JP2010280612A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for oral cavities, used for applicator integration type containers, which can simply and stably be supplied to the coating portions of the applicator integration type containers in effective amounts at every time and contains a cationic anti-microbial agent. <P>SOLUTION: This composition for oral cavities, used for applicator integration type containers, containing a cationic anti-microbial agent, includes (I) the following (A) to (C): (A) 0.05 to 0.5 mass% of a cationic anti-microbial agent, (B) 0.05 to 2.5 mass% of at least one nonionic thickener selected from the group consisting of hydroxyethylcellulose, hydroxypropylmethylcellulose and methylcellulose, and (C) ≥50 mass% of water, and has (II) a viscosity of 500 to 15,000 mPa s at a shear speed of 8 s<SP>-1</SP>. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an oral composition for use in an applicator-integrated container.

  An applicator-integrated container is used in order to apply a drug to an affected site more efficiently and to clean the site. The container includes a storage unit for storing the drug, an application unit for applying the drug to the affected site, and a transport unit for transporting the drug from the storage unit to the application unit, if necessary. Is provided.

  When the affected part is in the oral cavity, it is necessary to put the application part of the container into the oral cavity. Then, in order to easily reach the affected part to the affected part, the application part is of a size that can be put into the oral cavity, and a shape in which an elongated cylindrical (rod-like) member is connected to the application part. It is preferable to have it. Further, the storage unit is required to have a capacity capable of storing an appropriate amount of the oral composition.

  The oral composition for use in such an applicator-integrated container for oral diseases is required to have appropriate physical properties according to the container. That is, it is preferable that the oral composition is an appropriate amount that is ejected from the application part with an appropriate pressure. Moreover, it is preferable that the said composition for oral cavity does not have a discharge delay. Furthermore, it is preferable that the composition for oral cavity does not cause clogging at the application part, the delivery path part and the like.

  As an oral composition for use in an applicator-integrated container for oral cavity, for example, Patent Document 1 describes an oral composition for use in a toothbrush provided with a built-in type container for accommodating a composition. Patent Document 2 describes a liquid dentifrice composition for use in a small amount using an electric toothbrush.

  However, the composition for oral cavity containing the active ingredient applied to an oral disease part for using for an applicator integrated container for oral cavity has not been developed until now.

  In order to efficiently and practically use the applicator-integrated container for oral use, it is preferable that an effective amount of the oral composition is supplied from the application unit every time, and thus the container is pre-filled ( That is, the properties of the composition to be prefilled are important. In particular, it is important that the composition is such that an effective amount is discharged by appropriate pressing, the discharge delay is small, and the coating part and the feeding part are not clogged.

International Publication No. 04/032674 International Publication No. 04/032889

  The present invention provides an oral composition containing a cationic bactericidal agent that can be easily and stably supplied to the application part of the applicator-integrated container each time for use in the applicator-integrated container. The task is to do.

  Surprisingly, the inventors have selected a thickener and controlled the viscosity at a predetermined shear rate, so that an effective amount is discharged from the applicator-integrated container with a constant pressure, and the discharge delay is reduced. The present inventors have found that an oral composition that is less clogged and can be provided can be provided, and have been further improved to complete the present invention.

  That is, this invention relates to the composition for oral cavity of the following items 1-5.

Item 1.
An oral composition containing a cationic disinfectant for use in an applicator-integrated container,
(I) contains (A) to (C) below,
(A) 0.05 to 0.5% by mass of a cationic fungicide
(B) 0.05 to 2.5% by mass of at least one nonionic thickener selected from the group consisting of hydroxyethylcellulose, hydroxypropylmethylcellulose and methylcellulose
(C) 50% by mass or more of water (II) having a viscosity of 500 to 15000 mPa · s at a shear rate of 8 s ⁻¹ ,
Oral composition.
Item 2.
Item 2. The oral composition according to Item 1, wherein the cationic fungicide is a quaternary ammonium salt and / or a biguanide fungicide.
Item 3.
Item 3. The oral composition according to Item 1 or 2, further containing 5 to 15% by mass of glycerin.
Item 4.
Item 4. The oral cavity composition according to any one of Items 1 to 3, wherein the applicator application part of the applicator-integrated container is in the form of a brush.
Item 5.
The applicator-integrated container includes an application unit, a delivery path unit, a storage unit, and a delivery mechanism adjacent to the storage unit,
The composition for oral cavity is transported from the storage container to the application unit through the transmission path unit.
Item 5. An oral composition for use in an applicator-integrated container according to any one of Items 1 to 4.

