JP2010518942A - 不安定プラークまたは動脈瘤のような脆弱化した血管壁の治療 - Google Patents

不安定プラークまたは動脈瘤のような脆弱化した血管壁の治療 Download PDF

Info

Publication number
JP2010518942A
JP2010518942A JP2009550369A JP2009550369A JP2010518942A JP 2010518942 A JP2010518942 A JP 2010518942A JP 2009550369 A JP2009550369 A JP 2009550369A JP 2009550369 A JP2009550369 A JP 2009550369A JP 2010518942 A JP2010518942 A JP 2010518942A
Authority
JP
Japan
Prior art keywords
heating
ultrasonic
ultrasound
blood vessel
plaque
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009550369A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010518942A5 (enExample
Inventor
アリエル スヴァードリク，
シュムエル エイナフ，
ジーフ アロニス，
ラン コーノウスキ，
イファト ラヴィ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd filed Critical Ramot at Tel Aviv University Ltd
Publication of JP2010518942A publication Critical patent/JP2010518942A/ja
Publication of JP2010518942A5 publication Critical patent/JP2010518942A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22001—Angioplasty, e.g. PCTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22081—Treatment of vulnerable plaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Plasma & Fusion (AREA)
  • Electromagnetism (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2009550369A 2007-02-22 2008-02-21 不安定プラークまたは動脈瘤のような脆弱化した血管壁の治療 Pending JP2010518942A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90249507P 2007-02-22 2007-02-22
PCT/IL2008/000234 WO2008102363A2 (en) 2007-02-22 2008-02-21 Treating weakened vessel wall such as vulnerable plaque or aneurysms

Publications (2)

Publication Number Publication Date
JP2010518942A true JP2010518942A (ja) 2010-06-03
JP2010518942A5 JP2010518942A5 (enExample) 2011-04-07

Family

ID=39710601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009550369A Pending JP2010518942A (ja) 2007-02-22 2008-02-21 不安定プラークまたは動脈瘤のような脆弱化した血管壁の治療

Country Status (5)

Country Link
US (1) US10463886B2 (enExample)
EP (2) EP2730247B1 (enExample)
JP (1) JP2010518942A (enExample)
KR (1) KR20090121292A (enExample)
WO (1) WO2008102363A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
DE202004021954U1 (de) 2003-09-12 2013-06-19 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
WO2008049082A2 (en) 2006-10-18 2008-04-24 Minnow Medical, Inc. Inducing desirable temperature effects on body tissue
JP5559539B2 (ja) 2006-10-18 2014-07-23 べシックス・バスキュラー・インコーポレイテッド 身体組織に望ましい温度作用を誘発するシステム
EP2730247B1 (en) 2007-02-22 2017-04-26 Ramot at Tel Aviv University Ltd. Apparatus for intraluminal treatments
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
KR20110104504A (ko) 2008-11-17 2011-09-22 미노우 메디컬, 인코포레이티드 조직 토폴로지의 지식 여하에 따른 에너지의 선택적 축적
WO2010080905A2 (en) * 2009-01-08 2010-07-15 The Board Of Regents Of The University Of Texas System Real-time in vivo radiation dosimetry using scintillation detectors
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
AU2011238925B2 (en) 2010-04-09 2016-06-16 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US20120065506A1 (en) * 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
JP2013543423A (ja) 2010-10-18 2013-12-05 カーディオソニック リミテッド 組織治療
US8696581B2 (en) 2010-10-18 2014-04-15 CardioSonic Ltd. Ultrasound transducer and uses thereof
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
US20120259269A1 (en) 2011-04-08 2012-10-11 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
WO2013157011A2 (en) * 2012-04-18 2013-10-24 CardioSonic Ltd. Tissue treatment
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US9592027B2 (en) 2013-03-14 2017-03-14 Volcano Corporation System and method of adventitial tissue characterization
EP3932470B1 (en) 2013-03-15 2023-07-12 Medtronic Ardian Luxembourg S.à.r.l. Controlled neuromodulation systems
WO2014188430A2 (en) 2013-05-23 2014-11-27 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
WO2016084081A2 (en) 2014-11-26 2016-06-02 Sonievie Ltd. Devices and methods for pulmonary hypertension treatment
US10779964B2 (en) * 2015-03-15 2020-09-22 Board Of Trustees Of The Leland Stanford Junior University Methods, devices, and compositions for treating abdominal aortic aneurysms
US20200238107A1 (en) 2017-03-20 2020-07-30 Sonie Vie Ltd. Pulmonary hypertension treatment method and/or system
WO2019034687A1 (en) * 2017-08-15 2019-02-21 Koninklijke Philips N.V. INTRACARDIAC TREATMENT AND ULTRASONIC DIAGNOSTIC DEVICE

