JP2009528431A - 抗菌剤放出ポリマー - Google Patents
抗菌剤放出ポリマー Download PDFInfo
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Abstract
Description
本願は、2006年2月28日に出願された米国仮特許出願第60/777,430号の利益および優先権を主張する。米国仮特許出願第60/777,430号は、本明細書中に参考として援用される。
本発明の開示は、医療デバイス、またはそのデバイス上のコーティングを形成するのに好適なポリマーに関する。より詳しくは、本発明の開示は、in vivoで抗菌剤のような生物活性剤を放出できるポリマーに関する。
合成ポリマー材料を含む生分解材料は、様々な用途、とりわけ医療目的で生分解材料が生体内に埋め込まれる用途が当業者に知られている。「生分解」という用語は、通常、生体による代謝および/または排出が可能な小さな構成物質にまで分解できる材料を言い表している。加水分解は、生体内に埋め込まれた後、多くの生分解材料が分解される1つの機構である。加水分解的に不安定なため生分解性である合成ポリマーは、1つ以上のグリコリド、ラクチド、p‐ジオキサノン、ε‐カプロラクトンおよび/またはトリメチレンカーボネートから得られたポリマーである。そのような材料から作られた医療デバイス(例えば、縫合糸、留め具、ピンなど)は、治療中組織を所望の位置で一時的に留めておき、一定時間後生体内に吸収されるのに役立ちうる。
本発明の開示は、医療デバイスを形成するのに役立ちうる生物活性ポリマーを提供する。生物活性ポリマーは、生分解性ポリマーの主鎖に組み込まれた、またはペンダント型結合によってポリマーに付加された少なくとも1つのヒドロキシル基含有生物活性剤を含む。ヒドロキシル基含有抗菌剤のような、ヒドロキシル基含有生物活性剤は、生分解性ポリマーとして放出されるか、またはペンダント型結合がin vivoで分解する。いくつかの実施形態において、トリクロサンは生物活性ポリマーを形成するのに用いられる抗菌剤である。
本明細書中で説明されるポリマーは、ポリマーに結合した、少なくとも1つのヒドロキシル基含有生物活性剤を有し、該生物活性剤はポリマーの加水分解によりin vivoで放出される。本明細書で用いられているように、「生物活性ポリマー」は、ポリマーに結合した、少なくとも1つのヒドロキシル基含有生物活性剤を有するポリマーである。本明細書で用いられているように、「生物活性剤」および「ヒドロキシル基含有生物活性剤」は、in vivoでの生物活性、および生物活性剤を生物活性ポリマーに結び付けることができる少なくとも1つのヒドロキシル基を有する化合物を言い表すのに交互に用いられている。いくつかの実施形態においては、生物活性剤はポリマーの主鎖に組み込まれてもよい。その場合、in vivoでのポリマーの分解によって生物活性剤を放出できる生活性ポリマーであると有利である。他の実施形態では、生物活性剤は生分解性ペンダント型結合を通してポリマーに結び付けられてもよい。ペンダント型結合はin vivoで分解し、それによってポリマーから生物活性剤を放出する。
Claims (22)
- 生分解性ポリマーの主鎖に組み込まれた少なくとも1つのヒドロキシル基含有生物活性剤を含む、生物活性ポリマーであって、
前記生分解性ポリマーがin vivoで分解するときに抗菌剤が放出される、生物活性ポリマー。 - 前記生分解性ポリマーの主鎖は、グリコリド、グリコール酸、ラクチド、乳酸、カプロラクトン、ジオキサノン、トリメチレンカーボネート、ジメチルトリメチレンカーボネート、これらの共重合体、およびこれらの組み合わせからなる群から選択される少なくとも1つのモノマーである、請求項1に記載の生物活性ポリマー。
- 前記生分解性ポリマーの主鎖は、コラーゲン、キチン、キトサン、アミノ酸ポリマー、分解性ポリウレタン、ポリアルキレンオキシド開始ブロック共重合体、多糖類、およびこれらの組み合わせからなる群から選択される、請求項1に記載の生物活性ポリマー。
- 前記ヒドロキシル基含有生物活性剤は、p‐クロロ‐m‐キシレノール、トリクロサンおよびアルコールからなる群から選択される抗菌剤である、請求項1に記載の生物活性ポリマー。
- 前記抗菌剤はトリクロサンを含む、請求項1に記載の生物活性ポリマー。
- 請求項1に記載の生物活性ポリマーを含む、医療デバイス。
- 請求項1に記載の生物活性ポリマーを含む、手術器具。
- 請求項1に記載の生物活性ポリマーを含む、縫合糸。
- 請求項1に記載の生物活性ポリマーを含む組成物でコーティングされた、縫合糸。
- ポリマー主鎖と、
少なくとも1つのヒドロキシル基含有抗菌剤と、
前記少なくとも1つのヒドロキシル基含有抗菌剤を前記ポリマー主鎖に付加する生分解性結合と、
を含む生物活性ポリマーであって、
前記生分解性結合がin vivoで分解するときに、ヒドロキシル基含有抗菌剤が前記ポリマー主鎖から放出される、生物活性ポリマー。 - 前記ポリマー主鎖は生分解性ポリマーを含む、請求項10に記載の生物活性ポリマー。
- 前記ポリマー主鎖は、グリコリド、グリコール酸、ラクチド、乳酸、カプロラクトン、ジオキサノン、トリメチレンカーボネート、ジメチルトリメチレンカーボネート、これらの共重合体、およびこれらの組み合わせからなる群から選択される少なくとも1つのモノマーから少なくとも部分的に形成される、請求項10に記載の生物活性ポリマー。
- 前記ポリマー主鎖は、コラーゲン、キチン、キトサン、アミノ酸ポリマー、分解性ポリウレタン、ポリアルキレンオキシド開始ブロック共重合体、多糖類、およびこれらの組み合わせからなる群から選択される生分解性ポリマーを含む、請求項10に記載の生物活性ポリマー。
- 前記ポリマー主鎖は非吸収性ポリマーを含む、請求項10に記載の生物活性ポリマー。
- 前記ポリマー主鎖は、ポリエステル、ポリアミド、ポリウレタン、ポリカーボネート、ポリアミド、フッ素重合体、ポリオレフィン、ビニルポリマー、およびこれらの組み合わせからなる群から選択されるポリマーから少なくとも部分的に形成される、請求項10に記載の生物活性ポリマー。
- 前記ヒドロキシル基含有抗菌剤は、p‐クロロ‐m‐キシレノール、トリクロサン、およびアルコールからなる群から選択される、請求項10に記載の生物活性ポリマー。
- 前記ヒドロキシル基含有抗菌剤はトリクロサンを含む、請求項10に記載の生物活性ポリマー。
- 前記生分解性結合は、エーテル、エステル、ウレタン、およびアセタールからなる群から選択される、請求項10に記載の生物活性ポリマー。
- 請求項10に記載の生物活性ポリマーを含む、医療デバイス。
- 請求項10に記載の生物活性ポリマーを含む、縫合糸。
- 請求項10に記載の生物活性ポリマーを含む、手術器具。
- 請求項10に記載の生物活性ポリマーを含む組成物によってコーティングされた、縫合糸。
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US20070224162A1 (en) | 2007-09-27 |
US20110129512A1 (en) | 2011-06-02 |
AU2007221052A1 (en) | 2007-09-07 |
WO2007100883A3 (en) | 2008-12-04 |
AU2007221052B2 (en) | 2013-05-16 |
CA2638768A1 (en) | 2007-09-07 |
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WO2007100883A2 (en) | 2007-09-07 |
EP1991240A4 (en) | 2012-12-12 |
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