  The oral composition for use in the applicator-integrated container of the present invention is effective every time without being clogged with the application part or the feeding part of the container even if it is repeatedly used in the applicator-integrated container. Can be easily and stably supplied to the application part of the container.

The external appearance schematic of the container for a discharge test which is one aspect | mode of an applicator integrated container is shown. The cross-sectional schematic of the container for discharge tests which is one aspect | mode of an applicator integrated container is shown.

  Hereinafter, the present invention will be described in more detail.

  The composition for oral cavity of the present invention is for use in an applicator integrated container. When the composition for oral cavity is used for an applicator-integrated container, clogging does not occur, and an effective amount is simply and stably supplied each time.

  The composition for oral cavity of the present invention contains a cationic fungicide. The cationic disinfectant contained in the oral composition of the present invention is not particularly limited, but quaternary ammonium salts and biguanide disinfectants are preferable, for example, cetylpyridinium chloride (CPC), benzethonium chloride, distearyldimethylammonium chloride. , Quaternary ammonium salts such as stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, lauryltrimethylammonium chloride, laurylpyridinium chloride, chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine gluconate, alexidine hydrochloride, alexidine acetate, Cationic fungicides such as biguanide fungicides such as alexidine gluconate are included. Of these, cetylpyridinium chloride, chlorhexidine hydrochloride, benzethonium chloride, and chlorhexidine gluconate are preferable, and cetylpyridinium chloride, chlorhexidine hydrochloride, and chlorhexidine gluconate are particularly preferable. In addition, these cationic bactericides can be used 1 type or in combination of 2 or more types.

  The blending amount of the cationic bactericidal agent is preferably 0.05 to 0.5% by mass, more preferably 0.1 to 0.5% by mass, and still more preferably 0.1 to 0.5% by mass with respect to the total amount of the oral composition. 0.4 mass%, particularly preferably 0.1 to 0.3 mass%.

  Moreover, the composition for oral cavity of this invention contains a thickener. Among the thickeners, nonionic thickeners are preferable. Nonionic properties have little effect on cationic fungicides. An appropriate viscosity can be imparted to the composition by the thickener. Specifically, at least one selected from the group consisting of hydroxyethylcellulose (HEC), hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) is used as the nonionic thickener in the oral composition of the present invention. Of these, hydroxyethyl cellulose is particularly preferred.

  Nonionic thickeners other than these may be used, but when used in an applicator-integrated container, a delay in supply to the application unit occurs, or compatibility with the cationic disinfectant deteriorates. It is preferable to use those described above.

  As a compounding quantity of a nonionic thickener, Preferably it is 0.05-2.5 mass% with respect to oral composition whole quantity, More preferably, it is 1-2 mass%. Particularly when hydroxyethyl cellulose is used, it is more preferably 1 to 1.5% by mass, and still more preferably 1 to 1.2% by mass.

  The oral composition of the present invention may be in any form such as a gel preparation or an emulsion preparation, but is preferably a gel preparation.

  Moreover, what is generally added to the composition for oral cavity can also be mix | blended with the composition for oral cavity of this invention other than said thing.

  For example, a nonionic surfactant or an amphoteric surfactant can be blended as the surfactant. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters, fatty acid alkanolamides, sorbitan fatty acid esters, fatty acid monoglycerides, and polyoxyethylene addition coefficients of 8 to 10. A polyoxyethylene alkyl ether group having 13 to 15 carbon atoms in the alkyl group or a polyoxyethylene alkyl phenyl ether having a polyoxyethylene addition coefficient of 10 to 18 and 9 carbon atoms in the alkyl group, diethyl sebacate, poly Examples thereof include oxyethylene hydrogenated castor oil and fatty acid polyoxyethylene sorbitan. Examples of zwitterionic surfactants include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1hydroxyethylimidazoline betaine sodium. It is done. These surfactants can be blended alone or in combination of two or more. The compounding quantity is 0.1-5 mass% normally with respect to the composition whole quantity.

  As a flavoring agent, menthol, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, osimene, n-decyl alcohol, citronell, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, ethyl linalool , Thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, Perfumes such as fennel oil, cinnamon oil, cinnamaldehyde, mint oil, and vanillin can be blended in an amount of 0.01 to 1% by mass based on the total amount of the composition alone or in combination of two or more.

