AU2006342024A1 - Tetracyclic kinase inhibitors - Google Patents

Info

Publication number

AU2006342024A1

AU2006342024A1 AU2006342024A AU2006342024A AU2006342024A1 AU 2006342024 A1 AU2006342024 A1 AU 2006342024A1 AU 2006342024 A AU2006342024 A AU 2006342024A AU 2006342024 A AU2006342024 A AU 2006342024A AU 2006342024 A1 AU2006342024 A1 AU 2006342024A1

Authority

AU

Australia

Prior art keywords

alkyl

compound

amino

carbocycle

heterocycle

Prior art date

2005-12-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 229940043355 kinase inhibitor Drugs 0.000 title description 3
• 239000003757 phosphotransferase inhibitor Substances 0.000 title description 3
• -1 amino, carboxyl Chemical group 0.000 claims description 199
• 125000000217 alkyl group Chemical group 0.000 claims description 100
• 150000001875 compounds Chemical class 0.000 claims description 90
• 125000000623 heterocyclic group Chemical group 0.000 claims description 63
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 40
• 229910052736 halogen Inorganic materials 0.000 claims description 33
• 150000002367 halogens Chemical class 0.000 claims description 26
• 108090000433 Aurora kinases Proteins 0.000 claims description 20
• 102000003989 Aurora kinases Human genes 0.000 claims description 20
• 206010028980 Neoplasm Diseases 0.000 claims description 20
• 125000002252 acyl group Chemical group 0.000 claims description 16
• 125000003545 alkoxy group Chemical group 0.000 claims description 16
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 16
• 125000006239 protecting group Chemical group 0.000 claims description 16
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 13
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
• 125000004043 oxo group Chemical group O=* 0.000 claims description 11
• 150000003839 salts Chemical class 0.000 claims description 11
• 229910052701 rubidium Inorganic materials 0.000 claims description 9
• 230000011664 signaling Effects 0.000 claims description 9
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• 241001061127 Thione Species 0.000 claims description 8
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• 230000002401 inhibitory effect Effects 0.000 claims description 6
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 6
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• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
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