JP2009515853A - Novel pyridopyrazine and use of said pyridopyrazine as a modulator of a kinase - Google Patents

Abstract

  The present invention relates to novel pyrido [2,3-b] pyrazine derivatives represented by the general formulas (I) and (II), the production of the pyrazine derivatives and the use of the pyrazine derivatives as pharmaceuticals, particularly for pathophysiological cell growth. To the use as a medicinal product for the treatment of malignant and other diseases based on

Description

  The present invention relates to pyrido [2,3-b] pyrazine-type kinase-modulators, their preparation and the modulators for the modulation of mis-routed cell signaling pathways, in particular tyrosine kinases, serine / threonine kinases and lipids. Used as a pharmaceutical to affect the function of kinases and to treat malignant or benign tumor diseases and other diseases based on pathological cell proliferation, restenosis, psoriasis, atherosclerosis and cirrhosis Regarding use.

Prior art Protein kinase activation is a central event in the cellular signaling process. Abnormal kinase activation is observed in a variety of disease states. Thus, targeted kinase inhibition is a fundamental therapeutic target.

  Protein phosphorylation is generally initiated by extracellular signals and is a universal mechanism for the control of various cellular events such as metabolic processes, cell proliferation, cell migration, cell differentiation, membrane trafficking and apoptosis. The protein family of kinases is responsible for protein phosphorylation. The enzyme catalyzes the transfer of a phosphate group to a specific substrate protein. Based on their substrate specificity, the kinases fall into three major classes: tyrosine kinases, serine / threonine-kinases and lipid kinases. Both receptor-tyrosine kinases, cytoplasmic tyrosine kinases, serine / threonine kinases and lipid kinases are important proteins of cellular signaling. Overexpression or alteration of the protein plays an important role in diseases based on pathological cell proliferation. This includes inter alia metabolic diseases, connective tissue and vascular diseases and malignant and benign tumor diseases. During tumor development and progression, they often appear as oncogenes, ie as abnormal constitutively active kinase proteins. The result of this excessive kinase activation is, for example, uncontrolled cell growth and decreased cell death. Tumor-induced growth factor stimulation can also cause kinase overstimulation. Therefore, the development of kinase modulators is of particular interest for all pathogenic processes affected by kinases.

  The signaling cascades ras-Raf-Mek-Erk and PI3K-Akt play a central role in cell growth, cell proliferation, apoptosis, adhesion, migration and glucose metabolism. Here, the fundamental involvement in the pathogenesis of diseases such as cancer, neurodegeneration and inflammatory diseases is supported for both the ras-Raf-Mek-Erk-signal pathway and the PI3K-Akt-signal pathway. . Thus, the individual components of the signal cascade are important therapeutic attack sites for intervention of various disease processes (Weinstein-Openheimer CR et al. (2000), Chang F. et al. ( 2003), Katso R. et al. (2001) and Lu Y. et al. (2003)).

  Below, the molecular and biochemical properties of both signal pathways are first described individually.

  Many growth factors, cytokines and oncogenes transmit their growth promoting signals through activation of G protein-bound ras. Said G protein-coupled ras leads to the activation of serine-threonine-kinase Raf and the activation of mitogen-activated protein kinases 1 and 2 (MAPKK1 / 2 or Mek1 / 2) and an extracellular signal-regulated kinase (Erk1) And leads to phosphorylation and activation of MAPK1 and 2, also known as 2). Compared to other signal pathways, the ras-Raf-Mek-Erk-signal pathway combines numerous proto-oncogenes, included ligands, tyrosine kinase receptors, G proteins, kinases and nuclear transcription factors. Tyrosine kinases such as EGFR (Mendelsohn J. et al., 2000) are constrained by overexpression and mutation in tumor progression and often constitutively active signals downstream of ras-Raf-Mek-Erk-signals. Tell the route. Ras mutations occur in 30% of all human tumors (Khleif SN et al., 1999, Marshall C., 1999), with the highest incidence being 90% in pancreatic cancer (Friess H. et al., 1996, Sirivatanaksorn V. et al., 1998). For c-Raf, deregulated expression and / or activation has been described in various tumors (Hoshino R. et al., 1999, McPhillips F. et al., 2001). B-Raf-point mutations have been detected in 66% of all human malignant melanomas, 14% of ovaries, and 12% of colon cancers (Davies H. et al., 2002). Thus, it is not surprising that Erk1 / 2 is most importantly involved in many cellular processes such as cell growth, cell proliferation and cell differentiation (Lewis TS et al., 1998, Chang F. et al. 2003).

  In addition, Raf-kinase members also have Mek-Erk-independent anti-apoptotic functions, whose molecular processes have not yet been fully explained. Possible interaction partners for Mek-Erk-independent Raf activity have been described Ask1, Bcl-2, Akt and Bag1 (Chen J et al., 2001, Troppmaier J. et al., 2003, Rapp U.R. Et al., 2004, Gotz R. et al., 2005). Today, it is hypothesized that both Mek-Erk-dependent and Mek-Erk-independent signaling mechanisms control the activation of ras and Raf in upstream stimuli.

The phosphatidylinositol 3-kinase (PI3Ks) isoenzymes mainly act as lipid kinases and D3-phosphorylate the second messenger lipid PtdIns (phosphatidylinositol) to give PtdIns (3) P, PtdIns (3 4) Catalyze the conversion of P ₂ and PtdIns (3,4,5) P ₃ into phosphatidylinositol phosphate. Class I PI3Ks are structurally composed of a catalytic subunit (p110α, β, γ, δ) and a regulatory subunit (p85α, β, or p101γ). Furthermore, class II enzymes (PI3K-C2α, PI3K-C2β) and class III enzymes (Vps34p) belong to the family of PI3-kinases (Wymann MP et al., 1998, VanHaesbroeck B. et al., 2001). The increase in PIP caused by PI3Ks on the one hand activated the ras-Raf-Mek-Erk-signaling pathway via ras coupling (Rodriguez-Viciana P. et al., 1994) and on the other hand anti-apoptosis The signaling pathway is stimulated by the recruitment of Akt to the cell membrane and, consequently, overactivation of the kinase (Alessi DR et al., 1996, Chang WW et al., 1997, Moore SM et al. 1998). Thus, activation of PI3Ks achieves at least two critical mechanisms of tumor development: activation of cell growth and differentiation and inhibition of apoptosis. Furthermore, PI3K also has protein phosphorylation properties (Dhand et al., 1994, Bondeva T. et al., 1998, Bondev A. et al., 1999, VanHaesbroeck B. et al., 1999). May cause serine autophosphorylation to be regulated in a controlled manner. Furthermore, PI3Ks are known to have kinase-independent regulatory effector properties, for example in controlling cardiac contraction (Cracower MA et al., 2002, Patrucco et al., 2004). Furthermore, since PI3Kδ and PI3Kγ are specifically expressed in hematopoietic cells, isoenzyme-specific PI3Kδ inhibitors and PI3Kγ in the treatment of inflammatory diseases such as rheumatism, asthma and allergies and the treatment of B-cell and T-cell lymphomas It is supported that it is a potential attack site for inhibitors (Okkenhaug K. et al., 2003, Ali K. et al., 2004, Sujobert P. et al., 2005). Recently identified as a proto-oncogene (Shaysteh L. et al., 1999, May Y. et al., 2000, Samuels Y. et al., 2004, Campbell IG et al., 2004, Levine DA, 2005) PI3Kα is regarded as an important target in the treatment of tumor diseases. Thus, the importance of PI3K species as targets for agent development is extremely diverse (Chang F. & Lee JT et al., 2003).

  Of equal interest is the PI3K-related kinase (PIKK), which is a serine / threonine-kinase, mTOR, ATM, ATR, h-SMG-1 and DNA-PK (Chiang G G. et al., 2004). The catalytic domain has high sequence homology to the catalytic domain of PI3Ks.

  Moreover, the loss of the tumor suppressor protein PTEN (Li J. et al., 1997, Stick PA et al., 1997), which has the function of reversing phosphorylation initiated by PI3K, is caused by Akt and its downstream cascade configuration. The contribution to element overactivation emphasizes the causal importance of PI3K as a target molecule for tumor therapy.

  Various inhibitors of individual components of the ras-Raf-Mek-Erk-signaling pathway and the PI3K-Akt-signaling pathway have been published and patented.

  The current development status in the field of kinase inhibitors, particularly in the field of kinase inhibitors of the ras-Raf-Mek-Erk-pathway and the PI3K-Akt-pathway is described in J. Am. S. Sebolt-Leopold et al., 2004 and R.A. It is represented in the overview of Wetzker et al., 2004. In the literature cited, there is a comprehensive list of published patent publications describing the synthesis and use of low molecular weight ras-Raf-Mek-Erk-inhibitors and PI3K-inhibitors.

  Bay 43-9006 (WO99 / 32111, WO03 / 068223), a kinase inhibitor already in clinical trial, is a serine / threonine-kinase and tyrosine such as Raf, VEGFR2 / 3, Flt-3, PDGFR, c-Kit -Relatively non-specific inhibition of kinases and other kinases. The inhibitors are highly important in advanced tumor diseases in which angiogenesis has been induced (eg renal cell carcinoma), but also in melanoma with a high B-Raf-mutation rate. It is done. The clinical effects of Bay 43-9006 are currently being investigated in patients with refractory solid tumors, for example in combination with docetaxel. So far, mild side effects and future antitumor effects have been described. Inhibition of kinases in the PI3K-Akt-signaling pathway is not described or disclosed for Bay 43-9006.

  The Mek1 / 2-inhibitor PD0325901 (WO 02/06213) is currently in Phase I clinical trials. The precursor CI-1040 (WO 00/35435, WO 00/37141) is notable for its high Mek specificity and target affinity. However, the compound was found to be metabolically unstable in Phase I / II studies. Clinical data for PD0325901, the de facto successor, has not yet been published. However, for this Mek-inhibitor, neither the interaction with Erk1 or Erk2, nor the PI3K-Akt-signal pathway inhibitory function or their simultaneous modulation has been published or disclosed.

  The PI3K-inhibitors published so far are in preclinical studies. ICOS has disclosed IC87114, a PI3K-inhibitor with high PI3Kδ isoenzyme specificity (WO 01/81346). For PI103 (WO 04/017950), Piramed Yamanouchi describes the selectivity for the PI3Kα isoform. In the early development of PI3K-inhibitors, there is also a considerable noteworthy research environment (see R. Wetzker et al., 2004 overview).

  Inhibitors of the JNK or p38 SAPK-signaling pathway have been described in the literature (Gum RJ, 1998, Bennett BL et al. 2001, Davies SP et al. 2000). However, the SAPK-inhibitor does not disclose a function of inhibiting PI3Ks, nor is specific inhibition of Erk1 or Erk2, or simultaneous inhibition of SAPKs, Erk1, Erk2 or PI3Ks. Not disclosed.

  Pyrido [2,3-b] pyrazine derivatives substituted at the 6- or 7-position are widely used as pharmacologically effective compounds and as building blocks for synthesis in medicinal chemistry.

  For example, in patent documents WO04 / 104002 and WO04 / 104003, pyrido [2,3-b] pyrazine which may be substituted with a urea group, a thiourea group, an amidine group or a guanidine group at the 6-position or the 7-position is used. It is described. These compounds have properties as inhibitors or modulators of kinases, in particular tyrosine-kinase and serine / threonine-kinase, and have shown use as pharmaceuticals. In contrast, the use of said compounds as modulators of lipid kinases alone or in combination with tyrosine kinases and serine / threonine kinases is not described.

  Furthermore, the patent document WO 99/17759 describes pyrido [2,3-b] pyrazines having carbamates which are especially alkyl, aryl and heteroaryl substituted at the 6-position. These compounds are preferably used to modulate the function of serine-threonine-protein kinase.

  In patent document WO 05/007099 (Kawakami et al.), Inter alia, urea-substituted pyrido [2,3-b] pyrazine is described as an inhibitor of serine / threonine kinase PKB. However, in said patent document, the group R which should explain the substitution range on urea is not further defined, so the range of substitution on urea is not clearly disclosed. Such compounds have been shown for use in the treatment of cancer diseases. However, no specific example of urea substituted pyridopyrazine having this biological property is given. Furthermore, the pyridopyrazine described here is clearly different in structure from the pyrido [2,3-b] pyrazine according to the invention described in the present invention.

  Further examples for pyrido [2,3-b] pyrazines urea substituted at the 6 and 7 positions are given in the patent document WO 05/056547 (Bemis et al.). The compounds in said patent document, however, have an additional carboxyl substitution, sulfoxy substitution, sulfone substitution or imine substitution at the 2- or 3-position, whereby the compounds are structurally described in the present invention. This is clearly different from pyrido [2,3-b] pyrazine according to the present invention. The pyridopyrazine shown in WO 05/056547 has been described as an inhibitor of protein-kinases, in particular GSK-3, Syk and JAK-3. Said compounds have been shown to be used, inter alia, in the treatment of proliferative diseases. The use of said compounds as modulators of lipid kinases alone or in combination with serine / threonine kinases is not described.

  In patent WO 04/005472 by White et al., A pyrido [2,3-b] pyrazine substituted with a carbamate at the 6 position is described, and the compound inhibits bacterial growth as an antimicrobial substance. . Antitumor effects are not described.

  Certain diphenylquinoxalines having a specific alkylpyrrolidine group, alkylpiperidine group or alkylsulfonamide group on one phenyl ring, which may additionally have a urea or carbamate substituent at the 6- or 7-position And -pyrido [2,3-b] pyrazine are described in the patent documents WO 03/084473 (Barnett et al.), WO 03/086394 (Bilodeau et al.) And WO 03/0886403 (Lindsley et al.) Of serine / threonine-kinase Akt. It has been described as an inhibitor of activity. Such compounds have been shown for use in the treatment of cancer diseases. For the exemplary compounds of pyrido [2,3-b] pyrazine described therein, no defined claim for biological action is shown. Moreover, there are clear structural differences from the pyrido [2,3-b] pyrazine according to the invention described in the present invention.

  Further, Delorme et al., WO 03/024448 describes amide-substituted and acrylamide-substituted pyrido [2,3-b] pyrazines, which compounds also contain carbamates as additional substituents, And as a histone deacetylase-inhibitor, it can be used for the treatment of cell proliferative disorders.

  Other literature (C. Temple, Jr .; J. Med. Chem. 1990, 3044-3050) describes, as an example, the synthesis of pyrido [2,3-b] pyrazine derivatives substituted with 6-ethylcarbamate. Has been. The anti-tumor effect is not suggested, rather than disclosed.

  Synthesis of other derivatives of 6-ethylcarbamate substituted pyrido [2,3-b] pyrazine is described in R.C. D. It is described in a publication by Elliott (J. Org. Chem. 1968, 2393-2397). The biological action of the above compounds is not implied, not to mention.

  Publication C.I. Temple, Jr. J. Med. Chem. 1968, 1216-1218 describes the synthesis of 6-ethylcarbamate substituted pyrido [2,3-b] pyrazines and their studies as potential antimalarial agents. The anti-tumor effect is not suggested, rather than disclosed.

DESCRIPTION OF THE INVENTION Accordingly, the present invention is directed to providing novel compounds suitable as modulators of receptor tyrosine kinases, cytoplasmic tyrosine kinases, serine / threonine kinases and lipid kinases. All kinases connected in series in the misregulated signaling cascade should exist as oncogene kinases or as constitutively active enzymes, for example in the case of Raf-Mek-Erk or PI3K-Akt. In the invention, inactive kinases are also considered as therapeutic target proteins. That is, the novel compounds can bind both active and inactive kinases, thereby affecting signal transduction.

  Furthermore, the present invention relates to modulators of receptor tyrosine kinases, cytoplasmic tyrosine kinases, serine / threonine kinases and lipid kinases, particularly from ras-Raf-Mek-Erk and PI3K from one or various signaling cascades. -It is directed to providing new compounds with properties that affect both single kinases from Akt as well as two or more kinases. Simultaneous inhibition of a dual mechanism, ie, two or more signaling cascades, against the therapeutic attack of only one signaling cascade is due to additive effects of all pathogenicity affected by the kinase. It should bring about an improved effect in the treatment of the process.

  Here, surprisingly, novel compounds from a series of pyrido [2,3-b] pyrazines substituted at the 6- or 7-position, for example with a urea group or a thiourea group, are signaled in the wrong pathway. For the regulation of processes, in particular for affecting the function of receptor tyrosine kinases, cytoplasmic tyrosine kinases, serine / threonine kinases and lipid kinases, and malignant or benign tumor diseases such as breast, prostate, lung It has been found suitable for the manufacture of a medicament for the treatment of malignant or benign tumor diseases of the skin, ovary and other diseases based on pathological cell proliferation.

