 (en) Oral modified release formulations
KR102055859B1 (ko) 아캄프로세이트 제제, 그것의 사용 방법, 및 그것을 포함하는 조합
WO2008157228A1 (en) New methods for taste-masking
US20040241135A1 (en) Therapeutic compositions including bio-availability enhancers
WO2006117803A2 (en) Transmucosal drug delivery systems
JP2014074019A (ja) 抗ロタウイルス剤
Shivaraj Novel Sustained Release of Bioadhesive Gastro Retentive Drug Delivery System Containing Flouroquinolones
CN101180039A (zh) 至少一种形式的文拉法辛的缓释组合物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110526

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110526

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110526

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130311

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130314

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130805