JP2010525073A - 代謝型グルタミン酸受容体7の調節による老人性難聴の治療及び/又は予防 - Google Patents

代謝型グルタミン酸受容体7の調節による老人性難聴の治療及び/又は予防 Download PDF

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JP2010525073A
JP2010525073A JP2010506460A JP2010506460A JP2010525073A JP 2010525073 A JP2010525073 A JP 2010525073A JP 2010506460 A JP2010506460 A JP 2010506460A JP 2010506460 A JP2010506460 A JP 2010506460A JP 2010525073 A JP2010525073 A JP 2010525073A
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mglur7
grm7
senile deafness
snps
modulator
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JP2010525073A5 (enExample
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リック フリードマン,
ステファン ディートリッヒ,
ガイド ヴァンカンプ,
マシュー, ジェー. フエンテルマン,
ラール, ラット ヴァン
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ハウス イアー インスティトゥート
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010506460A 2007-04-23 2008-04-23 代謝型グルタミン酸受容体7の調節による老人性難聴の治療及び/又は予防 Pending JP2010525073A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91352007P 2007-04-23 2007-04-23
US488007P 2007-11-30 2007-11-30
US2100708P 2008-01-14 2008-01-14
PCT/US2008/061330 WO2008131439A1 (en) 2007-04-23 2008-04-23 Treatment and/or prevention of presbycusis by modulation of metabotropic glutamate receptor 7

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JP2010525073A true JP2010525073A (ja) 2010-07-22
JP2010525073A5 JP2010525073A5 (enExample) 2011-06-02

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JP2010506460A Pending JP2010525073A (ja) 2007-04-23 2008-04-23 代謝型グルタミン酸受容体7の調節による老人性難聴の治療及び/又は予防

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US (1) US20100197800A1 (enExample)
EP (1) EP2150244A1 (enExample)
JP (1) JP2010525073A (enExample)
WO (1) WO2008131439A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020535208A (ja) * 2017-09-26 2020-12-03 プラグマ セラピューティクス 新規な複素環式化合物
KR20240114499A (ko) 2023-01-17 2024-07-24 고려대학교 산학협력단 글루타민을 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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US9132087B2 (en) 2008-04-21 2015-09-15 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
MY161021A (en) 2008-05-14 2017-03-31 Otonomy Inc Controlled release corticosteroid and methods for the treatment of otic disorders
US8846770B2 (en) 2008-06-18 2014-09-30 Otonomy, Inc. Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
WO2010011466A2 (en) 2008-06-27 2010-01-28 Otonomy, Inc. Controlled-release cns modulating compositions and methods for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
WO2010048095A2 (en) 2008-10-22 2010-04-29 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
US9486405B2 (en) 2013-08-27 2016-11-08 Otonomy, Inc. Methods for the treatment of pediatric otic disorders
WO2015120453A1 (en) 2014-02-10 2015-08-13 University Of South Florida Hormone treatment for age-related hearing loss-presbycusis
GB202106871D0 (en) 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds
GB202106872D0 (en) 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds
GB202216962D0 (en) 2022-11-14 2022-12-28 Addex Pharmaceuticals Sa Novel compounds
GB202216963D0 (en) 2022-11-14 2022-12-28 Addex Pharmaceuticals Sa Novel compounds
GB202216960D0 (en) 2022-11-14 2022-12-28 Addex Pharmaceuticals Sa Novel compounds

Citations (4)

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WO2006071730A1 (en) * 2004-12-27 2006-07-06 Astrazeneca Ab Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders
WO2007018998A2 (en) * 2005-08-05 2007-02-15 Astrazeneca Ab Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
WO2007021309A1 (en) * 2005-08-12 2007-02-22 Astrazeneca Ab Substituted isoindolones and their use as metabotropic glutamate receptor potentiators
WO2007025709A2 (en) * 2005-08-31 2007-03-08 Novartis Ag Organic compounds

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EP1255735A2 (en) * 2000-02-03 2002-11-13 Eli Lilly And Company Pyridine derivatives as potentiators of glutamate receptors
US7507836B2 (en) * 2003-03-26 2009-03-24 Merck & Co. Inc. Benzamide modulators of metabotropic glutamate receptors
MX2007003922A (es) * 2004-10-05 2007-06-07 Merz Pharma Gmbh & Co Kgaa Nuevas propenonas ciclicas y aciclicas para tratar trastornos del sistema nervioso central.
TW200819458A (en) * 2006-06-23 2008-05-01 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006071730A1 (en) * 2004-12-27 2006-07-06 Astrazeneca Ab Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders
WO2007018998A2 (en) * 2005-08-05 2007-02-15 Astrazeneca Ab Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
WO2007021309A1 (en) * 2005-08-12 2007-02-22 Astrazeneca Ab Substituted isoindolones and their use as metabotropic glutamate receptor potentiators
WO2007025709A2 (en) * 2005-08-31 2007-03-08 Novartis Ag Organic compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012064663; Proceedings of the National Academy of Sciences of the United States of America Vol.102, No.51, 2005, p.18712-18717 *
JPN6012064667; Journal of Neurophysiol. Vol.94, No.3, 2005, p.1814-1824 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020535208A (ja) * 2017-09-26 2020-12-03 プラグマ セラピューティクス 新規な複素環式化合物
JP2023178455A (ja) * 2017-09-26 2023-12-14 プラグマ セラピューティクス 新規な複素環式化合物
KR20240114499A (ko) 2023-01-17 2024-07-24 고려대학교 산학협력단 글루타민을 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물
KR102847157B1 (ko) 2023-01-17 2025-08-20 고려대학교 산학협력단 글루타민을 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물

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WO2008131439A1 (en) 2008-10-30
EP2150244A1 (en) 2010-02-10

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