JP2010037329A - Practical method for reducing esters or lactones - Google Patents
Practical method for reducing esters or lactones Download PDFInfo
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- JP2010037329A JP2010037329A JP2009150401A JP2009150401A JP2010037329A JP 2010037329 A JP2010037329 A JP 2010037329A JP 2009150401 A JP2009150401 A JP 2009150401A JP 2009150401 A JP2009150401 A JP 2009150401A JP 2010037329 A JP2010037329 A JP 2010037329A
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- viii
- metal complex
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- 150000002148 esters Chemical class 0.000 title claims abstract description 43
- 150000002596 lactones Chemical class 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 33
- 238000006243 chemical reaction Methods 0.000 claims abstract description 57
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229910052723 transition metal Inorganic materials 0.000 claims abstract description 33
- 150000003624 transition metals Chemical class 0.000 claims abstract description 33
- 230000009467 reduction Effects 0.000 claims abstract description 24
- -1 1,2,3,4,5-pentamethylcyclopentadienyl Chemical group 0.000 claims description 28
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 24
- 239000002585 base Substances 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 239000003446 ligand Substances 0.000 claims description 18
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical group C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- 150000004703 alkoxides Chemical class 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052707 ruthenium Inorganic materials 0.000 claims description 5
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 5
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical group [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 4
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 4
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 4
- RCIBIGQXGCBBCT-UHFFFAOYSA-N phenyl isocyanide Chemical group [C-]#[N+]C1=CC=CC=C1 RCIBIGQXGCBBCT-UHFFFAOYSA-N 0.000 claims description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
- YUWBVKYVJWNVLE-UHFFFAOYSA-N [N].[P] Chemical compound [N].[P] YUWBVKYVJWNVLE-UHFFFAOYSA-N 0.000 claims description 3
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 claims description 3
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- 239000011574 phosphorus Substances 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 abstract description 12
- 150000001298 alcohols Chemical class 0.000 abstract description 9
- 150000002009 diols Chemical class 0.000 abstract description 6
- 150000004678 hydrides Chemical class 0.000 abstract description 6
- 230000002829 reductive effect Effects 0.000 abstract description 6
- 150000004696 coordination complex Chemical class 0.000 abstract description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 39
- 238000006722 reduction reaction Methods 0.000 description 22
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 20
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000007810 chemical reaction solvent Substances 0.000 description 12
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 239000012327 Ruthenium complex Substances 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 230000001012 protector Effects 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000012300 argon atmosphere Substances 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 150000003949 imides Chemical class 0.000 description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- 239000010935 stainless steel Substances 0.000 description 6
- 150000002118 epoxides Chemical class 0.000 description 5
- 150000002576 ketones Chemical class 0.000 description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000035484 reaction time Effects 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 125000003172 aldehyde group Chemical group 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 239000003638 chemical reducing agent Substances 0.000 description 3
- 238000007872 degassing Methods 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000002524 organometallic group Chemical group 0.000 description 3
- 108090000765 processed proteins & peptides Chemical group 0.000 description 3
- 125000006239 protecting group Chemical group 0.000 description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical compound C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 229910018286 SbF 6 Inorganic materials 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 2
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 150000001721 carbon Chemical group 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000004438 haloalkoxy group Chemical group 0.000 description 2
- 125000001188 haloalkyl group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 239000002815 homogeneous catalyst Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 229910052762 osmium Inorganic materials 0.000 description 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 125000000168 pyrrolyl group Chemical group 0.000 description 2
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- SYTBZMRGLBWNTM-SNVBAGLBSA-N (R)-flurbiprofen Chemical compound FC1=CC([C@H](C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-SNVBAGLBSA-N 0.000 description 1
- GETTZEONDQJALK-UHFFFAOYSA-N (trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=CC=C1 GETTZEONDQJALK-UHFFFAOYSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- VYXHVRARDIDEHS-UHFFFAOYSA-N 1,5-cyclooctadiene Chemical compound C1CC=CCCC=C1 VYXHVRARDIDEHS-UHFFFAOYSA-N 0.000 description 1
- 239000004912 1,5-cyclooctadiene Substances 0.000 description 1
- VOGSDFLJZPNWHY-UHFFFAOYSA-N 2,2-difluoroethanol Chemical compound OCC(F)F VOGSDFLJZPNWHY-UHFFFAOYSA-N 0.000 description 1
- QGHNDAKWOGAJHS-UHFFFAOYSA-N 2-Phenylbutyrolactone Chemical compound O=C1OCCC1C1=CC=CC=C1 QGHNDAKWOGAJHS-UHFFFAOYSA-N 0.000 description 1
- WKXZJCKWUCBECD-UHFFFAOYSA-N 2-fluoropropan-1-ol Chemical compound CC(F)CO WKXZJCKWUCBECD-UHFFFAOYSA-N 0.000 description 1
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 description 1
- BVDKYMGISZDCIY-UHFFFAOYSA-N 2-phenylbutane-1,4-diol Chemical compound OCCC(CO)C1=CC=CC=C1 BVDKYMGISZDCIY-UHFFFAOYSA-N 0.000 description 1
- OALYTRUKMRCXNH-UHFFFAOYSA-N 5-pentyloxolan-2-one Chemical compound CCCCCC1CCC(=O)O1 OALYTRUKMRCXNH-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C1C)C2(C)C1(*1(PCCN1)Cl)C(C*)=C(C)C2C Chemical compound CC(C1C)C2(C)C1(*1(PCCN1)Cl)C(C*)=C(C)C2C 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- XMUZQOKACOLCSS-UHFFFAOYSA-N [2-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=CC=C1CO XMUZQOKACOLCSS-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical group 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 238000011914 asymmetric synthesis Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000006015 bromomethoxy group Chemical group 0.000 description 1
- 125000005997 bromomethyl group Chemical group 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 1
- 229910000024 caesium carbonate Inorganic materials 0.000 description 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 125000004651 chloromethoxy group Chemical group ClCO* 0.000 description 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000005695 dehalogenation reaction Methods 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 125000004914 dipropylamino group Chemical group C(CC)N(CCC)* 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- GZKHDVAKKLTJPO-UHFFFAOYSA-N ethyl 2,2-difluoroacetate Chemical compound CCOC(=O)C(F)F GZKHDVAKKLTJPO-UHFFFAOYSA-N 0.000 description 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 description 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000010506 ionic fission reaction Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- 229910000032 lithium hydrogen carbonate Inorganic materials 0.000 description 1
- JILPJDVXYVTZDQ-UHFFFAOYSA-N lithium methoxide Chemical compound [Li+].[O-]C JILPJDVXYVTZDQ-UHFFFAOYSA-N 0.000 description 1
- LZWQNOHZMQIFBX-UHFFFAOYSA-N lithium;2-methylpropan-2-olate Chemical compound [Li+].CC(C)(C)[O-] LZWQNOHZMQIFBX-UHFFFAOYSA-N 0.000 description 1
- AZVCGYPLLBEUNV-UHFFFAOYSA-N lithium;ethanolate Chemical compound [Li+].CC[O-] AZVCGYPLLBEUNV-UHFFFAOYSA-N 0.000 description 1
- HQRPHMAXFVUBJX-UHFFFAOYSA-M lithium;hydrogen carbonate Chemical compound [Li+].OC([O-])=O HQRPHMAXFVUBJX-UHFFFAOYSA-M 0.000 description 1
- HAUKUGBTJXWQMF-UHFFFAOYSA-N lithium;propan-2-olate Chemical compound [Li+].CC(C)[O-] HAUKUGBTJXWQMF-UHFFFAOYSA-N 0.000 description 1
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 1
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- BBKPDHOKNRMWQN-UHFFFAOYSA-N nonane-1,4-diol Chemical compound CCCCCC(O)CCCO BBKPDHOKNRMWQN-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
- WQKGAJDYBZOFSR-UHFFFAOYSA-N potassium;propan-2-olate Chemical compound [K+].CC(C)[O-] WQKGAJDYBZOFSR-UHFFFAOYSA-N 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 150000003303 ruthenium Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- WBQTXTBONIWRGK-UHFFFAOYSA-N sodium;propan-2-olate Chemical compound [Na+].CC(C)[O-] WBQTXTBONIWRGK-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Chemical compound [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 description 1
- 125000005297 thienyloxy group Chemical group S1C(=CC=C1)O* 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C07C29/149—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B31/00—Reduction in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
本発明は、医農薬中間体の製造技術として重要なエステル類およびラクトン類の還元方法に関する。 The present invention relates to a method for reducing esters and lactones that are important as production techniques for pharmaceutical and agrochemical intermediates.
