JP2009533417A5 - - Google Patents
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- Publication number
- JP2009533417A5 JP2009533417A5 JP2009504857A JP2009504857A JP2009533417A5 JP 2009533417 A5 JP2009533417 A5 JP 2009533417A5 JP 2009504857 A JP2009504857 A JP 2009504857A JP 2009504857 A JP2009504857 A JP 2009504857A JP 2009533417 A5 JP2009533417 A5 JP 2009533417A5
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- JP
- Japan
- Prior art keywords
- formula
- derivative
- group
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052799 carbon Inorganic materials 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000001721 carbon Chemical group 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000011737 fluorine Substances 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 239000002841 Lewis acid Substances 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000003636 chemical group Chemical group 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000007517 lewis acids Chemical class 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- -1 phenol compound Chemical class 0.000 claims 2
- 150000002989 phenols Chemical class 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000000376 reactant Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 241000590002 Helicobacter pylori Species 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 244000000010 microbial pathogen Species 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 0 *c(c(*)c1O*)c(*)c(*)c1O* Chemical compound *c(c(*)c1O*)c(*)c(*)c1O* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20060290611 EP1845087A1 (en) | 2006-04-14 | 2006-04-14 | Hydroxyphenyl derivatives and biological applications thereof |
| EP06290611.0 | 2006-04-14 | ||
| PCT/IB2007/002127 WO2007135562A2 (en) | 2006-04-14 | 2007-04-16 | Hydroxyphenyl derivatives and biological applications thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009533417A JP2009533417A (ja) | 2009-09-17 |
| JP2009533417A5 true JP2009533417A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2010-05-27 |
| JP5579432B2 JP5579432B2 (ja) | 2014-08-27 |
Family
ID=37007447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009504857A Expired - Fee Related JP5579432B2 (ja) | 2006-04-14 | 2007-04-16 | 新規ヒドロキシフェニル誘導体およびその生物学的適用 |
Country Status (8)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1845087A1 (en) | 2006-04-14 | 2007-10-17 | Mutabilis SA | Hydroxyphenyl derivatives and biological applications thereof |
| DE102008053242A1 (de) * | 2008-10-25 | 2010-05-06 | Saltigo Gmbh | Heteroaryl-Arylether |
| BR112012004587A2 (pt) * | 2009-09-01 | 2016-04-05 | Fab Pharma Sas | composto antibacteriano de hidroxifenila |
| EP2491021B1 (en) | 2009-10-20 | 2014-04-23 | FAB Pharma SAS | Novel acylpiperazinones and their use as pharmaceuticals |
| US8846711B2 (en) | 2009-11-18 | 2014-09-30 | Fab Pharma S.A.S. | Heterocyclic acrylamides and their use as pharmaceuticals |
| EP2539305B1 (en) * | 2010-02-27 | 2017-02-15 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Chrysophaentin antimicrobial compounds that inhibit ftsz protein |
| EP2474313A1 (en) * | 2011-01-11 | 2012-07-11 | ABRA Pharmaceuticals sàrl | Novel self-assembling polyphenol-quinonoid polymer derivatives and use thereof |
| GB201522179D0 (en) * | 2015-12-16 | 2016-01-27 | Autifony Therapeutics Ltd | Novel compounds |
| HRP20231228T1 (hr) | 2018-08-09 | 2024-01-19 | Antabio Sas | Diazabiciklooktanoni kao inhibitori serinskih beta-laktamaza |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3391195A (en) * | 1963-12-04 | 1968-07-02 | Monsanto Res Corp | Fluorinated polyphenyl ethers |
| CH477165A (de) * | 1967-08-01 | 1969-08-31 | Geigy Ag J R | Verfahren zum antimikrobiellen Ausrüsten bzw. zum Schützen von Textilien gegen den Befall durch Mikroorganismen und eine Flotte bzw. ein Bad zur Durchführung dieses Verfahrens |
| GB1390616A (en) * | 1971-07-27 | 1975-04-16 | Ciba Geigy Ag | Antibacterial compositions |
| US5578295A (en) * | 1995-04-28 | 1996-11-26 | The Procter & Gamble Company | Oral care compositions comprising certain substituted diphenyl ethers |
| EP1042265A2 (en) * | 1997-12-12 | 2000-10-11 | Ciba SC Holding AG | O-derivatives of halogenated diphenyl ether compounds |
| GB9827391D0 (en) * | 1998-12-11 | 1999-02-03 | Fundation O N C F | Aldose reductase inhibitors and pharmaceutical compositions |
| DE10015525A1 (de) * | 2000-03-30 | 2001-10-11 | Deutsches Krebsforsch | Synthetische Derivate von Lunularsäure, Arzneimittel enthaltend diese Verbindung, Verfahren zur Herstellung der Lunularsäurederivate sowie deren Verwendung |
| CN1662238A (zh) * | 2002-04-18 | 2005-08-31 | 塞米得肿瘤学美国公司 | 肽去甲酰酶活化的前体药物 |
| FR2839448A1 (fr) * | 2002-05-07 | 2003-11-14 | Oreal | Utilisation d'esters de triclosan, de piroctone et de tropolone dans une composition a liberation controlee |
| AU2003290779A1 (en) * | 2002-11-14 | 2004-06-03 | Celmed Oncology (Usa), Inc. | Peptide deformylase activated prodrugs |
| WO2006018723A2 (en) | 2004-08-18 | 2006-02-23 | Warner-Lambert Company Llc | Androgen modulators |
| US7687547B2 (en) | 2004-08-23 | 2010-03-30 | Research Foundation Of State University Of New York | Diphenyl ether antimicrobial compounds |
| US20060211697A1 (en) * | 2004-12-08 | 2006-09-21 | Liren Huang | 2-(2 Or 4-substituted aryloxy)-phenol derivatives as antibacterial agents |
| US20070054884A1 (en) | 2005-08-31 | 2007-03-08 | Emergent Product Development Gaithersburg Inc. | 4-substituted 2-aryloxyphenol derivatives as antibacterial agents |
| EP1845087A1 (en) * | 2006-04-14 | 2007-10-17 | Mutabilis SA | Hydroxyphenyl derivatives and biological applications thereof |
| BR112012004587A2 (pt) * | 2009-09-01 | 2016-04-05 | Fab Pharma Sas | composto antibacteriano de hidroxifenila |
-
2006
- 2006-04-14 EP EP20060290611 patent/EP1845087A1/en not_active Withdrawn
-
2007
- 2007-04-16 CA CA2649196A patent/CA2649196C/en not_active Expired - Fee Related
- 2007-04-16 EP EP07789559A patent/EP2010495A2/en not_active Withdrawn
- 2007-04-16 CN CN200780022244.8A patent/CN101500999B/zh not_active Expired - Fee Related
- 2007-04-16 US US12/226,281 patent/US8722746B2/en not_active Expired - Fee Related
- 2007-04-16 WO PCT/IB2007/002127 patent/WO2007135562A2/en active Application Filing
- 2007-04-16 AU AU2007252917A patent/AU2007252917C1/en not_active Ceased
- 2007-04-16 JP JP2009504857A patent/JP5579432B2/ja not_active Expired - Fee Related
-
2008
- 2008-10-22 IL IL194781A patent/IL194781A/en not_active IP Right Cessation
-
2014
- 2014-03-28 US US14/228,893 patent/US9309179B2/en not_active Expired - Fee Related
-
2016
- 2016-03-08 US US15/063,891 patent/US20160185724A1/en not_active Abandoned