JP2009521512A5 - - Google Patents

Info

Publication number

JP2009521512A5

JP2009521512A5 JP2008547791A JP2008547791A JP2009521512A5 JP 2009521512 A5 JP2009521512 A5 JP 2009521512A5 JP 2008547791 A JP2008547791 A JP 2008547791A JP 2008547791 A JP2008547791 A JP 2008547791A JP 2009521512 A5 JP2009521512 A5 JP 2009521512A5

Authority

JP

Japan

Prior art keywords

composition

targeting peptide

subject

endometriosis

amino acid

Prior art date

2006-12-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 71
• 230000008685 targeting Effects 0.000 claims 33
• 108090000765 processed proteins & peptides Proteins 0.000 claims 32
• 201000009273 Endometriosis Diseases 0.000 claims 19
• 239000012636 effector Substances 0.000 claims 16
• 125000003275 alpha amino acid group Chemical group 0.000 claims 15
• 150000007523 nucleic acids Chemical class 0.000 claims 14
• 210000004027 cell Anatomy 0.000 claims 13
• 150000001413 amino acids Chemical class 0.000 claims 12
• XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 6
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 6
• 229940035638 gonadotropin-releasing hormone Drugs 0.000 claims 6
• RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 4
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
• 108090000790 Enzymes Proteins 0.000 claims 3
• 102000004190 Enzymes Human genes 0.000 claims 3
• 235000014113 dietary fatty acids Nutrition 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000000194 fatty acid Substances 0.000 claims 3
• 229930195729 fatty acid Natural products 0.000 claims 3
• 150000004665 fatty acids Chemical class 0.000 claims 3
• 239000003550 marker Substances 0.000 claims 3
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
• 150000003384 small molecules Chemical class 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• 239000003053 toxin Substances 0.000 claims 3
• 231100000765 toxin Toxicity 0.000 claims 3
• 108700012359 toxins Proteins 0.000 claims 3
• 229940122815 Aromatase inhibitor Drugs 0.000 claims 2
• 239000000556 agonist Substances 0.000 claims 2
• 230000003444 anaesthetic effect Effects 0.000 claims 2
• 239000003886 aromatase inhibitor Substances 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000002078 nanoshell Substances 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 239000000186 progesterone Substances 0.000 claims 2
• 229960003387 progesterone Drugs 0.000 claims 2
• 238000004393 prognosis Methods 0.000 claims 2
• -1 binding tag Substances 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 239000013022 formulation composition Substances 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1