JP2009525044A5 - - Google Patents
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- JP2009525044A5 JP2009525044A5 JP2008553314A JP2008553314A JP2009525044A5 JP 2009525044 A5 JP2009525044 A5 JP 2009525044A5 JP 2008553314 A JP2008553314 A JP 2008553314A JP 2008553314 A JP2008553314 A JP 2008553314A JP 2009525044 A5 JP2009525044 A5 JP 2009525044A5
- Authority
- JP
- Japan
- Prior art keywords
- mesenchymal
- self
- organized
- asc
- assembled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 35
- 108010087999 Steryl-Sulfatase Proteins 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000001963 growth medium Substances 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 3
- 210000001789 adipocyte Anatomy 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 210000001612 chondrocyte Anatomy 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 210000000963 osteoblast Anatomy 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 102100021811 E3 ubiquitin-protein ligase RNF5 Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000728679 Homo sapiens Apoptosis-associated speck-like protein containing a CARD Proteins 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims 1
- 101001107084 Homo sapiens E3 ubiquitin-protein ligase RNF5 Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
- 101000661600 Homo sapiens Steryl-sulfatase Proteins 0.000 claims 1
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 claims 1
- 102000013013 Member 2 Subfamily G ATP Binding Cassette Transporter Human genes 0.000 claims 1
- 108010090306 Member 2 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 1
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 230000003915 cell function Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000002458 cell surface marker Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000050702 human PYCARD Human genes 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76333306P | 2006-01-30 | 2006-01-30 | |
| PCT/US2007/002572 WO2007089798A2 (en) | 2006-01-30 | 2007-01-30 | Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525044A JP2009525044A (ja) | 2009-07-09 |
| JP2009525044A5 true JP2009525044A5 (enExample) | 2010-07-15 |
Family
ID=38328013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553314A Pending JP2009525044A (ja) | 2006-01-30 | 2007-01-30 | 間葉系幹細胞集合体を調製および特性評価する方法ならびにそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8592209B2 (enExample) |
| EP (1) | EP1984488B1 (enExample) |
| JP (1) | JP2009525044A (enExample) |
| KR (1) | KR20080091832A (enExample) |
| AU (1) | AU2007209870A1 (enExample) |
| CA (1) | CA2641022A1 (enExample) |
| WO (1) | WO2007089798A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100322906A1 (en) | 2005-10-05 | 2010-12-23 | Osaka University | Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells |
| EP1984488B1 (en) | 2006-01-30 | 2017-12-27 | University Of Virginia Patent Foundation | Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof |
| US8835170B2 (en) | 2006-10-06 | 2014-09-16 | University Of Virginia Patent Foundation | Methods and compositions useful for diabetic wound healing |
| US10633632B2 (en) * | 2007-07-12 | 2020-04-28 | Discgenics, Inc. | Human disc tissue |
| US20120100607A1 (en) * | 2007-07-12 | 2012-04-26 | Christopher Duntsch | Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease |
| US8227246B2 (en) | 2007-07-12 | 2012-07-24 | Discgenics | Compositions of adult disc stem cells for the treatment of degenerative disc disease |
| US8017390B2 (en) | 2007-07-20 | 2011-09-13 | Dongguk University Industry-Academic Cooperation Foundation | Method for the preparation of dermal papilla tissue employing mesenchymal stem cells |
| CA2712496C (en) * | 2008-01-18 | 2021-01-12 | Wei-Shou Hu | Stem cell aggregates and methods for making and using |
| US20110059182A1 (en) * | 2008-02-05 | 2011-03-10 | University Of Virginia Patent Foundation | Spraying device and related method for cell aggregates and cell aggregate suspension thereof |
| US20110165128A1 (en) * | 2008-03-07 | 2011-07-07 | Columbia University In The City Of New York | Homing in mesenchymal stem cells |
| GB0805670D0 (en) * | 2008-03-28 | 2008-04-30 | Smith & Nephew | Increasing the plasticity of stem cells |
| AU2009281809B2 (en) * | 2008-08-14 | 2015-09-17 | Mesoblast International Sarl | Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions |
| JP5490803B2 (ja) * | 2008-09-22 | 2014-05-14 | ウニヴェルジテート チューリッヒ プロレクトラート エムエヌヴェー | 懸滴プレートおよび同懸滴プレートを使用する方法 |
| US20100112031A1 (en) * | 2008-10-17 | 2010-05-06 | University Of Virginia Patent Foundation | Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells |
| US20100098739A1 (en) * | 2008-10-20 | 2010-04-22 | University Of Virginia Patent Foundation | Compositions and methods for modular soft tissue repair |
| WO2010129775A1 (en) | 2009-05-06 | 2010-11-11 | University Of Virginia Patent Foundation | Self-illuminated handheld lens for retinal examination and photography and related method thereof |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| SG10201914007YA (en) | 2010-08-24 | 2020-03-30 | Univ Minnesota | Non-static suspension culture of cell aggregates |
