JP2010195746A - Glutathione production promoter and skin care preparation and cosmetic using the glutathione production promotor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new glutathione production promotor which promotes the glutathione production by the living body itself and persistently improves physiological functions in the living body. <P>SOLUTION: The glutathione production promotor includes an extract from Rosa centifolia Linne, genus Rosa, Rosaceae family as the effective component. The glutathione production promotor acts, upon uptake into the living body, directly on the glutathione production pathway in the living body to promote glutathione production and exhibits such actions as 1. energy metabolism promotion, 2. anti-oxidation, 3. detoxification, 4. anti-allergy, and 5. anti-pigmentation. Since the effective component is naturally originated, the glutathione production promotor is highly safe and may continuously be used for long time, and, therefore, may suitably be used for external preparations for the skin and cosmetics. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a glutathione production promoter. More specifically, the present invention relates to a glutathione production promoter using a rose extract as an active ingredient, and a skin external preparation and a cosmetic using the glutathione production promoter. In addition, in this invention, cosmetics are the concept containing medicinal cosmetics (quasi-drug).

  Glutathione is a peptide thiol that is widely distributed in the living body, and is a tripeptide composed of glutamic acid, cysteine, and glycine, also known as γ-L-glutamyl-L-cysteinyl-glycine. Glutathione is distributed in all organs in the living body, and is particularly contained in a large amount in the liver, spleen, adrenal gland, erythrocytes and the like.

  Glutathione has been shown to perform various functions in vivo. For example, glutathione is involved in the oxidation-reduction reaction system of living body through nicotinamide adenine dinucleotide phosphate (NADP) and nicotinamide adenine dinucleotide (NAD). Contribute to. Further, glutathione has a thiol group (SH group) in its molecule, and thus has a function of protecting the living body from oxidative damage exerted on the living body by being oxidized by itself.

  Furthermore, glutathione enhances the enzyme activity involved in various conjugated detoxification reactions in the living body and exhibits an excellent detoxification action. In addition, glutathione has a function of improving disturbance of acetylcholine-cholinesterase balance, which is a factor of allergy occurrence, and is also known to have an antiallergic effect. Further, it has been reported that administration of a glutathione preparation has improved pigmentation (Non-patent Document 1).

  Thus, glutathione is an important substance that exhibits various functions in vivo, and in recent years, a technique for promoting glutathione production in vivo has been developed. For example, Patent Document 1 discloses that crocetin has a glutathione production promoting effect. Patent Document 2 discloses that each of γ-tocopherol and δ-tocopherol has a glutathione production promoting action, and this action is more remarkable than α-tocopherol having the highest physiological activity.

  Here, the roses related to the present invention will be described below. The rose (Rosa centifolia Linne) is a deciduous or semi-evergreen broad-leaved shrub that has a height of about 1-2 m in the Rosaceae family. The roses have various colors and shapes, such as spring, two seasons, and four seasons, and generally have an aroma.

  The roses, for example, have effects such as regulating hormone secretion (improving menstrual pain and premenstrual syndrome (PMS)), tonic effects on the circulatory system, digestive system, and nervous system, improving coldness, and antidepressant action. I know that there is.

  The roses are also expected to have various effects on the skin. For example, Patent Document 3 proposes a technique in which Western rose promotes the expression of E-cadherin in human skin, thereby improving and strengthening adhesion between skin epidermal cells and improving skin wrinkles, sagging, and texture structure. ing. Patent Document 4 proposes a technique that prevents the loss of hyaluronic acid in the stratum corneum by inhibiting the activity of hyaluronidase from rose rose, maintaining the moisturizing ability of the stratum corneum, and maintaining the transparency of the skin. Patent Document 5 proposes a skin whitening external preparation characterized by containing rose or a solvent extract thereof as an active ingredient.

