JP2010502674A - カリウムチャンネル調節剤として有用なピリジニル−ピリミジン誘導体 - Google Patents
カリウムチャンネル調節剤として有用なピリジニル−ピリミジン誘導体 Download PDFInfo
- Publication number
- JP2010502674A JP2010502674A JP2009527140A JP2009527140A JP2010502674A JP 2010502674 A JP2010502674 A JP 2010502674A JP 2009527140 A JP2009527140 A JP 2009527140A JP 2009527140 A JP2009527140 A JP 2009527140A JP 2010502674 A JP2010502674 A JP 2010502674A
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- JP
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- Prior art keywords
- alkyl
- phenyl
- chloro
- methyl
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- VBSJJTJCXKEDDH-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(6-chloropyridin-2-yl)pyrimidin-4-amine Chemical compound C1=CC(Cl)=CC=C1NC1=CC=NC(C=2N=C(Cl)C=CC=2)=N1 VBSJJTJCXKEDDH-UHFFFAOYSA-N 0.000 claims description 6
- OFQLLYAMPFKHRN-UHFFFAOYSA-N n-(4-chlorophenyl)-6-methyl-2-pyridin-2-ylpyrimidin-4-amine Chemical compound N=1C(C=2N=CC=CC=2)=NC(C)=CC=1NC1=CC=C(Cl)C=C1 OFQLLYAMPFKHRN-UHFFFAOYSA-N 0.000 claims description 6
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
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- CHACNMTZSNLFAT-UHFFFAOYSA-N n-phenyl-2-pyridin-2-yl-6-(trifluoromethyl)pyrimidin-4-amine Chemical compound N=1C(C=2N=CC=CC=2)=NC(C(F)(F)F)=CC=1NC1=CC=CC=C1 CHACNMTZSNLFAT-UHFFFAOYSA-N 0.000 claims description 3
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82481606P | 2006-09-07 | 2006-09-07 | |
| DKPA200601151 | 2006-09-07 | ||
| PCT/EP2007/059313 WO2008028935A2 (en) | 2006-09-07 | 2007-09-06 | Pyridinyl-pyrimidine derivatives useful as potassium channel modulating agents |
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| JP2010502674A true JP2010502674A (ja) | 2010-01-28 |
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| EP (1) | EP2066655A2 (enExample) |
| JP (1) | JP2010502674A (enExample) |
| WO (1) | WO2008028935A2 (enExample) |
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| EP2114916A2 (en) * | 2007-02-02 | 2009-11-11 | NeuroSearch A/S | Pyridinyl-pyrazole derivatives and their use as potassium channel modulators |
| EP2142546B1 (en) | 2007-03-28 | 2017-06-07 | Saniona A/S | Purinyl derivatives and their use as potassium channel modulators |
| EP2885290B1 (en) | 2012-06-26 | 2017-10-18 | Saniona A/S | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| WO2017112777A1 (en) * | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| WO2017210545A1 (en) | 2016-06-02 | 2017-12-07 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| EP3571193B1 (en) | 2017-01-23 | 2021-12-01 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| KR102736865B1 (ko) | 2017-06-21 | 2024-12-03 | 샤이 테라퓨틱스 엘엘씨 | 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물 |
| MX2021004647A (es) | 2018-10-22 | 2021-08-16 | Novartis Ag | Formas cristalinas de moduladores de los canales de potasio. |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物 |
Family Cites Families (10)
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| DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| DE4029649A1 (de) * | 1990-09-19 | 1992-03-26 | Hoechst Ag | Alkoxypyridyl-pyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| JP2001089452A (ja) * | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
| EP1351691A4 (en) * | 2000-12-12 | 2005-06-22 | Cytovia Inc | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS, AND USE THEREOF |
| EP1254903B1 (en) * | 2001-04-20 | 2005-06-08 | Ciba SC Holding AG | 4-Amino-2-(pyridin-2-yl)pyrimidine as microbicidal active substances |
| TW200637556A (en) * | 2005-01-31 | 2006-11-01 | Basf Ag | Substituted 5-phenyl pyrimidines I in therapy |
| NZ556248A (en) * | 2005-03-14 | 2010-06-25 | Neurosearch As | Pyrazolyl-quinazoline potassium channel modulating agents and their medical use |
| US20090036475A1 (en) * | 2005-03-22 | 2009-02-05 | Neurosearch A/S | Pyrazolyl-Pyrimidines as Potassium Channel Modulating Agents and Their Medical Use |
| WO2007071632A2 (en) * | 2005-12-20 | 2007-06-28 | Neurosearch A/S | 2-pyridin-2-yl-quinazoline derivatives as potassium channel modulating agents for the treatment of respiratory diseases |
| JP2010505794A (ja) * | 2006-10-03 | 2010-02-25 | ノイロサーチ アクティーゼルスカブ | カリウムチャネル調節剤として有用なインダゾリル誘導体 |
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- 2007-09-06 US US12/377,392 patent/US20110144140A1/en not_active Abandoned
- 2007-09-06 WO PCT/EP2007/059313 patent/WO2008028935A2/en not_active Ceased
- 2007-09-06 JP JP2009527140A patent/JP2010502674A/ja not_active Abandoned
- 2007-09-06 EP EP07803273A patent/EP2066655A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2066655A2 (en) | 2009-06-10 |
| WO2008028935A3 (en) | 2008-05-08 |
| US20110144140A1 (en) | 2011-06-16 |
| WO2008028935A2 (en) | 2008-03-13 |
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