JP2010513542A5 - - Google Patents
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- Publication number
- JP2010513542A5 JP2010513542A5 JP2009542994A JP2009542994A JP2010513542A5 JP 2010513542 A5 JP2010513542 A5 JP 2010513542A5 JP 2009542994 A JP2009542994 A JP 2009542994A JP 2009542994 A JP2009542994 A JP 2009542994A JP 2010513542 A5 JP2010513542 A5 JP 2010513542A5
- Authority
- JP
- Japan
- Prior art keywords
- styrene
- block copolymer
- drug
- styrene block
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 10
- 229920001971 elastomer Polymers 0.000 claims description 7
- 239000000806 elastomer Substances 0.000 claims description 7
- 229920006132 styrene block copolymer Polymers 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 238000012377 drug delivery Methods 0.000 claims description 4
- 239000003732 agents acting on the eye Substances 0.000 claims description 3
- 229940023490 ophthalmic product Drugs 0.000 claims description 3
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims 4
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 claims 4
- -1 styrene-ethylene-butylene-styrene Chemical class 0.000 claims 4
- 206010029113 Neovascularisation Diseases 0.000 claims 3
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 claims 2
- 208000002691 Choroiditis Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000001344 Macular Edema Diseases 0.000 claims 2
- 208000003971 Posterior uveitis Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 229960000397 bevacizumab Drugs 0.000 claims 2
- GJKZSOHUVOQISW-UHFFFAOYSA-N buta-1,3-diene;2-methylbuta-1,3-diene;styrene Chemical compound C=CC=C.CC(=C)C=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 GJKZSOHUVOQISW-UHFFFAOYSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 229960003407 pegaptanib Drugs 0.000 claims 2
- 229960003876 ranibizumab Drugs 0.000 claims 2
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 claims 2
- 206010058202 Cystoid macular oedema Diseases 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 claims 1
- 229940127361 Receptor Tyrosine Kinase Inhibitors Drugs 0.000 claims 1
- 208000007135 Retinal Neovascularization Diseases 0.000 claims 1
- 201000007527 Retinal artery occlusion Diseases 0.000 claims 1
- 206010038848 Retinal detachment Diseases 0.000 claims 1
- 206010038910 Retinitis Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 1
- 206010038935 Retinopathy sickle cell Diseases 0.000 claims 1
- 206010040925 Skin striae Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 239000000030 antiglaucoma agent Substances 0.000 claims 1
- 229960005475 antiinfective agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010206 cystoid macular edema Diseases 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 231100000040 eye damage Toxicity 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 201000003142 neovascular glaucoma Diseases 0.000 claims 1
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 230000006785 proliferative vitreoretinopathy Effects 0.000 claims 1
- 230000004264 retinal detachment Effects 0.000 claims 1
- 208000032253 retinal ischemia Diseases 0.000 claims 1
- 239000000790 retinal pigment Substances 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 7
- 238000001125 extrusion Methods 0.000 description 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000007666 vacuum forming Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85814306P | 2006-12-18 | 2006-12-18 | |
| US60/858,143 | 2006-12-18 | ||
| PCT/US2007/084009 WO2008076544A2 (en) | 2006-12-18 | 2007-11-08 | Devices and methods for ophthalmic drug delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513542A JP2010513542A (ja) | 2010-04-30 |
| JP2010513542A5 true JP2010513542A5 (enExample) | 2013-05-23 |
| JP5323720B2 JP5323720B2 (ja) | 2013-10-23 |
Family
ID=39265276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542994A Expired - Fee Related JP5323720B2 (ja) | 2006-12-18 | 2007-11-08 | 眼用薬物送達のためのデバイスおよび方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20080145406A1 (enExample) |
| EP (1) | EP2091481A2 (enExample) |
| JP (1) | JP5323720B2 (enExample) |
| KR (1) | KR20090098870A (enExample) |
| CN (2) | CN101563051A (enExample) |
| AR (1) | AR063619A1 (enExample) |
| AU (1) | AU2007334248B2 (enExample) |
| BR (1) | BRPI0720431A2 (enExample) |
| CA (1) | CA2670944A1 (enExample) |