エステル類からアルコール類への還元は、水素化アルミニウムリチウム等のヒドリド還元剤を量論的に用いる方法が多用されている(ラクトン類からジオール類への還元も同様)。一方、遷移金属を触媒とする水素ガス(H2)による還元、特に、再現性が高い均一系触媒を用いる方法は、研究が充分に成されていない(非特許文献1)。最近、均一系のルテニウム錯体を用いる水素化が報告されたが、触媒活性を発現するには特徴的な配位子を必要とする(特許文献1、非特許文献2)。 For the reduction of esters to alcohols, a method in which a hydride reducing agent such as lithium aluminum hydride is used stoichiometrically is frequently used (the same applies to the reduction of lactones to diols). On the other hand, reduction with hydrogen gas (H 2 ) using a transition metal as a catalyst, particularly a method using a homogeneous catalyst with high reproducibility, has not been sufficiently studied (Non-patent Document 1). Recently, hydrogenation using a homogeneous ruthenium complex has been reported, but a characteristic ligand is required to exhibit catalytic activity (Patent Document 1, Non-Patent Document 2).
本発明で用いる8(VIII)族遷移金属錯体は、塩基および水素ガスの共存下に、ケトン類、エポキシド類およびイミド類の還元に有効であることが報告されている(非特許文献3から5)。しかしながら、これらの基質に比べて還元が格段に困難なエステル類およびラクトン類への適用は一切報告されていない。 The group 8 (VIII) transition metal complex used in the present invention has been reported to be effective for the reduction of ketones, epoxides and imides in the presence of a base and hydrogen gas (Non-Patent Documents 3 to 5). ). However, no application has been reported to esters and lactones which are much more difficult to reduce than these substrates.
本発明の目的は、エステル類およびラクトン類の実用的な還元方法を提供することにある。 An object of the present invention is to provide a practical method for reducing esters and lactones.
ヒドリド還元剤を量論的に用いる方法は、該還元剤が高価で取り扱いに注意がいること、後処理が煩雑で廃棄物が多いことから大量規模での生産には不向きであった。よって、この様な問題を伴わない水素ガスを用いる還元、特に、工業化に向けたスケールアップが比較的容易に行える均一系触媒を用いる方法が強く望まれていた。 The method of using a hydride reducing agent in a stoichiometric manner is not suitable for production on a large scale because the reducing agent is expensive and careful in handling, and the post-treatment is complicated and waste is large. Accordingly, there has been a strong demand for a reduction method using hydrogen gas that does not involve such a problem, in particular, a method using a homogeneous catalyst that can be relatively easily scaled up for industrialization.
さらに、本発明では還元が格段に困難なエステル類およびラクトン類を対象とするため、高活性な触媒を設計する必要がある。この様な場合、多くの知見があり、配位子の変更が比較的容易に行える金属錯体を選択することが得策である。本発明で用いる8(VIII)族遷移金属錯体は、この様な要件を正に備えており好適である。しかしながら、該金属錯体から誘導される触媒系がエステル類およびラクトン類の還元に有効であるかは全く不明であり、この有効性を明らかにすることが本発明の課題である。 Furthermore, since the present invention targets esters and lactones that are extremely difficult to reduce, it is necessary to design a highly active catalyst. In such a case, there is a lot of knowledge, and it is a good idea to select a metal complex that can change the ligand relatively easily. The group 8 (VIII) transition metal complex used in the present invention has such a requirement and is suitable. However, it is completely unknown whether the catalyst system derived from the metal complex is effective for the reduction of esters and lactones, and it is an object of the present invention to clarify this effectiveness.
本発明者らは、上記の課題を踏まえて鋭意検討した結果、8(VIII)族遷移金属錯体、塩基および水素ガスの存在下に、エステル類またはラクトン類を、それぞれアルコール類またはジオール類に還元できることを新たに見出した。 As a result of intensive studies based on the above problems, the present inventors reduced esters or lactones to alcohols or diols, respectively, in the presence of a group 8 (VIII) transition metal complex, a base and hydrogen gas. I found out what I can do.
先ず、8(VIII)族遷移金属錯体としては、“シクロペンタジエニル(Cp)基または1,2,3,4,5−ペンタメチルシクロペンタジエニル(Cp*)基、ハロゲン、一酸化炭素、アセトニトリル、フェニルイソシアニドまたはトリフェニルホスフィン、および、窒素−窒素(N−N)またはリン−窒素(P−N)の二座配位子を有する、Fe、RuまたはOs錯体”を用いることができ、“Cp*基、ハロゲンまたはアセトニトリル、および、リンと窒素が2つの炭素を介して結ばれた二座配位子(P−C2−N)を有する、Ru錯体”が好ましく、特に“Cp*RuCl[Ph2P(CH2)2NH2](Ph;フェニル基)”がより好ましいことを新たに明らかにした。 First, group 8 (VIII) transition metal complexes include “cyclopentadienyl (Cp) group or 1,2,3,4,5-pentamethylcyclopentadienyl (Cp * ) group, halogen, carbon monoxide”. Fe, Ru or Os complexes having a bidentate ligand of acetonitrile, phenyl isocyanide or triphenylphosphine, and nitrogen-nitrogen (NN) or phosphorus-nitrogen (PN) can be used , "Cp * group, halogen or acetonitrile, and a bidentate ligand of phosphorus and nitrogen are tied through two carbon (P-C 2 -N), Ru complex" are preferred, particularly "Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ] (Ph; phenyl group) ”was newly clarified.
次に、塩基としては、特に制限はないが、アルカリ金属の水酸化物またはアルコキシドが好ましく、特にアルカリ金属のアルコキシドがより好ましいことを新たに明らかにした。 Next, the base is not particularly limited, but alkali metal hydroxides or alkoxides are preferable, and alkali metal alkoxides are particularly preferable.
また、塩基の使用量としては、ケトン類、エポキシド類およびイミド類の還元に比べて多く用いることにより、所望の反応を効率良く行うことができる。係る好適な塩基の使用量は、8(VIII)族遷移金属錯体1モルに対して15から90モルである。 In addition, as the amount of the base used, a desired reaction can be efficiently performed by using more than the reduction of ketones, epoxides and imides. Such a suitable base is used in an amount of 15 to 90 moles per mole of the group 8 (VIII) transition metal complex.
さらに、水素ガスの圧力としては、ケトン類、エポキシド類およびイミド類の還元に比べて高い条件で行うことにより、所望の反応を効率良く行うことができる。係る好適な水素ガスの圧力は、3から7MPaである。 Furthermore, the desired reaction can be efficiently performed by performing the pressure of hydrogen gas under conditions higher than the reduction of ketones, epoxides, and imides. The pressure of such a suitable hydrogen gas is 3 to 7 MPa.
最後に、反応温度としては、ケトン類、エポキシド類およびイミド類の還元に比べて高い条件で行うことにより、所望の反応を効率良く行うことができる。係る好適な反応温度は、80から150℃である。 Finally, as the reaction temperature, the desired reaction can be efficiently performed by performing the reaction under conditions higher than the reduction of ketones, epoxides and imides. Such a suitable reaction temperature is 80 to 150 ° C.
この様に、エステル類およびラクトン類の実用的な還元方法として有用な方法を見出し、本発明に到達した。 Thus, a useful method was found as a practical method for reducing esters and lactones, and the present invention was achieved.
すなわち、本発明は[発明1]から[発明6]を含み、エステル類およびラクトン類の実用的な還元方法を提供する。 That is, the present invention includes [Invention 1] to [Invention 6] and provides a practical method for reducing esters and lactones.
[発明1]
一般式[1]
[Invention 1]
General formula [1]
[式中、Aはシクロペンタジエニル(Cp)基または1,2,3,4,5−ペンタメチルシクロペンタジエニル(Cp*)基を表し、MはFe、RuまたはOsを表す。さらに、Bはハロゲン、一酸化炭素、アセトニトリル、フェニルイソシアニドまたはトリフェニルホスフィンを表し、Cは窒素−窒素(N−N)またはリン−窒素(P−N)の二座配位子を表す]で示される8(VIII)族遷移金属錯体、塩基および水素ガス(H2)の存在下に、一般式[2] [Wherein, A represents a cyclopentadienyl (Cp) group or a 1,2,3,4,5-pentamethylcyclopentadienyl (Cp * ) group, and M represents Fe, Ru, or Os. Further, B represents halogen, carbon monoxide, acetonitrile, phenyl isocyanide or triphenylphosphine, and C represents a nitrogen-nitrogen (NN) or phosphorus-nitrogen (PN) bidentate ligand. In the presence of the indicated group 8 (VIII) transition metal complex, base and hydrogen gas (H 2 ), the general formula [2]
[式中、R1はアルキル基、置換アルキル基、アルケニル基、置換アルケニル基、芳香環基または置換芳香環基を表し、R2はアルキル基または置換アルキル基を表す]で示されるエステル類、または一般式[3] [Wherein R 1 represents an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an aromatic ring group or a substituted aromatic ring group, and R 2 represents an alkyl group or a substituted alkyl group] Or general formula [3]
{式中、R1−R2は一般式[2]で示されるエステル類のR1とR2が共有結合で結ばれていることを表す}で示されるラクトン類を、それぞれ一般式[4] {Wherein R 1 -R 2 represents that R 1 and R 2 of the ester represented by the general formula [2] are bonded by a covalent bond}, and the lactones represented by the general formula [4 ]
{式中、R1は一般式[2]で示されるエステル類のR1と同じである}で示されるアルコール類、または一般式[5] {Wherein, R 1 is the same as R 1 of esters represented by the general formula [2]} alcohols represented by or general formula [5]
{式中、R1−R2は一般式[2]で示されるエステル類のR1とR2が共有結合で結ばれていることを表す}で示されるジオール類に還元する方法。 {In the formula, R 1 -R 2 represents that R 1 and R 2 of the ester represented by the general formula [2] are bonded by a covalent bond}.