［式中、
（Ａ）
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、"置換されたアリール"であり、その際、"置換されたアリール"は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されている：
（ａ）"アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、−ＮＨ−Ｘ１、−Ｎ（アルキル）₂、−ＮＨＣ（Ｏ）−アルキル、−ＮＨＣ（Ｏ）−シクロアルキル、−ＮＨＣ（Ｏ）−ヘテロシクリル、−ＮＨＣ（Ｏ）−アリール、−ＮＨＣ（Ｏ）−ヘテロアリール、−ＮＨＣ（Ｏ）−アリールアルキル、−ＮＨＣ（Ｏ）−ヘテロアリールアルキル、−ＮＨＳ（Ｏ₂）−アルキル、−ＮＨＳ（Ｏ₂）−シクロアルキル、−ＮＨＳ（Ｏ₂）−ヘテロシクリル、−ＮＨＳ（Ｏ₂）−アリール、−ＮＨＳ（Ｏ₂）−ヘテロアリール、−ＮＨＳ（Ｏ₂）−アリールアルキル、−ＮＨＳ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ−アルキル、−Ｓ−アリール、−Ｓ−ヘテロアリール、−Ｏ−Ｘ２、−ＯＣ（Ｏ）−アルキル、−ＯＣ（Ｏ）−シクロアルキル、−ＯＣ（Ｏ）−ヘテロシクリル、−ＯＣ（Ｏ）−アリール、−ＯＣ（Ｏ）−ヘテロアリール、−ＯＣ（Ｏ）−アリールアルキル、−ＯＣ（Ｏ）−ヘテロアリールアルキル、−ＯＳ（Ｏ₂）−アルキル、−ＯＳ（Ｏ₂）−シクロアルキル、−ＯＳ（Ｏ₂）−ヘテロシクリル、−ＯＳ（Ｏ₂）−アリール、−ＯＳ（Ｏ₂）−ヘテロアリール、−ＯＳ（Ｏ₂）−アリールアルキル、−ＯＳ（Ｏ₂）−ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）Ｏ−Ｘ３、−Ｃ（Ｏ）ＮＨ−Ｘ４、−Ｃ（Ｏ）Ｎ（アルキル）₂、−Ｃ（Ｏ）Ｎ（シクロアルキル）₂、−Ｃ（Ｏ）Ｎ（アリール）₂、−Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、−Ｓ（Ｏ）−アルキル、−Ｓ（Ｏ）−アリール、−Ｓ（Ｏ₂）−アルキル、−Ｓ（Ｏ₂）−アリール、−Ｓ（Ｏ₂）ＮＨ−アルキル、−Ｓ（Ｏ₂）ＮＨ−アリール、−Ｓ（Ｏ₂）ＮＨ−ヘテロアリール、−Ｓ（Ｏ₂）ＮＨ−アリールアルキル、Ｓ（Ｏ₂）Ｏ−アルキル、−Ｓ（Ｏ₂）Ｏ−アリール、−Ｓ（Ｏ₂）Ｏ−アリールアルキル"；
その際、Ｘ１、Ｘ２、Ｘ３、Ｘ４は、互いに無関係に"アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択される；
但し、置換基群（ａ）の上記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されている：
（ｉ）"Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｎ₃、−ＮＨ−シクロアルキル、−ＮＨ−シクロアルキルアルキル、−ＮＨ−ヘテロアリール、−ＮＨ−ヘテロアリールアルキル、−ＮＨ−アリールアルキル、−ＮＨ−ヘテロシクリル、−ＮＨ−ヘテロシクリルアルキル、−ＮＸ５Ｘ６、−Ｓ−シクロアルキル、−Ｓ−シクロアルキルアルキル、−Ｓ−アリール、−Ｓ−アリールアルキル、−Ｓ−ヘテロアリール、−Ｓ−ヘテロアリールアルキル、−Ｓ−ヘテロシクリル、−Ｓ−ヘテロシクリルアルキル、−Ｏ−シクロアルキル、−Ｏ−シクロアルキルアルキル、−Ｏ−アリールアルキル、−Ｏ−ヘテロアリール、−Ｏ−ヘテロアリールアルキル、−Ｏ−ヘテロシクリル、−Ｏ−ヘテロシクリルアルキル、−Ｏ（−Ｘ７−Ｏ）_p−Ｘ８（ｐ＝１、２、３、４、５）、−ＯＰ（Ｏ）（ＯＸ９）（ＯＸ１０）、−Ｃ（Ｏ）Ｏ−Ｘ１１、−Ｃ（Ｏ）ＮＨ₂、−Ｃ（Ｏ）ＮＨ−Ｘ１２、−Ｃ（Ｏ）ＮＸ１３Ｘ１４、−Ｓ（Ｏ₂）−Ｘ１５、−Ｐ（Ｏ）（ＯＨ）₂、−Ｐ（Ｏ）（ＯＸ１６）（ＯＸ１７）、−Ｓｉ（Ｘ１８）（Ｘ１９）（Ｘ２０）、−Ｏ−Ｓｉ（Ｘ２１）（Ｘ２２）（Ｘ２３）、−Ｏ−Ｃ（Ｏ）−Ｏ−Ｘ２４、−Ｏ−Ｃ（Ｏ）−ＮＨ−Ｘ２５、−Ｏ−Ｃ（Ｏ）−ＮＸ２６Ｘ２７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ２８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ２９、−ＮＨ−Ｃ（Ｏ）−ＮＸ３０Ｘ３１、−ＮＸ３２−Ｃ（Ｏ）−Ｏ−Ｘ３３、−ＮＸ３４−Ｃ（Ｏ）−ＮＨ−Ｘ３５、−ＮＸ３６−Ｃ（Ｏ）−ＮＸ３７Ｘ３８、−Ｏ−Ｓ（Ｏ₂）−Ｘ３９、−ＮＨ−Ｃ（Ｏ）−Ｘ４０、−ＮＸ４１−Ｃ（Ｏ）−Ｘ４２、−Ｃ（Ｏ）−Ｘ４３、−ＯＣ（Ｏ）−Ｘ４４、−Ｓ（Ｏ）−Ｘ４５、−Ｓ（Ｏ₂）−ＮＨＸ４６、−Ｓ（Ｏ₂）−ＮＸ４７Ｘ４８、−Ｓ（Ｏ₂）−ＯＸ４９、−Ｏ（−Ｘ５０−Ｏ）_p−Ｈ（ｐ＝１、２、３、４、５）"；
但し、更に、"−Ｎ（アルキル）₂"は、以下の置換基群（ｂ）から選択される少なくとも１つの置換基によって更に置換されている；
その際、Ｘ５、Ｘ６、Ｘ７、Ｘ８、Ｘ９、Ｘ１０、Ｘ１１、Ｘ１２、Ｘ１３、Ｘ１４、Ｘ１５、Ｘ１６、Ｘ１７、Ｘ１８、Ｘ１９、Ｘ２０、Ｘ２１、Ｘ２２、Ｘ２３、Ｘ２４、Ｘ２５、Ｘ２６、Ｘ２７、Ｘ２８、Ｘ２９、Ｘ３０、Ｘ３１、Ｘ３２、Ｘ３３、Ｘ３４、Ｘ３５、Ｘ３６、Ｘ３７、Ｘ３８、Ｘ３９、Ｘ４０、Ｘ４１、Ｘ４２、Ｘ４３、Ｘ４４、Ｘ４５、Ｘ４６、Ｘ４７、Ｘ４８、Ｘ４９、Ｘ５０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｘ１３、Ｘ１４及び／又はＸ２６、Ｘ２７及び／又はＸ３０、Ｘ３１及び／又はＸ３７、Ｘ３８及び／又はＸ４７、Ｘ４８は、一緒になって、"ヘテロシクリル"を形成することもできる；
但し、更に、基Ｚ３もしくはＺ４の一方が、"ヘテロシクリルアルキル"によって置換された"置換されたアリール"である場合に、それぞれ他方の基Ｚ３もしくはＺ４は、"置換もしくは非置換のアリール"ではない；
その際、場合により付加的に、基Ｚ３、Ｚ４の一方は、もしくは付加的に、両方の基Ｚ３、Ｚ４は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｂ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ５１、−ＮＸ５２Ｘ５３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ５４、−Ｃ（Ｏ）Ｏ−Ｘ５５、−Ｃ（Ｏ）ＮＨ−Ｘ５６、−Ｃ（Ｏ）ＮＸ５７Ｘ５８、−Ｏ−Ｘ５９、−Ｏ（−Ｘ６０−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｘ６１−Ｏ）_r−Ｘ６２（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ６３、−ＯＣ（Ｏ）−Ｏ−Ｘ６４、−ＯＣ（Ｏ）−ＮＨＸ６５、−Ｏ−Ｃ（Ｏ）−ＮＸ６６Ｘ６７、−ＯＰ（Ｏ）（ＯＸ６８）（ＯＸ６９）、−ＯＳｉ（Ｘ７０）（Ｘ７１）（Ｘ７２）、−ＯＳ（Ｏ₂）−Ｘ７３、−ＮＨＣ（Ｏ）−Ｘ７４、−ＮＸ７５Ｃ（Ｏ）−Ｘ７６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ７７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ７８、−ＮＨ−Ｃ（Ｏ）−ＮＸ７９Ｘ８０、−ＮＸ８１−Ｃ（Ｏ）−Ｏ−Ｘ８２、−ＮＸ８３−Ｃ（Ｏ）−ＮＨ−Ｘ８４、−ＮＸ８５−Ｃ（Ｏ）−ＮＸ８６Ｘ８７、−ＮＨＳ（Ｏ₂）−Ｘ８８、−ＮＸ８９Ｓ（Ｏ₂）−Ｘ９０、−Ｓ−Ｘ９１、−Ｓ（Ｏ）−Ｘ９２、−Ｓ（Ｏ₂）−Ｘ９３、−Ｓ（Ｏ₂）ＮＨ−Ｘ９４、−Ｓ（Ｏ₂）ＮＸ９５Ｘ９６、−Ｓ（Ｏ₂）Ｏ−Ｘ９７、−Ｐ（Ｏ）（ＯＸ９８）（ＯＸ９９）、−Ｓｉ（Ｘ１００）（Ｘ１０１）（Ｘ１０２）"；
その際、Ｘ５１、Ｘ５２、Ｘ５３、Ｘ５４、Ｘ５５、Ｘ５６、Ｘ５７、Ｘ５８、Ｘ５９、Ｘ６０、Ｘ６１、Ｘ６２、Ｘ６３、Ｘ６４、Ｘ６５、Ｘ６６、Ｘ６７、Ｘ６８、Ｘ６９、Ｘ７０、Ｘ７１、Ｘ７２、Ｘ７３、Ｘ７４、Ｘ７５、Ｘ７６、Ｘ７７、Ｘ７８、Ｘ７９、Ｘ８０、Ｘ８１、Ｘ８２、Ｘ８３、Ｘ８４、Ｘ８５、Ｘ８６、Ｘ８７、Ｘ８８、Ｘ８９、Ｘ９０、Ｘ９１、Ｘ９２、Ｘ９３、Ｘ９４、Ｘ９５、Ｘ９６、Ｘ９７、Ｘ９８、Ｘ９９、Ｘ１００、Ｘ１０１、Ｘ１０２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ５７、Ｘ５８及び／又はＸ６６、Ｘ６７及び／又はＸ７９、Ｘ８０及び／又はＸ８６、Ｘ８７及び／又はＸ９５、Ｘ９６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｂ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ１０３、−ＮＸ１０４Ｘ１０５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ１０６、−Ｃ（Ｏ）Ｏ−Ｘ１０７、−Ｃ（Ｏ）ＮＨ−Ｘ１０８、−Ｃ（Ｏ）ＮＸ１０９Ｘ１１０、−Ｏ−Ｘ１１１、−Ｏ（−Ｘ１１２−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ｘ１１３−Ｏ）_s−Ｘ１１４（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ１１５、−ＯＣ（Ｏ）−Ｏ−Ｘ１１６、−ＯＣ（Ｏ）−ＮＨＸ１１７、−Ｏ−Ｃ（Ｏ）−ＮＸ１１８Ｘ１１９、−ＯＰ（Ｏ）（ＯＸ１２０）（ＯＸ１２１）、−ＯＳｉ（Ｘ１２２）（Ｘ１２３）（Ｘ１２４）、−ＯＳ（Ｏ₂）−Ｘ１２５、−ＮＨＣ（Ｏ）−Ｘ１２６、−ＮＸ１２７Ｃ（Ｏ）−Ｘ１２８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１２９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１３０、−ＮＨ−Ｃ（Ｏ）−ＮＸ１３１Ｘ１３２、−ＮＸ１３３−Ｃ（Ｏ）−Ｏ−Ｘ１３４、−ＮＸ１３５−Ｃ（Ｏ）−ＮＨ−Ｘ１３６、−ＮＸ１３７−Ｃ（Ｏ）−ＮＸ１３８Ｘ１３９、−ＮＨＳ（Ｏ₂）−Ｘ１４０、−ＮＸ１４１Ｓ（Ｏ₂）−Ｘ１４２、−Ｓ−Ｘ１４３、−Ｓ（Ｏ）−Ｘ１４４、−Ｓ（Ｏ₂）−Ｘ１４５、−Ｓ（Ｏ₂）ＮＨ−Ｘ１４６、−Ｓ（Ｏ₂）ＮＸ１４７Ｘ１４８、−Ｓ（Ｏ₂）Ｏ−Ｘ１４９、−Ｐ（Ｏ）（ＯＸ１５０）（ＯＸ１５１）、−Ｓｉ（Ｘ１５２）（Ｘ１５３）（Ｘ１５４）"；
その際、Ｘ１０３、Ｘ１０４、Ｘ１０５、Ｘ１０６、Ｘ１０７、Ｘ１０８、Ｘ１０９、Ｘ１１０、Ｘ１１１、Ｘ１１２、Ｘ１１３、Ｘ１１４、Ｘ１１５、Ｘ１１６、Ｘ１１７、Ｘ１１８、Ｘ１１９、Ｘ１２０、Ｘ１２１、Ｘ１２２、Ｘ１２３、Ｘ１２４、Ｘ１２５、Ｘ１２６、Ｘ１２７、Ｘ１２８、Ｘ１２９、Ｘ１３０、Ｘ１３１、Ｘ１３２、Ｘ１３３、Ｘ１３４、Ｘ１３５、Ｘ１３６、Ｘ１３７、Ｘ１３８、Ｘ１３９、Ｘ１４０、Ｘ１４１、Ｘ１４２、Ｘ１４３、Ｘ１４４、Ｘ１４５、Ｘ１４６、Ｘ１４７、Ｘ１４８、Ｘ１４９、Ｘ１５０、Ｘ１５１、Ｘ１５２、Ｘ１５３、Ｘ１５４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ１０９、Ｘ１１０及び／又はＸ１１８、Ｘ１１９及び／又はＸ１３１、Ｘ１３２及び／又はＸ１３８、Ｘ１３９及び／又はＸ１４７、Ｘ１４８は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）及び／又は置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ１５５、−ＮＸ１５６Ｘ１５７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ１５８、−Ｃ（Ｏ）Ｏ−Ｘ１５９、−Ｃ（Ｏ）ＮＨ−Ｘ１６０、−Ｃ（Ｏ）ＮＸ１６１Ｘ１６２、−Ｏ−Ｘ１６３、−Ｏ（−Ｘ１６４−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｘ１６５−Ｏ）_t−Ｘ１６６（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ１６７、−ＯＣ（Ｏ）−Ｏ−Ｘ１６８、−ＯＣ（Ｏ）−ＮＨＸ１６９、−Ｏ−Ｃ（Ｏ）−ＮＸ１７０Ｘ１７１、−ＯＰ（Ｏ）（ＯＸ１７２）（ＯＸ１７３）、−ＯＳｉ（Ｘ１７４）（Ｘ１７５）（Ｘ１７６）、−ＯＳ（Ｏ₂）−Ｘ１７７、−ＮＨＣ（Ｏ）−Ｘ１７８、−ＮＸ１７９Ｃ（Ｏ）−Ｘ１８０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１８１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１８２、−ＮＨ−Ｃ（Ｏ）−ＮＸ１８３Ｘ１８４、−ＮＸ１８５−Ｃ（Ｏ）−Ｏ−Ｘ１８６、−ＮＸ１８７−Ｃ（Ｏ）−ＮＨ−Ｘ１８８、−ＮＸ１８９−Ｃ（Ｏ）−ＮＸ１９０Ｘ１９１、−ＮＨＳ（Ｏ₂）−Ｘ１９２、−ＮＸ１９３Ｓ（Ｏ₂）−Ｘ１９４、−Ｓ−Ｘ１９５、−Ｓ（Ｏ）−Ｘ１９６、−Ｓ（Ｏ₂）−Ｘ１９７、−Ｓ（Ｏ₂）ＮＨ−Ｘ１９８、−Ｓ（Ｏ₂）ＮＸ１９９Ｘ２００、−Ｓ（Ｏ₂）Ｏ−Ｘ２０１、−Ｐ（Ｏ）（ＯＸ２０２）（ＯＸ２０３）、−Ｓｉ（Ｘ２０４）（Ｘ２０５）（Ｘ２０６）"；
その際、Ｘ１５５、Ｘ１５６、Ｘ１５７、Ｘ１５８、Ｘ１５９、Ｘ１６０、Ｘ１６１、Ｘ１６２、Ｘ１６３、Ｘ１６４、Ｘ１６５、Ｘ１６６、Ｘ１６７、Ｘ１６８、Ｘ１６９、Ｘ１７０、Ｘ１７１、Ｘ１７２、Ｘ１７３、Ｘ１７４、Ｘ１７５、Ｘ１７６、Ｘ１７７、Ｘ１７８、Ｘ１７９、Ｘ１８０、Ｘ１８１、Ｘ１８２、Ｘ１８３、Ｘ１８４、Ｘ１８５、Ｘ１８６、Ｘ１８７、Ｘ１８８、Ｘ１８９、Ｘ１９０、Ｘ１９１、Ｘ１９２、Ｘ１９３、Ｘ１９４、Ｘ１９５、Ｘ１９６、Ｘ１９７、Ｘ１９８、Ｘ１９９、Ｘ２００、Ｘ２０１、Ｘ２０２、Ｘ２０３、Ｘ２０４、Ｘ２０５、Ｘ２０６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ１６１、Ｘ１６２及び／又はＸ１７０、Ｘ１７１及び／又はＸ１８３、Ｘ１８４及び／又はＸ１９０、Ｘ１９１及び／又はＸ１９９、Ｘ２００は、一緒になって、"ヘテロシクリル"を形成することもできる；
又は、
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、"置換されたアリール"であり、その際、"置換されたアリール"は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されている：
（ｃ）"Ｃ₉〜Ｃ₃₀−アルキル、−ＮＸ２０７Ｘ２０８、−ＮＨ−Ｃ₉〜Ｃ₃₀−アルキル、−ＮＨＣ（Ｏ）−シクロアルキルアルキル、−ＮＨＣ（Ｏ）−ヘテロシクリルアルキル、−ＮＨＣ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−ＮＸ２０９Ｃ（Ｏ）−Ｘ２１０、−ＮＸ２１１Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−ＮＨＣ（Ｏ）−ＯＸ２１２、−ＮＸ２１３Ｃ（Ｏ）−ＯＸ２１４、−ＮＨＣ（Ｏ）−ＮＨＸ２１５、−ＮＨＣ（Ｏ）−ＮＸ２１６Ｘ２１７、−ＮＸ２１８Ｃ（Ｏ）−ＮＨＸ２１９、−ＮＸ２２０Ｃ（Ｏ）−ＮＸ２２１Ｘ２２２、−ＮＨＳ（Ｏ₂）−シクロアルキルアルキル、−ＮＨＳ（Ｏ₂）−ヘテロシクリルアルキル、−ＮＸ２２３Ｓ（Ｏ₂）−Ｘ２２４、−Ｏ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ−シクロアルキル、−Ｓ−ヘテロシクリル、−Ｓ−アリールアルキル、−Ｓ−ヘテロアリールアルキル、−Ｓ−シクロアルキルアルキル、−Ｓ−ヘテロシクリルアルキル、−Ｓ−Ｃ₉〜Ｃ₃₀−アルキル、−ＯＣ（Ｏ）−シクロアルキルアルキル、−ＯＣ（Ｏ）−ヘテロシクリルアルキル、−ＯＣ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−ＯＳ（Ｏ₂）−シクロアルキルアルキル、−ＯＳ（Ｏ₂）−ヘテロシクリルアルキル、−ＯＳ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−ＯＣ（Ｏ）−ＯＸ２２５、−ＯＣ（Ｏ）−ＮＨＸ２２６、−ＯＣ（Ｏ）−ＮＸ２２７Ｘ２２８、−ＯＰ（Ｏ）（ＯＸ２２９）（ＯＸ２３０）、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）Ｏ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）ＮＨ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）ＮＸ２３１Ｘ２３２、−Ｃ（Ｏ）ＮＨ−ＯＸ２３３、−Ｃ（Ｏ）ＮＸ２３４−ＯＸ２３５、−Ｃ（Ｏ）ＮＨ−ＮＸ２３６Ｘ２３７、−Ｃ（Ｏ）ＮＸ２３８−ＮＸ２３９Ｘ２４０、−Ｓ（Ｏ）−シクロアルキル、−Ｓ（Ｏ）−ヘテロシクリル、−Ｓ（Ｏ）−ヘテロアリール、−Ｓ（Ｏ）−アリールアルキル、−Ｓ（Ｏ）−ヘテロアリールアルキル、−Ｓ（Ｏ）−シクロアルキルアルキル、−Ｓ（Ｏ）−ヘテロシクリルアルキル、−Ｓ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）ＮＨ−シクロアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロシクリル、−Ｓ（Ｏ₂）ＮＨ−ヘテロアリールアルキル、−Ｓ（Ｏ₂）ＮＨ−シクロアルキルアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）ＮＨ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）Ｏ−シクロアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロシクリル、−Ｓ（Ｏ₂）Ｏ−ヘテロアリール、−Ｓ（Ｏ₂）Ｏ−ヘテロアリールアルキル、−Ｓ（Ｏ₂）Ｏ−シクロアルキルアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）Ｏ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｐ（Ｏ）（ＯＨ）₂、−Ｐ（Ｏ）（ＯＸ２４１）（ＯＸ２４２）、−Ｓｉ（Ｘ２４３）（Ｘ２４４）（Ｘ２４５）、−Ｏ−Ｓｉ（Ｘ２４６）（Ｘ２４７）（Ｘ２４８）"；
その際、Ｘ２０７、Ｘ２０８、Ｘ２０９、Ｘ２１０、Ｘ２１１、Ｘ２１２、Ｘ２１３、Ｘ２１４、Ｘ２１５、Ｘ２１６、Ｘ２１７、Ｘ２１８、Ｘ２１９、Ｘ２２０、Ｘ２２１、Ｘ２２２、Ｘ２２３、Ｘ２２４、Ｘ２２５、Ｘ２２６、Ｘ２２７、Ｘ２２８、Ｘ２２９、Ｘ２３０、Ｘ２３１、Ｘ２３２、Ｘ２３３、Ｘ２３４、Ｘ２３５、Ｘ２３６、Ｘ２３７、Ｘ２３８、Ｘ２３９、Ｘ２４０、Ｘ２４１、Ｘ２４２、Ｘ２４３、Ｘ２４４、Ｘ２４５、Ｘ２４６、Ｘ２４７、Ｘ２４８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｘ２１６、Ｘ２１７及び／又はＸ２２１、Ｘ２２２及び／又はＸ２２７、Ｘ２２８及び／又はＸ２３１、Ｘ２３２及び／又はＸ２３６、Ｘ２３７及び／又はＸ２３９、Ｘ２４０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
但し、置換基"−Ｎ（アルキル）₂"、"−Ｃ（Ｏ）Ｎ（アルキル）₂"、"−Ｃ（Ｏ）Ｎ（シクロアルキル）₂"、"−Ｃ（Ｏ）Ｎ（アリール）₂"、"−Ｃ（Ｏ）Ｎ（ヘテロアリール）₂"は、以下の置換基群（ｉ）から選択される少なくとも１つの置換基によって更に置換されている；
但し、更に、基Ｚ３もしくはＺ４の一方が、"ヘテロシクリルアルキル"によって置換された"置換されたアリール"である場合に、それぞれ他方の基Ｚ３もしくはＺ４は、"置換もしくは非置換のアリール"ではない；
その際、場合により、置換基群（ｃ）の前記の置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ２４９、−ＮＸ２５０Ｘ２５１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ２５２、−Ｃ（Ｏ）Ｏ−Ｘ２５３、−Ｃ（Ｏ）ＮＨ−Ｘ２５４、−Ｃ（Ｏ）ＮＸ２５５Ｘ２５６、−Ｏ−Ｘ２５７、−Ｏ（−Ｘ２５８−Ｏ）_u−Ｈ（ｕ＝１、２、３、４、５）、−Ｏ（−Ｘ２５９−Ｏ）_u−Ｘ２６０（ｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ２６１、−ＯＣ（Ｏ）−Ｏ−Ｘ２６２、−ＯＣ（Ｏ）−ＮＨＸ２６３、−Ｏ−Ｃ（Ｏ）−ＮＸ２６４Ｘ２６５、−ＯＰ（Ｏ）（ＯＸ２６６）（ＯＸ２６７）、−ＯＳｉ（Ｘ２６８）（Ｘ２６９）（Ｘ２７０）、−ＯＳ（Ｏ₂）−Ｘ２７１、−ＮＨＣ（Ｏ）−Ｘ２７２、−ＮＸ２７３Ｃ（Ｏ）−Ｘ２７４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ２７５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ２７６、−ＮＨ−Ｃ（Ｏ）−ＮＸ２７７Ｘ２７８、−ＮＸ２７９−Ｃ（Ｏ）−Ｏ−Ｘ２８０、−ＮＸ２８１−Ｃ（Ｏ）−ＮＨ−Ｘ２８２、−ＮＸ２８３−Ｃ（Ｏ）−ＮＸ２８４Ｘ２８５、−ＮＨＳ（Ｏ₂）−Ｘ２８６、−ＮＸ２８７Ｓ（Ｏ₂）−Ｘ２８８、−Ｓ−Ｘ２８９、−Ｓ（Ｏ）−Ｘ２９０、−Ｓ（Ｏ₂）−Ｘ２９１、−Ｓ（Ｏ₂）ＮＨ−Ｘ２９２、−Ｓ（Ｏ₂）ＮＸ２９３Ｘ２９４、−Ｓ（Ｏ₂）Ｏ−Ｘ２９５、−Ｐ（Ｏ）（ＯＸ２９６）（ＯＸ２９７）、−Ｓｉ（Ｘ２９８）（Ｘ１２９９）（Ｘ３００）"；
その際、Ｘ２４９、Ｘ２５０、Ｘ２５１、Ｘ２５２、Ｘ２５３、Ｘ２５４、Ｘ２５５、Ｘ２５６、Ｘ２５７、Ｘ２５８、Ｘ２５９、Ｘ２６０、Ｘ２６１、Ｘ２６２、Ｘ２６３、Ｘ２６４、Ｘ２６５、Ｘ２６６、Ｘ２６７、Ｘ２６８、Ｘ２６９、Ｘ２７０、Ｘ２７１、Ｘ２７２、Ｘ２７３、Ｘ２７４、Ｘ２７５、Ｘ２７６、Ｘ２７７、Ｘ２７８、Ｘ２７９、Ｘ２８０、Ｘ２８１、Ｘ２８２、Ｘ２８３、Ｘ２８４、Ｘ２８５、Ｘ２８６、Ｘ２８７、Ｘ２８８、Ｘ２８９、Ｘ２９０、Ｘ２９１、Ｘ２９２、Ｘ２９３、Ｘ２９４、Ｘ２９５、Ｘ２９６、Ｘ２９７、Ｘ２９８、Ｘ２９９、Ｘ３００は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ２５５、Ｘ２５６及び／又はＸ２６４、Ｘ２６５及び／又はＸ２７７、Ｘ２７８及び／又はＸ２８４、Ｘ２８５及び／又はＸ２９３、Ｘ２９４は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により付加的に、基Ｚ３、Ｚ３の一方は、もしくは付加的に、両方の基Ｚ３、Ｚ４は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｄ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ３０１、−ＮＸ３０２Ｘ３０３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ３０４、−Ｃ（Ｏ）Ｏ−Ｘ３０５、−Ｃ（Ｏ）ＮＨ−Ｘ３０６、−Ｃ（Ｏ）ＮＸ３０７Ｘ３０８、−Ｏ−Ｘ３０９、−Ｏ（−Ｘ３１０−Ｏ）_uu−Ｈ（ｕｕ＝１、２、３、４、５）、−Ｏ（−Ｘ３１１−Ｏ）_uu−Ｘ３１２（ｕｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ３１３、−ＯＣ（Ｏ）−Ｏ−Ｘ３１４、−ＯＣ（Ｏ）−ＮＨＸ３１５、−Ｏ−Ｃ（Ｏ）−ＮＸ３１６Ｘ３１７、−ＯＰ（Ｏ）（ＯＸ３１８）（ＯＸ３１９）、−ＯＳｉ（Ｘ３２０）（Ｘ３２１）（Ｘ３２２）、−ＯＳ（Ｏ₂）−Ｘ３２３、−ＮＨＣ（Ｏ）−Ｘ３２４、−ＮＸ３２５Ｃ（Ｏ）−Ｘ３２６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ３２７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ３２８、−ＮＨ−Ｃ（Ｏ）−ＮＸ３２９Ｘ３３０、−ＮＸ３３１−Ｃ（Ｏ）−Ｏ−Ｘ３３２、−ＮＸ３３３−Ｃ（Ｏ）−ＮＨ−Ｘ３３４、−ＮＸ３３５−Ｃ（Ｏ）−ＮＸ３３６Ｘ３３７、−ＮＨＳ（Ｏ₂）−Ｘ３３８、−ＮＸ３３９Ｓ（Ｏ₂）−Ｘ３４０、−Ｓ−Ｘ３４１、−Ｓ（Ｏ）−Ｘ３４２、−Ｓ（Ｏ₂）−Ｘ３４３、−Ｓ（Ｏ₂）ＮＨ−Ｘ３４４、−Ｓ（Ｏ₂）ＮＸ３４５Ｘ３４６、−Ｓ（Ｏ₂）Ｏ−Ｘ３４７、−Ｐ（Ｏ）（ＯＸ３４８）（ＯＸ３４９）、−Ｓｉ（Ｘ３５０）（Ｘ３５１）（Ｘ３５２）"；
その際、Ｘ３０１、Ｘ３０２、Ｘ３０３、Ｘ３０４、Ｘ３０５、Ｘ３０６、Ｘ３０７、Ｘ３０８、Ｘ３０９、Ｘ３１０、Ｘ３１１、Ｘ３１２、Ｘ３１３、Ｘ３１４、Ｘ３１５、Ｘ３１６、Ｘ３１７、Ｘ３１８、Ｘ３１９、Ｘ３２０、Ｘ３２１、Ｘ３２２、Ｘ３２３、Ｘ３２４、Ｘ３２５、Ｘ３２６、Ｘ３２７、Ｘ３２８、Ｘ３２９、Ｘ３３０、Ｘ３３１、Ｘ３３２、Ｘ３３３、Ｘ３３４、Ｘ３３５、Ｘ３３６、Ｘ３３７、Ｘ３３８、Ｘ３３９、Ｘ３４０、Ｘ３４１、Ｘ３４２、Ｘ３４３、Ｘ３４４、Ｘ３４５、Ｘ３４６、Ｘ３４７、Ｘ３４８、Ｘ３４９、Ｘ３５０、Ｘ３５１、Ｘ３５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ３０７、Ｘ３０８及び／又はＸ３１６、Ｘ３１７及び／又はＸ３２９、Ｘ３３０及び／又はＸ３３６、Ｘ３３７及び／又はＸ３４５、Ｘ３４６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｄ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ３５３、−ＮＸ３５４Ｘ３５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ３５６、−Ｃ（Ｏ）Ｏ−Ｘ３５７、−Ｃ（Ｏ）ＮＨ−Ｘ３５８、−Ｃ（Ｏ）ＮＸ３５９Ｘ３６０、−Ｏ−Ｘ３６１、−Ｏ（−Ｘ３６２−Ｏ）_v−Ｈ（ｖ＝１、２、３、４、５）、−Ｏ（−Ｘ３６３−Ｏ）_v−Ｘ３６４（ｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ３６５、−ＯＣ（Ｏ）−Ｏ−Ｘ３６６、−ＯＣ（Ｏ）−ＮＨＸ３６７、−Ｏ−Ｃ（Ｏ）−ＮＸ３６８Ｘ３６９、−ＯＰ（Ｏ）（ＯＸ３７０）（ＯＸ３７１）、−ＯＳｉ（Ｘ３７２）（Ｘ３７３）（Ｘ３７４）、−ＯＳ（Ｏ₂）−Ｘ３７５、−ＮＨＣ（Ｏ）−Ｘ３７６、−ＮＸ３７７Ｃ（Ｏ）−Ｘ３７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ３７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ３８０、−ＮＨ−Ｃ（Ｏ）−ＮＸ３８１Ｘ３８２、−ＮＸ３８３−Ｃ（Ｏ）−Ｏ−Ｘ３８４、−ＮＸ３８５−Ｃ（Ｏ）−ＮＨ−Ｘ３８６、−ＮＸ３８７−Ｃ（Ｏ）−ＮＸ３８８Ｘ３８９、−ＮＨＳ（Ｏ₂）−Ｘ３９０、−ＮＸ３９１Ｓ（Ｏ₂）−Ｘ３９２、−Ｓ−Ｘ３９３、−Ｓ（Ｏ）−Ｘ３９４、−Ｓ（Ｏ₂）−Ｘ３９５、−Ｓ（Ｏ₂）ＮＨ−Ｘ３９６、−Ｓ（Ｏ₂）ＮＸ３９７Ｘ３９８、−Ｓ（Ｏ₂）Ｏ−Ｘ３９９、−Ｐ（Ｏ）（ＯＸ４００）（ＯＸ４０１）、−Ｓｉ（Ｘ４０２）（Ｘ４０３）（Ｘ４０４）"；
その際、Ｘ３５３、Ｘ３５４、Ｘ３５５、Ｘ３５６、Ｘ３５７、Ｘ３５８、Ｘ３５９、Ｘ３６０、Ｘ３６１、Ｘ３６２、Ｘ３６３、Ｘ３６４、Ｘ３６５、Ｘ３６６、Ｘ３６７、Ｘ３６８、Ｘ３６９、Ｘ３７０、Ｘ３７１、Ｘ３７２、Ｘ３７３、Ｘ３７４、Ｘ３７５、Ｘ３７６、Ｘ３７７、Ｘ３７８、Ｘ３７９、Ｘ３８０、Ｘ３８１、Ｘ３８２、Ｘ３８３、Ｘ３８４、Ｘ３８５、Ｘ３８６、Ｘ３８７、Ｘ３８８、Ｘ３８９、Ｘ３９０、Ｘ３９１、Ｘ３９２、Ｘ３９３、Ｘ３９４、Ｘ３９５、Ｘ３９６、Ｘ３９７、Ｘ３９８、Ｘ３９９、Ｘ４００、Ｘ４０１、Ｘ４０２、Ｘ４０３、Ｘ４０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ３５９、Ｘ３６０及び／又はＸ３６８、Ｘ３６９及び／又はＸ３８１、Ｘ３８２及び／又はＸ３８８、Ｘ３８９及び／又はＸ３９７、Ｘ３９８は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）及び／又は置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ４０５、−ＮＸ４０６Ｘ４０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ４０８、−Ｃ（Ｏ）Ｏ−Ｘ４０９、−Ｃ（Ｏ）ＮＨ−Ｘ４１０、−Ｃ（Ｏ）ＮＸ４１１Ｘ４１２、−Ｏ−Ｘ４１３、−Ｏ（−Ｘ４１４−Ｏ）_w−Ｈ（ｗ＝１、２、３、４、５）、−Ｏ（−Ｘ４１５−Ｏ）_w−Ｘ４１６（ｗ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ４１７、−ＯＣ（Ｏ）−Ｏ−Ｘ４１８、−ＯＣ（Ｏ）−ＮＨＸ４１９、−Ｏ−Ｃ（Ｏ）−ＮＸ４２０Ｘ４２１、−ＯＰ（Ｏ）（ＯＸ４２２）（ＯＸ４２３）、−ＯＳｉ（Ｘ４２４）（Ｘ４２５）（Ｘ４２６）、−ＯＳ（Ｏ₂）−Ｘ４２７、−ＮＨＣ（Ｏ）−Ｘ４２８、−ＮＸ４２９Ｃ（Ｏ）−Ｘ４３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ４３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ４３２、−ＮＨ−Ｃ（Ｏ）−ＮＸ４３３Ｘ４３４、−ＮＸ４３５−Ｃ（Ｏ）−Ｏ−Ｘ４３６、−ＮＸ４３７−Ｃ（Ｏ）−ＮＨ−Ｘ４３８、−ＮＸ４３９−Ｃ（Ｏ）−ＮＸ４４０Ｘ４４１、−ＮＨＳ（Ｏ₂）−Ｘ４４２、−ＮＸ４４３Ｓ（Ｏ₂）−Ｘ４４４、−Ｓ−Ｘ４４５、−Ｓ（Ｏ）−Ｘ４４６、−Ｓ（Ｏ₂）−Ｘ４４７、−Ｓ（Ｏ₂）ＮＨ−Ｘ４４８、−Ｓ（Ｏ₂）ＮＸ４４９Ｘ４５０、−Ｓ（Ｏ₂）Ｏ−Ｘ４５１、−Ｐ（Ｏ）（ＯＸ４５２）（ＯＸ４５３）、−Ｓｉ（Ｘ４５４）（Ｘ４５５）（Ｘ４５６）"；
その際、Ｘ４０５、Ｘ４０６、Ｘ４０７、Ｘ４０８、Ｘ４０９、Ｘ４１０、Ｘ４１１、Ｘ４１２、Ｘ４１３、Ｘ４１４、Ｘ４１５、Ｘ４１６、Ｘ４１７、Ｘ４１８、Ｘ４１９、Ｘ４２０、Ｘ４２１、Ｘ４２２、Ｘ４２３、Ｘ４２４、Ｘ４２５、Ｘ４２６、Ｘ４２７、Ｘ４２８、Ｘ４２９、Ｘ４３０、Ｘ４３１、Ｘ４３２、Ｘ４３３、Ｘ４３４、Ｘ４３５、Ｘ４３６、Ｘ４３７、Ｘ４３８、Ｘ４３９、Ｘ４４０、Ｘ４４１、Ｘ４４２、Ｘ４４３、Ｘ４４４、Ｘ４４５、Ｘ４４６、Ｘ４４７、Ｘ４４８、Ｘ４４９、Ｘ４５０、Ｘ４５１、Ｘ４５２、Ｘ４５３、Ｘ４５４、Ｘ４５５、Ｘ４５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ４１１、Ｘ４１２及び／又はＸ４２０、Ｘ４２１及び／又はＸ４３３、Ｘ４３４及び／又はＸ４４０、Ｘ４４１及び／又はＸ４４９、Ｘ４５０は、一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ３、Ｚ４の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ３、Ｚ４のどちらも、以下のものからなる群から選択されない：
（ｅ）水素；
（ｆ）ハロゲン、Ｆ、Ｃｌ、Ｂｒ、Ｉ；
（ｇ）非置換もしくは置換されたアルキルもしくはＣ₉〜Ｃ₃₀−アルキル、
その際、場合により、前記のアルキル基もしくはＣ₉〜Ｃ₃₀−アルキル基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ４５７、−ＮＸ４５８Ｘ４５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ４６０、−Ｃ（Ｏ）Ｏ−Ｘ４６１、−Ｃ（Ｏ）ＮＨ−Ｘ４６２、−Ｃ（Ｏ）ＮＸ４６３Ｘ４６４、−Ｏ−Ｘ４６５、−Ｏ（−Ｘ４６６−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−Ｏ（−Ｘ４６７−Ｏ）_x−Ｘ４６８（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ４６９、−ＯＣ（Ｏ）−Ｏ−Ｘ４７０、−ＯＣ（Ｏ）−ＮＨＸ４７１、−Ｏ−Ｃ（Ｏ）−ＮＸ４７２Ｘ４７３、−ＯＰ（Ｏ）（ＯＸ４７４）（ＯＸ４７５）、−ＯＳｉ（Ｘ４７６）（Ｘ４７７）（Ｘ４７８）、−ＯＳ（Ｏ₂）−Ｘ４７９、−ＮＨＣ（Ｏ）−Ｘ４８０、−ＮＸ４８１Ｃ（Ｏ）−Ｘ４８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ４８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ４８４、−ＮＨ−Ｃ（Ｏ）−ＮＸ４８５Ｘ４８６、−ＮＸ４８７−Ｃ（Ｏ）−Ｏ−Ｘ４８８、−ＮＸ４８９−Ｃ（Ｏ）−ＮＨ−Ｘ４９０、−ＮＸ４９１−Ｃ（Ｏ）−ＮＸ４９２Ｘ４９３、−ＮＨＳ（Ｏ₂）−Ｘ４９４、−ＮＸ４９５Ｓ（Ｏ₂）−Ｘ４９６、−Ｓ−Ｘ４９７、−Ｓ（Ｏ）−Ｘ４９８、−Ｓ（Ｏ₂）−Ｘ４９９、−Ｓ（Ｏ₂）ＮＨ−Ｘ５００、−Ｓ（Ｏ₂）ＮＸ５０１Ｘ５０２、−Ｓ（Ｏ₂）Ｏ−Ｘ５０３、−Ｐ（Ｏ）（ＯＸ５０４）（ＯＸ５０５）、−Ｓｉ（Ｘ５０６）（Ｘ５０７）（Ｘ５０８）"；
その際、Ｘ４５７、Ｘ４５８、Ｘ４５９、Ｘ４６０、Ｘ４６１、Ｘ４６２、Ｘ４６３、Ｘ４６４、Ｘ４６５、Ｘ４６６、Ｘ４６７、Ｘ４６８、Ｘ４６９、Ｘ４７０、Ｘ４７１、Ｘ４７２、Ｘ４７３、Ｘ４７４、Ｘ４７５、Ｘ４７６、Ｘ４７７、Ｘ４７８、Ｘ４７９、Ｘ４８０、Ｘ４８１、Ｘ４８２、Ｘ４８３、Ｘ４８４、Ｘ４８５、Ｘ４８６、Ｘ４８７、Ｘ４８８、Ｘ４８９、Ｘ４９０、Ｘ４９１、Ｘ４９２、Ｘ４９３、Ｘ４９４、Ｘ４９５、Ｘ４９６、Ｘ４９７、Ｘ４９８、Ｘ４９９、Ｘ５００、Ｘ５０１、Ｘ５０２、Ｘ５０３、Ｘ５０４、Ｘ５０５、Ｘ５０６、Ｘ５０７、Ｘ５０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ４６３、Ｘ４６４及び／又はＸ４７２、Ｘ４７３及び／又はＸ４８５、Ｘ４８６及び／又はＸ４９２、Ｘ４９３及び／又はＸ５０１、Ｘ５０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ５０９、−ＮＸ５１０Ｘ５１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ５１２、−Ｃ（Ｏ）Ｏ−Ｘ５１３、−Ｃ（Ｏ）ＮＨ−Ｘ５１４、−Ｃ（Ｏ）ＮＸ５１５Ｘ５１６、−Ｏ−Ｘ５１７、−Ｏ（−Ｘ５１８−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｘ５１９−Ｏ）_y−Ｘ５２０（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ５２１、−ＯＣ（Ｏ）−Ｏ−Ｘ５２２、−ＯＣ（Ｏ）−ＮＨＸ５２３、−Ｏ−Ｃ（Ｏ）−ＮＸ５２４Ｘ５２５、−ＯＰ（Ｏ）（ＯＸ５２６）（ＯＸ５２７）、−ＯＳｉ（Ｘ５２８）（Ｘ５２９）（Ｘ５３０）、−ＯＳ（Ｏ₂）−Ｘ５３１、−ＮＨＣ（Ｏ）−Ｘ５３２、−ＮＸ５３３Ｃ（Ｏ）−Ｘ５３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ５３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ５３６、−ＮＨ−Ｃ（Ｏ）−ＮＸ５３７Ｘ５３８、−ＮＸ５３９−Ｃ（Ｏ）−Ｏ−Ｘ５４０、−ＮＸ５４１−Ｃ（Ｏ）−ＮＨ−Ｘ５４２、−ＮＸ５４３−Ｃ（Ｏ）−ＮＸ５４４Ｘ５４５、−ＮＨＳ（Ｏ₂）−Ｘ５４６、−ＮＸ５４７Ｓ（Ｏ₂）−Ｘ５４８、−Ｓ−Ｘ５４９、−Ｓ（Ｏ）−Ｘ５５０、−Ｓ（Ｏ₂）−Ｘ５５１、−Ｓ（Ｏ₂）ＮＨ−Ｘ５５２、−Ｓ（Ｏ₂）ＮＸ５５３Ｘ５５４、−Ｓ（Ｏ₂）Ｏ−Ｘ５５５、−Ｐ（Ｏ）（ＯＸ５５６）（ＯＸ５５７）、−Ｓｉ（Ｘ５５８）（Ｘ５５９）（Ｘ５６０）"；
その際、Ｘ５０９、Ｘ５１０、Ｘ５１１、Ｘ５１２、Ｘ５１３、Ｘ５１４、Ｘ５１５、Ｘ５１６、Ｘ５１７、Ｘ５１８、Ｘ５１９、Ｘ５２０、Ｘ５２１、Ｘ５２２、Ｘ５２３、Ｘ５２４、Ｘ５２５、Ｘ５２６、Ｘ５２７、Ｘ５２８、Ｘ５２９、Ｘ５３０、Ｘ５３１、Ｘ５３２、Ｘ５３３、Ｘ５３４、Ｘ５３５、Ｘ５３６、Ｘ５３７、Ｘ５３８、Ｘ５３９、Ｘ５４０、Ｘ５４１、Ｘ５４２、Ｘ５４３、Ｘ５４４、Ｘ５４５、Ｘ５４６、Ｘ５４７、Ｘ５４８、Ｘ５４９、Ｘ５５０、Ｘ５５１、Ｘ５５２、Ｘ５５３、Ｘ５５４、Ｘ５５５、Ｘ５５６、Ｘ５５７、Ｘ５５８、Ｘ５５９、Ｘ５６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ５１５、Ｘ５１６及び／又はＸ５２４、Ｘ５２５及び／又はＸ５３７、Ｘ５３８及び／又はＸ５４４、Ｘ５４５及び／又はＸ５５３、Ｘ５５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ５６１、−ＮＸ５６２Ｘ５６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ５６４、−Ｃ（Ｏ）Ｏ−Ｘ５６５、−Ｃ（Ｏ）ＮＨ−Ｘ５６６、−Ｃ（Ｏ）ＮＸ５６７Ｘ５６８、−Ｏ−Ｘ５６９、−Ｏ（−Ｘ５７０−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｘ５７１−Ｏ）_z−Ｘ５７２（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ５７３、−ＯＣ（Ｏ）−Ｏ−Ｘ５７４、−ＯＣ（Ｏ）−ＮＨＸ５７５、−Ｏ−Ｃ（Ｏ）−ＮＸ５７６Ｘ５７７、−ＯＰ（Ｏ）（ＯＸ５７８）（ＯＸ５７９）、−ＯＳｉ（Ｘ５８０）（Ｘ５８１）（Ｘ５８２）、−ＯＳ（Ｏ₂）−Ｘ５８３、−ＮＨＣ（Ｏ）−Ｘ５８４、−ＮＸ５８５Ｃ（Ｏ）−Ｘ５８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ５８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ５８８、−ＮＨ−Ｃ（Ｏ）−ＮＸ５８９Ｘ５９０、−ＮＸ５９１−Ｃ（Ｏ）−Ｏ−Ｘ５９２、−ＮＸ５９３−Ｃ（Ｏ）−ＮＨ−Ｘ５９４、−ＮＸ５９５−Ｃ（Ｏ）−ＮＸ５９６Ｘ５９７、−ＮＨＳ（Ｏ₂）−Ｘ５９８、−ＮＸ５９９Ｓ（Ｏ₂）−Ｘ６００、−Ｓ−Ｘ６０１、−Ｓ（Ｏ）−Ｘ６０２、−Ｓ（Ｏ₂）−Ｘ６０３、−Ｓ（Ｏ₂）ＮＨ−Ｘ６０４、−Ｓ（Ｏ₂）ＮＸ６０５Ｘ６０６、−Ｓ（Ｏ₂）Ｏ−Ｘ６０７、−Ｐ（Ｏ）（ＯＸ６０８）（ＯＸ６０９）、−Ｓｉ（Ｘ６１０）（Ｘ６１１）（Ｘ６１２）"；
その際、Ｘ５６１、Ｘ５６２、Ｘ５６３、Ｘ５６４、Ｘ５６５、Ｘ５６６、Ｘ５６７、Ｘ５６８、Ｘ５６９、Ｘ５７０、Ｘ５７１、Ｘ５７２、Ｘ５７３、Ｘ５７４、Ｘ５７５、Ｘ５７６、Ｘ５７７、Ｘ５７８、Ｘ５７９、Ｘ５８０、Ｘ５８１、Ｘ５８２、Ｘ５８３、Ｘ５８４、Ｘ５８５、Ｘ５８６、Ｘ５８７、Ｘ５８８、Ｘ５８９、Ｘ５９０、Ｘ５９１、Ｘ５９２、Ｘ５９３、Ｘ５９４、Ｘ５９５、Ｘ５９６、Ｘ５９７、Ｘ５９８、Ｘ５９９、Ｘ６００、Ｘ６０１、Ｘ６０２、Ｘ６０３、Ｘ６０４、Ｘ６０５、Ｘ６０６、Ｘ６０７、Ｘ６０８、Ｘ６０９、Ｘ６１０、Ｘ６１１、Ｘ６１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ５６７、Ｘ５６８及び／又はＸ５７６、Ｘ５７７及び／又はＸ５８９、Ｘ５９０及び／又はＸ５９６、Ｘ５９７及び／又はＸ６０５、Ｘ６０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｈ）非置換もしくは置換されたアリール、
その際、場合により、前記のアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ６１３、−ＮＸ６１４Ｘ６１５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ６１６、−Ｃ（Ｏ）Ｏ−Ｘ６１７、−Ｃ（Ｏ）ＮＨ−Ｘ６１８、−Ｃ（Ｏ）ＮＸ６１９Ｘ６２０、−Ｏ−Ｘ６２１、−Ｏ（−Ｘ６２２−Ｏ）_a−Ｈ（ａ＝１、２、３、４、５）、−Ｏ（−Ｘ６２３−Ｏ）_a−Ｘ６２４（ａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ６２５、−ＯＣ（Ｏ）−Ｏ−Ｘ６２６、−ＯＣ（Ｏ）−ＮＨＸ６２７、−Ｏ−Ｃ（Ｏ）−ＮＸ６２８Ｘ６２９、−ＯＰ（Ｏ）（ＯＸ６３０）（ＯＸ６３１）、−ＯＳｉ（Ｘ６３２）（Ｘ６３３）（Ｘ６３４）、−ＯＳ（Ｏ₂）−Ｘ６３５、−ＮＨＣ（Ｏ）−Ｘ６３６、−ＮＸ６３７Ｃ（Ｏ）−Ｘ６３８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ６３９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ６４０、−ＮＨ−Ｃ（Ｏ）−ＮＸ６４１Ｘ６４２、−ＮＸ６４３−Ｃ（Ｏ）−Ｏ−Ｘ６４４、−ＮＸ６４５−Ｃ（Ｏ）−ＮＨ−Ｘ６４６、−ＮＸ６４７−Ｃ（Ｏ）−ＮＸ６４８Ｘ６４９、−ＮＨＳ（Ｏ₂）−Ｘ６５０、−ＮＸ６５１Ｓ（Ｏ₂）−Ｘ６５２、−Ｓ−Ｘ６５３、−Ｓ（Ｏ）−Ｘ６５４、−Ｓ（Ｏ₂）−Ｘ６５５、−Ｓ（Ｏ₂）ＮＨ−Ｘ６５６、−Ｓ（Ｏ₂）ＮＸ６５７Ｘ６５８、−Ｓ（Ｏ₂）Ｏ−Ｘ６５９、−Ｐ（Ｏ）（ＯＸ６６０）（ＯＸ６６１）、−Ｓｉ（Ｘ６６２）（Ｘ６６３）（Ｘ６６４）"；
その際、Ｘ６１３、Ｘ６１４、Ｘ６１５、Ｘ６１６、Ｘ６１７、Ｘ６１８、Ｘ６１９、Ｘ６２０、Ｘ６２１、Ｘ６２２、Ｘ６２３、Ｘ６２４、Ｘ６２５、Ｘ６２６、Ｘ６２７、Ｘ６２８、Ｘ６２９、Ｘ６３０、Ｘ６３１、Ｘ６３２、Ｘ６３３、Ｘ６３４、Ｘ６３５、Ｘ６３６、Ｘ６３７、Ｘ６３８、Ｘ６３９、Ｘ６４０、Ｘ６４１、Ｘ６４２、Ｘ６４３、Ｘ６４４、Ｘ６４５、Ｘ６４６、Ｘ６４７、Ｘ６４８、Ｘ６４９、Ｘ６５０、Ｘ６５１、Ｘ６５２、Ｘ６５３、Ｘ６５４、Ｘ６５５、Ｘ６５６、Ｘ６５７、Ｘ６５８、Ｘ６５９、Ｘ６６０、Ｘ６６１、Ｘ６６２、Ｘ６６３、Ｘ６６４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ６１９、Ｘ６２０及び／又はＸ６２８、Ｘ６２９及び／又はＸ６４１、Ｘ６４２及び／又はＸ６４８、Ｘ６４９及び／又はＸ６５７、Ｘ６５８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ６６５、−ＮＸ６６６Ｘ６６７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ６６８、−Ｃ（Ｏ）Ｏ−Ｘ６６９、−Ｃ（Ｏ）ＮＨ−Ｘ６７０、−Ｃ（Ｏ）ＮＸ６７１Ｘ６７２、−Ｏ−Ｘ６７３、−Ｏ（−Ｘ６７４−Ｏ）_b−Ｈ（ｂ＝１、２、３、４、５）、−Ｏ（−Ｘ６７５−Ｏ）_b−Ｘ６７６（ｂ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ６７７、−ＯＣ（Ｏ）−Ｏ−Ｘ６７８、−ＯＣ（Ｏ）−ＮＨＸ６７９、−Ｏ−Ｃ（Ｏ）−ＮＸ６８０Ｘ６８１、−ＯＰ（Ｏ）（ＯＸ６８２）（ＯＸ６８３）、−ＯＳｉ（Ｘ６８４）（Ｘ６８５）（Ｘ６８６）、−ＯＳ（Ｏ₂）−Ｘ６８７、−ＮＨＣ（Ｏ）−Ｘ６８８、−ＮＸ６８９Ｃ（Ｏ）−Ｘ６９０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ６９１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ６９２、−ＮＨ−Ｃ（Ｏ）−ＮＸ６９３Ｘ６９４、−ＮＸ６９５−Ｃ（Ｏ）−Ｏ−Ｘ６９６、−ＮＸ６９７−Ｃ（Ｏ）−ＮＨ−Ｘ６９８、−ＮＸ６９９−Ｃ（Ｏ）−ＮＸ７００Ｘ７０１、−ＮＨＳ（Ｏ₂）−Ｘ７０２、−ＮＸ７０３Ｓ（Ｏ₂）−Ｘ７０４、−Ｓ−Ｘ７０５、−Ｓ（Ｏ）−Ｘ７０６、−Ｓ（Ｏ₂）−Ｘ７０７、−Ｓ（Ｏ₂）ＮＨ−Ｘ７０８、−Ｓ（Ｏ₂）ＮＸ７０９Ｘ７１０、−Ｓ（Ｏ₂）Ｏ−Ｘ７１１、−Ｐ（Ｏ）（ＯＸ７１２）（ＯＸ７１３）、−Ｓｉ（Ｘ７１４）（Ｘ７１５）（Ｘ７１６）"；
その際、Ｘ６６５、Ｘ６６６、Ｘ６６７、Ｘ６６８、Ｘ６６９、Ｘ６７０、Ｘ６７１、Ｘ６７２、Ｘ６７３、Ｘ６７４、Ｘ６７５、Ｘ６７６、Ｘ６７７、Ｘ６７８、Ｘ６７９、Ｘ６８０、Ｘ６８１、Ｘ６８２、Ｘ６８３、Ｘ６８４、Ｘ６８５、Ｘ６８６、Ｘ６８７、Ｘ６８８、Ｘ６８９、Ｘ６９０、Ｘ６９１、Ｘ６９２、Ｘ６９３、Ｘ６９４、Ｘ６９５、Ｘ６９６、Ｘ６９７、Ｘ６９８、Ｘ６９９、Ｘ７００、Ｘ７０１、Ｘ７０２、Ｘ７０３、Ｘ７０４、Ｘ７０５、Ｘ７０６、Ｘ７０７、Ｘ７０８、Ｘ７０９、Ｘ７１０、Ｘ７１１、Ｘ７１２、Ｘ７１３、Ｘ７１４、Ｘ７１５、Ｘ７１６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ６７１、Ｘ６７２及び／又はＸ６８０、Ｘ６８１及び／又はＸ６９３、Ｘ６９４及び／又はＸ７００、Ｘ７０１及び／又はＸ７０９、Ｘ７１０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ７１７、−ＮＸ７１８Ｘ７１９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ７２０、−Ｃ（Ｏ）Ｏ−Ｘ７２１、−Ｃ（Ｏ）ＮＨ−Ｘ７２２、−Ｃ（Ｏ）ＮＸ７２３Ｘ７２４、−Ｏ−Ｘ７２５、−Ｏ（−Ｘ７２６−Ｏ）_c−Ｈ（ｃ＝１、２、３、４、５）、−Ｏ（−Ｘ７２７−Ｏ）_c−Ｘ７２８（ｃ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ７２９、−ＯＣ（Ｏ）−Ｏ−Ｘ７３０、−ＯＣ（Ｏ）−ＮＨＸ７３１、−Ｏ−Ｃ（Ｏ）−ＮＸ７３２Ｘ７３３、−ＯＰ（Ｏ）（ＯＸ７３４）（ＯＸ７３５）、−ＯＳｉ（Ｘ７３６）（Ｘ７３７）（Ｘ７３８）、−ＯＳ（Ｏ₂）−Ｘ７３９、−ＮＨＣ（Ｏ）−Ｘ７４０、−ＮＸ７４１Ｃ（Ｏ）−Ｘ７４２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ７４３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ７４４、−ＮＨ−Ｃ（Ｏ）−ＮＸ７４５Ｘ７４６、−ＮＸ７４７−Ｃ（Ｏ）−Ｏ−Ｘ７４８、−ＮＸ７４９−Ｃ（Ｏ）−ＮＨ−Ｘ７５０、−ＮＸ７５１−Ｃ（Ｏ）−ＮＸ７５２Ｘ７５３、−ＮＨＳ（Ｏ₂）−Ｘ７５４、−ＮＸ７５５Ｓ（Ｏ₂）−Ｘ７５６、−Ｓ−Ｘ７５７、−Ｓ（Ｏ）−Ｘ７５８、−Ｓ（Ｏ₂）−Ｘ７５９、−Ｓ（Ｏ₂）ＮＨ−Ｘ７６０、−Ｓ（Ｏ₂）ＮＸ７６１Ｘ７６２、−Ｓ（Ｏ₂）Ｏ−Ｘ７６３、−Ｐ（Ｏ）（ＯＸ７６４）（ＯＸ７６５）、−Ｓｉ（Ｘ７６６）（Ｘ７６７）（Ｘ７６８）"；
その際、Ｘ７１７、Ｘ７１８、Ｘ７１９、Ｘ７２０、Ｘ７２１、Ｘ７２２、Ｘ７２３、Ｘ７２４、Ｘ７２５、Ｘ７２６、Ｘ７２７、Ｘ７２８、Ｘ７２９、Ｘ７３０、Ｘ７３１、Ｘ７３２、Ｘ７３３、Ｘ７３４、Ｘ７３５、Ｘ７３６、Ｘ７３７、Ｘ７３８、Ｘ７３９、Ｘ７４０、Ｘ７４１、Ｘ７４２、Ｘ７４３、Ｘ７４４、Ｘ７４５、Ｘ７４６、Ｘ７４７、Ｘ７４８、Ｘ７４９、Ｘ７５０、Ｘ７５１、Ｘ７５２、Ｘ７５３、Ｘ７５４、Ｘ７５５、Ｘ７５６、Ｘ７５７、Ｘ７５８、Ｘ７５９、Ｘ７６０、Ｘ７６１、Ｘ７６２、Ｘ７６３、Ｘ７６４、Ｘ７６５、Ｘ７６６、Ｘ７６７、Ｘ７６８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ７２３、Ｘ７２４及び／又はＸ７３２、Ｘ７３３及び／又はＸ７４５、Ｘ７４６及び／又はＸ７５２、Ｘ７５３及び／又はＸ７６１、Ｘ７６２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｊ）非置換もしくは置換されたヘテロアリール、