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475210B1 (en) * 2000-02-11 2002-11-05 Medventure Technology Corp Light treatment of vulnerable atherosclerosis plaque
JP2004503277A (ja) * 2000-03-08 2004-02-05 ファーマソニックス，インコーポレイテッド プラーク安定化のための方法、システムおよびキット
WO2005030295A2 (en) * 2003-09-24 2005-04-07 Therus Corporation Insertable ultrasound probes, systems, and methods for thermal therapy
WO2005076729A2 (en) * 2004-02-12 2005-08-25 Neurosonix Ltd. Acoustic control of emboli in vivo
US20060058711A1 (en) * 2000-07-13 2006-03-16 Prorhythm, Inc. Energy application with inflatable annular lens

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867962A (en) 1988-02-26 1989-09-19 Neorx Corporation Functionally specific antibodies
US5053006A (en) * 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
US6537306B1 (en) 1992-11-13 2003-03-25 The Regents Of The University Of California Method of manufacture of a transurethral ultrasound applicator for prostate gland thermal therapy
US6203775B1 (en) 1993-03-19 2001-03-20 The General Hospital Corporation Chelating polymers for labeling of proteins
US5405322A (en) 1993-08-12 1995-04-11 Boston Scientific Corporation Method for treating aneurysms with a thermal source
US5585637A (en) 1995-06-09 1996-12-17 Adac Laboratories Multi-head nuclear medicine camera for dual SPECT and PET imaging
AU712539B2 (en) * 1996-01-08 1999-11-11 Biosense, Inc. Methods and apparatus for myocardial revascularization
US5921954A (en) 1996-07-10 1999-07-13 Mohr, Jr.; Lawrence G. Treating aneurysms by applying hardening/softening agents to hardenable/softenable substances
WO1997044089A1 (en) 1996-05-17 1997-11-27 Biosense Inc. Self-aligning catheter
US7052493B2 (en) * 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US6071303A (en) 1996-12-08 2000-06-06 Hearten Medical, Inc. Device for the treatment of infarcted tissue and method of treating infarcted tissue
US5906580A (en) 1997-05-05 1999-05-25 Creare Inc. Ultrasound system and method of administering ultrasound including a plurality of multi-layer transducer elements
EP0989822A4 (en) 1997-06-23 2004-07-28 Focus Surgery Inc METHODS AND DEVICES FOR CREATING ACOUSTIC HEMOSTASIS
US6514249B1 (en) 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
JP3636579B2 (ja) 1997-11-04 2005-04-06 キヤノン株式会社 光電変換装置、光電変換装置の駆動方法及びその光電変換装置を有するシステム
US6026317A (en) 1998-02-06 2000-02-15 Baylor College Of Medicine Myocardial perfusion imaging during coronary vasodilation with selective adenosine A2 receptor agonists
AU3865699A (en) 1998-04-22 1999-11-08 Cardiosynopsis, Inc. Apparatus to electrosurgically treating an aneurysm
JP4318774B2 (ja) * 1998-12-03 2009-08-26 株式会社日立メディコ 磁気共鳴画像診断装置
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US6235024B1 (en) 1999-06-21 2001-05-22 Hosheng Tu Catheters system having dual ablation capability
JP4576521B2 (ja) * 1999-06-25 2010-11-10 ハンセン メディカル， インコーポレイテッド 組織を処置するための装置および方法
US6626855B1 (en) * 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US7184827B1 (en) 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
US7373197B2 (en) 2000-03-03 2008-05-13 Intramedical Imaging, Llc Methods and devices to expand applications of intraoperative radiation probes
US20030069525A1 (en) 2000-03-08 2003-04-10 Pharmasonics, Inc. Methods, systems, and kits for plaque stabilization
US6597940B2 (en) 2000-12-01 2003-07-22 Neomed Technologies Methods of detecting occlusion of the coronary artery system and imaging the heart
US20020103429A1 (en) 2001-01-30 2002-08-01 Decharms R. Christopher Methods for physiological monitoring, training, exercise and regulation
US7105824B2 (en) 2002-05-09 2006-09-12 Neurologica, Corp. High resolution photon emission computed tomographic imaging tool
US20030055360A1 (en) 2001-09-05 2003-03-20 Zeleznik Matthew A. Minimally invasive sensing system for measuring rigidity of anatomical matter
US20030060813A1 (en) * 2001-09-22 2003-03-27 Loeb Marvin P. Devices and methods for safely shrinking tissues surrounding a duct, hollow organ or body cavity
US6736809B2 (en) 2001-09-26 2004-05-18 Cryocath Technologies Inc. Method and device for treatment of aneurysms
JP2005508171A (ja) 2001-11-02 2005-03-31 タノックス インコーポレーテッド Ｂ細胞悪性病変の診断及び予防に用いるためのｂ細胞リンパ腫特異抗原
US6928142B2 (en) 2002-10-18 2005-08-09 Koninklijke Philips Electronics N.V. Non-invasive plaque detection using combined nuclear medicine and x-ray system
GB0228960D0 (en) 2002-12-11 2003-01-15 Mirada Solutions Ltd Improvements in or relating to processing systems
US7686802B2 (en) * 2003-03-28 2010-03-30 C.R. Bard, Inc. Junction of catheter tip and electrode
US7294125B2 (en) * 2003-08-22 2007-11-13 Scimed Life Systems, Inc. Methods of delivering energy to body portions to produce a therapeutic response
US20050049487A1 (en) 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
US20050240249A1 (en) 2003-10-28 2005-10-27 Hosheng Tu Methods for treating mitral valve annulus with biodegradable compression element
US7318804B2 (en) * 2003-12-09 2008-01-15 The Regents Of The University Of Michigan Methods and systems for measuring mechanical property of a vascular wall and method and system for determining health of a vascular structure
US8586932B2 (en) 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
US9627097B2 (en) 2004-03-02 2017-04-18 General Electric Company Systems, methods and apparatus for infusion of radiopharmaceuticals
EP1778957A4 (en) 2004-06-01 2015-12-23 Biosensors Int Group Ltd OPTIMIZING THE MEASUREMENT OF RADIOACTIVE RADIATION ON SPECIAL BODY STRUCTURES
US8409099B2 (en) 2004-08-26 2013-04-02 Insightec Ltd. Focused ultrasound system for surrounding a body tissue mass and treatment method
US7283654B2 (en) 2004-08-26 2007-10-16 Lumeniq, Inc. Dynamic contrast visualization (DCV)
WO2008059489A2 (en) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Radioimaging applications of and novel formulations of teboroxime
US20060224090A1 (en) 2005-03-29 2006-10-05 Isaac Ostrovsky Apparatus and method for stiffening tissue
US20070016039A1 (en) 2005-06-21 2007-01-18 Insightec-Image Guided Treatment Ltd. Controlled, non-linear focused ultrasound treatment
EP1909853B1 (en) 2005-07-19 2015-03-18 Biosensors International Group, Ltd. Imaging protocols
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
US7601966B2 (en) 2006-06-28 2009-10-13 Spectrum Dynamics Llc Imaging techniques for reducing blind spots
EP2730247B1 (en) 2007-02-22 2017-04-26 Ramot at Tel Aviv University Ltd. Apparatus for intraluminal treatments

