JP2010500387A - 結晶形態のエポチロンｂおよび医薬組成物における使用 - Google Patents

結晶形態のエポチロンｂおよび医薬組成物における使用 Download PDF

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Publication number
JP2010500387A
JP2010500387A JP2009524113A JP2009524113A JP2010500387A JP 2010500387 A JP2010500387 A JP 2010500387A JP 2009524113 A JP2009524113 A JP 2009524113A JP 2009524113 A JP2009524113 A JP 2009524113A JP 2010500387 A JP2010500387 A JP 2010500387A
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JP
Japan
Prior art keywords
epothilone
crystalline form
treatment
infusion
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009524113A
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English (en)
Japanese (ja)
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JP2010500387A5 (enExample
Inventor
エルンスト・キュステルス
ミヒャエル・ムッツ
フランク・シュトヴァッサー
Original Assignee
ノバルティス アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JP2010500387A publication Critical patent/JP2010500387A/ja
Publication of JP2010500387A5 publication Critical patent/JP2010500387A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009524113A 2006-08-16 2007-08-14 結晶形態のエポチロンｂおよび医薬組成物における使用 Pending JP2010500387A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119043 2006-08-16
PCT/EP2007/007173 WO2008019820A2 (en) 2006-08-16 2007-08-14 Crystal form of epothilone b and use in pharmaceutical compositions

Publications (2)

Publication Number Publication Date
JP2010500387A true JP2010500387A (ja) 2010-01-07
JP2010500387A5 JP2010500387A5 (enExample) 2010-09-30

Family

ID=37685905

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009524113A Pending JP2010500387A (ja) 2006-08-16 2007-08-14 結晶形態のエポチロンｂおよび医薬組成物における使用

Country Status (22)

Country Link
US (1) US8178566B2 (enExample)
EP (1) EP2064216A2 (enExample)
JP (1) JP2010500387A (enExample)
KR (1) KR20090038902A (enExample)
CN (1) CN101506217B (enExample)
AR (1) AR062375A1 (enExample)
AU (1) AU2007286454A1 (enExample)
BR (1) BRPI0715963A2 (enExample)
CA (1) CA2658475A1 (enExample)
CL (1) CL2007002362A1 (enExample)
IL (1) IL196558A0 (enExample)
MA (1) MA30656B1 (enExample)
MX (1) MX2009001635A (enExample)
MY (1) MY148355A (enExample)
NO (1) NO20091081L (enExample)
NZ (1) NZ574194A (enExample)
PE (1) PE20081317A1 (enExample)
RU (1) RU2009109352A (enExample)
TN (1) TN2009000044A1 (enExample)
TW (1) TW200815455A (enExample)
WO (1) WO2008019820A2 (enExample)
ZA (1) ZA200900227B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011146638A1 (en) 2010-05-18 2011-11-24 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
CN103910742B (zh) * 2013-01-07 2016-07-13 浙江海正药业股份有限公司 一种制备埃博霉素b无定形粉末的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504346A (ja) * 1998-02-19 2002-02-12 ノバルティス アクチエンゲゼルシャフト 細胞増殖抑制剤の発酵生産方法及びそれらの結晶体
JP2004506638A (ja) * 2000-08-16 2004-03-04 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンアナログの多形
JP2006500031A (ja) * 2002-09-23 2006-01-05 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンｂの製造、単離および精製方法並びにエポチロンｂのｘ線結晶構造

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1052974B1 (en) 1998-02-05 2009-05-20 Novartis AG Pharmaceutical formulation containing epothilone
GB0029895D0 (en) 2000-12-07 2001-01-24 Novartis Ag Organic compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504346A (ja) * 1998-02-19 2002-02-12 ノバルティス アクチエンゲゼルシャフト 細胞増殖抑制剤の発酵生産方法及びそれらの結晶体
JP2004506638A (ja) * 2000-08-16 2004-03-04 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンアナログの多形
JP2006500031A (ja) * 2002-09-23 2006-01-05 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンｂの製造、単離および精製方法並びにエポチロンｂのｘ線結晶構造

Also Published As

Publication number Publication date
CL2007002362A1 (es) 2008-08-08
AU2007286454A1 (en) 2008-02-21
MY148355A (en) 2013-03-29
CN101506217B (zh) 2012-09-05
WO2008019820A3 (en) 2008-04-17
IL196558A0 (en) 2009-11-18
TN2009000044A1 (en) 2010-08-19
US8178566B2 (en) 2012-05-15
WO2008019820A2 (en) 2008-02-21
NO20091081L (no) 2009-03-16
AR062375A1 (es) 2008-11-05
BRPI0715963A2 (pt) 2013-08-06
KR20090038902A (ko) 2009-04-21
CN101506217A (zh) 2009-08-12
NZ574194A (en) 2011-12-22
PE20081317A1 (es) 2008-10-28
TW200815455A (en) 2008-04-01
MA30656B1 (fr) 2009-08-03
CA2658475A1 (en) 2008-02-21
RU2009109352A (ru) 2010-09-27
US20100160393A1 (en) 2010-06-24
EP2064216A2 (en) 2009-06-03
ZA200900227B (en) 2009-12-30
MX2009001635A (es) 2009-02-23

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