JP 2008-0747421 A JP 2007-284430 A JP 2004-359632 A JP 2003-012489 A JP 2002-029959 A

Shinkin 21 vol.7 Jun 1967 725-729

  As described above, glutathione is effectively used for in vivo energy metabolism, antioxidant, antiallergic, pigmentation prevention and the like. For example, when a living body is exposed to an oxidizing environment, glutathione in the living body is consumed and depleted, normal cell functions cannot be maintained, and physiological functions in the living body are degraded. In order to improve various physiological functions in the living body, attempts have been made to administer various substances that improve the corresponding physiological function in the living body. However, the method of administering various substances necessary for maintaining physiological functions can be expected only for a temporary effect, and does not lead to a fundamental solution.

  Therefore, the main object of the present invention is to provide a novel technique that promotes the production of glutathione in the living body and continuously improves the physiological function in the living body.

  As a result of searching for an effective substance that promotes the production of glutathione, the present inventors have succeeded in specifically confirming that the rose extract has an effect of promoting the production of glutathione by paying attention to the extract of rose. As a result, the present invention has been completed.

That is, the present invention first provides a glutathione production promoter comprising, as an active ingredient, a rose extract extracted from the Rosaceae rose genus Rosa centifolia Linne. The glutathione production promoter according to the present invention promotes glutathione production by directly acting on the glutathione production pathway in the living body, and in vivo energy metabolism ability, antioxidant ability, detoxification action, antiallergic action, prevention of pigmentation Improve the action.
The rose extract that can be used as an active ingredient in the glutathione production promoter according to the present invention can be extracted from any part of the rose, but in the present invention, an extract obtained from a flower is used. Is preferred.

  The glutathione production promoter according to the present invention can be suitably used for external preparations for skin and cosmetics to which pharmacologically acceptable additives are added.

  Unlike the conventional coping therapy, the glutathione production promoter according to the present invention acts directly on the glutathione production pathway in the living body to promote glutathione production, and thus fundamentally improves the physiological function in the living body. Is possible.

In an Example, it is a drawing substitute graph which shows the measurement result of glutathione production amount.

  Hereinafter, preferred embodiments for carrying out the present invention will be described. In addition, embodiment described below shows an example of typical embodiment of this invention, and, thereby, the range of this invention is not interpreted narrowly.

<Glutathione production promoter>
The glutathione production promoter according to the present invention comprises a rose extract as an active ingredient. The rose extract contained in the glutathione production promoter according to the present invention is taken into the living body, thereby directly acting on the glutathione production pathway in the living body to promote glutathione production. By promoting glutathione production in vivo, the following effects can be obtained.

1. Promotion of energy metabolism Glutathione participates in the oxidation-reduction anti-system of the living body through NADP, NAD, etc. in the living body and contributes to energy production. As a result, effects such as activation of functions such as cell proliferation, metabolism, repair, and anti-aging can be expected.

2. Antioxidant Since glutathione has a thiol group (SH group) in its molecule, it is oxidized by itself to protect the living body from oxidative damage exerted on the living body. As a result, it can be expected to prevent all diseases and aging caused by oxidative damage.

3. Detoxification Glutathione enhances the enzyme activity involved in various conjugated detoxification reactions in vivo and has an excellent detoxification action. As a result, it can be expected to prevent various diseases caused by foreign body intrusion that adversely affects the living body and improve the metabolism of the drug.

4. Antiallergy Glutathione has a function of improving disturbance of acetylcholine-cholinesterase balance, which is a factor of allergy, and has an antiallergic effect. As a result, an effect of preventing various diseases caused by allergy (for example, urticaria, atopic dermatitis, contact dermatitis, allergic rhinitis, hay fever, asthma, etc.) can be expected.

5. Prevention of pigmentation Glutathione has the function of preventing skin pigmentation. Therefore, when the glutathione production promoter according to the present invention is used in an external preparation for skin and cosmetics described later, it can be expected to have effects on prevention and improvement of pigmentation due to side effects of the medicine, prevention and improvement of stains and freckles, etc. .