[発明2]
発明1において、一般式[1]で示される8(VIII)族遷移金属錯体が一般式[6]
[Invention 2]
In the invention 1, the group 8 (VIII) transition metal complex represented by the general formula [1] is represented by the general formula [6].
[式中、Cp*は1,2,3,4,5−ペンタメチルシクロペンタジエニル基を表し、Xはハロゲンまたはアセトニトリルを表す。さらに、P−C2−Nはリンと窒素が2つの炭素を介して結ばれた二座配位子であることを表す]で示される8(VIII)族遷移金属錯体であり、さらに塩基がアルカリ金属の水酸化物またはアルコキシドであることを特徴とする、発明1に記載のエステル類またはラクトン類の還元方法。 [Wherein Cp * represents a 1,2,3,4,5-pentamethylcyclopentadienyl group, and X represents halogen or acetonitrile. Further, P—C 2 —N represents a bidentate ligand in which phosphorus and nitrogen are connected via two carbons], and is a group 8 (VIII) transition metal complex represented by The method for reducing esters or lactones according to the invention 1, which is an alkali metal hydroxide or alkoxide.
[発明3]
発明2において、一般式[6]で示される8(VIII)族遷移金属錯体が式[7]
[Invention 3]
In Invention 2, the group 8 (VIII) transition metal complex represented by the general formula [6] is represented by the formula [7].
[式中、Cp*は1,2,3,4,5−ペンタメチルシクロペンタジエニル基を表し、Phはフェニル基を表す]で示される8(VIII)族遷移金属錯体であり、さらに塩基がアルカリ金属のアルコキシドであることを特徴とする、発明2に記載のエステル類またはラクトン類の還元方法。 [Wherein Cp * represents a 1,2,3,4,5-pentamethylcyclopentadienyl group and Ph represents a phenyl group], which is a group 8 (VIII) transition metal complex represented by The method for reducing esters or lactones according to the invention 2, characterized in that is an alkoxide of an alkali metal.
[発明4]
発明1及至発明3の何れかにおいて、塩基の使用量が8(VIII)族遷移金属錯体1モルに対して15から90モルであることを特徴とする、発明1及至発明3の何れかに記載のエステル類またはラクトン類の還元方法。
[Invention 4]
The invention according to any one of invention 1 to invention 3, characterized in that the amount of the base used in any one of invention 1 to invention 3 is 15 to 90 mol with respect to 1 mol of the group 8 (VIII) transition metal complex. Method for reducing esters or lactones.
[発明5]
発明1及至発明4の何れかにおいて、水素ガス(H2)の圧力が3から7MPaであることを特徴とする、発明1及至発明4の何れかに記載のエステル類またはラクトン類の還元方法。
[Invention 5]
The method for reducing esters or lactones according to any one of Inventions 1 to 4, wherein the pressure of hydrogen gas (H 2 ) is 3 to 7 MPa in any one of Inventions 1 to 4.
[発明6]
発明1及至発明5の何れかにおいて、反応温度が80から150℃であることを特徴とする、発明1及至発明5の何れかに記載のエステル類またはラクトン類の還元方法。
[Invention 6]
The method for reducing esters or lactones according to any one of Inventions 1 to 5, wherein the reaction temperature is 80 to 150 ° C in any one of Inventions 1 to 5.
本発明は、還元が格段に困難なエステル類およびラクトン類の還元に適用できる。よって、ヒドリド還元の代替となり、大量規模での生産にも好適に利用できる。 The present invention can be applied to the reduction of esters and lactones that are extremely difficult to reduce. Therefore, it is an alternative to hydride reduction and can be suitably used for mass production.
本発明で用いる8(VIII)族遷移金属錯体は、従来から多くの知見があり、高活性な触媒の設計が比較的容易に行える。さらに、光学活性なN−NまたはP−Nの二座配位子に変更することで不斉合成への展開も期待できる。一方、特許文献1および非特許文献2で開示されたルテニウム錯体は、配位子の些細な変更で触媒活性が消失し、触媒設計に生かせる知見が限られていた。 The 8 (VIII) group transition metal complex used in the present invention has a lot of knowledge so far, and it is relatively easy to design a highly active catalyst. Furthermore, development to asymmetric synthesis can be expected by changing to an optically active NN or PN bidentate ligand. On the other hand, the ruthenium complexes disclosed in Patent Document 1 and Non-Patent Document 2 have lost catalytic activity due to minor changes in the ligand, and the knowledge that can be utilized for catalyst design has been limited.
また、産業上重要なメリットも新たに見出した。本発明で用いる8(VIII)族遷移金属錯体から誘導される触媒系においては、塩基性のイソプロピルアルコールが水素ガスのヘテロリティックな開裂に極めて有効である。そのため、反応溶媒は第一選択的にイソプロピルアルコールが用いられてきた。しかしながら、本発明で対象とするエステル類およびラクトン類の還元では、種々の反応溶媒を用いることができる。よって、イソプロピルアルコールに対する溶解度の低い基質においても、反応溶媒を選択することにより高い基質濃度で反応を行うことができ、高い生産性が期待できる。実際に、ケトン類、エポキシド類およびイミド類の還元に比べて高い基質濃度で反応を行っても、所望の反応を効率良く行うことができる。一方、イソプロピルアルコールに対する溶解度の低いイミド類の還元において、溶解を補助するテトラヒドロフランとの混合溶媒を用いて低い基質濃度で反応を行う例が報告されている(非特許文献5)。 In addition, we found a new industrial advantage. In the catalyst system derived from the group 8 (VIII) transition metal complex used in the present invention, basic isopropyl alcohol is extremely effective for heterolytic cleavage of hydrogen gas. Therefore, isopropyl alcohol has been used as the reaction solvent in the first selection. However, various reaction solvents can be used in the reduction of esters and lactones targeted in the present invention. Therefore, even a substrate with low solubility in isopropyl alcohol can be reacted at a high substrate concentration by selecting a reaction solvent, and high productivity can be expected. Actually, even if the reaction is carried out at a higher substrate concentration than the reduction of ketones, epoxides and imides, the desired reaction can be carried out efficiently. On the other hand, in the reduction of imides having low solubility in isopropyl alcohol, an example in which a reaction is carried out at a low substrate concentration using a mixed solvent with tetrahydrofuran for assisting dissolution has been reported (Non-patent Document 5).
この様に、本発明は、ヒドリド還元の代替となり、高活性な触媒の設計が比較的容易に行え、高い生産性が期待できる、実用的な還元方法である。 Thus, the present invention is a practical reduction method that can be used as a substitute for hydride reduction, and that a highly active catalyst can be designed relatively easily and high productivity can be expected.
本発明のエステル類およびラクトン類の実用的な還元方法について詳細に説明する。 The practical method for reducing the esters and lactones of the present invention will be described in detail.
本発明では、一般式[1]で示される8(VIII)族遷移金属錯体、塩基および水素ガスの存在下に、一般式[2]で示されるエステル類、または一般式[3]で示されるラクトン類を、それぞれ一般式[4]で示されるアルコール類、または一般式[5]で示されるジオール類に還元することができる。 In the present invention, in the presence of a group 8 (VIII) transition metal complex represented by the general formula [1], a base and hydrogen gas, an ester represented by the general formula [2] or represented by the general formula [3] Lactones can be reduced to alcohols represented by general formula [4] or diols represented by general formula [5], respectively.
一般式[1]で示される8(VIII)族遷移金属錯体のAは、Cp基またはCp*基を表す。その中でもCp*基が好ましい。 A of the group 8 (VIII) transition metal complex represented by the general formula [1] represents a Cp group or a Cp * group. Of these, the Cp * group is preferred.
一般式[1]で示される8(VIII)族遷移金属錯体のMは、Fe、RuまたはOsを表す。その中でもFeおよびRuが好ましく、特にRuがより好ましい。 M in the group 8 (VIII) transition metal complex represented by the general formula [1] represents Fe, Ru or Os. Among these, Fe and Ru are preferable, and Ru is particularly preferable.
一般式[1]で示される8(VIII)族遷移金属錯体のBは、塩素、臭素、ヨウ素等のハロゲン、一酸化炭素、アセトニトリル、フェニルイソシアニドまたはトリフェニルホスフィンを表す。その中でもハロゲンおよびアセトニトリルが好ましく、特に塩素がより好ましい。Bの種類によってはカチオン性錯体を採ることもあり、係るカウンターアニオンは、塩素、テトラフルオロボラート(BF4 -)、トリフラートイオン(CF3SO3 -)、ヘキサフルオロホスフェート(PF6 -)、ヘキサフルオロアンチモネート(SbF6 -)等が挙げられる。その中でもCF3SO3 -、PF6 -およびSbF6 -が好ましく、特にCF3SO3 -およびPF6 -がより好ましい。 B of the group 8 (VIII) transition metal complex represented by the general formula [1] represents halogen such as chlorine, bromine and iodine, carbon monoxide, acetonitrile, phenyl isocyanide or triphenylphosphine. Among them, halogen and acetonitrile are preferable, and chlorine is particularly preferable. Depending on the type of B, a cationic complex may be used, and such counter anions include chlorine, tetrafluoroborate (BF 4 − ), triflate ion (CF 3 SO 3 − ), hexafluorophosphate (PF 6 − ), Examples include hexafluoroantimonate (SbF 6 − ). CF 3 SO 3 Among them -, PF 6 - and SbF 6 - are preferable, and CF 3 SO 3 - and PF 6 - are more preferred.
