JP2009535387A - Ｐｉ３キナーゼ阻害剤としてのチアゾール誘導体 - Google Patents
Ｐｉ３キナーゼ阻害剤としてのチアゾール誘導体 Download PDFInfo
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- JP2009535387A JP2009535387A JP2009508458A JP2009508458A JP2009535387A JP 2009535387 A JP2009535387 A JP 2009535387A JP 2009508458 A JP2009508458 A JP 2009508458A JP 2009508458 A JP2009508458 A JP 2009508458A JP 2009535387 A JP2009535387 A JP 2009535387A
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- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title description 2
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 22
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
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- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 3
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- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims description 3
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- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
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- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 2
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- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 50
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Classifications
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
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- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0608823.1A GB0608823D0 (en) | 2006-05-04 | 2006-05-04 | Inhibitors of P13 kinase |
| PCT/GB2007/001613 WO2007129048A1 (en) | 2006-05-04 | 2007-05-03 | Thiazole derivatives as inhibitors of p13 kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009535387A true JP2009535387A (ja) | 2009-10-01 |
| JP2009535387A5 JP2009535387A5 (enExample) | 2010-06-17 |
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| JP2009508458A Withdrawn JP2009535387A (ja) | 2006-05-04 | 2007-05-03 | Ｐｉ３キナーゼ阻害剤としてのチアゾール誘導体 |
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| Country | Link |
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| US (1) | US20100010057A1 (enExample) |
| EP (1) | EP2016063A1 (enExample) |
| JP (1) | JP2009535387A (enExample) |
| GB (1) | GB0608823D0 (enExample) |
| WO (1) | WO2007129048A1 (enExample) |
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| CA2668070A1 (en) * | 2006-10-30 | 2008-05-08 | Chroma Therapeutics Ltd. | Hydroxamates as inhibitors of histone deacetylase |
| GB0803747D0 (en) | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
| WO2009132310A1 (en) * | 2008-04-25 | 2009-10-29 | Wisconsin Alumni Research Foundation | Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth |
| CA2738868C (en) | 2008-10-01 | 2017-01-17 | Novartis Ag | Smoothened antagonism for the treatment of hedgehog pathway-related disorders |
| GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
| EP2763532B1 (en) * | 2011-10-05 | 2018-09-19 | The Board of Trustees of the Leland Stanford Junior University | Pi-kinase inhibitors with broad spectrum anti-infective activity |
| US9926309B2 (en) | 2011-10-05 | 2018-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Pi-kinase inhibitors with anti-infective activity |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| SI3222616T1 (sl) | 2012-10-17 | 2019-10-30 | Macrophage Pharma Ltd | N-(2-(4-(6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2H)-IL)-3,5- difluorofenil)etil)-L-alanin in njegov terbutil ester |
| ES3010661T3 (en) | 2016-02-26 | 2025-04-04 | Univ Leland Stanford Junior | Pi-kinase inhibitors with anti-infective activity |
| US10080757B2 (en) | 2016-03-11 | 2018-09-25 | Wisconsin Alumni Research Foundation | Inhibitors of UDP-galactopyranose mutase |
| GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
| CA3134417A1 (en) | 2019-03-21 | 2020-09-24 | The Board Of Trustees Of The Leland Stanford Junior University | Pi4-kinase inhibitors and methods of using the same |
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| AR038703A1 (es) * | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| GB0320197D0 (en) * | 2003-08-28 | 2003-10-01 | Novartis Ag | Organic compounds |
| MX2007013257A (es) * | 2005-05-05 | 2008-01-21 | Chroma Therapeutics Ltd | Conjugados de ester de alfa-aminoacido-farmaco hidrolizables por carboxilesterasa. |
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2006
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2007
- 2007-05-03 JP JP2009508458A patent/JP2009535387A/ja not_active Withdrawn
- 2007-05-03 US US12/299,495 patent/US20100010057A1/en not_active Abandoned
- 2007-05-03 WO PCT/GB2007/001613 patent/WO2007129048A1/en not_active Ceased
- 2007-05-03 EP EP07732646A patent/EP2016063A1/en not_active Withdrawn
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| US20100010057A1 (en) | 2010-01-14 |
| EP2016063A1 (en) | 2009-01-21 |
| WO2007129048A1 (en) | 2007-11-15 |
| GB0608823D0 (en) | 2006-06-14 |
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