  In the present invention, the rose extract refers to an extract obtained by extracting flowers, rhizomes, stems, leaves, etc. with a suitable solvent, Rosaceae rose genus Rosa centifolia Linne, Usually used as a concentrated solution of the extracted solvent. In addition, a freeze-dried solution of the concentrated solution can be used for the glutathione production promoter according to the present invention.

  The specific site | part of the rose which is used for extraction is not specifically limited unless the objective of this invention is impaired, All sites, such as a flower, a rhizome, a stem, a leaf, can be selected freely and can be used. It is also possible to perform extraction using a dried product obtained by pouring each part through hot water. In the present invention, it is particularly preferable to use a dried product obtained by drying a rose flower in an appropriate size.

  The solvent used for the extraction is not particularly limited, and usually one or two or more solvents that can be used for plant extraction can be freely selected and used. Examples thereof include water, alcohols, glycols, ketones, esters, ethers, and halogenated carbons. Examples of alcohols include ethanol, methanol, and propanol. Examples of glycols include ethylene glycol, diethylene glycol, butylene glycol, and propylene glycol. Examples of ketones include acetone and methyl ethyl ketone. Examples of the esters include ethyl acetate, propyl acetate, and ethyl formate. These solvents may be used alone or as an aqueous solution, and may be used as any two or three or more mixed solvents. Among these, in the present invention, a hydrophilic solvent is preferable, and it is particularly preferable to use water, ethanol, or butylene glycol alone or in combination. This is because these solvents have high cytotoxicity because of low cytotoxicity, and the obtained extract can be lyophilized for use.

  The extraction method is not particularly limited, and a normal extraction method can be freely selected and used. For example, a method of filtering an arbitrary portion of rose rose in the solvent for 24 hours and a method of filtering after extraction while heating, stirring or the like at a temperature lower than the boiling point of the solvent, and the like can be mentioned.

  Although the extracted rose extract can be used as it is as an active ingredient of the glutathione production promoter according to the present invention, the extract is further used in an appropriate separation means (for example, partition extraction, gel filtration, silica gel chromatography). It is also possible to fractionate and use a fraction with high activity by a method, reverse phase or normal phase high performance liquid chromatography).

<External preparation for skin>
The glutathione production promoter according to the present invention can be suitably used for an external preparation for skin utilizing its excellent glutathione production promotion effect. Since the external preparation for skin according to the present invention contains an extract of rose rose, it is directly taken into the glutathione production pathway in the living body by being taken into the living body from the skin and promotes the production of glutathione as described above. In addition, 1. It promotes energy metabolism, 2. Antioxidation, 3. Detoxification, 4. Antiallergy, 5. Prevention of pigmentation. Therefore, it can be expected to be effective in, for example, promoting wound repair, pressure sores, burns, urticaria, atopic dermatitis, contact dermatitis, eczema, pruritus due to side effects of drugs, and the like.

  The external preparation for skin according to the present invention can be applied to external preparations of any dosage form. For example, it can be applied to external preparations such as external preparations, external preparations, creams, ointments, sprays, nasal drops, liniments, lotions, haps, plasters, sprays, aerosols, etc. .

  One or more pharmacologically acceptable additives can be freely selected and contained in the skin external preparation according to the present invention. For example, bases, surfactants, preservatives, emulsifiers, colorants, flavoring agents, fragrances, stabilizers, preservatives, antioxidants, lubricants, solubilizers, suspending agents, oils, thickeners All additives that can be usually used in the field of pharmaceutical preparations, such as chelating agents, enzymes, and pH adjusting agents can be contained.

  In addition, the glutathione production promoter according to the present invention has a low necessity for careful use in combination with multiple drugs because the active ingredient is a naturally-derived component. Therefore, any existing drug or medicinal component can be freely selected as a mixture by selecting one or more kinds freely. For example, antioxidants, anti-inflammatory agents, cell activators, UV inhibitors, moisturizers, blood circulation promoters, antibacterial agents, analgesics, steroids, antifungal agents, antitussives, antihistamines, vitamins, antitumor agents, etc. Any drug can be formulated.