一般式[1]で示される8(VIII)族遷移金属錯体のCは、N−NまたはP−Nの二座配位子を表す。その中でもP−C2−Nが好ましく、特にPh2P(CH2)2NH2がより好ましい。N−N二座配位子は、公知の方法により製造でき、また多くが市販されている。P−N二座配位子は、Aldrichimica ACTA(米国),2008年,第41巻,第1号,p.15−26等により製造できる。代表的なN−NおよびP−N(P−C2−N)の二座配位子を図−1に示すが、これらの代表例に限定されるものではない(代表例のそれぞれの構造式において、任意の炭素原子上に、任意の数で、低級アルキル基が置換できる)。なお、代表例における略記号は次の通りとする。Me;メチル基、Ph;フェニル基、i−Pr;イソプロピル基、t−Bu;tert−ブチル基、Bn;ベンジル基。*は不斉炭素または軸不斉を表し、R体またはS体を採ることができる。*が複数ある場合には、R体またはS体の任意の組み合わせを採ることができる。 C in the group 8 (VIII) transition metal complex represented by the general formula [1] represents an NN or PN bidentate ligand. Among them, P—C 2 —N is preferable, and Ph 2 P (CH 2 ) 2 NH 2 is more preferable. NN bidentate ligands can be produced by known methods, and many of them are commercially available. The PN bidentate ligand is described in Aldrichichima ACTA (USA), 2008, Vol. 41, No. 1, p. 15-26 or the like. Representative N—N and P—N (P—C 2 —N) bidentate ligands are shown in FIG. 1, but are not limited to these representative examples (respective structures of representative examples) In the formula, any number of lower alkyl groups can be substituted on any carbon atom). The abbreviations in the representative examples are as follows. Me: methyl group, Ph: phenyl group, i-Pr: isopropyl group, t-Bu: tert-butyl group, Bn: benzyl group. * Represents an asymmetric carbon or axial asymmetry, and can take R or S form. When there are a plurality of *, any combination of R-form or S-form can be taken.
また、上記のAldrichimica ACTAに記載されたP−N二座配位子も同様に用いることができる。 In addition, the PN bidentate ligand described in Aldrichica ACTA can be used in the same manner.
一般式[1]で示される8(VIII)族遷移金属錯体は、非特許文献4およびOrganometallics(米国),1997年,第16巻,p.1956−1961等により製造できる。本発明の請求項は、触媒系がAMBCと塩基から誘導される2成分調製法を基に記載しているが、水素ガスとの作用(反応溶媒が関与することもある)により同じ触媒活性種{AMHC[式中、Hはヒドリドを表す]}が反応系内で調製できる全ての方法が本発明の請求項に含まれるものとする。具体的に補足すると、2成分調製法{Cp*RuCl[Ph2P(CH2)2NH2]、塩基/水素ガス(反応溶媒が関与することもある)}で調製される触媒活性種のCp*RuH[Ph2P(CH2)2NH2]は、3成分調製法{Cp*RuCl(cod)(cod;1,5−シクロオクタジエン)、Ph2P(CH2)2NH2、塩基/水素ガス(反応溶媒が関与することもある)}でも同様に調製することができる。さらに、非特許文献4で報告されている様に、同じ触媒活性種{Cp*RuH[Ph2P(CH2)2NH2]}は、イソプロピルアルコール中でCp*RuCl[Ph2P(CH2)2NH2]と塩基からも同様に調製できる。予め調製した触媒活性種を用いて水素ガスの存在下に(必要に応じて塩基の共在下に)反応を行うこともできる。具体例以外でもこの様な関係にある全ての調製方法が、本発明の請求項には含まれていることを意味する。 The group 8 (VIII) transition metal complex represented by the general formula [1] is disclosed in Non-Patent Document 4 and Organometallics (USA), 1997, Vol. 16, p. 1956-1961 or the like. The claims of the present invention are based on a two-component preparation method in which the catalyst system is derived from AMBC and a base, but the same catalytically active species due to the action with hydrogen gas (a reaction solvent may be involved). All methods by which {AMHC [wherein H represents hydride]} can be prepared in the reaction system are intended to be included in the claims of the present invention. Specifically supplemented, a catalytically active species prepared by a two-component preparation method {Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ], base / hydrogen gas (which may involve a reaction solvent)} Cp * RuH [Ph 2 P (CH 2 ) 2 NH 2 ] is a three-component preparation method {Cp * RuCl (cod) (cod; 1,5-cyclooctadiene), Ph 2 P (CH 2 ) 2 NH 2 , Base / hydrogen gas (reaction solvent may be involved)} can be similarly prepared. Furthermore, as reported in Non-Patent Document 4, the same catalytically active species {Cp * RuH [Ph 2 P (CH 2 ) 2 NH 2 ]} is Cp * RuCl [Ph 2 P (CH 2 ) It can be similarly prepared from 2 NH 2 ] and a base. The reaction can also be carried out in the presence of hydrogen gas (if necessary, in the presence of a base) using a catalytically active species prepared in advance. All preparation methods having such a relationship other than the specific examples are included in the claims of the present invention.
一般式[1]で示される8(VIII)族遷移金属錯体の使用量は、一般式[2]で示されるエステル類、または一般式[3]で示されるラクトン類1モルに対して触媒量を用いれば良いが、通常は0.1から0.00001モルが好ましく、特に0.05から0.0001モルがより好ましい。 The amount of the group 8 (VIII) transition metal complex represented by the general formula [1] is a catalytic amount relative to 1 mol of the ester represented by the general formula [2] or the lactone represented by the general formula [3]. However, usually 0.1 to 0.00001 mol is preferable, and 0.05 to 0.0001 mol is more preferable.
塩基は、特に制限はないが、炭酸水素リチウム、炭酸水素ナトリウム、炭酸水素カリウム等のアルカリ金属の炭酸水素塩、炭酸リチウム、炭酸ナトリウム、炭酸カリウム、炭酸セシウム等のアルカリ金属の炭酸塩、水酸化リチウム、水酸化ナトリウム、水酸化カリウム等のアルカリ金属の水酸化物、水酸化テトラn−ブチルアンモニウム、リチウムメトキシド、ナトリウムメトキシド、カリウムメトキシド、リチウムエトキシド、ナトリウムエトキシド、カリウムエトキシド、リチウムイソプロポキシド、ナトリウムイソプロポキシド、カリウムイソプロポキシド、リチウムtert−ブトキシド、ナトリウムtert−ブトキシド、カリウムtert−ブトキシド等のアルカリ金属のアルコキシド、トリエチルアミン、ジイソプロピルエチルアミン、1,8−ジアザビシクロ[5.4.0]ウンデセ−7−エン(DBU)等の有機塩基、リチウムビス(トリメチルシリル)アミド、ナトリウムビス(トリメチルシリル)アミド、カリウムビス(トリメチルシリル)アミド等が挙げられる。その中でもアルカリ金属の水酸化物およびアルコキシドが好ましく、特にアルカリ金属のアルコキシドがより好ましい。 The base is not particularly limited, but alkali metal hydrogen carbonates such as lithium hydrogen carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate, alkali metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate and cesium carbonate, hydroxide Alkali metal hydroxides such as lithium, sodium hydroxide, potassium hydroxide, tetra n-butylammonium hydroxide, lithium methoxide, sodium methoxide, potassium methoxide, lithium ethoxide, sodium ethoxide, potassium ethoxide, Alkali metal alkoxides such as lithium isopropoxide, sodium isopropoxide, potassium isopropoxide, lithium tert-butoxide, sodium tert-butoxide, potassium tert-butoxide, triethylamine, diisopropylethyl Examples include amines, organic bases such as 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU), lithium bis (trimethylsilyl) amide, sodium bis (trimethylsilyl) amide, potassium bis (trimethylsilyl) amide, and the like. It is done. Of these, alkali metal hydroxides and alkoxides are preferable, and alkali metal alkoxides are more preferable.
塩基の使用量は、一般式[1]で示される8(VIII)族遷移金属錯体1モルに対して1モル以上を用いれば良いが、所望の反応を効率良く行うには15から90モルが好ましく、実用性を考慮すると特に20から80モルがより好ましい。 The amount of the base used may be 1 mol or more with respect to 1 mol of the group 8 (VIII) transition metal complex represented by the general formula [1], but 15 to 90 mol is required to efficiently perform the desired reaction. In view of practicality, 20 to 80 mol is particularly preferable.
