JP2010527451A - 大型アレイ式示差走査熱量計のdsc測定装置 - Google Patents
大型アレイ式示差走査熱量計のdsc測定装置 Download PDFInfo
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- JP2010527451A JP2010527451A JP2010508532A JP2010508532A JP2010527451A JP 2010527451 A JP2010527451 A JP 2010527451A JP 2010508532 A JP2010508532 A JP 2010508532A JP 2010508532 A JP2010508532 A JP 2010508532A JP 2010527451 A JP2010527451 A JP 2010527451A
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- calorimeter
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K17/00—Measuring quantity of heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
- G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
- G01N25/4806—Details not adapted to a particular type of sample
- G01N25/4813—Details not adapted to a particular type of sample concerning the measuring means
- G01N25/482—Details not adapted to a particular type of sample concerning the measuring means concerning the temperature responsive elements
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
一部の実施形態では、走査ブロック110は、制御モジュール116および主要な熱量計ブロック106と直接連通することができる。一部の実施形態では、センサアレイは、96が個々にセンサ104を配置するのではなく、一体型設計とすることができる。一部の実施形態では、センサアレイは異なる形状にすることもでき、他の96ウェル式生物工学的応用で使用される明らかなハイスループットのスクリーニング構造体内に384、1536またはそれ以上センサを有することができる。一部の実施形態では、測定アセンブリは真空に配置されてもよい。一部の実施形態では、部品配置、フレーム、外装アセンブリは大きく変えられて、全体設計をより小型にすることができる。
Claims (6)
- a)1つ以上の走査制御モジュールと、
b)走査制御モジュールを熱連通した走査ブロックと、
c)1つ以上の温度制御モジュールと、
d)温度制御モジュールと熱連通した熱量計ブロックと、
e)熱量計ブロックと接続された1つ以上の熱流量センサと、
f)熱流量センサと熱連通した1つ以上のセンサピンと、
g)断熱シールドと、
h)断熱シールドと熱連通した1つ以上のシールド制御モジュールとを備える、熱量計アレイ。 - 熱量計ブロックの温度勾配が、2段の熱量計ブロックの構造体の中の不動態の低熱伝導性減衰層を使用して最小限に抑えられる、請求項1に記載の熱量計アレイ。
- 96のセンサ信号の各々が、アレイ内の任意の他のセンサからの信号またはアレイ内の複数の他の特異的に配置されたセンサの平均と組み合わされると、シングルエンドモードか差動モードかのいずれかで使用され得る、請求項1に記載の熱量計アレイ。
- 断熱シールドが、96ウェル試料プレートを受承することができる、請求項1に記載の熱量計アレイ。
- 96ウェル試料プレート内の96のウェルの各々が、120°までの温度の水を封じ込めるのに十分な圧力まで封止される、請求項1に記載の熱量計アレイ。
- 120°までの温度の蒸発または沸騰による水の減少を防ぐのに適した封止ガスケットに加えられる封止力を生成することができるリフトアセンブリをさらに備える、請求項1に記載の熱量計アレイ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93046307P | 2007-05-16 | 2007-05-16 | |
US60/930,463 | 2007-05-16 | ||
PCT/US2008/063504 WO2008144297A1 (en) | 2007-05-16 | 2008-05-13 | A large array defferential scanning calorimeter, dsc measuring unit |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010527451A true JP2010527451A (ja) | 2010-08-12 |
JP5143897B2 JP5143897B2 (ja) | 2013-02-13 |
Family
ID=40122118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010508532A Expired - Fee Related JP5143897B2 (ja) | 2007-05-16 | 2008-05-13 | 大型アレイ式示差走査熱量計のdsc測定装置 |
Country Status (4)
Country | Link |
---|---|
US (2) | US8388220B2 (ja) |
EP (1) | EP2156171A4 (ja) |
JP (1) | JP5143897B2 (ja) |
WO (1) | WO2008144297A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2156171A4 (en) * | 2007-05-16 | 2016-06-29 | Energetic Genomics Corp | MEASURING UNIT FOR DYNAMIC DIFFERENTIAL CALORIMETRY (DDK) WITH LARGE ARRANGEMENT |
JP5709160B2 (ja) * | 2010-03-29 | 2015-04-30 | 株式会社日立ハイテクサイエンス | 熱分析装置 |
WO2017122174A1 (en) | 2016-01-14 | 2017-07-20 | Monaselidze Jamlet | Differential scanning microcalorimeter device for detecting disease and monitoring therapeutic efficacy |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US4255961A (en) * | 1978-10-17 | 1981-03-17 | University Of Va. Alumni Patents Foundation | Differential calorimeter based on the heat leak principle |
WO1999060356A1 (en) * | 1998-05-20 | 1999-11-25 | Consiglio Nazionale Delle Ricerche | Heat flux control method and apparatus for calorimetry, adiabatic shielding, precise temperature setting and the like |
WO2003025528A2 (en) * | 2001-09-18 | 2003-03-27 | Energetic Geonomics Corporation | A high throughput energy array |