  Among these drugs and medicinal components, typical ones are specifically exemplified below. Here, the “derivative” is a concept including a formable ester or salt. Moreover, since the same component may have a some medicinal effect, in that case, the same name is described to a some medicine and medicinal component. In the case of plants, the names of other herbal medicines are also listed in parentheses.

  Examples of antioxidants include vitamin E and its derivatives, vitamin C and its derivatives, carotenoids, dibutylhydroxytoluene, butylhydroxyanisole, rutin and its derivatives, glutathione and its derivatives, superoxide dismutase, mannitol, caquette extract, Genokosho extract, Hawthorn extract, Peonies extract, Ginkgo biloba extract, Koganebana extract , Rosemary (mannenrou) extract, tea extract (Oolong tea, black tea, green tea, etc.).

  Examples of the anti-inflammatory agent include glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid and derivatives thereof, sulfur and derivatives thereof, aloe extract, ashitaba extract, nettle extract, Inchinkou (Kawaragimugi) extract, turmeric extract, yellowfin ( (Owaku) extract, Hypericum extract, Chamomile extract, Comfrey extract, Honeysuckle extract, Watercress extract, Salvia extract, Salamander extract, Perilla extract, Examples include birch extract, elderberry extract, catfish extract, mugwort extract, eucalyptus extract, mugwort extract, forsythia extract, kumazasa extract, zinc oxide and the like.

  Examples of cell activators include vitamin A and its derivatives, asparagus extract, soybean extract, jujube extract, garlic extract, carrot extract, beech extract, royal jelly, yeast extract, microbial fermentation Examples include metabolites and ganoderma extract.

  Examples of UV inhibitors include paramethoxycinnamate-2-ethylhexyl, 4-tert-butyl-4′-methoxydibenzoylmethane, oxybenzone and derivatives thereof, titanium oxide, fine particle titanium oxide, zinc oxide and fine particle zinc oxide. Etc. When inorganic powders such as titanium oxide and zinc oxide are fine particles, higher effects are exhibited.

Examples of humectants include glycerin, 1,3-butylene glycol, proteins or derivatives or hydrolysates thereof, and salts thereof (collagen, elastin, etc.), hyaluronic acid and salts thereof, amino acids and derivatives thereof, sugars, D-panthenol and derivatives thereof, glycolipid, phospholipid, ceramide, urea, mucin, almond extract, avocado extract, altea extract, hot spring water, aloe extract, usvenia oyster extract, onionis extract, oat extract , Glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, quince seed extract, clara extract, gardenia extract, grapefruit extract, watercress extract, gentian extract, gentian extract, burdock Extract, com Extract, Saisin extract, Cactus extract, Savons extract, Hawthorn extract, Giant extract, Shimotake extract, Ginger extract, Mallow extract, Mulberry extract, Tajikoshi ( Thyme) extract, Cordyceps extract, dodami extract, mint extract, pearl barley extract, hamamelis extract, cypress extract, coltsfoot extract, grape extract, prune extract, loofah extract, bodaiju extract, hop Extract, pine extract, quince extract, maroni extract, melissa extract, cornflower extract, lily extract, lime extract, lavender extract, apple extract, rice and rice extract, black currant extract, Ibukitora noo extract, Neubara (agetsu) extract, Ezoukogi extract, Such as algae extract, and the like.
Examples of moisturizing (emollient) agents by sealing the skin surface include jojoba oil, macadamia nut oil, olive oil, apricot oil, peach seed oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, almond oil. , Sesame oil, sesame oil, borage (borage) oil, cacao butter, shea butter and the like.

  Examples of the blood circulation promoter include a yuzu extract, an arnica extract, a red pepper tincture, a ginger extract, and γ-oryzanol.