  In addition, sweeteners such as sodium saccharin, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, thaumatin, asparatylphenylalanyl methyl ester, p-methoxycinnamic aldehyde, etc. are added to the total amount of the composition. 0.01-1 mass% can be mix | blended.

  Furthermore, as a wetting agent, sorbit, ethylene glycol, propylene glycol, 1,3-butylene glycol, polypropylene glycol, xylite, maltite, lactit, polyoxyethylene glycol, and the like can be used alone or in combination of two or more.

  The oral composition of the present invention has amphoteric properties such as vitamin E such as dl-α-tocopherol acetate, tocopherol succinate, or tocopherol nicotinate, and dodecyldiaminoethylglycine as a medicinal component other than the cationic fungicide. Bactericides, nonionic fungicides such as triclosan and isopropylmethylphenol, enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (lytechenzyme), sodium monofluorophosphate, potassium monofluorophosphate, etc. Alkali metal monofluorophosphate, fluorides such as sodium fluoride and stannous fluoride, tranexamic acid and epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyl Chin acid, glycerophosphate, chlorophyll, sodium chloride, Karopeputaido, dipotassium glycyrrhizinate, allantoin, carbazochrome, hinokitiol, etc., may be blended alone or in combination of two or more.

  The composition for oral cavity of the present invention contains 50% by mass or more, preferably 70% by mass or more, and more preferably 80% by mass or more. Further, glycerin is preferably added as a wetting agent to the oral composition of the present invention, and the blending amount is 5 to 15% by mass, preferably 5 to 10% by mass, based on the total amount of the oral composition. . In addition, by mix | blending glycerol, a composition becomes difficult to cause clogging and a taste is also improved.

Furthermore, since the composition for oral cavity of this invention is for using for an applicator integrated container, what has an appropriate viscosity is preferable. Specifically, 500~15000mPa · s at room temperature (25 ° C.) Oite shear rate ^{8s -1,} preferably 500~10000mPa · s, more preferably 550~5800mPa · s. The viscosity can be measured with a Brookfield viscometer.

  The present invention provides a method for producing an oral composition containing a cationic fungicide for use in an applicator-integrated container, which contains a cationic fungicide, a nonionic thickener, and water, using the viscosity as an index. Also provide. In addition, about the kind and content of a preferable cationic disinfectant and a nonionic thickener, and content of water are as above-mentioned.

  The applicator-integrated container for filling the oral composition of the present invention comprises a storage part for filling and storing the oral composition and an application part for applying the oral composition to the oral disease part. is there. Moreover, the said storage part and application | coating part are connected as needed, and the transmission path part for transporting a composition for oral cavity is provided. In the container, the storage unit may be detachable and can be repeatedly filled, or may be put on the market and disposed in a prefilled (prefilled) state.

  It is preferable that the said application part is a magnitude | size suitable for applying in an intraoral area. Moreover, the application part may be the outlet itself of the feeding part, or a brush (for example, a brush like a toothbrush or interdental brush in which one or two or more hair bundles are planted), brush, brush, or sponge. Such a form that the composition can be easily applied is not particularly limited.

  Moreover, the said storage part has a larger thing in order to increase the amount of composition for oral cavity which can be stored. However, when the applicator-integrated container is used by being held in a hand, it is preferable to set the size of the storage portion so that the container can be grasped by the hand. Specifically, for example, when the storage part is cylindrical, a volume of 3 to 15 mL and a length of about 30 to 80 mm are preferable.

  Moreover, the said applicator integrated container may be provided with the sending path part which connects an application part and a storage part, and conveys an oral composition. When an oral applicator integrated container is used, it is necessary to make the application part reach the back of the oral cavity. Therefore, it is preferable that the feeding path is a thin tubular shape. However, if the shape is too thin, it is not suitable for transporting the composition from the storage part to the application part. In addition, if the shape is too thick, a lot of the composition will remain in the feeding section after use, which is not preferable from the viewpoint of securing an effective use amount, and is difficult to apply to the oral cavity due to its thickness. . A person skilled in the art can set an appropriate feed section in consideration of such a situation. For example, the length is preferably 40 to 80 mm and the volume is preferably 0.025 to 0.2 ml.

