JP2010095503A - Extermination of pathogenic microorganism in oral cavity and improving agent for bacterial flora in oral cavity - Google Patents

Extermination of pathogenic microorganism in oral cavity and improving agent for bacterial flora in oral cavity Download PDF

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JP2010095503A
JP2010095503A JP2008291523A JP2008291523A JP2010095503A JP 2010095503 A JP2010095503 A JP 2010095503A JP 2008291523 A JP2008291523 A JP 2008291523A JP 2008291523 A JP2008291523 A JP 2008291523A JP 2010095503 A JP2010095503 A JP 2010095503A
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oral cavity
agent
bacterial flora
bacteria
oral
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Minoru Takizawa
穣 滝澤
Chitsuyoshi Kawaguchi
秩義 川口
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ACE BIO PRODUCT KK
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ACE BIO PRODUCT KK
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Abstract

<P>PROBLEM TO BE SOLVED: To provide an improving agent for a bacterial flora in oral cavity, a tooth-cleaning agent, a gargle, a coating agent and a gum agent, each comprising a microorganism and a microbial metabolite. <P>SOLUTION: The improving agent for the bacterial flora in oral cavity, the tooth-cleaning agent, the gargle, the coating agent and the gum agent comprise Clostridium butyricum and a metabolite produced by reproductive activity of the Clostridium butyricum. The preparation for oral cavity is useful for prevention and treatment of a periodontal disease, dental caries, gingivitis, inflammation caused by a chemical or physical damage of an oral mucosa, ozostomia and the like. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

日本人の歯周病菌に侵される割合は35歳以上の85%達している、また歯周病菌の悪影響は口腔内にとどまらずバーシャー病、動脈硬化、脳梗塞、心筋梗塞、関節炎、などの要因にも関与している見解も発表されている。
歯周病菌は歯槽膿漏を起因する悪性の菌であり通常は歯垢内で生息している菌でありしかも歯垢は歯間、歯根などの狭隘で複雑な部分に生成集積するのが大部分であるため通常の歯磨きだけでは容易に除去できないため歯槽膿漏の要因とし問題となっている。
虫歯細菌(ミュータンス菌)は細菌同士スクラムを組んだ固まり(バイオフイルムを形成している)バイオフイルムは歯磨きや薬品では破壊することはできない、バイオフイルムという強力なバリアで守られた細菌は糖を分解し歯を溶かす酸を産生する。
歯の表面にベタベタとこびりついている細菌の塊やプラーク(歯垢)食べかす等は口臭の要因となっている
口腔粘膜に発生する炎症(口内炎)の原因は種々あるが大気中の病原微生物などが進入し口腔内にさまざまな感染症を引き起こしている場合が多く存在する。
歯槽膿漏の原因である歯周病菌例
A.菌 Actinobacillus actinomycetemcomitans
P.g菌 porphyromonas gingivalis
P.i菌 prevotella intermedia
B.f菌 bacteroides forsythus
T.d菌 treponema denticola
The incidence of periodontal disease bacteria in Japan has reached 85% over the age of 35, and the adverse effects of periodontal disease bacteria are not limited to the oral cavity, but include factors such as Bercher's disease, arteriosclerosis, cerebral infarction, myocardial infarction, and arthritis. The views that are involved are also announced.
Periodontal bacteria are malignant bacteria that cause alveolar pyorrhea and usually live in the plaque, and plaque is generated and accumulated in narrow and complex parts such as between teeth and roots. Because it is a part, it cannot be easily removed by just normal brushing.
Cavity bacteria (M. mutans) are crumbs of bacteria (forming biofilms). Biofilms cannot be destroyed by toothpaste or chemicals. Bacteria protected by a strong barrier called biofilms are sugar. It produces acid that breaks down and dissolves teeth.
There are various causes of inflammation (stomatitis) that occurs in the oral mucosa, which is a cause of bad breath, such as bacterial clumps and plaques that stick to the surface of the teeth, but there are various pathogenic microorganisms in the atmosphere There are many cases that enter and cause various infections in the oral cavity.
Periodontal disease bacteria that cause alveolar pus Fungus Actinobacillus actinomycetemcomitans
P. g fungus porphyromonas gingivalis
P. i fungus prevotella intermedia
B. f bacteria bacteroides forsys
T. T. d bacteria treponema denticola

発明の概要Summary of the Invention

バイオフイルム等のバリアで守られた歯周病菌などは微生物によって駆逐するのが安全且つ確実な方法であるとの理論に立脚した実験を基に多様な微生物の研究実験を重ねた結果、今回の発明の酪酸菌(Clostridium butyricum)が特効的抗菌作用のある微生物である事を発見し、その酪酸菌に口腔内環境に適合し機能性を充分に発揮する菌質を付加することに成功し発明に至った。As a result of repeated research on various microorganisms based on experiments based on the theory that periodontal disease bacteria protected by barriers such as biofilms are the safe and reliable method to destroy them by microorganisms. It was discovered that the butyric acid bacterium of the invention (Clostridium butyricum) is a microorganism having a special antibacterial action, and succeeded in adding a bacterial substance that is compatible with the oral environment and sufficiently exhibits its functionality to the butyric acid bacterium. It came to.

