JP2009518358A5 - - Google Patents
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- Publication number
- JP2009518358A5 JP2009518358A5 JP2008543819A JP2008543819A JP2009518358A5 JP 2009518358 A5 JP2009518358 A5 JP 2009518358A5 JP 2008543819 A JP2008543819 A JP 2008543819A JP 2008543819 A JP2008543819 A JP 2008543819A JP 2009518358 A5 JP2009518358 A5 JP 2009518358A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- lower alkyl
- lower alkylene
- alkylene
- oxa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- -1 N, N- di - substituted carbamoyl Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Description
Ｎ−モノ−またはＮ,Ｎ−ジ−置換カルバモイルは、とりわけ低級アルキル、フェニル−低級アルキルおよびヒドロキシ−低級アルキル、または低級アルキレン、オキサ−低級アルキレンまたはアザ−低級アルキレン(所望により末端窒素原子を置換されている)から独立して選択される１個または２個の置換基で置換されている。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74278105P | 2005-12-06 | 2005-12-06 | |
| PCT/EP2006/069335 WO2007065898A1 (en) | 2005-12-06 | 2006-12-05 | Pyrimidylaminobenzamide derivatives for the treatment of neurofibromatosis |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013019700A Division JP2013107893A (ja) | 2005-12-06 | 2013-02-04 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
| JP2014240970A Division JP2015091818A (ja) | 2005-12-06 | 2014-11-28 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518358A JP2009518358A (ja) | 2009-05-07 |
| JP2009518358A5 true JP2009518358A5 (ja) | 2010-01-28 |
Family
ID=37831665
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543819A Withdrawn JP2009518358A (ja) | 2005-12-06 | 2006-12-05 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
| JP2013019700A Withdrawn JP2013107893A (ja) | 2005-12-06 | 2013-02-04 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
| JP2014240970A Withdrawn JP2015091818A (ja) | 2005-12-06 | 2014-11-28 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
| JP2017097077A Pending JP2017193553A (ja) | 2005-12-06 | 2017-05-16 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013019700A Withdrawn JP2013107893A (ja) | 2005-12-06 | 2013-02-04 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
| JP2014240970A Withdrawn JP2015091818A (ja) | 2005-12-06 | 2014-11-28 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
| JP2017097077A Pending JP2017193553A (ja) | 2005-12-06 | 2017-05-16 | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20080318988A1 (ja) |
| EP (2) | EP2177222B1 (ja) |
| JP (4) | JP2009518358A (ja) |
| KR (2) | KR101413387B1 (ja) |
| CN (1) | CN101321532B (ja) |
| AU (1) | AU2006323992B2 (ja) |
| BR (1) | BRPI0619416A2 (ja) |
| CA (1) | CA2629132C (ja) |
| ES (2) | ES2391199T3 (ja) |
| PL (1) | PL1959957T3 (ja) |
| PT (1) | PT1959957E (ja) |
| RU (1) | RU2450814C2 (ja) |
| WO (1) | WO2007065898A1 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0619416A2 (pt) * | 2005-12-06 | 2011-10-04 | Novartis Ag | derivados de pirimidilaminobenzamida para o tratamento da neurofibromatose |
| JP5526020B2 (ja) | 2007-06-04 | 2014-06-18 | セルジーン アビロミクス リサーチ， インコーポレイテッド | 複素環化合物およびその使用 |
| KR20110044945A (ko) | 2008-06-27 | 2011-05-03 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 | 신경섬유종 및 관련 종양을 억제 및/또는 치료하기 위한 물질 및 방법 |
| CA2732789A1 (en) * | 2008-08-13 | 2010-02-18 | Novartis Ag | Treatment of pulmonary arterial hypertension |
| EP2186514B1 (en) | 2008-11-14 | 2016-06-29 | Kinki University | Treatment of Malignant Peripheral Nerve Sheath Tumors |
| BR112012009094A8 (pt) * | 2009-10-23 | 2017-10-10 | Novartis Ag | método de tratamento de transtornos proliferativos e outras condições patológicas mediadas por bcr-abl, c-kit, ddr1,ddr2 ou atividade pdgf-r quinase |
| WO2019069986A1 (ja) | 2017-10-03 | 2019-04-11 | 凸版印刷株式会社 | 超音波シール用アンビル及び超音波シール装置 |
| CN113321647A (zh) | 2018-06-15 | 2021-08-31 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0325031D0 (en) | 2003-10-27 | 2003-12-03 | Novartis Ag | Organic compounds |
| SG139747A1 (en) | 2003-11-18 | 2008-02-29 | Novartis Ag | Inhibitors of the mutant form of kit |
| CA2594687C (en) * | 2005-01-28 | 2013-10-29 | Novartis Ag | Use of pyrimidylaminobenzamides for the treatment of diseases that respond to modulation of tie-2 kinase activity |
| BRPI0619416A2 (pt) * | 2005-12-06 | 2011-10-04 | Novartis Ag | derivados de pirimidilaminobenzamida para o tratamento da neurofibromatose |
-
2006
- 2006-12-05 BR BRPI0619416-8A patent/BRPI0619416A2/pt active Search and Examination
- 2006-12-05 KR KR1020087013614A patent/KR101413387B1/ko not_active IP Right Cessation
- 2006-12-05 ES ES06830381T patent/ES2391199T3/es active Active
- 2006-12-05 PL PL06830381T patent/PL1959957T3/pl unknown
- 2006-12-05 AU AU2006323992A patent/AU2006323992B2/en not_active Ceased
- 2006-12-05 CA CA2629132A patent/CA2629132C/en not_active Expired - Fee Related
- 2006-12-05 KR KR1020137034055A patent/KR101498848B1/ko not_active IP Right Cessation
- 2006-12-05 WO PCT/EP2006/069335 patent/WO2007065898A1/en active Application Filing
- 2006-12-05 RU RU2008127264/15A patent/RU2450814C2/ru not_active IP Right Cessation
- 2006-12-05 PT PT06830381T patent/PT1959957E/pt unknown
- 2006-12-05 CN CN2006800456624A patent/CN101321532B/zh not_active Expired - Fee Related
- 2006-12-05 EP EP10150521.2A patent/EP2177222B1/en not_active Not-in-force
- 2006-12-05 ES ES10150521.2T patent/ES2549327T3/es active Active
- 2006-12-05 EP EP06830381A patent/EP1959957B1/en not_active Not-in-force
- 2006-12-05 JP JP2008543819A patent/JP2009518358A/ja not_active Withdrawn
- 2006-12-06 US US12/095,956 patent/US20080318988A1/en not_active Abandoned
-
2010
- 2010-03-24 US US12/730,590 patent/US20100234408A1/en not_active Abandoned
-
2012
- 2012-12-05 US US13/706,249 patent/US8604045B2/en not_active Expired - Fee Related
-
2013
- 2013-02-04 JP JP2013019700A patent/JP2013107893A/ja not_active Withdrawn
- 2013-11-08 US US14/075,256 patent/US20140073660A1/en not_active Abandoned
-
2014
- 2014-11-28 JP JP2014240970A patent/JP2015091818A/ja not_active Withdrawn
-
2017
- 2017-05-16 JP JP2017097077A patent/JP2017193553A/ja active Pending
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