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475210B1 (en) * 2000-02-11 2002-11-05 Medventure Technology Corp Light treatment of vulnerable atherosclerosis plaque
JP2004503277A (ja) * 2000-03-08 2004-02-05 ファーマソニックス，インコーポレイテッド プラーク安定化のための方法、システムおよびキット
US20060058711A1 (en) * 2000-07-13 2006-03-16 Prorhythm, Inc. Energy application with inflatable annular lens
WO2005030295A2 (en) * 2003-09-24 2005-04-07 Therus Corporation Insertable ultrasound probes, systems, and methods for thermal therapy
WO2005076729A2 (en) * 2004-02-12 2005-08-25 Neurosonix Ltd. Acoustic control of emboli in vivo
JP2007521908A (ja) * 2004-02-12 2007-08-09 ニューロソニック リミティド 生体における塞栓音波制御

Also Published As

Publication number Publication date
EP2112911A2 (en) 2009-11-04
US20100081933A1 (en) 2010-04-01
EP2730247A1 (en) 2014-05-14
WO2008102363A3 (en) 2009-11-26
WO2008102363A2 (en) 2008-08-28
HK1137918A1 (en) 2010-08-13
KR20090121292A (ko) 2009-11-25
EP2112911A4 (en) 2011-04-06
EP2730247B1 (en) 2017-04-26
US10463886B2 (en) 2019-11-05
EP2112911B1 (en) 2014-10-01

Similar Documents

Publication Publication Date Title
US10463886B2 (en) Treating weakened vessel wall such as vulnerable plaque or aneurysms
JP6571719B2 (ja) 経皮的超音波腎神経除去による高血圧症を治療するための方法及び装置
KR101640424B1 (ko) 영상 유도 플라크 절제
US6451044B1 (en) Method and apparatus for heating inflammed tissue
US20130211396A1 (en) Tissue treatment
US20140180077A1 (en) Tissue ablation catheter and methods of ablating tissue
WO2010062769A1 (en) Device for irradiating an internal body surface
HK1137918B (en) Apparatus for treating blood vessels by ultrasound
Zeng et al. Acoustic hemostasis of porcine superficial femoral artery: Simulation and in-vivo experimental studies
HK1145072B (en) A system for non-invasively and a controller

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110215

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110215

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120925

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20120928

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121225

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130315

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130612

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130816

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131113

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140110

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140530