JP2009534457A5 - - Google Patents
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- Publication number
- JP2009534457A5 JP2009534457A5 JP2009507165A JP2009507165A JP2009534457A5 JP 2009534457 A5 JP2009534457 A5 JP 2009534457A5 JP 2009507165 A JP2009507165 A JP 2009507165A JP 2009507165 A JP2009507165 A JP 2009507165A JP 2009534457 A5 JP2009534457 A5 JP 2009534457A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- compound according
- och
- ome
- nme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 32
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 17
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 11
- -1 -OH Chemical group 0.000 claims 10
- 125000003226 pyrazolyl group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000002098 pyridazinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000002785 azepinyl group Chemical group 0.000 claims 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 0 Cc1c(*)c(*)n[n]1* Chemical compound Cc1c(*)c(*)n[n]1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74563306P | 2006-04-26 | 2006-04-26 | |
| GBGB0608268.9A GB0608268D0 (en) | 2006-04-26 | 2006-04-26 | Therapeutic compounds |
| PCT/GB2007/001534 WO2007125330A1 (en) | 2006-04-26 | 2007-04-26 | Imidazo[4, 5-b]pyridin-2-one and oxazolo[4, 5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009534457A JP2009534457A (ja) | 2009-09-24 |
| JP2009534457A5 true JP2009534457A5 (cg-RX-API-DMAC10.html) | 2010-06-03 |
Family
ID=38421488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507165A Pending JP2009534457A (ja) | 2006-04-26 | 2007-04-26 | がん治療用化合物としてのイミダゾ［４，５−ｂ］ピリジン−２−オンおよびオキサゾロ［４，５−ｂ］ピリジン−２−オン化合物およびその類似体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7951819B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2013207B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2009534457A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007245495A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2649994A1 (cg-RX-API-DMAC10.html) |
| NO (1) | NO20084688L (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007125330A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110158944A1 (en) * | 2007-11-30 | 2011-06-30 | Hosted Thomas J | Braf biomarkers |
| NZ586418A (en) | 2007-12-19 | 2012-09-28 | Cancer Rec Tech Ltd | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| GB0807609D0 (en) * | 2008-04-25 | 2008-06-04 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US9229008B2 (en) | 2008-08-19 | 2016-01-05 | Merck Sharp & Dohme Corp. | IL-8 level as a determinant of responsivity of a cancer to treatment |
| WO2011021678A1 (ja) * | 2009-08-21 | 2011-02-24 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| DK2531502T3 (da) * | 2010-02-01 | 2014-05-19 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi |
| AU2011242697B2 (en) | 2010-04-21 | 2015-01-22 | Government Of The United States | Fluoroscopy-independent, endovascular aortic occlusion system |
| ES2699965T3 (es) | 2011-03-10 | 2019-02-13 | Provectus Pharmatech Inc | Una combinación de rosa de bengala y anticuerpo anti-CTLA4 para su uso en el tratamiento del cáncer |
| EP2739143B1 (en) * | 2011-08-05 | 2018-07-11 | Gary A. Flynn | Preparation and methods of use for ortho-aryl 5- membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors |
| US9474882B2 (en) | 2013-02-26 | 2016-10-25 | Prytime Medical Devices, Inc. | Fluoroscopy-independent balloon guided occlusion catheter and methods |
| WO2015035393A1 (en) | 2013-09-09 | 2015-03-12 | Pryor Medical Devices, Inc. | Low-profile occlusion catheter |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US10232142B2 (en) | 2014-06-10 | 2019-03-19 | Prytime Medical Devices, Inc. | Conduit guiding tip |
| AU2016232781B2 (en) | 2015-03-19 | 2017-11-02 | Prytime Medical Devices, Inc. | System for low-profile occlusion balloon catheter |
| CA2990479C (en) | 2016-06-02 | 2019-03-26 | Prytime Medical Devices, Inc. | System and method for low-profile occlusion balloon catheter |
| AU2017312970B2 (en) | 2016-08-16 | 2021-08-12 | Merck Patent Gmbh | 2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof |
| WO2018132623A1 (en) | 2017-01-12 | 2018-07-19 | The Regents Of The University Of California | Endovascular perfusion augmentation for critical care |
| CN117105827A (zh) | 2017-03-27 | 2023-11-24 | 魁北克电力公司 | 用于电解质组合物中或用作电极添加剂的盐 |
| CA3060519A1 (en) | 2017-04-21 | 2018-10-25 | The Regents Of The University Of California | Aortic flow meter and pump for partial-aortic occlusion |
| CN118903436A (zh) | 2018-01-31 | 2024-11-08 | 德西费拉制药有限责任公司 | 治疗肥大细胞增多症的组合疗法 |