発明の背景Background of the Invention

既存の口腔内治療は歯槽膿漏、虫歯、歯肉炎、ヘルペス、口内炎、等々の治療と薬品は専門的、個別的、取り組みが中心で口腔内総合管理までには至ってない。
本発明は個別の治療効果のみでなく治療する事によって、口腔内全体の総合衛生確保に加え薬剤が嚥下され消化器官内での健康増進作用の効果が得られる発明である。
一方安全性については既存複数の薬品会社より胃腸薬他多数の製品が数十年前より市販されており立証されている。
The existing oral treatments include alveolar pyorrhea, dental caries, gingivitis, herpes, stomatitis, and other treatments and medicines that are specialized, individual, and focused on efforts, and have not yet reached comprehensive oral management.
The present invention is an invention in which not only individual therapeutic effects but also treatments can be obtained, and in addition to ensuring the overall hygiene of the entire oral cavity, the drug is swallowed to obtain the effect of promoting health in the digestive organs.
On the other hand, safety has been proved by gastrointestinal drugs and many other products on the market for several decades from existing drug companies.

発明の有効性Effectiveness of the invention

1.酪酸菌を含有した歯磨き剤を使用することで口腔内の歯周病菌や虫歯菌の悪玉巣窟を 駆逐し虫歯や歯槽膿漏の要因を排除する。
2.大気中の病原微生物が進入し口腔粘膜に発生する炎症を発症する要因である病原微生 物を駆逐する。
3.喫煙に伴うニコチン、タールによる皮膚障害炎症部位についても修復効果を発揮する 。
4.口腔粘膜を化学的、物理的に損傷することによる炎症部位の修復効果を発揮する。
5.口腔の次行程である食道についても喫煙弊害、病原微生物障害などの予防修復効果を 発揮する。
6.口腔内に残存した酪酸菌は歯間や歯根など有機物を栄養源として生殖活動をすること により酪酸、酢酸、プロピオン酸、ビタミン・B・B12・C、酵素、オリゴ糖 など産出しビフィズス菌や乳酸菌などの善玉菌を増殖する効果があるため口腔内の歯 周病菌や虫歯菌の悪玉巣窟を善玉菌叢に置換し理想的な口腔管理が実現できる。
7.歯磨きなどのメンテナンス時間を大幅に短縮できる。
1. By using a dentifrice containing butyric acid bacteria, it eliminates periodontal disease bacteria and carious fungus nests in the oral cavity and eliminates the causes of dental caries and alveolar pus leakage.
2. Eliminate pathogenic microorganisms that cause inflammation that occurs in the oral mucosa when pathogenic microorganisms in the atmosphere enter.
3. It also has the effect of repairing the sites of inflammation caused by nicotine and tar associated with smoking.
4). It exerts the effect of repairing inflammatory sites by chemically and physically damaging the oral mucosa.
5). The esophagus, the next step of the oral cavity, also exerts preventive and repairing effects such as harmful smoking and pathogenic microorganisms.
6). Butyric acid bacteria remaining in the oral cavity acid by reproductive activities organics such as interdental and root as a nutrient source, acetic acid, propionic acid, vitamin 2 · B 6 · B 12 · C, enzymes, bifidobacteria yielded such oligosaccharides Since it has the effect of proliferating good bacteria such as bacteria and lactic acid bacteria, it is possible to replace the bad nests of periodontal disease bacteria and caries fungus in the oral cavity with the good bacteria flora and realize ideal oral management.
7). Maintenance time for brushing teeth can be greatly reduced.

発明の詳細Details of the invention

口腔内予防の方法を物理的処理(歯ブラシで清掃掻き出し、歯磨き粉で表面を研磨する)から微生物の特性を生かした方式に転換することにより物理的に損傷などなく長時間の歯磨き時間を必要としない画期的な方式である。
使用例:夕食後ブラシのみで歯全体をブラッシングし付着物を簡単に洗い流しブラシに酪酸菌(Clostridium butyricum)末又は、培養エキス(液)を含浸させた歯ブラシにて歯間及び歯根全体に塗布する、翌朝までに口腔内は歯周病菌や虫歯菌は駆除され歯肉炎などの炎症は改善し善玉菌叢に置換される、悪玉バイオフイルムの集積のある場合も持続することでバリヤーを微生物で壊滅させることが可能なる。
歯周病菌の駆逐実験結果 別添写真(参照)
By changing the method of oral prevention from physical treatment (cleaning and scraping with a toothbrush and polishing the surface with toothpaste) to a method that takes advantage of the characteristics of microorganisms, there is no physical damage and long toothbrushing time is not required This is an epoch-making method.
Example of use: After dinner, brush the entire tooth with a brush only, wash away any deposits, and apply to the entire teeth and roots with a toothbrush impregnated with butyric acid bacteria (Clostridium butyricum) powder or culture extract (liquid). By the next morning, periodontal disease and caries are eliminated in the oral cavity, inflammation such as gingivitis is improved and replaced with good bacterial flora, and even if bad biofilm accumulates, the barrier is destroyed by microorganisms It is possible to make it.
Results of expulsion experiment of periodontal disease bacteria