  In the external preparation for skin according to the present invention, the blending amount of the rose extract is not particularly limited and can be freely set according to the purpose, but it is 0.0001% by mass or more and 5% by mass or less as the solid content. It is preferable to contain it, and it is more preferable to make it contain 0.001 mass% or more and 3 mass% or less. Within this range, the rose extract can be stably blended and can exhibit a high effect of promoting glutathione production.

  Since the active ingredient of the skin external preparation according to the present invention described above is a naturally derived component, there is a high possibility that it can be safely administered to patients suffering from various diseases. Moreover, there is little need to worry about side effects even if administered continuously for a long period of time.

<Cosmetics>
The glutathione production promoter according to the present invention can be suitably used for cosmetics by utilizing its excellent effect of promoting glutathione production. Since the cosmetic composition according to the present invention contains a rose extract, it is incorporated into the living body as a cosmetic composition to directly act on the glutathione production pathway in the living body to promote glutathione production, as described above. In addition, 1. It promotes energy metabolism, 2. Antioxidation, 3. Detoxification, 4. Antiallergy, 5. Prevention of pigmentation. Therefore, for example, it can be expected to be effective for improving spots, wrinkles, rough skin, improving skin elasticity, and improving texture.

  The cosmetic according to the present invention can be applied to cosmetics of all forms. For example, it can be applied to skin care cosmetics such as lotions, milky lotions, creams, and cosmetics, foundations, concealers, makeup bases, makeup cosmetics such as lipsticks, blushers, eye shadows, and eyeliners, sunscreen cosmetics, etc. .

  In the cosmetic according to the present invention, in addition to the glutathione production promoter according to the present invention, it is possible to freely select one or more components that can be used in normal cosmetics and mix them. For example, bases, preservatives, emulsifiers, colorants, preservatives, surfactants, UV absorbers, antioxidants, moisturizers, UV absorbers, fragrances, antiseptic / antifungal agents, extender pigments, colored pigments, alcohol, All additives that can be usually used in the cosmetic field, such as polyhydric alcohol, water, oil agent, thickener, powder, chelating agent, enzyme, pH adjuster, and the like can be contained.

  In addition, the glutathione production promoter according to the present invention has a low necessity for careful use in combination with other active ingredients because the active ingredient is a naturally-derived ingredient. Therefore, in addition to the glutathione production promoter according to the present invention, other active ingredients can be freely blended in the cosmetic composition according to the present invention as necessary.

  In the cosmetic according to the present invention, the amount of the rose extract is not particularly limited and can be freely set according to the purpose, but is 0.0001% by mass or more and 5% by mass or less as the solid content. Preferably, the content is 0.001% by mass or more and 3% by mass or less. Within this range, the rose extract can be stably blended and can exhibit a high glutathione production promoting effect.

  The cosmetics according to the present invention described above have high safety and can be used continuously for a long period of time because their active ingredients are naturally derived ingredients.

  Hereinafter, the present invention will be described in more detail based on examples. In addition, the Example demonstrated below shows an example of the typical Example of this invention, and, thereby, the range of this invention is not interpreted narrowly.

<Experiment 1: Examination of glutathione production promoting effect of rose rose extract>
In Experiment 1, the effect of promoting the production of glutathione by the rose extract was examined. In the present example, a flower part was used as a specific part of the rose of rose used for extraction.

(1) Preparation of rose extract First, a flower of Rosaceae (Rosa centifolia Linne) is extracted with a 1: 1 mixture of 1,3-butylene glycol and water and filtered. A rose extract was prepared so that the solid content was 1.0% by mass.

(2) Measurement of glutathione production amount Normal human neonatal fibroblasts were pre-cultured, 1 v / v% of the rose extract was added to the medium, and cultured under the respective medium conditions for one week. As a comparison object, a plant grown with only a medium without adding a rose extract was used. After culturing, the medium was removed and washed once with PBS (−), and then fibroblasts were collected.

