JP2009522287A - 脂肪酸アミド加水分解酵素阻害剤 - Google Patents

脂肪酸アミド加水分解酵素阻害剤 Download PDF

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JP2009522287A
JP2009522287A JP2008548741A JP2008548741A JP2009522287A JP 2009522287 A JP2009522287 A JP 2009522287A JP 2008548741 A JP2008548741 A JP 2008548741A JP 2008548741 A JP2008548741 A JP 2008548741A JP 2009522287 A JP2009522287 A JP 2009522287A
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ダス，オリビエ
プツトマン，デイビツド
コンプトン，テイモシー・アール
パロツト，ジエフ
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ナームローゼ・フエンノートチヤツプ・オルガノン
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    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
JP2008548741A 2005-12-29 2006-12-28 脂肪酸アミド加水分解酵素阻害剤 Withdrawn JP2009522287A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US75503505P 2005-12-29 2005-12-29
US82287706P 2006-08-18 2006-08-18
US82307606P 2006-08-21 2006-08-21
US82488706P 2006-09-07 2006-09-07
US82786106P 2006-10-02 2006-10-02
US82875306P 2006-10-09 2006-10-09
US86656806P 2006-11-20 2006-11-20
US11/561,774 US20070155707A1 (en) 2005-12-29 2006-11-20 Ionizable inhibitors of fatty acid amide hydrolase
PCT/US2006/049485 WO2007079180A2 (fr) 2005-12-29 2006-12-28 Inhibiteurs de l’amide hydrolase d’acides gras

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JP2009522287A true JP2009522287A (ja) 2009-06-11

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JP2008548741A Withdrawn JP2009522287A (ja) 2005-12-29 2006-12-28 脂肪酸アミド加水分解酵素阻害剤

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EP (1) EP1969051A2 (fr)
JP (1) JP2009522287A (fr)
KR (1) KR20080091132A (fr)
AU (1) AU2006332675A1 (fr)
CA (1) CA2635232A1 (fr)
IL (1) IL191819A0 (fr)
MX (1) MX2008008529A (fr)
WO (1) WO2007079180A2 (fr)

Cited By (1)

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JP2015525788A (ja) * 2012-08-06 2015-09-07 フォンダツィオーネ・イスティトゥート・イタリアーノ・ディ・テクノロジャＦｏｎｄａｚｉｏｎｅ Ｉｓｔｉｔｕｔｏ Ｉｔａｌｉａｎｏ Ｄｉ Ｔｅｃｎｏｌｏｇｉａ マルチターゲットｆａａｈおよびｃｏｘインヒビターならびにその治療上の用途

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US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
WO2008042892A2 (fr) * 2006-10-02 2008-04-10 N.V. Organon Procédé de traitement de troubles du métabolisme énergétique en empêchant l'activité d'un amide hydrolase d'acide gras
AP2780A (en) 2006-10-18 2013-09-30 Pfizer Prod Inc Biaryl ether urea compounds
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
WO2012058115A2 (fr) 2010-10-28 2012-05-03 Benjamin Cravatt Carbamates inhibiteurs de sérine hydrolases pour lutter contre le cancer
ITMI20131180A1 (it) * 2013-07-15 2015-01-16 Fond Istituto Italiano Di Tecnologia O-alchil triazolil carbammati come inibitori di idrolasi delle ammidi degli acidi grassi (faah)
CN117777121A (zh) 2016-10-24 2024-03-29 詹森药业有限公司 化合物及其用途
EP3700934A4 (fr) 2017-10-24 2021-10-27 Yumanity Therapeutics, Inc. Composés et utilisations de ces composés

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80841C2 (en) * 2002-10-07 2007-11-12 Univ California Fatty acid amide hydrolase inhibitors, pharmaceutical composition (variants) and method to treat appetite disorders, glaucoma, pain, and related neurological disorders (variants)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015525788A (ja) * 2012-08-06 2015-09-07 フォンダツィオーネ・イスティトゥート・イタリアーノ・ディ・テクノロジャＦｏｎｄａｚｉｏｎｅ Ｉｓｔｉｔｕｔｏ Ｉｔａｌｉａｎｏ Ｄｉ Ｔｅｃｎｏｌｏｇｉａ マルチターゲットｆａａｈおよびｃｏｘインヒビターならびにその治療上の用途

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KR20080091132A (ko) 2008-10-09
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