一般式[1]で示される8(VIII)族遷移金属錯体および塩基の使用量の組み合わせは、一般式[2]で示されるエステル類、または一般式[3]で示されるラクトン類1モルに対してそれぞれ触媒量、触媒量以上を用いれば良いが、通常はそれぞれ0.1から0.00001モル、9から0.00015モルが好ましく、特にそれぞれ0.05から0.0001モル、4から0.002モルがより好ましい。 The combination of the use amount of the group 8 (VIII) transition metal complex represented by the general formula [1] and the base is 1 mol of the ester represented by the general formula [2] or the lactone represented by the general formula [3]. The catalyst amount and the catalyst amount or more may be used for each, but usually 0.1 to 0.00001 mol and 9 to 0.00015 mol are preferable respectively, particularly 0.05 to 0.0001 mol and 4 to 0 respectively. 0.002 mol is more preferred.
水素ガス(H2)の使用量は、一般式[2]で示されるエステル類、または一般式[3]で示されるラクトン類1モルに対して2モル以上を用いれば良いが、通常は大過剰が好ましく、特に加圧下での大過剰がより好ましい。係る水素ガスの圧力は、大気圧より高い条件で行えば良いが、所望の反応を効率良く行うには3から7MPaが好ましく、実用性を考慮すると特に4から6MPaがより好ましい。 The amount of hydrogen gas (H 2 ) used may be 2 mol or more per 1 mol of the ester represented by the general formula [2] or the lactone represented by the general formula [3]. An excess is preferred, and a large excess under pressure is particularly preferred. The hydrogen gas pressure may be higher than atmospheric pressure, but 3 to 7 MPa is preferable for efficiently performing a desired reaction, and 4 to 6 MPa is more preferable in consideration of practicality.
一般式[2]で示されるエステル類のR1は、アルキル基、置換アルキル基、アルケニル基、置換アルケニル基、芳香環基または置換芳香環基を表す。その中でも置換アルキル基、置換アルケニル基および置換芳香環基が好ましく、特に該フッ素置換体がより好ましい。 R 1 of the ester represented by the general formula [2] represents an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an aromatic ring group or a substituted aromatic ring group. Among these, a substituted alkyl group, a substituted alkenyl group, and a substituted aromatic ring group are preferable, and the fluorine-substituted product is more preferable.
アルキル基は、炭素数が1から18の、直鎖または枝分れの鎖式、または環式(炭素数が3以上の場合)を採ることができる。アルケニル基は、該アルキル基の、任意の隣り合う2つの炭素原子の単結合が二重結合に、任意の数で置き換わり、該二重結合の立体化学はE体、Z体、またはE体とZ体の混合物を採ることができる。芳香環基は、炭素数が1から18の、フェニル基、ナフチル基、アントリル基等の芳香族炭素水素基、またはピロリル基、フリル基、チエニル基、インドリル基、ベンゾフリル基、ベンゾチエニル基等の窒素原子、酸素原子または硫黄原子等のヘテロ原子を含む芳香族複素環基を採ることができる。 The alkyl group can have a straight chain or branched chain structure having 1 to 18 carbon atoms, or a cyclic structure (when the number of carbon atoms is 3 or more). In the alkenyl group, a single bond of any two adjacent carbon atoms in the alkyl group is replaced with a double bond in any number, and the stereochemistry of the double bond is E-form, Z-form, or E-form. A mixture of Z bodies can be taken. The aromatic ring group is an aromatic carbon hydrogen group having 1 to 18 carbon atoms, such as phenyl group, naphthyl group, anthryl group, or pyrrolyl group, furyl group, thienyl group, indolyl group, benzofuryl group, benzothienyl group, etc. An aromatic heterocyclic group containing a hetero atom such as a nitrogen atom, an oxygen atom or a sulfur atom can be employed.
該アルキル基、アルケニル基または芳香環基は、任意の炭素原子上に、任意の数でさらに任意の組み合わせで、置換基を有することもできる(それぞれ置換アルキル基、置換アルケニル基および置換芳香環基に対応する)。係る置換基としては、フッ素、塩素、臭素、ヨウ素のハロゲン原子、アジド基、ニトロ基、メチル基、エチル基、プロピル基等の低級アルキル基、フルオロメチル基、クロロメチル基、ブロモメチル基等の低級ハロアルキル基、メトキシ基、エトキシ基、プロポキシ基等の低級アルコキシ基、フルオロメトキシ基、クロロメトキシ基、ブロモメトキシ基等の低級ハロアルコキシ基、ジメチルアミノ基、ジエチルアミノ基、ジプロピルアミノ基等の低級アルキルアミノ基、メチルチオ基、エチルチオ基、プロピルチオ基等の低級アルキルチオ基、シアノ基、メトキシカルボニル基、エトキシカルボニル基、プロポキシカルボニル基等の低級アルコキシカルボニル基、アミノカルボニル基(CONH2)、ジメチルアミノカルボニル基、ジエチルアミノカルボニル基、ジプロピルアミノカルボニル基等の低級アミノカルボニル基、アルキニル基、フェニル基、ナフチル基、ピロリル基、フリル基、チエニル基等の芳香環基、フェノキシ基、ナフトキシ基、ピロリルオキシ基、フリルオキシ基、チエニルオキシ基等の芳香環オキシ基、ピペリジル基、ピペリジノ基、モルホリニル基等の脂肪族複素環基、ヒドロキシル基の保護体、アミノ基(アミノ酸またはペプチド残基も含む)の保護体、チオール基の保護体、アルデヒド基の保護体、カルボキシル基の保護体等が挙げられる。なお、本明細書において、次の各用語は、それぞれ次に掲げる意味で用いられる。"低級"とは、炭素数が1から6の、直鎖または枝分れの鎖式、または環式(炭素数3以上の場合)を意味する。"ヒドロキシル基、アミノ基(アミノ酸またはペプチド残基も含む)、チオール基、アルデヒド基およびカルボキシル基の保護基"としては、Protective Groups in Organic Synthesis,Third Edition,1999,John Wiley & Sons,Inc.に記載された保護基等を用いることができる
(2つ以上の官能基を1つの保護基で保護することもできる)。また、"アルキニル基"、"芳香環基"、"芳香環オキシ基"および"脂肪族複素環基"には、ハロゲン原子、アジド基、ニトロ基、低級アルキル基、低級ハロアルキル基、低級アルコキシ基、低級ハロアルコキシ基、低級アルキルアミノ基、低級アルキルチオ基、シアノ基、低級アルコキシカルボニル基、アミノカルボニル基、低級アミノカルボニル基、ヒドロキシル基の保護体、アミノ基(アミノ酸またはペプチド残基も含む)の保護体、チオール基の保護体、アルデヒド基の保護体、カルボキシル基の保護体等が置換することもできる。
The alkyl group, alkenyl group or aromatic ring group may have a substituent on an arbitrary carbon atom in any number and in any combination (substitute alkyl group, substituted alkenyl group and substituted aromatic ring group, respectively). Corresponding to). Examples of such substituents include fluorine, chlorine, bromine, iodine halogen atoms, azide groups, nitro groups, methyl groups, ethyl groups, propyl groups and other lower alkyl groups, fluoromethyl groups, chloromethyl groups, bromomethyl groups and other lower groups. Lower alkyl groups such as haloalkyl groups, methoxy groups, ethoxy groups, propoxy groups, etc., lower haloalkoxy groups such as fluoromethoxy groups, chloromethoxy groups, bromomethoxy groups, dimethylamino groups, diethylamino groups, dipropylamino groups, etc. Lower alkylthio groups such as amino group, methylthio group, ethylthio group and propylthio group, lower alkoxycarbonyl groups such as cyano group, methoxycarbonyl group, ethoxycarbonyl group and propoxycarbonyl group, aminocarbonyl group (CONH 2 ), dimethylaminocarbonyl group , Diethyl Lower aminocarbonyl group such as minocarbonyl group, dipropylaminocarbonyl group, aromatic ring group such as alkynyl group, phenyl group, naphthyl group, pyrrolyl group, furyl group, thienyl group, phenoxy group, naphthoxy group, pyrrolyloxy group, furyloxy Group, aromatic ring oxy group such as thienyloxy group, aliphatic heterocyclic group such as piperidyl group, piperidino group and morpholinyl group, protected hydroxyl group, protected amino group (including amino acid or peptide residue), thiol Group protectors, aldehyde group protectors, carboxyl group protectors, and the like. In the present specification, the following terms are used in the following meanings. “Lower” means straight or branched chain or cyclic (in the case of 3 or more carbon atoms) having 1 to 6 carbon atoms. “Protecting groups for hydroxyl groups, amino groups (including amino acid or peptide residues), thiol groups, aldehyde groups, and carboxyl groups” can be found in Protective Groups in Organic Synthesis, Third Edition, 1999, John Wiley & Sons, Inc. Can be used (two or more functional groups can be protected with one protecting group). “Alkynyl group”, “aromatic ring group”, “aromatic ring oxy group” and “aliphatic heterocyclic group” include halogen atom, azide group, nitro group, lower alkyl group, lower haloalkyl group, lower alkoxy group. , Lower haloalkoxy group, lower alkylamino group, lower alkylthio group, cyano group, lower alkoxycarbonyl group, aminocarbonyl group, lower aminocarbonyl group, protected form of hydroxyl group, amino group (including amino acid or peptide residue) A protector, a protector of a thiol group, a protector of an aldehyde group, a protector of a carboxyl group, and the like can be substituted.