  Next, after removing the cell debris from the collected cells by centrifugation, the number of cells was counted and adjusted so that the number of cells in each sample was constant. After adjusting the number of each cell, it measured using the commercially available glutathione measurement kit (made by Dojindo). The amount of glutathione produced was determined by measuring the absorbance, and the total amount of glutathione was calculated by creating a calibration curve with a glutathione standard solution having a known concentration.

(5) Results The calculated glutathione production amount per cell is shown in Table 1 and FIG. As shown in Table 1 and FIG. 1, it was found that the amount of glutathione produced by adding the rose extract was increased by about 1.6 times compared to the case of using only the medium. From this result, it was found that the rose extract acts directly on the cell and promotes the production of glutathione in the cell.

<Experiment 2: Preparation of external preparation for skin containing rose extract and examination of its effect>
In this experiment 2, preparation of a skin external preparation containing a rose extract and the effect thereof were examined.

  Preparation of the skin external preparation which concerns on Example 1 and 2 of the composition shown in the following Tables 2 and 3 and examination of the effect were performed. As the rose extract, an extract extracted by the same method as in Experiment 1 (1.0% by mass as the solid content) was used.

[Example 1: Preparation of ointment]
An ointment was prepared by the following production method.
(Manufacturing method)
A. A part of the following components (3), (4) and (9) were mixed by heating and kept at 75 ° C.
B. The following components (1), (2), (7) and (8) were mixed by heating and kept at 75 ° C.
C. B was gradually added to A, and (5) and (6) dissolved in the remainder of component (9) were added while cooling this, to obtain an ointment according to Example 1.

(effect)
The ointment according to Example 1 has excellent temporal stability, and is applied to the skin to promote the production of glutathione in the skin, thereby improving stains, wrinkles, rough skin, improved skin elasticity, and improved texture. Met.

[Example 2: Preparation of cataplasm]
A cataplasm was prepared by the following production method.
(Manufacturing method)
A. The following components (1), (3), (4), (6) to (8) and (10) were mixed and stirred while maintaining at 70 ° C.
B. The following components (2) and (9) were mixed.
C. The above B was added to the previous A, mixed and then cooled, and the component (5) was uniformly dispersed to obtain a poultice according to Example 2.

(effect)
The cataplasm according to Example 2 is excellent in stability over time, and when applied to the skin, promotes the production of glutathione in the skin, thereby improving spots, wrinkles, rough skin, improved skin elasticity, and texture. It was a poultice.

<Experiment 3: Preparation of cosmetic containing rose extract and examination of its effect>
In Experiment 3, the preparation of a cosmetic containing a rose extract and the effect thereof were examined.

  The preparation of cosmetics according to Examples 3 to 10 having the compositions shown in Tables 4 to 11 below and the effects thereof were examined. As the rose extract, an extract extracted by the same method as in Experiment 1 (1.0% by mass as the solid content) was used.

[Example 3: Preparation of lotion]
A lotion was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (10) were mixed and dissolved.
B. The following components (11) to (17) were mixed and dissolved.
C. A lotion according to Example 3 was obtained by adding B to A and mixing uniformly.

(effect)
The lotion according to Example 3 is excellent in stability over time, and when applied to the skin, promotes the production of glutathione in the skin, thereby improving spots, wrinkles, rough skin, improved skin elasticity, and texture. It was lotion.

[Example 4: Preparation of cream]
A cream was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (10) were dissolved by heating and kept at 70 ° C.
B. The following components (11) to (20) were dissolved by heating and kept at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. C was cooled, the following component (21) was added and mixed, and the cream according to Example 4 was obtained.

(effect)
The cream according to Example 4 has excellent temporal stability and is applied to the skin to promote the production of glutathione in the skin, thereby improving spots, wrinkles, rough skin, improved skin elasticity, and texture. Met.

