JP2009539351A5 - - Google Patents
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- JP2009539351A5 JP2009539351A5 JP2009513478A JP2009513478A JP2009539351A5 JP 2009539351 A5 JP2009539351 A5 JP 2009539351A5 JP 2009513478 A JP2009513478 A JP 2009513478A JP 2009513478 A JP2009513478 A JP 2009513478A JP 2009539351 A5 JP2009539351 A5 JP 2009539351A5
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- Japan
- Prior art keywords
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- 238000000034 method Methods 0.000 claims description 144
- 102000004169 proteins and genes Human genes 0.000 claims description 114
- 108090000623 proteins and genes Proteins 0.000 claims description 114
- 235000018102 proteins Nutrition 0.000 claims description 82
- 102000035118 modified proteins Human genes 0.000 claims description 22
- 108091005573 modified proteins Proteins 0.000 claims description 22
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 19
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 19
- 239000005090 green fluorescent protein Substances 0.000 claims description 19
- 102000040430 polynucleotide Human genes 0.000 claims description 17
- 108091033319 polynucleotide Proteins 0.000 claims description 17
- 239000002157 polynucleotide Substances 0.000 claims description 17
- 125000000539 amino acid group Chemical group 0.000 claims description 16
- 150000001413 amino acids Chemical group 0.000 claims description 14
- 108010090804 Streptavidin Proteins 0.000 claims description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004472 Lysine Substances 0.000 claims description 6
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 235000018977 lysine Nutrition 0.000 claims description 6
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 4
- 235000009697 arginine Nutrition 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- 235000003704 aspartic acid Nutrition 0.000 claims description 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 4
- 235000013922 glutamic acid Nutrition 0.000 claims description 4
- 239000004220 glutamic acid Substances 0.000 claims description 4
- 235000014304 histidine Nutrition 0.000 claims description 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 4
- 230000005661 hydrophobic surface Effects 0.000 claims description 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 4
- 102000005720 Glutathione transferase Human genes 0.000 claims description 3
- 108010070675 Glutathione transferase Proteins 0.000 claims description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 108050001049 Extracellular proteins Proteins 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 101710172711 Structural protein Proteins 0.000 claims description 2
- 102000040945 Transcription factor Human genes 0.000 claims description 2
- 108091023040 Transcription factor Proteins 0.000 claims description 2
- 238000005094 computer simulation Methods 0.000 claims description 2
- 102000034287 fluorescent proteins Human genes 0.000 claims description 2
- 108091006047 fluorescent proteins Proteins 0.000 claims description 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
- 230000005660 hydrophilic surface Effects 0.000 claims description 2
- 231100000350 mutagenesis Toxicity 0.000 claims description 2
- 238000002741 site-directed mutagenesis Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 230000004845 protein aggregation Effects 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81036406P | 2006-06-02 | 2006-06-02 | |
| US60/810,364 | 2006-06-02 | ||
| PCT/US2007/070254 WO2007143574A1 (en) | 2006-06-02 | 2007-06-01 | Protein surface remodeling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004389A Division JP2013063093A (ja) | 2006-06-02 | 2013-01-15 | タンパク質表面のリモデリング |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009539351A JP2009539351A (ja) | 2009-11-19 |
| JP2009539351A5 true JP2009539351A5 (https=) | 2011-07-14 |
| JP5396270B2 JP5396270B2 (ja) | 2014-01-22 |
Family
ID=40892102
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513478A Expired - Fee Related JP5396270B2 (ja) | 2006-06-02 | 2007-06-01 | タンパク質表面のリモデリング |
| JP2013004389A Pending JP2013063093A (ja) | 2006-06-02 | 2013-01-15 | タンパク質表面のリモデリング |
| JP2014232389A Pending JP2015033392A (ja) | 2006-06-02 | 2014-11-17 | タンパク質表面のリモデリング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004389A Pending JP2013063093A (ja) | 2006-06-02 | 2013-01-15 | タンパク質表面のリモデリング |
| JP2014232389A Pending JP2015033392A (ja) | 2006-06-02 | 2014-11-17 | タンパク質表面のリモデリング |
Country Status (2)
| Country | Link |
|---|---|
| JP (3) | JP5396270B2 (https=) |
| CN (1) | CN101490548A (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104678092B (zh) * | 2015-01-28 | 2017-06-06 | 山东大学 | 高正电荷荧光蛋白在糖胺聚糖分析检测中的应用 |
| CN109752557B (zh) * | 2017-11-06 | 2021-06-08 | 清华大学 | 检测生物分子间相互作用及其调控因子的成套试剂与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK316989D0 (da) * | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
| ATE448306T1 (de) * | 2000-09-01 | 2009-11-15 | Blood Res Center | Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung |
| US7311701B2 (en) * | 2003-06-10 | 2007-12-25 | Cierra, Inc. | Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound |
| DE10342670A1 (de) * | 2003-09-16 | 2005-04-21 | Bayer Healthcare Ag | Isoliertes Photoprotein mtClytin, sowie dessen Verwendung |
| CN102250861A (zh) * | 2004-02-13 | 2011-11-23 | 诺维信公司 | 蛋白酶变体 |
-
2007
- 2007-06-01 JP JP2009513478A patent/JP5396270B2/ja not_active Expired - Fee Related
- 2007-06-01 CN CNA2007800271393A patent/CN101490548A/zh active Pending
-
2013
- 2013-01-15 JP JP2013004389A patent/JP2013063093A/ja active Pending
-
2014
- 2014-11-17 JP JP2014232389A patent/JP2015033392A/ja active Pending
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