  If a storage part and a channel part are set in the above ranges, the bottom area of the storage part and the cross-sectional area of the channel part will be significantly different. For example, when the container is cylindrical, (the bottom area of the storage container: the cross-sectional area of the tubular path) is (1000: 5 or more) while satisfying the requirements of the storage part and the sending part. Is preferable, (1000: 5 to 50) is more preferable, (1000: 5 to 20) is more preferable, and (1000: 10 to 15) is still more preferable.

  When the cross-sectional area of the channel part is smaller than the bottom area of the storage part, when the oral composition is delivered from the storage part to the channel part, the transport speed of the oral composition increases rapidly. Therefore, it is difficult to supply a stable amount each time to the application unit via the transmission path unit.

  For this reason, it is preferable that the applicator-integrated container according to the present invention includes a delivery mechanism capable of delivering the oral composition in the storage unit to the application unit through a certain amount of the delivery path unit. In particular, it is preferable to be provided adjacent to the storage unit.

  Such a delivery mechanism is not particularly limited, and a known one can be appropriately selected and used. For example, as described in Patent Document 1 (International Publication No. 04/032674), an electrically operated pumping system or a mechanism for realizing manual pumping can be used. Further, as disclosed in JP-A-2007-319392, the rotating body located in a part of the container is rotated in one direction to press the composition stored in the storage unit so that the composition is discharged outward from the discharge port. A mechanism that allows extrusion is preferred. In a preferred embodiment, an intermediate dish such as a piston body is provided in contact with the storage unit, the rotating body provided at the end of the applicator-integrated container and the intermediate dish are connected, and the rotating body is arranged in one direction. By rotating, the inner dish presses the storage part, and the composition in the storage part is supplied to the application part through the feeding path part.

  The composition for oral cavity according to the present invention described above is particularly suitable for being prefilled in such an applicator-integrated container. If it is the said composition for oral cavity, when it sends out from the storage part of the said applicator integrated container to a sending part, a transport speed will increase rapidly, but the supply amount to an application part will be stabilized. Moreover, even if it supplies to an application part repeatedly over a long period of time, it will not cause clogging in an application part or a sending way part. Further, a stable amount is supplied to the application unit by each delivery mechanism.

  For example, when the application part is in the form of a brush, there is an outlet of the passage part at the base part of the brush, and the oral composition is discharged from the outlet to the application part in the brush form. Supplied. And the composition for oral cavity can be apply | coated to an oral disease site | part with the said brush.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples.

Examination of optimum viscosity <Preparation of oral composition>
Various thickeners (sodium alginate (NaArg), xanthan gum, and hydroxyethylcellulose (HEC)) were dispersed in glycerin, and this was added to distilled water with stirring and stirred vigorously for 1 hour. After stirring, the mixture was allowed to stand overnight at room temperature to prepare various oral compositions.

  In addition, 10 mass% of glycerol was mix | blended in the said composition. The thickener was blended in such an amount that the final concentration after preparation of the composition was the value (mass%) shown in Table 1.

The thickener used is shown below.

Hydroxyethyl cellulose: Fuji Chemi HEC CF-Y (Sumitomo Seika Co., Ltd.)
Methylcellulose: METALOSE SM-4000 (Shin-Etsu Chemical Co., Ltd.)
Hydroxypropyl methylcellulose: METALOSE 60SH-4000 (Shin-Etsu Chemical Co., Ltd.)
Hydroxypropyl cellulose: HPC H (Nippon Soda Co., Ltd.)
Pullulan: Pullulan (Hayashibara Biochemical Research Institute)
Polyvinyl alcohol: Gohsenol EG-30 (Nippon Synthetic Chemical Industry Co., Ltd.)
Xanthan gum: Keldent (CP Kelco)
Sodium alginate: Duck Algin NSPH (Kibun Food Chemifa Co., Ltd.)

<Discharge test container>
A cylindrical passage having an inner diameter of 14 mm and a length of 50 mm is connected to a cylindrical passage having an inner diameter of 1 mm and a length of 60 mm, and the storage container is incorporated with a delivery mechanism disclosed in the drawings of JP-A-2007-319392. A composition discharge test container was obtained. That is, the discharge test container is an embodiment of an applicator-integrated container, and includes a grip portion and a feeding path portion. Inside the grip portion, a piston pan is provided in contact with the storage portion. A mechanism for moving the inside of the grip portion like a piston is connected to the plate from a rotating body provided at the end of the grip portion. By rotating the rotating body in one direction, the inner tray presses the storage unit, and the composition in the storage unit is discharged from the end of the transmission unit through the transmission unit. A schematic external view of the discharge test container is shown in FIG. 1a, and a schematic cross-sectional view is shown in FIG. 1b.