本発明は還元反応であるため、置換基の種類によっては置換基自体が還元される場合もある。しかしながら、特に、フッ素置換体の場合は、水素化分解(還元的脱ハロゲン化)等の副反応が起こり難く、エステル基のα位、β位またはγ位にフッ素原子が導入されることで反応速度が向上する。さらに、α位がフッ素原子で置換された炭素数が2以上の置換アルキル基(α位に水素原子も有する)においては、光学活性体を用いても本発明の反応条件下では殆どラセミ化しない。この様にして得られる光学活性含フッ素アルコール類は重要な医農薬中間体であり、本発明の好適な基質と言える。 Since the present invention is a reduction reaction, the substituent itself may be reduced depending on the type of the substituent. However, in the case of a fluorine-substituted product, side reactions such as hydrogenolysis (reductive dehalogenation) are unlikely to occur, and reaction occurs when a fluorine atom is introduced at the α-position, β-position or γ-position of the ester group. Increases speed. Further, in a substituted alkyl group having 2 or more carbon atoms substituted at the α-position with a fluorine atom (having a hydrogen atom at the α-position), even when an optically active substance is used, it is hardly racemized under the reaction conditions of the present invention. . The optically active fluorinated alcohols thus obtained are important pharmaceutical and agrochemical intermediates and can be said to be suitable substrates of the present invention.
一般式[2]で示されるエステル類のR2は、アルキル基または置換アルキル基を表す。その中でもアルキル基が好ましく、実用性を考慮すると特に低級アルキル基がより好ましい。該アルキル基および置換アルキル基は、一般式[2]で示されるエステル類のR1に記載したアルキル基および置換アルキル基と同じである。 R 2 of the ester represented by the general formula [2] represents an alkyl group or a substituted alkyl group. Among them, an alkyl group is preferable, and a lower alkyl group is more preferable in consideration of practicality. The alkyl group and substituted alkyl group are the same as the alkyl group and substituted alkyl group described in R 1 of the ester represented by the general formula [2].
一般式[3]で示されるラクトン類のR1−R2は、一般式[2]で示されるエステル類のR1とR2が共有結合で結ばれていることを表す。該共有結合は、R1とR2の任意の炭素原子同士間は当然であるが、窒素原子、酸素原子または硫黄原子等のヘテロ原子を介して結ばれることもある。好適なR1およびR2は、一般式[2]で示されるエステル類の場合と同じである。 R 1 -R 2 of the lactone represented by the general formula [3] represents that R 1 and R 2 of the ester represented by the general formula [2] are bonded by a covalent bond. The covalent bond is naturally between any carbon atoms of R 1 and R 2 , but may be bonded through a hetero atom such as a nitrogen atom, an oxygen atom or a sulfur atom. Suitable R 1 and R 2 are the same as in the case of the esters represented by the general formula [2].
反応溶媒は、n−ヘキサン、シクロヘキサン、n−ヘプタン等の脂肪族炭化水素系、ベンゼン、トルエン、α,α,α−トリフルオロトルエン、キシレン、エチルベンゼン、メシチレン等の芳香族炭化水素系、塩化メチレン、クロロホルム、1,2−ジクロロエタン等のハロゲン化炭化水素系、ジエチルエーテル、1,2−ジメトキシエタン、1,4−ジオキサン、テトラヒドロフラン、2−メチルテトラヒドロフラン、tert−ブチルメチルエーテル、ジイソプロピルエーテル、ジエチレングリコールジメチルエーテル、アニソール等のエーテル系、メタノール、エタノール、n−プロピルアルコール、イソプロピルアルコール、n−ブチルアルコール、tert−ブチルアルコール等のアルコール系等が挙げられる。その中でもn−ヘキサン、n−ヘプタン、トルエン、キシレン、ジエチルエーテル、1,4−ジオキサン、テトラヒドロフラン、メタノール、エタノール、イソプロピルアルコールおよびtert−ブチルアルコールが好ましく、特にテトラヒドロフランおよびイソプロピルアルコールがより好ましい。これらの反応溶媒は、単独または組み合わせて用いることができる。一般式[2]で示されるエステル類の還元にイソプロピルアルコールを用いるとエステル交換反応が問題となる場合がある。この様な場合には、テトラヒドロフランを好適に用いることができる。さらに、本発明の好適な目的物である光学活性含フッ素アルコール類の中でも、特に重要な光学活性2−フルオロプロパノール[CH3C*HFCH2OH(*;不斉炭素)]の蒸留において、反応溶媒との分離はテトラヒドロフランの方がイソプロピルアルコールに比べて容易である。一方、一般式[3]で示されるラクトン類の還元にはイソプロピルアルコールが好適である。 The reaction solvent is an aliphatic hydrocarbon such as n-hexane, cyclohexane or n-heptane, an aromatic hydrocarbon such as benzene, toluene, α, α, α-trifluorotoluene, xylene, ethylbenzene or mesitylene, or methylene chloride. Halogenated hydrocarbons such as chloroform and 1,2-dichloroethane, diethyl ether, 1,2-dimethoxyethane, 1,4-dioxane, tetrahydrofuran, 2-methyltetrahydrofuran, tert-butyl methyl ether, diisopropyl ether, diethylene glycol dimethyl ether And ethers such as anisole, and alcohols such as methanol, ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, and tert-butyl alcohol. Among these, n-hexane, n-heptane, toluene, xylene, diethyl ether, 1,4-dioxane, tetrahydrofuran, methanol, ethanol, isopropyl alcohol and tert-butyl alcohol are preferable, and tetrahydrofuran and isopropyl alcohol are more preferable. These reaction solvents can be used alone or in combination. If isopropyl alcohol is used for the reduction of the ester represented by the general formula [2], a transesterification reaction may be a problem. In such a case, tetrahydrofuran can be preferably used. Furthermore, among the optically active fluorinated alcohols that are suitable objects of the present invention, a reaction is particularly important in the distillation of optically active 2-fluoropropanol [CH 3 C * HFCH 2 OH (*; asymmetric carbon)]. Separation from the solvent is easier with tetrahydrofuran than with isopropyl alcohol. On the other hand, isopropyl alcohol is suitable for the reduction of the lactone represented by the general formula [3].
反応溶媒の使用量は、一般式[2]で示されるエステル類、または一般式[3]で示されるラクトン類1モルに対して0.01L(リットル)以上を用いれば良いが、通常は0.05から2Lが好ましく、特に0.1から1.5Lがより好ましい。低い基質濃度で反応を行うと反応速度が低下する場合がある。この様な場合は、好適な反応溶媒の使用量を用いることにより反応速度が向上する。 The reaction solvent may be used in an amount of 0.01 L (liter) or more per 1 mol of the ester represented by the general formula [2] or the lactone represented by the general formula [3]. 0.05 to 2L is preferable, and 0.1 to 1.5L is more preferable. When the reaction is carried out at a low substrate concentration, the reaction rate may decrease. In such a case, the reaction rate is improved by using a suitable amount of the reaction solvent.
反応温度は、50℃以上で行えば良いが、所望の反応を効率良く行うには80から150℃が好ましく、実用性を考慮すると特に85から140℃がより好ましい。 The reaction temperature may be 50 ° C. or higher, but 80 to 150 ° C. is preferable for efficiently performing a desired reaction, and 85 to 140 ° C. is more preferable in consideration of practicality.
反応時間は、特に制限はないが、通常は72時間以内であるが、触媒系、基質および反応条件により異なるため、ガスクロマトグラフィー、薄層クロマトグラフィー、液体クロマトグラフィー、核磁気共鳴等の分析手段により反応の進行状況を追跡し、原料が殆ど消失した時点を反応の終点とすることが好ましい。 The reaction time is not particularly limited, but is usually within 72 hours. However, since it varies depending on the catalyst system, substrate and reaction conditions, analytical means such as gas chromatography, thin layer chromatography, liquid chromatography, nuclear magnetic resonance, etc. It is preferable that the progress of the reaction is followed by the reaction, and the point of time when the raw material has almost disappeared is the end point of the reaction.
後処理は、反応終了液に対して通常の操作を行うことにより、目的とする一般式[4]で示されるアルコール類、または一般式[5]で示されるジオール類を得ることができる。目的物は、必要に応じて、活性炭処理、蒸留、再結晶、カラムクロマトグラフィー等により、高い化学純度に精製することができる。 In the post-treatment, the target alcohols represented by the general formula [4] or diols represented by the general formula [5] can be obtained by performing normal operations on the reaction-terminated liquid. The desired product can be purified to a high chemical purity by activated carbon treatment, distillation, recrystallization, column chromatography or the like, if necessary.
