JP2010518154A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010518154A5 JP2010518154A5 JP2009549466A JP2009549466A JP2010518154A5 JP 2010518154 A5 JP2010518154 A5 JP 2010518154A5 JP 2009549466 A JP2009549466 A JP 2009549466A JP 2009549466 A JP2009549466 A JP 2009549466A JP 2010518154 A5 JP2010518154 A5 JP 2010518154A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- active ingredient
- disease
- tamoxifen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 239000004480 active ingredient Substances 0.000 claims 17
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229960001603 tamoxifen Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 230000007423 decrease Effects 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical group CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 4
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 4
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 4
- 229960003009 clopidogrel Drugs 0.000 claims 4
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 208000019553 vascular disease Diseases 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 206010059245 Angiopathy Diseases 0.000 claims 3
- 229940127218 antiplatelet drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010051787 Multiple organ transplant rejection Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000023750 transforming growth factor beta production Effects 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- JJKOTMDDZAJTGQ-DQSJHHFOSA-N Idoxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN2CCCC2)=CC=1)/C1=CC=C(I)C=C1 JJKOTMDDZAJTGQ-DQSJHHFOSA-N 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- BXBJCCCIFADZBU-UHFFFAOYSA-J copper aspirinate Chemical compound [Cu+2].[Cu+2].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O BXBJCCCIFADZBU-UHFFFAOYSA-J 0.000 claims 1
- 229950004203 droloxifene Drugs 0.000 claims 1
- 229960001123 epoprostenol Drugs 0.000 claims 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229950002248 idoxifene Drugs 0.000 claims 1
- 229960002240 iloprost Drugs 0.000 claims 1
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 1
- 239000003055 low molecular weight heparin Substances 0.000 claims 1
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
- 229960004622 raloxifene Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical group C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 229960003425 tirofiban Drugs 0.000 claims 1
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 claims 1
- 229960005026 toremifene Drugs 0.000 claims 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0702871.5A GB0702871D0 (en) | 2007-02-14 | 2007-02-14 | Improved compositions and combinations 1 |
| PCT/GB2008/000451 WO2008099144A2 (en) | 2007-02-14 | 2008-02-07 | Tgf-beta stimulant and further agent to reduce side effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518154A JP2010518154A (ja) | 2010-05-27 |
| JP2010518154A5 true JP2010518154A5 (https=) | 2011-03-31 |
Family
ID=37908631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549466A Pending JP2010518154A (ja) | 2007-02-14 | 2008-02-07 | 副作用を減少させる、ｔｇｆ−ベータ刺激因子及び追加の剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100099642A1 (https=) |
| EP (1) | EP2121020A2 (https=) |
| JP (1) | JP2010518154A (https=) |
| CN (1) | CN101668543A (https=) |
| CA (1) | CA2678127A1 (https=) |
| GB (1) | GB0702871D0 (https=) |
| RU (1) | RU2009134039A (https=) |
| WO (1) | WO2008099144A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2939314A1 (fr) * | 2008-12-04 | 2010-06-11 | Univ Victor Segalen Bordeaux 2 | Nouvelles compositions et methodes pour la potentialisation des signaux d'apoptose dans les cellules tumorales |
| US20110136858A1 (en) * | 2009-12-04 | 2011-06-09 | Grainger David J | Preferred Combination Therapy |
| GB2475907A (en) | 2009-12-04 | 2011-06-08 | Tcp Innovations Ltd | Composition comprising a mixture of clopidogrel and droloxifene |
| HRP20201384T1 (hr) | 2014-01-01 | 2020-11-27 | Medivation Technologies Llc | Spojevi i postupci njihove upotrebe |
| CN104211778A (zh) * | 2014-09-28 | 2014-12-17 | 苏州普罗达生物科技有限公司 | 一种转化生长因子β1激动剂多肽及其制备方法、应用 |
| CN104311631A (zh) * | 2014-09-28 | 2015-01-28 | 苏州普罗达生物科技有限公司 | 转化生长因子β1激动剂多肽及其制备方法、应用 |
| US20220125744A1 (en) * | 2018-11-07 | 2022-04-28 | Health Research, Inc. | Exploiting estrogen receptor beta and tp53 interaction as a new therapeutic strategy for cancer |
| CN116152157B (zh) * | 2022-11-28 | 2026-02-27 | 苏州大学 | 基于肿瘤组织灌注影像学特征的生物标志物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251920B1 (en) * | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6117911A (en) * | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
-
2007
- 2007-02-14 GB GBGB0702871.5A patent/GB0702871D0/en not_active Ceased
-
2008
- 2008-02-07 US US12/527,337 patent/US20100099642A1/en not_active Abandoned
- 2008-02-07 RU RU2009134039/15A patent/RU2009134039A/ru not_active Application Discontinuation
- 2008-02-07 EP EP08709352A patent/EP2121020A2/en not_active Withdrawn
- 2008-02-07 CN CN200880009702A patent/CN101668543A/zh active Pending
- 2008-02-07 JP JP2009549466A patent/JP2010518154A/ja active Pending
- 2008-02-07 CA CA002678127A patent/CA2678127A1/en not_active Abandoned
- 2008-02-07 WO PCT/GB2008/000451 patent/WO2008099144A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010518154A5 (https=) | ||
| AU2023229524B2 (en) | Combination therapy of tetracyclic quinolone analogs for treating cancer | |
| AU2019232879B2 (en) | Treatment or prevention of cardiovascular events via the administration of a colchicine derivative | |
| RU2005104418A (ru) | Фармацевтические композиции для лечения неврологических расстройств, содержащие декстрометорфан и квинидин | |
| RU2009134039A (ru) | Стимуляторы tgf-бета и другие агенты для уменьшения побочных эффектов | |
| JP2012525393A5 (https=) | ||
| JP2018517686A5 (https=) | ||
| CN1255854A (zh) | 1,2,4－三唑并[1,5－c]嘧啶杂环类似物在制备用于治疗心血管疾病的药物中的用途 | |
| JP2008255121A (ja) | 抗ｂ型肝炎ウイルス活性を有するヌクレオシド | |
| JP2021514373A5 (https=) | ||
| JP3162071B2 (ja) | サイトカイン阻害剤 | |
| JP2024546605A (ja) | がんを治療するための併用療法の使用 | |
| JP2011518168A5 (https=) | ||
| AU702618B2 (en) | 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2 -cyclopentene-1-methanol succinate as antiviral agent | |
| AU2014231716A1 (en) | Oxprenolol compositions for treating cancer | |
| EP2254570B1 (en) | Combination comprising paclitaxel for treating ovarian cancer | |
| CA3069010A1 (en) | Methods of treating myelodysplastic syndrome | |
| FI3713576T3 (fi) | Yhdiste kaavan (i) mukaan ja ponatinibi käytettäväksi bcr-abl-mutaatioiden kanssa esiintyvän kroonisen myelooisen leukemian hoidossa | |
| MX2010012540A (es) | Derivados de imidazo[2,1-b]quinazolin-2-ona y su uso como agentes para inhibir la agregación plaquetaria. | |
| JP4648193B2 (ja) | 医薬組成物 | |
| TWI481611B (zh) | 碳環核苷及其醫藥用途及組合物 | |
| JP2004528311A5 (https=) | ||
| US12409179B2 (en) | Pharmaceutical combination of pimozide and methotrexate and use thereof | |
| JP7735862B2 (ja) | 代謝異常を伴う疾患又は症候群における筋力低下症状の改善剤又は予防剤 | |
| CN1681533A (zh) | 用于治疗动脉硬化的药用组合物 |