| US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
| US9234177B2 (en) * | 2010-10-18 | 2016-01-12 | Sunshine Life Science & Technology Corp. | Human multipotent embryonic stem cell-like progenitor cells |
| EP2655602B1 (en) * | 2010-12-22 | 2019-01-23 | The Administrators of the Tulane Educational Fund | Method for identifcation and culture of multipotent mesenchymal stem cells with high proliferation potential |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| EP2765186A4 (en) * | 2011-05-31 | 2015-05-27 | Snu R&Db Foundation | STRUCTURE FOR TEXTILE GENERATION AND METHOD OF MANUFACTURING THEREOF |
| AU2012275335B2 (en) | 2011-06-29 | 2017-04-20 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
| CA2883374C (en) * | 2012-08-29 | 2016-03-22 | Euromi S.A. | Apparatus for extracting and re-injecting adipose tissue |
| AU2014253920B2 (en) | 2013-04-19 | 2019-07-04 | Biorestorative Therapies, Inc. | Human brown adipose derived stem cells and uses |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| SG11201707615YA (en) | 2013-09-19 | 2017-10-30 | Univ Leland Stanford Junior | Methods and compositions for producing hepatocyte-like cells |
| WO2015199416A1 (ko) * | 2014-06-23 | 2015-12-30 | 단국대학교 천안캠퍼스 산학협력단 | 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용 |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| EP3359553B1 (en) | 2015-10-06 | 2025-03-26 | University Of Virginia Patent Foundation | Compositions for treating diabetic retinopathy |
| US20210355199A1 (en) | 2018-06-28 | 2021-11-18 | University Of Virginia Patent Foundation | Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling |
| US11541101B1 (en) | 2018-10-09 | 2023-01-03 | University Of Virginia Patent Foundation | LEMD3 antagonizes TGF-beta-driven Smad2/3 transcription in a stiffness-dependent fashion in both the nucleus and cytosol |
| CN111518751A (zh) * | 2019-11-20 | 2020-08-11 | 广东先康达生物科技有限公司 | 一种体外激活脂肪干细胞转化成原软骨细胞的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| AU4543193A (en) * | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| DE69634303T2 (de) | 1995-11-16 | 2006-01-05 | Case Western Reserve University, Cleveland | Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| CN1352696A (zh) | 1999-03-10 | 2002-06-05 | 匹兹堡大学联邦制高等教育 | 脂肪来源的干细胞和网格 |
| US6429013B1 (en) * | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
| EP1261694B1 (en) * | 2000-02-26 | 2008-01-16 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
| DE10013223C2 (de) * | 2000-03-13 | 2002-07-18 | Co Don Ag | Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial |
| EP1496978A4 (en) | 2002-04-03 | 2006-11-29 | Artecel Sciences Inc | IMPROVEMENTS IN DIFFERENTIATED ADULT DIFFERENTIATED STEM CELLS DERIVED FROM ADIPOSE TISSUE AND USES THEREOF |
| JP2004150624A (ja) | 2002-09-03 | 2004-05-27 | Seiko Epson Corp | 磁気軸受装置 |
| KR100534215B1 (ko) | 2003-11-11 | 2005-12-08 | (주)히스토스템 | 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법 |
| JP4499041B2 (ja) * | 2003-12-11 | 2010-07-07 | 独立行政法人科学技術振興機構 | 擬微小重力環境下での骨髄細胞を用いた３次元軟骨組織構築方法 |
| WO2005114178A1 (de) | 2004-05-21 | 2005-12-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multizelluläre testsysteme |
| US20060045872A1 (en) * | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| WO2006032054A2 (en) | 2004-09-14 | 2006-03-23 | The Trustees Of Columbia University In The City Of New York | Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair |
| KR100833612B1 (ko) | 2004-12-29 | 2008-05-30 | 에프씨비파미셀 주식회사 | 간엽 간세포로부터 분화된 신경세포를 유효성분으로함유하는 신경계 질환 치료용 약학 조성물 |
| WO2006074075A2 (en) * | 2004-12-30 | 2006-07-13 | Primegen Biotech, Llc | Adipose-derived stem cells for tissue regeneration and wound healing |
| EP1909581A4 (en) | 2005-07-29 | 2008-12-31 | Univ Virginia | Adipose tissue stem cells, perivascular cells and pericytes |
| WO2007030652A2 (en) | 2005-09-08 | 2007-03-15 | University Of Virginia Patent Foundation | Methods and compositions for growing adipose stem cells |
| KR100679642B1 (ko) * | 2005-11-16 | 2007-02-06 | 주식회사 알앤엘바이오 | 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제 |
| EP1984488B1 (en) | 2006-01-30 | 2017-12-27 | University Of Virginia Patent Foundation | Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof |
| US8835170B2 (en) * | 2006-10-06 | 2014-09-16 | University Of Virginia Patent Foundation | Methods and compositions useful for diabetic wound healing |
| US7787327B2 (en) | 2006-11-15 | 2010-08-31 | Baker Hughes Incorporated | Cement bond analysis |
| US20100098739A1 (en) * | 2008-10-20 | 2010-04-22 | University Of Virginia Patent Foundation | Compositions and methods for modular soft tissue repair |
-
2007
- 2007-01-30 EP EP07762669.5A patent/EP1984488B1/en active Active
- 2007-01-30 WO PCT/US2007/002572 patent/WO2007089798A2/en not_active Ceased
- 2007-01-30 CA CA002641022A patent/CA2641022A1/en not_active Abandoned
- 2007-01-30 JP JP2008553314A patent/JP2009525044A/ja active Pending
- 2007-01-30 AU AU2007209870A patent/AU2007209870A1/en not_active Abandoned
- 2007-01-30 KR KR1020087021183A patent/KR20080091832A/ko not_active Withdrawn
- 2007-01-30 US US12/162,523 patent/US8592209B2/en active Active
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