本発明では、一般式[1]で示される8(VIII)族遷移金属錯体、塩基および水素ガスの存在下に、一般式[2]で示されるエステル類、または一般式[3]で示されるラクトン類を、それぞれ一般式[4]で示されるアルコール類、または一般式[5]で示されるジオール類に還元することができる(態様1)。 In the present invention, in the presence of a group 8 (VIII) transition metal complex represented by the general formula [1], a base and hydrogen gas, an ester represented by the general formula [2] or represented by the general formula [3] Lactones can be reduced to alcohols represented by general formula [4] or diols represented by general formula [5], respectively (Aspect 1).
8(VIII)族遷移金属錯体と塩基の、好ましい同士の組み合わせにより、さらに高活性な触媒活性種を調製することができる(態様2)。 A more active catalytically active species can be prepared by a preferred combination of a group 8 (VIII) transition metal complex and a base (Aspect 2).
8(VIII)族遷移金属錯体と塩基の、特により好ましい同士の組み合わせにより、極めて高活性な触媒活性種を調製することができる(態様3)。 An extremely highly active catalytically active species can be prepared by a particularly more preferable combination of a group 8 (VIII) transition metal complex and a base (Aspect 3).
態様1から3と好適な塩基の使用量の組み合わせにより、さらに実用的な還元方法を提供できる(態様4)。 A more practical reduction method can be provided by combining the modes 1 to 3 and a suitable amount of base used (mode 4).
態様1から4と好適な水素ガスの圧力の組み合わせにより、格段に実用的な還元方法を提供できる(態様5)。 A combination of Embodiments 1 to 4 and a suitable hydrogen gas pressure can provide a much more practical reduction method (Aspect 5).
態様1から5と好適な反応温度の組み合わせにより、極めて実用的な還元方法を提供できる(態様6)。 A combination of Embodiments 1 to 5 and a suitable reaction temperature can provide a very practical reduction method (Aspect 6).
実施例により本発明の実施の形態を具体的に説明するが、本発明はこれらの実施例に限定されるものではない。なお、実施例における略記号は次の通りとする。NaOMe;ナトリウムメトキシド、Me;メチル基、Et;エチル基、Ph;フェニル基、i−Pr;イソプロピル基、Cp*;1,2,3,4,5−ペンタメチルシクロペンタジエニル基、Et2O;ジエチルエーテル、ジオキサン;1,4−ジオキサン、THF;テトラヒドロフラン、MeOH;メタノール、IPA;イソプロピルアルコール、t−BuOH;tert−ブチルアルコール、N−C2 *−N;2つの窒素が2つの炭素を介して結ばれた光学活性二座配位子、N−C2−N;2つの窒素が2つの炭素を介して結ばれた二座配位子。
[実施例1から7]
実施例3の実験操作を代表例として下に示す。
Embodiments of the present invention will be specifically described by way of examples, but the present invention is not limited to these examples. The abbreviations in the examples are as follows. NaOMe; sodium methoxide, Me; methyl group, Et; ethyl group, Ph; phenyl group, i-Pr; isopropyl group, Cp * ; 1,2,3,4,5-pentamethylcyclopentadienyl group, Et 2 O; diethyl ether, dioxane; 1,4-dioxane, THF; tetrahydrofuran, MeOH; methanol, IPA; isopropyl alcohol, t-BuOH; tert-butyl alcohol, N—C 2 * —N; An optically active bidentate ligand linked through carbon, N—C 2 —N; a bidentate ligand in which two nitrogens are linked through two carbons.
[Examples 1 to 7]
The experimental operation of Example 3 is shown below as a representative example.
アルゴン雰囲気下、シュレンク管に、下記式 The following formula is applied to a Schlenk tube under an argon atmosphere:
で示されるCp*RuCl[Ph2P(CH2)2NH2]5mg(0.01mmol,0.01eq)、ナトリウムメトキシド13.5mg[0.25mmol,25eq(ルテニウム錯体に対する当量)]、テトラヒドロフラン1mLとエチルベンゾエート150mg(1mmol)を加え、凍結脱気を3回繰り返した。得られた溶液をカニュラーにより、ガラス製内筒を有するステンレス鋼(SUS)製耐圧反応容器に移した。反応容器内を水素ガスで5回置換し、水素圧を5MPaに設定し、100℃で21時間攪拌した。反応終了液のガスクロマトグラフィー分析より、変換率と目的物であるベンジルアルコールの面積百分率(GCエリア%)は、それぞれ100%、99.6%であった。副生物1から3は検出されなかった。 Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ] 5 mg (0.01 mmol, 0.01 eq), sodium methoxide 13.5 mg [0.25 mmol, 25 eq (equivalent to ruthenium complex)], tetrahydrofuran 1 mL and 150 mg (1 mmol) of ethyl benzoate were added, and freeze deaeration was repeated three times. The resulting solution was transferred by cannula to a stainless steel (SUS) pressure-resistant reaction vessel having a glass inner cylinder. The inside of the reaction vessel was replaced with hydrogen gas five times, the hydrogen pressure was set to 5 MPa, and the mixture was stirred at 100 ° C. for 21 hours. From the gas chromatographic analysis of the reaction completed solution, the conversion rate and the area percentage (GC area%) of the target benzyl alcohol were 100% and 99.6%, respectively. By-products 1 to 3 were not detected.
実施例1、2、4から7は、Cp*RuCl[Ph2P(CH2)2NH2]の使用量、ナトリウムメトキシドの使用量、反応溶媒、反応温度および反応時間を変えて、実施例3と同様に行った。実施例1から7の結果を表−1に纏めた。 Examples 1, 2, 4 to 7 were carried out by changing the amount of Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ], sodium methoxide, reaction solvent, reaction temperature and reaction time. Performed as in Example 3. The results of Examples 1 to 7 are summarized in Table 1.
[実施例8から20]
実施例8の実験操作を代表例として下に示す。
[Examples 8 to 20]
The experimental operation of Example 8 is shown below as a representative example.
アルゴン雰囲気下、シュレンク管に、下記式 The following formula is applied to a Schlenk tube under an argon atmosphere:
で示されるCp*RuCl[Ph2P(CH2)2NH2]5mg(0.01mmol,0.01eq)、ナトリウムメトキシド13.5mg[0.25mmol,25eq(ルテニウム錯体に対する当量)]、フタリド134mg(1mmol)とイソプロピルアルコール1mLを加え、凍結脱気を3回繰り返した。得られた溶液をカニュラーにより、ガラス製内筒を有するステンレス鋼(SUS)製耐圧反応容器に移した。反応容器内を水素ガスで5回置換し、水素圧を5MPaに設定し、100℃で21時間攪拌した。反応終了液のガスクロマトグラフィー分析より、変換率と目的物である1,2−ベンゼンジメタノールの面積百分率(GCエリア%)は、それぞれ99.3%、99.3%であった。 Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ] 5 mg (0.01 mmol, 0.01 eq), sodium methoxide 13.5 mg [0.25 mmol, 25 eq (equivalent to ruthenium complex)], phthalide 134 mg (1 mmol) and 1 mL of isopropyl alcohol were added, and freeze degassing was repeated three times. The resulting solution was transferred by cannula to a stainless steel (SUS) pressure-resistant reaction vessel having a glass inner cylinder. The inside of the reaction vessel was replaced with hydrogen gas five times, the hydrogen pressure was set to 5 MPa, and the mixture was stirred at 100 ° C. for 21 hours. From the gas chromatographic analysis of the reaction completed liquid, the conversion rate and the area percentage (GC area%) of 1,2-benzenedimethanol, which was the target product, were 99.3% and 99.3%, respectively.
実施例9から20は、ナトリウムメトキシドの使用量、水素ガスの圧力、反応溶媒および反応温度を変えて、実施例8と同様に行った。実施例8から20の結果を表−2に纏めた。 Examples 9 to 20 were carried out in the same manner as in Example 8, except that the amount of sodium methoxide used, the pressure of hydrogen gas, the reaction solvent and the reaction temperature were changed. The results of Examples 8 to 20 are summarized in Table 2.
[実施例21]
アルゴン雰囲気下、シュレンク管に、下記式
[Example 21]
The following formula is applied to a Schlenk tube under an argon atmosphere:
で示されるCp*RuCl[Ph2P(CH2)2NH2]5mg(0.01mmol,0.01eq)、ナトリウムメトキシド13.5mg[0.25mmol,25eq(ルテニウム錯体に対する当量)]、イソプロピルアルコール1mLとγ−ノナノイックラクトン156mg(1mmol)を加え、凍結脱気を3回繰り返した。得られた溶液をカニュラーにより、ガラス製内筒を有するステンレス鋼(SUS)製耐圧反応容器に移した。反応容器内を水素ガスで5回置換し、水素圧を5MPaに設定し、100℃で21時間攪拌した。反応終了液のガスクロマトグラフィー分析より、変換率と目的物である1,4−ノナンジオールの面積百分率(GCエリア%)は、それぞれ98.8%、98.1%であった。 Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ] 5 mg (0.01 mmol, 0.01 eq), sodium methoxide 13.5 mg [0.25 mmol, 25 eq (equivalent to ruthenium complex)], isopropyl 1 mL of alcohol and 156 mg (1 mmol) of γ-nonanoic lactone were added, and freeze degassing was repeated three times. The resulting solution was transferred by cannula to a stainless steel (SUS) pressure-resistant reaction vessel having a glass inner cylinder. The inside of the reaction vessel was replaced with hydrogen gas five times, the hydrogen pressure was set to 5 MPa, and the mixture was stirred at 100 ° C. for 21 hours. From the gas chromatographic analysis of the reaction completed liquid, the conversion rate and the area percentage of 1,4-nonanediol (GC area%), which was the target product, were 98.8% and 98.1%, respectively.