その際、場合により、前記のヘテロアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ７６９、−ＮＸ７７０Ｘ７７１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ７７２、−Ｃ（Ｏ）Ｏ−Ｘ７７３、−Ｃ（Ｏ）ＮＨ−Ｘ７７４、−Ｃ（Ｏ）ＮＸ７７５Ｘ７７６、−Ｏ−Ｘ７７７、−Ｏ（−Ｘ７７８−Ｏ）_d−Ｈ（ｄ＝１、２、３、４、５）、−Ｏ（−Ｘ７７９−Ｏ）_d−Ｘ７８０（ｄ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ７８１、−ＯＣ（Ｏ）−Ｏ−Ｘ７８２、−ＯＣ（Ｏ）−ＮＨＸ７８３、−Ｏ−Ｃ（Ｏ）−ＮＸ７８４Ｘ７８５、−ＯＰ（Ｏ）（ＯＸ７８６）（ＯＸ７８７）、−ＯＳｉ（Ｘ７８８）（Ｘ７８９）（Ｘ７９０）、−ＯＳ（Ｏ₂）−Ｘ７９１、−ＮＨＣ（Ｏ）−Ｘ７９２、−ＮＸ７９３Ｃ（Ｏ）−Ｘ７９４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ７９５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ７９６、−ＮＨ−Ｃ（Ｏ）−ＮＸ７９７Ｘ７９８、−ＮＸ７９９−Ｃ（Ｏ）−Ｏ−Ｘ８００、−ＮＸ８０１−Ｃ（Ｏ）−ＮＨ−Ｘ８０２、−ＮＸ８０３−Ｃ（Ｏ）−ＮＸ８０４Ｘ８０５、−ＮＨＳ（Ｏ₂）−Ｘ８０６、−ＮＸ８０７Ｓ（Ｏ₂）−Ｘ８０８、−Ｓ−Ｘ８０９、−Ｓ（Ｏ）−Ｘ８１０、−Ｓ（Ｏ₂）−Ｘ８１１、−Ｓ（Ｏ₂）ＮＨ−Ｘ８１２、−Ｓ（Ｏ₂）ＮＸ８１３Ｘ８１４、−Ｓ（Ｏ₂）Ｏ−Ｘ８１５、−Ｐ（Ｏ）（ＯＸ８１６）（ＯＸ８１７）、−Ｓｉ（Ｘ８１８）（Ｘ８１９）（Ｘ８２０）"；
その際、Ｘ７６９、Ｘ７７０、Ｘ７７１、Ｘ７７２、Ｘ７７３、Ｘ７７４、Ｘ７７５、Ｘ７７６、Ｘ７７７、Ｘ７７８、Ｘ７７９、Ｘ７８０、Ｘ７８１、Ｘ７８２、Ｘ７８３、Ｘ７８４、Ｘ７８５、Ｘ７８６、Ｘ７８７、Ｘ７８８、Ｘ７８９、Ｘ７９０、Ｘ７９１、Ｘ７９２、Ｘ７９３、Ｘ７９４、Ｘ７９５、Ｘ７９６、Ｘ７９７、Ｘ７９８、Ｘ７９９、Ｘ８００、Ｘ８０１、Ｘ８０２、Ｘ８０３、Ｘ８０４、Ｘ８０５、Ｘ８０６、Ｘ８０７、Ｘ８０８、Ｘ８０９、Ｘ８１０、Ｘ８１１、Ｘ８１２、Ｘ８１３、Ｘ８１４、Ｘ８１５、Ｘ８１６、Ｘ８１７、Ｘ８１８、Ｘ８１９、Ｘ８２０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ７７５、Ｘ７７６及び／又はＸ７８４、Ｘ７８５及び／又はＸ７９７、Ｘ７９８及び／又はＸ８０４、Ｘ８０５及び／又はＸ８１３、Ｘ８１４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ８２１、−ＮＸ８２２Ｘ８２３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ８２４、−Ｃ（Ｏ）Ｏ−Ｘ８２５、−Ｃ（Ｏ）ＮＨ−Ｘ８２６、−Ｃ（Ｏ）ＮＸ８２７Ｘ８２８、−Ｏ−Ｘ８２９、−Ｏ（−Ｘ８３０−Ｏ）_e−Ｈ（ｅ＝１、２、３、４、５）、−Ｏ（−Ｘ８３１−Ｏ）_e−Ｘ８３２（ｅ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ８３３、−ＯＣ（Ｏ）−Ｏ−Ｘ８３４、−ＯＣ（Ｏ）−ＮＨＸ８３５、−Ｏ−Ｃ（Ｏ）−ＮＸ８３６Ｘ８３７、−ＯＰ（Ｏ）（ＯＸ８３８）（ＯＸ８３９）、−ＯＳｉ（Ｘ８４０）（Ｘ８４１）（Ｘ８４２）、−ＯＳ（Ｏ₂）−Ｘ８４３、−ＮＨＣ（Ｏ）−Ｘ８４４、−ＮＸ８４５Ｃ（Ｏ）−Ｘ８４６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ８４７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ８４８、−ＮＨ−Ｃ（Ｏ）−ＮＸ８４９Ｘ８５０、−ＮＸ８５１−Ｃ（Ｏ）−Ｏ−Ｘ８５２、−ＮＸ８５３−Ｃ（Ｏ）−ＮＨ−Ｘ８５４、−ＮＸ８５５−Ｃ（Ｏ）−ＮＸ８５６Ｘ８５７、−ＮＨＳ（Ｏ₂）−Ｘ８５８、−ＮＸ８５９Ｓ（Ｏ₂）−Ｘ８６０、−Ｓ−Ｘ８６１、−Ｓ（Ｏ）−Ｘ８６２、−Ｓ（Ｏ₂）−Ｘ８６３、−Ｓ（Ｏ₂）ＮＨ−Ｘ８６４、−Ｓ（Ｏ₂）ＮＸ８６５Ｘ８６６、−Ｓ（Ｏ₂）Ｏ−Ｘ８６７、−Ｐ（Ｏ）（ＯＸ８６８）（ＯＸ８６９）、−Ｓｉ（Ｘ８７０）（Ｘ８７１）（Ｘ８７２）"；
その際、Ｘ８２１、Ｘ８２２、Ｘ８２３、Ｘ８２４、Ｘ８２５、Ｘ８２６、Ｘ８２７、Ｘ８２８、Ｘ８２９、Ｘ８３０、Ｘ８３１、Ｘ８３２、Ｘ８３３、Ｘ８３４、Ｘ８３５、Ｘ８３６、Ｘ８３７、Ｘ８３８、Ｘ８３９、Ｘ８４０、Ｘ８４１、Ｘ８４２、Ｘ８４３、Ｘ８４４、Ｘ８４５、Ｘ８４６、Ｘ８４７、Ｘ８４８、Ｘ８４９、Ｘ８５０、Ｘ８５１、Ｘ８５２、Ｘ８５３、Ｘ８５４、Ｘ８５５、Ｘ８５６、Ｘ８５７、Ｘ８５８、Ｘ８５９、Ｘ８６０、Ｘ８６１、Ｘ８６２、Ｘ８６３、Ｘ８６４、Ｘ８６５、Ｘ８６６、Ｘ８６７、Ｘ８６８、Ｘ８６９、Ｘ８７０、Ｘ８７１、Ｘ８７２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ８２７、Ｘ８２８及び／又はＸ８３６、Ｘ８３７及び／又はＸ８４９、Ｘ８５０及び／又はＸ８５６、Ｘ８５７及び／又はＸ８６５、Ｘ８６６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ８７３、−ＮＸ８７４Ｘ８７５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ８７６、−Ｃ（Ｏ）Ｏ−Ｘ８７７、−Ｃ（Ｏ）ＮＨ−Ｘ８７８、−Ｃ（Ｏ）ＮＸ８７９Ｘ８８０、−Ｏ−Ｘ８８１、−Ｏ（−Ｘ８８２−Ｏ）_f−Ｈ（ｆ＝１、２、３、４、５）、−Ｏ（−Ｘ８８３−Ｏ）_f−Ｘ８８４（ｆ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ８８５、−ＯＣ（Ｏ）−Ｏ−Ｘ８８６、−ＯＣ（Ｏ）−ＮＨＸ８８７、−Ｏ−Ｃ（Ｏ）−ＮＸ８８８Ｘ８８９、−ＯＰ（Ｏ）（ＯＸ８９０）（ＯＸ８９１）、−ＯＳｉ（Ｘ８９２）（Ｘ８９３）（Ｘ８９４）、−ＯＳ（Ｏ₂）−Ｘ８９５、−ＮＨＣ（Ｏ）−Ｘ８９６、−ＮＸ８９７Ｃ（Ｏ）−Ｘ８９８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ８９９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ９００、−ＮＨ−Ｃ（Ｏ）−ＮＸ９０１Ｘ９０２、−ＮＸ９０３−Ｃ（Ｏ）−Ｏ−Ｘ９０４、−ＮＸ９０５−Ｃ（Ｏ）−ＮＨ−Ｘ９０６、−ＮＸ９０７−Ｃ（Ｏ）−ＮＸ９０８Ｘ９０９、−ＮＨＳ（Ｏ₂）−Ｘ９１０、−ＮＸ９１１Ｓ（Ｏ₂）−Ｘ９１２、−Ｓ−Ｘ９１３、−Ｓ（Ｏ）−Ｘ９１４、−Ｓ（Ｏ₂）−Ｘ９１５、−Ｓ（Ｏ₂）ＮＨ−Ｘ９１６、−Ｓ（Ｏ₂）ＮＸ９１７Ｘ９１８、−Ｓ（Ｏ₂）Ｏ−Ｘ９１９、−Ｐ（Ｏ）（ＯＸ９２０）（ＯＸ９２１）、−Ｓｉ（Ｘ９２２）（Ｘ９２３）（Ｘ９２４）"；
その際、Ｘ８７３、Ｘ８７４、Ｘ８７５、Ｘ８７６、Ｘ８７７、Ｘ８７８、Ｘ８７９、Ｘ８８０、Ｘ８８１、Ｘ８８２、Ｘ８８３、Ｘ８８４、Ｘ８８５、Ｘ８８６、Ｘ８８７、Ｘ８８８、Ｘ８８９、Ｘ８９０、Ｘ８９１、Ｘ８９２、Ｘ８９３、Ｘ８９４、Ｘ８９５、Ｘ８９６、Ｘ８９７、Ｘ８９８、Ｘ８９９、Ｘ９００、Ｘ９０１、Ｘ９０２、Ｘ９０３、Ｘ９０４、Ｘ９０５、Ｘ９０６、Ｘ９０７、Ｘ９０８、Ｘ９０９、Ｘ９１０、Ｘ９１１、Ｘ９１２、Ｘ９１３、Ｘ９１４、Ｘ９１５、Ｘ９１６、Ｘ９１７、Ｘ９１８、Ｘ９１９、Ｘ９２０、Ｘ９２１、Ｘ９２２、Ｘ９２３、Ｘ９２４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ８７９、Ｘ８８０及び／又はＸ８８８、Ｘ８８９及び／又はＸ９０１、Ｘ９０２及び／又はＸ９０８、Ｘ９０９及び／又はＸ９１７、Ｘ９１８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｋ）ＯＺ６、
その際、Ｚ６は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ９２５、−ＮＸ９２６Ｘ９２７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ９２８、−Ｃ（Ｏ）Ｏ−Ｘ９２９、−Ｃ（Ｏ）ＮＨ−Ｘ９３０、−Ｃ（Ｏ）ＮＸ９３１Ｘ９３２、−Ｏ−Ｘ９３３、−Ｏ（−Ｘ９３４−Ｏ）_g−Ｈ（ｇ＝１、２、３、４、５）、−Ｏ（−Ｘ９３５−Ｏ）_g−Ｘ９３６（ｇ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ９３７、−ＯＣ（Ｏ）−Ｏ−Ｘ９３８、−ＯＣ（Ｏ）−ＮＨＸ９３９、−Ｏ−Ｃ（Ｏ）−ＮＸ９４０Ｘ９４１、−ＯＰ（Ｏ）（ＯＸ９４２）（ＯＸ９４３）、−ＯＳｉ（Ｘ９４４）（Ｘ９４５）（Ｘ９４６）、−ＯＳ（Ｏ₂）−Ｘ９４７、−ＮＨＣ（Ｏ）−Ｘ９４８、−ＮＸ９４９Ｃ（Ｏ）−Ｘ９５０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ９５１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ９５２、−ＮＨ−Ｃ（Ｏ）−ＮＸ９５３Ｘ９５４、−ＮＸ９５５−Ｃ（Ｏ）−Ｏ−Ｘ９５６、−ＮＸ９５７−Ｃ（Ｏ）−ＮＨ−Ｘ９５８、−ＮＸ９５９−Ｃ（Ｏ）−ＮＸ９６０Ｘ９６１、−ＮＨＳ（Ｏ₂）−Ｘ９６２、−ＮＸ９６３Ｓ（Ｏ₂）−Ｘ９６４、−Ｓ−Ｘ９６５、−Ｓ（Ｏ）−Ｘ９６６、−Ｓ（Ｏ₂）−Ｘ９６７、−Ｓ（Ｏ₂）ＮＨ−Ｘ９６８、−Ｓ（Ｏ₂）ＮＸ９６９Ｘ９７０、−Ｓ（Ｏ₂）Ｏ−Ｘ９７１、−Ｐ（Ｏ）（ＯＸ９７２）（ＯＸ９７３）、−Ｓｉ（Ｘ９７４）（Ｘ９７５）（Ｘ９７６）"；
その際、Ｘ９２５、Ｘ９２６、Ｘ９２７、Ｘ９２８、Ｘ９２９、Ｘ９３０、Ｘ９３１、Ｘ９３２、Ｘ９３３、Ｘ９３４、Ｘ９３５、Ｘ９３６、Ｘ９３７、Ｘ９３８、Ｘ９３９、Ｘ９４０、Ｘ９４１、Ｘ９４２、Ｘ９４３、Ｘ９４４、Ｘ９４５、Ｘ９４６、Ｘ９４７、Ｘ９４８、Ｘ９４９、Ｘ９５０、Ｘ９５１、Ｘ９５２、Ｘ９５３、Ｘ９５４、Ｘ９５５、Ｘ９５６、Ｘ９５７、Ｘ９５８、Ｘ９５９、Ｘ９６０、Ｘ９６１、Ｘ９６２、Ｘ９６３、Ｘ９６４、Ｘ９６５、Ｘ９６６、Ｘ９６７、Ｘ９６８、Ｘ９６９、Ｘ９７０、Ｘ９７１、Ｘ９７２、Ｘ９７３、Ｘ９７４、Ｘ９７５、Ｘ９７６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ９３１、Ｘ９３２及び／又はＸ９４０、Ｘ９４１及び／又はＸ９５３、Ｘ９５４及び／又はＸ９６０、Ｘ９６１及び／又はＸ９６９、Ｘ９７０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ９７７、−ＮＸ９７８Ｘ９７９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ９８０、−Ｃ（Ｏ）Ｏ−Ｘ９８１、−Ｃ（Ｏ）ＮＨ−Ｘ９８２、−Ｃ（Ｏ）ＮＸ９８３Ｘ９８４、−Ｏ−Ｘ９８５、−Ｏ（−Ｘ９８６−Ｏ）_h−Ｈ（ｈ＝１、２、３、４、５）、−Ｏ（−Ｘ９８７−Ｏ）_h−Ｘ９８８（ｈ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ９８９、−ＯＣ（Ｏ）−Ｏ−Ｘ９９０、−ＯＣ（Ｏ）−ＮＨＸ９９１、−Ｏ−Ｃ（Ｏ）−ＮＸ９９２Ｘ９９３、−ＯＰ（Ｏ）（ＯＸ９９４）（ＯＸ９９５）、−ＯＳｉ（Ｘ９９６）（Ｘ９９７）（Ｘ９９８）、−ＯＳ（Ｏ₂）−Ｘ９９９、−ＮＨＣ（Ｏ）−Ｘ１０００、−ＮＸ１００１Ｃ（Ｏ）−Ｘ１００２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１００３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１００４、−ＮＨ−Ｃ（Ｏ）−ＮＸ１００５Ｘ１００６、−ＮＸ１００７−Ｃ（Ｏ）−Ｏ−Ｘ１００８、−ＮＸ１００９−Ｃ（Ｏ）−ＮＨ−Ｘ１０１０、−ＮＸ１０１１−Ｃ（Ｏ）−ＮＸ１０１２Ｘ１０１３、−ＮＨＳ（Ｏ₂）−Ｘ１０１４、−ＮＸ１０１５Ｓ（Ｏ₂）−Ｘ１０１６、−Ｓ−Ｘ１０１７、−Ｓ（Ｏ）−Ｘ１０１８、−Ｓ（Ｏ₂）−Ｘ１０１９、−Ｓ（Ｏ₂）ＮＨ−Ｘ１０２０、−Ｓ（Ｏ₂）ＮＸ１０２１Ｘ１０２２、−Ｓ（Ｏ₂）Ｏ−Ｘ１０２３、−Ｐ（Ｏ）（ＯＸ１０２４）（ＯＸ１０２５）、−Ｓｉ（Ｘ１０２６）（Ｘ１０２７）（Ｘ１０２８）"；
その際、Ｘ９７７、Ｘ９７８、Ｘ９７９、Ｘ９８０、Ｘ９８１、Ｘ９８２、Ｘ９８３、Ｘ９８４、Ｘ９８５、Ｘ９８６、Ｘ９８７、Ｘ９８８、Ｘ９８９、Ｘ９９０、Ｘ９９１、Ｘ９９２、Ｘ９９３、Ｘ９９４、Ｘ９９５、Ｘ９９６、Ｘ９９７、Ｘ９９８、Ｘ９９９、Ｘ１０００、Ｘ１００１、Ｘ１００２、Ｘ１００３、Ｘ１００４、Ｘ１００５、Ｘ１００６、Ｘ１００７、Ｘ１００８、Ｘ１００９、Ｘ１０１０、Ｘ１０１１、Ｘ１０１２、Ｘ１０１３、Ｘ１０１４、Ｘ１０１５、Ｘ１０１６、Ｘ１０１７、Ｘ１０１８、Ｘ１０１９、Ｘ１０２０、Ｘ１０２１、Ｘ１０２２、Ｘ１０２３、Ｘ１０２４、Ｘ１０２５、Ｘ１０２６、Ｘ１０２７、Ｘ１０２８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ９８３、Ｘ９８４及び／又はＸ９９２、Ｘ９９３及び／又はＸ１００５、Ｘ１００６及び／又はＸ１０１２、Ｘ１０１３及び／又はＸ１０２１、Ｘ１０２２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｌ）ＳＺ７、
その際、Ｚ７は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ１０２９、−ＮＸ１０３０Ｘ１０３１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ１０３２、−Ｃ（Ｏ）Ｏ−Ｘ１０３３、−Ｃ（Ｏ）ＮＨ−Ｘ１０３４、−Ｃ（Ｏ）ＮＸ１０３５Ｘ１０３６、−Ｏ−Ｘ１０３７、−Ｏ（−Ｘ１０３８−Ｏ）_i−Ｈ（ｉ＝１、２、３、４、５）、−Ｏ（−Ｘ１０３９−Ｏ）_i−Ｘ１０４０（ｉ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ１０４１、−ＯＣ（Ｏ）−Ｏ−Ｘ１０４２、−ＯＣ（Ｏ）−ＮＨＸ１０４３、−Ｏ−Ｃ（Ｏ）−ＮＸ１０４４Ｘ１０４５、−ＯＰ（Ｏ）（ＯＸ１０４６）（ＯＸ１０４７）、−ＯＳｉ（Ｘ１０４８）（Ｘ１０４９）（Ｘ１０５０）、−ＯＳ（Ｏ₂）−Ｘ１０５１、−ＮＨＣ（Ｏ）−Ｘ１０５２、−ＮＸ１０５３Ｃ（Ｏ）−Ｘ１０５４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１０５５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１０５６、−ＮＨ−Ｃ（Ｏ）−ＮＸ１０５７Ｘ１０５８、−ＮＸ１０５９−Ｃ（Ｏ）−Ｏ−Ｘ１０６０、−ＮＸ１０６１−Ｃ（Ｏ）−ＮＨ−Ｘ１０６２、−ＮＸ１０６３−Ｃ（Ｏ）−ＮＸ１０６４Ｘ１０６５、−ＮＨＳ（Ｏ₂）−Ｘ１０６６、−ＮＸ１０６７Ｓ（Ｏ₂）−Ｘ１０６８、−Ｓ−Ｘ１０６９、−Ｓ（Ｏ）−Ｘ１０７０、−Ｓ（Ｏ₂）−Ｘ１０７１、−Ｓ（Ｏ₂）ＮＨ−Ｘ１０７２、−Ｓ（Ｏ₂）ＮＸ１０７３Ｘ１０７４、−Ｓ（Ｏ₂）Ｏ−Ｘ１０７５、−Ｐ（Ｏ）（ＯＸ１０７６）（ＯＸ１０７７）、−Ｓｉ（Ｘ１０７８）（Ｘ１０７９）（Ｘ１０８０）"；
その際、Ｘ１０２９、Ｘ１０３０、Ｘ１０３１、Ｘ１０３２、Ｘ１０３３、Ｘ１０３４、Ｘ１０３５、Ｘ１０３６、Ｘ１０３７、Ｘ１０３８、Ｘ１０３９、Ｘ１０４０、Ｘ１０４１、Ｘ１０４２、Ｘ１０４３、Ｘ１０４４、Ｘ１０４５、Ｘ１０４６、Ｘ１０４７、Ｘ１０４８、Ｘ１０４９、Ｘ１０５０、Ｘ１０５１、Ｘ１０５２、Ｘ１０５３、Ｘ１０５４、Ｘ１０５５、Ｘ１０５６、Ｘ１０５７、Ｘ１０５８、Ｘ１０５９、Ｘ１０６０、Ｘ１０６１、Ｘ１０６２、Ｘ１０６３、Ｘ１０６４、Ｘ１０６５、Ｘ１０６６、Ｘ１０６７、Ｘ１０６８、Ｘ１０６９、Ｘ１０７０、Ｘ１０７１、Ｘ１０７２、Ｘ１０７３、Ｘ１０７４、Ｘ１０７５、Ｘ１０７６、Ｘ１０７７、Ｘ１０７８、Ｘ１０７９、Ｘ１０８０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ１０３５、Ｘ１０３６及び／又はＸ１０４４、Ｘ１０４５及び／又はＸ１０５７、Ｘ１０５８及び／又はＸ１０６４、Ｘ１０６５及び／又はＸ１０７３、Ｘ１０７４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ１０８１、−ＮＸ１０８２Ｘ１０８３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ１０８４、−Ｃ（Ｏ）Ｏ−Ｘ１０８５、−Ｃ（Ｏ）ＮＨ−Ｘ１０８６、−Ｃ（Ｏ）ＮＸ１０８７Ｘ１０８８、−Ｏ−Ｘ１０８９、−Ｏ（−Ｘ１０９０−Ｏ）_j−Ｈ（ｊ＝１、２、３、４、５）、−Ｏ（−Ｘ１０９１−Ｏ）_j−Ｘ１０９２（ｊ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ１０９３、−ＯＣ（Ｏ）−Ｏ−Ｘ１０９４、−ＯＣ（Ｏ）−ＮＨＸ１０９５、−Ｏ−Ｃ（Ｏ）−ＮＸ１０９６Ｘ１０９７、−ＯＰ（Ｏ）（ＯＸ１０９８）（ＯＸ１０９９）、−ＯＳｉ（Ｘ１１００）（Ｘ１１０１）（Ｘ１１０２）、−ＯＳ（Ｏ₂）−Ｘ１１０３、−ＮＨＣ（Ｏ）−Ｘ１１０４、−ＮＸ１１０５Ｃ（Ｏ）−Ｘ１１０６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１１０７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１１０８、−ＮＨ−Ｃ（Ｏ）−ＮＸ１１０９Ｘ１１１０、−ＮＸ１１１１−Ｃ（Ｏ）−Ｏ−Ｘ１１１２、−ＮＸ１１１３−Ｃ（Ｏ）−ＮＨ−Ｘ１１１４、−ＮＸ１１１５−Ｃ（Ｏ）−ＮＸ１１１６Ｘ１１１７、−ＮＨＳ（Ｏ₂）−Ｘ１１１８、−ＮＸ１１１９Ｓ（Ｏ₂）−Ｘ１１２０、−Ｓ−Ｘ１１２１、−Ｓ（Ｏ）−Ｘ１１２２、−Ｓ（Ｏ₂）−Ｘ１１２３、−Ｓ（Ｏ₂）ＮＨ−Ｘ１１２４、−Ｓ（Ｏ₂）ＮＸ１１２５Ｘ１１２６、−Ｓ（Ｏ₂）Ｏ−Ｘ１１２７、−Ｐ（Ｏ）（ＯＸ１１２８）（ＯＸ１１２９）、−Ｓｉ（Ｘ１１３０）（Ｘ１１３１）（Ｘ１１３２）"；
その際、Ｘ１０８１、Ｘ１０８２、Ｘ１０８３、Ｘ１０８４、Ｘ１０８５、Ｘ１０８６、Ｘ１０８７、Ｘ１０８８、Ｘ１０８９、Ｘ１０９０、Ｘ１０９１、Ｘ１０９２、Ｘ１０９３、Ｘ１０９４、Ｘ１０９５、Ｘ１０９６、Ｘ１０９７、Ｘ１０９８、Ｘ１０９９、Ｘ１１００、Ｘ１１０１、Ｘ１１０２、Ｘ１１０３、Ｘ１１０４、Ｘ１１０５、Ｘ１１０６、Ｘ１１０７、Ｘ１１０８、Ｘ１１０９、Ｘ１１１０、Ｘ１１１１、Ｘ１１１２、Ｘ１１１３、Ｘ１１１４、Ｘ１１１５、Ｘ１１１６、Ｘ１１１７、Ｘ１１１８、Ｘ１１１９、Ｘ１１２０、Ｘ１１２１、Ｘ１１２２、Ｘ１１２３、Ｘ１１２４、Ｘ１１２５、Ｘ１１２６、Ｘ１１２７、Ｘ１１２８、Ｘ１１２９、Ｘ１１３０、Ｘ１１３１、Ｘ１１３２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ１０８７、Ｘ１０８８及び／又はＸ１０９６、Ｘ１０９７及び／又はＸ１１０９、Ｘ１１１０及び／又はＸ１１１６、Ｘ１１１７及び／又はＸ１１２５、Ｘ１１２６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｍ）ＮＺ８Ｚ９、
その際、Ｚ８、Ｚ９は、互いに無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−Ｘ１１３３、−Ｃ（Ｏ）Ｏ−Ｘ１１３４、−Ｃ（Ｏ）−ＮＸ１１３５Ｘ１１３６、−Ｓ（Ｏ₂）−Ｘ１１３７、−Ｓ（Ｏ₂）Ｏ−Ｘ１１３８"；
その際、Ｘ１１３３、Ｘ１１３４、Ｘ１１３５、Ｘ１１３６、Ｘ１１３７、Ｘ１１３８は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｘ１１３５、Ｘ１１３６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ１１３９、−ＮＸ１１４０Ｘ１１４１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ１１４２、−Ｃ（Ｏ）Ｏ−Ｘ１１４３、−Ｃ（Ｏ）ＮＨ−Ｘ１１４４、−Ｃ（Ｏ）ＮＸ１１４５Ｘ１１４６、−Ｏ−Ｘ１１４７、−Ｏ（−Ｘ１１４８−Ｏ）_k−Ｈ（ｋ＝１、２、３、４、５）、−Ｏ（−Ｘ１１４９−Ｏ）_k−Ｘ１１５０（ｋ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ１１５１、−ＯＣ（Ｏ）−Ｏ−Ｘ１１５２、−ＯＣ（Ｏ）−ＮＨＸ１１５３、−Ｏ−Ｃ（Ｏ）−ＮＸ１１５４Ｘ１１５５、−ＯＰ（Ｏ）（ＯＸ１１５６）（ＯＸ１１５７）、−ＯＳｉ（Ｘ１１５８）（Ｘ１１５９）（Ｘ１１６０）、−ＯＳ（Ｏ₂）−Ｘ１１６１、−ＮＨＣ（Ｏ）−Ｘ１１６２、−ＮＸ１１６３Ｃ（Ｏ）−Ｘ１１６４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１１６５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１１６６、−ＮＨ−Ｃ（Ｏ）−ＮＸ１１６７Ｘ１１６８、−ＮＸ１１６９−Ｃ（Ｏ）−Ｏ−Ｘ１１７０、−ＮＸ１１７１−Ｃ（Ｏ）−ＮＨ−Ｘ１１７２、−ＮＸ１１７３−Ｃ（Ｏ）−ＮＸ１１７４Ｘ１１７５、−ＮＨＳ（Ｏ₂）−Ｘ１１７６、−ＮＸ１１７７Ｓ（Ｏ₂）−Ｘ１１７８、−Ｓ−Ｘ１１７９、−Ｓ（Ｏ）−Ｘ１１８０、−Ｓ（Ｏ₂）−Ｘ１１８１、−Ｓ（Ｏ₂）ＮＨ−Ｘ１１８２、−Ｓ（Ｏ₂）ＮＸ１１８３Ｘ１１８４、−Ｓ（Ｏ₂）Ｏ−Ｘ１１８５、−Ｐ（Ｏ）（ＯＸ１１８６）（ＯＸ１１８７）、−Ｓｉ（Ｘ１１８８）（Ｘ１１８９）（Ｘ１１９０）"；
その際、Ｘ１１３９、Ｘ１１４０、Ｘ１１４１、Ｘ１１４２、Ｘ１１４３、Ｘ１１４４、Ｘ１１４５、Ｘ１１４６、Ｘ１１４７、Ｘ１１４８、Ｘ１１４９、Ｘ１１５０、Ｘ１１５１、Ｘ１１５２、Ｘ１１５３、Ｘ１１５４、Ｘ１１５５、Ｘ１１５６、Ｘ１１５７、Ｘ１１５８、Ｘ１１５９、Ｘ１１６０、Ｘ１１６１、Ｘ１１６２、Ｘ１１６３、Ｘ１１６４、Ｘ１１６５、Ｘ１１６６、Ｘ１１６７、Ｘ１１６８、Ｘ１１６９、Ｘ１１７０、Ｘ１１７１、Ｘ１１７２、Ｘ１１７３、Ｘ１１７４、Ｘ１１７５、Ｘ１１７６、Ｘ１１７７、Ｘ１１７８、Ｘ１１７９、Ｘ１１８０、Ｘ１１８１、Ｘ１１８２、Ｘ１１８３、Ｘ１１８４、Ｘ１１８５、Ｘ１１８６、Ｘ１１８７、Ｘ１１８８、Ｘ１１８９、Ｘ１１９０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ１１４５、Ｘ１１４６及び／又はＸ１１５４、Ｘ１１５５及び／又はＸ１１６７、Ｘ１１６８及び／又はＸ１１７４、Ｘ１１７５及び／又はＸ１１８３、Ｘ１１８４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＸ１１９１、−ＮＸ１１９２Ｘ１１９３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｘ１１９４、−Ｃ（Ｏ）Ｏ−Ｘ１１９５、−Ｃ（Ｏ）ＮＨ−Ｘ１１９６、−Ｃ（Ｏ）ＮＸ１１９７Ｘ１１９８、−Ｏ−Ｘ１１９９、−Ｏ（−Ｘ１２００−Ｏ）_l−Ｈ（ｌ＝１、２、３、４、５）、−Ｏ（−Ｘ１２０１−Ｏ）_l−Ｘ１２０２（ｌ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｘ１２０３、−ＯＣ（Ｏ）−Ｏ−Ｘ１２０４、−ＯＣ（Ｏ）−ＮＨＸ１２０５、−Ｏ−Ｃ（Ｏ）−ＮＸ１２０６Ｘ１２０７、−ＯＰ（Ｏ）（ＯＸ１２０８）（ＯＸ１２０９）、−ＯＳｉ（Ｘ１２１０）（Ｘ１２１１）（Ｘ１２１２）、−ＯＳ（Ｏ₂）−Ｘ１２１３、−ＮＨＣ（Ｏ）−Ｘ１２１４、−ＮＸ１２１５Ｃ（Ｏ）−Ｘ１２１６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｘ１２１７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｘ１２１８、−ＮＨ−Ｃ（Ｏ）−ＮＸ１２１９Ｘ１２２０、−ＮＸ１２２１−Ｃ（Ｏ）−Ｏ−Ｘ１２２２、−ＮＸ１２２３−Ｃ（Ｏ）−ＮＨ−Ｘ１２２４、−ＮＸ１２２５−Ｃ（Ｏ）−ＮＸ１２２６Ｘ１２２７、−ＮＨＳ（Ｏ₂）−Ｘ１２２８、−ＮＸ１２２９Ｓ（Ｏ₂）−Ｘ１２３０、−Ｓ−Ｘ１２３１、−Ｓ（Ｏ）−Ｘ１２３２、−Ｓ（Ｏ₂）−Ｘ１２３３、−Ｓ（Ｏ₂）ＮＨ−Ｘ１２３４、−Ｓ（Ｏ₂）ＮＸ１２３５Ｘ１２３６、−Ｓ（Ｏ₂）Ｏ−Ｘ１２３７、−Ｐ（Ｏ）（ＯＸ１２３８）（ＯＸ１２３９）、−Ｓｉ（Ｘ１２４０）（Ｘ１２４１）（Ｘ１２４２）"；
その際、Ｘ１１９１、Ｘ１１９２、Ｘ１１９３、Ｘ１１９４、Ｘ１１９５、Ｘ１１９６、Ｘ１１９７、Ｘ１１９８、Ｘ１１９９、Ｘ１２００、Ｘ１２０１、Ｘ１２０２、Ｘ１２０３、Ｘ１２０４、Ｘ１２０５、Ｘ１２０６、Ｘ１２０７、Ｘ１２０８、Ｘ１２０９、Ｘ１２１０、Ｘ１２１１、Ｘ１２１２、Ｘ１２１３、Ｘ１２１４、Ｘ１２１５、Ｘ１２１６、Ｘ１２１７、Ｘ１２１８、Ｘ１２１９、Ｘ１２２０、Ｘ１２２１、Ｘ１２２２、Ｘ１２２３、Ｘ１２２４、Ｘ１２２５、Ｘ１２２６、Ｘ１２２７、Ｘ１２２８、Ｘ１２２９、Ｘ１２３０、Ｘ１２３１、Ｘ１２３２、Ｘ１２３３、Ｘ１２３４、Ｘ１２３５、Ｘ１２３６、Ｘ１２３７、Ｘ１２３８、Ｘ１２３９、Ｘ１２４０、Ｘ１２４１、Ｘ１２４２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＸ１１９７、Ｘ１１９８及び／又はＸ１２０６、Ｘ１２０７及び／又はＸ１２１９、Ｘ１２２０及び／又はＸ１２２６、Ｘ１２２７及び／又はＸ１２３５、Ｘ１２３６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
又は
（Ｂ）
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、"置換されたヘテロアリール"であり、その際、"置換されたヘテロアリール"は、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されている：
（ａ）"アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、−ＮＨ−Ｖ１、−Ｎ（アルキル）₂、−ＮＨＣ（Ｏ）−アルキル、−ＮＨＣ（Ｏ）−シクロアルキル、−ＮＨＣ（Ｏ）−ヘテロシクリル、−ＮＨＣ（Ｏ）−アリール、−ＮＨＣ（Ｏ）−ヘテロアリール、−ＮＨＣ（Ｏ）−アリールアルキル、−ＮＨＣ（Ｏ）−ヘテロアリールアルキル、−ＮＨＳ（Ｏ₂）−アルキル、−ＮＨＳ（Ｏ₂）−シクロアルキル、−ＮＨＳ（Ｏ₂）−ヘテロシクリル、−ＮＨＳ（Ｏ₂）−アリール、−ＮＨＳ（Ｏ₂）−ヘテロアリール、−ＮＨＳ（Ｏ₂）−アリールアルキル、−ＮＨＳ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ−アルキル、−Ｓ−アリール、−Ｓ−ヘテロアリール、−Ｏ−アルキル、−Ｏ−シクロアルキル、−Ｏ−シクロアルキルアルキル、−Ｏ−アリール、−Ｏ−アリールアルキル、−Ｏ−ヘテロアリール、−Ｏ−ヘテロアリールアルキル、−Ｏ−ヘテロシクリルアルキル、−ＯＣ（Ｏ）−アルキル、−ＯＣ（Ｏ）−シクロアルキル、−ＯＣ（Ｏ）−ヘテロシクリル、−ＯＣ（Ｏ）−アリール、−ＯＣ（Ｏ）−ヘテロアリール、−ＯＣ（Ｏ）−アリールアルキル、−ＯＣ（Ｏ）−ヘテロアリールアルキル、−ＯＳ（Ｏ₂）−アルキル、−ＯＳ（Ｏ₂）−シクロアルキル、−ＯＳ（Ｏ₂）−ヘテロシクリル、−ＯＳ（Ｏ₂）−アリール、−ＯＳ（Ｏ₂）−ヘテロアリール、−ＯＳ（Ｏ₂）−アリールアルキル、−ＯＳ（Ｏ₂）−ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）Ｏ−Ｖ２、−Ｃ（Ｏ）ＮＨ−Ｖ３、−Ｃ（Ｏ）Ｎ（アルキル）₂、−Ｃ（Ｏ）Ｎ（シクロアルキル）₂、−Ｃ（Ｏ）Ｎ（アリール）₂、−Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、−Ｓ（Ｏ₂）ＮＨ−アルキル、−Ｓ（Ｏ₂）ＮＨ−アリール、−Ｓ（Ｏ₂）ＮＨ−ヘテロアリール、−Ｓ（Ｏ₂）ＮＨ−アリールアルキル、Ｓ（Ｏ₂）Ｏ−アルキル、−Ｓ（Ｏ₂）Ｏ−アリール、−Ｓ（Ｏ₂）Ｏ−アリールアルキル"；
その際、Ｖ１、Ｖ２、Ｖ３は、互いに無関係に"アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択される；
但し、置換基群（ａ）の上記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されている：
（ｉ）"Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｎ₃、−ＮＨ−シクロアルキル、−ＮＨ−シクロアルキルアルキル、−ＮＨ−ヘテロアリール、−ＮＨ−ヘテロアリールアルキル、−ＮＨ−アリールアルキル、−ＮＨ−ヘテロシクリル、−ＮＨ−ヘテロシクリルアルキル、−ＮＶ４Ｖ５、−Ｓ−シクロアルキル、−Ｓ−シクロアルキルアルキル、−Ｓ−アリール、−Ｓ−アリールアルキル、−Ｓ−ヘテロアリール、−Ｓ−ヘテロアリールアルキル、−Ｓ−ヘテロシクリル、−Ｓ−ヘテロシクリルアルキル、−Ｏ−シクロアルキル、−Ｏ−シクロアルキルアルキル、−Ｏ−アリールアルキル、−Ｏ−ヘテロアリール、−Ｏ−ヘテロアリールアルキル、−Ｏ−ヘテロシクリル、−Ｏ−ヘテロシクリルアルキル、−Ｏ（−Ｖ６−Ｏ）_p−Ｈ（ｐ＝１、２、３、４、５）、−Ｏ（−Ｖ７−Ｏ）_p−Ｖ８（ｐ＝１、２、３、４、５）、−ＯＰ（Ｏ）（ＯＶ９）（ＯＶ１０）、−Ｃ（Ｏ）Ｏ−Ｖ１１、−Ｃ（Ｏ）ＮＨ₂、−Ｃ（Ｏ）ＮＨ−Ｖ１２、−Ｃ（Ｏ）ＮＶ１３Ｖ１４、−Ｓ（Ｏ₂）−Ｖ１５、−Ｐ（Ｏ）（ＯＨ）₂、−Ｐ（Ｏ）（ＯＶ１６）（ＯＶ１７）、−Ｓｉ（Ｖ１８）（Ｖ１９）（Ｖ２０）、−Ｏ−Ｓｉ（Ｖ２１）（Ｖ２２）（Ｖ２３）、−Ｏ−Ｃ（Ｏ）−Ｏ−Ｖ２４、−Ｏ−Ｃ（Ｏ）−ＮＨ−Ｖ２５、−Ｏ−Ｃ（Ｏ）−ＮＶ２６Ｖ２７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ２８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ２９、−ＮＨ−Ｃ（Ｏ）−ＮＶ３０Ｖ３１、−ＮＶ３２−Ｃ（Ｏ）−Ｏ−Ｖ３３、−ＮＶ３４−Ｃ（Ｏ）−ＮＨ−Ｖ３５、−ＮＶ３６−Ｃ（Ｏ）−ＮＶ３７Ｖ３８、−ＮＶ３９−Ｓ（Ｏ₂）−Ｖ４０、−ＮＨ−Ｓ（Ｏ₂）−Ｖ４１、−Ｏ−Ｓ（Ｏ₂）−Ｖ４２、−ＮＨ−Ｃ（Ｏ）−Ｖ４３、−ＮＶ４４−Ｃ（Ｏ）−Ｖ４５、−Ｃ（Ｏ）−Ｖ４６、−ＯＣ（Ｏ）−Ｖ４７、−Ｓ（Ｏ）−Ｖ４８、−Ｓ（Ｏ₂）−ＮＨＶ４９、−Ｓ（Ｏ₂）−ＮＶ５０Ｖ５１、−Ｓ（Ｏ₂）−ＯＶ５２"；
但し、更に、"−Ｎ（アルキル）₂"は、以下の置換基群（ｂ）から選択される少なくとも１つの置換基によって更に置換されている；
その際、Ｖ４、Ｖ５、Ｖ６、Ｖ７、Ｖ８、Ｖ９、Ｖ１０、Ｖ１１、Ｖ１２、Ｖ１３、Ｖ１４、Ｖ１５、Ｖ１６、Ｖ１７、Ｖ１８、Ｖ１９、Ｖ２０、Ｖ２１、Ｖ２２、Ｖ２３、Ｖ２４、Ｖ２５、Ｖ２６、Ｖ２７、Ｖ２８、Ｖ２９、Ｖ３０、Ｖ３１、Ｖ３２、Ｖ３３、Ｖ３４、Ｖ３５、Ｖ３６、Ｖ３７、Ｖ３８、Ｖ３９、Ｖ４０、Ｖ４１、Ｖ４２、Ｖ４３、Ｖ４４、Ｖ４５、Ｖ４６、Ｖ４７、Ｖ４８、Ｖ４９、Ｖ５０、Ｖ５１、Ｖ５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｖ１３、Ｖ１４及び／又はＶ２６、Ｖ２７及び／又はＶ３０、Ｖ３１及び／又はＶ３７、Ｖ３８及び／又はＶ５０、Ｖ５１は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により付加的に、基Ｚ３、Ｚ４の一方は、もしくは付加的に、両方の基Ｚ３、Ｚ４は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｂ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ５３、−ＮＶ５４Ｖ５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ５６、−Ｃ（Ｏ）Ｏ−Ｖ５７、−Ｃ（Ｏ）ＮＨ−Ｖ５８、−Ｃ（Ｏ）ＮＶ５９Ｖ６０、−Ｏ−Ｖ６１、−Ｏ（−Ｖ６２−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｖ６３−Ｏ）_r−Ｖ６４（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ６５、−ＯＣ（Ｏ）−Ｏ−Ｖ６６、−ＯＣ（Ｏ）−ＮＨＶ６７、−Ｏ−Ｃ（Ｏ）−ＮＶ６８Ｖ６９、−ＯＰ（Ｏ）（ＯＶ７０）（ＯＶ７１）、−ＯＳｉ（Ｖ７２）（Ｖ７３）（Ｖ７４）、−ＯＳ（Ｏ₂）−Ｖ７５、−ＮＨＣ（Ｏ）−Ｖ７６、−ＮＶ７７Ｃ（Ｏ）−Ｖ７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ８０、−ＮＨ−Ｃ（Ｏ）−ＮＶ８１Ｖ８２、−ＮＶ８３−Ｃ（Ｏ）−Ｏ−Ｖ８４、−ＮＶ８５−Ｃ（Ｏ）−ＮＨ−Ｖ８６、−ＮＶ８７−Ｃ（Ｏ）−ＮＶ８８Ｖ８９、−ＮＨＳ（Ｏ₂）−Ｖ９０、−ＮＶ９１Ｓ（Ｏ₂）−Ｖ９２、−Ｓ−Ｖ９３、−Ｓ（Ｏ）−Ｖ９４、−Ｓ（Ｏ₂）−Ｖ９５、−Ｓ（Ｏ₂）ＮＨ−Ｖ９６、−Ｓ（Ｏ₂）ＮＶ９７Ｖ９８、−Ｓ（Ｏ₂）Ｏ−Ｖ９９、−Ｐ（Ｏ）（ＯＶ１００）（ＯＶ１０１）、−Ｓｉ（Ｖ１０２）（Ｖ１０３）（Ｖ１０４）"；
その際、Ｖ５３、Ｖ５４、Ｖ５５、Ｖ５６、Ｖ５７、Ｖ５８、Ｖ５９、Ｖ６０、Ｖ６１、Ｖ６２、Ｖ６３、Ｖ６４、Ｖ６５、Ｖ６６、Ｖ６７、Ｖ６８、Ｖ６９、Ｖ７０、Ｖ７１、Ｖ７２、Ｖ７３、Ｖ７４、Ｖ７５、Ｖ７６、Ｖ７７、Ｖ７８、Ｖ７９、Ｖ８０、Ｖ８１、Ｖ８２、Ｖ８３、Ｖ８４、Ｖ８５、Ｖ８６、Ｖ８７、Ｖ８８、Ｖ８９、Ｖ９０、Ｖ９１、Ｖ９２、Ｖ９３、Ｖ９４、Ｖ９５、Ｖ９６、Ｖ９７、Ｖ９８、Ｖ９９、Ｖ１００、Ｖ１０１、Ｖ１０２、Ｖ１０３、Ｖ１０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ５９、Ｖ６０及び／又はＶ６８、Ｖ６９及び／又はＶ８１、Ｖ８２及び／又はＶ８８、Ｖ８９及び／又はＶ９７、Ｖ９８は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｂ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ１０５、−ＮＶ１０６Ｖ１０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ１０８、−Ｃ（Ｏ）Ｏ−Ｖ１０９、−Ｃ（Ｏ）ＮＨ−Ｖ１１０、−Ｃ（Ｏ）ＮＶ１１１Ｖ１１２、−Ｏ−Ｖ１１３、−Ｏ（−Ｖ１１４−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ｖ１１５−Ｏ）_s−Ｖ１１６（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ１１７、−ＯＣ（Ｏ）−Ｏ−Ｖ１１８、−ＯＣ（Ｏ）−ＮＨＶ１１９、−Ｏ−Ｃ（Ｏ）−ＮＶ１２０Ｖ１２１、−ＯＰ（Ｏ）（ＯＶ１２２）（ＯＶ１２３）、−ＯＳｉ（Ｖ１２４）（Ｖ１２５）（Ｖ１２６）、−ＯＳ（Ｏ₂）−Ｖ１２７、−ＮＨＣ（Ｏ）−Ｖ１２８、−ＮＶ１２９Ｃ（Ｏ）−Ｖ１３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１３２、−ＮＨ−Ｃ（Ｏ）−ＮＶ１３３Ｖ１３４、−ＮＶ１３５−Ｃ（Ｏ）−Ｏ−Ｖ１３６、−ＮＶ１３７−Ｃ（Ｏ）−ＮＨ−Ｖ１３８、−ＮＶ１３９−Ｃ（Ｏ）−ＮＶ１４０Ｖ１４１、−ＮＨＳ（Ｏ₂）−Ｖ１４２、−ＮＶ１４３Ｓ（Ｏ₂）−Ｖ１４４、−Ｓ−Ｖ１４５、−Ｓ（Ｏ）−Ｖ１４６、−Ｓ（Ｏ₂）−Ｖ１４７、−Ｓ（Ｏ₂）ＮＨ−Ｖ１４８、−Ｓ（Ｏ₂）ＮＶ１４９Ｖ１５０、−Ｓ（Ｏ₂）Ｏ−Ｖ１５１、−Ｐ（Ｏ）（ＯＶ１５２）（ＯＶ１５３）、−Ｓｉ（Ｖ１５４）（Ｖ１５５）（Ｖ１５６）"；
その際、Ｖ１０５、Ｖ１０６、Ｖ１０７、Ｖ１０８、Ｖ１０９、Ｖ１１０、Ｖ１１１、Ｖ１１２、Ｖ１１３、Ｖ１１４、Ｖ１１５、Ｖ１１６、Ｖ１１７、Ｖ１１８、Ｖ１１９、Ｖ１２０、Ｖ１２１、Ｖ１２２、Ｖ１２３、Ｖ１２４、Ｖ１２５、Ｖ１２６、Ｖ１２７、Ｖ１２８、Ｖ１２９、Ｖ１３０、Ｖ１３１、Ｖ１３２、Ｖ１３３、Ｖ１３４、Ｖ１３５、Ｖ１３６、Ｖ１３７、Ｖ１３８、Ｖ１３９、Ｖ１４０、Ｖ１４１、Ｖ１４２、Ｖ１４３、Ｖ１４４、Ｖ１４５、Ｖ１４６、Ｖ１４７、Ｖ１４８、Ｖ１４９、Ｖ１５０、Ｖ１５１、Ｖ１５２、Ｖ１５３、Ｖ１５４、Ｖ１５５、Ｖ１５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ１１１、Ｖ１１２及び／又はＶ１２０、Ｖ１２１及び／又はＶ１３３、Ｖ１３４及び／又はＶ１４０、Ｖ１４１及び／又はＶ１４９、Ｖ１５０は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）及び／又は置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ１５７、−ＮＶ１５８Ｖ１５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ１６０、−Ｃ（Ｏ）Ｏ−Ｖ１６１、−Ｃ（Ｏ）ＮＨ−Ｖ１６２、−Ｃ（Ｏ）ＮＶ１６３Ｖ１６４、−Ｏ−Ｖ１６５、−Ｏ（−Ｖ１６６−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｖ１６７−Ｏ）_t−Ｖ１６８（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ１６９、−ＯＣ（Ｏ）−Ｏ−Ｖ１７０、−ＯＣ（Ｏ）−ＮＨＶ１７１、−Ｏ−Ｃ（Ｏ）−ＮＶ１７２Ｖ１７３、−ＯＰ（Ｏ）（ＯＶ１７４）（ＯＶ１７５）、−ＯＳｉ（Ｖ１７６）（Ｖ１７７）（Ｖ１７８）、−ＯＳ（Ｏ₂）−Ｖ１７９、−ＮＨＣ（Ｏ）−Ｖ１８０、−ＮＶ１８１Ｃ（Ｏ）−Ｖ１８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１８４、−ＮＨ−Ｃ（Ｏ）−ＮＶ１８５Ｖ１８６、−ＮＶ１８７−Ｃ（Ｏ）−Ｏ−Ｖ１８８、−ＮＶ１８９−Ｃ（Ｏ）−ＮＨ−Ｖ１９０、−ＮＶ１９１−Ｃ（Ｏ）−ＮＶ１９２Ｖ１９３、−ＮＨＳ（Ｏ₂）−Ｖ１９４、−ＮＶ１９５Ｓ（Ｏ₂）−Ｖ１９６、−Ｓ−Ｖ１９７、−Ｓ（Ｏ）−Ｖ１９８、−Ｓ（Ｏ₂）−Ｖ１９９、−Ｓ（Ｏ₂）ＮＨ−Ｖ２００、−Ｓ（Ｏ₂）ＮＶ２０１Ｖ２０２、−Ｓ（Ｏ₂）Ｏ−Ｖ２０３、−Ｐ（Ｏ）（ＯＶ２０４）（ＯＶ２０５）、−Ｓｉ（Ｖ２０６）（Ｖ２０７）（Ｖ２０８）"；
その際、Ｖ１５７、Ｖ１５８、Ｖ１５９、Ｖ１６０、Ｖ１６１、Ｖ１６２、Ｖ１６３、Ｖ１６４、Ｖ１６５、Ｖ１６６、Ｖ１６７、Ｖ１６８、Ｖ１６９、Ｖ１７０、Ｖ１７１、Ｖ１７２、Ｖ１７３、Ｖ１７４、Ｖ１７５、Ｖ１７６、Ｖ１７７、Ｖ１７８、Ｖ１７９、Ｖ１８０、Ｖ１８１、Ｖ１８２、Ｖ１８３、Ｖ１８４、Ｖ１８５、Ｖ１８６、Ｖ１８７、Ｖ１８８、Ｖ１８９、Ｖ１９０、Ｖ１９１、Ｖ１９２、Ｖ１９３、Ｖ１９４、Ｖ１９５、Ｖ１９６、Ｖ１９７、Ｖ１９８、Ｖ１９９、Ｖ２００、Ｖ２０１、Ｖ２０２、Ｖ２０３、Ｖ２０４、Ｖ２０５、Ｖ２０６、Ｖ２０７、Ｖ２０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ１６３、Ｖ１６４及び／又はＶ１７２、Ｖ１７３及び／又はＶ１８５、Ｖ１８６及び／又はＶ１９２、Ｖ１９３及び／又はＶ２０１、Ｖ２０２は、一緒になって、"ヘテロシクリル"を形成することもできる；
又は、
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、"置換されたヘテロアリール"であり、その際、"置換されたヘテロアリール"は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されている：
（ｃ）"Ｃ₉〜Ｃ₃₀−アルキル、−ＮＶ２０９Ｖ２１０、−ＮＨ−Ｃ₉〜Ｃ₃₀−アルキル、−ＮＨＣ（Ｏ）−シクロアルキルアルキル、−ＮＨＣ（Ｏ）−ヘテロシクリルアルキル、−ＮＨＣ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−ＮＶ２１１Ｃ（Ｏ）−Ｖ２１２、−ＮＶ２１３Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−ＮＨＣ（Ｏ）−ＯＶ２１４、−ＮＶ２１５Ｃ（Ｏ）−ＯＶ２１６、−ＮＨＣ（Ｏ）−ＮＨＶ２１７、−ＮＨＣ（Ｏ）−ＮＶ２１８Ｖ２１９、−ＮＶ２２０Ｃ（Ｏ）−ＮＨＶ２２１、−ＮＶ２２２Ｃ（Ｏ）−ＮＶ２２３Ｖ２２４、−ＮＨＳ（Ｏ₂）−シクロアルキルアルキル、−ＮＨＳ（Ｏ₂）−ヘテロシクリルアルキル、−ＮＶ２２５Ｓ（Ｏ₂）−Ｖ２２６、−Ｏ−ヘテロシクリル、−Ｏ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ−シクロアルキル、−Ｓ−ヘテロシクリル、−Ｓ−アリールアルキル、−Ｓ−ヘテロアリールアルキル、−Ｓ−シクロアルキルアルキル、−Ｓ−ヘテロシクリルアルキル、−Ｓ−Ｃ₉〜Ｃ₃₀−アルキル、−ＯＣ（Ｏ）−シクロアルキルアルキル、−ＯＣ（Ｏ）−ヘテロシクリルアルキル、−ＯＣ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−ＯＣ（Ｏ）−ＯＶ２２７、−ＯＣ（Ｏ）−ＮＨＶ２２８、−ＯＣ（Ｏ）−ＮＶ２２９Ｖ２３０、−ＯＰ（Ｏ）（ＯＶ２３１）（ＯＶ２３２）、−ＯＳ（Ｏ₂）−シクロアルキルアルキル、−ＯＳ（Ｏ₂）−ヘテロシクリルアルキル、−ＯＳ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）Ｏ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）ＮＨ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）ＮＶ２３３Ｖ２３４、−Ｃ（Ｏ）ＮＨ−ＯＶ２３５、−Ｃ（Ｏ）ＮＶ２３６−ＯＶ２３７、−Ｃ（Ｏ）ＮＨ−ＮＶ２３８Ｖ２３９、−Ｃ（Ｏ）ＮＶ２４０−ＮＶ２４１Ｖ２４２、−Ｓ（Ｏ）−Ｖ２４３、−Ｓ（Ｏ₂）−Ｖ２４４、−Ｓ（Ｏ₂）ＮＨ−シクロアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロシクリル、−Ｓ（Ｏ₂）ＮＨ−ヘテロアリールアルキル、−Ｓ（Ｏ₂）ＮＨ−シクロアルキルアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）ＮＨ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）Ｏ−シクロアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロシクリル、−Ｓ（Ｏ₂）Ｏ−ヘテロアリール、−Ｓ（Ｏ₂）Ｏ−ヘテロアリールアルキル、−Ｓ（Ｏ₂）Ｏ−シクロアルキルアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）Ｏ−Ｃ₉〜Ｃ₃₀−アルキル、−Ｐ（Ｏ）（ＯＨ）₂、−Ｐ（Ｏ）（ＯＶ２４５）（ＯＶ２４６）、−Ｓｉ（Ｖ２４７）（Ｖ２４８）（Ｖ２４７）、−Ｏ−Ｓｉ（Ｖ２５０）（Ｖ２５１）（Ｖ２５２）"；
その際、Ｖ２０９、Ｖ２１０、Ｖ２１１、Ｖ２１２、Ｖ２１３、Ｖ２１４、Ｖ２１５、Ｖ２１６、Ｖ２１７、Ｖ２１８、Ｖ２１９、Ｖ２２０、Ｖ２２１、Ｖ２２２、Ｖ２２３、Ｖ２２４、Ｖ２２５、Ｖ２２６、Ｖ２２７、Ｖ２２８、Ｖ２２９、Ｖ２３０、Ｖ２３１、Ｖ２３２、Ｖ２３３、Ｖ２３４、Ｖ２３５、Ｖ２３６、Ｖ２３７、Ｖ２３８、Ｖ２３９、Ｖ２４０、Ｖ２４１、Ｖ２４２、Ｖ２４３、Ｖ２４４、Ｖ２４５、Ｖ２４６、Ｖ２４７、Ｖ２４８、Ｖ２４９、Ｖ２５０、Ｖ２５１、Ｖ２５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｖ２１８、Ｖ２１９及び／又はＶ２２３、Ｖ２２４及び／又はＶ２２９、Ｖ２３０及び／又はＶ２３３、Ｖ２３４及び／又はＶ２３８、Ｖ２３９及び／又はＶ２４１、Ｖ２４２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
但し、置換基"−Ｎ（アルキル）₂"、"−Ｃ（Ｏ）Ｎ（アルキル）₂"、"−Ｃ（Ｏ）Ｎ（シクロアルキル）₂"、"−Ｃ（Ｏ）Ｎ（アリール）₂"、"−Ｃ（Ｏ）Ｎ（ヘテロアリール）₂"は、以下の置換基群（ｉ）から選択される少なくとも１つの置換基によって更に置換されている；
その際、場合により、置換基群（ｃ）の前記の置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ２５３、−ＮＶ２５４Ｖ２５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ２５６、−Ｃ（Ｏ）Ｏ−Ｖ２５７、−Ｃ（Ｏ）ＮＨ−Ｖ２５８、−Ｃ（Ｏ）ＮＶ２５９Ｖ２６０、−Ｏ−Ｖ２６１、−Ｏ（−Ｖ２６２−Ｏ）_u−Ｈ（ｕ＝１、２、３、４、５）、−Ｏ（−Ｖ２６３−Ｏ）_u−Ｖ２６４（ｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ２６５、−ＯＣ（Ｏ）−Ｏ−Ｖ２６６、−ＯＣ（Ｏ）−ＮＨＶ２６７、−Ｏ−Ｃ（Ｏ）−ＮＶ２６８Ｖ２６９、−ＯＰ（Ｏ）（ＯＶ２７０）（ＯＶ２７１）、−ＯＳｉ（Ｖ２７２）（Ｖ２７３）（Ｖ２７４）、−ＯＳ（Ｏ₂）−Ｖ２７５、−ＮＨＣ（Ｏ）−Ｖ２７６、−ＮＶ２７７Ｃ（Ｏ）−Ｖ２７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ２７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ２８０、−ＮＨ−Ｃ（Ｏ）−ＮＶ２８１Ｖ２８２、−ＮＶ２８３−Ｃ（Ｏ）−Ｏ−Ｖ２８４、−ＮＶ２８５−Ｃ（Ｏ）−ＮＨ−Ｖ２８６、−ＮＶ２８７−Ｃ（Ｏ）−ＮＶ２８８Ｖ２８９、−ＮＨＳ（Ｏ₂）−Ｖ２９０、−ＮＶ２９１Ｓ（Ｏ₂）−Ｖ２９２、−Ｓ−Ｖ２９３、−Ｓ（Ｏ）−Ｖ２９４、−Ｓ（Ｏ₂）−Ｖ２９５、−Ｓ（Ｏ₂）ＮＨ−Ｖ２９６、−Ｓ（Ｏ₂）ＮＶ２９７Ｖ２９８、−Ｓ（Ｏ₂）Ｏ−Ｖ２９９、−Ｐ（Ｏ）（ＯＶ３００）（ＯＶ３０１）、−Ｓｉ（Ｖ３０２）（Ｖ３０３）（Ｖ３０４）"；
