JP2010528620A - 骨髄異形成症候群(mds)に関連する増殖性障害の治療および診断のためのsall4の標的化方法 - Google Patents
骨髄異形成症候群(mds)に関連する増殖性障害の治療および診断のためのsall4の標的化方法 Download PDFInfo
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- JP2010528620A JP2010528620A JP2010510523A JP2010510523A JP2010528620A JP 2010528620 A JP2010528620 A JP 2010528620A JP 2010510523 A JP2010510523 A JP 2010510523A JP 2010510523 A JP2010510523 A JP 2010510523A JP 2010528620 A JP2010528620 A JP 2010528620A
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G01N33/57505—
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- G01N33/5759—
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
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- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/809,871 US20080241110A1 (en) | 2005-11-29 | 2007-06-01 | Targeting of sall4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (MDS) |
| PCT/US2008/065349 WO2008151035A2 (en) | 2007-06-01 | 2008-05-30 | Targeting of sall4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (mds) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010528620A true JP2010528620A (ja) | 2010-08-26 |
| JP2010528620A5 JP2010528620A5 (enExample) | 2011-07-14 |
Family
ID=40094374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510523A Pending JP2010528620A (ja) | 2007-06-01 | 2008-05-30 | 骨髄異形成症候群(mds)に関連する増殖性障害の治療および診断のためのsall4の標的化方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080241110A1 (enExample) |
| EP (1) | EP2167684A4 (enExample) |
| JP (1) | JP2010528620A (enExample) |
| AU (1) | AU2008259976A1 (enExample) |
| CA (1) | CA2690725A1 (enExample) |
| WO (1) | WO2008151035A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017171097A1 (ja) * | 2016-04-01 | 2017-10-05 | 公益財団法人ヒューマンサイエンス振興財団 | 未分化細胞間における分化傾向の評価方法、分化傾向の評価マーカーとしてのSALL3 mRNA、及び、未分化細胞の分化能力の制御方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010042800A1 (en) * | 2008-10-10 | 2010-04-15 | Nevada Cancer Institute | Methods of reprogramming somatic cells and methods of use for such cells |
| CN103124784A (zh) | 2010-08-23 | 2013-05-29 | 纽约州立大学研究基金会 | 用于扩增干细胞的方法和这些细胞的用途 |
| SG11201400499PA (en) | 2011-09-20 | 2014-06-27 | Brigham & Womens Hospital | Sall4 and uses thereof |
| US20140273016A1 (en) * | 2013-03-14 | 2014-09-18 | William Michael Schopperle | Device and method for the detection and diagnosis of aggressive and metastatic cancer and cancer stem cells employing podocalyxin and tra biomarkers |
| WO2019140088A1 (en) * | 2018-01-12 | 2019-07-18 | Celgene Corporation | Methods for screening cereblon modifying compounds |
| CN110592211A (zh) * | 2019-08-15 | 2019-12-20 | 南开大学 | 基因foxd4在制备急性髓系白血病诊断试剂盒的应用及试剂盒 |
| CN111713450B (zh) * | 2020-05-26 | 2022-07-12 | 上海交通大学医学院 | 一种慢性粒细胞白血病的pdx模型的建立方法 |
| CN113142130B (zh) * | 2021-03-12 | 2022-11-04 | 山东融发生物科技开发有限公司 | 一种抗病猪的选育方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020081592A1 (en) * | 2000-03-07 | 2002-06-27 | Whitehead Institute For Biomedical Research | Reproduction-specific genes |
| US20070015271A1 (en) * | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
| ES2309485T3 (es) * | 2003-01-06 | 2008-12-16 | Wyeth | Composiciones y procedimientos para diagnosticar y tratar los canceres de colon. |
| US20050181381A1 (en) * | 2003-04-18 | 2005-08-18 | University Of Massachusetts | Prognosis, diagnosis and treatment of bone marrow derived stem cell associated cancer |
| EP2273271A3 (en) * | 2004-04-23 | 2011-04-13 | Rigshospitalet, Copenhagen University Hospital | Use of novel biomarkers for detection of testicular carcinoma in situ and derived cancers in human samples |
| US7790407B2 (en) * | 2005-11-29 | 2010-09-07 | Nevada Cancer Institute | Targeting of SALL4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (MDS) |
-
2007
- 2007-06-01 US US11/809,871 patent/US20080241110A1/en not_active Abandoned
-
2008
- 2008-05-30 JP JP2010510523A patent/JP2010528620A/ja active Pending
- 2008-05-30 WO PCT/US2008/065349 patent/WO2008151035A2/en not_active Ceased
- 2008-05-30 EP EP08756538A patent/EP2167684A4/en not_active Withdrawn
- 2008-05-30 AU AU2008259976A patent/AU2008259976A1/en not_active Abandoned
- 2008-05-30 CA CA2690725A patent/CA2690725A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017171097A1 (ja) * | 2016-04-01 | 2017-10-05 | 公益財団法人ヒューマンサイエンス振興財団 | 未分化細胞間における分化傾向の評価方法、分化傾向の評価マーカーとしてのSALL3 mRNA、及び、未分化細胞の分化能力の制御方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008259976A1 (en) | 2008-12-11 |
| EP2167684A4 (en) | 2010-12-29 |
| EP2167684A2 (en) | 2010-03-31 |
| US20080241110A1 (en) | 2008-10-02 |
| WO2008151035A2 (en) | 2008-12-11 |
| WO2008151035A3 (en) | 2009-01-29 |
| CA2690725A1 (en) | 2008-12-11 |
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