実施例21の結果を下のスキームに示す。 The results of Example 21 are shown in the scheme below.
[実施例22]
アルゴン雰囲気下、シュレンク管に、下記式
[Example 22]
The following formula is applied to a Schlenk tube under an argon atmosphere:
で示されるCp*RuCl[Ph2P(CH2)2NH2]5mg(0.01mmol,0.01eq)、ナトリウムメトキシド13.5mg[0.25mmol,25eq(ルテニウム錯体に対する当量)]、イソプロピルアルコール1mLとε―カプロラクトン114mg(1mmol)を加え、凍結脱気を3回繰り返した。得られた溶液をカニュラーにより、ガラス製内筒を有するステンレス鋼(SUS)製耐圧反応容器に移した。反応容器内を水素ガスで5回置換し、水素圧を5MPaに設定し、100℃で21時間攪拌した。反応終了液のガスクロマトグラフィー分析より、変換率と目的物である1,6−ヘキサンジオールの面積百分率(GCエリア%)は、それぞれ84.6%、78.6%であった。 Cp * RuCl [Ph 2 P (CH 2 ) 2 NH 2 ] 5 mg (0.01 mmol, 0.01 eq), sodium methoxide 13.5 mg [0.25 mmol, 25 eq (equivalent to ruthenium complex)], isopropyl 1 mL of alcohol and 114 mg (1 mmol) of ε-caprolactone were added, and freeze degassing was repeated three times. The resulting solution was transferred by cannula to a stainless steel (SUS) pressure-resistant reaction vessel having a glass inner cylinder. The inside of the reaction vessel was replaced with hydrogen gas five times, the hydrogen pressure was set to 5 MPa, and the mixture was stirred at 100 ° C. for 21 hours. From the gas chromatographic analysis of the reaction completed solution, the conversion rate and the area percentage of 1,6-hexanediol (GC area%), which was the target product, were 84.6% and 78.6%, respectively.
実施例22の結果を下のスキームに示す。 The results of Example 22 are shown in the scheme below.
[実施例23から25]
アルゴン雰囲気下、シュレンク管に、Cp*RuCl(N−C2 *−N)(0.03mmol,0.05eq)、カリウムtert−ブトキシド16.8mg[0.15mmol,5eq(ルテニウム錯体に対する当量)]、イソプロピルアルコール1.5mLとα―フェニル−γ−ブチロラクトン97.3mg[0.6mmol(ラセミ体)]を加え、凍結脱気を3回繰り返した。得られた溶液をカニュラーにより、ガラス製内筒を有するステンレス鋼(SUS)製耐圧反応容器に移した。反応容器内を水素ガスで5回置換し、水素圧を5MPaに設定し、所定の反応温度で所定の反応時間攪拌した。反応終了液の(キラル)ガスクロマトグラフィー分析より、変換率と目的物である2−フェニル−1,4−ブタンジオール(光学活性体)の光学純度を測定した。
[Examples 23 to 25]
Cp * RuCl (N—C 2 * —N) (0.03 mmol, 0.05 eq), potassium tert-butoxide 16.8 mg [0.15 mmol, 5 eq (equivalent to ruthenium complex)] in a Schlenk tube under an argon atmosphere Then, 1.5 mL of isopropyl alcohol and 97.3 mg [0.6 mmol (racemic)] of α-phenyl-γ-butyrolactone were added, and freeze deaeration was repeated three times. The resulting solution was transferred by cannula to a stainless steel (SUS) pressure-resistant reaction vessel having a glass inner cylinder. The inside of the reaction vessel was replaced with hydrogen gas five times, the hydrogen pressure was set to 5 MPa, and the mixture was stirred at a predetermined reaction temperature for a predetermined reaction time. From the (chiral) gas chromatographic analysis of the reaction completed solution, the conversion rate and the optical purity of the target product, 2-phenyl-1,4-butanediol (optically active substance), were measured.
実施例23から25は、光学活性二座配位子であるN−C2 *−N、反応温度および反応時間を変えて同様に行った。実施例23から25の結果を表−3に纏めた。 Examples 23 to 25 were carried out in the same manner while changing the optically active bidentate ligand N—C 2 * —N, reaction temperature and reaction time. The results of Examples 23 to 25 are summarized in Table 3.
[実施例26]
アルゴン雰囲気下、シュレンク管に、Cp*RuCl(N−C2−N)(0.01mmol,0.001eq)、ナトリウムメトキシド135mg[2.5mmol,250eq(ルテニウム錯体に対する当量)]、テトラヒドロフラン4.5mLとジフルオロ酢酸エチル1.24g(10mmol)を加え、凍結脱気を3回繰り返した。得られた溶液をカニュラーにより、ガラス製内筒を有するステンレス鋼(SUS)製耐圧反応容器に移した。反応容器内を水素ガスで5回置換し、水素圧を5MPaに設定し、100℃で24時間攪拌した。反応終了液のガスクロマトグラフィー分析より、変換率と目的物である2,2−ジフルオロエタノールの面積百分率(GCエリア%)は、それぞれ66%、100%であった。
[Example 26]
3. Cp * RuCl (N—C 2 —N) (0.01 mmol, 0.001 eq), sodium methoxide 135 mg [2.5 mmol, 250 eq (equivalent to ruthenium complex)], tetrahydrofuran 4 in a Schlenk tube under an argon atmosphere. 5 mL and 1.24 g (10 mmol) of ethyl difluoroacetate were added, and freeze deaeration was repeated three times. The resulting solution was transferred by cannula to a stainless steel (SUS) pressure-resistant reaction vessel having a glass inner cylinder. The inside of the reaction vessel was replaced with hydrogen gas five times, the hydrogen pressure was set to 5 MPa, and the mixture was stirred at 100 ° C. for 24 hours. From the gas chromatographic analysis of the reaction completion liquid, the conversion rate and the area percentage (GC area%) of 2,2-difluoroethanol which is the target product were 66% and 100%, respectively.
実施例26の結果を下のスキームに示す。 The results of Example 26 are shown in the scheme below.
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WO2010114151A1 (en) * | 2009-03-31 | 2010-10-07 | 住友化学株式会社 | Method for producing alcohol compound and catalyst therefor |
WO2012105431A1 (en) | 2011-02-03 | 2012-08-09 | セントラル硝子株式会社 | METHOD FOR PRODUCING β-FLUOROALCOHOL |
JP2014114257A (en) * | 2012-12-12 | 2014-06-26 | Takasago Internatl Corp | Method for reducing halogen-substituted benzoate ester using ruthenium carbonyl complex |
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CN102766024B (en) * | 2012-08-09 | 2015-08-12 | 西安近代化学研究所 | The preparation method of difluoroethanol |
CN104829432B (en) * | 2015-03-18 | 2017-02-01 | 武汉工程大学 | Method of preparing fluoroalcohol |
RU2646222C2 (en) * | 2016-07-06 | 2018-03-02 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Method of producing 2-[(oxyphenyl)methyl]butane-1,4-diols |
CN108610237B (en) * | 2018-05-29 | 2021-07-23 | 复旦大学 | Method for synthesizing o-xylene glycol derivative |
ES2953133T3 (en) * | 2019-12-17 | 2023-11-08 | Evonik Oxeno Gmbh & Co Kg | 3,3',3''-(cyclohexane-1,2,4-triyl)tripropionic acid trimethyl ester |
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WO2005092825A1 (en) * | 2004-03-29 | 2005-10-06 | Nagoya Industrial Science Research Institute | Process for production of optically active alcohols |
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WO2005092825A1 (en) * | 2004-03-29 | 2005-10-06 | Nagoya Industrial Science Research Institute | Process for production of optically active alcohols |
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WO2010114151A1 (en) * | 2009-03-31 | 2010-10-07 | 住友化学株式会社 | Method for producing alcohol compound and catalyst therefor |
WO2012105431A1 (en) | 2011-02-03 | 2012-08-09 | セントラル硝子株式会社 | METHOD FOR PRODUCING β-FLUOROALCOHOL |
JP2013049660A (en) * | 2011-02-03 | 2013-03-14 | Central Glass Co Ltd | PRODUCTION METHOD OF β-FLUOROALCOHOLS |
CN103347844A (en) * | 2011-02-03 | 2013-10-09 | 中央硝子株式会社 | Method for producing ss-fluoroalcohol |
US8658840B2 (en) | 2011-02-03 | 2014-02-25 | Central Glass Company, Limited | Method for producing β-fluoroalcohol |
JP2014114257A (en) * | 2012-12-12 | 2014-06-26 | Takasago Internatl Corp | Method for reducing halogen-substituted benzoate ester using ruthenium carbonyl complex |
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