JP2009519974A - 四環系キナーゼ阻害剤 - Google Patents
四環系キナーゼ阻害剤 Download PDFInfo
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- JP2009519974A JP2009519974A JP2008545979A JP2008545979A JP2009519974A JP 2009519974 A JP2009519974 A JP 2009519974A JP 2008545979 A JP2008545979 A JP 2008545979A JP 2008545979 A JP2008545979 A JP 2008545979A JP 2009519974 A JP2009519974 A JP 2009519974A
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- Prior art keywords
- alkyl
- amino
- carbocycle
- heterocycle
- compound
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D497/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US75123405P | 2005-12-16 | 2005-12-16 | |
| PCT/US2006/062112 WO2007120333A2 (en) | 2005-12-16 | 2006-12-14 | Tetracyclic kinase inhibitors |
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| JP2009519974A true JP2009519974A (ja) | 2009-05-21 |
| JP2009519974A5 JP2009519974A5 (enExample) | 2010-02-04 |
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| EP (1) | EP1968581A4 (enExample) |
| JP (1) | JP2009519974A (enExample) |
| AU (1) | AU2006342024A1 (enExample) |
| CA (1) | CA2631871A1 (enExample) |
| WO (1) | WO2007120333A2 (enExample) |
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| US20090203671A1 (en) * | 2007-11-27 | 2009-08-13 | Abbott Laboratories | Method of treating cancer |
| ES2523580T3 (es) | 2008-01-11 | 2014-11-27 | Albany Molecular Research, Inc. | Piridoindoles substituidos con (1-Azinona) |
| EP2257541B1 (en) | 2008-02-22 | 2013-08-14 | F. Hoffmann-La Roche AG | Modulators for amyloid beta |
| JP5802872B2 (ja) * | 2008-09-23 | 2015-11-04 | ザ ジョンズ ホプキンズ ユニヴァーシティー | 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 |
| CA2736924C (en) | 2008-10-09 | 2016-06-28 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| JP5378532B2 (ja) | 2008-11-10 | 2013-12-25 | エフ．ホフマン−ラ ロシュ アーゲー | 複素環γ−セクレターゼモジュレーター |
| US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8637501B2 (en) | 2009-07-01 | 2014-01-28 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof |
| US8618299B2 (en) | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
| CN106674081A (zh) * | 2016-12-18 | 2017-05-17 | 南京理工大学 | 一种3‑甲硫基吲哚衍生物合成方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003517447A (ja) * | 1998-11-06 | 2003-05-27 | ビーエーエスエフ アクチェンゲゼルシャフト | 三環式ピラゾール誘導体 |
| WO2004071507A1 (en) * | 2003-02-17 | 2004-08-26 | Pharmacia Italia S.P.A. | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2005005414A2 (en) * | 2003-07-08 | 2005-01-20 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2005118587A1 (en) * | 2004-06-02 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Indole derivative and use for treatment of cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3772325A (en) * | 1972-03-24 | 1973-11-13 | American Cyanamid Co | Novel hexahydro cyclohept(b)indoles |
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2006
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- 2006-12-14 AU AU2006342024A patent/AU2006342024A1/en not_active Abandoned
- 2006-12-14 CA CA002631871A patent/CA2631871A1/en not_active Abandoned
- 2006-12-14 WO PCT/US2006/062112 patent/WO2007120333A2/en not_active Ceased
- 2006-12-14 US US12/096,586 patent/US20090131407A1/en not_active Abandoned
- 2006-12-14 EP EP06850957A patent/EP1968581A4/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003517447A (ja) * | 1998-11-06 | 2003-05-27 | ビーエーエスエフ アクチェンゲゼルシャフト | 三環式ピラゾール誘導体 |
| WO2004071507A1 (en) * | 2003-02-17 | 2004-08-26 | Pharmacia Italia S.P.A. | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2005005414A2 (en) * | 2003-07-08 | 2005-01-20 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2005118587A1 (en) * | 2004-06-02 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Indole derivative and use for treatment of cancer |
Also Published As
| Publication number | Publication date |
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| EP1968581A2 (en) | 2008-09-17 |
| CA2631871A1 (en) | 2007-10-25 |
| EP1968581A4 (en) | 2009-05-27 |
| WO2007120333A3 (en) | 2008-01-10 |
| AU2006342024A1 (en) | 2007-10-25 |
| US20090131407A1 (en) | 2009-05-21 |
| WO2007120333A2 (en) | 2007-10-25 |
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