JP2010518164A5 - - Google Patents

Info

Publication number

JP2010518164A5

JP2010518164A5 JP2009549615A JP2009549615A JP2010518164A5 JP 2010518164 A5 JP2010518164 A5 JP 2010518164A5 JP 2009549615 A JP2009549615 A JP 2009549615A JP 2009549615 A JP2009549615 A JP 2009549615A JP 2010518164 A5 JP2010518164 A5 JP 2010518164A5

Authority

JP

Japan

Prior art keywords

sugar

group

galactose

maltose

fructose

Prior art date

2008-02-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 23
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 21
• 229930091371 Fructose Natural products 0.000 claims 21
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 21
• 239000005715 Fructose Substances 0.000 claims 21
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 21
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 21
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 21
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 21
• 229930182830 galactose Natural products 0.000 claims 21
• 229940074391 gallic acid Drugs 0.000 claims 21
• 239000008103 glucose Substances 0.000 claims 21
• 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 21
• 229910052739 hydrogen Inorganic materials 0.000 claims 21
• 239000001257 hydrogen Substances 0.000 claims 21
• 150000002431 hydrogen Chemical class 0.000 claims 18
• 239000003814 drug Substances 0.000 claims 17
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 15
• 229940079593 drug Drugs 0.000 claims 14
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 239000002207 metabolite Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 210000005155 neural progenitor cell Anatomy 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 208000004793 anterograde amnesia Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000004694 hippocampus damage Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000004060 metabolic process Effects 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 230000004766 neurogenesis Effects 0.000 claims 1
• 230000001272 neurogenic effect Effects 0.000 claims 1
• 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
• 201000009570 retrograde amnesia Diseases 0.000 claims 1
• 0 *c1ccc(C(C(C(c2c3*=C)=O)O)Oc2c(*)c(*)c3N)cc1C=[U] Chemical compound *c1ccc(C(C(C(c2c3*=C)=O)O)Oc2c(*)c(*)c3N)cc1C=[U] 0.000 description 3