JP2010053122A5 - - Google Patents

Info

Publication number

JP2010053122A5

JP2010053122A5 JP2009173561A JP2009173561A JP2010053122A5 JP 2010053122 A5 JP2010053122 A5 JP 2010053122A5 JP 2009173561 A JP2009173561 A JP 2009173561A JP 2009173561 A JP2009173561 A JP 2009173561A JP 2010053122 A5 JP2010053122 A5 JP 2010053122A5

Authority

JP

Japan

Prior art keywords

synthesis

inhibitor

fatty acid

involved

lipid

Prior art date

2009-07-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 230000015572 biosynthetic process Effects 0.000 claims 9
• 238000003786 synthesis reaction Methods 0.000 claims 9
• 239000003112 inhibitor Substances 0.000 claims 5
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
• 150000002632 lipids Chemical class 0.000 claims 4
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 3
• 102000000452 Acetyl-CoA carboxylase Human genes 0.000 claims 2
• 108010016219 Acetyl-CoA carboxylase Proteins 0.000 claims 2
• 108010018763 Biotin carboxylase Proteins 0.000 claims 2
• 102000015303 Fatty Acid Synthases Human genes 0.000 claims 2
• 108010039731 Fatty Acid Synthases Proteins 0.000 claims 2
• 229940122498 Gene expression inhibitor Drugs 0.000 claims 2
• 235000012000 cholesterol Nutrition 0.000 claims 2
• 230000004136 fatty acid synthesis Effects 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 claims 1
• 229940123239 Cholesterol synthesis inhibitor Drugs 0.000 claims 1
• 239000004375 Dextrin Substances 0.000 claims 1
• 229920001353 Dextrin Polymers 0.000 claims 1
• 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 claims 1
• 108010061414 Hepatocyte Nuclear Factor 1-beta Proteins 0.000 claims 1
• 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 claims 1
• 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims 1
• 101000629597 Homo sapiens Sterol regulatory element-binding protein 1 Proteins 0.000 claims 1
• 101000629605 Homo sapiens Sterol regulatory element-binding protein 2 Proteins 0.000 claims 1
• 241000241413 Propolis Species 0.000 claims 1
• 239000004373 Pullulan Substances 0.000 claims 1
• 229920001218 Pullulan Polymers 0.000 claims 1
• 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 claims 1
• 102100026841 Sterol regulatory element-binding protein 2 Human genes 0.000 claims 1
• YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• -1 cyclic tetrasaccharide Chemical class 0.000 claims 1
• 235000019425 dextrin Nutrition 0.000 claims 1
• 229940069949 propolis Drugs 0.000 claims 1
• 235000019423 pullulan Nutrition 0.000 claims 1
• 229930003231 vitamin Natural products 0.000 claims 1
• 235000013343 vitamin Nutrition 0.000 claims 1
• 239000011782 vitamin Substances 0.000 claims 1
• 229940088594 vitamin Drugs 0.000 claims 1
• 150000003700 vitamin C derivatives Chemical class 0.000 claims 1
• 150000003722 vitamin derivatives Chemical class 0.000 claims 1