JP2010059097A - Regulator of heart rate alteration containing hesperidin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method comprising the intake of a regulator of a heartbeat fluctuation containing a hesperidin so as to achieve mentally or emotionally healthy conditions heretofore not attainable by the regulation of heartbeat fluctuation. <P>SOLUTION: The method for regulating heartbeat fluctuation comprises taking 20-5,000 mg (in terms of hesperetin) of a hesperidin per dose. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a heart rate variability adjusting agent and a method thereof.

Heart rate variability is a change in the time interval between heartbeats and reflects a mental or emotional state.
Although hesperidins are flavonoids mainly contained in citrus fruits, there has been a report of a nerve function regulator (patent document 1) as an effect of hesperidins. In the application example of this report, there are described cases in which neurological deficits such as neurosis, Meniere's disease, and nervous breakdown have been improved by taking 2 months or more, but there is no effect of adjusting heart rate variability. Furthermore, it is an improvement of chronic dysfunction, not an acute improvement effect. In addition, there are no cases where the mental or emotional state of a healthy person has been improved.
Japanese Patent Laid-Open No. 11-255655

  The problem to be solved is that, until now, it has not been possible to adjust the heart rate variability to achieve a good mental or emotional state.

The heart rate variability of the present invention is evaluated by the heart rate variability index (hereinafter referred to as HRV) obtained by frequency analysis of the R wave interval of the heart rate. This HRV uses the peak power values of the low frequency (LF) component (frequency component of 0.04 to 0.15 Hz) and the high frequency (HF) component (frequency component of 0.15 to 2.00 Hz) obtained by the frequency analysis, etc. It is known as a medically valuable index in terms of the method of quantifying and evaluation index.

The LF component value increases due to an increase in mental tension or the like, and the HF component value shows a high value during a resting state or during sleep, and disappears due to an increase in the degree of tension.

Actually, it is evaluated that the HF component value is mentally stable by increasing the HF component value or decreasing the numerical value of the LF / HF component.

Hesperidins are flavonoids mainly contained in citrus fruits, such as hesperetin, which is an aglycon, hesperidin with a sugar chain attached to it, and enzyme-treated hesperidin (or glycosylated hesperidin) in which sugar is added with cyclodextrin synthase. It is done. In the present invention, any hesperidin is effective.

The active ingredient in the present invention is hesperidin, and the effective intake is preferably 20 to 5000 mg in terms of hesperetin at the time of single intake. In the case of an intake less than these ranges, the active ingredient is reduced, and therefore an effect cannot be expected. Moreover, when more than these ranges, it exceeds the range which can be ingested on a daily basis, and does not make an appropriate intake form.

The effect appears acutely within 6 hours after ingesting an effective amount of hesperidin.

  The present invention has the advantage of adjusting the heart rate variability so that it is in a mentally or emotionally good state.

 The hesperidin composition may be composed of hesperidins alone, but may be a composite composition mixed with food materials, food additives, and pharmaceutical materials.

The hesperidin composition may be in any form, and examples thereof include food and drink product forms such as solid, powder or liquid, pharmaceutical preparation forms such as tablets, capsules and granules, and feed forms.

EXAMPLES Next, although an Example is given and this invention is demonstrated in more detail, this invention is not restrict | limited at all by these Examples.
Example 1
The survey was conducted on 11 healthy female students aged 18 to 22 years old. In a room with a temperature of 22 ° C and a humidity of 50%, ingestion of a 200ml beverage (test product) containing 500mg of enzyme-treated hesperidin heated to 60 ° C (190mg of hesperetin) and a beverage (control product) that is not formulated in a double blind crossover The heart rate variability was measured, and the heart rate variability was obtained as numerical values of the HF component and the LF / HF component. As a result, when the test product was ingested, the HF component was high (FIG. 1), the LF / HF component was low (FIG. 2), and the effect of adjusting heart rate variability was observed until 70 minutes after ingestion, compared with the control product.

(Comparative Example 1)
The survey was conducted on 11 healthy female students aged 18 to 22 years old. In a room with a temperature of 22 ° C and a humidity of 50%, a 200 ml beverage (test product) containing 19 mg of hesperetin warmed to 37 ° C and a beverage (control product) that was not formulated were fed with a double blind crossover, and heart rate variability was measured. For heart rate variability, numerical values of the HF component and the LF / HF component were obtained. As a result, there was no significant difference in the HF component (FIG. 3) and the LF / HF component (FIG. 4) between the test product and the control product, and hesperetin 19 mg was ineffective due to its small amount.

By taking a heart rate variability adjusting agent containing hesperidins, the heart rate variability can be adjusted to a mentally or emotionally good state.

The chronological variation of the HF component (FIG. 1) and the LF / HF component (FIG. 2) of Example 1 was shown as an average of 11 persons.
The time course variation of the HF component (FIG. 3) and the LF / HF component (FIG. 4) of Comparative Example 1 was shown as an average of 11 persons.

Claims (3)

Heart rate variability adjusting agent containing hesperidin The heart rate variability adjusting agent according to claim 1, wherein the hesperidins are hesperetin, hesperidin, and glycosylated hesperidin. Method for adjusting heart rate variability in which hesperidins are taken from 20 mg to 5000 mg in terms of hesperetin when taken once

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