その際、Ｖ２５３、Ｖ２５４、Ｖ２５５、Ｖ２５６、Ｖ２５７、Ｖ２５８、Ｖ２５９、Ｖ２６０、Ｖ２６１、Ｖ２６２、Ｖ２６３、Ｖ２６４、Ｖ２６５、Ｖ２６６、Ｖ２６７、Ｖ２６８、Ｖ２６９、Ｖ２７０、Ｖ２７１、Ｖ２７２、Ｖ２７３、Ｖ２７４、Ｖ２７５、Ｖ２７６、Ｖ２７７、Ｖ２７８、Ｖ２７９、Ｖ２８０、Ｖ２８１、Ｖ２８２、Ｖ２８３、Ｖ２８４、Ｖ２８５、Ｖ２８６、Ｖ２８７、Ｖ２８８、Ｖ２８９、Ｖ２９０、Ｖ２９１、Ｖ２９２、Ｖ２９３、Ｖ２９４、Ｖ２９５、Ｖ２９６、Ｖ２９７、Ｖ２９８、Ｖ２９９、Ｖ３００、Ｖ３０１、Ｖ３０２、Ｖ３０３、Ｖ３０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ２５９、Ｖ２６０及び／又はＶ２６８、Ｖ２６９及び／又はＶ２８１、Ｖ２８２及び／又はＶ２８８、Ｖ２８９及び／又はＶ２９７、Ｖ２９８は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により付加的に、基Ｚ３、Ｚ３の一方は、もしくは付加的に、両方の基Ｚ３、Ｚ４は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｄ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ３０５、−ＮＶ３０６Ｖ３０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ３０８、−Ｃ（Ｏ）Ｏ−Ｖ３０９、−Ｃ（Ｏ）ＮＨ−Ｖ３１０、−Ｃ（Ｏ）ＮＶ３１１Ｖ３１２、−Ｏ−Ｖ３１３、−Ｏ（−Ｖ３１４−Ｏ）_v−Ｈ（ｖ＝１、２、３、４、５）、−Ｏ（−Ｖ３１５−Ｏ）_v−Ｖ３１６（ｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ３１７、−ＯＣ（Ｏ）−Ｏ−Ｖ３１８、−ＯＣ（Ｏ）−ＮＨＶ３１９、−Ｏ−Ｃ（Ｏ）−ＮＶ３２０Ｖ３２１、−ＯＰ（Ｏ）（ＯＶ３２２）（ＯＶ３２３）、−ＯＳｉ（Ｖ３２４）（Ｖ３２５）（Ｖ３２６）、−ＯＳ（Ｏ₂）−Ｖ３２７、−ＮＨＣ（Ｏ）−Ｖ３２８、−ＮＶ３２９Ｃ（Ｏ）−Ｖ３３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ３３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ３３２、−ＮＨ−Ｃ（Ｏ）−ＮＶ３３３Ｖ３３４、−ＮＶ３３５−Ｃ（Ｏ）−Ｏ−Ｖ３３６、−ＮＶ３３７−Ｃ（Ｏ）−ＮＨ−Ｖ３３８、−ＮＶ３３９−Ｃ（Ｏ）−ＮＶ３４０Ｖ３４１、−ＮＨＳ（Ｏ₂）−Ｖ３４２、−ＮＶ３４３Ｓ（Ｏ₂）−Ｖ３４４、−Ｓ−Ｖ３４５、−Ｓ（Ｏ）−Ｖ３４６、−Ｓ（Ｏ₂）−Ｖ３４７、−Ｓ（Ｏ₂）ＮＨ−Ｖ３４８、−Ｓ（Ｏ₂）ＮＶ３４９Ｖ３５０、−Ｓ（Ｏ₂）Ｏ−Ｖ３５１、−Ｐ（Ｏ）（ＯＶ３５２）（ＯＶ３５３）、−Ｓｉ（Ｖ３５４）（Ｖ３５５）（Ｖ３５６）"；
その際、Ｖ３０５、Ｖ３０６、Ｖ３０７、Ｖ３０８、Ｖ３０９、Ｖ３１０、Ｖ３１１、Ｖ３１２、Ｖ３１３、Ｖ３１４、Ｖ３１５、Ｖ３１６、Ｖ３１７、Ｖ３１８、Ｖ３１９、Ｖ３２０、Ｖ３２１、Ｖ３２２、Ｖ３２３、Ｖ３２４、Ｖ３２５、Ｖ３２６、Ｖ３２７、Ｖ３２８、Ｖ３２９、Ｖ３３０、Ｖ３３１、Ｖ３３２、Ｖ３３３、Ｖ３３４、Ｖ３３５、Ｖ３３６、Ｖ３３７、Ｖ３３８、Ｖ３３９、Ｖ３４０、Ｖ３４１、Ｖ３４２、Ｖ３４３、Ｖ３４４、Ｖ３４５、Ｖ３４６、Ｖ３４７、Ｖ３４８、Ｖ３４９、Ｖ３５０、Ｖ３５１、Ｖ３５２、Ｖ３５３、Ｖ３５４、Ｖ３５５、Ｖ３５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ３１１、Ｖ３１２及び／又はＶ３２０、Ｖ３２１及び／又はＶ３３３、Ｖ３３４及び／又はＶ３４０、Ｖ３４１及び／又はＶ３４９、Ｖ３５０は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｄ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ３５７、−ＮＶ３５８Ｖ３５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ３６０、−Ｃ（Ｏ）Ｏ−Ｖ３６１、−Ｃ（Ｏ）ＮＨ−Ｖ３６２、−Ｃ（Ｏ）ＮＶ３６３Ｖ３６４、−Ｏ−Ｖ３６５、−Ｏ（−Ｖ３６６−Ｏ）_w−Ｈ（ｗ＝１、２、３、４、５）、−Ｏ（−Ｖ３６７−Ｏ）_w−Ｖ３６８（ｗ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ３６９、−ＯＣ（Ｏ）−Ｏ−Ｖ３７０、−ＯＣ（Ｏ）−ＮＨＶ３７１、−Ｏ−Ｃ（Ｏ）−ＮＶ３７２Ｖ３７３、−ＯＰ（Ｏ）（ＯＶ３７４）（ＯＶ３７５）、−ＯＳｉ（Ｖ３７６）（Ｖ３７７）（Ｖ３７８）、−ＯＳ（Ｏ₂）−Ｖ３７９、−ＮＨＣ（Ｏ）−Ｖ３８０、−ＮＶ３８１Ｃ（Ｏ）−Ｖ３８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ３８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ３８４、−ＮＨ−Ｃ（Ｏ）−ＮＶ３８５Ｖ３８６、−ＮＶ３８７−Ｃ（Ｏ）−Ｏ−Ｖ３８８、−ＮＶ３８９−Ｃ（Ｏ）−ＮＨ−Ｖ３９０、−ＮＶ３９１−Ｃ（Ｏ）−ＮＶ３９２Ｖ３９３、−ＮＨＳ（Ｏ₂）−Ｖ３９４、−ＮＶ３９５Ｓ（Ｏ₂）−Ｖ３９６、−Ｓ−Ｖ３９７、−Ｓ（Ｏ）−Ｖ３９８、−Ｓ（Ｏ₂）−Ｖ３９９、−Ｓ（Ｏ₂）ＮＨ−Ｖ４００、−Ｓ（Ｏ₂）ＮＶ４０１Ｖ４０２、−Ｓ（Ｏ₂）Ｏ−Ｖ４０３、−Ｐ（Ｏ）（ＯＶ４０４）（ＯＶ４０５）、−Ｓｉ（Ｖ４０６）（Ｖ４０７）（Ｖ４０８）"；
その際、Ｖ３５７、Ｖ３５８、Ｖ３５９、Ｖ３６０、Ｖ３６１、Ｖ３６２、Ｖ３６３、Ｖ３６４、Ｖ３６５、Ｖ３６６、Ｖ３６７、Ｖ３６８、Ｖ３６９、Ｖ３７０、Ｖ３７１、Ｖ３７２、Ｖ３７３、Ｖ３７４、Ｖ３７５、Ｖ３７６、Ｖ３７７、Ｖ３７８、Ｖ３７９、Ｖ３８０、Ｖ３８１、Ｖ３８２、Ｖ３８３、Ｖ３８４、Ｖ３８５、Ｖ３８６、Ｖ３８７、Ｖ３８８、Ｖ３８９、Ｖ３９０、Ｖ３９１、Ｖ３９２、Ｖ３９３、Ｖ３９４、Ｖ３９５、Ｖ３９６、Ｖ３９７、Ｖ３９８、Ｖ３９９、Ｖ４００、Ｖ４０１、Ｖ４０２、Ｖ４０３、Ｖ４０４、Ｖ４０５、Ｖ４０６、Ｖ４０７、Ｖ４０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ３６３、Ｖ３６４及び／又はＶ３７２、Ｖ３７３及び／又はＶ３８５、Ｖ３８６及び／又はＶ３９２、Ｖ３９３及び／又はＶ４０１、Ｖ４０２は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）及び／又は置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ４０９、−ＮＶ４１０Ｖ４１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ４１２、−Ｃ（Ｏ）Ｏ−Ｖ４１３、−Ｃ（Ｏ）ＮＨ−Ｖ４１４、−Ｃ（Ｏ）ＮＶ４１５Ｖ４１６、−Ｏ−Ｖ４１７、−Ｏ（−Ｖ４１８−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−Ｏ（−Ｖ４１９−Ｏ）_x−Ｖ４２０（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ４２１、−ＯＣ（Ｏ）−Ｏ−Ｖ４２２、−ＯＣ（Ｏ）−ＮＨＶ４２３、−Ｏ−Ｃ（Ｏ）−ＮＶ４２４Ｖ４２５、−ＯＰ（Ｏ）（ＯＶ４２６）（ＯＶ４２７）、−ＯＳｉ（Ｖ４２８）（Ｖ４２９）（Ｖ４３０）、−ＯＳ（Ｏ₂）−Ｖ４３１、−ＮＨＣ（Ｏ）−Ｖ４３２、−ＮＶ４３３Ｃ（Ｏ）−Ｖ４３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ４３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ４３６、−ＮＨ−Ｃ（Ｏ）−ＮＶ４３７Ｖ４３８、−ＮＶ４３９−Ｃ（Ｏ）−Ｏ−Ｖ４４０、−ＮＶ４４１−Ｃ（Ｏ）−ＮＨ−Ｖ４４２、−ＮＶ４４３−Ｃ（Ｏ）−ＮＶ４４４Ｖ４４５、−ＮＨＳ（Ｏ₂）−Ｖ４４６、−ＮＶ４４７Ｓ（Ｏ₂）−Ｖ４４８、−Ｓ−Ｖ４４９、−Ｓ（Ｏ）−Ｖ４５０、−Ｓ（Ｏ₂）−Ｖ４５１、−Ｓ（Ｏ₂）ＮＨ−Ｖ４５２、−Ｓ（Ｏ₂）ＮＶ４５３Ｖ４５４、−Ｓ（Ｏ₂）Ｏ−Ｖ４５５、−Ｐ（Ｏ）（ＯＶ４５６ａ）（ＯＶ４５６ｂ）、−Ｓｉ（Ｖ４５６ｃ）（Ｖ４５６ｄ）（Ｖ４５６ｅ）"；
その際、Ｖ４０９、Ｖ４１０、Ｖ４１１、Ｖ４１２、Ｖ４１３、Ｖ４１４、Ｖ４１５、Ｖ４１６、Ｖ４１７、Ｖ４１８、Ｖ４１９、Ｖ４２０、Ｖ４２１、Ｖ４２２、Ｖ４２３、Ｖ４２４、Ｖ４２５、Ｖ４２６、Ｖ４２７、Ｖ４２８、Ｖ４２９、Ｖ４３０、Ｖ４３１、Ｖ４３２、Ｖ４３３、Ｖ４３４、Ｖ４３５、Ｖ４３６、Ｖ４３７、Ｖ４３８、Ｖ４３９、Ｖ４４０、Ｖ４４１、Ｖ４４２、Ｖ４４３、Ｖ４４４、Ｖ４４５、Ｖ４４６、Ｖ４４７、Ｖ４４８、Ｖ４４９、Ｖ４５０、Ｖ４５１、Ｖ４５２、Ｖ４５３、Ｖ４５４、Ｖ４５５、Ｖ４５６ａ、Ｖ４５６ｂ、Ｖ４５６ｃ、Ｖ４５６ｄ、Ｖ４５６ｅは、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ４１５、Ｖ４１６及び／又はＶ４２４、Ｖ４２５及び／又はＶ４３７、Ｖ４３８及び／又はＶ４４４、Ｖ４４５及び／又はＶ４５３、Ｖ４５４は、一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ３、Ｚ４の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ３、Ｚ４のどちらも、以下のものからなる群から選択されない：
（ｅ）水素；
（ｆ）ハロゲン、Ｆ、Ｃｌ、Ｂｒ、Ｉ；
（ｇ）非置換もしくは置換されたアルキルもしくはＣ₉〜Ｃ₃₀−アルキル、
その際、場合により、前記のアルキル基もしくはＣ₉〜Ｃ₃₀−アルキル基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ４５７、−ＮＶ４５８Ｖ４５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ４６０、−Ｃ（Ｏ）Ｏ−Ｖ４６１、−Ｃ（Ｏ）ＮＨ−Ｖ４６２、−Ｃ（Ｏ）ＮＶ４６３Ｖ４６４、−Ｏ−Ｖ４６５、−Ｏ（−Ｖ４６６−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｖ４６７−Ｏ）_y−Ｖ４６８（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ４６９、−ＯＣ（Ｏ）−Ｏ−Ｖ４７０、−ＯＣ（Ｏ）−ＮＨＶ４７１、−Ｏ−Ｃ（Ｏ）−ＮＶ４７２Ｖ４７３、−ＯＰ（Ｏ）（ＯＶ４７４）（ＯＶ４７５）、−ＯＳｉ（Ｖ４７６）（Ｖ４７７）（Ｖ４７８）、−ＯＳ（Ｏ₂）−Ｖ４７９、−ＮＨＣ（Ｏ）−Ｖ４８０、−ＮＶ４８１Ｃ（Ｏ）−Ｖ４８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ４８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ４８４、−ＮＨ−Ｃ（Ｏ）−ＮＶ４８５Ｖ４８６、−ＮＶ４８７−Ｃ（Ｏ）−Ｏ−Ｖ４８８、−ＮＶ４８９−Ｃ（Ｏ）−ＮＨ−Ｖ４９０、−ＮＶ４９１−Ｃ（Ｏ）−ＮＶ４９２Ｖ４９３、−ＮＨＳ（Ｏ₂）−Ｖ４９４、−ＮＶ４９５Ｓ（Ｏ₂）−Ｖ４９６、−Ｓ−Ｖ４９７、−Ｓ（Ｏ）−Ｖ４９８、−Ｓ（Ｏ₂）−Ｖ４９９、−Ｓ（Ｏ₂）ＮＨ−Ｖ５００、−Ｓ（Ｏ₂）ＮＶ５０１Ｖ５０２、−Ｓ（Ｏ₂）Ｏ−Ｖ５０３、−Ｐ（Ｏ）（ＯＶ５０４）（ＯＶ５０５）、−Ｓｉ（Ｖ５０６）（Ｖ５０７）（Ｖ５０８）"；
その際、Ｖ４５７、Ｖ４５８、Ｖ４５９、Ｖ４６０、Ｖ４６１、Ｖ４６２、Ｖ４６３、Ｖ４６４、Ｖ４６５、Ｖ４６６、Ｖ４６７、Ｖ４６８、Ｖ４６９、Ｖ４７０、Ｖ４７１、Ｖ４７２、Ｖ４７３、Ｖ４７４、Ｖ４７５、Ｖ４７６、Ｖ４７７、Ｖ４７８、Ｖ４７９、Ｖ４８０、Ｖ４８１、Ｖ４８２、Ｖ４８３、Ｖ４８４、Ｖ４８５、Ｖ４８６、Ｖ４８７、Ｖ４８８、Ｖ４８９、Ｖ４９０、Ｖ４９１、Ｖ４９２、Ｖ４９３、Ｖ４９４、Ｖ４９５、Ｖ４９６、Ｖ４９７、Ｖ４９８、Ｖ４９９、Ｖ５００、Ｖ５０１、Ｖ５０２、Ｖ５０３、Ｖ５０４、Ｖ５０５、Ｖ５０６、Ｖ５０７、Ｖ５０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ４６３、Ｖ４６４及び／又はＶ４７２、Ｖ４７３及び／又はＶ４８５、Ｖ４８６及び／又はＶ４９２、Ｖ４９３及び／又はＶ５０１、Ｖ５０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ５０９、−ＮＶ５１０Ｖ５１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ５１２、−Ｃ（Ｏ）Ｏ−Ｖ５１３、−Ｃ（Ｏ）ＮＨ−Ｖ５１４、−Ｃ（Ｏ）ＮＶ５１５Ｖ５１６、−Ｏ−Ｖ５１７、−Ｏ（−Ｖ５１８−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｖ５１９−Ｏ）_z−Ｖ５２０（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ５２１、−ＯＣ（Ｏ）−Ｏ−Ｖ５２２、−ＯＣ（Ｏ）−ＮＨＶ５２３、−Ｏ−Ｃ（Ｏ）−ＮＶ５２４Ｖ５２５、−ＯＰ（Ｏ）（ＯＶ５２６）（ＯＶ５２７）、−ＯＳｉ（Ｖ５２８）（Ｖ５２９）（Ｖ５３０）、−ＯＳ（Ｏ₂）−Ｖ５３１、−ＮＨＣ（Ｏ）−Ｖ５３２、−ＮＶ５３３Ｃ（Ｏ）−Ｖ５３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ５３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ５３６、−ＮＨ−Ｃ（Ｏ）−ＮＶ５３７Ｖ５３８、−ＮＶ５３９−Ｃ（Ｏ）−Ｏ−Ｖ５４０、−ＮＶ５４１−Ｃ（Ｏ）−ＮＨ−Ｖ５４２、−ＮＶ５４３−Ｃ（Ｏ）−ＮＶ５４４Ｖ５４５、−ＮＨＳ（Ｏ₂）−Ｖ５４６、−ＮＶ５４７Ｓ（Ｏ₂）−Ｖ５４８、−Ｓ−Ｖ５４９、−Ｓ（Ｏ）−Ｖ５５０、−Ｓ（Ｏ₂）−Ｖ５５１、−Ｓ（Ｏ₂）ＮＨ−Ｖ５５２、−Ｓ（Ｏ₂）ＮＶ５５３Ｖ５５４、−Ｓ（Ｏ₂）Ｏ−Ｖ５５５、−Ｐ（Ｏ）（ＯＶ５５６）（ＯＶ５５７）、−Ｓｉ（Ｖ５５８）（Ｖ５５９）（Ｖ５６０）"；
その際、Ｖ５０９、Ｖ５１０、Ｖ５１１、Ｖ５１２、Ｖ５１３、Ｖ５１４、Ｖ５１５、Ｖ５１６、Ｖ５１７、Ｖ５１８、Ｖ５１９、Ｖ５２０、Ｖ５２１、Ｖ５２２、Ｖ５２３、Ｖ５２４、Ｖ５２５、Ｖ５２６、Ｖ５２７、Ｖ５２８、Ｖ５２９、Ｖ５３０、Ｖ５３１、Ｖ５３２、Ｖ５３３、Ｖ５３４、Ｖ５３５、Ｖ５３６、Ｖ５３７、Ｖ５３８、Ｖ５３９、Ｖ５４０、Ｖ５４１、Ｖ５４２、Ｖ５４３、Ｖ５４４、Ｖ５４５、Ｖ５４６、Ｖ５４７、Ｖ５４８、Ｖ５４９、Ｖ５５０、Ｖ５５１、Ｖ５５２、Ｖ５５３、Ｖ５５４、Ｖ５５５、Ｖ５５６、Ｖ５５７、Ｖ５５８、Ｖ５５９、Ｖ５６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ５１５、Ｖ５１６及び／又はＶ５２４、Ｖ５２５及び／又はＶ５３７、Ｖ５３８及び／又はＶ５４４、Ｖ５４５及び／又はＶ５５３、Ｖ５５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ５６１、−ＮＶ５６２Ｖ５６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ５６４、−Ｃ（Ｏ）Ｏ−Ｖ５６５、−Ｃ（Ｏ）ＮＨ−Ｖ５６６、−Ｃ（Ｏ）ＮＶ５６７Ｖ５６８、−Ｏ−Ｖ５６９、−Ｏ（−Ｖ５７０−Ｏ）_a−Ｈ（ａ＝１、２、３、４、５）、−Ｏ（−Ｖ５７１−Ｏ）_a−Ｖ５７２（ａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ５７３、−ＯＣ（Ｏ）−Ｏ−Ｖ５７４、−ＯＣ（Ｏ）−ＮＨＶ５７５、−Ｏ−Ｃ（Ｏ）−ＮＶ５７６Ｖ５７７、−ＯＰ（Ｏ）（ＯＶ５７８）（ＯＶ５７９）、−ＯＳｉ（Ｖ５８０）（Ｖ５８１）（Ｖ５８２）、−ＯＳ（Ｏ₂）−Ｖ５８３、−ＮＨＣ（Ｏ）−Ｖ５８４、−ＮＶ５８５Ｃ（Ｏ）−Ｖ５８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ５８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ５８８、−ＮＨ−Ｃ（Ｏ）−ＮＶ５８９Ｖ５９０、−ＮＶ５９１−Ｃ（Ｏ）−Ｏ−Ｖ５９２、−ＮＶ５９３−Ｃ（Ｏ）−ＮＨ−Ｖ５９４、−ＮＶ５９５−Ｃ（Ｏ）−ＮＶ５９６Ｖ５９７、−ＮＨＳ（Ｏ₂）−Ｖ５９８、−ＮＶ５９９Ｓ（Ｏ₂）−Ｖ６００、−Ｓ−Ｖ６０１、−Ｓ（Ｏ）−Ｖ６０２、−Ｓ（Ｏ₂）−Ｖ６０３、−Ｓ（Ｏ₂）ＮＨ−Ｖ６０４、−Ｓ（Ｏ₂）ＮＶ６０５Ｖ６０６、−Ｓ（Ｏ₂）Ｏ−Ｖ６０７、−Ｐ（Ｏ）（ＯＶ６０８）（ＯＶ６０９）、−Ｓｉ（Ｖ６１０）（Ｖ６１１）（Ｖ６１２）"；
その際、Ｖ５６１、Ｖ５６２、Ｖ５６３、Ｖ５６４、Ｖ５６５、Ｖ５６６、Ｖ５６７、Ｖ５６８、Ｖ５６９、Ｖ５７０、Ｖ５７１、Ｖ５７２、Ｖ５７３、Ｖ５７４、Ｖ５７５、Ｖ５７６、Ｖ５７７、Ｖ５７８、Ｖ５７９、Ｖ５８０、Ｖ５８１、Ｖ５８２、Ｖ５８３、Ｖ５８４、Ｖ５８５、Ｖ５８６、Ｖ５８７、Ｖ５８８、Ｖ５８９、Ｖ５９０、Ｖ５９１、Ｖ５９２、Ｖ５９３、Ｖ５９４、Ｖ５９５、Ｖ５９６、Ｖ５９７、Ｖ５９８、Ｖ５９９、Ｖ６００、Ｖ６０１、Ｖ６０２、Ｖ６０３、Ｖ６０４、Ｖ６０５、Ｖ６０６、Ｖ６０７、Ｖ６０８、Ｖ６０９、Ｖ６１０、Ｖ６１１、Ｖ６１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ５６７、Ｖ５６８及び／又はＶ５７６、Ｖ５７７及び／又はＶ５８９、Ｖ５９０及び／又はＶ５９６、Ｖ５９７及び／又はＶ６０５、Ｖ６０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｈ）非置換もしくは置換されたアリール、
その際、場合により、前記のアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ６１３、−ＮＶ６１４Ｖ６１５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ６１６、−Ｃ（Ｏ）Ｏ−Ｖ６１７、−Ｃ（Ｏ）ＮＨ−Ｖ６１８、−Ｃ（Ｏ）ＮＶ６１９Ｖ６２０、−Ｏ−Ｖ６２１、−Ｏ（−Ｖ６２２−Ｏ）_b−Ｈ（ｂ＝１、２、３、４、５）、−Ｏ（−Ｖ６２３−Ｏ）_b−Ｖ６２４（ｂ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ６２５、−ＯＣ（Ｏ）−Ｏ−Ｖ６２６、−ＯＣ（Ｏ）−ＮＨＶ６２７、−Ｏ−Ｃ（Ｏ）−ＮＶ６２８Ｖ６２９、−ＯＰ（Ｏ）（ＯＶ６３０）（ＯＶ６３１）、−ＯＳｉ（Ｖ６３２）（Ｖ６３３）（Ｖ６３４）、−ＯＳ（Ｏ₂）−Ｖ６３５、−ＮＨＣ（Ｏ）−Ｖ６３６、−ＮＶ６３７Ｃ（Ｏ）−Ｖ６３８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ６３９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ６４０、−ＮＨ−Ｃ（Ｏ）−ＮＶ６４１Ｖ６４２、−ＮＶ６４３−Ｃ（Ｏ）−Ｏ−Ｖ６４４、−ＮＶ６４５−Ｃ（Ｏ）−ＮＨ−Ｖ６４６、−ＮＶ６４７−Ｃ（Ｏ）−ＮＶ６４８Ｖ６４９、−ＮＨＳ（Ｏ₂）−Ｖ６５０、−ＮＶ６５１Ｓ（Ｏ₂）−Ｖ６５２、−Ｓ−Ｖ６５３、−Ｓ（Ｏ）−Ｖ６５４、−Ｓ（Ｏ₂）−Ｖ６５５、−Ｓ（Ｏ₂）ＮＨ−Ｖ６５６、−Ｓ（Ｏ₂）ＮＶ６５７Ｖ６５８、−Ｓ（Ｏ₂）Ｏ−Ｖ６５９、−Ｐ（Ｏ）（ＯＶ６６０）（ＯＶ６６１）、−Ｓｉ（Ｖ６６２）（Ｖ６６３）（Ｖ６６４）"；
その際、Ｖ６１３、Ｖ６１４、Ｖ６１５、Ｖ６１６、Ｖ６１７、Ｖ６１８、Ｖ６１９、Ｖ６２０、Ｖ６２１、Ｖ６２２、Ｖ６２３、Ｖ６２４、Ｖ６２５、Ｖ６２６、Ｖ６２７、Ｖ６２８、Ｖ６２９、Ｖ６３０、Ｖ６３１、Ｖ６３２、Ｖ６３３、Ｖ６３４、Ｖ６３５、Ｖ６３６、Ｖ６３７、Ｖ６３８、Ｖ６３９、Ｖ６４０、Ｖ６４１、Ｖ６４２、Ｖ６４３、Ｖ６４４、Ｖ６４５、Ｖ６４６、Ｖ６４７、Ｖ６４８、Ｖ６４９、Ｖ６５０、Ｖ６５１、Ｖ６５２、Ｖ６５３、Ｖ６５４、Ｖ６５５、Ｖ６５６、Ｖ６５７、Ｖ６５８、Ｖ６５９、Ｖ６６０、Ｖ６６１、Ｖ６６２、Ｖ６６３、Ｖ６６４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ６１９、Ｖ６２０及び／又はＶ６２８、Ｖ６２９及び／又はＶ６４１、Ｖ６４２及び／又はＶ６４８、Ｖ６４９及び／又はＶ６５７、Ｖ６５８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ６６５、−ＮＶ６６６Ｖ６６７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ６６８、−Ｃ（Ｏ）Ｏ−Ｖ６６９、−Ｃ（Ｏ）ＮＨ−Ｖ６７０、−Ｃ（Ｏ）ＮＶ６７１Ｖ６７２、−Ｏ−Ｖ６７３、−Ｏ（−Ｖ６７４−Ｏ）_c−Ｈ（ｃ＝１、２、３、４、５）、−Ｏ（−Ｖ６７５−Ｏ）_c−Ｖ６７６（ｃ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ６７７、−ＯＣ（Ｏ）−Ｏ−Ｖ６７８、−ＯＣ（Ｏ）−ＮＨＶ６７９、−Ｏ−Ｃ（Ｏ）−ＮＶ６８０Ｖ６８１、−ＯＰ（Ｏ）（ＯＶ６８２）（ＯＶ６８３）、−ＯＳｉ（Ｖ６８４）（Ｖ６８５）（Ｖ６８６）、−ＯＳ（Ｏ₂）−Ｖ６８７、−ＮＨＣ（Ｏ）−Ｖ６８８、−ＮＶ６８９Ｃ（Ｏ）−Ｖ６９０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ６９１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ６９２、−ＮＨ−Ｃ（Ｏ）−ＮＶ６９３Ｖ６９４、−ＮＶ６９５−Ｃ（Ｏ）−Ｏ−Ｖ６９６、−ＮＶ６９７−Ｃ（Ｏ）−ＮＨ−Ｖ６９８、−ＮＶ６９９−Ｃ（Ｏ）−ＮＶ７００Ｖ７０１、−ＮＨＳ（Ｏ₂）−Ｖ７０２、−ＮＶ７０３Ｓ（Ｏ₂）−Ｖ７０４、−Ｓ−Ｖ７０５、−Ｓ（Ｏ）−Ｖ７０６、−Ｓ（Ｏ₂）−Ｖ７０７、−Ｓ（Ｏ₂）ＮＨ−Ｖ７０８、−Ｓ（Ｏ₂）ＮＶ７０９Ｖ７１０、−Ｓ（Ｏ₂）Ｏ−Ｖ７１１、−Ｐ（Ｏ）（ＯＶ７１２）（ＯＶ７１３）、−Ｓｉ（Ｖ７１４）（Ｖ７１５）（Ｖ７１６）"；
その際、Ｖ６６５、Ｖ６６６、Ｖ６６７、Ｖ６６８、Ｖ６６９、Ｖ６７０、Ｖ６７１、Ｖ６７２、Ｖ６７３、Ｖ６７４、Ｖ６７５、Ｖ６７６、Ｖ６７７、Ｖ６７８、Ｖ６７９、Ｖ６８０、Ｖ６８１、Ｖ６８２、Ｖ６８３、Ｖ６８４、Ｖ６８５、Ｖ６８６、Ｖ６８７、Ｖ６８８、Ｖ６８９、Ｖ６９０、Ｖ６９１、Ｖ６９２、Ｖ６９３、Ｖ６９４、Ｖ６９５、Ｖ６９６、Ｖ６９７、Ｖ６９８、Ｖ６９９、Ｖ７００、Ｖ７０１、Ｖ７０２、Ｖ７０３、Ｖ７０４、Ｖ７０５、Ｖ７０６、Ｖ７０７、Ｖ７０８、Ｖ７０９、Ｖ７１０、Ｖ７１１、Ｖ７１２、Ｖ７１３、Ｖ７１４、Ｖ７１５、Ｖ７１６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ６７１、Ｖ６７２及び／又はＶ６８０、Ｖ６８１及び／又はＶ６９３、Ｖ６９４及び／又はＶ７００、Ｖ７０１及び／又はＶ７０９、Ｖ７１０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ７１７、−ＮＶ７１８Ｖ７１９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ７２０、−Ｃ（Ｏ）Ｏ−Ｖ７２１、−Ｃ（Ｏ）ＮＨ−Ｖ７２２、−Ｃ（Ｏ）ＮＶ７２３Ｖ７２４、−Ｏ−Ｖ７２５、−Ｏ（−Ｖ７２６−Ｏ）_d−Ｈ（ｄ＝１、２、３、４、５）、−Ｏ（−Ｖ７２７−Ｏ）_d−Ｖ７２８（ｄ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ７２９、−ＯＣ（Ｏ）−Ｏ−Ｖ７３０、−ＯＣ（Ｏ）−ＮＨＶ７３１、−Ｏ−Ｃ（Ｏ）−ＮＶ７３２Ｖ７３３、−ＯＰ（Ｏ）（ＯＶ７３４）（ＯＶ７３５）、−ＯＳｉ（Ｖ７３６）（Ｖ７３７）（Ｖ７３８）、−ＯＳ（Ｏ₂）−Ｖ７３９、−ＮＨＣ（Ｏ）−Ｖ７４０、−ＮＶ７４１Ｃ（Ｏ）−Ｖ７４２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ７４３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ７４４、−ＮＨ−Ｃ（Ｏ）−ＮＶ７４５Ｖ７４６、−ＮＶ７４７−Ｃ（Ｏ）−Ｏ−Ｖ７４８、−ＮＶ７４９−Ｃ（Ｏ）−ＮＨ−Ｖ７５０、−ＮＶ７５１−Ｃ（Ｏ）−ＮＶ７５２Ｖ７５３、−ＮＨＳ（Ｏ₂）−Ｖ７５４、−ＮＶ７５５Ｓ（Ｏ₂）−Ｖ７５６、−Ｓ−Ｖ７５７、−Ｓ（Ｏ）−Ｖ７５８、−Ｓ（Ｏ₂）−Ｖ７５９、−Ｓ（Ｏ₂）ＮＨ−Ｖ７６０、−Ｓ（Ｏ₂）ＮＶ７６１Ｖ７６２、−Ｓ（Ｏ₂）Ｏ−Ｖ７６３、−Ｐ（Ｏ）（ＯＶ７６４）（ＯＶ７６５）、−Ｓｉ（Ｖ７６６）（Ｖ７６７）（Ｖ７６８）"；
その際、Ｖ７１７、Ｖ７１８、Ｖ７１９、Ｖ７２０、Ｖ７２１、Ｖ７２２、Ｖ７２３、Ｖ７２４、Ｖ７２５、Ｖ７２６、Ｖ７２７、Ｖ７２８、Ｖ７２９、Ｖ７３０、Ｖ７３１、Ｖ７３２、Ｖ７３３、Ｖ７３４、Ｖ７３５、Ｖ７３６、Ｖ７３７、Ｖ７３８、Ｖ７３９、Ｖ７４０、Ｖ７４１、Ｖ７４２、Ｖ７４３、Ｖ７４４、Ｖ７４５、Ｖ７４６、Ｖ７４７、Ｖ７４８、Ｖ７４９、Ｖ７５０、Ｖ７５１、Ｖ７５２、Ｖ７５３、Ｖ７５４、Ｖ７５５、Ｖ７５６、Ｖ７５７、Ｖ７５８、Ｖ７５９、Ｖ７６０、Ｖ７６１、Ｖ７６２、Ｖ７６３、Ｖ７６４、Ｖ７６５、Ｖ７６６、Ｖ７６７、Ｖ７６８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ７２３、Ｖ７２４及び／又はＶ７３２、Ｖ７３３及び／又はＶ７４５、Ｖ７４６及び／又はＶ７５２、Ｖ７５３及び／又はＶ７６１、Ｖ７６２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｊ）非置換もしくは置換されたヘテロアリール、
その際、場合により、前記のヘテロアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ７６９、−ＮＶ７７０Ｖ７７１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ７７２、−Ｃ（Ｏ）Ｏ−Ｖ７７３、−Ｃ（Ｏ）ＮＨ−Ｖ７７４、−Ｃ（Ｏ）ＮＶ７７５Ｖ７７６、−Ｏ−Ｖ７７７、−Ｏ（−Ｖ７７８−Ｏ）_e−Ｈ（ｅ＝１、２、３、４、５）、−Ｏ（−Ｖ７７９−Ｏ）_e−Ｖ７８０（ｅ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ７８１、−ＯＣ（Ｏ）−Ｏ−Ｖ７８２、−ＯＣ（Ｏ）−ＮＨＶ７８３、−Ｏ−Ｃ（Ｏ）−ＮＶ７８４Ｖ７８５、−ＯＰ（Ｏ）（ＯＶ７８６）（ＯＶ７８７）、−ＯＳｉ（Ｖ７８８）（Ｖ７８９）（Ｖ７９０）、−ＯＳ（Ｏ₂）−Ｖ７９１、−ＮＨＣ（Ｏ）−Ｖ７９２、−ＮＶ７９３Ｃ（Ｏ）−Ｖ７９４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ７９５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ７９６、−ＮＨ−Ｃ（Ｏ）−ＮＶ７９７Ｖ７９８、−ＮＶ７９９−Ｃ（Ｏ）−Ｏ−Ｖ８００、−ＮＶ８０１−Ｃ（Ｏ）−ＮＨ−Ｖ８０２、−ＮＶ８０３−Ｃ（Ｏ）−ＮＶ８０４Ｖ８０５、−ＮＨＳ（Ｏ₂）−Ｖ８０６、−ＮＶ８０７Ｓ（Ｏ₂）−Ｖ８０８、−Ｓ−Ｖ８０９、−Ｓ（Ｏ）−Ｖ８１０、−Ｓ（Ｏ₂）−Ｖ８１１、−Ｓ（Ｏ₂）ＮＨ−Ｖ８１２、−Ｓ（Ｏ₂）ＮＶ８１３Ｖ８１４、−Ｓ（Ｏ₂）Ｏ−Ｖ８１５、−Ｐ（Ｏ）（ＯＶ８１６）（ＯＶ８１７）、−Ｓｉ（Ｖ８１８）（Ｖ８１９）（Ｖ８２０）"；
その際、Ｖ７６９、Ｖ７７０、Ｖ７７１、Ｖ７７２、Ｖ７７３、Ｖ７７４、Ｖ７７５、Ｖ７７６、Ｖ７７７、Ｖ７７８、Ｖ７７９、Ｖ７８０、Ｖ７８１、Ｖ７８２、Ｖ７８３、Ｖ７８４、Ｖ７８５、Ｖ７８６、Ｖ７８７、Ｖ７８８、Ｖ７８９、Ｖ７９０、Ｖ７９１、Ｖ７９２、Ｖ７９３、Ｖ７９４、Ｖ７９５、Ｖ７９６、Ｖ７９７、Ｖ７９８、Ｖ７９９、Ｖ８００、Ｖ８０１、Ｖ８０２、Ｖ８０３、Ｖ８０４、Ｖ８０５、Ｖ８０６、Ｖ８０７、Ｖ８０８、Ｖ８０９、Ｖ８１０、Ｖ８１１、Ｖ８１２、Ｖ８１３、Ｖ８１４、Ｖ８１５、Ｖ８１６、Ｖ８１７、Ｖ８１８、Ｖ８１９、Ｖ８２０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ７７５、Ｖ７７６及び／又はＶ７８４、Ｖ７８５及び／又はＶ７９７、Ｖ７９８及び／又はＶ８０４、Ｖ８０５及び／又はＶ８１３、Ｖ８１４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ８２１、−ＮＶ８２２Ｖ８２３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ８２４、−Ｃ（Ｏ）Ｏ−Ｖ８２５、−Ｃ（Ｏ）ＮＨ−Ｖ８２６、−Ｃ（Ｏ）ＮＶ８２７Ｖ８２８、−Ｏ−Ｖ８２９、−Ｏ（−Ｖ８３０−Ｏ）_f−Ｈ（ｆ＝１、２、３、４、５）、−Ｏ（−Ｖ８３１−Ｏ）_f−Ｖ８３２（ｆ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ８３３、−ＯＣ（Ｏ）−Ｏ−Ｖ８３４、−ＯＣ（Ｏ）−ＮＨＶ８３５、−Ｏ−Ｃ（Ｏ）−ＮＶ８３６Ｖ８３７、−ＯＰ（Ｏ）（ＯＶ８３８）（ＯＶ８３９）、−ＯＳｉ（Ｖ８４０）（Ｖ８４１）（Ｖ８４２）、−ＯＳ（Ｏ₂）−Ｖ８４３、−ＮＨＣ（Ｏ）−Ｖ８４４、−ＮＶ８４５Ｃ（Ｏ）−Ｖ８４６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ８４７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ８４８、−ＮＨ−Ｃ（Ｏ）−ＮＶ８４９Ｖ８５０、−ＮＶ８５１−Ｃ（Ｏ）−Ｏ−Ｖ８５２、−ＮＶ８５３−Ｃ（Ｏ）−ＮＨ−Ｖ８５４、−ＮＶ８５５−Ｃ（Ｏ）−ＮＶ８５６Ｖ８５７、−ＮＨＳ（Ｏ₂）−Ｖ８５８、−ＮＶ８５９Ｓ（Ｏ₂）−Ｖ８６０、−Ｓ−Ｖ８６１、−Ｓ（Ｏ）−Ｖ８６２、−Ｓ（Ｏ₂）−Ｖ８６３、−Ｓ（Ｏ₂）ＮＨ−Ｖ８６４、−Ｓ（Ｏ₂）ＮＶ８６５Ｖ８６６、−Ｓ（Ｏ₂）Ｏ−Ｖ８６７、−Ｐ（Ｏ）（ＯＶ８６８）（ＯＶ８６９）、−Ｓｉ（Ｖ８７０）（Ｖ８７１）（Ｖ８７２）"；
その際、Ｖ８２１、Ｖ８２２、Ｖ８２３、Ｖ８２４、Ｖ８２５、Ｖ８２６、Ｖ８２７、Ｖ８２８、Ｖ８２９、Ｖ８３０、Ｖ８３１、Ｖ８３２、Ｖ８３３、Ｖ８３４、Ｖ８３５、Ｖ８３６、Ｖ８３７、Ｖ８３８、Ｖ８３９、Ｖ８４０、Ｖ８４１、Ｖ８４２、Ｖ８４３、Ｖ８４４、Ｖ８４５、Ｖ８４６、Ｖ８４７、Ｖ８４８、Ｖ８４９、Ｖ８５０、Ｖ８５１、Ｖ８５２、Ｖ８５３、Ｖ８５４、Ｖ８５５、Ｖ８５６、Ｖ８５７、Ｖ８５８、Ｖ８５９、Ｖ８６０、Ｖ８６１、Ｖ８６２、Ｖ８６３、Ｖ８６４、Ｖ８６５、Ｖ８６６、Ｖ８６７、Ｖ８６８、Ｖ８６９、Ｖ８７０、Ｖ８７１、Ｖ８７２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ８２７、Ｖ８２８及び／又はＶ８３６、Ｖ８３７及び／又はＶ８４９、Ｖ８５０及び／又はＶ８５６、Ｖ８５７及び／又はＶ８６５、Ｖ８６６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ８７３、−ＮＶ８７４Ｖ８７５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ８７６、−Ｃ（Ｏ）Ｏ−Ｖ８７７、−Ｃ（Ｏ）ＮＨ−Ｖ８７８、−Ｃ（Ｏ）ＮＶ８７９Ｖ８８０、−Ｏ−Ｖ８８１、−Ｏ（−Ｖ８８２−Ｏ）_g−Ｈ（ｇ＝１、２、３、４、５）、−Ｏ（−Ｖ８８３−Ｏ）_g−Ｖ８８４（ｇ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ８８５、−ＯＣ（Ｏ）−Ｏ−Ｖ８８６、−ＯＣ（Ｏ）−ＮＨＶ８８７、−Ｏ−Ｃ（Ｏ）−ＮＶ８８８Ｖ８８９、−ＯＰ（Ｏ）（ＯＶ８９０）（ＯＶ８９１）、−ＯＳｉ（Ｖ８９２）（Ｖ８９３）（Ｖ８９４）、−ＯＳ（Ｏ₂）−Ｖ８９５、−ＮＨＣ（Ｏ）−Ｖ８９６、−ＮＶ８９７Ｃ（Ｏ）−Ｖ８９８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ８９９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ９００、−ＮＨ−Ｃ（Ｏ）−ＮＶ９０１Ｖ９０２、−ＮＶ９０３−Ｃ（Ｏ）−Ｏ−Ｖ９０４、−ＮＶ９０５−Ｃ（Ｏ）−ＮＨ−Ｖ９０６、−ＮＶ９０７−Ｃ（Ｏ）−ＮＶ９０８Ｖ９０９、−ＮＨＳ（Ｏ₂）−Ｖ９１０、−ＮＶ９１１Ｓ（Ｏ₂）−Ｖ９１２、−Ｓ−Ｖ９１３、−Ｓ（Ｏ）−Ｖ９１４、−Ｓ（Ｏ₂）−Ｖ９１５、−Ｓ（Ｏ₂）ＮＨ−Ｖ９１６、−Ｓ（Ｏ₂）ＮＶ９１７Ｖ９１８、−Ｓ（Ｏ₂）Ｏ−Ｖ９１９、−Ｐ（Ｏ）（ＯＶ９２０）（ＯＶ９２１）、−Ｓｉ（Ｖ９２２）（Ｖ９２３）（Ｖ９２４）"；
その際、Ｖ８７３、Ｖ８７４、Ｖ８７５、Ｖ８７６、Ｖ８７７、Ｖ８７８、Ｖ８７９、Ｖ８８０、Ｖ８８１、Ｖ８８２、Ｖ８８３、Ｖ８８４、Ｖ８８５、Ｖ８８６、Ｖ８８７、Ｖ８８８、Ｖ８８９、Ｖ８９０、Ｖ８９１、Ｖ８９２、Ｖ８９３、Ｖ８９４、Ｖ８９５、Ｖ８９６、Ｖ８９７、Ｖ８９８、Ｖ８９９、Ｖ９００、Ｖ９０１、Ｖ９０２、Ｖ９０３、Ｖ９０４、Ｖ９０５、Ｖ９０６、Ｖ９０７、Ｖ９０８、Ｖ９０９、Ｖ９１０、Ｖ９１１、Ｖ９１２、Ｖ９１３、Ｖ９１４、Ｖ９１５、Ｖ９１６、Ｖ９１７、Ｖ９１８、Ｖ９１９、Ｖ９２０、Ｖ９２１、Ｖ９２２、Ｖ９２３、Ｖ９２４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ８７９、Ｖ８８０及び／又はＶ８８８、Ｖ８８９及び／又はＶ９０１、Ｖ９０２及び／又はＶ９０８、Ｖ９０９及び／又はＶ９１７、Ｖ９１８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｋ）ＯＺ６、
その際、Ｚ６は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ９２５、−ＮＶ９２６Ｖ９２７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ９２８、−Ｃ（Ｏ）Ｏ−Ｖ９２９、−Ｃ（Ｏ）ＮＨ−Ｖ９３０、−Ｃ（Ｏ）ＮＶ９３１Ｖ９３２、−Ｏ−Ｖ９３３、−Ｏ（−Ｖ９３４−Ｏ）_h−Ｈ（ｈ＝１、２、３、４、５）、−Ｏ（−Ｖ９３５−Ｏ）_h−Ｖ９３６（ｈ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ９３７、−ＯＣ（Ｏ）−Ｏ−Ｖ９３８、−ＯＣ（Ｏ）−ＮＨＶ９３９、−Ｏ−Ｃ（Ｏ）−ＮＶ９４０Ｖ９４１、−ＯＰ（Ｏ）（ＯＶ９４２）（ＯＶ９４３）、−ＯＳｉ（Ｖ９４４）（Ｖ９４５）（Ｖ９４６）、−ＯＳ（Ｏ₂）−Ｖ９４７、−ＮＨＣ（Ｏ）−Ｖ９４８、−ＮＶ９４９Ｃ（Ｏ）−Ｖ９５０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ９５１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ９５２、−ＮＨ−Ｃ（Ｏ）−ＮＶ９５３Ｖ９５４、−ＮＶ９５５−Ｃ（Ｏ）−Ｏ−Ｖ９５６、−ＮＶ９５７−Ｃ（Ｏ）−ＮＨ−Ｖ９５８、−ＮＶ９５９−Ｃ（Ｏ）−ＮＶ９６０Ｖ９６１、−ＮＨＳ（Ｏ₂）−Ｖ９６２、−ＮＶ９６３Ｓ（Ｏ₂）−Ｖ９６４、−Ｓ−Ｖ９６５、−Ｓ（Ｏ）−Ｖ９６６、−Ｓ（Ｏ₂）−Ｖ９６７、−Ｓ（Ｏ₂）ＮＨ−Ｖ９６８、−Ｓ（Ｏ₂）ＮＶ９６９Ｖ９７０、−Ｓ（Ｏ₂）Ｏ−Ｖ９７１、−Ｐ（Ｏ）（ＯＶ９７２）（ＯＶ９７３）、−Ｓｉ（Ｖ９７４）（Ｖ９７５）（Ｖ９７６）"；
その際、Ｖ９２５、Ｖ９２６、Ｖ９２７、Ｖ９２８、Ｖ９２９、Ｖ９３０、Ｖ９３１、Ｖ９３２、Ｖ９３３、Ｖ９３４、Ｖ９３５、Ｖ９３６、Ｖ９３７、Ｖ９３８、Ｖ９３９、Ｖ９４０、Ｖ９４１、Ｖ９４２、Ｖ９４３、Ｖ９４４、Ｖ９４５、Ｖ９４６、Ｖ９４７、Ｖ９４８、Ｖ９４９、Ｖ９５０、Ｖ９５１、Ｖ９５２、Ｖ９５３、Ｖ９５４、Ｖ９５５、Ｖ９５６、Ｖ９５７、Ｖ９５８、Ｖ９５９、Ｖ９６０、Ｖ９６１、Ｖ９６２、Ｖ９６３、Ｖ９６４、Ｖ９６５、Ｖ９６６、Ｖ９６７、Ｖ９６８、Ｖ９６９、Ｖ９７０、Ｖ９７１、Ｖ９７２、Ｖ９７３、Ｖ９７４、Ｖ９７５、Ｖ９７６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ９３１、Ｖ９３２及び／又はＶ９４０、Ｖ９４１及び／又はＶ９５３、Ｖ９５４及び／又はＶ９６０、Ｖ９６１及び／又はＶ９６９、Ｖ９７０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ９７７、−ＮＶ９７８Ｖ９７９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ９８０、−Ｃ（Ｏ）Ｏ−Ｖ９８１、−Ｃ（Ｏ）ＮＨ−Ｖ９８２、−Ｃ（Ｏ）ＮＶ９８３Ｖ９８４、−Ｏ−Ｖ９８５、−Ｏ（−Ｖ９８６−Ｏ）_i−Ｈ（ｉ＝１、２、３、４、５）、−Ｏ（−Ｖ９８７−Ｏ）_i−Ｖ９８８（ｉ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ９８９、−ＯＣ（Ｏ）−Ｏ−Ｖ９９０、−ＯＣ（Ｏ）−ＮＨＶ９９１、−Ｏ−Ｃ（Ｏ）−ＮＶ９９２Ｖ９９３、−ＯＰ（Ｏ）（ＯＶ９９４）（ＯＶ９９５）、−ＯＳｉ（Ｖ９９６）（Ｖ９９７）（Ｖ９９８）、−ＯＳ（Ｏ₂）−Ｖ９９９、−ＮＨＣ（Ｏ）−Ｖ１０００、−ＮＶ１００１Ｃ（Ｏ）−Ｖ１００２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１００３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１００４、−ＮＨ−Ｃ（Ｏ）−ＮＶ１００５Ｖ１００６、−ＮＶ１００７−Ｃ（Ｏ）−Ｏ−Ｖ１００８、−ＮＶ１００９−Ｃ（Ｏ）−ＮＨ−Ｖ１０１０、−ＮＶ１０１１−Ｃ（Ｏ）−ＮＶ１０１２Ｖ１０１３、−ＮＨＳ（Ｏ₂）−Ｖ１０１４、−ＮＶ１０１５Ｓ（Ｏ₂）−Ｖ１０１６、−Ｓ−Ｖ１０１７、−Ｓ（Ｏ）−Ｖ１０１８、−Ｓ（Ｏ₂）−Ｖ１０１９、−Ｓ（Ｏ₂）ＮＨ−Ｖ１０２０、−Ｓ（Ｏ₂）ＮＶ１０２１Ｖ１０２２、−Ｓ（Ｏ₂）Ｏ−Ｖ１０２３、−Ｐ（Ｏ）（ＯＶ１０２４）（ＯＶ１０２５）、−Ｓｉ（Ｖ１０２６）（Ｖ１０２７）（Ｖ１０２８）"；
その際、Ｖ９７７、Ｖ９７８、Ｖ９７９、Ｖ９８０、Ｖ９８１、Ｖ９８２、Ｖ９８３、Ｖ９８４、Ｖ９８５、Ｖ９８６、Ｖ９８７、Ｖ９８８、Ｖ９８９、Ｖ９９０、Ｖ９９１、Ｖ９９２、Ｖ９９３、Ｖ９９４、Ｖ９９５、Ｖ９９６、Ｖ９９７、Ｖ９９８、Ｖ９９９、Ｖ１０００、Ｖ１００１、Ｖ１００２、Ｖ１００３、Ｖ１００４、Ｖ１００５、Ｖ１００６、Ｖ１００７、Ｖ１００８、Ｖ１００９、Ｖ１０１０、Ｖ１０１１、Ｖ１０１２、Ｖ１０１３、Ｖ１０１４、Ｖ１０１５、Ｖ１０１６、Ｖ１０１７、Ｖ１０１８、Ｖ１０１９、Ｖ１０２０、Ｖ１０２１、Ｖ１０２２、Ｖ１０２３、Ｖ１０２４、Ｖ１０２５、Ｖ１０２６、Ｖ１０２７、Ｖ１０２８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ９８３、Ｖ９８４及び／又はＶ９９２、Ｖ９９３及び／又はＶ１００５、Ｖ１００６及び／又はＶ１０１２、Ｖ１０１３及び／又はＶ１０２１、Ｖ１０２２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｌ）ＳＺ７、
その際、Ｚ７は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ１０２９、−ＮＶ１０３０Ｖ１０３１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ１０３２、−Ｃ（Ｏ）Ｏ−Ｖ１０３３、−Ｃ（Ｏ）ＮＨ−Ｖ１０３４、−Ｃ（Ｏ）ＮＶ１０３５Ｖ１０３６、−Ｏ−Ｖ１０３７、−Ｏ（−Ｖ１０３８−Ｏ）_j−Ｈ（ｊ＝１、２、３、４、５）、−Ｏ（−Ｖ１０３９−Ｏ）_j−Ｖ１０４０（ｊ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ１０４１、−ＯＣ（Ｏ）−Ｏ−Ｖ１０４２、−ＯＣ（Ｏ）−ＮＨＶ１０４３、−Ｏ−Ｃ（Ｏ）−ＮＶ１０４４Ｖ１０４５、−ＯＰ（Ｏ）（ＯＶ１０４６）（ＯＶ１０４７）、−ＯＳｉ（Ｖ１０４８）（Ｖ１０４９）（Ｖ１０５０）、−ＯＳ（Ｏ₂）−Ｖ１０５１、−ＮＨＣ（Ｏ）−Ｖ１０５２、−ＮＶ１０５３Ｃ（Ｏ）−Ｖ１０５４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１０５５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１０５６、−ＮＨ−Ｃ（Ｏ）−ＮＶ１０５７Ｖ１０５８、−ＮＶ１０５９−Ｃ（Ｏ）−Ｏ−Ｖ１０６０、−ＮＶ１０６１−Ｃ（Ｏ）−ＮＨ−Ｖ１０６２、−ＮＶ１０６３−Ｃ（Ｏ）−ＮＶ１０６４Ｖ１０６５、−ＮＨＳ（Ｏ₂）−Ｖ１０６６、−ＮＶ１０６７Ｓ（Ｏ₂）−Ｖ１０６８、−Ｓ−Ｖ１０６９、−Ｓ（Ｏ）−Ｖ１０７０、−Ｓ（Ｏ₂）−Ｖ１０７１、−Ｓ（Ｏ₂）ＮＨ−Ｖ１０７２、−Ｓ（Ｏ₂）ＮＶ１０７３Ｖ１０７４、−Ｓ（Ｏ₂）Ｏ−Ｖ１０７５、−Ｐ（Ｏ）（ＯＶ１０７６）（ＯＶ１０７７）、−Ｓｉ（Ｖ１０７８）（Ｖ１０７９）（Ｖ１０８０）"；
その際、Ｖ１０２９、Ｖ１０３０、Ｖ１０３１、Ｖ１０３２、Ｖ１０３３、Ｖ１０３４、Ｖ１０３５、Ｖ１０３６、Ｖ１０３７、Ｖ１０３８、Ｖ１０３９、Ｖ１０４０、Ｖ１０４１、Ｖ１０４２、Ｖ１０４３、Ｖ１０４４、Ｖ１０４５、Ｖ１０４６、Ｖ１０４７、Ｖ１０４８、Ｖ１０４９、Ｖ１０５０、Ｖ１０５１、Ｖ１０５２、Ｖ１０５３、Ｖ１０５４、Ｖ１０５５、Ｖ１０５６、Ｖ１０５７、Ｖ１０５８、Ｖ１０５９、Ｖ１０６０、Ｖ１０６１、Ｖ１０６２、Ｖ１０６３、Ｖ１０６４、Ｖ１０６５、Ｖ１０６６、Ｖ１０６７、Ｖ１０６８、Ｖ１０６９、Ｖ１０７０、Ｖ１０７１、Ｖ１０７２、Ｖ１０７３、Ｖ１０７４、Ｖ１０７５、Ｖ１０７６、Ｖ１０７７、Ｖ１０７８、Ｖ１０７９、Ｖ１０８０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ１０３５、Ｖ１０３６及び／又はＶ１０４４、Ｖ１０４５及び／又はＶ１０５７、Ｖ１０５８及び／又はＶ１０６４、Ｖ１０６５及び／又はＶ１０７３、Ｖ１０７４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ１０８１、−ＮＶ１０８２Ｖ１０８３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ１０８４、−Ｃ（Ｏ）Ｏ−Ｖ１０８５、−Ｃ（Ｏ）ＮＨ−Ｖ１０８６、−Ｃ（Ｏ）ＮＶ１０８７Ｖ１０８８、−Ｏ−Ｖ１０８９、−Ｏ（−Ｖ１０９０−Ｏ）_k−Ｈ（ｋ＝１、２、３、４、５）、−Ｏ（−Ｖ１０９１−Ｏ）_k−Ｖ１０９２（ｋ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ１０９３、−ＯＣ（Ｏ）−Ｏ−Ｖ１０９４、−ＯＣ（Ｏ）−ＮＨＶ１０９５、−Ｏ−Ｃ（Ｏ）−ＮＶ１０９６Ｖ１０９７、−ＯＰ（Ｏ）（ＯＶ１０９８）（ＯＶ１０９９）、−ＯＳｉ（Ｖ１１００）（Ｖ１１０１）（Ｖ１１０２）、−ＯＳ（Ｏ₂）−Ｖ１１０３、−ＮＨＣ（Ｏ）−Ｖ１１０４、−ＮＶ１１０５Ｃ（Ｏ）−Ｖ１１０６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１１０７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１１０８、−ＮＨ−Ｃ（Ｏ）−ＮＶ１１０９Ｖ１１１０、−ＮＶ１１１１−Ｃ（Ｏ）−Ｏ−Ｖ１１１２、−ＮＶ１１１３−Ｃ（Ｏ）−ＮＨ−Ｖ１１１４、−ＮＶ１１１５−Ｃ（Ｏ）−ＮＶ１１１６Ｖ１１１７、−ＮＨＳ（Ｏ₂）−Ｖ１１１８、−ＮＶ１１１９Ｓ（Ｏ₂）−Ｖ１１２０、−Ｓ−Ｖ１１２１、−Ｓ（Ｏ）−Ｖ１１２２、−Ｓ（Ｏ₂）−Ｖ１１２３、−Ｓ（Ｏ₂）ＮＨ−Ｖ１１２４、−Ｓ（Ｏ₂）ＮＶ１１２５Ｖ１１２６、−Ｓ（Ｏ₂）Ｏ−Ｖ１１２７、−Ｐ（Ｏ）（ＯＶ１１２８）（ＯＶ１１２９）、−Ｓｉ（Ｖ１１３０）（Ｖ１１３１）（Ｖ１１３２）"；
その際、Ｖ１０８１、Ｖ１０８２、Ｖ１０８３、Ｖ１０８４、Ｖ１０８５、Ｖ１０８６、Ｖ１０８７、Ｖ１０８８、Ｖ１０８９、Ｖ１０９０、Ｖ１０９１、Ｖ１０９２、Ｖ１０９３、Ｖ１０９４、Ｖ１０９５、Ｖ１０９６、Ｖ１０９７、Ｖ１０９８、Ｖ１０９９、Ｖ１１００、Ｖ１１０１、Ｖ１１０２、Ｖ１１０３、Ｖ１１０４、Ｖ１１０５、Ｖ１１０６、Ｖ１１０７、Ｖ１１０８、Ｖ１１０９、Ｖ１１１０、Ｖ１１１１、Ｖ１１１２、Ｖ１１１３、Ｖ１１１４、Ｖ１１１５、Ｖ１１１６、Ｖ１１１７、Ｖ１１１８、Ｖ１１１９、Ｖ１１２０、Ｖ１１２１、Ｖ１１２２、Ｖ１１２３、Ｖ１１２４、Ｖ１１２５、Ｖ１１２６、Ｖ１１２７、Ｖ１１２８、Ｖ１１２９、Ｖ１１３０、Ｖ１１３１、Ｖ１１３２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ１０８７、Ｖ１０８８及び／又はＶ１０９６、Ｖ１０９７及び／又はＶ１１０９、Ｖ１１１０及び／又はＶ１１１６、Ｖ１１１７及び／又はＶ１１２５、Ｖ１１２６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｍ）ＮＺ８Ｚ９、
その際、Ｚ８、Ｚ９は、互いに無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−Ｖ１１３３、−Ｃ（Ｏ）Ｏ−Ｖ１１３４、−Ｃ（Ｏ）−ＮＶ１１３５Ｖ１１３６、−Ｓ（Ｏ₂）−Ｖ１１３７、−Ｓ（Ｏ₂）Ｏ−Ｖ１１３８"；
その際、Ｖ１１３３、Ｖ１１３４、Ｖ１１３５、Ｖ１１３６、Ｖ１１３７、Ｖ１１３８は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｖ１１３５、Ｖ１１３６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ１１３９、−ＮＶ１１４０Ｖ１１４１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ１１４２、−Ｃ（Ｏ）Ｏ−Ｖ１１４３、−Ｃ（Ｏ）ＮＨ−Ｖ１１４４、−Ｃ（Ｏ）ＮＶ１１４５Ｖ１１４６、−Ｏ−Ｖ１１４７、−Ｏ（−Ｖ１１４８−Ｏ）_l−Ｈ（ｌ＝１、２、３、４、５）、−Ｏ（−Ｖ１１４９−Ｏ）_l−Ｖ１１５０（ｌ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ１１５１、−ＯＣ（Ｏ）−Ｏ−Ｖ１１５２、−ＯＣ（Ｏ）−ＮＨＶ１１５３、−Ｏ−Ｃ（Ｏ）−ＮＶ１１５４Ｖ１１５５、−ＯＰ（Ｏ）（ＯＶ１１５６）（ＯＶ１１５７）、−ＯＳｉ（Ｖ１１５８）（Ｖ１１５９）（Ｖ１１６０）、−ＯＳ（Ｏ₂）−Ｖ１１６１、−ＮＨＣ（Ｏ）−Ｖ１１６２、−ＮＶ１１６３Ｃ（Ｏ）−Ｖ１１６４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１１６５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１１６６、−ＮＨ−Ｃ（Ｏ）−ＮＶ１１６７Ｖ１１６８、−ＮＶ１１６９−Ｃ（Ｏ）−Ｏ−Ｖ１１７０、−ＮＶ１１７１−Ｃ（Ｏ）−ＮＨ−Ｖ１１７２、−ＮＶ１１７３−Ｃ（Ｏ）−ＮＶ１１７４Ｖ１１７５、−ＮＨＳ（Ｏ₂）−Ｖ１１７６、−ＮＶ１１７７Ｓ（Ｏ₂）−Ｖ１１７８、−Ｓ−Ｖ１１７９、−Ｓ（Ｏ）−Ｖ１１８０、−Ｓ（Ｏ₂）−Ｖ１１８１、−Ｓ（Ｏ₂）ＮＨ−Ｖ１１８２、−Ｓ（Ｏ₂）ＮＶ１１８３Ｖ１１８４、−Ｓ（Ｏ₂）Ｏ−Ｖ１１８５、−Ｐ（Ｏ）（ＯＶ１１８６）（ＯＶ１１８７）、−Ｓｉ（Ｖ１１８８）（Ｖ１１８９）（Ｖ１１９０）"；