詳細説明Detailed explanation

1.嫌気性微生物である酪酸菌は歯間や歯根など狭隘な部分での生殖活動が適しており、しかも口腔内は酪酸菌の生殖活動に必要な三大要素が最適な条件で揃っている(歯間や歯根には残存有機物があり、温度条件は37℃と最適、適量の水分もある)ため短時間に増殖し口腔内条件を速やかに好条件(善玉菌叢)への変換を図ること出来る。
2.匂いが気になる場合は軽いミント香りなど趣向により付加する。
更に酪酸菌の機能を向上させるため口腔内環境を整えるための水素イオン濃度調整が可能な酪酸菌を開発。
口腔内条件で生殖活動が活性化する条件を付加した酪酸菌を開発。
汎用歯磨き剤使用薬品の影響を受けない菌質の開発例えば▲1▼カルボキシメチル、ロースナトリウム、ラウリル硫酸ナトリウム、ソルビット液等に対して生存確認され歯磨き剤に添加混合した状態での有効性確認済。
3.口腔内病原菌性微生物の駆除及び口腔内菌叢改善剤の性状としては粉状、練り状、液体の三種類を作成できる。
4.安全性について
本発明に使用している酪酸菌(Clostridium butyricum)は60年前に千葉大学宮入欣治教授に依って発見され以後医薬品、飼料添加物として発売され50年以上の実績のある菌であり、粉末錠剤等に加工され胃腸薬など汎用市販さえている使用例は多種ありその安全性は証明済みである。

Figure 2010095503
1. Butyric acid bacteria, which are anaerobic microorganisms, are suitable for reproductive activities in narrow spaces such as between teeth and roots, and the oral cavity has the three major elements necessary for reproductive activities of butyric acid bacteria under optimal conditions (tooth (There is residual organic matter in the spaces and roots, and the temperature condition is optimal at 37 ° C, and there is an appropriate amount of moisture), so it can grow in a short time and the oral condition can be quickly converted to good conditions (good bacterial flora) .
2. If you are worried about the smell, add a light mint scent.
In order to further improve the functions of butyric acid bacteria, we developed butyric acid bacteria that can adjust the hydrogen ion concentration to adjust the oral environment.
Developed butyric acid bacteria with conditions that activate reproductive activity under oral conditions.
Development of fungi that are not affected by chemicals used for general-purpose dentifrices (1) Confirmed survival of carboxymethyl, sodium loose, sodium lauryl sulfate, sorbit solution, etc. .
3. Three types of powders, kneads, and liquids can be created as the extermination of oral pathogenic microorganisms and the properties of the oral flora improving agent.
4). About the safety Butyric acid bacteria (Clostridium butyricum) used in the present invention was discovered by Prof. Shinji Miyairi 60 years ago as a pharmaceutical and feed additive, and has been proven for over 50 years. There are many examples of use that have been processed into powder tablets, etc., and are commercially available, such as gastrointestinal drugs, and their safety has been proven.
Figure 2010095503

Claims (2)

酪酸菌(Clostridium butyricum)を含有する歯周病菌、虫歯菌、歯肉炎、口腔粘膜を化学的、物理的に損傷することによる炎症、口臭、などの予防、治療を図る菌叢改善剤、歯磨き剤、うがい剤、塗布剤、ガム剤。Periodontal fungus containing Clostridium butyricum, caries fungus, gingivitis, fungus improvement agent and dentifrice for the prevention and treatment of inflammation and bad breath caused by chemical and physical damage to oral mucosa Gargles, coatings, gums. 酪酸菌(Clostridium butyricum)の生殖活動によって産出される代謝産物を含有する歯周病菌、虫歯菌、歯肉炎、口腔粘膜を化学的、物理的に損傷することによる炎症、口臭、など予防、治療を図る菌叢改善剤、歯磨き剤、うがい剤、塗布剤、ガム剤。Periodontal disease bacteria, caries fungi, gingivitis containing metabolites produced by reproductive activity of butyric acid bacteria (Clostridium butyricum), inflammation and bad breath caused by chemical and physical damage to oral mucosa, prevention and treatment Bacterial flora improving agent, dentifrice, gargle, coating agent, gum agent.
JP2008291523A 2008-10-17 2008-10-17 Extermination of pathogenic microorganism in oral cavity and improving agent for bacterial flora in oral cavity Pending JP2010095503A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114774331A (en) * 2022-06-02 2022-07-22 广州金天芳颜化妆品有限公司 Compound probiotics, preparation method thereof and application thereof in resisting HP and oral caries

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114774331A (en) * 2022-06-02 2022-07-22 广州金天芳颜化妆品有限公司 Compound probiotics, preparation method thereof and application thereof in resisting HP and oral caries

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