  The storage container was filled with various prepared oral compositions described in Table 1.

<Discharge test>
In the above discharge test container, the rotating body of the delivery mechanism was rotated so that the composition was discharged at a rate of 0.03 mL / s, and the time required to discharge 0.03 mL of the composition was measured. It can be seen that the larger the measured value, the higher the after-drawing property of the composition, which is not preferable. Specifically, “○” indicates that the measurement value is less than 0.5 seconds, “△” indicates that the measurement value is 0.5 seconds or more and less than 1.0 second, and “×” indicates that the measurement value is 1.0 second or more. evaluated. The results are shown in Table 1.

<Viscosity measurement test>
Using a Brookfield viscometer HVDV-II, RVDV-II, or LVDV-II, using a cone type spindle No. 52 or 41, shear stress was applied at 25 ° C. and at a shear rate of 0.2 to 10.0 s ⁻¹ . The viscosity was measured and calculated. The results are shown in Table 1.

<CPC compatibility>
CPC (cetylpyridinium chloride) was blended in each composition so as to be 0.3% by mass in each composition. The composition after blending was visually checked for white turbidity, and the white turbidity was evaluated as “x”, and the colorless and transparent one was evaluated as “◯”. All compositions were colorless and transparent before blending CPC.

As shown in Table 1, sodium alginate and xanthan gum have poor CPC compatibility and are not preferred for use with CPC. On the other hand, HEC has good CPC compatibility and is preferred for use in the oral composition of the present invention.
On the other hand, paying attention to the composition discharge test results, the composition for oral cavity containing 1.5% by mass of sodium alginate or xanthan gum has good discharge property, and when the content is further increased, the discharge property becomes poor as it increases. It became. On the other hand, the composition for oral cavity containing 1.0 to 1.2% by mass of HEC has good ejection properties. As the content is further increased, the ejection properties become worse as the content is increased.

By the way, as shown in Table 1, since the viscosity of the composition shows greatly different values depending on the type and amount of the thickener used, the shear rate, and the like, the preferred composition for oral cavity of the present invention using the viscosity as an index. It is difficult to find things. However, from the results in Table 1, there is no discharge delay when the viscosity at a shear rate of 8 s ⁻¹ is less than about 6000 mPa · s, and a slight discharge delay occurs when the viscosity is 6000 mPa · s or more and less than 17000 mPa · s. 17000 mPa · s or more, it can be seen that a large delay occurs. From this, it was found that the preferred oral composition of the present invention can be selected using the viscosity at the shear rate of 8 s ⁻¹ as an index.

Examination of clogging Next, the composition for oral cavity shown in Table 2 was prepared as follows, and various tests and clogging were examined.

  CPC, glycerin, various thickeners, and water were stirred and mixed to prepare various oral compositions. In addition, these components used the value (mass%) of Table 2.

  These various oral compositions are filled in the same discharge test container as prepared in Study Example 1, and the oral composition is discharged from the end of the tubular portion (0.03 mL at a rate of 0.03 mL / s). Then, the oral cavity composition at the end of the tubular part was wiped off and allowed to stand at 40 ° C. for 48 hours. Then, the composition for oral cavity was discharged again (0.03 mL at a rate of 0.03 mL / s) to examine whether the end of the tubular portion was clogged. The judgment criteria were as follows.

○: 0.03 mL is discharged in the same time as the drug discharge test. Δ: It takes longer than the drug discharge test, but 0.03 mL is discharged.
X: The composition for oral cavity is not discharged.

Other examinations (discharge test, viscosity measurement, CPC compatibility examination) were performed in the same manner as described in the above “examination of optimum viscosity”.

The results are shown in Table 2.

  The prescription example of the composition for oral cavity which concerns on this invention below is shown.