| KR102708177B1 (ko) | 2018-01-31 | 2024-09-23 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양의 치료를 위한 병용 요법 |
| WO2020033372A1 (en) | 2018-08-06 | 2020-02-13 | Prytime Medical Devices, Inc. | System and method for low profile occlusion balloon catheter |
| IL330104A (en) | 2019-03-11 | 2026-08-01 | Deciphera Pharmaceuticals Llc | Crystalline forms of rifatinib |
| PL4010330T3 (pl) | 2019-08-08 | 2026-03-16 | Hirundo Biosciences | Pochodne chinoliny jako inhibitory kinazy białkowej |
| US12691108B2 (en) | 2019-08-12 | 2026-07-28 | Deciphera Pharmaceuticals, Llc | Methods for treating vascular malformations |
| HRP20260411T1 (hr) | 2019-08-12 | 2026-05-08 | Deciphera Pharmaceuticals, Llc | Ripretinib za liječenje gastrointestinalnih stromalnih tumora |
| WO2021057696A1 (zh) * | 2019-09-27 | 2021-04-01 | 隆泰申医药科技(南京)有限公司 | 一种杂芳基类化合物及其应用 |
| FI4084779T3 (fi) | 2019-12-30 | 2024-12-16 | Deciphera Pharmaceuticals Llc | 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia |
| WO2021188602A2 (en) | 2020-03-16 | 2021-09-23 | Certus Critical Care, Inc. | Blood flow control devices, systems, and methods and error detection thereof |
| US11629143B2 (en) | 2020-10-01 | 2023-04-18 | Vibliome Therapeutics, Llc | HipK4 inhibitors and uses thereof |
| US12102330B2 (en) | 2021-03-18 | 2024-10-01 | Prytime Medical Devices, Inc. | Vascular occlusion catheter for partial occlusion or full occlusion |
| TWI812301B (zh) * | 2021-06-24 | 2023-08-11 | 南韓商Ｌｇ化學股份有限公司 | 作為ｒｏｎ抑制劑之新穎尿素衍生物化合物 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| CN120239701A (zh) | 2022-11-24 | 2025-07-01 | Bci制药公司 | 作为蛋白激酶抑制剂的吡啶衍生物 |
| EP4750767A1 (en) | 2023-07-26 | 2026-06-03 | Hirundo Biosciences | Quinazolinone, benzoxazinone and benzoxazepinone derivatives as protein kinase inhibitors |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5665863A (en) | 1979-10-31 | 1981-06-03 | Tokyo Organ Chem Ind Ltd | Novel aniline derivative, its preparation and pesticide containing the same |
| JPS5738777A (en) | 1980-08-19 | 1982-03-03 | Sogo Yatsukou Kk | 2-sufanilamidopyrathyn derivative |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5879672A (en) | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
| EP0783572B1 (en) | 1994-09-22 | 2005-04-27 | Licentia Ltd. | Promoter for the receptor tyrosine kinase, tie |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| ZA971896B (en) | 1996-03-26 | 1998-09-07 | Du Pont Merck Pharma | Aryloxy-and arythio-fused pyridines and pyrimidines and derivatives |
| CA2744096C (en) | 1996-07-31 | 2013-07-30 | Laboratory Corporation Of America Holdings | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| US6030831A (en) | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
| RU2230553C2 (ru) | 1997-09-26 | 2004-06-20 | Центарис АГ | Способ модулирования функции серин/треонин протеинкиназы соединением на основе азабензимидазола, способ идентификации соединений, модулирующих функцию серин/треонин протеинкиназы, способ профилактики или лечения патологических состояний в организме, соединение на основе азабензимидазола, способ его синтеза и фармацевтическая композиция |
| GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| GB2356398A (en) | 1999-11-18 | 2001-05-23 | Lilly Dev Ct S A | Preparation of arylsulfamides |
| US6610688B2 (en) | 1999-12-21 | 2003-08-26 | Sugen, Inc. | 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
| US6492529B1 (en) | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| US7238813B2 (en) | 2000-11-29 | 2007-07-03 | Smithkline Beecham Corporation | Chemical compounds |
| EP1456364B1 (en) | 2001-12-21 | 2011-03-23 | The Wellcome Trust | Mutations in the b-raf gene |
| JP4335136B2 (ja) | 2002-08-09 | 2009-09-30 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害薬 |
| TW200616974A (en) | 2004-07-01 | 2006-06-01 | Astrazeneca Ab | Chemical compounds |
| US20090118261A1 (en) | 2004-08-31 | 2009-05-07 | Astrazeneca Ab | Quinazolinone derivatives and their use as b-raf inhibitors |
| GB0423554D0 (en) | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
-
2007
- 2007-04-26 EP EP07732571A patent/EP2013207B1/en active Active
- 2007-04-26 AU AU2007245495A patent/AU2007245495A1/en not_active Abandoned
- 2007-04-26 WO PCT/GB2007/001534 patent/WO2007125330A1/en not_active Ceased
- 2007-04-26 JP JP2009507165A patent/JP2009534457A/ja active Pending
- 2007-04-26 CA CA002649994A patent/CA2649994A1/en not_active Abandoned
- 2007-04-26 US US12/298,325 patent/US7951819B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 NO NO20084688A patent/NO20084688L/no not_active Application Discontinuation