その際、Ｖ１１３９、Ｖ１１４０、Ｖ１１４１、Ｖ１１４２、Ｖ１１４３、Ｖ１１４４、Ｖ１１４５、Ｖ１１４６、Ｖ１１４７、Ｖ１１４８、Ｖ１１４９、Ｖ１１５０、Ｖ１１５１、Ｖ１１５２、Ｖ１１５３、Ｖ１１５４、Ｖ１１５５、Ｖ１１５６、Ｖ１１５７、Ｖ１１５８、Ｖ１１５９、Ｖ１１６０、Ｖ１１６１、Ｖ１１６２、Ｖ１１６３、Ｖ１１６４、Ｖ１１６５、Ｖ１１６６、Ｖ１１６７、Ｖ１１６８、Ｖ１１６９、Ｖ１１７０、Ｖ１１７１、Ｖ１１７２、Ｖ１１７３、Ｖ１１７４、Ｖ１１７５、Ｖ１１７６、Ｖ１１７７、Ｖ１１７８、Ｖ１１７９、Ｖ１１８０、Ｖ１１８１、Ｖ１１８２、Ｖ１１８３、Ｖ１１８４、Ｖ１１８５、Ｖ１１８６、Ｖ１１８７、Ｖ１１８８、Ｖ１１８９、Ｖ１１９０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ１１４５、Ｖ１１４６及び／又はＶ１１５４、Ｖ１１５５及び／又はＶ１１６７、Ｖ１１６８及び／又はＶ１１７４、Ｖ１１７５及び／又はＶ１１８３、Ｖ１１８４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＶ１１９１、−ＮＶ１１９２Ｖ１１９３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｖ１１９４、−Ｃ（Ｏ）Ｏ−Ｖ１１９５、−Ｃ（Ｏ）ＮＨ−Ｖ１１９６、−Ｃ（Ｏ）ＮＶ１１９７Ｖ１１９８、−Ｏ−Ｖ１１９９、−Ｏ（−Ｖ１２００−Ｏ）_m−Ｈ（ｍ＝１、２、３、４、５）、−Ｏ（−Ｖ１２０１−Ｏ）_m−Ｖ１２０２（ｍ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｖ１２０３、−ＯＣ（Ｏ）−Ｏ−Ｖ１２０４、−ＯＣ（Ｏ）−ＮＨＶ１２０５、−Ｏ−Ｃ（Ｏ）−ＮＶ１２０６Ｖ１２０７、−ＯＰ（Ｏ）（ＯＶ１２０８）（ＯＶ１２０９）、−ＯＳｉ（Ｖ１２１０）（Ｖ１２１１）（Ｖ１２１２）、−ＯＳ（Ｏ₂）−Ｖ１２１３、−ＮＨＣ（Ｏ）−Ｖ１２１４、−ＮＶ１２１５Ｃ（Ｏ）−Ｖ１２１６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｖ１２１７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｖ１２１８、−ＮＨ−Ｃ（Ｏ）−ＮＶ１２１９Ｖ１２２０、−ＮＶ１２２１−Ｃ（Ｏ）−Ｏ−Ｖ１２２２、−ＮＶ１２２３−Ｃ（Ｏ）−ＮＨ−Ｖ１２２４、−ＮＶ１２２５−Ｃ（Ｏ）−ＮＶ１２２６Ｖ１２２７、−ＮＨＳ（Ｏ₂）−Ｖ１２２８、−ＮＶ１２２９Ｓ（Ｏ₂）−Ｖ１２３０、−Ｓ−Ｖ１２３１、−Ｓ（Ｏ）−Ｖ１２３２、−Ｓ（Ｏ₂）−Ｖ１２３３、−Ｓ（Ｏ₂）ＮＨ−Ｖ１２３４、−Ｓ（Ｏ₂）ＮＶ１２３５Ｖ１２３６、−Ｓ（Ｏ₂）Ｏ−Ｖ１２３７、−Ｐ（Ｏ）（ＯＶ１２３８）（ＯＶ１２３９）、−Ｓｉ（Ｖ１２４０）（Ｖ１２４１）（Ｖ１２４２）"；
その際、Ｖ１１９１、Ｖ１１９２、Ｖ１１９３、Ｖ１１９４、Ｖ１１９５、Ｖ１１９６、Ｖ１１９７、Ｖ１１９８、Ｖ１１９９、Ｖ１２００、Ｖ１２０１、Ｖ１２０２、Ｖ１２０３、Ｖ１２０４、Ｖ１２０５、Ｖ１２０６、Ｖ１２０７、Ｖ１２０８、Ｖ１２０９、Ｖ１２１０、Ｖ１２１１、Ｖ１２１２、Ｖ１２１３、Ｖ１２１４、Ｖ１２１５、Ｖ１２１６、Ｖ１２１７、Ｖ１２１８、Ｖ１２１９、Ｖ１２２０、Ｖ１２２１、Ｖ１２２２、Ｖ１２２３、Ｖ１２２４、Ｖ１２２５、Ｖ１２２６、Ｖ１２２７、Ｖ１２２８、Ｖ１２２９、Ｖ１２３０、Ｖ１２３１、Ｖ１２３２、Ｖ１２３３、Ｖ１２３４、Ｖ１２３５、Ｖ１２３６、Ｖ１２３７、Ｖ１２３８、Ｖ１２３９、Ｖ１２４０、Ｖ１２４１、Ｖ１２４２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＶ１１９７、Ｖ１１９８及び／又はＶ１２０６、Ｖ１２０７及び／又はＶ１２１９、Ｖ１２２０及び／又はＶ１２２６、Ｖ１２２７及び／又はＶ１２３５、Ｖ１２３６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
又は
（Ｃ）
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、"置換されたアルキル"であり、その際、"置換されたアルキル"は、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されている：
（ａ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１、−ＮＷ２Ｗ３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ４、−Ｃ（Ｏ）Ｏ−Ｗ５、−Ｃ（Ｏ）ＮＨ−Ｗ６、−Ｃ（Ｏ）ＮＷ７Ｗ８、−Ｏ−Ｗ９、−Ｏ（−Ｗ１０−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｗ１１−Ｏ）_r−Ｗ１２（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１３、−ＯＣ（Ｏ）−Ｏ−Ｗ１４、−ＯＣ（Ｏ）−ＮＨＷ１５、−Ｏ−Ｃ（Ｏ）−ＮＷ１６Ｗ１７、−ＯＰ（Ｏ）（ＯＷ１８）（ＯＷ１９）、−ＯＳｉ（Ｗ２０）（Ｗ２１）（Ｗ２２）、−ＯＳ（Ｏ₂）−Ｗ２３、−ＮＨＣ（Ｏ）−Ｗ２４、−ＮＷ２５Ｃ（Ｏ）−Ｗ２６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ２７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ２８、−ＮＨ−Ｃ（Ｏ）−ＮＷ２９Ｗ３０、−ＮＷ３１−Ｃ（Ｏ）−Ｏ−Ｗ３２、−ＮＷ３３−Ｃ（Ｏ）−ＮＨ−Ｗ３４、−ＮＷ３５−Ｃ（Ｏ）−ＮＷ３６Ｗ３７、−ＮＨＳ（Ｏ₂）−Ｗ３８、−ＮＷ３９Ｓ（Ｏ₂）−Ｗ４０、−Ｓ−Ｗ４１、−Ｓ（Ｏ）−Ｗ４２、−Ｓ（Ｏ₂）−Ｗ４３、−Ｓ（Ｏ₂）ＮＨ−Ｗ４４、−Ｓ（Ｏ₂）ＮＷ４５Ｗ４６、−Ｓ（Ｏ₂）Ｏ−Ｗ４７、−Ｐ（Ｏ）（ＯＷ４８）（ＯＷ４９）、−Ｓｉ（Ｗ５０）（Ｗ５１）（Ｗ５２）"；
その際、Ｗ１、Ｗ２、Ｗ３、Ｗ４、Ｗ５、Ｗ６、Ｗ７、Ｗ８、Ｗ９、Ｗ１０、Ｗ１１、Ｗ１２、Ｗ１３、Ｗ１４、Ｗ１５、Ｗ１６、Ｗ１７、Ｗ１８、Ｗ１９、Ｗ２０、Ｗ２１、Ｗ２２、Ｗ２３、Ｗ２４、Ｗ２５、Ｗ２６、Ｗ２７、Ｗ２８、Ｗ２９、Ｗ３０、Ｗ３１、Ｗ３２、Ｗ３３、Ｗ３４、Ｗ３５、Ｗ３６、Ｗ３７、Ｗ３８、Ｗ３９、Ｗ４０、Ｗ４１、Ｗ４２、Ｗ４３、Ｗ４４、Ｗ４５、Ｗ４６、Ｗ４７、Ｗ４８、Ｗ４９、Ｗ５０、Ｗ５１、Ｗ５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｗ７、Ｗ８及び／又はＷ１６、Ｗ１７及び／又はＷ２９、Ｗ３０及び／又はＷ３６、Ｗ３７及び／又はＷ４５、Ｗ４６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
但し、"−Ｃ（Ｏ）ＮＨ−アリール"、"−Ｃ（Ｏ）ＮＨ−ヘテロアリール"、"−Ｃ（Ｏ）ＮＨ−シクロアルキル"、"−Ｃ（Ｏ）ＮＨ−ヘテロシクリル"は、以下の置換基群（ｉ）から選択される少なくとも１つの置換基によって更に置換されている；
その際、場合により、置換基群（ａ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ５３、−ＮＷ５４Ｗ５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ５６、−Ｃ（Ｏ）Ｏ−Ｗ５７、−Ｃ（Ｏ）ＮＨ−Ｗ５８、−Ｃ（Ｏ）ＮＷ５９Ｗ６０、−Ｏ−Ｗ６１、−Ｏ（−Ｗ６２−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ｗ６３−Ｏ）_s−Ｗ６４（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ６５、−ＯＣ（Ｏ）−Ｏ−Ｗ６６、−ＯＣ（Ｏ）−ＮＨＷ６７、−Ｏ−Ｃ（Ｏ）−ＮＷ６８Ｗ６９、−ＯＰ（Ｏ）（ＯＷ７０）（ＯＷ７１）、−ＯＳｉ（Ｗ７２）（Ｗ７３）（Ｗ７４）、−ＯＳ（Ｏ₂）−Ｗ７５、−ＮＨＣ（Ｏ）−Ｗ７６、−ＮＷ７７Ｃ（Ｏ）−Ｗ７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ８０、−ＮＨ−Ｃ（Ｏ）−ＮＷ８１Ｗ８２、−ＮＷ８３−Ｃ（Ｏ）−Ｏ−Ｗ８４、−ＮＷ８５−Ｃ（Ｏ）−ＮＨ−Ｗ８６、−ＮＷ８７−Ｃ（Ｏ）−ＮＷ８８Ｗ８９、−ＮＨＳ（Ｏ₂）−Ｗ９０、−ＮＷ９１Ｓ（Ｏ₂）−Ｗ９２、−Ｓ−Ｗ９３、−Ｓ（Ｏ）−Ｗ９４、−Ｓ（Ｏ₂）−Ｗ９５、−Ｓ（Ｏ₂）ＮＨ−Ｗ９６、−Ｓ（Ｏ₂）ＮＷ９７Ｗ９８、−Ｓ（Ｏ₂）Ｏ−Ｗ９９、−Ｐ（Ｏ）（ＯＷ１００）（ＯＷ１０１）、−Ｓｉ（Ｗ１０２）（Ｗ１０３）（Ｗ１０４）"；
その際、Ｗ５３、Ｗ５４、Ｗ５５、Ｗ５６、Ｗ５７、Ｗ５８、Ｗ５９、Ｗ６０、Ｗ６１、Ｗ６２、Ｗ６３、Ｗ６４、Ｗ６５、Ｗ６６、Ｗ６７、Ｗ６８、Ｗ６９、Ｗ７０、Ｗ７１、Ｗ７２、Ｗ７３、Ｗ７４、Ｗ７５、Ｗ７６、Ｗ７７、Ｗ７８、Ｗ７９、Ｗ８０、Ｗ８１、Ｗ８２、Ｗ８３、Ｗ８４、Ｗ８５、Ｗ８６、Ｗ８７、Ｗ８８、Ｗ８９、Ｗ９０、Ｗ９１、Ｗ９２、Ｗ９３、Ｗ９４、Ｗ９５、Ｗ９６、Ｗ９７、Ｗ９８、Ｗ９９、Ｗ１００、Ｗ１０１、Ｗ１０２、Ｗ１０３、Ｗ１０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ５９、Ｗ６０及び／又はＷ６８、Ｗ６９及び／又はＷ８１、Ｗ８２及び／又はＷ８８、Ｗ８９及び／又はＷ９７、Ｗ９８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１０５、−ＮＷ１０６Ｗ１０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ１０８、−Ｃ（Ｏ）Ｏ−Ｗ１０９、−Ｃ（Ｏ）ＮＨ−Ｗ１１０、−Ｃ（Ｏ）ＮＷ１１１Ｗ１１２、−Ｏ−Ｗ１１３、−Ｏ（−Ｗ１１４−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｗ１１５−Ｏ）_t−Ｗ１１６（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１１７、−ＯＣ（Ｏ）−Ｏ−Ｗ１１８、−ＯＣ（Ｏ）−ＮＨＷ１１９、−Ｏ−Ｃ（Ｏ）−ＮＷ１２０Ｗ１２１、−ＯＰ（Ｏ）（ＯＷ１２２）（ＯＷ１２３）、−ＯＳｉ（Ｗ１２４）（Ｗ１２５）（Ｗ１２６）、−ＯＳ（Ｏ₂）−Ｗ１２７、−ＮＨＣ（Ｏ）−Ｗ１２８、−ＮＷ１２９Ｃ（Ｏ）−Ｗ１３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１３２、−ＮＨ−Ｃ（Ｏ）−ＮＷ１３３Ｗ１３４、−ＮＷ１３５−Ｃ（Ｏ）−Ｏ−Ｗ１３６、−ＮＷ１３７−Ｃ（Ｏ）−ＮＨ−Ｗ１３８、−ＮＷ１３９−Ｃ（Ｏ）−ＮＷ１４０Ｗ１４１、−ＮＨＳ（Ｏ₂）−Ｗ１４２、−ＮＷ１４３Ｓ（Ｏ₂）−Ｗ１４４、−Ｓ−Ｗ１４５、−Ｓ（Ｏ）−Ｗ１４６、−Ｓ（Ｏ₂）−Ｗ１４７、−Ｓ（Ｏ₂）ＮＨ−Ｗ１４８、−Ｓ（Ｏ₂）ＮＷ１４９Ｗ１５０、−Ｓ（Ｏ₂）Ｏ−Ｗ１５１、−Ｐ（Ｏ）（ＯＷ１５２）（ＯＷ１５３）、−Ｓｉ（Ｗ１５４）（Ｗ１５５）（Ｗ１５６）"；
その際、Ｗ１０５、Ｗ１０６、Ｗ１０７、Ｗ１０８、Ｗ１０９、Ｗ１１０、Ｗ１１１、Ｗ１１２、Ｗ１１３、Ｗ１１４、Ｗ１１５、Ｗ１１６、Ｗ１１７、Ｗ１１８、Ｗ１１９、Ｗ１２０、Ｗ１２１、Ｗ１２２、Ｗ１２３、Ｗ１２４、Ｗ１２５、Ｗ１２６、Ｗ１２７、Ｗ１２８、Ｗ１２９、Ｗ１３０、Ｗ１３１、Ｗ１３２、Ｗ１３３、Ｗ１３４、Ｗ１３５、Ｗ１３６、Ｗ１３７、Ｗ１３８、Ｗ１３９、Ｗ１４０、Ｗ１４１、Ｗ１４２、Ｗ１４３、Ｗ１４４、Ｗ１４５、Ｗ１４６、Ｗ１４７、Ｗ１４８、Ｗ１４９、Ｗ１５０、Ｗ１５１、Ｗ１５２、Ｗ１５３、Ｗ１５４、Ｗ１５５、Ｗ１５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ１１１、Ｗ１１２及び／又はＷ１２０、Ｗ１２１及び／又はＷ１３３、Ｗ１３４及び／又はＷ１４０、Ｗ１４１及び／又はＷ１４９、Ｗ１５０は、一緒になって、"ヘテロシクリル"を形成することもできる；
又は、
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、"Ｃ₉〜Ｃ₃₀−アルキル"である；
その際、"Ｃ₉〜Ｃ₃₀−アルキル"は、場合により、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１５７、−ＮＷ１５８Ｗ１５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ１６０、−Ｃ（Ｏ）Ｏ−Ｗ１６１、−Ｃ（Ｏ）ＮＨ−Ｗ１６２、−Ｃ（Ｏ）ＮＷ１６３Ｗ１６４、−Ｏ−Ｗ１６５、−Ｏ（−Ｗ１６６−Ｏ）_u−Ｈ（ｕ＝１、２、３、４、５）、−Ｏ（−Ｗ１６７−Ｏ）_u−Ｗ１６８（ｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１６９、−ＯＣ（Ｏ）−Ｏ−Ｗ１７０、−ＯＣ（Ｏ）−ＮＨＷ１７１、−Ｏ−Ｃ（Ｏ）−ＮＷ１７２Ｗ１７３、−ＯＰ（Ｏ）（ＯＷ１７４）（ＯＷ１７５）、−ＯＳｉ（Ｗ１７６）（Ｗ１７７）（Ｗ１７８）、−ＯＳ（Ｏ₂）−Ｗ１７９、−ＮＨＣ（Ｏ）−Ｗ１８０、−ＮＷ１８１Ｃ（Ｏ）−Ｗ１８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１８４、−ＮＨ−Ｃ（Ｏ）−ＮＷ１８５Ｗ１８６、−ＮＷ１８７−Ｃ（Ｏ）−Ｏ−Ｗ１８８、−ＮＷ１８９−Ｃ（Ｏ）−ＮＨ−Ｗ１９０、−ＮＷ１９１−Ｃ（Ｏ）−ＮＷ１９２Ｗ１９３、−ＮＨＳ（Ｏ₂）−Ｗ１９４、−ＮＷ１９５Ｓ（Ｏ₂）−Ｗ１９６、−Ｓ−Ｗ１９７、−Ｓ（Ｏ）−Ｗ１９８、−Ｓ（Ｏ₂）−Ｗ１９９、−Ｓ（Ｏ₂）ＮＨ−Ｗ２００、−Ｓ（Ｏ₂）ＮＷ２０１Ｗ２０２、−Ｓ（Ｏ₂）Ｏ−Ｗ２０３、−Ｐ（Ｏ）（ＯＷ２０４）（ＯＷ２０５）、−Ｓｉ（Ｗ２０６）（Ｗ２０７）（Ｗ２０８）"；
その際、Ｗ１５７、Ｗ１５８、Ｗ１５９、Ｗ１６０、Ｗ１６１、Ｗ１６２、Ｗ１６３、Ｗ１６４、Ｗ１６５、Ｗ１６６、Ｗ１６７、Ｗ１６８、Ｗ１６９、Ｗ１７０、Ｗ１７１、Ｗ１７２、Ｗ１７３、Ｗ１７４、Ｗ１７５、Ｗ１７６、Ｗ１７７、Ｗ１７８、Ｗ１７９、Ｗ１８０、Ｗ１８１、Ｗ１８２、Ｗ１８３、Ｗ１８４、Ｗ１８５、Ｗ１８６、Ｗ１８７、Ｗ１８８、Ｗ１８９、Ｗ１９０、Ｗ１９１、Ｗ１９２、Ｗ１９３、Ｗ１９４、Ｗ１９５、Ｗ１９６、Ｗ１９７、Ｗ１９８、Ｗ１９９、Ｗ２００、Ｗ２０１、Ｗ２０２、Ｗ２０３、Ｗ２０４、Ｗ２０５、Ｗ２０６、Ｗ２０７、Ｗ２０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ１６３、Ｗ１６４及び／又はＷ１７２、Ｗ１７３及び／又はＷ１８５、Ｗ１８６及び／又はＷ１９２、Ｗ１９３及び／又はＷ２０１、Ｗ２０２は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記の置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ２０９、−ＮＷ２１０Ｗ２１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ２１２、−Ｃ（Ｏ）Ｏ−Ｗ２１３、−Ｃ（Ｏ）ＮＨ−Ｗ２１４、−Ｃ（Ｏ）ＮＷ２１５Ｗ２１６、−Ｏ−Ｗ２１７、−Ｏ（−Ｗ２１８−Ｏ）_v−Ｈ（ｖ＝１、２、３、４、５）、−Ｏ（−Ｗ２１９−Ｏ）_v−Ｗ２２０（ｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ２２１、−ＯＣ（Ｏ）−Ｏ−Ｗ２２２、−ＯＣ（Ｏ）−ＮＨＷ２２３、−Ｏ−Ｃ（Ｏ）−ＮＷ２２４Ｗ２２５、−ＯＰ（Ｏ）（ＯＷ２２６）（ＯＷ２２７）、−ＯＳｉ（Ｗ２２８）（Ｗ２２９）（Ｗ２３０）、−ＯＳ（Ｏ₂）−Ｗ２３１、−ＮＨＣ（Ｏ）−Ｗ２３２、−ＮＷ２３３Ｃ（Ｏ）−Ｗ２３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ２３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ２３６、−ＮＨ−Ｃ（Ｏ）−ＮＷ２３７Ｗ２３８、−ＮＷ２３９−Ｃ（Ｏ）−Ｏ−Ｗ２４０、−ＮＷ２４１−Ｃ（Ｏ）−ＮＨ−Ｗ２４２、−ＮＷ２４３−Ｃ（Ｏ）−ＮＷ２４４Ｗ２４５、−ＮＨＳ（Ｏ₂）−Ｗ２４６、−ＮＷ２４７Ｓ（Ｏ₂）−Ｗ２４８、−Ｓ−Ｗ２４９、−Ｓ（Ｏ）−Ｗ２５０、−Ｓ（Ｏ₂）−Ｗ２５１、−Ｓ（Ｏ₂）ＮＨ−Ｗ２５２、−Ｓ（Ｏ₂）ＮＷ２５３Ｗ２５４、−Ｓ（Ｏ₂）Ｏ−Ｗ２５５、−Ｐ（Ｏ）（ＯＷ２５６）（ＯＷ２５７）、−Ｓｉ（Ｗ２５８）（Ｗ２５９）（Ｗ２６０）"；
その際、Ｗ２０９、Ｗ２１０、Ｗ２１１、Ｗ２１２、Ｗ２１３、Ｗ２１４、Ｗ２１５、Ｗ２１６、Ｗ２１７、Ｗ２１８、Ｗ２１９、Ｗ２２０、Ｗ２２１、Ｗ２２２、Ｗ２２３、Ｗ２２４、Ｗ２２５、Ｗ２２６、Ｗ２２７、Ｗ２２８、Ｗ２２９、Ｗ２３０、Ｗ２３１、Ｗ２３２、Ｗ２３３、Ｗ２３４、Ｗ２３５、Ｗ２３６、Ｗ２３７、Ｗ２３８、Ｗ２３９、Ｗ２４０、Ｗ２４１、Ｗ２４２、Ｗ２４３、Ｗ２４４、Ｗ２４５、Ｗ２４６、Ｗ２４７、Ｗ２４８、Ｗ２４９、Ｗ２５０、Ｗ２５１、Ｗ２５２、Ｗ２５３、Ｗ２５４、Ｗ２５５、Ｗ２５６、Ｗ２５７、Ｗ２５８、Ｗ２５９、Ｗ２６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｗ２１５、Ｗ２１６及び／又はＷ２２４、Ｗ２２５及び／又はＷ２３７、Ｗ２３８及び／又はＷ２４４、Ｗ２４５及び／又はＷ２５３、Ｗ２５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ３、Ｚ４の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ３、Ｚ４のどちらも、以下のものからなる群から選択されない：
（ｂ）水素；
（ｃ）ハロゲン、Ｆ、Ｃｌ、Ｂｒ、Ｉ；
（ｄ）非置換もしくは置換されたアルキルもしくはＣ₉〜Ｃ₃₀−アルキル、
その際、場合により、前記のアルキル基もしくはＣ₉〜Ｃ₃₀−アルキル基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ４５７、−ＮＷ４５８Ｗ４５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ４６０、−Ｃ（Ｏ）Ｏ−Ｗ４６１、−Ｃ（Ｏ）ＮＨ−Ｗ４６２、−Ｃ（Ｏ）ＮＷ４６３Ｗ４６４、−Ｏ−Ｗ４６５、−Ｏ（−Ｗ４６６−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−Ｏ（−Ｗ４６７−Ｏ）_x−Ｗ４６８（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ４６９、−ＯＣ（Ｏ）−Ｏ−Ｗ４７０、−ＯＣ（Ｏ）−ＮＨＷ４７１、−Ｏ−Ｃ（Ｏ）−ＮＷ４７２Ｗ４７３、−ＯＰ（Ｏ）（ＯＷ４７４）（ＯＷ４７５）、−ＯＳｉ（Ｗ４７６）（Ｗ４７７）（Ｗ４７８）、−ＯＳ（Ｏ₂）−Ｗ４７９、−ＮＨＣ（Ｏ）−Ｗ４８０、−ＮＷ４８１Ｃ（Ｏ）−Ｗ４８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ４８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ４８４、−ＮＨ−Ｃ（Ｏ）−ＮＷ４８５Ｗ４８６、−ＮＷ４８７−Ｃ（Ｏ）−Ｏ−Ｗ４８８、−ＮＷ４８９−Ｃ（Ｏ）−ＮＨ−Ｗ４９０、−ＮＷ４９１−Ｃ（Ｏ）−ＮＷ４９２Ｗ４９３、−ＮＨＳ（Ｏ₂）−Ｗ４９４、−ＮＷ４９５Ｓ（Ｏ₂）−Ｗ４９６、−Ｓ−Ｗ４９７、−Ｓ（Ｏ）−Ｗ４９８、−Ｓ（Ｏ₂）−Ｗ４９９、−Ｓ（Ｏ₂）ＮＨ−Ｗ５００、−Ｓ（Ｏ₂）ＮＷ５０１Ｗ５０２、−Ｓ（Ｏ₂）Ｏ−Ｗ５０３、−Ｐ（Ｏ）（ＯＷ５０４）（ＯＷ５０５）、−Ｓｉ（Ｗ５０６）（Ｗ５０７）（Ｗ５０８）"；
その際、Ｗ４５７、Ｗ４５８、Ｗ４５９、Ｗ４６０、Ｗ４６１、Ｗ４６２、Ｗ４６３、Ｗ４６４、Ｗ４６５、Ｗ４６６、Ｗ４６７、Ｗ４６８、Ｗ４６９、Ｗ４７０、Ｗ４７１、Ｗ４７２、Ｗ４７３、Ｗ４７４、Ｗ４７５、Ｗ４７６、Ｗ４７７、Ｗ４７８、Ｗ４７９、Ｗ４８０、Ｗ４８１、Ｗ４８２、Ｗ４８３、Ｗ４８４、Ｗ４８５、Ｗ４８６、Ｗ４８７、Ｗ４８８、Ｗ４８９、Ｗ４９０、Ｗ４９１、Ｗ４９２、Ｗ４９３、Ｗ４９４、Ｗ４９５、Ｗ４９６、Ｗ４９７、Ｗ４９８、Ｗ４９９、Ｗ５００、Ｗ５０１、Ｗ５０２、Ｗ５０３、Ｗ５０４、Ｗ５０５、Ｗ５０６、Ｗ５０７、Ｗ５０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ４６３、Ｗ４６４及び／又はＷ４７２、Ｗ４７３及び／又はＷ４８５、Ｗ４８６及び／又はＷ４９２、Ｗ４９３及び／又はＷ５０１、Ｗ５０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ５０９、−ＮＷ５１０Ｗ５１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ５１２、−Ｃ（Ｏ）Ｏ−Ｗ５１３、−Ｃ（Ｏ）ＮＨ−Ｗ５１４、−Ｃ（Ｏ）ＮＷ５１５Ｗ５１６、−Ｏ−Ｗ５１７、−Ｏ（−Ｗ５１８−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｗ５１９−Ｏ）_y−Ｗ５２０（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ５２１、−ＯＣ（Ｏ）−Ｏ−Ｗ５２２、−ＯＣ（Ｏ）−ＮＨＷ５２３、−Ｏ−Ｃ（Ｏ）−ＮＷ５２４Ｗ５２５、−ＯＰ（Ｏ）（ＯＷ５２６）（ＯＷ５２７）、−ＯＳｉ（Ｗ５２８）（Ｗ５２９）（Ｗ５３０）、−ＯＳ（Ｏ₂）−Ｗ５３１、−ＮＨＣ（Ｏ）−Ｗ５３２、−ＮＷ５３３Ｃ（Ｏ）−Ｗ５３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ５３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ５３６、−ＮＨ−Ｃ（Ｏ）−ＮＷ５３７Ｗ５３８、−ＮＷ５３９−Ｃ（Ｏ）−Ｏ−Ｗ５４０、−ＮＷ５４１−Ｃ（Ｏ）−ＮＨ−Ｗ５４２、−ＮＷ５４３−Ｃ（Ｏ）−ＮＷ５４４Ｗ５４５、−ＮＨＳ（Ｏ₂）−Ｗ５４６、−ＮＷ５４７Ｓ（Ｏ₂）−Ｗ５４８、−Ｓ−Ｗ５４９、−Ｓ（Ｏ）−Ｗ５５０、−Ｓ（Ｏ₂）−Ｗ５５１、−Ｓ（Ｏ₂）ＮＨ−Ｗ５５２、−Ｓ（Ｏ₂）ＮＷ５５３Ｗ５５４、−Ｓ（Ｏ₂）Ｏ−Ｗ５５５、−Ｐ（Ｏ）（ＯＷ５５６）（ＯＷ５５７）、−Ｓｉ（Ｗ５５８）（Ｗ５５９）（Ｗ５６０）"；
その際、Ｗ５０９、Ｗ５１０、Ｗ５１１、Ｗ５１２、Ｗ５１３、Ｗ５１４、Ｗ５１５、Ｗ５１６、Ｗ５１７、Ｗ５１８、Ｗ５１９、Ｗ５２０、Ｗ５２１、Ｗ５２２、Ｗ５２３、Ｗ５２４、Ｗ５２５、Ｗ５２６、Ｗ５２７、Ｗ５２８、Ｗ５２９、Ｗ５３０、Ｗ５３１、Ｗ５３２、Ｗ５３３、Ｗ５３４、Ｗ５３５、Ｗ５３６、Ｗ５３７、Ｗ５３８、Ｗ５３９、Ｗ５４０、Ｗ５４１、Ｗ５４２、Ｗ５４３、Ｗ５４４、Ｗ５４５、Ｗ５４６、Ｗ５４７、Ｗ５４８、Ｗ５４９、Ｗ５５０、Ｗ５５１、Ｗ５５２、Ｗ５５３、Ｗ５５４、Ｗ５５５、Ｗ５５６、Ｗ５５７、Ｗ５５８、Ｗ５５９、Ｗ５６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ５１５、Ｗ５１６及び／又はＷ５２４、Ｗ５２５及び／又はＷ５３７、Ｗ５３８及び／又はＷ５４４、Ｗ５４５及び／又はＷ５５３、Ｗ５５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ５６１、−ＮＷ５６２Ｗ５６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ５６４、−Ｃ（Ｏ）Ｏ−Ｗ５６５、−Ｃ（Ｏ）ＮＨ−Ｗ５６６、−Ｃ（Ｏ）ＮＷ５６７Ｗ５６８、−Ｏ−Ｗ５６９、−Ｏ（−Ｗ５７０−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｗ５７１−Ｏ）_z−Ｗ５７２（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ５７３、−ＯＣ（Ｏ）−Ｏ−Ｗ５７４、−ＯＣ（Ｏ）−ＮＨＷ５７５、−Ｏ−Ｃ（Ｏ）−ＮＷ５７６Ｗ５７７、−ＯＰ（Ｏ）（ＯＷ５７８）（ＯＷ５７９）、−ＯＳｉ（Ｗ５８０）（Ｗ５８１）（Ｗ５８２）、−ＯＳ（Ｏ₂）−Ｗ５８３、−ＮＨＣ（Ｏ）−Ｗ５８４、−ＮＷ５８５Ｃ（Ｏ）−Ｗ５８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ５８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ５８８、−ＮＨ−Ｃ（Ｏ）−ＮＷ５８９Ｗ５９０、−ＮＷ５９１−Ｃ（Ｏ）−Ｏ−Ｗ５９２、−ＮＷ５９３−Ｃ（Ｏ）−ＮＨ−Ｗ５９４、−ＮＷ５９５−Ｃ（Ｏ）−ＮＷ５９６Ｗ５９７、−ＮＨＳ（Ｏ₂）−Ｗ５９８、−ＮＷ５９９Ｓ（Ｏ₂）−Ｗ６００、−Ｓ−Ｗ６０１、−Ｓ（Ｏ）−Ｗ６０２、−Ｓ（Ｏ₂）−Ｗ６０３、−Ｓ（Ｏ₂）ＮＨ−Ｗ６０４、−Ｓ（Ｏ₂）ＮＷ６０５Ｗ６０６、−Ｓ（Ｏ₂）Ｏ−Ｗ６０７、−Ｐ（Ｏ）（ＯＷ６０８）（ＯＷ６０９）、−Ｓｉ（Ｗ６１０）（Ｗ６１１）（Ｗ６１２）"；
その際、Ｗ５６１、Ｗ５６２、Ｗ５６３、Ｗ５６４、Ｗ５６５、Ｗ５６６、Ｗ５６７、Ｗ５６８、Ｗ５６９、Ｗ５７０、Ｗ５７１、Ｗ５７２、Ｗ５７３、Ｗ５７４、Ｗ５７５、Ｗ５７６、Ｗ５７７、Ｗ５７８、Ｗ５７９、Ｗ５８０、Ｗ５８１、Ｗ５８２、Ｗ５８３、Ｗ５８４、Ｗ５８５、Ｗ５８６、Ｗ５８７、Ｗ５８８、Ｗ５８９、Ｗ５９０、Ｗ５９１、Ｗ５９２、Ｗ５９３、Ｗ５９４、Ｗ５９５、Ｗ５９６、Ｗ５９７、Ｗ５９８、Ｗ５９９、Ｗ６００、Ｗ６０１、Ｗ６０２、Ｗ６０３、Ｗ６０４、Ｗ６０５、Ｗ６０６、Ｗ６０７、Ｗ６０８、Ｗ６０９、Ｗ６１０、Ｗ６１１、Ｗ６１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ５６７、Ｗ５６８及び／又はＷ５７６、Ｗ５７７及び／又はＷ５８９、Ｗ５９０及び／又はＷ５９６、Ｗ５９７及び／又はＷ６０５、Ｗ６０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｅ）非置換もしくは置換されたアリール、
その際、場合により、前記のアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ６１３、−ＮＷ６１４Ｗ６１５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ６１６、−Ｃ（Ｏ）Ｏ−Ｗ６１７、−Ｃ（Ｏ）ＮＨ−Ｗ６１８、−Ｃ（Ｏ）ＮＷ６１９Ｗ６２０、−Ｏ−Ｗ６２１、−Ｏ（−Ｗ６２２−Ｏ）_a−Ｈ（ａ＝１、２、３、４、５）、−Ｏ（−Ｗ６２３−Ｏ）_a−Ｗ６２４（ａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ６２５、−ＯＣ（Ｏ）−Ｏ−Ｗ６２６、−ＯＣ（Ｏ）−ＮＨＷ６２７、−Ｏ−Ｃ（Ｏ）−ＮＷ６２８Ｗ６２９、−ＯＰ（Ｏ）（ＯＷ６３０）（ＯＷ６３１）、−ＯＳｉ（Ｗ６３２）（Ｗ６３３）（Ｗ６３４）、−ＯＳ（Ｏ₂）−Ｗ６３５、−ＮＨＣ（Ｏ）−Ｗ６３６、−ＮＷ６３７Ｃ（Ｏ）−Ｗ６３８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ６３９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ６４０、−ＮＨ−Ｃ（Ｏ）−ＮＷ６４１Ｗ６４２、−ＮＷ６４３−Ｃ（Ｏ）−Ｏ−Ｗ６４４、−ＮＷ６４５−Ｃ（Ｏ）−ＮＨ−Ｗ６４６、−ＮＷ６４７−Ｃ（Ｏ）−ＮＷ６４８Ｗ６４９、−ＮＨＳ（Ｏ₂）−Ｗ６５０、−ＮＷ６５１Ｓ（Ｏ₂）−Ｗ６５２、−Ｓ−Ｗ６５３、−Ｓ（Ｏ）−Ｗ６５４、−Ｓ（Ｏ₂）−Ｗ６５５、−Ｓ（Ｏ₂）ＮＨ−Ｗ６５６、−Ｓ（Ｏ₂）ＮＷ６５７Ｗ６５８、−Ｓ（Ｏ₂）Ｏ−Ｗ６５９、−Ｐ（Ｏ）（ＯＷ６６０）（ＯＷ６６１）、−Ｓｉ（Ｗ６６２）（Ｗ６６３）（Ｗ６６４）"；
その際、Ｗ６１３、Ｗ６１４、Ｗ６１５、Ｗ６１６、Ｗ６１７、Ｗ６１８、Ｗ６１９、Ｗ６２０、Ｗ６２１、Ｗ６２２、Ｗ６２３、Ｗ６２４、Ｗ６２５、Ｗ６２６、Ｗ６２７、Ｗ６２８、Ｗ６２９、Ｗ６３０、Ｗ６３１、Ｗ６３２、Ｗ６３３、Ｗ６３４、Ｗ６３５、Ｗ６３６、Ｗ６３７、Ｗ６３８、Ｗ６３９、Ｗ６４０、Ｗ６４１、Ｗ６４２、Ｗ６４３、Ｗ６４４、Ｗ６４５、Ｗ６４６、Ｗ６４７、Ｗ６４８、Ｗ６４９、Ｗ６５０、Ｗ６５１、Ｗ６５２、Ｗ６５３、Ｗ６５４、Ｗ６５５、Ｗ６５６、Ｗ６５７、Ｗ６５８、Ｗ６５９、Ｗ６６０、Ｗ６６１、Ｗ６６２、Ｗ６６３、Ｗ６６４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ６１９、Ｗ６２０及び／又はＷ６２８、Ｗ６２９及び／又はＷ６４１、Ｗ６４２及び／又はＷ６４８、Ｗ６４９及び／又はＷ６５７、Ｗ６５８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ６６５、−ＮＷ６６６Ｗ６６７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ６６８、−Ｃ（Ｏ）Ｏ−Ｗ６６９、−Ｃ（Ｏ）ＮＨ−Ｗ６７０、−Ｃ（Ｏ）ＮＷ６７１Ｗ６７２、−Ｏ−Ｗ６７３、−Ｏ（−Ｗ６７４−Ｏ）_b−Ｈ（ｂ＝１、２、３、４、５）、−Ｏ（−Ｗ６７５−Ｏ）_b−Ｗ６７６（ｂ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ６７７、−ＯＣ（Ｏ）−Ｏ−Ｗ６７８、−ＯＣ（Ｏ）−ＮＨＷ６７９、−Ｏ−Ｃ（Ｏ）−ＮＷ６８０Ｗ６８１、−ＯＰ（Ｏ）（ＯＷ６８２）（ＯＷ６８３）、−ＯＳｉ（Ｗ６８４）（Ｗ６８５）（Ｗ６８６）、−ＯＳ（Ｏ₂）−Ｗ６８７、−ＮＨＣ（Ｏ）−Ｗ６８８、−ＮＷ６８９Ｃ（Ｏ）−Ｗ６９０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ６９１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ６９２、−ＮＨ−Ｃ（Ｏ）−ＮＷ６９３Ｗ６９４、−ＮＷ６９５−Ｃ（Ｏ）−Ｏ−Ｗ６９６、−ＮＷ６９７−Ｃ（Ｏ）−ＮＨ−Ｗ６９８、−ＮＷ６９９−Ｃ（Ｏ）−ＮＷ７００Ｗ７０１、−ＮＨＳ（Ｏ₂）−Ｗ７０２、−ＮＷ７０３Ｓ（Ｏ₂）−Ｗ７０４、−Ｓ−Ｗ７０５、−Ｓ（Ｏ）−Ｗ７０６、−Ｓ（Ｏ₂）−Ｗ７０７、−Ｓ（Ｏ₂）ＮＨ−Ｗ７０８、−Ｓ（Ｏ₂）ＮＷ７０９Ｗ７１０、−Ｓ（Ｏ₂）Ｏ−Ｗ７１１、−Ｐ（Ｏ）（ＯＷ７１２）（ＯＷ７１３）、−Ｓｉ（Ｗ７１４）（Ｗ７１５）（Ｗ７１６）"；
その際、Ｗ６６５、Ｗ６６６、Ｗ６６７、Ｗ６６８、Ｗ６６９、Ｗ６７０、Ｗ６７１、Ｗ６７２、Ｗ６７３、Ｗ６７４、Ｗ６７５、Ｗ６７６、Ｗ６７７、Ｗ６７８、Ｗ６７９、Ｗ６８０、Ｗ６８１、Ｗ６８２、Ｗ６８３、Ｗ６８４、Ｗ６８５、Ｗ６８６、Ｗ６８７、Ｗ６８８、Ｗ６８９、Ｗ６９０、Ｗ６９１、Ｗ６９２、Ｗ６９３、Ｗ６９４、Ｗ６９５、Ｗ６９６、Ｗ６９７、Ｗ６９８、Ｗ６９９、Ｗ７００、Ｗ７０１、Ｗ７０２、Ｗ７０３、Ｗ７０４、Ｗ７０５、Ｗ７０６、Ｗ７０７、Ｗ７０８、Ｗ７０９、Ｗ７１０、Ｗ７１１、Ｗ７１２、Ｗ７１３、Ｗ７１４、Ｗ７１５、Ｗ７１６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ６７１、Ｗ６７２及び／又はＷ６８０、Ｗ６８１及び／又はＷ６９３、Ｗ６９４及び／又はＷ７００、Ｗ７０１及び／又はＷ７０９、Ｗ７１０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ７１７、−ＮＷ７１８Ｗ７１９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ７２０、−Ｃ（Ｏ）Ｏ−Ｗ７２１、−Ｃ（Ｏ）ＮＨ−Ｗ７２２、−Ｃ（Ｏ）ＮＷ７２３Ｗ７２４、−Ｏ−Ｗ７２５、−Ｏ（−Ｗ７２６−Ｏ）_c−Ｈ（ｃ＝１、２、３、４、５）、−Ｏ（−Ｗ７２７−Ｏ）_c−Ｗ７２８（ｃ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ７２９、−ＯＣ（Ｏ）−Ｏ−Ｗ７３０、−ＯＣ（Ｏ）−ＮＨＷ７３１、−Ｏ−Ｃ（Ｏ）−ＮＷ７３２Ｗ７３３、−ＯＰ（Ｏ）（ＯＷ７３４）（ＯＷ７３５）、−ＯＳｉ（Ｗ７３６）（Ｗ７３７）（Ｗ７３８）、−ＯＳ（Ｏ₂）−Ｗ７３９、−ＮＨＣ（Ｏ）−Ｗ７４０、−ＮＷ７４１Ｃ（Ｏ）−Ｗ７４２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ７４３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ７４４、−ＮＨ−Ｃ（Ｏ）−ＮＷ７４５Ｗ７４６、−ＮＷ７４７−Ｃ（Ｏ）−Ｏ−Ｗ７４８、−ＮＷ７４９−Ｃ（Ｏ）−ＮＨ−Ｗ７５０、−ＮＷ７５１−Ｃ（Ｏ）−ＮＷ７５２Ｗ７５３、−ＮＨＳ（Ｏ₂）−Ｗ７５４、−ＮＷ７５５Ｓ（Ｏ₂）−Ｗ７５６、−Ｓ−Ｗ７５７、−Ｓ（Ｏ）−Ｗ７５８、−Ｓ（Ｏ₂）−Ｗ７５９、−Ｓ（Ｏ₂）ＮＨ−Ｗ７６０、−Ｓ（Ｏ₂）ＮＷ７６１Ｗ７６２、−Ｓ（Ｏ₂）Ｏ−Ｗ７６３、−Ｐ（Ｏ）（ＯＷ７６４）（ＯＷ７６５）、−Ｓｉ（Ｗ７６６）（Ｗ７６７）（Ｗ７６８）"；
その際、Ｗ７１７、Ｗ７１８、Ｗ７１９、Ｗ７２０、Ｗ７２１、Ｗ７２２、Ｗ７２３、Ｗ７２４、Ｗ７２５、Ｗ７２６、Ｗ７２７、Ｗ７２８、Ｗ７２９、Ｗ７３０、Ｗ７３１、Ｗ７３２、Ｗ７３３、Ｗ７３４、Ｗ７３５、Ｗ７３６、Ｗ７３７、Ｗ７３８、Ｗ７３９、Ｗ７４０、Ｗ７４１、Ｗ７４２、Ｗ７４３、Ｗ７４４、Ｗ７４５、Ｗ７４６、Ｗ７４７、Ｗ７４８、Ｗ７４９、Ｗ７５０、Ｗ７５１、Ｗ７５２、Ｗ７５３、Ｗ７５４、Ｗ７５５、Ｗ７５６、Ｗ７５７、Ｗ７５８、Ｗ７５９、Ｗ７６０、Ｗ７６１、Ｗ７６２、Ｗ７６３、Ｗ７６４、Ｗ７６５、Ｗ７６６、Ｗ７６７、Ｗ７６８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ７２３、Ｗ７２４及び／又はＷ７３２、Ｗ７３３及び／又はＷ７４５、Ｗ７４６及び／又はＷ７５２、Ｗ７５３及び／又はＷ７６１、Ｗ７６２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｆ）非置換もしくは置換されたヘテロアリール、
その際、場合により、前記のヘテロアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ７６９、−ＮＷ７７０Ｗ７７１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ７７２、−Ｃ（Ｏ）Ｏ−Ｗ７７３、−Ｃ（Ｏ）ＮＨ−Ｗ７７４、−Ｃ（Ｏ）ＮＷ７７５Ｗ７７６、−Ｏ−Ｗ７７７、−Ｏ（−Ｗ７７８−Ｏ）_d−Ｈ（ｄ＝１、２、３、４、５）、−Ｏ（−Ｗ７７９−Ｏ）_d−Ｗ７８０（ｄ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ７８１、−ＯＣ（Ｏ）−Ｏ−Ｗ７８２、−ＯＣ（Ｏ）−ＮＨＷ７８３、−Ｏ−Ｃ（Ｏ）−ＮＷ７８４Ｗ７８５、−ＯＰ（Ｏ）（ＯＷ７８６）（ＯＷ７８７）、−ＯＳｉ（Ｗ７８８）（Ｗ７８９）（Ｗ７９０）、−ＯＳ（Ｏ₂）−Ｗ７９１、−ＮＨＣ（Ｏ）−Ｗ７９２、−ＮＷ７９３Ｃ（Ｏ）−Ｗ７９４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ７９５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ７９６、−ＮＨ−Ｃ（Ｏ）−ＮＷ７９７Ｗ７９８、−ＮＷ７９９−Ｃ（Ｏ）−Ｏ−Ｗ８００、−ＮＷ８０１−Ｃ（Ｏ）−ＮＨ−Ｗ８０２、−ＮＷ８０３−Ｃ（Ｏ）−ＮＷ８０４Ｗ８０５、−ＮＨＳ（Ｏ₂）−Ｗ８０６、−ＮＷ８０７Ｓ（Ｏ₂）−Ｗ８０８、−Ｓ−Ｗ８０９、−Ｓ（Ｏ）−Ｗ８１０、−Ｓ（Ｏ₂）−Ｗ８１１、−Ｓ（Ｏ₂）ＮＨ−Ｗ８１２、−Ｓ（Ｏ₂）ＮＷ８１３Ｗ８１４、−Ｓ（Ｏ₂）Ｏ−Ｗ８１５、−Ｐ（Ｏ）（ＯＷ８１６）（ＯＷ８１７）、−Ｓｉ（Ｗ８１８）（Ｗ８１９）（Ｗ８２０）"；
その際、Ｗ７６９、Ｗ７７０、Ｗ７７１、Ｗ７７２、Ｗ７７３、Ｗ７７４、Ｗ７７５、Ｗ７７６、Ｗ７７７、Ｗ７７８、Ｗ７７９、Ｗ７８０、Ｗ７８１、Ｗ７８２、Ｗ７８３、Ｗ７８４、Ｗ７８５、Ｗ７８６、Ｗ７８７、Ｗ７８８、Ｗ７８９、Ｗ７９０、Ｗ７９１、Ｗ７９２、Ｗ７９３、Ｗ７９４、Ｗ７９５、Ｗ７９６、Ｗ７９７、Ｗ７９８、Ｗ７９９、Ｗ８００、Ｗ８０１、Ｗ８０２、Ｗ８０３、Ｗ８０４、Ｗ８０５、Ｗ８０６、Ｗ８０７、Ｗ８０８、Ｗ８０９、Ｗ８１０、Ｗ８１１、Ｗ８１２、Ｗ８１３、Ｗ８１４、Ｗ８１５、Ｗ８１６、Ｗ８１７、Ｗ８１８、Ｗ８１９、Ｗ８２０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ７７５、Ｗ７７６及び／又はＷ７８４、Ｗ７８５及び／又はＷ７９７、Ｗ７９８及び／又はＷ８０４、Ｗ８０５及び／又はＷ８１３、Ｗ８１４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ８２１、−ＮＷ８２２Ｗ８２３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ８２４、−Ｃ（Ｏ）Ｏ−Ｗ８２５、−Ｃ（Ｏ）ＮＨ−Ｗ８２６、−Ｃ（Ｏ）ＮＷ８２７Ｗ８２８、−Ｏ−Ｗ８２９、−Ｏ（−Ｗ８３０−Ｏ）_e−Ｈ（ｅ＝１、２、３、４、５）、−Ｏ（−Ｗ８３１−Ｏ）_e−Ｗ８３２（ｅ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ８３３、−ＯＣ（Ｏ）−Ｏ−Ｗ８３４、−ＯＣ（Ｏ）−ＮＨＷ８３５、−Ｏ−Ｃ（Ｏ）−ＮＷ８３６Ｗ８３７、−ＯＰ（Ｏ）（ＯＷ８３８）（ＯＷ８３９）、−ＯＳｉ（Ｗ８４０）（Ｗ８４１）（Ｗ８４２）、−ＯＳ（Ｏ₂）−Ｗ８４３、−ＮＨＣ（Ｏ）−Ｗ８４４、−ＮＷ８４５Ｃ（Ｏ）−Ｗ８４６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ８４７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ８４８、−ＮＨ−Ｃ（Ｏ）−ＮＷ８４９Ｗ８５０、−ＮＷ８５１−Ｃ（Ｏ）−Ｏ−Ｗ８５２、−ＮＷ８５３−Ｃ（Ｏ）−ＮＨ−Ｗ８５４、−ＮＷ８５５−Ｃ（Ｏ）−ＮＷ８５６Ｗ８５７、−ＮＨＳ（Ｏ₂）−Ｗ８５８、−ＮＷ８５９Ｓ（Ｏ₂）−Ｗ８６０、−Ｓ−Ｗ８６１、−Ｓ（Ｏ）−Ｗ８６２、−Ｓ（Ｏ₂）−Ｗ８６３、−Ｓ（Ｏ₂）ＮＨ−Ｗ８６４、−Ｓ（Ｏ₂）ＮＷ８６５Ｗ８６６、−Ｓ（Ｏ₂）Ｏ−Ｗ８６７、−Ｐ（Ｏ）（ＯＷ８６８）（ＯＷ８６９）、−Ｓｉ（Ｗ８７０）（Ｗ８７１）（Ｗ８７２）"；
その際、Ｗ８２１、Ｗ８２２、Ｗ８２３、Ｗ８２４、Ｗ８２５、Ｗ８２６、Ｗ８２７、Ｗ８２８、Ｗ８２９、Ｗ８３０、Ｗ８３１、Ｗ８３２、Ｗ８３３、Ｗ８３４、Ｗ８３５、Ｗ８３６、Ｗ８３７、Ｗ８３８、Ｗ８３９、Ｗ８４０、Ｗ８４１、Ｗ８４２、Ｗ８４３、Ｗ８４４、Ｗ８４５、Ｗ８４６、Ｗ８４７、Ｗ８４８、Ｗ８４９、Ｗ８５０、Ｗ８５１、Ｗ８５２、Ｗ８５３、Ｗ８５４、Ｗ８５５、Ｗ８５６、Ｗ８５７、Ｗ８５８、Ｗ８５９、Ｗ８６０、Ｗ８６１、Ｗ８６２、Ｗ８６３、Ｗ８６４、Ｗ８６５、Ｗ８６６、Ｗ８６７、Ｗ８６８、Ｗ８６９、Ｗ８７０、Ｗ８７１、Ｗ８７２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ８２７、Ｗ８２８及び／又はＷ８３６、Ｗ８３７及び／又はＷ８４９、Ｗ８５０及び／又はＷ８５６、Ｗ８５７及び／又はＷ８６５、Ｗ８６６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ８７３、−ＮＷ８７４Ｗ８７５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ８７６、−Ｃ（Ｏ）Ｏ−Ｗ８７７、−Ｃ（Ｏ）ＮＨ−Ｗ８７８、−Ｃ（Ｏ）ＮＷ８７９Ｗ８８０、−Ｏ−Ｗ８８１、−Ｏ（−Ｗ８８２−Ｏ）_f−Ｈ（ｆ＝１、２、３、４、５）、−Ｏ（−Ｗ８８３−Ｏ）_f−Ｗ８８４（ｆ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ８８５、−ＯＣ（Ｏ）−Ｏ−Ｗ８８６、−ＯＣ（Ｏ）−ＮＨＷ８８７、−Ｏ−Ｃ（Ｏ）−ＮＷ８８８Ｗ８８９、−ＯＰ（Ｏ）（ＯＷ８９０）（ＯＷ８９１）、−ＯＳｉ（Ｗ８９２）（Ｗ８９３）（Ｗ８９４）、−ＯＳ（Ｏ₂）−Ｗ８９５、−ＮＨＣ（Ｏ）−Ｗ８９６、−ＮＷ８９７Ｃ（Ｏ）−Ｗ８９８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ８９９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ９００、−ＮＨ−Ｃ（Ｏ）−ＮＷ９０１Ｗ９０２、−ＮＷ９０３−Ｃ（Ｏ）−Ｏ−Ｗ９０４、−ＮＷ９０５−Ｃ（Ｏ）−ＮＨ−Ｗ９０６、−ＮＷ９０７−Ｃ（Ｏ）−ＮＷ９０８Ｗ９０９、−ＮＨＳ（Ｏ₂）−Ｗ９１０、−ＮＷ９１１Ｓ（Ｏ₂）−Ｗ９１２、−Ｓ−Ｗ９１３、−Ｓ（Ｏ）−Ｗ９１４、−Ｓ（Ｏ₂）−Ｗ９１５、−Ｓ（Ｏ₂）ＮＨ−Ｗ９１６、−Ｓ（Ｏ₂）ＮＷ９１７Ｗ９１８、−Ｓ（Ｏ₂）Ｏ−Ｗ９１９、−Ｐ（Ｏ）（ＯＷ９２０）（ＯＷ９２１）、−Ｓｉ（Ｗ９２２）（Ｗ９２３）（Ｗ９２４）"；
その際、Ｗ８７３、Ｗ８７４、Ｗ８７５、Ｗ８７６、Ｗ８７７、Ｗ８７８、Ｗ８７９、Ｗ８８０、Ｗ８８１、Ｗ８８２、Ｗ８８３、Ｗ８８４、Ｗ８８５、Ｗ８８６、Ｗ８８７、Ｗ８８８、Ｗ８８９、Ｗ８９０、Ｗ８９１、Ｗ８９２、Ｗ８９３、Ｗ８９４、Ｗ８９５、Ｗ８９６、Ｗ８９７、Ｗ８９８、Ｗ８９９、Ｗ９００、Ｗ９０１、Ｗ９０２、Ｗ９０３、Ｗ９０４、Ｗ９０５、Ｗ９０６、Ｗ９０７、Ｗ９０８、Ｗ９０９、Ｗ９１０、Ｗ９１１、Ｗ９１２、Ｗ９１３、Ｗ９１４、Ｗ９１５、Ｗ９１６、Ｗ９１７、Ｗ９１８、Ｗ９１９、Ｗ９２０、Ｗ９２１、Ｗ９２２、Ｗ９２３、Ｗ９２４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ８７９、Ｗ８８０及び／又はＷ８８８、Ｗ８８９及び／又はＷ９０１、Ｗ９０２及び／又はＷ９０８、Ｗ９０９及び／又はＷ９１７、Ｗ９１８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｇ）ＯＺ６、
その際、Ｚ６は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ９２５、−ＮＷ９２６Ｗ９２７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ９２８、−Ｃ（Ｏ）Ｏ−Ｗ９２９、−Ｃ（Ｏ）ＮＨ−Ｗ９３０、−Ｃ（Ｏ）ＮＷ９３１Ｗ９３２、−Ｏ−Ｗ９３３、−Ｏ（−Ｗ９３４−Ｏ）_g−Ｈ（ｇ＝１、２、３、４、５）、−Ｏ（−Ｗ９３５−Ｏ）_g−Ｗ９３６（ｇ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ９３７、−ＯＣ（Ｏ）−Ｏ−Ｗ９３８、−ＯＣ（Ｏ）−ＮＨＷ９３９、−Ｏ−Ｃ（Ｏ）−ＮＷ９４０Ｗ９４１、−ＯＰ（Ｏ）（ＯＷ９４２）（ＯＷ９４３）、−ＯＳｉ（Ｗ９４４）（Ｗ９４５）（Ｗ９４６）、−ＯＳ（Ｏ₂）−Ｗ９４７、−ＮＨＣ（Ｏ）−Ｗ９４８、−ＮＷ９４９Ｃ（Ｏ）−Ｗ９５０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ９５１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ９５２、−ＮＨ−Ｃ（Ｏ）−ＮＷ９５３Ｗ９５４、−ＮＷ９５５−Ｃ（Ｏ）−Ｏ−Ｗ９５６、−ＮＷ９５７−Ｃ（Ｏ）−ＮＨ−Ｗ９５８、−ＮＷ９５９−Ｃ（Ｏ）−ＮＷ９６０Ｗ９６１、−ＮＨＳ（Ｏ₂）−Ｗ９６２、−ＮＷ９６３Ｓ（Ｏ₂）−Ｗ９６４、−Ｓ−Ｗ９６５、−Ｓ（Ｏ）−Ｗ９６６、−Ｓ（Ｏ₂）−Ｗ９６７、−Ｓ（Ｏ₂）ＮＨ−Ｗ９６８、−Ｓ（Ｏ₂）ＮＷ９６９Ｗ９７０、−Ｓ（Ｏ₂）Ｏ−Ｗ９７１、−Ｐ（Ｏ）（ＯＷ９７２）（ＯＷ９７３）、−Ｓｉ（Ｗ９７４）（Ｗ９７５）（Ｗ９７６）"；
その際、Ｗ９２５、Ｗ９２６、Ｗ９２７、Ｗ９２８、Ｗ９２９、Ｗ９３０、Ｗ９３１、Ｗ９３２、Ｗ９３３、Ｗ９３４、Ｗ９３５、Ｗ９３６、Ｗ９３７、Ｗ９３８、Ｗ９３９、Ｗ９４０、Ｗ９４１、Ｗ９４２、Ｗ９４３、Ｗ９４４、Ｗ９４５、Ｗ９４６、Ｗ９４７、Ｗ９４８、Ｗ９４９、Ｗ９５０、Ｗ９５１、Ｗ９５２、Ｗ９５３、Ｗ９５４、Ｗ９５５、Ｗ９５６、Ｗ９５７、Ｗ９５８、Ｗ９５９、Ｗ９６０、Ｗ９６１、Ｗ９６２、Ｗ９６３、Ｗ９６４、Ｗ９６５、Ｗ９６６、Ｗ９６７、Ｗ９６８、Ｗ９６９、Ｗ９７０、Ｗ９７１、Ｗ９７２、Ｗ９７３、Ｗ９７４、Ｗ９７５、Ｗ９７６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ９３１、Ｗ９３２及び／又はＷ９４０、Ｗ９４１及び／又はＷ９５３、Ｗ９５４及び／又はＷ９６０、Ｗ９６１及び／又はＷ９６９、Ｗ９７０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ９７７、−ＮＷ９７８Ｗ９７９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ９８０、−Ｃ（Ｏ）Ｏ−Ｗ９８１、−Ｃ（Ｏ）ＮＨ−Ｗ９８２、−Ｃ（Ｏ）ＮＷ９８３Ｗ９８４、−Ｏ−Ｗ９８５、−Ｏ（−Ｗ９８６−Ｏ）_h−Ｈ（ｈ＝１、２、３、４、５）、−Ｏ（−Ｗ９８７−Ｏ）_h−Ｗ９８８（ｈ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ９８９、−ＯＣ（Ｏ）−Ｏ−Ｗ９９０、−ＯＣ（Ｏ）−ＮＨＷ９９１、−Ｏ−Ｃ（Ｏ）−ＮＷ９９２Ｗ９９３、−ＯＰ（Ｏ）（ＯＷ９９４）（ＯＷ９９５）、−ＯＳｉ（Ｗ９９６）（Ｗ９９７）（Ｗ９９８）、−ＯＳ（Ｏ₂）−Ｗ９９９、−ＮＨＣ（Ｏ）−Ｗ１０００、−ＮＷ１００１Ｃ（Ｏ）−Ｗ１００２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１００３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１００４、−ＮＨ−Ｃ（Ｏ）−ＮＷ１００５Ｗ１００６、−ＮＷ１００７−Ｃ（Ｏ）−Ｏ−Ｗ１００８、−ＮＷ１００９−Ｃ（Ｏ）−ＮＨ−Ｗ１０１０、−ＮＷ１０１１−Ｃ（Ｏ）−ＮＷ１０１２Ｗ１０１３、−ＮＨＳ（Ｏ₂）−Ｗ１０１４、−ＮＷ１０１５Ｓ（Ｏ₂）−Ｗ１０１６、−Ｓ−Ｗ１０１７、−Ｓ（Ｏ）−Ｗ１０１８、−Ｓ（Ｏ₂）−Ｗ１０１９、−Ｓ（Ｏ₂）ＮＨ−Ｗ１０２０、−Ｓ（Ｏ₂）ＮＷ１０２１Ｗ１０２２、−Ｓ（Ｏ₂）Ｏ−Ｗ１０２３、−Ｐ（Ｏ）（ＯＷ１０２４）（ＯＷ１０２５）、−Ｓｉ（Ｗ１０２６）（Ｗ１０２７）（Ｗ１０２８）"；
その際、Ｗ９７７、Ｗ９７８、Ｗ９７９、Ｗ９８０、Ｗ９８１、Ｗ９８２、Ｗ９８３、Ｗ９８４、Ｗ９８５、Ｗ９８６、Ｗ９８７、Ｗ９８８、Ｗ９８９、Ｗ９９０、Ｗ９９１、Ｗ９９２、Ｗ９９３、Ｗ９９４、Ｗ９９５、Ｗ９９６、Ｗ９９７、Ｗ９９８、Ｗ９９９、Ｗ１０００、Ｗ１００１、Ｗ１００２、Ｗ１００３、Ｗ１００４、Ｗ１００５、Ｗ１００６、Ｗ１００７、Ｗ１００８、Ｗ１００９、Ｗ１０１０、Ｗ１０１１、Ｗ１０１２、Ｗ１０１３、Ｗ１０１４、Ｗ１０１５、Ｗ１０１６、Ｗ１０１７、Ｗ１０１８、Ｗ１０１９、Ｗ１０２０、Ｗ１０２１、Ｗ１０２２、Ｗ１０２３、Ｗ１０２４、Ｗ１０２５、Ｗ１０２６、Ｗ１０２７、Ｗ１０２８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ９８３、Ｗ９８４及び／又はＷ９９２、Ｗ９９３及び／又はＷ１００５、Ｗ１００６及び／又はＷ１０１２、Ｗ１０１３及び／又はＷ１０２１、Ｗ１０２２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｈ）ＳＺ７、