Formulation Example 1
Ingredient Mass%
Cetylpyridinium chloride 0.1
Zinc chloride 1.2
Hydroxyethyl cellulose 1.1
Glycerin 15.0
Propylene glycol 3.0
Methyl paraoxybenzoate 0.1
Polyoxyethylene (60) hydrogenated castor oil 1.0
Fennel oil 0.1
Cinnamaldehyde 0.2
Timor 0.2
Water balance 100.0

When prefilled into an applicator-integrated container in which a cylindrical storage container having an inner diameter of 14 mm and a length of 50 mm was connected to a circular tubular path having an inner diameter of 1.0 m and a length of 40 mm, no discharge delay and clogging were observed. In the following (Prescription Examples 2 to 7), similarly, pre-filled and used in an applicator integrated container, no discharge delay and clogging were observed.

Formulation Example 2
Ingredient Mass%
Chlorhexidine hydrochloride 0.2
Sodium fluoride 0.2
Hydroxypropyl methylcellulose 1.0
Glycerin 12.0
Trisodium citrate 0.1
Citric acid 0.01
Saccharin sodium 0.1
Polyoxyethylene (60) hydrogenated castor oil 1.0
Ethanol 10.0
Methyl salicylate 0.1
Peppermint oil 0.2
Vanillin 0.1
Remaining water Total 100.0

Formulation Example 3
Ingredient Mass%
Chlorhexidine gluconate 0.1
Cetylpyridinium chloride 0.1
Tocopherol acetate 0.05
Pyridoxine hydrochloride 0.02
Methylcellulose 1.0
Glycerin 7.0
Trisodium citrate 0.1
Citric acid 0.01
Saccharin sodium 0.01
Palm oil fatty acid amidopropyl betaine solution 0.5
Ethanol 7.0
Clove oil 0.1
l-Menthol 0.2
Remaining water Total 100.0

Formulation Example 4
Ingredient Mass%
Cetylpyridinium chloride 0.3
Allantoin 0.5
Dipotassium glycyrrhizinate 0.4
Methylcellulose 1.3
Glycerin 5.0
Sodium citrate 0.1
Saccharin sodium 0.2
Stevia extract 0.02
Polyoxyethylene (60) hydrogenated castor oil 0.5
Ethanol 10.0
Fragrance 0.1
Remaining water Total 100.0

Formulation Example 5
Ingredient Mass%
Chlorhexidine gluconate 0.1
Sodium fluoride 0.2
Potassium nitrate 0.5
Hydroxypropyl methylcellulose 2.0
Glycerin 10.0
Propylene glycol 5.0
Saccharin sodium 0.2
Polyoxyethylene hydrogenated castor oil 0.5
l-Menthol 0.2
Fragrance 0.3
Remaining water Total 100.0

Formulation Example 6
Ingredient Mass%
Cetylpyridinium chloride 0.05
Allantoin 0.3
Hinokikiol 0.1
Dipotassium glycyrrhizinate 0.2
Methylcellulose 1.0
Glycerin 10.0
Propylene glycol 5.0
Ethanol 10.0
Saccharin sodium 0.1
Alkyl glucoside 2.0
d-Camphor 0.1
Fragrance 0.1
Remaining water Total 100.0

Formulation Example 7
Ingredient Mass%
Chlorhexidine hydrochloride 0.3
Allantoin 0.3
Lysozyme chloride 0.05
Hydroxypropyl methylcellulose 0.5
Methylcellulose 0.7
Glycerin 5.0
Propylene glycol 5.0
Sorbit solution 10.0
Ethanol 10.0
Saccharin sodium 0.2
l-Menthol 0.1
Remaining water Total 100.0

1: Application unit 2: Feeding unit 3: Storage unit 4: Delivery mechanism

Claims (4)

An oral composition containing a cationic disinfectant for use in an applicator-integrated container,
(I) contains (A) to (C) below,
(A) 0.05 to 0.5% by mass of a cationic fungicide
(B) 0.05 to 2.5% by mass of at least one nonionic thickener selected from the group consisting of hydroxyethylcellulose, hydroxypropylmethylcellulose and methylcellulose
(C) 50% by mass or more of water (II) having a viscosity of 500 to 15000 mPa · s at a shear rate of 8 s ⁻¹ ,
Oral composition. The composition for oral cavity of Claim 1 whose cationic disinfectant is a quaternary ammonium salt and / or a biguanide type disinfectant. Furthermore, the composition for oral cavity of Claim 1 or 2 which contains 5-15 mass% of glycerol. The composition for oral cavity in any one of Claims 1-3 whose applicator application part of an applicator integrated container is a brush form.

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