JP2010517759A - 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法 - Google Patents
水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法 Download PDFInfo
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- JP2010517759A JP2010517759A JP2009549040A JP2009549040A JP2010517759A JP 2010517759 A JP2010517759 A JP 2010517759A JP 2009549040 A JP2009549040 A JP 2009549040A JP 2009549040 A JP2009549040 A JP 2009549040A JP 2010517759 A JP2010517759 A JP 2010517759A
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- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
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- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
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- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
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- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88895407P | 2007-02-09 | 2007-02-09 | |
| PCT/SE2008/000107 WO2008097165A1 (en) | 2007-02-09 | 2008-02-08 | Process for preparation of a stable dispersion of solid amorphous submicron particles in an aqueous medium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010517759A true JP2010517759A (ja) | 2010-05-27 |
| JP2010517759A5 JP2010517759A5 (enExample) | 2011-03-24 |
Family
ID=39681953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549040A Pending JP2010517759A (ja) | 2007-02-09 | 2008-02-08 | 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100068287A1 (enExample) |
| EP (1) | EP2109443A4 (enExample) |
| JP (1) | JP2010517759A (enExample) |
| CN (1) | CN101605533B (enExample) |
| WO (1) | WO2008097165A1 (enExample) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| FR2651680B1 (fr) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
| US5110717A (en) * | 1990-12-17 | 1992-05-05 | Eastman Kodak Company | Stability improvement of amorphous particle dispersions |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| DE4327063A1 (de) * | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
| DE4329446A1 (de) * | 1993-09-01 | 1995-03-02 | Basf Ag | Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen |
| GB9319129D0 (en) * | 1993-09-15 | 1993-11-03 | Dowelanco Ltd | Storage and dilution of stable aqueous dispersions |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| WO1999033558A1 (en) * | 1997-12-29 | 1999-07-08 | Universite De Geneve | Method for producing an aqueous colloidal dispersion of nanoparticles |
| US6375986B1 (en) * | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
| US6267989B1 (en) * | 1999-03-08 | 2001-07-31 | Klan Pharma International Ltd. | Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions |
| WO2001002087A1 (en) * | 1999-07-06 | 2001-01-11 | Universite De Geneve Laboratoire De Pharmacie Galenique | Method for producing aqueous colloidal dispersions of nanoparticles |
| AU5711501A (en) * | 2000-04-20 | 2001-11-07 | Rtp Pharma Inc | Improved water-insoluble drug particle process |
| EP1416917B1 (en) * | 2001-08-06 | 2007-06-27 | AstraZeneca AB | Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct) |
| AU2003235686A1 (en) * | 2002-01-14 | 2003-07-30 | Dow Global Technologies Inc. | Drug nanoparticles from template emulsions |
| ES2305434T3 (es) * | 2002-02-01 | 2008-11-01 | Pfizer Products Inc. | Composiciones framaceuticas de dispersiones amorfas de farmacos y materiales que forman microfases lipofilas. |
| US20040258757A1 (en) * | 2002-07-16 | 2004-12-23 | Elan Pharma International, Ltd. | Liquid dosage compositions of stable nanoparticulate active agents |
| GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
| US7390505B2 (en) * | 2003-01-31 | 2008-06-24 | Elan Pharma International, Ltd. | Nanoparticulate topiramate formulations |
| US20060198856A1 (en) * | 2005-03-01 | 2006-09-07 | Keith Whitehead | Ibuprofen suspension stabilized with docusate sodium |
| WO2007021228A1 (en) * | 2005-08-12 | 2007-02-22 | Astrazeneca Ab | Process |
| WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
-
2008
- 2008-02-08 EP EP08712705A patent/EP2109443A4/en not_active Withdrawn
- 2008-02-08 CN CN2008800044661A patent/CN101605533B/zh not_active Expired - Fee Related
- 2008-02-08 JP JP2009549040A patent/JP2010517759A/ja active Pending
- 2008-02-08 US US12/524,882 patent/US20100068287A1/en not_active Abandoned
- 2008-02-08 WO PCT/SE2008/000107 patent/WO2008097165A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20100068287A1 (en) | 2010-03-18 |
| CN101605533A (zh) | 2009-12-16 |
| EP2109443A1 (en) | 2009-10-21 |
| WO2008097165A1 (en) | 2008-08-14 |
| CN101605533B (zh) | 2012-04-18 |
| EP2109443A4 (en) | 2012-08-22 |
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