その際、Ｚ７は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１０２９、−ＮＷ１０３０Ｗ１０３１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ１０３２、−Ｃ（Ｏ）Ｏ−Ｗ１０３３、−Ｃ（Ｏ）ＮＨ−Ｗ１０３４、−Ｃ（Ｏ）ＮＷ１０３５Ｗ１０３６、−Ｏ−Ｗ１０３７、−Ｏ（−Ｗ１０３８−Ｏ）_i−Ｈ（ｉ＝１、２、３、４、５）、−Ｏ（−Ｗ１０３９−Ｏ）_i−Ｗ１０４０（ｉ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１０４１、−ＯＣ（Ｏ）−Ｏ−Ｗ１０４２、−ＯＣ（Ｏ）−ＮＨＷ１０４３、−Ｏ−Ｃ（Ｏ）−ＮＷ１０４４Ｗ１０４５、−ＯＰ（Ｏ）（ＯＷ１０４６）（ＯＷ１０４７）、−ＯＳｉ（Ｗ１０４８）（Ｗ１０４９）（Ｗ１０５０）、−ＯＳ（Ｏ₂）−Ｗ１０５１、−ＮＨＣ（Ｏ）−Ｗ１０５２、−ＮＷ１０５３Ｃ（Ｏ）−Ｗ１０５４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１０５５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１０５６、−ＮＨ−Ｃ（Ｏ）−ＮＷ１０５７Ｗ１０５８、−ＮＷ１０５９−Ｃ（Ｏ）−Ｏ−Ｗ１０６０、−ＮＷ１０６１−Ｃ（Ｏ）−ＮＨ−Ｗ１０６２、−ＮＷ１０６３−Ｃ（Ｏ）−ＮＷ１０６４Ｗ１０６５、−ＮＨＳ（Ｏ₂）−Ｗ１０６６、−ＮＷ１０６７Ｓ（Ｏ₂）−Ｗ１０６８、−Ｓ−Ｗ１０６９、−Ｓ（Ｏ）−Ｗ１０７０、−Ｓ（Ｏ₂）−Ｗ１０７１、−Ｓ（Ｏ₂）ＮＨ−Ｗ１０７２、−Ｓ（Ｏ₂）ＮＷ１０７３Ｗ１０７４、−Ｓ（Ｏ₂）Ｏ−Ｗ１０７５、−Ｐ（Ｏ）（ＯＷ１０７６）（ＯＷ１０７７）、−Ｓｉ（Ｗ１０７８）（Ｗ１０７９）（Ｗ１０８０）"；
その際、Ｗ１０２９、Ｗ１０３０、Ｗ１０３１、Ｗ１０３２、Ｗ１０３３、Ｗ１０３４、Ｗ１０３５、Ｗ１０３６、Ｗ１０３７、Ｗ１０３８、Ｗ１０３９、Ｗ１０４０、Ｗ１０４１、Ｗ１０４２、Ｗ１０４３、Ｗ１０４４、Ｗ１０４５、Ｗ１０４６、Ｗ１０４７、Ｗ１０４８、Ｗ１０４９、Ｗ１０５０、Ｗ１０５１、Ｗ１０５２、Ｗ１０５３、Ｗ１０５４、Ｗ１０５５、Ｗ１０５６、Ｗ１０５７、Ｗ１０５８、Ｗ１０５９、Ｗ１０６０、Ｗ１０６１、Ｗ１０６２、Ｗ１０６３、Ｗ１０６４、Ｗ１０６５、Ｗ１０６６、Ｗ１０６７、Ｗ１０６８、Ｗ１０６９、Ｗ１０７０、Ｗ１０７１、Ｗ１０７２、Ｗ１０７３、Ｗ１０７４、Ｗ１０７５、Ｗ１０７６、Ｗ１０７７、Ｗ１０７８、Ｗ１０７９、Ｗ１０８０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ１０３５、Ｗ１０３６及び／又はＷ１０４４、Ｗ１０４５及び／又はＷ１０５７、Ｗ１０５８及び／又はＷ１０６４、Ｗ１０６５及び／又はＷ１０７３、Ｗ１０７４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１０８１、−ＮＷ１０８２Ｗ１０８３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ１０８４、−Ｃ（Ｏ）Ｏ−Ｗ１０８５、−Ｃ（Ｏ）ＮＨ−Ｗ１０８６、−Ｃ（Ｏ）ＮＷ１０８７Ｗ１０８８、−Ｏ−Ｗ１０８９、−Ｏ（−Ｗ１０９０−Ｏ）_j−Ｈ（ｊ＝１、２、３、４、５）、−Ｏ（−Ｗ１０９１−Ｏ）_j−Ｗ１０９２（ｊ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１０９３、−ＯＣ（Ｏ）−Ｏ−Ｗ１０９４、−ＯＣ（Ｏ）−ＮＨＷ１０９５、−Ｏ−Ｃ（Ｏ）−ＮＷ１０９６Ｗ１０９７、−ＯＰ（Ｏ）（ＯＷ１０９８）（ＯＷ１０９９）、−ＯＳｉ（Ｗ１１００）（Ｗ１１０１）（Ｗ１１０２）、−ＯＳ（Ｏ₂）−Ｗ１１０３、−ＮＨＣ（Ｏ）−Ｗ１１０４、−ＮＷ１１０５Ｃ（Ｏ）−Ｗ１１０６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１１０７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１１０８、−ＮＨ−Ｃ（Ｏ）−ＮＷ１１０９Ｗ１１１０、−ＮＷ１１１１−Ｃ（Ｏ）−Ｏ−Ｗ１１１２、−ＮＷ１１１３−Ｃ（Ｏ）−ＮＨ−Ｗ１１１４、−ＮＷ１１１５−Ｃ（Ｏ）−ＮＷ１１１６Ｗ１１１７、−ＮＨＳ（Ｏ₂）−Ｗ１１１８、−ＮＷ１１１９Ｓ（Ｏ₂）−Ｗ１１２０、−Ｓ−Ｗ１１２１、−Ｓ（Ｏ）−Ｗ１１２２、−Ｓ（Ｏ₂）−Ｗ１１２３、−Ｓ（Ｏ₂）ＮＨ−Ｗ１１２４、−Ｓ（Ｏ₂）ＮＷ１１２５Ｗ１１２６、−Ｓ（Ｏ₂）Ｏ−Ｗ１１２７、−Ｐ（Ｏ）（ＯＷ１１２８）（ＯＷ１１２９）、−Ｓｉ（Ｗ１１３０）（Ｗ１１３１）（Ｗ１１３２）"；
その際、Ｗ１０８１、Ｗ１０８２、Ｗ１０８３、Ｗ１０８４、Ｗ１０８５、Ｗ１０８６、Ｗ１０８７、Ｗ１０８８、Ｗ１０８９、Ｗ１０９０、Ｗ１０９１、Ｗ１０９２、Ｗ１０９３、Ｗ１０９４、Ｗ１０９５、Ｗ１０９６、Ｗ１０９７、Ｗ１０９８、Ｗ１０９９、Ｗ１１００、Ｗ１１０１、Ｗ１１０２、Ｗ１１０３、Ｗ１１０４、Ｗ１１０５、Ｗ１１０６、Ｗ１１０７、Ｗ１１０８、Ｗ１１０９、Ｗ１１１０、Ｗ１１１１、Ｗ１１１２、Ｗ１１１３、Ｗ１１１４、Ｗ１１１５、Ｗ１１１６、Ｗ１１１７、Ｗ１１１８、Ｗ１１１９、Ｗ１１２０、Ｗ１１２１、Ｗ１１２２、Ｗ１１２３、Ｗ１１２４、Ｗ１１２５、Ｗ１１２６、Ｗ１１２７、Ｗ１１２８、Ｗ１１２９、Ｗ１１３０、Ｗ１１３１、Ｗ１１３２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ１０８７、Ｗ１０８８及び／又はＷ１０９６、Ｗ１０９７及び／又はＷ１１０９、Ｗ１１１０及び／又はＷ１１１６、Ｗ１１１７及び／又はＷ１１２５、Ｗ１１２６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｊ）ＮＺ８Ｚ９、
その際、Ｚ８、Ｚ９は、互いに無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−Ｗ１１３３、−Ｃ（Ｏ）Ｏ−Ｗ１１３４、−Ｃ（Ｏ）−ＮＷ１１３５Ｗ１１３６、−Ｓ（Ｏ₂）−Ｗ１１３７、−Ｓ（Ｏ₂）Ｏ−Ｗ１１３８"；
その際、Ｗ１１３３、Ｗ１１３４、Ｗ１１３５、Ｗ１１３６、Ｗ１１３７、Ｗ１１３８は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｗ１１３５、Ｗ１１３６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１１３９、−ＮＷ１１４０Ｗ１１４１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ１１４２、−Ｃ（Ｏ）Ｏ−Ｗ１１４３、−Ｃ（Ｏ）ＮＨ−Ｗ１１４４、−Ｃ（Ｏ）ＮＷ１１４５Ｗ１１４６、−Ｏ−Ｗ１１４７、−Ｏ（−Ｗ１１４８−Ｏ）_k−Ｈ（ｋ＝１、２、３、４、５）、−Ｏ（−Ｗ１１４９−Ｏ）_k−Ｗ１１５０（ｋ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１１５１、−ＯＣ（Ｏ）−Ｏ−Ｗ１１５２、−ＯＣ（Ｏ）−ＮＨＷ１１５３、−Ｏ−Ｃ（Ｏ）−ＮＷ１１５４Ｗ１１５５、−ＯＰ（Ｏ）（ＯＷ１１５６）（ＯＷ１１５７）、−ＯＳｉ（Ｗ１１５８）（Ｗ１１５９）（Ｗ１１６０）、−ＯＳ（Ｏ₂）−Ｗ１１６１、−ＮＨＣ（Ｏ）−Ｗ１１６２、−ＮＷ１１６３Ｃ（Ｏ）−Ｗ１１６４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１１６５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１１６６、−ＮＨ−Ｃ（Ｏ）−ＮＷ１１６７Ｗ１１６８、−ＮＷ１１６９−Ｃ（Ｏ）−Ｏ−Ｗ１１７０、−ＮＷ１１７１−Ｃ（Ｏ）−ＮＨ−Ｗ１１７２、−ＮＷ１１７３−Ｃ（Ｏ）−ＮＷ１１７４Ｗ１１７５、−ＮＨＳ（Ｏ₂）−Ｗ１１７６、−ＮＷ１１７７Ｓ（Ｏ₂）−Ｗ１１７８、−Ｓ−Ｗ１１７９、−Ｓ（Ｏ）−Ｗ１１８０、−Ｓ（Ｏ₂）−Ｗ１１８１、−Ｓ（Ｏ₂）ＮＨ−Ｗ１１８２、−Ｓ（Ｏ₂）ＮＷ１１８３Ｗ１１８４、−Ｓ（Ｏ₂）Ｏ−Ｗ１１８５、−Ｐ（Ｏ）（ＯＷ１１８６）（ＯＷ１１８７）、−Ｓｉ（Ｗ１１８８）（Ｗ１１８９）（Ｗ１１９０）"；
その際、Ｗ１１３９、Ｗ１１４０、Ｗ１１４１、Ｗ１１４２、Ｗ１１４３、Ｗ１１４４、Ｗ１１４５、Ｗ１１４６、Ｗ１１４７、Ｗ１１４８、Ｗ１１４９、Ｗ１１５０、Ｗ１１５１、Ｗ１１５２、Ｗ１１５３、Ｗ１１５４、Ｗ１１５５、Ｗ１１５６、Ｗ１１５７、Ｗ１１５８、Ｗ１１５９、Ｗ１１６０、Ｗ１１６１、Ｗ１１６２、Ｗ１１６３、Ｗ１１６４、Ｗ１１６５、Ｗ１１６６、Ｗ１１６７、Ｗ１１６８、Ｗ１１６９、Ｗ１１７０、Ｗ１１７１、Ｗ１１７２、Ｗ１１７３、Ｗ１１７４、Ｗ１１７５、Ｗ１１７６、Ｗ１１７７、Ｗ１１７８、Ｗ１１７９、Ｗ１１８０、Ｗ１１８１、Ｗ１１８２、Ｗ１１８３、Ｗ１１８４、Ｗ１１８５、Ｗ１１８６、Ｗ１１８７、Ｗ１１８８、Ｗ１１８９、Ｗ１１９０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ１１４５、Ｗ１１４６及び／又はＷ１１５４、Ｗ１１５５及び／又はＷ１１６７、Ｗ１１６８及び／又はＷ１１７４、Ｗ１１７５及び／又はＷ１１８３、Ｗ１１８４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＷ１１９１、−ＮＷ１１９２Ｗ１１９３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｗ１１９４、−Ｃ（Ｏ）Ｏ−Ｗ１１９５、−Ｃ（Ｏ）ＮＨ−Ｗ１１９６、−Ｃ（Ｏ）ＮＷ１１９７Ｗ１１９８、−Ｏ−Ｗ１１９９、−Ｏ（−Ｗ１２００−Ｏ）_l−Ｈ（ｌ＝１、２、３、４、５）、−Ｏ（−Ｗ１２０１−Ｏ）_l−Ｗ１２０２（ｌ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｗ１２０３、−ＯＣ（Ｏ）−Ｏ−Ｗ１２０４、−ＯＣ（Ｏ）−ＮＨＷ１２０５、−Ｏ−Ｃ（Ｏ）−ＮＷ１２０６Ｗ１２０７、−ＯＰ（Ｏ）（ＯＷ１２０８）（ＯＷ１２０９）、−ＯＳｉ（Ｗ１２１０）（Ｗ１２１１）（Ｗ１２１２）、−ＯＳ（Ｏ₂）−Ｗ１２１３、−ＮＨＣ（Ｏ）−Ｗ１２１４、−ＮＷ１２１５Ｃ（Ｏ）−Ｗ１２１６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｗ１２１７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｗ１２１８、−ＮＨ−Ｃ（Ｏ）−ＮＷ１２１９Ｗ１２２０、−ＮＷ１２２１−Ｃ（Ｏ）−Ｏ−Ｗ１２２２、−ＮＷ１２２３−Ｃ（Ｏ）−ＮＨ−Ｗ１２２４、−ＮＷ１２２５−Ｃ（Ｏ）−ＮＷ１２２６Ｗ１２２７、−ＮＨＳ（Ｏ₂）−Ｗ１２２８、−ＮＷ１２２９Ｓ（Ｏ₂）−Ｗ１２３０、−Ｓ−Ｗ１２３１、−Ｓ（Ｏ）−Ｗ１２３２、−Ｓ（Ｏ₂）−Ｗ１２３３、−Ｓ（Ｏ₂）ＮＨ−Ｗ１２３４、−Ｓ（Ｏ₂）ＮＷ１２３５Ｗ１２３６、−Ｓ（Ｏ₂）Ｏ−Ｗ１２３７、−Ｐ（Ｏ）（ＯＷ１２３８）（ＯＷ１２３９）、−Ｓｉ（Ｗ１２４０）（Ｗ１２４１）（Ｗ１２４２）"；
その際、Ｗ１１９１、Ｗ１１９２、Ｗ１１９３、Ｗ１１９４、Ｗ１１９５、Ｗ１１９６、Ｗ１１９７、Ｗ１１９８、Ｗ１１９９、Ｗ１２００、Ｗ１２０１、Ｗ１２０２、Ｗ１２０３、Ｗ１２０４、Ｗ１２０５、Ｗ１２０６、Ｗ１２０７、Ｗ１２０８、Ｗ１２０９、Ｗ１２１０、Ｗ１２１１、Ｗ１２１２、Ｗ１２１３、Ｗ１２１４、Ｗ１２１５、Ｗ１２１６、Ｗ１２１７、Ｗ１２１８、Ｗ１２１９、Ｗ１２２０、Ｗ１２２１、Ｗ１２２２、Ｗ１２２３、Ｗ１２２４、Ｗ１２２５、Ｗ１２２６、Ｗ１２２７、Ｗ１２２８、Ｗ１２２９、Ｗ１２３０、Ｗ１２３１、Ｗ１２３２、Ｗ１２３３、Ｗ１２３４、Ｗ１２３５、Ｗ１２３６、Ｗ１２３７、Ｗ１２３８、Ｗ１２３９、Ｗ１２４０、Ｗ１２４１、Ｗ１２４２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＷ１１９７、Ｗ１１９８及び／又はＷ１２０６、Ｗ１２０７及び／又はＷ１２１９、Ｗ１２２０及び／又はＷ１２２６、Ｗ１２２７及び／又はＷ１２３５、Ｗ１２３６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
又は、
（Ｄ）
基Ｚ３、Ｚ４の一方もしくは両方の基Ｚ３、Ｚ４は、互いに無関係に、以下のものからなる群から選択される：
（１）"−ＮＺ１０Ｚ１１、−ＯＺ１２、−ＳＺ１３"；
その際、基Ｚ１０、Ｚ１１の一方もしくは両方の基Ｚ１０、Ｚ１１及び基Ｚ１２、Ｚ１３は、互いに無関係に、以下のものからなる群から選択される：
（ａ）"水素、アルキル、シクロアルキル、シクロアルキルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、ヘテロシクリル、ヘテロシクリルアルキル"；
但し、両方の基Ｚ１０、Ｚ１１は、同時に水素ではない；
但し、更に、基Ｚ１２は、水素ではない；
但し、更に、置換基群（ａ）の前記置換基は、水素でない場合に、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されている：
（ｉ）"Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｎ₃、−ＮＨ−シクロアルキル、−ＮＨ−シクロアルキルアルキル、−ＮＨ−ヘテロアリール、−ＮＨ−ヘテロアリールアルキル、−ＮＨ−アリールアルキル、−ＮＨ−ヘテロシクリル、−ＮＨ−ヘテロシクリルアルキル、−ＮＱ１Ｑ２、−Ｓ−シクロアルキル、−Ｓ−シクロアルキルアルキル、−Ｓ−アリール、−Ｓ−アリールアルキル、−Ｓ−ヘテロアリール、−Ｓ−ヘテロアリールアルキル、−Ｓ−ヘテロシクリル、−Ｓ−ヘテロシクリルアルキル、−Ｏ−シクロアルキル、−Ｏ−シクロアルキルアルキル、−Ｏ−アリールアルキル、−Ｏ−ヘテロアリール、−Ｏ−ヘテロアリールアルキル、−Ｏ−ヘテロシクリル、−Ｏ−ヘテロシクリルアルキル、−Ｏ（−Ｑ３−Ｏ）_p−Ｑ４（ｐ＝１、２、３、４、５）、−Ｏ（−Ｑ５−Ｏ）_p−Ｈ（ｐ＝１、２、３、４、５）、−ＯＰ（Ｏ）（ＯＱ６）（ＯＱ７）、−Ｃ（Ｏ）Ｏ−Ｑ８、−Ｃ（Ｏ）ＮＨ₂、−Ｃ（Ｏ）ＮＨ−Ｑ９、−Ｃ（Ｏ）ＮＱ１０Ｑ１１、−Ｓ（Ｏ₂）−Ｑ１２、−Ｐ（Ｏ）（ＯＨ）₂、−Ｐ（Ｏ）（ＯＱ１３）（ＯＱ１４）、−Ｓｉ（Ｑ１５）（Ｑ１６）（Ｑ１７）、−Ｏ−Ｓｉ（Ｑ１８）（Ｑ１９）（Ｑ２０）、−Ｏ−Ｃ（Ｏ）−Ｏ−Ｑ２１、−Ｏ−Ｃ（Ｏ）−ＮＨ−Ｑ２２、−Ｏ−Ｃ（Ｏ）−ＮＱ２３Ｑ２４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ２５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ２６、−ＮＨ−Ｃ（Ｏ）−ＮＱ２７Ｑ２８、−ＮＱ２９−Ｃ（Ｏ）−Ｏ−Ｑ３０、−ＮＱ３１−Ｃ（Ｏ）−ＮＨ−Ｑ３２、−ＮＱ３３−Ｃ（Ｏ）−ＮＱ３４Ｑ３５、−ＮＱ３６−Ｓ（Ｏ₂）−Ｑ３７、−ＮＨ−Ｓ（Ｏ₂）−Ｑ３８、−Ｏ−Ｓ（Ｏ₂）−Ｑ３９、−ＮＨ−Ｃ（Ｏ）−Ｑ４０、−ＮＱ４１−Ｃ（Ｏ）−Ｑ４２、−Ｃ（Ｏ）−Ｑ４３、−ＯＣ（Ｏ）−Ｑ４４、−Ｓ（Ｏ）−Ｑ４５、−Ｓ（Ｏ₂）−ＮＨＱ４６、−Ｓ（Ｏ₂）−ＮＱ４７Ｑ４８、−Ｓ（Ｏ₂）−ＯＱ４９"；
但し、更に、"−Ｎ（アルキル）₂"は、以下の置換基群（ｉｉ）から選択される少なくとも１つの置換基によって更に置換されている；
その際、Ｑ１、Ｑ２、Ｑ３、Ｑ４、Ｑ５、Ｑ６、Ｑ７、Ｑ８、Ｑ９、Ｑ１０、Ｑ１１、Ｑ１２、Ｑ１３、Ｑ１４、Ｑ１５、Ｑ１６、Ｑ１７、Ｑ１８、Ｑ１９、Ｑ２０、Ｑ２１、Ｑ２２、Ｑ２３、Ｑ２４、Ｑ２５、Ｑ２６、Ｑ２７、Ｑ２８、Ｑ２９、Ｑ３０、Ｑ３１、Ｑ３２、Ｑ３３、Ｑ３４、Ｑ３５、Ｑ３６、Ｑ３７、Ｑ３８、Ｑ３９、Ｑ４０、Ｑ４１、Ｑ４２、Ｑ４３、Ｑ４４、Ｑ４５、Ｑ４６、Ｑ４７、Ｑ４８、Ｑ４９は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｑ１０、Ｑ１１及び／又はＱ２３、Ｑ２４及び／又はＱ２７、Ｑ２８及び／又はＱ３４、Ｑ３５及び／又はＱ４７、Ｑ４８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ａ）及び／又は置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ５０、−ＮＱ５１Ｑ５２、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ５３、−Ｃ（Ｏ）Ｏ−Ｑ５４、−Ｃ（Ｏ）ＮＨ−Ｑ５５、−Ｃ（Ｏ）ＮＱ５６Ｑ５７、−Ｏ−Ｑ５８、−Ｏ（−Ｑ５９−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｑ６０−Ｏ）_r−Ｑ６１（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ６２、−ＯＣ（Ｏ）−Ｏ−Ｑ６３、−ＯＣ（Ｏ）−ＮＨＱ６４、−Ｏ−Ｃ（Ｏ）−ＮＱ６５Ｑ６６、−ＯＰ（Ｏ）（ＯＱ６７）（ＯＱ６８）、−ＯＳｉ（Ｑ６９）（Ｑ７０）（Ｑ７１）、−ＯＳ（Ｏ₂）−Ｑ７２、−ＮＨＣ（Ｏ）−Ｑ７３、−ＮＱ７４Ｃ（Ｏ）−Ｑ７５、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ７６、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ７７、−ＮＨ−Ｃ（Ｏ）−ＮＱ７８Ｑ７９、−ＮＱ８０−Ｃ（Ｏ）−Ｏ−Ｑ８１、−ＮＱ８２−Ｃ（Ｏ）−ＮＨ−Ｑ８３、−ＮＱ８４−Ｃ（Ｏ）−ＮＱ８５Ｑ８６、−ＮＨＳ（Ｏ₂）−Ｑ８７、−ＮＱ８８Ｓ（Ｏ₂）−Ｑ８９、−Ｓ−Ｑ９０、−Ｓ（Ｏ）−Ｑ９１、−Ｓ（Ｏ₂）−Ｑ９２、−Ｓ（Ｏ₂）ＮＨ−Ｑ９３、−Ｓ（Ｏ₂）ＮＱ９４Ｑ９５、−Ｓ（Ｏ₂）Ｏ−Ｑ９６、−Ｐ（Ｏ）（ＯＱ９７）（ＯＱ９８）、−Ｓｉ（Ｑ９９）（Ｑ１００）（Ｑ１０１）"；
その際、Ｑ５０、Ｑ５２、Ｑ５３、Ｑ５４、Ｑ５５、Ｑ５６、Ｑ５７、Ｑ５８、Ｑ５９、Ｑ６０、Ｑ６１、Ｑ６２、Ｑ６３、Ｑ６４、Ｑ６５、Ｑ６６、Ｑ６７、Ｑ６８、Ｑ６９、Ｑ７０、Ｑ７１、Ｑ７２、Ｑ７３、Ｑ７４、Ｑ７５、Ｑ７６、Ｑ７７、Ｑ７８、Ｑ７９、Ｑ８０、Ｑ８１、Ｑ８２、Ｑ８３、Ｑ８４、Ｑ８５、Ｑ８６、Ｑ８７、Ｑ８８、Ｑ８９、Ｑ９０、Ｑ９１、Ｑ９２、Ｑ９３、Ｑ９４、Ｑ９５、Ｑ９６、Ｑ９７、Ｑ９８、Ｑ９９、Ｑ１００、Ｑ１０１は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ５６、Ｑ５７及び／又はＱ６５、Ｑ６６及び／又はＱ７８、Ｑ７９及び／又はＱ８５、Ｑ８６及び／又はＱ９４、Ｑ９５は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ１０２、−ＮＱ１０３Ｑ１０４、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ１０５、−Ｃ（Ｏ）Ｏ−Ｑ１０６、−Ｃ（Ｏ）ＮＨ−Ｑ１０７、−Ｃ（Ｏ）ＮＱ１０８Ｑ１０９、−Ｏ−Ｑ１１０、−Ｏ（−Ｑ１１１−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ｑ１１２−Ｏ）_s−Ｑ１１３（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ１１４、−ＯＣ（Ｏ）−Ｏ−Ｑ１１５、−ＯＣ（Ｏ）−ＮＨＱ１１６、−Ｏ−Ｃ（Ｏ）−ＮＱ１１７Ｑ１１８、−ＯＰ（Ｏ）（ＯＱ１１９）（ＯＱ１２０）、−ＯＳｉ（Ｑ１２１）（Ｑ１２２）（Ｑ１２３）、−ＯＳ（Ｏ₂）−Ｑ１２４、−ＮＨＣ（Ｏ）−Ｑ１２５、−ＮＱ１２６Ｃ（Ｏ）−Ｑ１２７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１２８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１２９、−ＮＨ−Ｃ（Ｏ）−ＮＱ１３０Ｑ１３１、−ＮＱ１３２−Ｃ（Ｏ）−Ｏ−Ｑ１３３、−ＮＱ１３４−Ｃ（Ｏ）−ＮＨ−Ｑ１３５、−ＮＱ１３６−Ｃ（Ｏ）−ＮＱ１３７Ｑ１３８、−ＮＨＳ（Ｏ₂）−Ｑ１３９、−ＮＱ１４０Ｓ（Ｏ₂）−Ｑ１４１、−Ｓ−Ｑ１４２、−Ｓ（Ｏ）−Ｑ１４３、−Ｓ（Ｏ₂）−Ｑ１４４、−Ｓ（Ｏ₂）ＮＨ−Ｑ１４５、−Ｓ（Ｏ₂）ＮＱ１４６Ｑ１４７、−Ｓ（Ｏ₂）Ｏ−Ｑ１４８、−Ｐ（Ｏ）（ＯＱ１４９）（ＯＱ１５０）、−Ｓｉ（Ｑ１５２）（Ｑ１５２）（Ｑ１５３）"；
その際、Ｑ１０２、Ｑ１０３、Ｑ１０４、Ｑ１０５、Ｑ１０６、Ｑ１０７、Ｑ１０８、Ｑ１０９、Ｑ１１０、Ｑ１１１、Ｑ１１２、Ｑ１１３、Ｑ１１４、Ｑ１１５、Ｑ１１６、Ｑ１１７、Ｑ１１８、Ｑ１１９、Ｑ１２０、Ｑ１２１、Ｑ１２２、Ｑ１２３、Ｑ１２４、Ｑ１２５、Ｑ１２６、Ｑ１２７、Ｑ１２８、Ｑ１２９、Ｑ１３０、Ｑ１３１、Ｑ１３２、Ｑ１３３、Ｑ１３４、Ｑ１３５、Ｑ１３６、Ｑ１３７、Ｑ１３８、Ｑ１３９、Ｑ１４０、Ｑ１４１、Ｑ１４２、Ｑ１４３、Ｑ１４４、Ｑ１４５、Ｑ１４６、Ｑ１４７、Ｑ１４８、Ｑ１４９、Ｑ１５０、Ｑ１５１、Ｑ１５２、Ｑ１５３は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ１０８、Ｑ１０９及び／又はＱ１１７、Ｑ１１８及び／又はＱ１３０、Ｑ１３１及び／又はＱ１３７、Ｑ１３８及び／又はＱ１４６、Ｑ１４７は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｂ）"Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−Ｑ１５４、−Ｃ（Ｏ）Ｏ−Ｑ１５５、−Ｃ（Ｏ）−ＮＱ１５６Ｑ１５７、−Ｓ（Ｏ₂）−Ｑ１５８、−Ｓ（Ｏ₂）Ｏ−Ｑ１５９"；
その際、Ｑ１５４、Ｑ１５５、Ｑ１５６、Ｑ１５７、Ｑ１５８、Ｑ１５９は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｑ１５６、Ｑ１５７は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｂ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ１６０、−ＮＱ１６１Ｑ１６２、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ１６３、−Ｃ（Ｏ）Ｏ−Ｑ１６４、−Ｃ（Ｏ）ＮＨ−Ｑ１６５、−Ｃ（Ｏ）ＮＱ１６６Ｑ１６７、−Ｏ−Ｑ１６８、−Ｏ（−Ｑ１６９−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｑ１７０−Ｏ）_t−Ｑ１７１（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ１７２、−ＯＣ（Ｏ）−Ｏ−Ｑ１７３、−ＯＣ（Ｏ）−ＮＨＱ１７４、−Ｏ−Ｃ（Ｏ）−ＮＱ１７５Ｑ１７６、−ＯＰ（Ｏ）（ＯＱ１７７）（ＯＱ１７８）、−ＯＳｉ（Ｑ１７９）（Ｑ１８０）（Ｑ１８１）、−ＯＳ（Ｏ₂）−Ｑ１８２、−ＮＨＣ（Ｏ）−Ｑ１８３、−ＮＱ１８４Ｃ（Ｏ）−Ｑ１８５、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１８６、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１８７、−ＮＨ−Ｃ（Ｏ）−ＮＱ１８８Ｑ１８９、−ＮＱ１９０−Ｃ（Ｏ）−Ｏ−Ｑ１９１、−ＮＱ１９２−Ｃ（Ｏ）−ＮＨ−Ｑ１９３、−ＮＱ１９４−Ｃ（Ｏ）−ＮＱ１９５Ｑ１９６、−ＮＨＳ（Ｏ₂）−Ｑ１９７、−ＮＱ１９８Ｓ（Ｏ₂）−Ｑ１９９、−Ｓ−Ｑ２００、−Ｓ（Ｏ）−Ｑ２０１、−Ｓ（Ｏ₂）−Ｑ２０２、−Ｓ（Ｏ₂）ＮＨ−Ｑ２０３、−Ｓ（Ｏ₂）ＮＱ２０４Ｑ２０５、−Ｓ（Ｏ₂）Ｏ−Ｑ２０６、−Ｐ（Ｏ）（ＯＱ２０７）（ＯＱ２０８）、−Ｓｉ（Ｑ２０９）（Ｑ２１０）（Ｑ２１１）"；
その際、Ｑ１６０、Ｑ１６１、Ｑ１６２、Ｑ１６３、Ｑ１６４、Ｑ１６５、Ｑ１６６、Ｑ１６７、Ｑ１６８、Ｑ１６９、Ｑ１７０、Ｑ１７１、Ｑ１７２、Ｑ１７３、Ｑ１７４、Ｑ１７５、Ｑ１７６、Ｑ１７７、Ｑ１７８、Ｑ１７９、Ｑ１８０、Ｑ１８１、Ｑ１８２、Ｑ１８３、Ｑ１８４、Ｑ１８５、Ｑ１８６、Ｑ１８７、Ｑ１８８、Ｑ１８９、Ｑ１９０、Ｑ１９１、Ｑ１９２、Ｑ１９３、Ｑ１９４、Ｑ１９５、Ｑ１９６、Ｑ１９７、Ｑ１９８、Ｑ１９９、Ｑ２００、Ｑ２０１、Ｑ２０２、Ｑ２０３、Ｑ２０４、Ｑ２０５、Ｑ２０６、Ｑ２０７、Ｑ２０８、Ｑ２０９、Ｑ２１０、Ｑ２１１は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ１６６、Ｑ１６７及び／又はＱ１７５、Ｑ１７６及び／又はＱ１８８、Ｑ１８９及び／又はＱ１９５、Ｑ１９６及び／又はＱ２０４、Ｑ２０５は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記の置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ２１２、−ＮＱ２１３Ｑ２１４、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ２１５、−Ｃ（Ｏ）Ｏ−Ｑ２１６、−Ｃ（Ｏ）ＮＨ−Ｑ２１７、−Ｃ（Ｏ）ＮＱ２１８Ｑ２１９、−Ｏ−Ｑ２２０、−Ｏ（−Ｑ２２１−Ｏ）_u−Ｈ（ｕ＝１、２、３、４、５）、−Ｏ（−Ｑ２２２−Ｏ）_u−Ｑ２２３（ｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ２２４、−ＯＣ（Ｏ）−Ｏ−Ｑ２２５、−ＯＣ（Ｏ）−ＮＨＱ２２６、−Ｏ−Ｃ（Ｏ）−ＮＱ２２７Ｑ２２８、−ＯＰ（Ｏ）（ＯＱ２２９）（ＯＱ２３０）、−ＯＳｉ（Ｑ２３１）（Ｑ２３２）（Ｑ２３３）、−ＯＳ（Ｏ₂）−Ｑ２３４、−ＮＨＣ（Ｏ）−Ｑ２３５、−ＮＱ２３６Ｃ（Ｏ）−Ｑ２３７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ２３８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ２３９、−ＮＨ−Ｃ（Ｏ）−ＮＱ２４０Ｑ２４１、−ＮＱ２４２−Ｃ（Ｏ）−Ｏ−Ｑ２４３、−ＮＱ２４４−Ｃ（Ｏ）−ＮＨ−Ｑ２４５、−ＮＱ２４６−Ｃ（Ｏ）−ＮＱ２４７Ｑ２４８、−ＮＨＳ（Ｏ₂）−Ｑ２４９、−ＮＱ２５０Ｓ（Ｏ₂）−Ｑ２５１、−Ｓ−Ｑ２５２、−Ｓ（Ｏ）−Ｑ２５３、−Ｓ（Ｏ₂）−Ｑ２５４、−Ｓ（Ｏ₂）ＮＨ−Ｑ２５５、−Ｓ（Ｏ₂）ＮＱ２５６Ｑ２５７、−Ｓ（Ｏ₂）Ｏ−Ｑ２５８、−Ｐ（Ｏ）（ＯＱ２５９）（ＯＱ２６０）、−Ｓｉ（Ｑ２６１）（Ｑ２６２）（Ｑ２６３）"；
その際、Ｑ２１２、Ｑ２１３、Ｑ２１４、Ｑ２１５、Ｑ２１６、Ｑ２１７、Ｑ２１８、Ｑ２１９、Ｑ２２０、Ｑ２２１、Ｑ２２２、Ｑ２２３、Ｑ２２４、Ｑ２２５、Ｑ２２６、Ｑ２２７、Ｑ２２８、Ｑ２２９、Ｑ２３０、Ｑ２３１、Ｑ２３２、Ｑ２３３、Ｑ２３４、Ｑ２３５、Ｑ２３６、Ｑ２３７、Ｑ２３８、Ｑ２３９、Ｑ２４０、Ｑ２４１、Ｑ２４２、Ｑ２４３、Ｑ２４４、Ｑ２４５、Ｑ２４６、Ｑ２４７、Ｑ２４８、Ｑ２４９、Ｑ２５０、Ｑ２５１、Ｑ２５２、Ｑ２５３、Ｑ２５４、Ｑ２５５、Ｑ２５６、Ｑ２５７、Ｑ２５８、Ｑ２５９、Ｑ２６０、Ｑ２６１、Ｑ２６２、Ｑ２６３は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｑ２１８、Ｑ２１９及び／又はＱ２２７、Ｑ２２８及び／又はＱ２４０、Ｑ２４１及び／又はＱ２４７、Ｑ２４８及び／又はＱ２５６、Ｑ２５７は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ２６４、−ＮＱ２６５Ｑ２６６、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ２６７、−Ｃ（Ｏ）Ｏ−Ｑ２６８、−Ｃ（Ｏ）ＮＨ−Ｑ２６９、−Ｃ（Ｏ）ＮＱ２７０Ｑ２７１、−Ｏ−Ｑ２７２、−Ｏ（−Ｑ２７３−Ｏ）_v−Ｈ（ｖ＝１、２、３、４、５）、−Ｏ（−Ｑ２７４−Ｏ）_v−Ｑ２７５（ｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ２７６、−ＯＣ（Ｏ）−Ｏ−Ｑ２７７、−ＯＣ（Ｏ）−ＮＨＱ２７８、−Ｏ−Ｃ（Ｏ）−ＮＱ２７９Ｑ２８０、−ＯＰ（Ｏ）（ＯＱ２８１）（ＯＱ２８２）、−ＯＳｉ（Ｑ２８３）（Ｑ２８４）（Ｑ２８５）、−ＯＳ（Ｏ₂）−Ｑ２８６、−ＮＨＣ（Ｏ）−Ｑ２８７、−ＮＱ２８８Ｃ（Ｏ）−Ｑ２８９、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ２９０、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ２９１、−ＮＨ−Ｃ（Ｏ）−ＮＱ２９２Ｑ２９３、−ＮＱ２９４−Ｃ（Ｏ）−Ｏ−Ｑ２９５、−ＮＱ２９６−Ｃ（Ｏ）−ＮＨ−Ｑ２９７、−ＮＱ２９８−Ｃ（Ｏ）−ＮＱ２９９Ｑ３００、−ＮＨＳ（Ｏ₂）−Ｑ３０１、−ＮＱ３０２Ｓ（Ｏ₂）−Ｑ３０３、−Ｓ−Ｑ３０４、−Ｓ（Ｏ）−Ｑ３０５、−Ｓ（Ｏ₂）−Ｑ３０６、−Ｓ（Ｏ₂）ＮＨ−Ｑ３０７、−Ｓ（Ｏ₂）ＮＱ３０８Ｑ３０９、−Ｓ（Ｏ₂）Ｏ−Ｑ３１０、−Ｐ（Ｏ）（ＯＱ３１１）（ＯＱ３１２）、−Ｓｉ（Ｑ３１３）（Ｑ３１４）（Ｑ３１５）"；
その際、Ｑ２６４、Ｑ２６５、Ｑ２６６、Ｑ２６７、Ｑ２６８、Ｑ２６９、Ｑ２７０、Ｑ２７１、Ｑ２７２、Ｑ２７３、Ｑ２７４、Ｑ２７５、Ｑ２７６、Ｑ２７７、Ｑ２７８、Ｑ２７９、Ｑ２８０、Ｑ２８１、Ｑ２８２、Ｑ２８３、Ｑ２８４、Ｑ２８５、Ｑ２８６、Ｑ２８７、Ｑ２８８、Ｑ２８９、Ｑ２９０、Ｑ２９１、Ｑ２９２、Ｑ２９３、Ｑ２９４、Ｑ２９５、Ｑ２９６、Ｑ２９７、Ｑ２９８、Ｑ２９９、Ｑ３００、Ｑ３０１、Ｑ３０２、Ｑ３０３、Ｑ３０４、Ｑ３０５、Ｑ３０６、Ｑ３０７、Ｑ３０８、Ｑ３０９、Ｑ３１０、Ｑ３１１、Ｑ３１２、Ｑ３１３、Ｑ３１４、Ｑ３１５は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ２７０、Ｑ２７１及び／又はＱ２７９、Ｑ２８９及び／又はＱ２９２、Ｑ２９３及び／又はＱ２９９、Ｑ３００及び／又はＱ３０８、Ｑ３０９は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ１０、Ｚ１１の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ１０、Ｚ１１のどちらも、以下のものからなる群から選択されない：
（ｃ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、ヘテロシクリル、ヘテロシクリルアルキル、−Ｃ（Ｏ）−Ｑ３１６、−Ｃ（Ｏ）Ｏ−Ｑ３１７、−Ｃ（Ｏ）−ＮＱ３１８Ｑ３１９、−Ｓ（Ｏ₂）−Ｑ３２０、−Ｓ（Ｏ₂）Ｏ−Ｑ３２１"；
その際、Ｑ３１６、Ｑ３１７、Ｑ３１８、Ｑ３１９、Ｑ３２０、Ｑ３２１は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｑ３１８、Ｑ３１９は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｃ）の前記の置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ３２２、−ＮＱ３２３Ｑ３２４、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ３２５、−Ｃ（Ｏ）Ｏ−Ｑ３２６、−Ｃ（Ｏ）ＮＨ−Ｑ３２７、−Ｃ（Ｏ）ＮＱ３２８Ｑ３２９、−Ｏ−Ｑ３３０、−Ｏ（−Ｑ３３１−Ｏ）_w−Ｈ（ｗ＝１、２、３、４、５）、−Ｏ（−Ｑ３３２−Ｏ）_w−Ｑ３３３（ｗ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ３３４、−ＯＣ（Ｏ）−Ｏ−Ｑ３３５、−ＯＣ（Ｏ）−ＮＨＱ３３６、−Ｏ−Ｃ（Ｏ）−ＮＱ３３７Ｑ３３８、−ＯＰ（Ｏ）（ＯＱ３３９）（ＯＱ３４０）、−ＯＳｉ（Ｑ３４１）（Ｑ３４２）（Ｑ３４３）、−ＯＳ（Ｏ₂）−Ｑ３４４、−ＮＨＣ（Ｏ）−Ｑ３４５、−ＮＱ３４６Ｃ（Ｏ）−Ｑ３４７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ３４８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ３４９、−ＮＨ−Ｃ（Ｏ）−ＮＱ３５０Ｑ３５１、−ＮＱ３５２−Ｃ（Ｏ）−Ｏ−Ｑ３５３、−ＮＱ３５４−Ｃ（Ｏ）−ＮＨ−Ｑ３５５、−ＮＱ３５６−Ｃ（Ｏ）−ＮＱ３５７Ｑ３５８、−ＮＨＳ（Ｏ₂）−Ｑ３５９、−ＮＱ３６０Ｓ（Ｏ₂）−Ｑ３６１、−Ｓ−Ｑ３６２、−Ｓ（Ｏ）−Ｑ３６３、−Ｓ（Ｏ₂）−Ｑ３６４、−Ｓ（Ｏ₂）ＮＨ−Ｑ３６５、−Ｓ（Ｏ₂）ＮＱ３６６Ｑ３６７、−Ｓ（Ｏ₂）Ｏ−Ｑ３６８、−Ｐ（Ｏ）（ＯＱ３６９）（ＯＱ３７０）、−Ｓｉ（Ｑ３７１）（Ｑ３７２）（Ｑ３７３）"；
その際、Ｑ３２２、Ｑ３２３、Ｑ３２４、Ｑ３２５、Ｑ３２６、Ｑ３２７、Ｑ３２８、Ｑ３２９、Ｑ３３０、Ｑ３３１、Ｑ３３２、Ｑ３３３、Ｑ３３４、Ｑ３３５、Ｑ３３６、Ｑ３３７、Ｑ３３８、Ｑ３３９、Ｑ３４０、Ｑ３４１、Ｑ３４２、Ｑ３４３、Ｑ３４４、Ｑ３４５、Ｑ３４６、Ｑ３４７、Ｑ３４８、Ｑ３４９、Ｑ３５０、Ｑ３５１、Ｑ３５２、Ｑ３５３、Ｑ３５４、Ｑ３５５、Ｑ３５６、Ｑ３５７、Ｑ３５８、Ｑ３５９、Ｑ３６０、Ｑ３６１、Ｑ３６２、Ｑ３６３、Ｑ３６４、Ｑ３６５、Ｑ３６６、Ｑ３６７、Ｑ３６８、Ｑ３６９、Ｑ３７０、Ｑ３７１、Ｑ３７２、Ｑ３７３は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ３２８、Ｑ３２９及び／又はＱ３３７、Ｑ３３８及び／又はＱ３５０、Ｑ３５１及び／又はＱ３５７、Ｑ３５８及び／又はＱ３６６、Ｑ３６７は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい；
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ３７４、−ＮＱ３７５Ｑ３７６、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ３７７、−Ｃ（Ｏ）Ｏ−Ｑ３７８、−Ｃ（Ｏ）ＮＨ−Ｑ３７９、−Ｃ（Ｏ）ＮＱ３８０Ｑ３８１、−Ｏ−Ｑ３８２、−Ｏ（−Ｑ３８３−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−Ｏ（−Ｑ３８４−Ｏ）_x−Ｑ３８５（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ３８６、−ＯＣ（Ｏ）−Ｏ−Ｑ３８７、−ＯＣ（Ｏ）−ＮＨＱ３８８、−Ｏ−Ｃ（Ｏ）−ＮＱ３８９Ｑ３９０、−ＯＰ（Ｏ）（ＯＱ３９１）（ＯＱ３９２）、−ＯＳｉ（Ｑ３９３）（Ｑ３９４）（Ｑ３９５）、−ＯＳ（Ｏ₂）−Ｑ３９６、−ＮＨＣ（Ｏ）−Ｑ３９７、−ＮＱ３９８Ｃ（Ｏ）−Ｑ３９９、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ４００、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ４０１、−ＮＨ−Ｃ（Ｏ）−ＮＱ４０２Ｑ４０３、−ＮＱ４０４−Ｃ（Ｏ）−Ｏ−Ｑ４０５、−ＮＱ４０６−Ｃ（Ｏ）−ＮＨ−Ｑ４０７、−ＮＱ４０８−Ｃ（Ｏ）−ＮＱ４０９Ｑ４１０、−ＮＨＳ（Ｏ₂）−Ｑ４１１、−ＮＱ４１２Ｓ（Ｏ₂）−Ｑ４１３、−Ｓ−Ｑ４１４、−Ｓ（Ｏ）−Ｑ４１５、−Ｓ（Ｏ₂）−Ｑ４１６、−Ｓ（Ｏ₂）ＮＨ−Ｑ４１７、−Ｓ（Ｏ₂）ＮＱ４１８Ｑ４１９、−Ｓ（Ｏ₂）Ｏ−Ｑ４２０、−Ｐ（Ｏ）（ＯＱ４２１）（ＯＱ４２２）、−Ｓｉ（Ｑ４２３）（Ｑ４２４）（Ｑ４２５）"；
その際、Ｑ３７４、Ｑ３７５、Ｑ３７６、Ｑ３７７、Ｑ３７８、Ｑ３７９、Ｑ３８０、Ｑ３８１、Ｑ３８２、Ｑ３８３、Ｑ３８４、Ｑ３８５、Ｑ３８６、Ｑ３８７、Ｑ３８８、Ｑ３８９、Ｑ３９０、Ｑ３９１、Ｑ３９２、Ｑ３９３、Ｑ３９４、Ｑ３９５、Ｑ３９６、Ｑ３９７、Ｑ３９８、Ｑ３９９、Ｑ４００、Ｑ４０１、Ｑ４０２、Ｑ４０３、Ｑ４０４、Ｑ４０５、Ｑ４０６、Ｑ４０７、Ｑ４０８、Ｑ４０９、Ｑ４１０、Ｑ４１１、Ｑ４１２、Ｑ４１３、Ｑ４１４、Ｑ４１５、Ｑ４１６、Ｑ４１７、Ｑ４１８、Ｑ４１９、Ｑ４２０、Ｑ４２１、Ｑ４２２、Ｑ４２３、Ｑ４２４、Ｑ４２５は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ３８０、Ｑ３８１及び／又はＱ３８９、Ｑ３９０及び／又はＱ４０２、Ｑ４０３及び／又はＱ４０９、Ｑ４１０及び／又はＱ４１８、Ｑ４１９は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ４２６、−ＮＱ４２７Ｑ４２８、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ４２９、−Ｃ（Ｏ）Ｏ−Ｑ４３０、−Ｃ（Ｏ）ＮＨ−Ｑ４３１、−Ｃ（Ｏ）ＮＱ４３２Ｑ４３３、−Ｏ−Ｑ４３４、−Ｏ（−Ｑ４３５−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｑ４３６−Ｏ）_y−Ｑ４３７（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ４３８、−ＯＣ（Ｏ）−Ｏ−Ｑ４３９、−ＯＣ（Ｏ）−ＮＨＱ４４０、−Ｏ−Ｃ（Ｏ）−ＮＱ４４１Ｑ４４２、−ＯＰ（Ｏ）（ＯＱ４４３）（ＯＱ４４４）、−ＯＳｉ（Ｑ４４５）（Ｑ４４６）（Ｑ４４７）、−ＯＳ（Ｏ₂）−Ｑ４４８、−ＮＨＣ（Ｏ）−Ｑ４４９、−ＮＱ４５０Ｃ（Ｏ）−Ｑ４５１、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ４５２、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ４５３、−ＮＨ−Ｃ（Ｏ）−ＮＱ４５４Ｑ４５５、−ＮＱ４５６ａ−Ｃ（Ｏ）−Ｏ−Ｑ４５６ｂ、−ＮＱ４５６ｃ−Ｃ（Ｏ）−ＮＨ−Ｑ４５６ｄ、−ＮＱ４５６ｅ−Ｃ（Ｏ）−ＮＱ４５６ｆＱ４５６ｇ、−ＮＨＳ（Ｏ₂）−Ｑ４５６ｈ、−ＮＱ４５６ｉＳ（Ｏ₂）−Ｑ４５６ｊ、−Ｓ−Ｑ４５６ｋ、−Ｓ（Ｏ）−Ｑ４５６ｌ、−Ｓ（Ｏ₂）−Ｑ４５６ｍ、−Ｓ（Ｏ₂）ＮＨ−Ｑ４５６ｎ、−Ｓ（Ｏ₂）ＮＱ４５６ｏＱ４５６ｐ、−Ｓ（Ｏ₂）Ｏ−Ｑ４５６ｑ、−Ｐ（Ｏ）（ＯＱ４５６ｒ）（ＯＱ４５６ｓ）、−Ｓｉ（Ｑ４５６ｔ）（Ｑ４５６ｕ）（Ｑ４５６ｖ）"；
その際、Ｑ４２６、Ｑ４２７、Ｑ４２８、Ｑ４２９、Ｑ４３０、Ｑ４３１、Ｑ４３２、Ｑ４３３、Ｑ４３４、Ｑ４３５、Ｑ４３６、Ｑ４３７、Ｑ４３８、Ｑ４３９、Ｑ４４０、Ｑ４４１、Ｑ４４２、Ｑ４４３、Ｑ４４４、Ｑ４４５、Ｑ４４６ａ、Ｑ４４６ｂ、Ｑ４４６ｃ、Ｑ４４６ｄ、Ｑ４４６ｅ、Ｑ４４６ｆ、Ｑ４４６ｇ、Ｑ４４６ｈ、Ｑ４４６ｉ、Ｑ４４６ｊ、Ｑ４４６ｋ、Ｑ４４６ｌ、Ｑ４４６ｍ、Ｑ４４６ｎ、Ｑ４４６ｏ、Ｑ４４６ｐ、Ｑ４４６ｑ、Ｑ４４６ｒ、Ｑ４４６ｓ、Ｑ４４６ｔ、Ｑ４４６ｕ、Ｑ４４６ｖは、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ４３２、Ｑ４３３及び／又はＱ４４１、Ｑ４４２及び／又はＱ４５４、Ｑ４５５及び／又はＱ４５６ｆ、Ｑ４５６ｇ及び／又はＱ４５６ｏ、Ｑ４５６ｐは、一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ３、Ｚ４の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ３、Ｚ４のどちらも、以下のものからなる群から選択されない：
（ｄ）水素；
（ｅ）ハロゲン、Ｆ、Ｃｌ、Ｂｒ、Ｉ；
（ｆ）非置換もしくは置換されたアルキルもしくはＣ₉〜Ｃ₃₀−アルキル、
その際、場合により、前記のアルキル基もしくはＣ₉〜Ｃ₃₀−アルキル基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ４５７、−ＮＱ４５８Ｑ４５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ４６０、−Ｃ（Ｏ）Ｏ−Ｑ４６１、−Ｃ（Ｏ）ＮＨ−Ｑ４６２、−Ｃ（Ｏ）ＮＱ４６３Ｑ４６４、−Ｏ−Ｑ４６５、−Ｏ（−Ｑ４６６−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｑ４６７−Ｏ）_z−Ｑ４６８（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ４６９、−ＯＣ（Ｏ）−Ｏ−Ｑ４７０、−ＯＣ（Ｏ）−ＮＨＱ４７１、−Ｏ−Ｃ（Ｏ）−ＮＱ４７２Ｑ４７３、−ＯＰ（Ｏ）（ＯＱ４７４）（ＯＱ４７５）、−ＯＳｉ（Ｑ４７６）（Ｑ４７７）（Ｑ４７８）、−ＯＳ（Ｏ₂）−Ｑ４７９、−ＮＨＣ（Ｏ）−Ｑ４８０、−ＮＱ４８１Ｃ（Ｏ）−Ｑ４８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ４８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ４８４、−ＮＨ−Ｃ（Ｏ）−ＮＱ４８５Ｑ４８６、−ＮＱ４８７−Ｃ（Ｏ）−Ｏ−Ｑ４８８、−ＮＱ４８９−Ｃ（Ｏ）−ＮＨ−Ｑ４９０、−ＮＱ４９１−Ｃ（Ｏ）−ＮＱ４９２Ｑ４９３、−ＮＨＳ（Ｏ₂）−Ｑ４９４、−ＮＱ４９５Ｓ（Ｏ₂）−Ｑ４９６、−Ｓ−Ｑ４９７、−Ｓ（Ｏ）−Ｑ４９８、−Ｓ（Ｏ₂）−Ｑ４９９、−Ｓ（Ｏ₂）ＮＨ−Ｑ５００、−Ｓ（Ｏ₂）ＮＱ５０１Ｑ５０２、−Ｓ（Ｏ₂）Ｏ−Ｑ５０３、−Ｐ（Ｏ）（ＯＱ５０４）（ＯＱ５０５）、−Ｓｉ（Ｑ５０６）（Ｑ５０７）（Ｑ５０８）"；
その際、Ｑ４５７、Ｑ４５８、Ｑ４５９、Ｑ４６０、Ｑ４６１、Ｑ４６２、Ｑ４６３、Ｑ４６４、Ｑ４６５、Ｑ４６６、Ｑ４６７、Ｑ４６８、Ｑ４６９、Ｑ４７０、Ｑ４７１、Ｑ４７２、Ｑ４７３、Ｑ４７４、Ｑ４７５、Ｑ４７６、Ｑ４７７、Ｑ４７８、Ｑ４７９、Ｑ４８０、Ｑ４８１、Ｑ４８２、Ｑ４８３、Ｑ４８４、Ｑ４８５、Ｑ４８６、Ｑ４８７、Ｑ４８８、Ｑ４８９、Ｑ４９０、Ｑ４９１、Ｑ４９２、Ｑ４９３、Ｑ４９４、Ｑ４９５、Ｑ４９６、Ｑ４９７、Ｑ４９８、Ｑ４９９、Ｑ５００、Ｑ５０１、Ｑ５０２、Ｑ５０３、Ｑ５０４、Ｑ５０５、Ｑ５０６、Ｑ５０７、Ｑ５０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ４６３、Ｑ４６４及び／又はＱ４７２、Ｑ４７３及び／又はＱ４８５、Ｑ４８６及び／又はＱ４９２、Ｑ４９３及び／又はＱ５０１、Ｑ５０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ５０９、−ＮＱ５１０Ｑ５１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ５１２、−Ｃ（Ｏ）Ｏ−Ｑ５１３、−Ｃ（Ｏ）ＮＨ−Ｑ５１４、−Ｃ（Ｏ）ＮＱ５１５Ｑ５１６、−Ｏ−Ｑ５１７、−Ｏ（−Ｑ５１８−Ｏ）_a−Ｈ（ａ＝１、２、３、４、５）、−Ｏ（−Ｑ５１９−Ｏ）_a−Ｑ５２０（ａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ５２１、−ＯＣ（Ｏ）−Ｏ−Ｑ５２２、−ＯＣ（Ｏ）−ＮＨＱ５２３、−Ｏ−Ｃ（Ｏ）−ＮＱ５２４Ｑ５２５、−ＯＰ（Ｏ）（ＯＱ５２６）（ＯＱ５２７）、−ＯＳｉ（Ｑ５２８）（Ｑ５２９）（Ｑ５３０）、−ＯＳ（Ｏ₂）−Ｑ５３１、−ＮＨＣ（Ｏ）−Ｑ５３２、−ＮＱ５３３Ｃ（Ｏ）−Ｑ５３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ５３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ５３６、−ＮＨ−Ｃ（Ｏ）−ＮＱ５３７Ｑ５３８、−ＮＱ５３９−Ｃ（Ｏ）−Ｏ−Ｑ５４０、−ＮＱ５４１−Ｃ（Ｏ）−ＮＨ−Ｑ５４２、−ＮＱ５４３−Ｃ（Ｏ）−ＮＱ５４４Ｑ５４５、−ＮＨＳ（Ｏ₂）−Ｑ５４６、−ＮＱ５４７Ｓ（Ｏ₂）−Ｑ５４８、−Ｓ−Ｑ５４９、−Ｓ（Ｏ）−Ｑ５５０、−Ｓ（Ｏ₂）−Ｑ５５１、−Ｓ（Ｏ₂）ＮＨ−Ｑ５５２、−Ｓ（Ｏ₂）ＮＱ５５３Ｑ５５４、−Ｓ（Ｏ₂）Ｏ−Ｑ５５５、−Ｐ（Ｏ）（ＯＱ５５６）（ＯＱ５５７）、−Ｓｉ（Ｑ５５８）（Ｑ５５９）（Ｑ５６０）"；
その際、Ｑ５０９、Ｑ５１０、Ｑ５１１、Ｑ５１２、Ｑ５１３、Ｑ５１４、Ｑ５１５、Ｑ５１６、Ｑ５１７、Ｑ５１８、Ｑ５１９、Ｑ５２０、Ｑ５２１、Ｑ５２２、Ｑ５２３、Ｑ５２４、Ｑ５２５、Ｑ５２６、Ｑ５２７、Ｑ５２８、Ｑ５２９、Ｑ５３０、Ｑ５３１、Ｑ５３２、Ｑ５３３、Ｑ５３４、Ｑ５３５、Ｑ５３６、Ｑ５３７、Ｑ５３８、Ｑ５３９、Ｑ５４０、Ｑ５４１、Ｑ５４２、Ｑ５４３、Ｑ５４４、Ｑ５４５、Ｑ５４６、Ｑ５４７、Ｑ５４８、Ｑ５４９、Ｑ５５０、Ｑ５５１、Ｑ５５２、Ｑ５５３、Ｑ５５４、Ｑ５５５、Ｑ５５６、Ｑ５５７、Ｑ５５８、Ｑ５５９、Ｑ５６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ５１５、Ｑ５１６及び／又はＱ５２４、Ｑ５２５及び／又はＱ５３７、Ｑ５３８及び／又はＱ５４４、Ｑ５４５及び／又はＱ５５３、Ｑ５５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ５６１、−ＮＱ５６２Ｑ５６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ５６４、−Ｃ（Ｏ）Ｏ−Ｑ５６５、−Ｃ（Ｏ）ＮＨ−Ｑ５６６、−Ｃ（Ｏ）ＮＱ５６７Ｑ５６８、−Ｏ−Ｑ５６９、−Ｏ（−Ｑ５７０−Ｏ）_b−Ｈ（ｂ＝１、２、３、４、５）、−Ｏ（−Ｑ５７１−Ｏ）_b−Ｑ５７２（ｂ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ５７３、−ＯＣ（Ｏ）−Ｏ−Ｑ５７４、−ＯＣ（Ｏ）−ＮＨＱ５７５、−Ｏ−Ｃ（Ｏ）−ＮＱ５７６Ｑ５７７、−ＯＰ（Ｏ）（ＯＱ５７８）（ＯＱ５７９）、−ＯＳｉ（Ｑ５８０）（Ｑ５８１）（Ｑ５８２）、−ＯＳ（Ｏ₂）−Ｑ５８３、−ＮＨＣ（Ｏ）−Ｑ５８４、−ＮＱ５８５Ｃ（Ｏ）−Ｑ５８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ５８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ５８８、−ＮＨ−Ｃ（Ｏ）−ＮＱ５８９Ｑ５９０、−ＮＱ５９１−Ｃ（Ｏ）−Ｏ−Ｑ５９２、−ＮＱ５９３−Ｃ（Ｏ）−ＮＨ−Ｑ５９４、−ＮＱ５９５−Ｃ（Ｏ）−ＮＱ５９６Ｑ５９７、−ＮＨＳ（Ｏ₂）−Ｑ５９８、−ＮＱ５９９Ｓ（Ｏ₂）−Ｑ６００、−Ｓ−Ｑ６０１、−Ｓ（Ｏ）−Ｑ６０２、−Ｓ（Ｏ₂）−Ｑ６０３、−Ｓ（Ｏ₂）ＮＨ−Ｑ６０４、−Ｓ（Ｏ₂）ＮＱ６０５Ｑ６０６、−Ｓ（Ｏ₂）Ｏ−Ｑ６０７、−Ｐ（Ｏ）（ＯＱ６０８）（ＯＱ６０９）、−Ｓｉ（Ｑ６１０）（Ｑ６１１）（Ｑ６１２）"；
その際、Ｑ５６１、Ｑ５６２、Ｑ５６３、Ｑ５６４、Ｑ５６５、Ｑ５６６、Ｑ５６７、Ｑ５６８、Ｑ５６９、Ｑ５７０、Ｑ５７１、Ｑ５７２、Ｑ５７３、Ｑ５７４、Ｑ５７５、Ｑ５７６、Ｑ５７７、Ｑ５７８、Ｑ５７９、Ｑ５８０、Ｑ５８１、Ｑ５８２、Ｑ５８３、Ｑ５８４、Ｑ５８５、Ｑ５８６、Ｑ５８７、Ｑ５８８、Ｑ５８９、Ｑ５９０、Ｑ５９１、Ｑ５９２、Ｑ５９３、Ｑ５９４、Ｑ５９５、Ｑ５９６、Ｑ５９７、Ｑ５９８、Ｑ５９９、Ｑ６００、Ｑ６０１、Ｑ６０２、Ｑ６０３、Ｑ６０４、Ｑ６０５、Ｑ６０６、Ｑ６０７、Ｑ６０８、Ｑ６０９、Ｑ６１０、Ｑ６１１、Ｑ６１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ５６７、Ｑ５６８及び／又はＱ５７６、Ｑ５７７及び／又はＱ５８９、Ｑ５９０及び／又はＱ５９６、Ｑ５９７及び／又はＱ６０５、Ｑ６０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｇ）非置換もしくは置換されたアリール、
