JP2010005062A - コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法 - Google Patents
コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法 Download PDFInfo
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- JP2010005062A JP2010005062A JP2008166731A JP2008166731A JP2010005062A JP 2010005062 A JP2010005062 A JP 2010005062A JP 2008166731 A JP2008166731 A JP 2008166731A JP 2008166731 A JP2008166731 A JP 2008166731A JP 2010005062 A JP2010005062 A JP 2010005062A
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/653—Coherent methods [CARS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/653—Coherent methods [CARS]
- G01N2021/656—Raman microprobe
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
【解決手段】振動数の異なる2つの近赤外フェムト秒レーザ光を生体内物質に照射し、この2つの近赤外フェムト秒レーザ光の振動数差が、生体内物質の固有振動数に一致することによって生体内物質から発せられるコヒーレントアンチストークスラマン散乱光を検出し、得られるラマン散乱スペクトルのピーク強度に基づいて、生体内物質の量を測定する生体内物質量測定方法を提供する。
【選択図】図5
Description
この生体内物質量測定方法において、測定対象とする生体内物質は糖化ヘモグロビンとすることができる。
S 標本
V 血管
1,2 パルスレーザ発生装置
11 ガルバノミラー
12 群速度調整系
21 ダイクロイックミラー
22 フォローファイバー
3 対物レンズ
31 焦点位置調節機構
4 集光レンズ
5 ミラー
6 分光器
7 CCDカメラユニット
71 バンドパスフィルター
Claims (2)
- 振動数の異なる2つの近赤外フェムト秒レーザ光を生体内物質に照射し、この2つの近赤外フェムト秒レーザ光の振動数差が、生体内物質の固有振動数に一致することによって生体内物質から発せられるコヒーレントアンチストークスラマン散乱光を検出し、得られるラマン散乱スペクトルのピーク強度に基づいて、生体内物質の量を測定する生体内物質量測定方法。
- 前記生体内物質が糖化ヘモグロビンである請求項1記載の生体内物質量測定方法。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008166731A JP4618341B2 (ja) | 2008-06-26 | 2008-06-26 | コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法 |
US12/486,290 US20090324498A1 (en) | 2008-06-26 | 2009-06-17 | Method of measuring quantity of in-vivo substance by use of coherent anti-stokes raman scattered light |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008166731A JP4618341B2 (ja) | 2008-06-26 | 2008-06-26 | コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010005062A true JP2010005062A (ja) | 2010-01-14 |
JP4618341B2 JP4618341B2 (ja) | 2011-01-26 |
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JP2008166731A Expired - Fee Related JP4618341B2 (ja) | 2008-06-26 | 2008-06-26 | コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法 |
Country Status (2)
Country | Link |
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US (1) | US20090324498A1 (ja) |
JP (1) | JP4618341B2 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013088746A1 (ja) | 2011-12-16 | 2013-06-20 | 独立行政法人理化学研究所 | レーザー走査型生体内特定物質量計測方法 |
JP2017203646A (ja) * | 2016-05-09 | 2017-11-16 | 株式会社エーティーエー | 周波数変調cars計測装置 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014018599A (ja) * | 2012-07-24 | 2014-02-03 | Sony Corp | 分子濃度測定装置及び分子濃度測定方法 |
CN105911046B (zh) * | 2016-07-04 | 2018-09-04 | 哈尔滨工业大学(威海) | 一种基于频数分布原理的滤波方法 |
CN106645081B (zh) * | 2016-10-26 | 2019-11-12 | 复旦大学 | 基于快速扫描光程的受激拉曼光谱成像系统 |
CN109856112B (zh) * | 2017-11-30 | 2020-05-22 | 中国科学院大连化学物理研究所 | 一种基于cars的断层扫描成像装置、检测系统及方法 |
Citations (5)
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JP2006524091A (ja) * | 2003-04-24 | 2006-10-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | カテーテルヘッド |
JP2007509322A (ja) * | 2003-10-17 | 2007-04-12 | インテル・コーポレーション | 表面増感コヒーレント反ストークスラマン分光を用いた少数の分子を検出する方法および装置 |
JP2007175242A (ja) * | 2005-12-27 | 2007-07-12 | Sharp Corp | 測定装置、測定プログラム及びコンピュータ読み取り可能な記録媒体 |
JP2007525662A (ja) * | 2003-12-30 | 2007-09-06 | インテル・コーポレーション | ラマン分光法を使用して生物試料のタンパク質プロファイルを得る方法 |
JP2007278768A (ja) * | 2006-04-04 | 2007-10-25 | Toshiba Corp | 顕微鏡装置 |
Family Cites Families (8)
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GB1511188A (en) * | 1975-06-05 | 1978-05-17 | Allied Chem | Method of and apparatus for analyzing light |
JP3977947B2 (ja) * | 1998-12-07 | 2007-09-19 | 株式会社日立製作所 | 光計測方法及び装置 |
US6580935B1 (en) * | 1999-03-12 | 2003-06-17 | Cirrex Corp. | Method and system for stabilizing reflected light |
US7430445B2 (en) * | 2003-04-24 | 2008-09-30 | The Board Of Regents Of The University Of Texas System | Noninvasive blood analysis by optical probing of the veins under the tongue |
US20050084980A1 (en) * | 2003-10-17 | 2005-04-21 | Intel Corporation | Method and device for detecting a small number of molecules using surface-enhanced coherant anti-stokes raman spectroscopy |
US7414729B2 (en) * | 2005-10-13 | 2008-08-19 | President And Fellows Of Harvard College | System and method for coherent anti-Stokes Raman scattering endoscopy |
JP2008289437A (ja) * | 2007-05-28 | 2008-12-04 | Sony Corp | レーザーを用いた酵素活性測定方法及び酵素活性測定装置 |
KR100973149B1 (ko) * | 2008-09-05 | 2010-07-30 | 한국표준과학연구원 | 분광엔코딩 방법을 적용한 간섭성 반스톡스 라만산란 내시경 |
-
2008
- 2008-06-26 JP JP2008166731A patent/JP4618341B2/ja not_active Expired - Fee Related
-
2009
- 2009-06-17 US US12/486,290 patent/US20090324498A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006524091A (ja) * | 2003-04-24 | 2006-10-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | カテーテルヘッド |
JP2007509322A (ja) * | 2003-10-17 | 2007-04-12 | インテル・コーポレーション | 表面増感コヒーレント反ストークスラマン分光を用いた少数の分子を検出する方法および装置 |
JP2007525662A (ja) * | 2003-12-30 | 2007-09-06 | インテル・コーポレーション | ラマン分光法を使用して生物試料のタンパク質プロファイルを得る方法 |
JP2007175242A (ja) * | 2005-12-27 | 2007-07-12 | Sharp Corp | 測定装置、測定プログラム及びコンピュータ読み取り可能な記録媒体 |
JP2007278768A (ja) * | 2006-04-04 | 2007-10-25 | Toshiba Corp | 顕微鏡装置 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013088746A1 (ja) | 2011-12-16 | 2013-06-20 | 独立行政法人理化学研究所 | レーザー走査型生体内特定物質量計測方法 |
JP2013126443A (ja) * | 2011-12-16 | 2013-06-27 | Institute Of Physical & Chemical Research | レーザー走査型生体内特定物質量計測方法 |
JP2017203646A (ja) * | 2016-05-09 | 2017-11-16 | 株式会社エーティーエー | 周波数変調cars計測装置 |
Also Published As
Publication number | Publication date |
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US20090324498A1 (en) | 2009-12-31 |
JP4618341B2 (ja) | 2011-01-26 |
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