[Example 5: Preparation of cleansing cream]
A cleansing cream was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) were dissolved by heating and kept at 70 ° C.
B. The following components (10) to (14) were dissolved by heating and kept at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. C was cooled, the following component (15) was added and mixed, and the cleansing cream concerning Example 5 was obtained.

(effect)
The cleansing cream according to Example 5 is excellent in stability over time, and is applied to the skin to promote the production of glutathione in the skin, thereby improving blots, wrinkles, rough skin, improved skin elasticity, and texture. Cleansing cream.

[Example 6: Preparation of emulsion]
An emulsion was prepared by the following production method.
(Manufacturing method)
A. The following components (13) to (23) were dissolved by heating and maintained at 70 ° C.
B. The following components (1) to (12) were dissolved by heating and kept at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. C was cooled, the following components (24) and (25) were added and mixed, and the emulsion according to Example 6 was obtained.

(effect)
The emulsion according to Example 6 is excellent in stability over time, and is applied to the skin to promote the production of glutathione in the skin, thereby improving stain, wrinkle improvement, skin roughness improvement, skin elasticity improvement, and texture improvement. Met.

Example 7: Pack preparation
A pack was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (7) were mixed and dissolved by heating at 70 ° C.
B. The following components (8) to (13) were mixed and dissolved.
C. The following components (14) to (16) were mixed and dissolved.
D. B was added to A and mixed and cooled, then C was added and mixed to obtain a pack according to Example 7.

(effect)
The pack according to Example 7 has excellent temporal stability, and is applied to the skin to promote the production of glutathione in the skin, thereby improving stains, wrinkles, rough skin, improved skin elasticity, and texture. Met.

[Example 8: Cream foundation (O / W type)]
A cream foundation was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (11) were mixed by heating and maintained at 70 ° C.
B. The following components (12) to (17) were mixed by heating and maintained at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. After cooling C, the following component (18) was added and mixed to obtain a cream foundation (O / W type) according to Example 8.

(effect)
The cream foundation according to Example 8 has excellent stability over time, and is applied to the skin to promote the production of glutathione in the skin, thereby improving stains, wrinkles, rough skin, improved skin elasticity, and texture. It was a cream foundation.

[Example 9: Liquid foundation (O / W type)]
A liquid foundation was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (9) were mixed and dissolved.
B. The following components (20) to (25) were added to A, mixed uniformly, and kept at 70 ° C.
C. The following components (10) to (19) were uniformly dissolved and kept at 70 ° C.
D. B was added to C and emulsified.
E. After cooling D, the following component (26) was added and mixed to obtain a liquid foundation according to Example 9.

(effect)
The liquid foundation according to Example 9 has excellent stability over time, and when applied to the skin, promotes the production of glutathione in the skin, thereby improving blots, wrinkles, rough skin, improved skin elasticity, and texture. It was a liquid foundation.

[Example 10: Sunscreen emulsion]
A sunscreen emulsion was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (10) were mixed and kept at 70 ° C.
B. A part of the following components (11) to (14) and (15) were mixed and kept at 70 ° C.
C. B was added to A and emulsified uniformly.
D. After cooling C, the remainder of component (15) and the following components (16) to (19) were added and mixed to obtain a sunscreen emulsion according to Example 10.

(effect)
The sunscreen emulsion according to Example 10 has excellent stability over time, and when applied to the skin, promotes glutathione production in the skin, thereby improving spots, wrinkles, rough skin, improved skin elasticity, and improved texture. It was a sunscreen latex to let.

Claims (4)

  A glutathione production promoter comprising, as an active ingredient, a rose extract extracted from Rosaceae, Rosa centifolia Linne.   The glutathione production promoter according to claim 1, wherein the rose extract is an extract obtained from a flower of the rose.   A skin external preparation containing the glutathione production promoter according to claim 1 or 2 and a pharmacologically acceptable additive.   Cosmetics containing the glutathione production promoter according to claim 1 or 2.

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