| MX (1) | MX2009006146A (enExample) |
| TW (1) | TW200829293A (enExample) |
| WO (1) | WO2008076544A2 (enExample) |
| ZA (1) | ZA200903649B (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US8167855B2 (en) * | 2003-08-26 | 2012-05-01 | Vista Scientific Llc | Ocular drug delivery device |
| EP3168304A1 (en) * | 2003-08-27 | 2017-05-17 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
| US9510844B2 (en) | 2007-11-13 | 2016-12-06 | Mgd Innovations, Llc | Gland or duct diagnostic and treatment methods and related apparatus |
| EP2222355B1 (en) * | 2007-11-13 | 2014-09-03 | Mgd Innovations, Llc | Meibomian gland intraductal diagnostic and treatment methods and related apparatus |
| US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| CA2723588A1 (en) | 2008-05-12 | 2009-11-19 | University Of Utah Research Foundation | Intraocular drug delivery device and associated uses |
| US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| CA2728623A1 (en) * | 2008-06-24 | 2010-01-21 | Qlt Plug Delivery, Inc. | Combination treatment of glaucoma |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| SG173167A1 (en) | 2009-01-29 | 2011-08-29 | Forsight Labs Llc | Posterior segment drug delivery |
| WO2010101758A1 (en) * | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Peri-corneal drug delivery device |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| EP4289416A3 (en) | 2009-05-18 | 2024-01-03 | Dose Medical Corporation | Drug eluting ocular implant |
| AU2010256558B2 (en) | 2009-06-03 | 2013-10-03 | Forsight Labs, Llc | Anterior segment drug delivery |
| US8939948B2 (en) | 2010-06-01 | 2015-01-27 | Forsight Vision5, Inc. | Ocular insert apparatus and methods |
| SI2600812T1 (sl) | 2010-08-05 | 2021-12-31 | ForSight Vision4, Inc., | Naprava za zdravljenje očesa |
| JP6111194B2 (ja) | 2010-08-05 | 2017-04-05 | フォーサイト・ビジョン フォー・インコーポレーテッド | 組み合わせ薬物送達方法および装置 |
| SG187730A1 (en) | 2010-08-05 | 2013-03-28 | Forsight Vision 4 Inc | Injector apparatus and method for drug delivery |
| WO2012068549A2 (en) | 2010-11-19 | 2012-05-24 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| US9668915B2 (en) | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
| KR20140026362A (ko) * | 2010-12-29 | 2014-03-05 | 제이드 테라퓨틱스, 인크. | 안과 약물 전달 시스템 |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| US10398592B2 (en) | 2011-06-28 | 2019-09-03 | Forsight Vision4, Inc. | Diagnostic methods and apparatus |
| EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | DISPOSAL OF SMALL MOLECULES THROUGH AN IMPLANTABLE THERAPEUTIC DEVICE |
| WO2013040238A2 (en) | 2011-09-13 | 2013-03-21 | Vista Scientific Llc | Sustained release ocular drug delivery devices and methods of manufacture |
| LT2755600T (lt) | 2011-09-16 | 2021-04-26 | Forsight Vision4, Inc. | Skysčio pakeitimo aparatas |
| US9510972B2 (en) * | 2012-01-04 | 2016-12-06 | Sight Sciences, Inc. | Dry eye treatment systems |
| US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
| US9642742B2 (en) | 2012-10-02 | 2017-05-09 | Harold D. Mansfield | Eye drop applicator and drop transfer method |
| SI2911623T1 (sl) | 2012-10-26 | 2019-12-31 | Forsight Vision5, Inc. | Oftalmični sistem za podaljšano sproščanje zdravila v oko |
| WO2014124487A1 (en) | 2013-02-18 | 2014-08-21 | Vegenics Pty Limited | Ligand binding molecules and uses thereof |
| US9968603B2 (en) | 2013-03-14 | 2018-05-15 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| US9526654B2 (en) | 2013-03-28 | 2016-12-27 | Forsight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
| SG10201708882TA (en) | 2013-07-12 | 2017-12-28 | Ophthotech Corp | Methods for treating or preventing ophthalmological conditions |
| US20150342875A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2016011191A1 (en) | 2014-07-15 | 2016-01-21 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
| JP2017524034A (ja) | 2014-08-08 | 2017-08-24 | フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． | 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 |
| EP3188688B1 (en) * | 2014-09-06 | 2021-11-03 | Integral Biosystems LLC | Methods and biocompatible compositions to achieve sustained drug release in the eye |
| US10500091B2 (en) | 2014-11-10 | 2019-12-10 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| WO2016187426A1 (en) | 2015-05-19 | 2016-11-24 | Amorphex Therapeutics Llc | A device that delivers a sustained low-dose of a myopia-suppressing drug |
| WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| MX2018006234A (es) | 2015-11-20 | 2018-08-14 | Forsight Vision4 Inc | Estructuras porosas para dispositivos de suministro de medicamentos de liberacion prolongada. |
| CN113017981B (zh) | 2016-04-05 | 2023-07-25 | 弗赛特影像4股份有限公司 | 药物递送装置 |
| WO2017184881A1 (en) | 2016-04-20 | 2017-10-26 | Harold Alexander Heitzmann | Bioresorbable ocular drug delivery device |
| US10603210B1 (en) | 2017-02-02 | 2020-03-31 | Mgd Innovations, Llc | Meibomian gland probing with blood product injection |
| CN115607358A (zh) | 2017-11-21 | 2023-01-17 | 弗赛特影像4股份有限公司 | 用于可扩展端口递送系统的流体交换装置及使用方法 |
| CA3087238A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| SG11202005949UA (en) | 2018-05-24 | 2020-07-29 | Celanese Eva Performance Polymers Corp | Implantable device for sustained release of a macromolecular drug compound |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
| CN114652826B (zh) * | 2022-01-24 | 2022-10-14 | 景泽生物医药(合肥)有限公司 | 抗egfr抗体的用途 |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206692A1 (es) * | 1972-12-27 | 1976-08-13 | Alza Corp | Agente dispensador de liberacion sostenida de substancias activas |
| US5178635A (en) * | 1992-05-04 | 1993-01-12 | Allergan, Inc. | Method for determining amount of medication in an implantable device |
| US5904144A (en) * | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
| WO1999046327A1 (en) * | 1998-03-11 | 1999-09-16 | The Dow Chemical Company | STRUCTURES AND FABRICATED ARTICLES HAVING SHAPE MEMORY MADE FROM α-OLEFIN/VINYL OR VINYLIDENE AROMATIC AND/OR HINDERED ALIPHATIC VINYL OR VINYLIDENE INTERPOLYMERS |
| KR100732262B1 (ko) * | 1999-10-21 | 2007-06-25 | 알콘, 인코퍼레이티드 | 약물 전달 장치 |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| AU7141701A (en) * | 2000-08-30 | 2002-03-13 | Univ Johns Hopkins | Devices for intraocular drug delivery |
| CA2433032C (en) * | 2001-01-03 | 2008-11-25 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with coated drug cores |
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| CN1674913A (zh) * | 2002-08-05 | 2005-09-28 | 爱尔康公司 | 乙酸阿奈可他用于在年龄相关性黄斑变性患者中保护视力的用途 |
| US20040219198A1 (en) * | 2003-05-01 | 2004-11-04 | 3M Innovative Properties Company | Transdermal drug delivery device with multilayer backing |
| US7794498B2 (en) * | 2003-12-05 | 2010-09-14 | Innolene Llc | Ocular lens |
| WO2005055972A2 (en) * | 2003-12-09 | 2005-06-23 | Nanon A/S | A drug delivery device and a method of producing it |
| US20050181015A1 (en) * | 2004-02-12 | 2005-08-18 | Sheng-Ping (Samuel) Zhong | Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles |
| DE602005015564D1 (de) * | 2004-04-06 | 2009-09-03 | Surmodics Inc | Beschichtungszusammensetzungen für bioaktive mittel |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| EP1898891A2 (en) * | 2005-05-13 | 2008-03-19 | Alza Corporation | Multilayer drug delivery system with barrier against antagonist exposure |
| US10029034B2 (en) * | 2005-12-15 | 2018-07-24 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Drug-eluting articles with improved drug release profiles |
-
2007
- 2007-11-08 AU AU2007334248A patent/AU2007334248B2/en not_active Ceased
- 2007-11-08 CN CNA2007800456351A patent/CN101563051A/zh active Pending
- 2007-11-08 ZA ZA200903649A patent/ZA200903649B/xx unknown
- 2007-11-08 TW TW096142198A patent/TW200829293A/zh unknown
- 2007-11-08 BR BRPI0720431-0A patent/BRPI0720431A2/pt not_active IP Right Cessation
- 2007-11-08 CN CN201310628215.3A patent/CN103622778A/zh active Pending
- 2007-11-08 MX MX2009006146A patent/MX2009006146A/es not_active Application Discontinuation
- 2007-11-08 KR KR1020097014324A patent/KR20090098870A/ko not_active Abandoned
- 2007-11-08 EP EP07864078A patent/EP2091481A2/en not_active Withdrawn
- 2007-11-08 CA CA002670944A patent/CA2670944A1/en not_active Abandoned
- 2007-11-08 JP JP2009542994A patent/JP5323720B2/ja not_active Expired - Fee Related
- 2007-11-08 WO PCT/US2007/084009 patent/WO2008076544A2/en not_active Ceased
- 2007-11-08 AR ARP070104978A patent/AR063619A1/es not_active Application Discontinuation
- 2007-11-08 US US11/936,842 patent/US20080145406A1/en not_active Abandoned
-
2010
- 2010-05-07 US US12/775,551 patent/US20100266664A1/en not_active Abandoned
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