その際、場合により、前記のアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ６１３、−ＮＱ６１４Ｑ６１５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ６１６、−Ｃ（Ｏ）Ｏ−Ｑ６１７、−Ｃ（Ｏ）ＮＨ−Ｑ６１８、−Ｃ（Ｏ）ＮＱ６１９Ｑ６２０、−Ｏ−Ｑ６２１、−Ｏ（−Ｑ６２２−Ｏ）_c−Ｈ（ｃ＝１、２、３、４、５）、−Ｏ（−Ｑ６２３−Ｏ）_c−Ｑ６２４（ｃ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ６２５、−ＯＣ（Ｏ）−Ｏ−Ｑ６２６、−ＯＣ（Ｏ）−ＮＨＱ６２７、−Ｏ−Ｃ（Ｏ）−ＮＱ６２８Ｑ６２９、−ＯＰ（Ｏ）（ＯＱ６３０）（ＯＱ６３１）、−ＯＳｉ（Ｑ６３２）（Ｑ６３３）（Ｑ６３４）、−ＯＳ（Ｏ₂）−Ｑ６３５、−ＮＨＣ（Ｏ）−Ｑ６３６、−ＮＱ６３７Ｃ（Ｏ）−Ｑ６３８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ６３９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ６４０、−ＮＨ−Ｃ（Ｏ）−ＮＱ６４１Ｑ６４２、−ＮＱ６４３−Ｃ（Ｏ）−Ｏ−Ｑ６４４、−ＮＱ６４５−Ｃ（Ｏ）−ＮＨ−Ｑ６４６、−ＮＱ６４７−Ｃ（Ｏ）−ＮＱ６４８Ｑ６４９、−ＮＨＳ（Ｏ₂）−Ｑ６５０、−ＮＱ６５１Ｓ（Ｏ₂）−Ｑ６５２、−Ｓ−Ｑ６５３、−Ｓ（Ｏ）−Ｑ６５４、−Ｓ（Ｏ₂）−Ｑ６５５、−Ｓ（Ｏ₂）ＮＨ−Ｑ６５６、−Ｓ（Ｏ₂）ＮＱ６５７Ｑ６５８、−Ｓ（Ｏ₂）Ｏ−Ｑ６５９、−Ｐ（Ｏ）（ＯＱ６６０）（ＯＱ６６１）、−Ｓｉ（Ｑ６６２）（Ｑ６６３）（Ｑ６６４）"；
その際、Ｑ６１３、Ｑ６１４、Ｑ６１５、Ｑ６１６、Ｑ６１７、Ｑ６１８、Ｑ６１９、Ｑ６２０、Ｑ６２１、Ｑ６２２、Ｑ６２３、Ｑ６２４、Ｑ６２５、Ｑ６２６、Ｑ６２７、Ｑ６２８、Ｑ６２９、Ｑ６３０、Ｑ６３１、Ｑ６３２、Ｑ６３３、Ｑ６３４、Ｑ６３５、Ｑ６３６、Ｑ６３７、Ｑ６３８、Ｑ６３９、Ｑ６４０、Ｑ６４１、Ｑ６４２、Ｑ６４３、Ｑ６４４、Ｑ６４５、Ｑ６４６、Ｑ６４７、Ｑ６４８、Ｑ６４９、Ｑ６５０、Ｑ６５１、Ｑ６５２、Ｑ６５３、Ｑ６５４、Ｑ６５５、Ｑ６５６、Ｑ６５７、Ｑ６５８、Ｑ６５９、Ｑ６６０、Ｑ６６１、Ｑ６６２、Ｑ６６３、Ｑ６６４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ６１９、Ｑ６２０及び／又はＱ６２８、Ｑ６２９及び／又はＱ６４１、Ｑ６４２及び／又はＱ６４８、Ｑ６４９及び／又はＱ６５７、Ｑ６５８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ６６５、−ＮＱ６６６Ｑ６６７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ６６８、−Ｃ（Ｏ）Ｏ−Ｑ６６９、−Ｃ（Ｏ）ＮＨ−Ｑ６７０、−Ｃ（Ｏ）ＮＱ６７１Ｑ６７２、−Ｏ−Ｑ６７３、−Ｏ（−Ｑ６７４−Ｏ）_d−Ｈ（ｄ＝１、２、３、４、５）、−Ｏ（−Ｑ６７５−Ｏ）_d−Ｑ６７６（ｄ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ６７７、−ＯＣ（Ｏ）−Ｏ−Ｑ６７８、−ＯＣ（Ｏ）−ＮＨＱ６７９、−Ｏ−Ｃ（Ｏ）−ＮＱ６８０Ｑ６８１、−ＯＰ（Ｏ）（ＯＱ６８２）（ＯＱ６８３）、−ＯＳｉ（Ｑ６８４）（Ｑ６８５）（Ｑ６８６）、−ＯＳ（Ｏ₂）−Ｑ６８７、−ＮＨＣ（Ｏ）−Ｑ６８８、−ＮＱ６８９Ｃ（Ｏ）−Ｑ６９０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ６９１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ６９２、−ＮＨ−Ｃ（Ｏ）−ＮＱ６９３Ｑ６９４、−ＮＱ６９５−Ｃ（Ｏ）−Ｏ−Ｑ６９６、−ＮＱ６９７−Ｃ（Ｏ）−ＮＨ−Ｑ６９８、−ＮＱ６９９−Ｃ（Ｏ）−ＮＱ７００Ｑ７０１、−ＮＨＳ（Ｏ₂）−Ｑ７０２、−ＮＱ７０３Ｓ（Ｏ₂）−Ｑ７０４、−Ｓ−Ｑ７０５、−Ｓ（Ｏ）−Ｑ７０６、−Ｓ（Ｏ₂）−Ｑ７０７、−Ｓ（Ｏ₂）ＮＨ−Ｑ７０８、−Ｓ（Ｏ₂）ＮＱ７０９Ｑ７１０、−Ｓ（Ｏ₂）Ｏ−Ｑ７１１、−Ｐ（Ｏ）（ＯＱ７１２）（ＯＱ７１３）、−Ｓｉ（Ｑ７１４）（Ｑ７１５）（Ｑ７１６）"；
その際、Ｑ６６５、Ｑ６６６、Ｑ６６７、Ｑ６６８、Ｑ６６９、Ｑ６７０、Ｑ６７１、Ｑ６７２、Ｑ６７３、Ｑ６７４、Ｑ６７５、Ｑ６７６、Ｑ６７７、Ｑ６７８、Ｑ６７９、Ｑ６８０、Ｑ６８１、Ｑ６８２、Ｑ６８３、Ｑ６８４、Ｑ６８５、Ｑ６８６、Ｑ６８７、Ｑ６８８、Ｑ６８９、Ｑ６９０、Ｑ６９１、Ｑ６９２、Ｑ６９３、Ｑ６９４、Ｑ６９５、Ｑ６９６、Ｑ６９７、Ｑ６９８、Ｑ６９９、Ｑ７００、Ｑ７０１、Ｑ７０２、Ｑ７０３、Ｑ７０４、Ｑ７０５、Ｑ７０６、Ｑ７０７、Ｑ７０８、Ｑ７０９、Ｑ７１０、Ｑ７１１、Ｑ７１２、Ｑ７１３、Ｑ７１４、Ｑ７１５、Ｑ７１６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ６７１、Ｑ６７２及び／又はＱ６８０、Ｑ６８１及び／又はＱ６９３、Ｑ６９４及び／又はＱ７００、Ｑ７０１及び／又はＱ７０９、Ｑ７１０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ７１７、−ＮＱ７１８Ｑ７１９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ７２０、−Ｃ（Ｏ）Ｏ−Ｑ７２１、−Ｃ（Ｏ）ＮＨ−Ｑ７２２、−Ｃ（Ｏ）ＮＱ７２３Ｑ７２４、−Ｏ−Ｑ７２５、−Ｏ（−Ｑ７２６−Ｏ）_e−Ｈ（ｅ＝１、２、３、４、５）、−Ｏ（−Ｑ７２７−Ｏ）_e−Ｑ７２８（ｅ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ７２９、−ＯＣ（Ｏ）−Ｏ−Ｑ７３０、−ＯＣ（Ｏ）−ＮＨＱ７３１、−Ｏ−Ｃ（Ｏ）−ＮＱ７３２Ｑ７３３、−ＯＰ（Ｏ）（ＯＱ７３４）（ＯＱ７３５）、−ＯＳｉ（Ｑ７３６）（Ｑ７３７）（Ｑ７３８）、−ＯＳ（Ｏ₂）−Ｑ７３９、−ＮＨＣ（Ｏ）−Ｑ７４０、−ＮＱ７４１Ｃ（Ｏ）−Ｑ７４２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ７４３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ７４４、−ＮＨ−Ｃ（Ｏ）−ＮＱ７４５Ｑ７４６、−ＮＱ７４７−Ｃ（Ｏ）−Ｏ−Ｑ７４８、−ＮＱ７４９−Ｃ（Ｏ）−ＮＨ−Ｑ７５０、−ＮＱ７５１−Ｃ（Ｏ）−ＮＱ７５２Ｑ７５３、−ＮＨＳ（Ｏ₂）−Ｑ７５４、−ＮＱ７５５Ｓ（Ｏ₂）−Ｑ７５６、−Ｓ−Ｑ７５７、−Ｓ（Ｏ）−Ｑ７５８、−Ｓ（Ｏ₂）−Ｑ７５９、−Ｓ（Ｏ₂）ＮＨ−Ｑ７６０、−Ｓ（Ｏ₂）ＮＱ７６１Ｑ７６２、−Ｓ（Ｏ₂）Ｏ−Ｑ７６３、−Ｐ（Ｏ）（ＯＱ７６４）（ＯＱ７６５）、−Ｓｉ（Ｑ７６６）（Ｑ７６７）（Ｑ７６８）"；
その際、Ｑ７１７、Ｑ７１８、Ｑ７１９、Ｑ７２０、Ｑ７２１、Ｑ７２２、Ｑ７２３、Ｑ７２４、Ｑ７２５、Ｑ７２６、Ｑ７２７、Ｑ７２８、Ｑ７２９、Ｑ７３０、Ｑ７３１、Ｑ７３２、Ｑ７３３、Ｑ７３４、Ｑ７３５、Ｑ７３６、Ｑ７３７、Ｑ７３８、Ｑ７３９、Ｑ７４０、Ｑ７４１、Ｑ７４２、Ｑ７４３、Ｑ７４４、Ｑ７４５、Ｑ７４６、Ｑ７４７、Ｑ７４８、Ｑ７４９、Ｑ７５０、Ｑ７５１、Ｑ７５２、Ｑ７５３、Ｑ７５４、Ｑ７５５、Ｑ７５６、Ｑ７５７、Ｑ７５８、Ｑ７５９、Ｑ７６０、Ｑ７６１、Ｑ７６２、Ｑ７６３、Ｑ７６４、Ｑ７６５、Ｑ７６６、Ｑ７６７、Ｑ７６８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ７２３、Ｑ７２４及び／又はＱ７３２、Ｑ７３３及び／又はＱ７４５、Ｑ７４６及び／又はＱ７５２、Ｑ７５３及び／又はＱ７６１、Ｑ７６２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｈ）非置換もしくは置換されたヘテロアリール、
その際、場合により、前記のヘテロアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ７６９、−ＮＱ７７０Ｑ７７１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ７７２、−Ｃ（Ｏ）Ｏ−Ｑ７７３、−Ｃ（Ｏ）ＮＨ−Ｑ７７４、−Ｃ（Ｏ）ＮＱ７７５Ｑ７７６、−Ｏ−Ｑ７７７、−Ｏ（−Ｑ７７８−Ｏ）_f−Ｈ（ｆ＝１、２、３、４、５）、−Ｏ（−Ｑ７７９−Ｏ）_f−Ｑ７８０（ｆ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ７８１、−ＯＣ（Ｏ）−Ｏ−Ｑ７８２、−ＯＣ（Ｏ）−ＮＨＱ７８３、−Ｏ−Ｃ（Ｏ）−ＮＱ７８４Ｑ７８５、−ＯＰ（Ｏ）（ＯＱ７８６）（ＯＱ７８７）、−ＯＳｉ（Ｑ７８８）（Ｑ７８９）（Ｑ７９０）、−ＯＳ（Ｏ₂）−Ｑ７９１、−ＮＨＣ（Ｏ）−Ｑ７９２、−ＮＱ７９３Ｃ（Ｏ）−Ｑ７９４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ７９５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ７９６、−ＮＨ−Ｃ（Ｏ）−ＮＱ７９７Ｑ７９８、−ＮＱ７９９−Ｃ（Ｏ）−Ｏ−Ｑ８００、−ＮＱ８０１−Ｃ（Ｏ）−ＮＨ−Ｑ８０２、−ＮＱ８０３−Ｃ（Ｏ）−ＮＱ８０４Ｑ８０５、−ＮＨＳ（Ｏ₂）−Ｑ８０６、−ＮＱ８０７Ｓ（Ｏ₂）−Ｑ８０８、−Ｓ−Ｑ８０９、−Ｓ（Ｏ）−Ｑ８１０、−Ｓ（Ｏ₂）−Ｑ８１１、−Ｓ（Ｏ₂）ＮＨ−Ｑ８１２、−Ｓ（Ｏ₂）ＮＱ８１３Ｑ８１４、−Ｓ（Ｏ₂）Ｏ−Ｑ８１５、−Ｐ（Ｏ）（ＯＱ８１６）（ＯＱ８１７）、−Ｓｉ（Ｑ８１８）（Ｑ８１９）（Ｑ８２０）"；
その際、Ｑ７６９、Ｑ７７０、Ｑ７７１、Ｑ７７２、Ｑ７７３、Ｑ７７４、Ｑ７７５、Ｑ７７６、Ｑ７７７、Ｑ７７８、Ｑ７７９、Ｑ７８０、Ｑ７８１、Ｑ７８２、Ｑ７８３、Ｑ７８４、Ｑ７８５、Ｑ７８６、Ｑ７８７、Ｑ７８８、Ｑ７８９、Ｑ７９０、Ｑ７９１、Ｑ７９２、Ｑ７９３、Ｑ７９４、Ｑ７９５、Ｑ７９６、Ｑ７９７、Ｑ７９８、Ｑ７９９、Ｑ８００、Ｑ８０１、Ｑ８０２、Ｑ８０３、Ｑ８０４、Ｑ８０５、Ｑ８０６、Ｑ８０７、Ｑ８０８、Ｑ８０９、Ｑ８１０、Ｑ８１１、Ｑ８１２、Ｑ８１３、Ｑ８１４、Ｑ８１５、Ｑ８１６、Ｑ８１７、Ｑ８１８、Ｑ８１９、Ｑ８２０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ７７５、Ｑ７７６及び／又はＱ７８４、Ｑ７８５及び／又はＱ７９７、Ｑ７９８及び／又はＱ８０４、Ｑ８０５及び／又はＱ８１３、Ｑ８１４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ８２１、−ＮＱ８２２Ｑ８２３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ８２４、−Ｃ（Ｏ）Ｏ−Ｑ８２５、−Ｃ（Ｏ）ＮＨ−Ｑ８２６、−Ｃ（Ｏ）ＮＱ８２７Ｑ８２８、−Ｏ−Ｑ８２９、−Ｏ（−Ｑ８３０−Ｏ）_g−Ｈ（ｇ＝１、２、３、４、５）、−Ｏ（−Ｑ８３１−Ｏ）_g−Ｑ８３２（ｇ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ８３３、−ＯＣ（Ｏ）−Ｏ−Ｑ８３４、−ＯＣ（Ｏ）−ＮＨＱ８３５、−Ｏ−Ｃ（Ｏ）−ＮＱ８３６Ｑ８３７、−ＯＰ（Ｏ）（ＯＱ８３８）（ＯＱ８３９）、−ＯＳｉ（Ｑ８４０）（Ｑ８４１）（Ｑ８４２）、−ＯＳ（Ｏ₂）−Ｑ８４３、−ＮＨＣ（Ｏ）−Ｑ８４４、−ＮＱ８４５Ｃ（Ｏ）−Ｑ８４６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ８４７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ８４８、−ＮＨ−Ｃ（Ｏ）−ＮＱ８４９Ｑ８５０、−ＮＱ８５１−Ｃ（Ｏ）−Ｏ−Ｑ８５２、−ＮＱ８５３−Ｃ（Ｏ）−ＮＨ−Ｑ８５４、−ＮＱ８５５−Ｃ（Ｏ）−ＮＱ８５６Ｑ８５７、−ＮＨＳ（Ｏ₂）−Ｑ８５８、−ＮＱ８５９Ｓ（Ｏ₂）−Ｑ８６０、−Ｓ−Ｑ８６１、−Ｓ（Ｏ）−Ｑ８６２、−Ｓ（Ｏ₂）−Ｑ８６３、−Ｓ（Ｏ₂）ＮＨ−Ｑ８６４、−Ｓ（Ｏ₂）ＮＱ８６５Ｑ８６６、−Ｓ（Ｏ₂）Ｏ−Ｑ８６７、−Ｐ（Ｏ）（ＯＱ８６８）（ＯＱ８６９）、−Ｓｉ（Ｑ８７０）（Ｑ８７１）（Ｑ８７２）"；
その際、Ｑ８２１、Ｑ８２２、Ｑ８２３、Ｑ８２４、Ｑ８２５、Ｑ８２６、Ｑ８２７、Ｑ８２８、Ｑ８２９、Ｑ８３０、Ｑ８３１、Ｑ８３２、Ｑ８３３、Ｑ８３４、Ｑ８３５、Ｑ８３６、Ｑ８３７、Ｑ８３８、Ｑ８３９、Ｑ８４０、Ｑ８４１、Ｑ８４２、Ｑ８４３、Ｑ８４４、Ｑ８４５、Ｑ８４６、Ｑ８４７、Ｑ８４８、Ｑ８４９、Ｑ８５０、Ｑ８５１、Ｑ８５２、Ｑ８５３、Ｑ８５４、Ｑ８５５、Ｑ８５６、Ｑ８５７、Ｑ８５８、Ｑ８５９、Ｑ８６０、Ｑ８６１、Ｑ８６２、Ｑ８６３、Ｑ８６４、Ｑ８６５、Ｑ８６６、Ｑ８６７、Ｑ８６８、Ｑ８６９、Ｑ８７０、Ｑ８７１、Ｑ８７２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ８２７、Ｑ８２８及び／又はＱ８３６、Ｑ８３７及び／又はＱ８４９、Ｑ８５０及び／又はＱ８５６、Ｑ８５７及び／又はＱ８６５、Ｑ８６６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ８７３、−ＮＱ８７４Ｑ８７５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ８７６、−Ｃ（Ｏ）Ｏ−Ｑ８７７、−Ｃ（Ｏ）ＮＨ−Ｑ８７８、−Ｃ（Ｏ）ＮＱ８７９Ｑ８８０、−Ｏ−Ｑ８８１、−Ｏ（−Ｑ８８２−Ｏ）_h−Ｈ（ｈ＝１、２、３、４、５）、−Ｏ（−Ｑ８８３−Ｏ）_h−Ｑ８８４（ｈ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ８８５、−ＯＣ（Ｏ）−Ｏ−Ｑ８８６、−ＯＣ（Ｏ）−ＮＨＱ８８７、−Ｏ−Ｃ（Ｏ）−ＮＱ８８８Ｑ８８９、−ＯＰ（Ｏ）（ＯＱ８９０）（ＯＱ８９１）、−ＯＳｉ（Ｑ８９２）（Ｑ８９３）（Ｑ８９４）、−ＯＳ（Ｏ₂）−Ｑ８９５、−ＮＨＣ（Ｏ）−Ｑ８９６、−ＮＱ８９７Ｃ（Ｏ）−Ｑ８９８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ８９９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ９００、−ＮＨ−Ｃ（Ｏ）−ＮＱ９０１Ｑ９０２、−ＮＱ９０３−Ｃ（Ｏ）−Ｏ−Ｑ９０４、−ＮＱ９０５−Ｃ（Ｏ）−ＮＨ−Ｑ９０６、−ＮＱ９０７−Ｃ（Ｏ）−ＮＱ９０８Ｑ９０９、−ＮＨＳ（Ｏ₂）−Ｑ９１０、−ＮＱ９１１Ｓ（Ｏ₂）−Ｑ９１２、−Ｓ−Ｑ９１３、−Ｓ（Ｏ）−Ｑ９１４、−Ｓ（Ｏ₂）−Ｑ９１５、−Ｓ（Ｏ₂）ＮＨ−Ｑ９１６、−Ｓ（Ｏ₂）ＮＱ９１７Ｑ９１８、−Ｓ（Ｏ₂）Ｏ−Ｑ９１９、−Ｐ（Ｏ）（ＯＱ９２０）（ＯＱ９２１）、−Ｓｉ（Ｑ９２２）（Ｑ９２３）（Ｑ９２４）"；
その際、Ｑ８７３、Ｑ８７４、Ｑ８７５、Ｑ８７６、Ｑ８７７、Ｑ８７８、Ｑ８７９、Ｑ８８０、Ｑ８８１、Ｑ８８２、Ｑ８８３、Ｑ８８４、Ｑ８８５、Ｑ８８６、Ｑ８８７、Ｑ８８８、Ｑ８８９、Ｑ８９０、Ｑ８９１、Ｑ８９２、Ｑ８９３、Ｑ８９４、Ｑ８９５、Ｑ８９６、Ｑ８９７、Ｑ８９８、Ｑ８９９、Ｑ９００、Ｑ９０１、Ｑ９０２、Ｑ９０３、Ｑ９０４、Ｑ９０５、Ｑ９０６、Ｑ９０７、Ｑ９０８、Ｑ９０９、Ｑ９１０、Ｑ９１１、Ｑ９１２、Ｑ９１３、Ｑ９１４、Ｑ９１５、Ｑ９１６、Ｑ９１７、Ｑ９１８、Ｑ９１９、Ｑ９２０、Ｑ９２１、Ｑ９２２、Ｑ９２３、Ｑ９２４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ８７９、Ｑ８８０及び／又はＱ８８８、Ｑ８８９及び／又はＱ９０１、Ｑ９０２及び／又はＱ９０８、Ｑ９０９及び／又はＱ９１７、Ｑ９１８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｊ）ＯＺ６、
その際、Ｚ６は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ９２５、−ＮＱ９２６Ｑ９２７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ９２８、−Ｃ（Ｏ）Ｏ−Ｑ９２９、−Ｃ（Ｏ）ＮＨ−Ｑ９３０、−Ｃ（Ｏ）ＮＱ９３１Ｑ９３２、−Ｏ−Ｑ９３３、−Ｏ（−Ｑ９３４−Ｏ）_i−Ｈ（ｉ＝１、２、３、４、５）、−Ｏ（−Ｑ９３５−Ｏ）_i−Ｑ９３６（ｉ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ９３７、−ＯＣ（Ｏ）−Ｏ−Ｑ９３８、−ＯＣ（Ｏ）−ＮＨＱ９３９、−Ｏ−Ｃ（Ｏ）−ＮＱ９４０Ｑ９４１、−ＯＰ（Ｏ）（ＯＱ９４２）（ＯＱ９４３）、−ＯＳｉ（Ｑ９４４）（Ｑ９４５）（Ｑ９４６）、−ＯＳ（Ｏ₂）−Ｑ９４７、−ＮＨＣ（Ｏ）−Ｑ９４８、−ＮＱ９４９Ｃ（Ｏ）−Ｑ９５０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ９５１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ９５２、−ＮＨ−Ｃ（Ｏ）−ＮＱ９５３Ｑ９５４、−ＮＱ９５５−Ｃ（Ｏ）−Ｏ−Ｑ９５６、−ＮＱ９５７−Ｃ（Ｏ）−ＮＨ−Ｑ９５８、−ＮＱ９５９−Ｃ（Ｏ）−ＮＱ９６０Ｑ９６１、−ＮＨＳ（Ｏ₂）−Ｑ９６２、−ＮＱ９６３Ｓ（Ｏ₂）−Ｑ９６４、−Ｓ−Ｑ９６５、−Ｓ（Ｏ）−Ｑ９６６、−Ｓ（Ｏ₂）−Ｑ９６７、−Ｓ（Ｏ₂）ＮＨ−Ｑ９６８、−Ｓ（Ｏ₂）ＮＱ９６９Ｑ９７０、−Ｓ（Ｏ₂）Ｏ−Ｑ９７１、−Ｐ（Ｏ）（ＯＱ９７２）（ＯＱ９７３）、−Ｓｉ（Ｑ９７４）（Ｑ９７５）（Ｑ９７６）"；
その際、Ｑ９２５、Ｑ９２６、Ｑ９２７、Ｑ９２８、Ｑ９２９、Ｑ９３０、Ｑ９３１、Ｑ９３２、Ｑ９３３、Ｑ９３４、Ｑ９３５、Ｑ９３６、Ｑ９３７、Ｑ９３８、Ｑ９３９、Ｑ９４０、Ｑ９４１、Ｑ９４２、Ｑ９４３、Ｑ９４４、Ｑ９４５、Ｑ９４６、Ｑ９４７、Ｑ９４８、Ｑ９４９、Ｑ９５０、Ｑ９５１、Ｑ９５２、Ｑ９５３、Ｑ９５４、Ｑ９５５、Ｑ９５６、Ｑ９５７、Ｑ９５８、Ｑ９５９、Ｑ９６０、Ｑ９６１、Ｑ９６２、Ｑ９６３、Ｑ９６４、Ｑ９６５、Ｑ９６６、Ｑ９６７、Ｑ９６８、Ｑ９６９、Ｑ９７０、Ｑ９７１、Ｑ９７２、Ｑ９７３、Ｑ９７４、Ｑ９７５、Ｑ９７６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ９３１、Ｑ９３２及び／又はＱ９４０、Ｑ９４１及び／又はＱ９５３、Ｑ９５４及び／又はＱ９６０、Ｑ９６１及び／又はＱ９６９、Ｑ９７０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ９７７、−ＮＱ９７８Ｑ９７９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ９８０、−Ｃ（Ｏ）Ｏ−Ｑ９８１、−Ｃ（Ｏ）ＮＨ−Ｑ９８２、−Ｃ（Ｏ）ＮＱ９８３Ｑ９８４、−Ｏ−Ｑ９８５、−Ｏ（−Ｑ９８６−Ｏ）_j−Ｈ（ｊ＝１、２、３、４、５）、−Ｏ（−Ｑ９８７−Ｏ）_j−Ｑ９８８（ｊ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ９８９、−ＯＣ（Ｏ）−Ｏ−Ｑ９９０、−ＯＣ（Ｏ）−ＮＨＱ９９１、−Ｏ−Ｃ（Ｏ）−ＮＱ９９２Ｑ９９３、−ＯＰ（Ｏ）（ＯＱ９９４）（ＯＱ９９５）、−ＯＳｉ（Ｑ９９６）（Ｑ９９７）（Ｑ９９８）、−ＯＳ（Ｏ₂）−Ｑ９９９、−ＮＨＣ（Ｏ）−Ｑ１０００、−ＮＱ１００１Ｃ（Ｏ）−Ｑ１００２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１００３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１００４、−ＮＨ−Ｃ（Ｏ）−ＮＱ１００５Ｑ１００６、−ＮＱ１００７−Ｃ（Ｏ）−Ｏ−Ｑ１００８、−ＮＱ１００９−Ｃ（Ｏ）−ＮＨ−Ｑ１０１０、−ＮＱ１０１１−Ｃ（Ｏ）−ＮＱ１０１２Ｑ１０１３、−ＮＨＳ（Ｏ₂）−Ｑ１０１４、−ＮＱ１０１５Ｓ（Ｏ₂）−Ｑ１０１６、−Ｓ−Ｑ１０１７、−Ｓ（Ｏ）−Ｑ１０１８、−Ｓ（Ｏ₂）−Ｑ１０１９、−Ｓ（Ｏ₂）ＮＨ−Ｑ１０２０、−Ｓ（Ｏ₂）ＮＱ１０２１Ｑ１０２２、−Ｓ（Ｏ₂）Ｏ−Ｑ１０２３、−Ｐ（Ｏ）（ＯＱ１０２４）（ＯＱ１０２５）、−Ｓｉ（Ｑ１０２６）（Ｑ１０２７）（Ｑ１０２８）"；
その際、Ｑ９７７、Ｑ９７８、Ｑ９７９、Ｑ９８０、Ｑ９８１、Ｑ９８２、Ｑ９８３、Ｑ９８４、Ｑ９８５、Ｑ９８６、Ｑ９８７、Ｑ９８８、Ｑ９８９、Ｑ９９０、Ｑ９９１、Ｑ９９２、Ｑ９９３、Ｑ９９４、Ｑ９９５、Ｑ９９６、Ｑ９９７、Ｑ９９８、Ｑ９９９、Ｑ１０００、Ｑ１００１、Ｑ１００２、Ｑ１００３、Ｑ１００４、Ｑ１００５、Ｑ１００６、Ｑ１００７、Ｑ１００８、Ｑ１００９、Ｑ１０１０、Ｑ１０１１、Ｑ１０１２、Ｑ１０１３、Ｑ１０１４、Ｑ１０１５、Ｑ１０１６、Ｑ１０１７、Ｑ１０１８、Ｑ１０１９、Ｑ１０２０、Ｑ１０２１、Ｑ１０２２、Ｑ１０２３、Ｑ１０２４、Ｑ１０２５、Ｑ１０２６、Ｑ１０２７、Ｑ１０２８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ９８３、Ｑ９８４及び／又はＱ９９２、Ｑ９９３及び／又はＱ１００５、Ｑ１００６及び／又はＱ１０１２、Ｑ１０１３及び／又はＱ１０２１、Ｑ１０２２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｋ）ＳＺ７、
その際、Ｚ７は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ１０２９、−ＮＱ１０３０Ｑ１０３１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ１０３２、−Ｃ（Ｏ）Ｏ−Ｑ１０３３、−Ｃ（Ｏ）ＮＨ−Ｑ１０３４、−Ｃ（Ｏ）ＮＱ１０３５Ｑ１０３６、−Ｏ−Ｑ１０３７、−Ｏ（−Ｑ１０３８−Ｏ）_k−Ｈ（ｋ＝１、２、３、４、５）、−Ｏ（−Ｑ１０３９−Ｏ）_k−Ｑ１０４０（ｋ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ１０４１、−ＯＣ（Ｏ）−Ｏ−Ｑ１０４２、−ＯＣ（Ｏ）−ＮＨＱ１０４３、−Ｏ−Ｃ（Ｏ）−ＮＱ１０４４Ｑ１０４５、−ＯＰ（Ｏ）（ＯＱ１０４６）（ＯＱ１０４７）、−ＯＳｉ（Ｑ１０４８）（Ｑ１０４９）（Ｑ１０５０）、−ＯＳ（Ｏ₂）−Ｑ１０５１、−ＮＨＣ（Ｏ）−Ｑ１０５２、−ＮＱ１０５３Ｃ（Ｏ）−Ｑ１０５４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１０５５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１０５６、−ＮＨ−Ｃ（Ｏ）−ＮＱ１０５７Ｑ１０５８、−ＮＱ１０５９−Ｃ（Ｏ）−Ｏ−Ｑ１０６０、−ＮＱ１０６１−Ｃ（Ｏ）−ＮＨ−Ｑ１０６２、−ＮＱ１０６３−Ｃ（Ｏ）−ＮＱ１０６４Ｑ１０６５、−ＮＨＳ（Ｏ₂）−Ｑ１０６６、−ＮＱ１０６７Ｓ（Ｏ₂）−Ｑ１０６８、−Ｓ−Ｑ１０６９、−Ｓ（Ｏ）−Ｑ１０７０、−Ｓ（Ｏ₂）−Ｑ１０７１、−Ｓ（Ｏ₂）ＮＨ−Ｑ１０７２、−Ｓ（Ｏ₂）ＮＱ１０７３Ｑ１０７４、−Ｓ（Ｏ₂）Ｏ−Ｑ１０７５、−Ｐ（Ｏ）（ＯＱ１０７６）（ＯＱ１０７７）、−Ｓｉ（Ｑ１０７８）（Ｑ１０７９）（Ｑ１０８０）"；
その際、Ｑ１０２９、Ｑ１０３０、Ｑ１０３１、Ｑ１０３２、Ｑ１０３３、Ｑ１０３４、Ｑ１０３５、Ｑ１０３６、Ｑ１０３７、Ｑ１０３８、Ｑ１０３９、Ｑ１０４０、Ｑ１０４１、Ｑ１０４２、Ｑ１０４３、Ｑ１０４４、Ｑ１０４５、Ｑ１０４６、Ｑ１０４７、Ｑ１０４８、Ｑ１０４９、Ｑ１０５０、Ｑ１０５１、Ｑ１０５２、Ｑ１０５３、Ｑ１０５４、Ｑ１０５５、Ｑ１０５６、Ｑ１０５７、Ｑ１０５８、Ｑ１０５９、Ｑ１０６０、Ｑ１０６１、Ｑ１０６２、Ｑ１０６３、Ｑ１０６４、Ｑ１０６５、Ｑ１０６６、Ｑ１０６７、Ｑ１０６８、Ｑ１０６９、Ｑ１０７０、Ｑ１０７１、Ｑ１０７２、Ｑ１０７３、Ｑ１０７４、Ｑ１０７５、Ｑ１０７６、Ｑ１０７７、Ｑ１０７８、Ｑ１０７９、Ｑ１０８０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ１０３５、Ｑ１０３６及び／又はＱ１０４４、Ｑ１０４５及び／又はＱ１０５７、Ｑ１０５８及び／又はＱ１０６４、Ｑ１０６５及び／又はＱ１０７３、Ｑ１０７４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ１０８１、−ＮＱ１０８２Ｑ１０８３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ１０８４、−Ｃ（Ｏ）Ｏ−Ｑ１０８５、−Ｃ（Ｏ）ＮＨ−Ｑ１０８６、−Ｃ（Ｏ）ＮＱ１０８７Ｑ１０８８、−Ｏ−Ｑ１０８９、−Ｏ（−Ｑ１０９０−Ｏ）_l−Ｈ（ｌ＝１、２、３、４、５）、−Ｏ（−Ｑ１０９１−Ｏ）_l−Ｑ１０９２（ｌ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ１０９３、−ＯＣ（Ｏ）−Ｏ−Ｑ１０９４、−ＯＣ（Ｏ）−ＮＨＱ１０９５、−Ｏ−Ｃ（Ｏ）−ＮＱ１０９６Ｑ１０９７、−ＯＰ（Ｏ）（ＯＱ１０９８）（ＯＱ１０９９）、−ＯＳｉ（Ｑ１１００）（Ｑ１１０１）（Ｑ１１０２）、−ＯＳ（Ｏ₂）−Ｑ１１０３、−ＮＨＣ（Ｏ）−Ｑ１１０４、−ＮＱ１１０５Ｃ（Ｏ）−Ｑ１１０６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１１０７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１１０８、−ＮＨ−Ｃ（Ｏ）−ＮＱ１１０９Ｑ１１１０、−ＮＱ１１１１−Ｃ（Ｏ）−Ｏ−Ｑ１１１２、−ＮＱ１１１３−Ｃ（Ｏ）−ＮＨ−Ｑ１１１４、−ＮＱ１１１５−Ｃ（Ｏ）−ＮＱ１１１６Ｑ１１１７、−ＮＨＳ（Ｏ₂）−Ｑ１１１８、−ＮＱ１１１９Ｓ（Ｏ₂）−Ｑ１１２０、−Ｓ−Ｑ１１２１、−Ｓ（Ｏ）−Ｑ１１２２、−Ｓ（Ｏ₂）−Ｑ１１２３、−Ｓ（Ｏ₂）ＮＨ−Ｑ１１２４、−Ｓ（Ｏ₂）ＮＱ１１２５Ｑ１１２６、−Ｓ（Ｏ₂）Ｏ−Ｑ１１２７、−Ｐ（Ｏ）（ＯＱ１１２８）（ＯＱ１１２９）、−Ｓｉ（Ｑ１１３０）（Ｑ１１３１）（Ｑ１１３２）"；
その際、Ｑ１０８１、Ｑ１０８２、Ｑ１０８３、Ｑ１０８４、Ｑ１０８５、Ｑ１０８６、Ｑ１０８７、Ｑ１０８８、Ｑ１０８９、Ｑ１０９０、Ｑ１０９１、Ｑ１０９２、Ｑ１０９３、Ｑ１０９４、Ｑ１０９５、Ｑ１０９６、Ｑ１０９７、Ｑ１０９８、Ｑ１０９９、Ｑ１１００、Ｑ１１０１、Ｑ１１０２、Ｑ１１０３、Ｑ１１０４、Ｑ１１０５、Ｑ１１０６、Ｑ１１０７、Ｑ１１０８、Ｑ１１０９、Ｑ１１１０、Ｑ１１１１、Ｑ１１１２、Ｑ１１１３、Ｑ１１１４、Ｑ１１１５、Ｑ１１１６、Ｑ１１１７、Ｑ１１１８、Ｑ１１１９、Ｑ１１２０、Ｑ１１２１、Ｑ１１２２、Ｑ１１２３、Ｑ１１２４、Ｑ１１２５、Ｑ１１２６、Ｑ１１２７、Ｑ１１２８、Ｑ１１２９、Ｑ１１３０、Ｑ１１３１、Ｑ１１３２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ１０８７、Ｑ１０８８及び／又はＱ１０９６、Ｑ１０９７及び／又はＱ１１０９、Ｑ１１１０及び／又はＱ１１１６、Ｑ１１１７及び／又はＱ１１２５、Ｑ１１２６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｌ）ＮＺ８Ｚ９、
その際、Ｚ８、Ｚ９は、互いに無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−Ｑ１１３３、−Ｃ（Ｏ）Ｏ−Ｑ１１３４、−Ｃ（Ｏ）−ＮＱ１１３５Ｑ１１３６、−Ｓ（Ｏ₂）−Ｑ１１３７、−Ｓ（Ｏ₂）Ｏ−Ｑ１１３８"；
その際、Ｑ１１３３、Ｑ１１３４、Ｑ１１３５、Ｑ１１３６、Ｑ１１３７、Ｑ１１３８は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｑ１１３５、Ｑ１１３６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ１１３９、−ＮＱ１１４０Ｑ１１４１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ１１４２、−Ｃ（Ｏ）Ｏ−Ｑ１１４３、−Ｃ（Ｏ）ＮＨ−Ｑ１１４４、−Ｃ（Ｏ）ＮＱ１１４５Ｑ１１４６、−Ｏ−Ｑ１１４７、−Ｏ（−Ｑ１１４８−Ｏ）_m−Ｈ（ｍ＝１、２、３、４、５）、−Ｏ（−Ｑ１１４９−Ｏ）_m−Ｑ１１５０（ｍ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ１１５１、−ＯＣ（Ｏ）−Ｏ−Ｑ１１５２、−ＯＣ（Ｏ）−ＮＨＱ１１５３、−Ｏ−Ｃ（Ｏ）−ＮＱ１１５４Ｑ１１５５、−ＯＰ（Ｏ）（ＯＱ１１５６）（ＯＱ１１５７）、−ＯＳｉ（Ｑ１１５８）（Ｑ１１５９）（Ｑ１１６０）、−ＯＳ（Ｏ₂）−Ｑ１１６１、−ＮＨＣ（Ｏ）−Ｑ１１６２、−ＮＱ１１６３Ｃ（Ｏ）−Ｑ１１６４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１１６５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１１６６、−ＮＨ−Ｃ（Ｏ）−ＮＱ１１６７Ｑ１１６８、−ＮＱ１１６９−Ｃ（Ｏ）−Ｏ−Ｑ１１７０、−ＮＱ１１７１−Ｃ（Ｏ）−ＮＨ−Ｑ１１７２、−ＮＱ１１７３−Ｃ（Ｏ）−ＮＱ１１７４Ｑ１１７５、−ＮＨＳ（Ｏ₂）−Ｑ１１７６、−ＮＱ１１７７Ｓ（Ｏ₂）−Ｑ１１７８、−Ｓ−Ｑ１１７９、−Ｓ（Ｏ）−Ｑ１１８０、−Ｓ（Ｏ₂）−Ｑ１１８１、−Ｓ（Ｏ₂）ＮＨ−Ｑ１１８２、−Ｓ（Ｏ₂）ＮＱ１１８３Ｑ１１８４、−Ｓ（Ｏ₂）Ｏ−Ｑ１１８５、−Ｐ（Ｏ）（ＯＱ１１８６）（ＯＱ１１８７）、−Ｓｉ（Ｑ１１８８）（Ｑ１１８９）（Ｑ１１９０）"；
その際、Ｑ１１３９、Ｑ１１４０、Ｑ１１４１、Ｑ１１４２、Ｑ１１４３、Ｑ１１４４、Ｑ１１４５、Ｑ１１４６、Ｑ１１４７、Ｑ１１４８、Ｑ１１４９、Ｑ１１５０、Ｑ１１５１、Ｑ１１５２、Ｑ１１５３、Ｑ１１５４、Ｑ１１５５、Ｑ１１５６、Ｑ１１５７、Ｑ１１５８、Ｑ１１５９、Ｑ１１６０、Ｑ１１６１、Ｑ１１６２、Ｑ１１６３、Ｑ１１６４、Ｑ１１６５、Ｑ１１６６、Ｑ１１６７、Ｑ１１６８、Ｑ１１６９、Ｑ１１７０、Ｑ１１７１、Ｑ１１７２、Ｑ１１７３、Ｑ１１７４、Ｑ１１７５、Ｑ１１７６、Ｑ１１７７、Ｑ１１７８、Ｑ１１７９、Ｑ１１８０、Ｑ１１８１、Ｑ１１８２、Ｑ１１８３、Ｑ１１８４、Ｑ１１８５、Ｑ１１８６、Ｑ１１８７、Ｑ１１８８、Ｑ１１８９、Ｑ１１９０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ１１４５、Ｑ１１４６及び／又はＱ１１５４、Ｑ１１５５及び／又はＱ１１６７、Ｑ１１６８及び／又はＱ１１７４、Ｑ１１７５及び／又はＱ１１８３、Ｑ１１８４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＱ１１９１、−ＮＱ１１９２Ｑ１１９３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｑ１１９４、−Ｃ（Ｏ）Ｏ−Ｑ１１９５、−Ｃ（Ｏ）ＮＨ−Ｑ１１９６、−Ｃ（Ｏ）ＮＱ１１９７Ｑ１１９８、−Ｏ−Ｑ１１９９、−Ｏ（−Ｑ１２００−Ｏ）_n−Ｈ（ｎ＝１、２、３、４、５）、−Ｏ（−Ｑ１２０１−Ｏ）_n−Ｑ１２０２（ｎ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｑ１２０３、−ＯＣ（Ｏ）−Ｏ−Ｑ１２０４、−ＯＣ（Ｏ）−ＮＨＱ１２０５、−Ｏ−Ｃ（Ｏ）−ＮＱ１２０６Ｑ１２０７、−ＯＰ（Ｏ）（ＯＱ１２０８）（ＯＱ１２０９）、−ＯＳｉ（Ｑ１２１０）（Ｑ１２１１）（Ｑ１２１２）、−ＯＳ（Ｏ₂）−Ｑ１２１３、−ＮＨＣ（Ｏ）−Ｑ１２１４、−ＮＱ１２１５Ｃ（Ｏ）−Ｑ１２１６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｑ１２１７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｑ１２１８、−ＮＨ−Ｃ（Ｏ）−ＮＱ１２１９Ｑ１２２０、−ＮＱ１２２１−Ｃ（Ｏ）−Ｏ−Ｑ１２２２、−ＮＱ１２２３−Ｃ（Ｏ）−ＮＨ−Ｑ１２２４、−ＮＱ１２２５−Ｃ（Ｏ）−ＮＱ１２２６Ｑ１２２７、−ＮＨＳ（Ｏ₂）−Ｑ１２２８、−ＮＱ１２２９Ｓ（Ｏ₂）−Ｑ１２３０、−Ｓ−Ｑ１２３１、−Ｓ（Ｏ）−Ｑ１２３２、−Ｓ（Ｏ₂）−Ｑ１２３３、−Ｓ（Ｏ₂）ＮＨ−Ｑ１２３４、−Ｓ（Ｏ₂）ＮＱ１２３５Ｑ１２３６、−Ｓ（Ｏ₂）Ｏ−Ｑ１２３７、−Ｐ（Ｏ）（ＯＱ１２３８）（ＯＱ１２３９）、−Ｓｉ（Ｑ１２４０）（Ｑ１２４１）（Ｑ１２４２）"；
その際、Ｑ１１９１、Ｑ１１９２、Ｑ１１９３、Ｑ１１９４、Ｑ１１９５、Ｑ１１９６、Ｑ１１９７、Ｑ１１９８、Ｑ１１９９、Ｑ１２００、Ｑ１２０１、Ｑ１２０２、Ｑ１２０３、Ｑ１２０４、Ｑ１２０５、Ｑ１２０６、Ｑ１２０７、Ｑ１２０８、Ｑ１２０９、Ｑ１２１０、Ｑ１２１１、Ｑ１２１２、Ｑ１２１３、Ｑ１２１４、Ｑ１２１５、Ｑ１２１６、Ｑ１２１７、Ｑ１２１８、Ｑ１２１９、Ｑ１２２０、Ｑ１２２１、Ｑ１２２２、Ｑ１２２３、Ｑ１２２４、Ｑ１２２５、Ｑ１２２６、Ｑ１２２７、Ｑ１２２８、Ｑ１２２９、Ｑ１２３０、Ｑ１２３１、Ｑ１２３２、Ｑ１２３３、Ｑ１２３４、Ｑ１２３５、Ｑ１２３６、Ｑ１２３７、Ｑ１２３８、Ｑ１２３９、Ｑ１２４０、Ｑ１２４１、Ｑ１２４２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＱ１１９７、Ｑ１１９８及び／又はＱ１２０６、Ｑ１２０７及び／又はＱ１２１９、Ｑ１２２０及び／又はＱ１２２６、Ｑ１２２７及び／又はＱ１２３５、Ｑ１２３６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ１、Ｚ２は、互いに無関係に、"水素、ＮＺ１４Ｚ１５"からなる群から選択される；
但し、Ｚ１＝１の場合に、Ｚ２＝ＮＺ１４Ｚ１５であり、かつＺ１＝ＮＺ１４Ｚ１５の場合に、Ｚ２＝Ｈである；
その際、Ｚ１４、Ｚ１５は、互いに無関係に、以下のものからなる群から選択される：
（ａ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｙ１）ＮＺ１６Ｚ１７、−Ｃ（＝ＮＺ１８）−Ｚ１９、−Ｃ（Ｙ２）ＮＺ２０−Ｙ３−Ｚ２１"；
但し、Ｚ１４、Ｚ１５は、同時に水素又は"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"ではない；
但し、更に、基Ｚ１４、Ｚ１５の一方は、水素又は"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"であり、それぞれもう一方の基Ｚ１４、Ｚ１５は、"−Ｃ（Ｙ１）ＮＺ１６Ｚ１７"、"−Ｃ（＝ＮＺ１８）−Ｚ１９"もしくは"−Ｃ（Ｙ２）ＮＺ２０−Ｙ３−Ｚ２１"である；
その際、Ｙ１、Ｙ２、Ｙ３は、互いに無関係に、"Ｏ、Ｓ、＝ＮＨ、＝ＮＺ２２"からなる群から選択される；
その際、Ｚ１６、Ｚ１７、Ｚ１８、Ｚ１９、Ｚ２０、Ｚ２１、Ｚ２２は、互いに無関係に、以下のものからなる群から選択される：
（１）水素；
（２）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、ヘテロシクリル、ヘテロシクリルアルキル"；
その際、置換基群（ａ）及び／又は置換基群（２）の前記置換基は、互いに無関係に、場合により、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ１、−ＮＵ２Ｕ３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ４、−Ｃ（Ｏ）Ｏ−Ｕ５、−Ｃ（Ｏ）ＮＨ−Ｕ６、−Ｃ（Ｏ）ＮＵ７Ｕ８、−Ｏ−Ｕ９、−Ｏ（−Ｕ１０−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｕ１１−Ｏ）_r−Ｕ１２（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ１３、−ＯＣ（Ｏ）−Ｏ−Ｕ１４、−ＯＣ（Ｏ）−ＮＨＵ１５、−Ｏ−Ｃ（Ｏ）−ＮＵ１６Ｕ１７、−ＯＰ（Ｏ）（ＯＵ１８）（ＯＵ１９）、−ＯＳｉ（Ｕ２０）（Ｕ２１）（Ｕ２２）、−ＯＳ（Ｏ₂）−Ｕ２３、−ＮＨＣ（Ｏ）−Ｕ２４、−ＮＵ２５Ｃ（Ｏ）−Ｕ２６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ２７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ２８、−ＮＨ−Ｃ（Ｏ）−ＮＵ２９Ｕ３０、−ＮＵ３１−Ｃ（Ｏ）−Ｏ−Ｕ３２、−ＮＵ３３−Ｃ（Ｏ）−ＮＨ−Ｕ３４、−ＮＵ３５−Ｃ（Ｏ）−ＮＵ３６Ｕ３７、−ＮＨＳ（Ｏ₂）−Ｕ３８、−ＮＵ３９Ｓ（Ｏ₂）−Ｕ４０、−Ｓ−Ｕ４１、−Ｓ（Ｏ）−Ｕ４２、−Ｓ（Ｏ₂）−Ｕ４３、−Ｓ（Ｏ₂）ＮＨ−Ｕ４４、−Ｓ（Ｏ₂）ＮＵ４５Ｕ４６、−Ｓ（Ｏ₂）Ｏ−Ｕ４７、−Ｐ（Ｏ）（ＯＵ４８）（ＯＵ４９）、−Ｓｉ（Ｕ５０）（Ｕ５１）（Ｕ５２）"；
その際、Ｕ１、Ｕ２、Ｕ３、Ｕ４、Ｕ５、Ｕ６、Ｕ７、Ｕ８、Ｕ９、Ｕ１０、Ｕ１１、Ｕ１２、Ｕ１３、Ｕ１４、Ｕ１５、Ｕ１６、Ｕ１７、Ｕ１８、Ｕ１９、Ｕ２０、Ｕ２１、Ｕ２２、Ｕ２３、Ｕ２４、Ｕ２５、Ｕ２６、Ｕ２７、Ｕ２８、Ｕ２９、Ｕ３０、Ｕ３１、Ｕ３２、Ｕ３３、Ｕ３４、Ｕ３５、Ｕ３６、Ｕ３７、Ｕ３８、Ｕ３９、Ｕ４０、Ｕ４１、Ｕ４２、Ｕ４３、Ｕ４４、Ｕ４５、Ｕ４６、Ｕ４７、Ｕ４８、Ｕ４９、Ｕ５０、Ｕ５１、Ｕ５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ７、Ｕ８及び／又はＵ１６、Ｕ１７及び／又はＵ２９、Ｕ３０及び／又はＵ３６、Ｕ３７及び／又はＵ４５、Ｕ４６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ５３、−ＮＵ５４Ｕ５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ５６、−Ｃ（Ｏ）Ｏ−Ｕ５７、−Ｃ（Ｏ）ＮＨ−Ｕ５８、−Ｃ（Ｏ）ＮＵ５９Ｕ６０、−Ｏ−Ｕ６１、−Ｏ（−Ｕ６２−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｕ６３−Ｏ）_r−Ｕ６４（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ６５、−ＯＣ（Ｏ）−Ｏ−Ｕ６６、−ＯＣ（Ｏ）−ＮＨＵ６７、−Ｏ−Ｃ（Ｏ）−ＮＵ６８Ｕ６９、−ＯＰ（Ｏ）（ＯＵ７０）（ＯＵ７１）、−ＯＳｉ（Ｕ７２）（Ｕ７３）（Ｕ７４）、−ＯＳ（Ｏ₂）−Ｕ７５、−ＮＨＣ（Ｏ）−Ｕ７６、−ＮＵ７７Ｃ（Ｏ）−Ｕ７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ８０、−ＮＨ−Ｃ（Ｏ）−ＮＵ８１Ｕ８２、−ＮＵ８３−Ｃ（Ｏ）−Ｏ−Ｕ８４、−ＮＵ８５−Ｃ（Ｏ）−ＮＨ−Ｕ８６、−ＮＵ８７−Ｃ（Ｏ）−ＮＵ８８Ｕ８９、−ＮＨＳ（Ｏ₂）−Ｕ９０、−ＮＵ９１Ｓ（Ｏ₂）−Ｕ９２、−Ｓ−Ｕ９３、−Ｓ（Ｏ）−Ｕ９４、−Ｓ（Ｏ₂）−Ｕ９５、−Ｓ（Ｏ₂）ＮＨ−Ｕ９６、−Ｓ（Ｏ₂）ＮＵ９７Ｕ９８、−Ｓ（Ｏ₂）Ｏ−Ｕ９９、−Ｐ（Ｏ）（ＯＵ１００）（ＯＵ１０１）、−Ｓｉ（Ｕ１０２）（Ｕ１０３）（Ｕ１０４）"；
その際、Ｕ５３、Ｕ５４、Ｕ５５、Ｕ５６、Ｕ５７、Ｕ５８、Ｕ５９、Ｕ６０、Ｕ６１、Ｕ６２、Ｕ６３、Ｕ６４、Ｕ６５、Ｕ６６、Ｕ６７、Ｕ６８、Ｕ６９、Ｕ７０、Ｕ７１、Ｕ７２、Ｕ７３、Ｕ７４、Ｕ７５、Ｕ７６、Ｕ７７、Ｕ７８、Ｕ７９、Ｕ８０、Ｕ８１、Ｕ８２、Ｕ８３、Ｕ８４、Ｕ８５、Ｕ８６、Ｕ８７、Ｕ８８、Ｕ８９、Ｕ９０、Ｕ９１、Ｕ９２、Ｕ９３、Ｕ９４、Ｕ９５、Ｕ９６、Ｕ９７、Ｕ９８、Ｕ９９、Ｕ１００、Ｕ１０１、Ｕ１０２、Ｕ１０３、Ｕ１０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ５９、Ｕ６０及び／又はＵ６８、Ｕ６９及び／又はＵ８１、Ｕ８２及び／又はＵ８８、Ｕ８９及び／又はＵ９７、Ｕ９８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ１０５、−ＮＵ１０６Ｕ１０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ１０８、−Ｃ（Ｏ）Ｏ−Ｕ１０９、−Ｃ（Ｏ）ＮＨ−Ｕ１１０、−Ｃ（Ｏ）ＮＵ１１１Ｕ１１２、−Ｏ−Ｕ１１３、−Ｏ（−Ｕ１１４−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ｕ１１５−Ｏ）_s−Ｕ１１６（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ１１７、−ＯＣ（Ｏ）−Ｏ−Ｕ１１８、−ＯＣ（Ｏ）−ＮＨＵ１１９、−Ｏ−Ｃ（Ｏ）−ＮＵ１２０Ｕ１２１、−ＯＰ（Ｏ）（ＯＵ１２２）（ＯＵ１２３）、−ＯＳｉ（Ｕ１２４）（Ｕ１２５）（Ｕ１２６）、−ＯＳ（Ｏ₂）−Ｕ１２７、−ＮＨＣ（Ｏ）−Ｕ１２８、−ＮＵ１２９Ｃ（Ｏ）−Ｕ１３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ１３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ１３２、−ＮＨ−Ｃ（Ｏ）−ＮＵ１３３Ｕ１３４、−ＮＵ１３５−Ｃ（Ｏ）−Ｏ−Ｕ１３６、−ＮＵ１３７−Ｃ（Ｏ）−ＮＨ−Ｕ１３８、−ＮＵ１３９−Ｃ（Ｏ）−ＮＵ１４０Ｕ１４１、−ＮＨＳ（Ｏ₂）−Ｕ１４２、−ＮＵ１４３Ｓ（Ｏ₂）−Ｕ１４４、−Ｓ−Ｕ１４５、−Ｓ（Ｏ）−Ｕ１４６、−Ｓ（Ｏ₂）−Ｕ１４７、−Ｓ（Ｏ₂）ＮＨ−Ｕ１４８、−Ｓ（Ｏ₂）ＮＵ１４９Ｕ１５０、−Ｓ（Ｏ₂）Ｏ−Ｕ１５１、−Ｐ（Ｏ）（ＯＵ１５２）（ＯＵ１５３）、−Ｓｉ（Ｕ１５４）（Ｕ１５５）（Ｕ１５６）"；
その際、Ｕ１０５、Ｕ１０６、Ｕ１０７、Ｕ１０８、Ｕ１０９、Ｕ１１０、Ｕ１１１、Ｕ１１２、Ｕ１１３、Ｕ１１４、Ｕ１１５、Ｕ１１６、Ｕ１１７、Ｕ１１８、Ｕ１１９、Ｕ１２０、Ｕ１２１、Ｕ１２２、Ｕ１２３、Ｕ１２４、Ｕ１２５、Ｕ１２６、Ｕ１２７、Ｕ１２８、Ｕ１２９、Ｕ１３０、Ｕ１３１、Ｕ１３２、Ｕ１３３、Ｕ１３４、Ｕ１３５、Ｕ１３６、Ｕ１３７、Ｕ１３８、Ｕ１３９、Ｕ１４０、Ｕ１４１、Ｕ１４２、Ｕ１４３、Ｕ１４４、Ｕ１４５、Ｕ１４６、Ｕ１４７、Ｕ１４８、Ｕ１４９、Ｕ１５０、Ｕ１５１、Ｕ１５２、Ｕ１５３、Ｕ１５４、Ｕ１５５、Ｕ１５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ１１１、Ｕ１１２及び／又はＵ１２０、Ｕ１２１及び／又はＵ１３３、Ｕ１３４及び／又はＵ１４０、Ｕ１４１及び／又はＵ１４９、Ｕ１５０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（３）−Ｃ（Ｏ）−Ｚ２３、
その際、Ｚ２３は、無関係に、以下のものからなる群から選択される：
（ａ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、置換基群（ａ）の前記置換基は、互いに無関係に、場合により、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ１５７、−ＮＵ１５８Ｕ１５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ１６０、−Ｃ（Ｏ）Ｏ−Ｕ１６１、−Ｃ（Ｏ）ＮＨ−Ｕ１６２、−Ｃ（Ｏ）ＮＵ１６３Ｕ１６４、−Ｏ−Ｕ１６５、−Ｏ（−Ｕ１６６−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｕ１６７−Ｏ）_t−Ｕ１６８（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ１６９、−ＯＣ（Ｏ）−Ｏ−Ｕ１７０、−ＯＣ（Ｏ）−ＮＨＵ１７１、−Ｏ−Ｃ（Ｏ）−ＮＵ１７２Ｕ１７３、−ＯＰ（Ｏ）（ＯＵ１７４）（ＯＵ１７５）、−ＯＳｉ（Ｕ１７６）（Ｕ１７７）（Ｕ１７８）、−ＯＳ（Ｏ₂）−Ｕ１７９、−ＮＨＣ（Ｏ）−Ｕ１８０、−ＮＵ１８１Ｃ（Ｏ）−Ｕ１８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ１８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ１８４、−ＮＨ−Ｃ（Ｏ）−ＮＵ１８５Ｕ１８６、−ＮＵ１８７−Ｃ（Ｏ）−Ｏ−Ｕ１８８、−ＮＵ１８９−Ｃ（Ｏ）−ＮＨ−Ｕ１９０、−ＮＵ１９１−Ｃ（Ｏ）−ＮＵ１９２Ｕ１９３、−ＮＨＳ（Ｏ₂）−Ｕ１９４、−ＮＵ１９５Ｓ（Ｏ₂）−Ｕ１９６、−Ｓ−Ｕ１９７、−Ｓ（Ｏ）−Ｕ１９８、−Ｓ（Ｏ₂）−Ｕ１９９、−Ｓ（Ｏ₂）ＮＨ−Ｕ２００、−Ｓ（Ｏ₂）ＮＵ２０１Ｕ２０２、−Ｓ（Ｏ₂）Ｏ−Ｕ２０３、−Ｐ（Ｏ）（ＯＵ２０４）（ＯＵ２０５）、−Ｓｉ（Ｕ２０６）（Ｕ２０７）（Ｕ２０８）"；
その際、Ｕ１５７、Ｕ１５８、Ｕ１５９、Ｕ１６０、Ｕ１６１、Ｕ１６２、Ｕ１６３、Ｕ１６４、Ｕ１６５、Ｕ１６６、Ｕ１６７、Ｕ１６８、Ｕ１６９、Ｕ１７０、Ｕ１７１、Ｕ１７２、Ｕ１７３、Ｕ１７４、Ｕ１７５、Ｕ１７６、Ｕ１７７、Ｕ１７８、Ｕ１７９、Ｕ１８０、Ｕ１８１、Ｕ１８２、Ｕ１８３、Ｕ１８４、Ｕ１８５、Ｕ１８６、Ｕ１８７、Ｕ１８８、Ｕ１８９、Ｕ１９０、Ｕ１９１、Ｕ１９２、Ｕ１９３、Ｕ１９４、Ｕ１９５、Ｕ１９６、Ｕ１９７、Ｕ１９８、Ｕ１９９、Ｕ２００、Ｕ２０１、Ｕ２０２、Ｕ２０３、Ｕ２０４、Ｕ２０５、Ｕ２０６、Ｕ２０７、Ｕ２０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ１６３、Ｕ１６４及び／又はＵ１７２、Ｕ１７３及び／又はＵ１８５、Ｕ１８６及び／又はＵ１９２、Ｕ１９３及び／又はＵ２０１、Ｕ２０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ２０９、−ＮＵ２１０Ｕ２１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ２１２、−Ｃ（Ｏ）Ｏ−Ｕ２１３、−Ｃ（Ｏ）ＮＨ−Ｕ２１４、−Ｃ（Ｏ）ＮＵ２１５Ｕ２１６、−Ｏ−Ｕ２１７、−Ｏ（−Ｕ２１８−Ｏ）_u−Ｈ（ｕ＝１、２、３、４、５）、−Ｏ（−Ｕ２１９−Ｏ）_u−Ｕ２２０（ｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ２２１、−ＯＣ（Ｏ）−Ｏ−Ｕ２２２、−ＯＣ（Ｏ）−ＮＨＵ２２３、−Ｏ−Ｃ（Ｏ）−ＮＵ２２４Ｕ２２５、−ＯＰ（Ｏ）（ＯＵ２２６）（ＯＵ２２７）、−ＯＳｉ（Ｕ２２８）（Ｕ２２９）（Ｕ２３０）、−ＯＳ（Ｏ₂）−Ｕ２３１、−ＮＨＣ（Ｏ）−Ｕ２３２、−ＮＵ２３３Ｃ（Ｏ）−Ｕ２３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ２３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ２３６、−ＮＨ−Ｃ（Ｏ）−ＮＵ２３７Ｕ２３８、−ＮＵ２３９−Ｃ（Ｏ）−Ｏ−Ｕ２４０、−ＮＵ２４１−Ｃ（Ｏ）−ＮＨ−Ｕ２４２、−ＮＵ２４３−Ｃ（Ｏ）−ＮＵ２４４Ｕ２４５、−ＮＨＳ（Ｏ₂）−Ｕ２４６、−ＮＵ２４７Ｓ（Ｏ₂）−Ｕ２４８、−Ｓ−Ｕ２４９、−Ｓ（Ｏ）−Ｕ２５０、−Ｓ（Ｏ₂）−Ｕ２５１、−Ｓ（Ｏ₂）ＮＨ−Ｕ２５２、−Ｓ（Ｏ₂）ＮＵ２５３Ｕ２５４、−Ｓ（Ｏ₂）Ｏ−Ｕ２５５、−Ｐ（Ｏ）（ＯＵ２５６）（ＯＵ２５７）、−Ｓｉ（Ｕ２５８）（Ｕ２５９）（Ｕ２６０）"；