JP2003315292A (ja) * | 2002-04-01 | 2003-11-06 | Xerox Corp | 化学反応を検知するためのナノ熱量計 |
JP2004219271A (ja) * | 2003-01-15 | 2004-08-05 | Device Nanotech Reseach Institute:Kk | 解析用デバイス、SNPsの同定用デバイス、液体供給装置、検査デバイス、温度処理装置 |
JP2006201169A (ja) * | 2005-01-18 | 2006-08-03 | Palo Alto Research Center Inc | 蒸発熱損失を最小限にするための物理的バリアの使用 |
Family Cites Families (12)
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US3789662A (en) * | 1971-10-26 | 1974-02-05 | Instrumentation Labor Inc | Calorimetry |
US4892707A (en) * | 1983-07-25 | 1990-01-09 | American Cyanamid Company | Apparatus for the calorimetry of chemical processes |
US5439291C1 (en) * | 1992-03-02 | 2002-04-16 | Ta Instr Inc | Method and apparatus for ac differential thermal analysis |
US5806979A (en) * | 1996-11-19 | 1998-09-15 | Iowa State University Research Foundation, Inc. | Calorimetric system and method |
JP2002532717A (ja) * | 1998-12-11 | 2002-10-02 | サイミックス テクノロジーズ、インク | 迅速な物質特性評価のためのセンサ配列に基づくシステム及びその方法 |
AU4205600A (en) * | 1999-07-28 | 2001-02-19 | Microcal, Llc | Pressure perturbation calorimetry instruments and methods |
US6742926B1 (en) * | 2000-07-10 | 2004-06-01 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Methods of testing thermal insulation and associated test apparatus |
US7371006B2 (en) * | 2004-02-10 | 2008-05-13 | Perkinelmer Las, Inc. | Differential scanning calorimeter (DSC) with temperature controlled furnace |
JP4812017B2 (ja) * | 2006-07-26 | 2011-11-09 | エスアイアイ・ナノテクノロジー株式会社 | 熱分析装置及びその乾燥方法 |
EP2156171A4 (en) | 2007-05-16 | 2016-06-29 | Energetic Genomics Corp | MEASURING UNIT FOR DYNAMIC DIFFERENTIAL CALORIMETRY (DDK) WITH LARGE ARRANGEMENT |
EP2283346B1 (en) * | 2008-06-06 | 2018-11-21 | PerkinElmer Health Sciences, Inc. | Calorimeter and methods of using it and control systems therefor |
EP2571696B1 (en) * | 2010-05-21 | 2019-08-07 | Hewlett-Packard Development Company, L.P. | Fluid ejection device with circulation pump |
-
2008
- 2008-05-13 EP EP08755372.3A patent/EP2156171A4/en not_active Withdrawn
- 2008-05-13 WO PCT/US2008/063504 patent/WO2008144297A1/en active Application Filing
- 2008-05-13 JP JP2010508532A patent/JP5143897B2/ja not_active Expired - Fee Related
- 2008-05-13 US US12/598,672 patent/US8388220B2/en not_active Expired - Fee Related
-
2012
- 2012-12-18 US US13/718,364 patent/US8746967B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4255961A (en) * | 1978-10-17 | 1981-03-17 | University Of Va. Alumni Patents Foundation | Differential calorimeter based on the heat leak principle |
WO1999060356A1 (en) * | 1998-05-20 | 1999-11-25 | Consiglio Nazionale Delle Ricerche | Heat flux control method and apparatus for calorimetry, adiabatic shielding, precise temperature setting and the like |
WO2003025528A2 (en) * | 2001-09-18 | 2003-03-27 | Energetic Geonomics Corporation | A high throughput energy array |
JP2003315292A (ja) * | 2002-04-01 | 2003-11-06 | Xerox Corp | 化学反応を検知するためのナノ熱量計 |
JP2004219271A (ja) * | 2003-01-15 | 2004-08-05 | Device Nanotech Reseach Institute:Kk | 解析用デバイス、SNPsの同定用デバイス、液体供給装置、検査デバイス、温度処理装置 |
JP2006201169A (ja) * | 2005-01-18 | 2006-08-03 | Palo Alto Research Center Inc | 蒸発熱損失を最小限にするための物理的バリアの使用 |
Also Published As
Publication number | Publication date |
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US20130177039A1 (en) | 2013-07-11 |
WO2008144297A1 (en) | 2008-11-27 |
JP5143897B2 (ja) | 2013-02-13 |
EP2156171A4 (en) | 2016-06-29 |
US8746967B2 (en) | 2014-06-10 |
EP2156171A1 (en) | 2010-02-24 |
US8388220B2 (en) | 2013-03-05 |
US20100322281A1 (en) | 2010-12-23 |
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