JP2010520268A5 - - Google Patents

Info

Publication number

JP2010520268A5

JP2010520268A5 JP2009552266A JP2009552266A JP2010520268A5 JP 2010520268 A5 JP2010520268 A5 JP 2010520268A5 JP 2009552266 A JP2009552266 A JP 2009552266A JP 2009552266 A JP2009552266 A JP 2009552266A JP 2010520268 A5 JP2010520268 A5 JP 2010520268A5

Authority

JP

Japan

Prior art keywords

formula

compound

optionally substituted

represent

alkyl

Prior art date

2008-03-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 64
• 125000001424 substituent group Chemical group 0.000 claims 27
• 125000000217 alkyl group Chemical group 0.000 claims 19
• 125000005843 halogen group Chemical group 0.000 claims 18
• 229910052739 hydrogen Inorganic materials 0.000 claims 17
• 239000001257 hydrogen Substances 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 9
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
• 125000003118 aryl group Chemical group 0.000 claims 8
• 125000004093 cyano group Chemical group *C#N 0.000 claims 8
• 239000002671 adjuvant Substances 0.000 claims 7
• 238000006243 chemical reaction Methods 0.000 claims 7
• 239000003085 diluting agent Substances 0.000 claims 7
• 125000001072 heteroaryl group Chemical group 0.000 claims 7
• 150000002431 hydrogen Chemical class 0.000 claims 7
• 206010061218 Inflammation Diseases 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 230000004054 inflammatory process Effects 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 238000002360 preparation method Methods 0.000 claims 6
• 125000001153 fluoro group Chemical group F* 0.000 claims 5
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 208000023504 respiratory system disease Diseases 0.000 claims 5
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• 125000004429 atom Chemical group 0.000 claims 4
• 239000013066 combination product Substances 0.000 claims 4
• 229940127555 combination product Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 3
• -1 -R 3a Chemical group 0.000 claims 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
• 208000026935 allergic disease Diseases 0.000 claims 3
• 125000003277 amino group Chemical group 0.000 claims 3
• 125000001309 chloro group Chemical group Cl* 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 125000001624 naphthyl group Chemical group 0.000 claims 3
• 125000006850 spacer group Chemical group 0.000 claims 3
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
• 201000003883 Cystic fibrosis Diseases 0.000 claims 2
• 208000002193 Pain Diseases 0.000 claims 2
• 208000024780 Urticaria Diseases 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 230000036407 pain Effects 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 238000006722 reduction reaction Methods 0.000 claims 2
• 125000000335 thiazolyl group Chemical group 0.000 claims 2
• 125000001544 thienyl group Chemical group 0.000 claims 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• 125000004605 1,2,3,4-tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
• 125000004607 1,2,3,4-tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
• 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 1
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
• 208000028185 Angioedema Diseases 0.000 claims 1
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 206010010741 Conjunctivitis Diseases 0.000 claims 1
• 201000004624 Dermatitis Diseases 0.000 claims 1
• 208000005171 Dysmenorrhea Diseases 0.000 claims 1
• 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
• 206010017533 Fungal infection Diseases 0.000 claims 1
• 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
• 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
• 201000002772 Kwashiorkor Diseases 0.000 claims 1
• 208000004221 Multiple Trauma Diseases 0.000 claims 1
• 208000031888 Mycoses Diseases 0.000 claims 1
• 206010030113 Oedema Diseases 0.000 claims 1
• 208000037656 Respiratory Sounds Diseases 0.000 claims 1
• 208000025747 Rheumatic disease Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 206010040070 Septic Shock Diseases 0.000 claims 1
• 206010051222 Toxic oil syndrome Diseases 0.000 claims 1
• 208000012931 Urologic disease Diseases 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 206010047924 Wheezing Diseases 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 210000004204 blood vessel Anatomy 0.000 claims 1
• 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
• 208000015114 central nervous system disease Diseases 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 1
• 208000010643 digestive system disease Diseases 0.000 claims 1
• 210000003372 endocrine gland Anatomy 0.000 claims 1
• 208000019097 eosinophilic gastrointestinal disease Diseases 0.000 claims 1
• 230000032050 esterification Effects 0.000 claims 1
• 238000005886 esterification reaction Methods 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 125000002541 furyl group Chemical group 0.000 claims 1
• 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
• 230000007062 hydrolysis Effects 0.000 claims 1
• 238000006460 hydrolysis reaction Methods 0.000 claims 1
• 230000009610 hypersensitivity Effects 0.000 claims 1
• 125000002883 imidazolyl group Chemical group 0.000 claims 1
• 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
• 125000001041 indolyl group Chemical group 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 claims 1
• 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 1
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
• 125000000842 isoxazolyl group Chemical group 0.000 claims 1
• GWNVDXQDILPJIG-NXOLIXFESA-N leukotriene C4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O GWNVDXQDILPJIG-NXOLIXFESA-N 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 125000002971 oxazolyl group Chemical group 0.000 claims 1
• 230000004792 oxidative damage Effects 0.000 claims 1
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
• 239000000047 product Substances 0.000 claims 1
• 125000003373 pyrazinyl group Chemical group 0.000 claims 1
• 125000003226 pyrazolyl group Chemical group 0.000 claims 1
• 125000002098 pyridazinyl group Chemical group 0.000 claims 1
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
• 125000000168 pyrrolyl group Chemical group 0.000 claims 1
• 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
• 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
• 238000006268 reductive amination reaction Methods 0.000 claims 1
• 230000002829 reductive effect Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 206010039083 rhinitis Diseases 0.000 claims 1
• 208000007056 sickle cell anemia Diseases 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• 125000003831 tetrazolyl group Chemical group 0.000 claims 1
• 238000005809 transesterification reaction Methods 0.000 claims 1
• 208000014001 urinary system disease Diseases 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1