その際、Ｕ２０９、Ｕ２１０、Ｕ２１１、Ｕ２１２、Ｕ２１３、Ｕ２１４、Ｕ２１５、Ｕ２１６、Ｕ２１７、Ｕ２１８、Ｕ２１９、Ｕ２２０、Ｕ２２１、Ｕ２２２、Ｕ２２３、Ｕ２２４、Ｕ２２５、Ｕ２２６、Ｕ２２７、Ｕ２２８、Ｕ２２９、Ｕ２３０、Ｕ２３１、Ｕ２３２、Ｕ２３３、Ｕ２３４、Ｕ２３５、Ｕ２３６、Ｕ２３７、Ｕ２３８、Ｕ２３９、Ｕ２４０、Ｕ２４１、Ｕ２４２、Ｕ２４３、Ｕ２４４、Ｕ２４５、Ｕ２４６、Ｕ２４７、Ｕ２４８、Ｕ２４９、Ｕ２５０、Ｕ２５１、Ｕ２５２、Ｕ２５３、Ｕ２５４、Ｕ２５５、Ｕ２５６、Ｕ２５７、Ｕ２５８、Ｕ２５９、Ｕ２６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ２１５、Ｕ２１６及び／又はＵ２２４、Ｕ２２５及び／又はＵ２３７、Ｕ２３８及び／又はＵ２４４、Ｕ２４５及び／又はＵ２５３、Ｕ２５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ２６１、−ＮＵ２６２Ｕ２６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ２６４、−Ｃ（Ｏ）Ｏ−Ｕ２６５、−Ｃ（Ｏ）ＮＨ−Ｕ２６６、−Ｃ（Ｏ）ＮＵ２６７Ｕ２６８、−Ｏ−Ｕ２６９、−Ｏ（−Ｕ２７０−Ｏ）_v−Ｈ（ｖ＝１、２、３、４、５）、−Ｏ（−Ｕ２７１−Ｏ）_v−Ｕ２７２（ｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ２７３、−ＯＣ（Ｏ）−Ｏ−Ｕ２７４、−ＯＣ（Ｏ）−ＮＨＵ２７５、−Ｏ−Ｃ（Ｏ）−ＮＵ２７６Ｕ２７７、−ＯＰ（Ｏ）（ＯＵ２７８）（ＯＵ２７９）、−ＯＳｉ（Ｕ２８０）（Ｕ２８１）（Ｕ２８２）、−ＯＳ（Ｏ₂）−Ｕ２８３、−ＮＨＣ（Ｏ）−Ｕ２８４、−ＮＵ２８５Ｃ（Ｏ）−Ｕ２８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ２８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ２８８、−ＮＨ−Ｃ（Ｏ）−ＮＵ２８９Ｕ２９０、−ＮＵ２９１−Ｃ（Ｏ）−Ｏ−Ｕ２９２、−ＮＵ２９３−Ｃ（Ｏ）−ＮＨ−Ｕ２９４、−ＮＵ２９５−Ｃ（Ｏ）−ＮＵ２９６Ｕ２９７、−ＮＨＳ（Ｏ₂）−Ｕ２９８、−ＮＵ２９９Ｓ（Ｏ₂）−Ｕ３００、−Ｓ−Ｕ３０１、−Ｓ（Ｏ）−Ｕ３０２、−Ｓ（Ｏ₂）−Ｕ３０３、−Ｓ（Ｏ₂）ＮＨ−Ｕ３０４、−Ｓ（Ｏ₂）ＮＵ３０５Ｕ３０６、−Ｓ（Ｏ₂）Ｏ−Ｕ３０７、−Ｐ（Ｏ）（ＯＵ３０８）（ＯＵ３０９）、−Ｓｉ（Ｕ３１０）（Ｕ３１１）（Ｕ３１２）"；
その際、Ｕ２６１、Ｕ２６２、Ｕ２６３、Ｕ２６４、Ｕ２６５、Ｕ２６６、Ｕ２６７、Ｕ２６８、Ｕ２６９、Ｕ２７０、Ｕ２７１、Ｕ２７２、Ｕ２７３、Ｕ２７４、Ｕ２７５、Ｕ２７６、Ｕ２７７、Ｕ２７８、Ｕ２７９、Ｕ２８０、Ｕ２８１、Ｕ２８２、Ｕ２８３、Ｕ２８４、Ｕ２８５、Ｕ２８６、Ｕ２８７、Ｕ２８８、Ｕ２８９、Ｕ２９０、Ｕ２９１、Ｕ２９２、Ｕ２９３、Ｕ２９４、Ｕ２９５、Ｕ２９６、Ｕ２９７、Ｕ２９８、Ｕ２９９、Ｕ３００、Ｕ３０１、Ｕ３０２、Ｕ３０３、Ｕ３０４、Ｕ３０５、Ｕ３０６、Ｕ３０７、Ｕ３０８、Ｕ３０９、Ｕ３１０、Ｕ３１１、Ｕ３１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ２６７、Ｕ２６８及び／又はＵ２７６、Ｕ２７７及び／又はＵ２８９、Ｕ２９０及び／又はＵ２９６、Ｕ２９７及び／又はＵ３０５、Ｕ３０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（４）Ｚ１６、Ｚ１７は、無関係に、場合により、一緒になって、"ヘテロシクリル"を形成することもできる；
（５）"−Ｃ（Ｏ）−Ｃ（Ｏ）−Ｕ３１３、−Ｓ（Ｏ₂）−ＮＵ３１４Ｕ３１５"；
その際、Ｕ３１３、Ｕ３１４、Ｕ３１５は、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ３１６、−ＮＵ３１７Ｕ３１８、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ３１９、−Ｃ（Ｏ）Ｏ−Ｕ３２０、−Ｃ（Ｏ）ＮＨ−Ｕ３２１、−Ｃ（Ｏ）ＮＵ３２２Ｕ３２３、−Ｏ−Ｕ３２４、−Ｏ（−Ｕ３２５−Ｏ）_w−Ｈ（ｗ＝１、２、３、４、５）、−Ｏ（−Ｕ３２６−Ｏ）_w−Ｕ３２７（ｗ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ３２８、−ＯＣ（Ｏ）−Ｏ−Ｕ３２９、−ＯＣ（Ｏ）−ＮＨＵ３３０、−Ｏ−Ｃ（Ｏ）−ＮＵ３３１Ｕ３３２、−ＯＰ（Ｏ）（ＯＵ３３３）（ＯＵ３３４）、−ＯＳｉ（Ｕ３３５）（Ｕ３３６）（Ｕ３３７）、−ＯＳ（Ｏ₂）−Ｕ３３８、−ＮＨＣ（Ｏ）−Ｕ３３９、−ＮＵ３４０Ｃ（Ｏ）−Ｕ３４１、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ３４２、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ３４３、−ＮＨ−Ｃ（Ｏ）−ＮＵ３４４Ｕ３４５、−ＮＵ３４６−Ｃ（Ｏ）−Ｏ−Ｕ３４７、−ＮＵ３４８−Ｃ（Ｏ）−ＮＨ−Ｕ３４９、−ＮＵ３５０−Ｃ（Ｏ）−ＮＵ３５１Ｕ３５２、−ＮＨＳ（Ｏ₂）−Ｕ３５３、−ＮＵ３５４Ｓ（Ｏ₂）−Ｕ３５５、−Ｓ−Ｕ３５６、−Ｓ（Ｏ）−Ｕ３５７、−Ｓ（Ｏ₂）−Ｕ３５８、−Ｓ（Ｏ₂）ＮＨ−Ｕ３５９、−Ｓ（Ｏ₂）ＮＵ３６０Ｕ３６１、−Ｓ（Ｏ₂）Ｏ−Ｕ３６２、−Ｐ（Ｏ）（ＯＵ３６３）（ＯＵ３６４）、−Ｓｉ（Ｕ３６５）（Ｕ３６６）（Ｕ３６７）"；
その際、Ｕ３１６、Ｕ３１７、Ｕ３１８、Ｕ３１９、Ｕ３２０、Ｕ３２１、Ｕ３２２、Ｕ３２３、Ｕ３２４、Ｕ３２５、Ｕ３２６、Ｕ３２７、Ｕ３２８、Ｕ３２９、Ｕ３３０、Ｕ３３１、Ｕ３３２、Ｕ３３３、Ｕ３３４、Ｕ３３５、Ｕ３３６、Ｕ３３７、Ｕ３３８、Ｕ３３９、Ｕ３４０、Ｕ３４１、Ｕ３４２、Ｕ３４３、Ｕ３４４、Ｕ３４５、Ｕ３４６、Ｕ３４７、Ｕ３４８、Ｕ３４９、Ｕ３５０、Ｕ３５１、Ｕ３５２、Ｕ３５３、Ｕ３５４、Ｕ３５５、Ｕ３５６、Ｕ３５７、Ｕ３５８、Ｕ３５９、Ｕ３６０、Ｕ３６１、Ｕ３６２、Ｕ３６３、Ｕ３６４、Ｕ３６５、Ｕ３６６、Ｕ３６７は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ３２２、Ｕ３２３及び／又はＵ３３１、Ｕ３３２及び／又はＵ３４４、Ｕ３４５及び／又はＵ３５１、Ｕ３５２及び／又はＵ３６０、Ｕ３６１は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（Ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ３６８、−ＮＵ３６９Ｕ３７０、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ３７１、−Ｃ（Ｏ）Ｏ−Ｕ３７２、−Ｃ（Ｏ）ＮＨ−Ｕ３７３、−Ｃ（Ｏ）ＮＵ３７４Ｕ３７５、−Ｏ−Ｕ３７６、−Ｏ（−Ｕ３７７−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−Ｏ（−Ｕ３７８−Ｏ）_x−Ｕ３７９（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ３８０、−ＯＣ（Ｏ）−Ｏ−Ｕ３８１、−ＯＣ（Ｏ）−ＮＨＵ３８２、−Ｏ−Ｃ（Ｏ）−ＮＵ３８３Ｕ３８４、−ＯＰ（Ｏ）（ＯＵ３８５）（ＯＵ３８６）、−ＯＳｉ（Ｕ３８７）（Ｕ３８８）（Ｕ３８９）、−ＯＳ（Ｏ₂）−Ｕ３９０、−ＮＨＣ（Ｏ）−Ｕ３９１、−ＮＵ３９２Ｃ（Ｏ）−Ｕ３９３、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ３９４、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ３９５、−ＮＨ−Ｃ（Ｏ）−ＮＵ３９６Ｕ３９７、−ＮＵ３９８−Ｃ（Ｏ）−Ｏ−Ｕ３９９、−ＮＵ４００−Ｃ（Ｏ）−ＮＨ−Ｕ４０１、−ＮＵ４０２−Ｃ（Ｏ）−ＮＵ４０３Ｕ４０４、−ＮＨＳ（Ｏ₂）−Ｕ４０５、−ＮＵ４０６Ｓ（Ｏ₂）−Ｕ４０７、−Ｓ−Ｕ４０８、−Ｓ（Ｏ）−Ｕ４０９、−Ｓ（Ｏ₂）−Ｕ４１０、−Ｓ（Ｏ₂）ＮＨ−Ｕ４１１、−Ｓ（Ｏ₂）ＮＵ４１２Ｕ４１３、−Ｓ（Ｏ₂）Ｏ−Ｕ４１４、−Ｐ（Ｏ）（ＯＵ４１５）（ＯＵ４１６）、−Ｓｉ（Ｕ４１７）（Ｕ４１８）（Ｕ４１９）"；
その際、Ｕ３６８、Ｕ３６９、Ｕ３７０、Ｕ３７１、Ｕ３７２、Ｕ３７３、Ｕ３７４、Ｕ３７５、Ｕ３７６、Ｕ３７７、Ｕ３７８、Ｕ３７９、Ｕ３８０、Ｕ３８１、Ｕ３８２、Ｕ３８３、Ｕ３８４、Ｕ３８５、Ｕ３８６、Ｕ３８７、Ｕ３８８、Ｕ３８９、Ｕ３９０、Ｕ３９１、Ｕ３９２、Ｕ３９３、Ｕ３９４、Ｕ３９５、Ｕ３９６、Ｕ３９７、Ｕ３９８、Ｕ３９９、Ｕ４００、Ｕ４０１、Ｕ４０２、Ｕ４０３、Ｕ４０４、Ｕ４０５、Ｕ４０６、Ｕ４０７、Ｕ４０８、Ｕ４０９、Ｕ４１０、Ｕ４１１、Ｕ４１２、Ｕ４１３、Ｕ４１４、Ｕ４１５、Ｕ４１６、Ｕ４１７、Ｕ４１８、Ｕ４１９は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ３７４、Ｕ３７５及び／又はＵ３８３、Ｕ３８４及び／又はＵ３９６、Ｕ３９７及び／又はＵ４０３、Ｕ４０４及び／又はＵ４１２、Ｕ４１３は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ４２０、−ＮＵ４２１Ｕ４２２、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ４２３、−Ｃ（Ｏ）Ｏ−Ｕ４２４、−Ｃ（Ｏ）ＮＨ−Ｕ４２５、−Ｃ（Ｏ）ＮＵ４２６Ｕ４２７、−Ｏ−Ｕ４２８、−Ｏ（−Ｕ４２９−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｕ４３０−Ｏ）_y−Ｕ４３１（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ４３２、−ＯＣ（Ｏ）−Ｏ−Ｕ４３３、−ＯＣ（Ｏ）−ＮＨＵ４３４、−Ｏ−Ｃ（Ｏ）−ＮＵ４３５Ｕ４３６、−ＯＰ（Ｏ）（ＯＵ４３７）（ＯＵ４３８）、−ＯＳｉ（Ｕ４３９）（Ｕ４４０）（Ｕ４４１）、−ＯＳ（Ｏ₂）−Ｕ４４２、−ＮＨＣ（Ｏ）−Ｕ４４３、−ＮＵ４４４Ｃ（Ｏ）−Ｕ４４５、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ４４６、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ４４７、−ＮＨ−Ｃ（Ｏ）−ＮＵ４４８Ｕ４４９、−ＮＵ４５０−Ｃ（Ｏ）−Ｏ−Ｕ４５１、−ＮＵ４５２−Ｃ（Ｏ）−ＮＨ−Ｕ４５３、−ＮＵ４５４−Ｃ（Ｏ）−ＮＵ４５５Ｕ４５６、−ＮＨＳ（Ｏ₂）−Ｕ４５７、−ＮＵ４５８Ｓ（Ｏ₂）−Ｕ４５９、−Ｓ−Ｕ４６０、−Ｓ（Ｏ）−Ｕ４６１、−Ｓ（Ｏ₂）−Ｕ４６２、−Ｓ（Ｏ₂）ＮＨ−Ｕ４６３、−Ｓ（Ｏ₂）ＮＵ４６４Ｕ４６５、−Ｓ（Ｏ₂）Ｏ−Ｕ４６６、−Ｐ（Ｏ）（ＯＵ４６７）（ＯＵ４６８）、−Ｓｉ（Ｕ４６９）（Ｕ４７０）（Ｕ４７１）"；
その際、Ｕ４２０、Ｕ４２１、Ｕ４２２、Ｕ４２３、Ｕ４２４、Ｕ４２５、Ｕ４２６、Ｕ４２７、Ｕ４２８、Ｕ４２９、Ｕ４３０、Ｕ４３１、Ｕ４３２、Ｕ４３３、Ｕ４３４、Ｕ４３５、Ｕ４３６、Ｕ４３７、Ｕ４３８、Ｕ４３９、Ｕ４４０、Ｕ４４１、Ｕ４４２、Ｕ４４３、Ｕ４４４、Ｕ４４５、Ｕ４４６、Ｕ４４７、Ｕ４４８、Ｕ４４９、Ｕ４５０、Ｕ４５１、Ｕ４５２、Ｕ４５３、Ｕ４５４、Ｕ４５５、Ｕ４５６、Ｕ４５７、Ｕ４５８、Ｕ４５９、Ｕ４６０、Ｕ４６１、Ｕ４６２、Ｕ４６３、Ｕ４６４、Ｕ４６５、Ｕ４６６、Ｕ４６７、Ｕ４６８、Ｕ４６９、Ｕ４７０、Ｕ４７１は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ４２６、Ｕ４２７及び／又はＵ４３５、Ｕ４３６及び／又はＵ４４８、Ｕ４４９及び／又はＵ４５５、Ｕ４５６及び／又はＵ４６４、Ｕ４６５は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＵ４７２、−ＮＵ４７３Ｕ４７４、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｕ４７５、−Ｃ（Ｏ）Ｏ−Ｕ４７６、−Ｃ（Ｏ）ＮＨ−Ｕ４７７、−Ｃ（Ｏ）ＮＵ４７８Ｕ４７９、−Ｏ−Ｕ４８０、−Ｏ（−Ｕ４８１−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｕ４８２−Ｏ）_z−Ｕ４８３（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｕ４８４、−ＯＣ（Ｏ）−Ｏ−Ｕ４８５、−ＯＣ（Ｏ）−ＮＨＵ４８６、−Ｏ−Ｃ（Ｏ）−ＮＵ４８７Ｕ４８８、−ＯＰ（Ｏ）（ＯＵ４８９）（ＯＵ４９０）、−ＯＳｉ（Ｕ４９１）（Ｕ４９２）（Ｕ４９３）、−ＯＳ（Ｏ₂）−Ｕ４９４、−ＮＨＣ（Ｏ）−Ｕ４９５、−ＮＵ４９６Ｃ（Ｏ）−Ｕ４９７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｕ４９８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｕ４９９、−ＮＨ−Ｃ（Ｏ）−ＮＵ５００Ｕ５０１、−ＮＵ５０２−Ｃ（Ｏ）−Ｏ−Ｕ５０３、−ＮＵ５０４−Ｃ（Ｏ）−ＮＨ−Ｕ５０５、−ＮＵ５０６−Ｃ（Ｏ）−ＮＵ５０７Ｕ５０８、−ＮＨＳ（Ｏ₂）−Ｕ５０９、−ＮＵ５１０Ｓ（Ｏ₂）−Ｕ５１１、−Ｓ−Ｕ５１２、−Ｓ（Ｏ）−Ｕ５１３、−Ｓ（Ｏ₂）−Ｕ５１４、−Ｓ（Ｏ₂）ＮＨ−Ｕ５１５、−Ｓ（Ｏ₂）ＮＵ５１６Ｕ５１７、−Ｓ（Ｏ₂）Ｏ−Ｕ５１８、−Ｐ（Ｏ）（ＯＵ５１９）（ＯＵ５２０）、−Ｓｉ（Ｕ５２１）（Ｕ５２２）（Ｕ５２３）"；
その際、Ｕ４７２、Ｕ４７３、Ｕ４７４、Ｕ４７５、Ｕ４７６、Ｕ４７７、Ｕ４７８、Ｕ４７９、Ｕ４８０、Ｕ４８１、Ｕ４８２、Ｕ４８３、Ｕ４８４、Ｕ４８５、Ｕ４８６、Ｕ４８７、Ｕ４８８、Ｕ４８９、Ｕ４９０、Ｕ４９１、Ｕ４９２、Ｕ４９３、Ｕ４９４、Ｕ４９５、Ｕ４９６、Ｕ４９７、Ｕ４９８、Ｕ４９９、Ｕ５００、Ｕ５０１、Ｕ５０２、Ｕ５０３、Ｕ５０４、Ｕ５０５、Ｕ５０６、Ｕ５０７、Ｕ５０８、Ｕ５０９、Ｕ５１０、Ｕ５１１、Ｕ５１２、Ｕ５１３、Ｕ５１４、Ｕ５１５、Ｕ５１６、Ｕ５１７、Ｕ５１８、Ｕ５１９、Ｕ５２０、Ｕ５２１、Ｕ５２２、Ｕ５２３は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＵ４７８、Ｕ４７９及び／又はＵ４８７、Ｕ４８８及び／又はＵ５００、Ｕ５０１及び／又はＵ５０７、Ｕ５０８及び／又はＵ５１６、Ｕ５１７は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、選択的に、Ｕ３１４、Ｕ３１５は、一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ５は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＡ１、−ＮＡ２Ａ３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ａ４、−Ｃ（Ｏ）Ｏ−Ａ５、−Ｃ（Ｏ）ＮＨ−Ａ６、−Ｃ（Ｏ）ＮＡ７Ａ８、−Ｏ−Ａ９、−Ｏ（−Ａ１０−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ａ１１−Ｏ）_r−Ａ１２（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ａ１３、−ＯＣ（Ｏ）−Ｏ−Ａ１４、−ＯＣ（Ｏ）−ＮＨＡ１５、−Ｏ−Ｃ（Ｏ）−ＮＡ１６Ａ１７、−ＯＰ（Ｏ）（ＯＡ１８）（ＯＡ１９）、−ＯＳｉ（Ａ２０）（Ａ２１）（Ａ２２）、−ＯＳ（Ｏ₂）−Ａ２３、−ＮＨＣ（Ｏ）−Ａ２４、−ＮＡ２５Ｃ（Ｏ）−Ａ２６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ａ２７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ａ２８、−ＮＨ−Ｃ（Ｏ）−ＮＡ２９Ａ３０、−ＮＡ３１−Ｃ（Ｏ）−Ｏ−Ａ３２、−ＮＡ３３−Ｃ（Ｏ）−ＮＨ−Ａ３４、−ＮＡ３５−Ｃ（Ｏ）−ＮＡ３６Ａ３７、−ＮＨＳ（Ｏ₂）−Ａ３８、−ＮＡ３９Ｓ（Ｏ₂）−Ａ４０、−Ｓ−Ａ４１、−Ｓ（Ｏ）−Ａ４２、−Ｓ（Ｏ₂）−Ａ４３、−Ｓ（Ｏ₂）ＮＨ−Ａ４４、−Ｓ（Ｏ₂）ＮＡ４５Ａ４６、−Ｓ（Ｏ₂）Ｏ−Ａ４７、−Ｐ（Ｏ）（ＯＡ４８）（ＯＡ４９）、−Ｓｉ（Ａ５０）（Ａ５１）（Ａ５２）"；
その際、Ａ１、Ａ２、Ａ３、Ａ４、Ａ５、Ａ６、Ａ７、Ａ８、Ａ９、Ａ１０、Ａ１１、Ａ１２、Ａ１３、Ａ１４、Ａ１５、Ａ１６、Ａ１７、Ａ１８、Ａ１９、Ａ２０、Ａ２１、Ａ２２、Ａ２３、Ａ２４、Ａ２５、Ａ２６、Ａ２７、Ａ２８、Ａ２９、Ａ３０、Ａ３１、Ａ３２、Ａ３３、Ａ３４、Ａ３５、Ａ３６、Ａ３７、Ａ３８、Ａ３９、Ａ４０、Ａ４１、Ａ４２、Ａ４３、Ａ４４、Ａ４５、Ａ４６、Ａ４７、Ａ４８、Ａ４９、Ａ５０、Ａ５１、Ａ５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＡ７、Ａ８及び／又はＡ１６、Ａ１７及び／又はＡ２９、Ａ３０及び／又はＡ３６、Ａ３７及び／又はＡ４５、Ａ４６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＡ５３、−ＮＡ５４Ａ５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ａ５６、−Ｃ（Ｏ）Ｏ−Ａ５７、−Ｃ（Ｏ）ＮＨ−Ａ５８、−Ｃ（Ｏ）ＮＡ５９Ａ６０、−Ｏ−Ａ６１、−Ｏ（−Ａ６２−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ａ６３−Ｏ）_s−Ａ６４（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ａ６５、−ＯＣ（Ｏ）−Ｏ−Ａ６６、−ＯＣ（Ｏ）−ＮＨＡ６７、−Ｏ−Ｃ（Ｏ）−ＮＡ６８Ａ６９、−ＯＰ（Ｏ）（ＯＡ７０）（ＯＡ７１）、−ＯＳｉ（Ａ７２）（Ａ７３）（Ａ７４）、−ＯＳ（Ｏ₂）−Ａ７５、−ＮＨＣ（Ｏ）−Ａ７６、−ＮＡ７７Ｃ（Ｏ）−Ａ７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ａ７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ａ８０、−ＮＨ−Ｃ（Ｏ）−ＮＡ８１Ａ８２、−ＮＡ８３−Ｃ（Ｏ）−Ｏ−Ａ８４、−ＮＡ８５−Ｃ（Ｏ）−ＮＨ−Ａ８６、−ＮＡ８７−Ｃ（Ｏ）−ＮＡ８８Ａ８９、−ＮＨＳ（Ｏ₂）−Ａ９０、−ＮＡ９１Ｓ（Ｏ₂）−Ａ９２、−Ｓ−Ａ９３、−Ｓ（Ｏ）−Ａ９４、−Ｓ（Ｏ₂）−Ａ９５、−Ｓ（Ｏ₂）ＮＨ−Ａ９６、−Ｓ（Ｏ₂）ＮＡ９７Ａ９８、−Ｓ（Ｏ₂）Ｏ−Ａ９９、−Ｐ（Ｏ）（ＯＡ１００）（ＯＡ１０１）、−Ｓｉ（Ａ１０２）（Ａ１０３）（Ａ１０４）"；
その際、Ａ５３、Ａ５４、Ａ５５、Ａ５６、Ａ５７、Ａ５８、Ａ５９、Ａ６０、Ａ６１、Ａ６２、Ａ６３、Ａ６４、Ａ６５、Ａ６６、Ａ６７、Ａ６８、Ａ６９、Ａ７０、Ａ７１、Ａ７２、Ａ７３、Ａ７４、Ａ７５、Ａ７６、Ａ７７、Ａ７８、Ａ７９、Ａ８０、Ａ８１、Ａ８２、Ａ８３、Ａ８４、Ａ８５、Ａ８６、Ａ８７、Ａ８８、Ａ８９、Ａ９０、Ａ９１、Ａ９２、Ａ９３、Ａ９４、Ａ９５、Ａ９６、Ａ９７、Ａ９８、Ａ９９、Ａ１００、Ａ１０１、Ａ１０２、Ａ１０３、Ａ１０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＡ５９、Ａ６０及び／又はＡ６８、Ａ６９及び／又はＡ８１、Ａ８２及び／又はＡ８８、Ａ８９及び／又はＡ９７、Ａ９８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＡ１０５、−ＮＡ１０６Ａ１０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ａ１０８、−Ｃ（Ｏ）Ｏ−Ａ１０９、−Ｃ（Ｏ）ＮＨ−Ａ１１０、−Ｃ（Ｏ）ＮＡ１１１Ａ１１２、−Ｏ−Ａ１１３、−Ｏ（−Ａ１１４−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ａ１１５−Ｏ）_t−Ａ１１６（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ａ１１７、−ＯＣ（Ｏ）−Ｏ−Ａ１１８、−ＯＣ（Ｏ）−ＮＨＡ１１９、−Ｏ−Ｃ（Ｏ）−ＮＡ１２０Ａ１２１、−ＯＰ（Ｏ）（ＯＡ１２２）（ＯＡ１２３）、−ＯＳｉ（Ａ１２４）（Ａ１２５）（Ａ１２６）、−ＯＳ（Ｏ₂）−Ａ１２７、−ＮＨＣ（Ｏ）−Ａ１２８、−ＮＡ１２９Ｃ（Ｏ）−Ａ１３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ａ１３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ａ１３２、−ＮＨ−Ｃ（Ｏ）−ＮＡ１３３Ａ１３４、−ＮＡ１３５−Ｃ（Ｏ）−Ｏ−Ａ１３６、−ＮＡ１３７−Ｃ（Ｏ）−ＮＨ−Ａ１３８、−ＮＡ１３９−Ｃ（Ｏ）−ＮＡ１４０Ａ１４１、−ＮＨＳ（Ｏ₂）−Ａ１４２、−ＮＡ１４３Ｓ（Ｏ₂）−Ａ１４４、−Ｓ−Ａ１４５、−Ｓ（Ｏ）−Ａ１４６、−Ｓ（Ｏ₂）−Ａ１４７、−Ｓ（Ｏ₂）ＮＨ−Ａ１４８、−Ｓ（Ｏ₂）ＮＡ１４９Ａ１５０、−Ｓ（Ｏ₂）Ｏ−Ａ１５１、−Ｐ（Ｏ）（ＯＡ１５２）（ＯＡ１５３）、−Ｓｉ（Ａ１５４）（Ａ１５５）（Ａ１５６）"；
その際、Ａ１０５、Ａ１０６、Ａ１０７、Ａ１０８、Ａ１０９、Ａ１１０、Ａ１１１、Ａ１１２、Ａ１１３、Ａ１１４、Ａ１１５、Ａ１１６、Ａ１１７、Ａ１１８、Ａ１１９、Ａ１２０、Ａ１２１、Ａ１２２、Ａ１２３、Ａ１２４、Ａ１２５、Ａ１２６、Ａ１２７、Ａ１２８、Ａ１２９、Ａ１３０、Ａ１３１、Ａ１３２、Ａ１３３、Ａ１３４、Ａ１３５、Ａ１３６、Ａ１３７、Ａ１３８、Ａ１３９、Ａ１４０、Ａ１４１、Ａ１４２、Ａ１４３、Ａ１４４、Ａ１４５、Ａ１４６、Ａ１４７、Ａ１４８、Ａ１４９、Ａ１５０、Ａ１５１、Ａ１５２、Ａ１５３、Ａ１５４、Ａ１５５、Ａ１５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＡ１１１、Ａ１１２及び／又はＡ１２０、Ａ１２１及び／又はＡ１３３、Ａ１３４及び／又はＡ１４０、Ａ１４１及び／又はＡ１４９、Ａ１５０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
又は
（Ｅ）
基Ｚ１、Ｚ２の一方もしくは両方の基Ｚ１、Ｚ２は、互いに無関係に、以下のものからなる群から選択される：
（ａ）−ＮＺ２４Ｚ２５；
但し、基Ｚ２４、Ｚ２５の一方もしくは両方の基Ｚ２４、Ｚ２５は、互いに無関係に、以下のものからなる群から選択される：
（１）"−Ｃ（Ｏ）−Ｃ（Ｏ）−Ｔ１、−Ｓ（Ｏ₂）−ＮＴ２Ｔ３"；
その際、Ｔ１、Ｔ２、Ｔ３は、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ４、−ＮＴ５Ｔ６、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ７、−Ｃ（Ｏ）Ｏ−Ｔ８、−Ｃ（Ｏ）ＮＨ−Ｔ９、−Ｃ（Ｏ）ＮＴ１０Ｔ１１、−Ｏ−Ｔ１２、−Ｏ（−Ｔ１３−Ｏ）_p−Ｈ（ｐ＝１、２、３、４、５）、−Ｏ（−Ｔ１４−Ｏ）_p−Ｔ１５（ｐ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１６、−ＯＣ（Ｏ）−Ｏ−Ｔ１７、−ＯＣ（Ｏ）−ＮＨＴ１８、−Ｏ−Ｃ（Ｏ）−ＮＴ１９Ｔ２０、−ＯＰ（Ｏ）（ＯＴ２１）（ＯＴ２２）、−ＯＳｉ（Ｔ２３）（Ｔ２４）（Ｔ２５）、−ＯＳ（Ｏ₂）−Ｔ２６、−ＮＨＣ（Ｏ）−Ｔ２７、−ＮＴ２８Ｃ（Ｏ）−Ｔ２９、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ３０、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ３１、−ＮＨ−Ｃ（Ｏ）−ＮＴ３２Ｔ３３、−ＮＴ３４−Ｃ（Ｏ）−Ｏ−Ｔ３５、−ＮＴ３６−Ｃ（Ｏ）−ＮＨ−Ｔ３７、−ＮＴ３８−Ｃ（Ｏ）−ＮＴ３９Ｔ４０、−ＮＨＳ（Ｏ₂）−Ｔ４１、−ＮＴ４２Ｓ（Ｏ₂）−Ｔ４３、−Ｓ−Ｔ４４、−Ｓ（Ｏ）−Ｔ４５、−Ｓ（Ｏ₂）−Ｔ４６、−Ｓ（Ｏ₂）ＮＨ−Ｔ４７、−Ｓ（Ｏ₂）ＮＴ４８Ｔ４９、−Ｓ（Ｏ₂）Ｏ−Ｔ５０、−Ｐ（Ｏ）（ＯＴ５１）（ＯＴ５２）、−Ｓｉ（Ｔ５３）（Ｔ５４）（Ｔ５５）"；
その際、Ｔ４、Ｔ５、Ｔ６、Ｔ７、Ｔ８、Ｔ９、Ｔ１０、Ｔ１１、Ｔ１２、Ｔ１３、Ｔ１４、Ｔ１５、Ｔ１６、Ｔ１７、Ｔ１８、Ｔ１９、Ｔ２０、Ｔ２１、Ｔ２２、Ｔ２３、Ｔ２４、Ｔ２５、Ｔ２６、Ｔ２７、Ｔ２８、Ｔ２９、Ｔ３０、Ｔ３１、Ｔ３２、Ｔ３３、Ｔ３４、Ｔ３５、Ｔ３６、Ｔ３７、Ｔ３８、Ｔ３９、Ｔ４０、Ｔ４１、Ｔ４２、Ｔ４３、Ｔ４４、Ｔ４５、Ｔ４６、Ｔ４７、Ｔ４８、Ｔ４９、Ｔ５０、Ｔ５１、Ｔ５２、Ｔ５３、Ｔ５４、Ｔ５５は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１０、Ｔ１１及び／又はＴ１９、Ｔ２０及び／又はＴ３２、Ｔ３３及び／又はＴ３９、Ｔ４０及び／又はＴ４８、Ｔ４９は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（Ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ５６、−ＮＴ５７Ｔ５８、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ５９、−Ｃ（Ｏ）Ｏ−Ｔ６０、−Ｃ（Ｏ）ＮＨ−Ｔ６１、−Ｃ（Ｏ）ＮＴ６２Ｔ６３、−Ｏ−Ｔ６４、−Ｏ（−Ｔ６５−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｔ６６−Ｏ）_r−Ｔ６７（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ６８、−ＯＣ（Ｏ）−Ｏ−Ｔ６９、−ＯＣ（Ｏ）−ＮＨＴ７０、−Ｏ−Ｃ（Ｏ）−ＮＴ７１Ｔ７２、−ＯＰ（Ｏ）（ＯＴ７３）（ＯＴ７４）、−ＯＳｉ（Ｔ７５）（Ｔ７６）（Ｔ７７）、−ＯＳ（Ｏ₂）−Ｔ７８、−ＮＨＣ（Ｏ）−Ｔ７９、−ＮＴ８０Ｃ（Ｏ）−Ｔ８１、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ８２、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ８３、−ＮＨ−Ｃ（Ｏ）−ＮＴ８４Ｔ８５、−ＮＴ８６−Ｃ（Ｏ）−Ｏ−Ｔ８７、−ＮＴ８８−Ｃ（Ｏ）−ＮＨ−Ｔ８９、−ＮＴ９０−Ｃ（Ｏ）−ＮＴ９１Ｔ９２、−ＮＨＳ（Ｏ₂）−Ｔ９３、−ＮＴ９４Ｓ（Ｏ₂）−Ｔ９５、−Ｓ−Ｔ９６、−Ｓ（Ｏ）−Ｔ９７、−Ｓ（Ｏ₂）−Ｔ９８、−Ｓ（Ｏ₂）ＮＨ−Ｔ９９、−Ｓ（Ｏ₂）ＮＴ１００Ｔ１０１、−Ｓ（Ｏ₂）Ｏ−Ｔ１０２、−Ｐ（Ｏ）（ＯＴ１０３）（ＯＴ１０４）、−Ｓｉ（Ｔ１０５）（Ｔ１０６）（Ｔ１０７）"；
その際、Ｔ５６、Ｔ５７、Ｔ５８、Ｔ５９、Ｔ６０、Ｔ６１、Ｔ６２、Ｔ６３、Ｔ６４、Ｔ６５、Ｔ６６、Ｔ６７、Ｔ６８、Ｔ６９、Ｔ７０、Ｔ７１、Ｔ７２、Ｔ７３、Ｔ７４、Ｔ７５、Ｔ７６、Ｔ７７、Ｔ７８、Ｔ７９、Ｔ８０、Ｔ８１、Ｔ８２、Ｔ８３、Ｔ８４、Ｔ８５、Ｔ８６、Ｔ８７、Ｔ８８、Ｔ８９、Ｔ９０、Ｔ９１、Ｔ９２、Ｔ９３、Ｔ９４、Ｔ９５、Ｔ９６、Ｔ９７、Ｔ９８、Ｔ９９、Ｔ１００、Ｔ１０１、Ｔ１０２、Ｔ１０３、Ｔ１０４、Ｔ１０５、Ｔ１０６、Ｔ１０７は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ６２、Ｔ６３及び／又はＴ７１、Ｔ７２及び／又はＴ８４、Ｔ８５及び／又はＴ９１、Ｔ９２及び／又はＴ１００、Ｔ１０１は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１０８、−ＮＴ１０９Ｔ１１０、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１１１、−Ｃ（Ｏ）Ｏ−Ｔ１１２、−Ｃ（Ｏ）ＮＨ−Ｔ１１３、−Ｃ（Ｏ）ＮＴ１１４Ｔ１１５、−Ｏ−Ｔ１１６、−Ｏ（−Ｔ１１７−Ｏ）_s−Ｈ（ｓ＝１、２、３、４、５）、−Ｏ（−Ｔ１１８−Ｏ）_s−Ｔ１１９（ｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１２０、−ＯＣ（Ｏ）−Ｏ−Ｔ１２１、−ＯＣ（Ｏ）−ＮＨＴ１２２、−Ｏ−Ｃ（Ｏ）−ＮＴ１２３Ｔ１２４、−ＯＰ（Ｏ）（ＯＴ１２５）（ＯＴ１２６）、−ＯＳｉ（Ｔ１２７）（Ｔ１２８）（Ｔ１２９）、−ＯＳ（Ｏ₂）−Ｔ１３０、−ＮＨＣ（Ｏ）−Ｔ１３１、−ＮＴ１３２Ｃ（Ｏ）−Ｔ１３３、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１３４、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１３５、−ＮＨ−Ｃ（Ｏ）−ＮＴ１３６Ｔ１３７、−ＮＴ１３８−Ｃ（Ｏ）−Ｏ−Ｔ１３９、−ＮＴ１４０−Ｃ（Ｏ）−ＮＨ−Ｔ１４１、−ＮＴ１４２−Ｃ（Ｏ）−ＮＴ１４３Ｔ１４４、−ＮＨＳ（Ｏ₂）−Ｔ１４５、−ＮＴ１４６Ｓ（Ｏ₂）−Ｔ１４７、−Ｓ−Ｔ１４８、−Ｓ（Ｏ）−Ｔ１４９、−Ｓ（Ｏ₂）−Ｔ１５０、−Ｓ（Ｏ₂）ＮＨ−Ｔ１５１、−Ｓ（Ｏ₂）ＮＴ１５２Ｔ１５３、−Ｓ（Ｏ₂）Ｏ−Ｔ１５４、−Ｐ（Ｏ）（ＯＴ１５５）（ＯＴ１５６）、−Ｓｉ（Ｔ１５７）（Ｔ１５８）（Ｔ１５９）"；
その際、Ｔ１０８、Ｔ１０９、Ｔ１１０、Ｔ１１１、Ｔ１１２、Ｔ１１３、Ｔ１１４、Ｔ１１５、Ｔ１１６、Ｔ１１７、Ｔ１１８、Ｔ１１９、Ｔ１２０、Ｔ１２１、Ｔ１２２、Ｔ１２３、Ｔ１２４、Ｔ１２５、Ｔ１２６、Ｔ１２７、Ｔ１２８、Ｔ１２９、Ｔ１３０、Ｔ１３１、Ｔ１３２、Ｔ１３３、Ｔ１３４、Ｔ１３５、Ｔ１３６、Ｔ１３７、Ｔ１３８、Ｔ１３９、Ｔ１４０、Ｔ１４１、Ｔ１４２、Ｔ１４３、Ｔ１４４、Ｔ１４５、Ｔ１４６、Ｔ１４７、Ｔ１４８、Ｔ１４９、Ｔ１５０、Ｔ１５１、Ｔ１５２、Ｔ１５３、Ｔ１５４、Ｔ１５５、Ｔ１５６、Ｔ１５７、Ｔ１５８、Ｔ１５９は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１１４、Ｔ１１５及び／又はＴ１２３、Ｔ１２４及び／又はＴ１３６、Ｔ１３７及び／又はＴ１４３、Ｔ１４４及び／又はＴ１５２、Ｔ１５３は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１６０、−ＮＴ１６１Ｔ１６２、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１６３、−Ｃ（Ｏ）Ｏ−Ｔ１６４、−Ｃ（Ｏ）ＮＨ−Ｔ１６５、−Ｃ（Ｏ）ＮＴ１６６Ｔ１６７、−Ｏ−Ｔ１６８、−Ｏ（−Ｔ１６９−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｔ１７０−Ｏ）_t−Ｔ１７１（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１７２、−ＯＣ（Ｏ）−Ｏ−Ｔ１７３、−ＯＣ（Ｏ）−ＮＨＴ１７４、−Ｏ−Ｃ（Ｏ）−ＮＴ１７５Ｔ１７６、−ＯＰ（Ｏ）（ＯＴ１７７）（ＯＴ１７８）、−ＯＳｉ（Ｔ１７９）（Ｔ１８０）（Ｔ１８１）、−ＯＳ（Ｏ₂）−Ｔ１８２、−ＮＨＣ（Ｏ）−Ｔ１８３、−ＮＴ１８４Ｃ（Ｏ）−Ｔ１８５、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１８６、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１８７、−ＮＨ−Ｃ（Ｏ）−ＮＴ１８８Ｔ１８９、−ＮＴ１９０−Ｃ（Ｏ）−Ｏ−Ｔ１９１、−ＮＴ１９２−Ｃ（Ｏ）−ＮＨ−Ｔ１９３、−ＮＴ１９４−Ｃ（Ｏ）−ＮＴ１９５Ｔ１９６、−ＮＨＳ（Ｏ₂）−Ｔ１９７、−ＮＴ１９８Ｓ（Ｏ₂）−Ｔ１９９、−Ｓ−Ｔ２００、−Ｓ（Ｏ）−Ｔ２０１、−Ｓ（Ｏ₂）−Ｔ２０２、−Ｓ（Ｏ₂）ＮＨ−Ｔ２０３、−Ｓ（Ｏ₂）ＮＴ２０４Ｔ２０５、−Ｓ（Ｏ₂）Ｏ−Ｔ２０６、−Ｐ（Ｏ）（ＯＴ２０７）（ＯＴ２０８）、−Ｓｉ（Ｔ２０９）（Ｔ２１０）（Ｔ２１１）"；
その際、Ｔ１６０、Ｔ１６１、Ｔ１６２、Ｔ１６３、Ｔ１６４、Ｔ１６５、Ｔ１６６、Ｔ１６７、Ｔ１６８、Ｔ１６９、Ｔ１７０、Ｔ１７１、Ｔ１７２、Ｔ１７３、Ｔ１７４、Ｔ１７５、Ｔ１７６、Ｔ１７７、Ｔ１７８、Ｔ１７９、Ｔ１８０、Ｔ１８１、Ｔ１８２、Ｔ１８３、Ｔ１８４、Ｔ１８５、Ｔ１８６、Ｔ１８７、Ｔ１８８、Ｔ１８９、Ｔ１９０、Ｔ１９１、Ｔ１９２、Ｔ１９３、Ｔ１９４、Ｔ１９５、Ｔ１９６、Ｔ１９７、Ｔ１９８、Ｔ１９９、Ｔ２００、Ｔ２０１、Ｔ２０２、Ｔ２０３、Ｔ２０４、Ｔ２０５、Ｔ２０６、Ｔ２０７、Ｔ２０８、Ｔ２０９、Ｔ２１０、Ｔ２１１は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１６６、Ｔ１６７及び／又はＴ１７５、Ｔ１７６及び／又はＴ１８８、Ｔ１８９及び／又はＴ１９５、Ｔ１９６及び／又はＴ２０４、Ｔ２０５は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、選択的に、Ｔ２、Ｔ３は、一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ２４、Ｚ２５の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ２４、Ｚ２５のどちらも、以下のものからなる群から選択されない：
（２）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（２）の前記の置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ２１２、−ＮＴ２１３Ｔ２１４、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ２１５、−Ｃ（Ｏ）Ｏ−Ｔ２１６、−Ｃ（Ｏ）ＮＨ−Ｔ２１７、−Ｃ（Ｏ）ＮＴ２１８Ｔ２１９、−Ｏ−Ｔ２２０、−Ｏ（−Ｔ２２１−Ｏ）_u−Ｈ（ｕ＝１、２、３、４、５）、−Ｏ（−Ｔ２２２−Ｏ）_u−Ｔ２２３（ｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ２２４、−ＯＣ（Ｏ）−Ｏ−Ｔ２２５、−ＯＣ（Ｏ）−ＮＨＴ２２６、−Ｏ−Ｃ（Ｏ）−ＮＴ２２７Ｔ２２８、−ＯＰ（Ｏ）（ＯＴ２２９）（ＯＴ２３０）、−ＯＳｉ（Ｔ２３１）（Ｔ２３２）（Ｔ２３３）、−ＯＳ（Ｏ₂）−Ｔ２３４、−ＮＨＣ（Ｏ）−Ｔ２３５、−ＮＴ２３６Ｃ（Ｏ）−Ｔ２３７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ２３８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ２３９、−ＮＨ−Ｃ（Ｏ）−ＮＴ２４０Ｔ２４１、−ＮＴ２４２−Ｃ（Ｏ）−Ｏ−Ｔ２４３、−ＮＴ２４４−Ｃ（Ｏ）−ＮＨ−Ｔ２４５、−ＮＴ２４６−Ｃ（Ｏ）−ＮＴ２４７Ｔ２４８、−ＮＨＳ（Ｏ₂）−Ｔ２４９、−ＮＴ２５０Ｓ（Ｏ₂）−Ｔ２５１、−Ｓ−Ｔ２５２、−Ｓ（Ｏ）−Ｔ２５３、−Ｓ（Ｏ₂）−Ｔ２５４、−Ｓ（Ｏ₂）ＮＨ−Ｔ２５５、−Ｓ（Ｏ₂）ＮＴ２５６Ｔ２５７、−Ｓ（Ｏ₂）Ｏ−Ｔ２５８、−Ｐ（Ｏ）（ＯＴ２５９）（ＯＴ２６０）、−Ｓｉ（Ｔ２６１）（Ｔ２６２）（Ｔ２６３）"；
その際、Ｔ２１２、Ｔ２１３、Ｔ２１４、Ｔ２１５、Ｔ２１６、Ｔ２１７、Ｔ２１８、Ｔ２１９、Ｔ２２０、Ｔ２２１、Ｔ２２２、Ｔ２２３、Ｔ２２４、Ｔ２２５、Ｔ２２６、Ｔ２２７、Ｔ２２８、Ｔ２２９、Ｔ２３０、Ｔ２３１、Ｔ２３２、Ｔ２３３、Ｔ２３４、Ｔ２３５、Ｔ２３６、Ｔ２３７、Ｔ２３８、Ｔ２３９、Ｔ２４０、Ｔ２４１、Ｔ２４２、Ｔ２４３、Ｔ２４４、Ｔ２４５、Ｔ２４６、Ｔ２４７、Ｔ２４８、Ｔ２４９、Ｔ２５０、Ｔ２５１、Ｔ２５２、Ｔ２５３、Ｔ２５４、Ｔ２５５、Ｔ２５６、Ｔ２５７、Ｔ２５８、Ｔ２５９、Ｔ２６０、Ｔ２６１、Ｔ２６２、Ｔ２６３は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ２１８、Ｔ２１９及び／又はＴ２２７、Ｔ２２８及び／又はＴ２４０、Ｔ２４１及び／又はＴ２４７、Ｔ２４８及び／又はＴ２５６、Ｔ２５７は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい；
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ２６４、−ＮＴ２６５Ｔ２６６、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ２６７、−Ｃ（Ｏ）Ｏ−Ｔ２６８、−Ｃ（Ｏ）ＮＨ−Ｔ２６９、−Ｃ（Ｏ）ＮＴ２７０Ｔ２７１、−Ｏ−Ｔ２７２、−Ｏ（−Ｔ２７３−Ｏ）_v−Ｈ（ｖ＝１、２、３、４、５）、−Ｏ（−Ｔ２７４−Ｏ）_v−Ｔ２７５（ｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ２７６、−ＯＣ（Ｏ）−Ｏ−Ｔ２７７、−ＯＣ（Ｏ）−ＮＨＴ２７８、−Ｏ−Ｃ（Ｏ）−ＮＴ２７９Ｔ２８０、−ＯＰ（Ｏ）（ＯＴ２８１）（ＯＴ２８２）、−ＯＳｉ（Ｔ２８３）（Ｔ２８４）（Ｔ２８５）、−ＯＳ（Ｏ₂）−Ｔ２８６、−ＮＨＣ（Ｏ）−Ｔ２８７、−ＮＴ２８８Ｃ（Ｏ）−Ｔ２８９、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ２９０、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ２９１、−ＮＨ−Ｃ（Ｏ）−ＮＴ２９２Ｔ２９３、−ＮＴ２９４−Ｃ（Ｏ）−Ｏ−Ｔ２９５、−ＮＴ２９６−Ｃ（Ｏ）−ＮＨ−Ｔ２９７、−ＮＴ２９８−Ｃ（Ｏ）−ＮＴ２９９Ｔ３００、−ＮＨＳ（Ｏ₂）−Ｔ３０１、−ＮＴ３０２Ｓ（Ｏ₂）−Ｔ３０３、−Ｓ−Ｔ３０４、−Ｓ（Ｏ）−Ｔ３０５、−Ｓ（Ｏ₂）−Ｔ３０６、−Ｓ（Ｏ₂）ＮＨ−Ｔ３０７、−Ｓ（Ｏ₂）ＮＴ３０８Ｔ３０９、−Ｓ（Ｏ₂）Ｏ−Ｔ３１０、−Ｐ（Ｏ）（ＯＴ３１１）（ＯＴ３１２）、−Ｓｉ（Ｔ３１３）（Ｔ３１４）（Ｔ３１５）"；
その際、Ｔ２６４、Ｔ２６５、Ｔ２６６、Ｔ２６７、Ｔ２６８、Ｔ２６９、Ｔ２７０、Ｔ２７１、Ｔ２７２、Ｔ２７３、Ｔ２７４、Ｔ２７５、Ｔ２７６、Ｔ２７７、Ｔ２７８、Ｔ２７９、Ｔ２８０、Ｔ２８１、Ｔ２８２、Ｔ２８３、Ｔ２８４、Ｔ２８５、Ｔ２８６、Ｔ２８７、Ｔ２８８、Ｔ２８９、Ｔ２９０、Ｔ２９１、Ｔ２９２、Ｔ２９３、Ｔ２９４、Ｔ２９５、Ｔ２９６、Ｔ２９７、Ｔ２９８、Ｔ２９９、Ｔ３００、Ｔ３０１、Ｔ３０２、Ｔ３０３、Ｔ３０４、Ｔ３０５、Ｔ３０６、Ｔ３０７、Ｔ３０８、Ｔ３０９、Ｔ３１０、Ｔ３１１、Ｔ３１２、Ｔ３１３、Ｔ３１４、Ｔ３１５は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ２７０、Ｔ２７１及び／又はＴ２７９、Ｔ２８０及び／又はＴ２９２、Ｔ２９３及び／又はＴ２９９、Ｔ３００及び／又はＴ３０８、Ｔ３０９は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ３１６、−ＮＴ３１７Ｔ３１８、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ３１９、−Ｃ（Ｏ）Ｏ−Ｔ３２０、−Ｃ（Ｏ）ＮＨ−Ｔ３２１、−Ｃ（Ｏ）ＮＴ３２２Ｔ３２３、−Ｏ−Ｔ３２４、−Ｏ（−Ｔ３２５−Ｏ）_w−Ｈ（ｗ＝１、２、３、４、５）、−Ｏ（−Ｔ３２６−Ｏ）_w−Ｔ３２７（ｗ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ３２８、−ＯＣ（Ｏ）−Ｏ−Ｔ３２９、−ＯＣ（Ｏ）−ＮＨＴ３３０、−Ｏ−Ｃ（Ｏ）−ＮＴ３３１Ｔ３３２、−ＯＰ（Ｏ）（ＯＴ３３３）（ＯＴ３３４）、−ＯＳｉ（Ｔ３３５）（Ｔ３３６）（Ｔ３３７）、−ＯＳ（Ｏ₂）−Ｔ３３８、−ＮＨＣ（Ｏ）−Ｔ３３９、−ＮＴ３４０Ｃ（Ｏ）−Ｔ３４１、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ３４２、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ３４３、−ＮＨ−Ｃ（Ｏ）−ＮＴ３４４Ｔ３４５、−ＮＴ３４６−Ｃ（Ｏ）−Ｏ−Ｔ３４７、−ＮＴ３４８−Ｃ（Ｏ）−ＮＨ−Ｔ３４９、−ＮＴ３５０−Ｃ（Ｏ）−ＮＴ３５１Ｔ３５２、−ＮＨＳ（Ｏ₂）−Ｔ３５３、−ＮＴ３５４Ｓ（Ｏ₂）−Ｔ３５５、−Ｓ−Ｔ３５６、−Ｓ（Ｏ）−Ｔ３５７、−Ｓ（Ｏ₂）−Ｔ３５８、−Ｓ（Ｏ₂）ＮＨ−Ｔ３５９、−Ｓ（Ｏ₂）ＮＴ３６０Ｔ３６１、−Ｓ（Ｏ₂）Ｏ−Ｔ３６２Ｔ、−Ｐ（Ｏ）（ＯＴ３６３）（ＯＴ３６４）、−Ｓｉ（Ｔ３６５）（Ｔ３６６）（Ｔ３６７）"；
その際、Ｔ３１６、Ｔ３１７、Ｔ３１８、Ｔ３１９、Ｔ３２０、Ｔ３２１、Ｔ３２２、Ｔ３２３、Ｔ３２４、Ｔ３２５、Ｔ３２６、Ｔ３２７、Ｔ３２８、Ｔ３２９、Ｔ３３０、Ｔ３３１、Ｔ３３２、Ｔ３３３、Ｔ３３４、Ｔ３３５、Ｔ３３６、Ｔ３３７、Ｔ３３８、Ｔ３３９、Ｔ３４０、Ｔ３４１、Ｔ３４２、Ｔ３４３、Ｔ３４４、Ｔ３４５、Ｔ３４６、Ｔ３４７、Ｔ３４８、Ｔ３４９、Ｔ３５０、Ｔ３５１、Ｔ３５２、Ｔ３５３、Ｔ３５４、Ｔ３５５、Ｔ３５６、Ｔ３５７、Ｔ３５８、Ｔ３５９、Ｔ３６０、Ｔ３６１、Ｔ３６２、Ｔ３６３、Ｔ３６４、Ｔ３６５、Ｔ３６６、Ｔ３６７は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ３２２、Ｔ３２３及び／又はＴ３３１、Ｔ３３２及び／又はＴ３４４、Ｔ３４５及び／又はＴ３５１、Ｔ３５２及び／又はＴ３６０、Ｔ３６１は、一緒になって、"ヘテロシクリル"を形成することもできる；
（ｂ）−ＮＺ２６Ｚ２７、
その際、基Ｚ２６、Ｚ２７の一方もしくは両方の基Ｚ２６、Ｚ２７は、互いに無関係に、以下のものからなる群から選択される：
（１）"−Ｃ（Ｙ４）ＮＺ２８Ｚ２９、−Ｃ（＝ＮＺ３０）−Ｚ３１"；
その際、Ｙ４は、互いに無関係に、"Ｏ、Ｓ、＝ＮＨ、＝ＮＺ３２"からなる群から選択される；
但し、基Ｚ２８、Ｚ２９の少なくとも１つ及び基Ｚ３０、Ｚ３１の少なくとも１つは、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−ヘテロアリール"；
但し、更に、置換基群（Ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されている：
（ｉ）"Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキルアルキル、ヘテロシクリルアルキル、アリールアルキル、ヘテロアリールアルキル、−ＮＴ３６８Ｔ３６９、−ＮＨＣ（Ｏ）−シクロアルキルアルキル、−ＮＨＣ（Ｏ）−ヘテロシクリルアルキル、−ＮＴ３７０Ｃ（Ｏ）−Ｔ３７１、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ３７２、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ３７３、−ＮＨ−Ｃ（Ｏ）−ＮＴ３７４Ｔ３７５、−ＮＴ３７６−Ｃ（Ｏ）−Ｏ−Ｔ３７７、−ＮＴ３７８−Ｃ（Ｏ）−ＮＨ−Ｔ３７９、−ＮＴ３８０−Ｃ（Ｏ）−ＮＴ３８１Ｔ３８２、−ＮＨＳ（Ｏ₂）−シクロアルキルアルキル、−ＮＨＳ（Ｏ₂）−ヘテロシクリルアルキル、−ＮＴ３８３Ｓ（Ｏ₂）−Ｔ３８４、−Ｏ−Ｔ３８５、−Ｏ（−Ｔ３８６−Ｏ）_x−Ｔ３８７（ｘ＝１、２、３、４、５）、−Ｏ（−Ｔ３８８−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−シクロアルキルアルキル、−ＯＣ（Ｏ）−ヘテロシクリルアルキル、−ＯＣ（Ｏ）−Ｏ−Ｔ３８９、−ＯＣ（Ｏ）−ＮＨＴ３９０、−Ｏ−Ｃ（Ｏ）−ＮＴ３９１Ｔ３９２、−ＯＳ（Ｏ₂）−シクロアルキルアルキル、−ＯＳ（Ｏ₂）−ヘテロシクリルアルキル、−ＯＰ（Ｏ）（ＯＴ３９３）（ＯＴ３９４）、−ＯＳｉ（Ｔ３９５）（Ｔ３９６）（Ｔ３９７）、−ＣＨＯ、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｓ−シクロアルキルアルキル、−Ｓ−ヘテロシクリルアルキル、−Ｓ−アリールアルキル、−Ｓ−ヘテロアリールアルキル、−Ｓ（Ｏ）−シクロアルキル、−Ｓ（Ｏ）−ヘテロシクリル、−Ｓ（Ｏ）−ヘテロアリール、−Ｓ（Ｏ）−シクロアルキルアルキル、−Ｓ（Ｏ）−ヘテロシクリルアルキル、−Ｓ（Ｏ）−アリールアルキル、−Ｓ（Ｏ）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）ＮＨ−シクロアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロシクリル、−Ｓ（Ｏ₂）ＮＨ−シクロアルキルアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）ＮＨ−ヘテロアリールアルキル、−Ｓ（Ｏ₂）ＮＴ３９８Ｔ３９９、−Ｓ（Ｏ₂）Ｏ−シクロアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロシクリル、−Ｓ（Ｏ₂）Ｏ−ヘテロアリール、−Ｓ（Ｏ₂）Ｏ−シクロアルキルアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）Ｏ−ヘテロアリールアルキル、−Ｐ（Ｏ）（ＯＨ）₂、−Ｐ（Ｏ）（ＯＴ４００）（ＯＴ４０１）、−Ｓｉ（Ｔ４０２）（Ｔ４０３）（Ｔ４０４）"；
但し、更に、"−Ｎ（アルキル）₂"、"−Ｃ（Ｏ）Ｎ（アルキル）₂"、"−Ｃ（Ｏ）Ｎ（シクロアルキル）₂"、"−Ｃ（Ｏ）Ｎ（アリール）₂"、"−Ｃ（Ｏ）Ｎ（ヘテロアリール）₂"は、以下の置換基群（ｉｉ）から選択される、少なくとも１つの置換基によって更に置換されている；
その際、Ｔ３６８、Ｔ３６９、Ｔ３７０、Ｔ３７１、Ｔ３７２、Ｔ３７３、Ｔ３７４、Ｔ３７５、Ｔ３７６、Ｔ３７７、Ｔ３７８、Ｔ３７９、Ｔ３８０、Ｔ３８１、Ｔ３８２、Ｔ３８３、Ｔ３８４、Ｔ３８５、Ｔ３８６、Ｔ３８７、Ｔ３８８、Ｔ３８９、Ｔ３９０、Ｔ３９１、Ｔ３９２、Ｔ３９３、Ｔ３９４、Ｔ３９５、Ｔ３９６、Ｔ３９７、Ｔ３９８、Ｔ３９９、Ｔ４００、Ｔ４０１、Ｔ４０２、Ｔ４０３、Ｔ４０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ３７４、Ｔ３７５及び／又はＴ３８１、Ｔ３８２及び／又はＴ３９１、Ｔ３９２及び／又はＴ３９８、Ｔ３９９は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ４０５、−ＮＴ４０６Ｔ４０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ４０８、−Ｃ（Ｏ）Ｏ−Ｔ４０９、−Ｃ（Ｏ）ＮＨ−Ｔ４１０、−Ｃ（Ｏ）ＮＴ４１１Ｔ４１２、−Ｏ−Ｔ４１３、−Ｏ（−Ｔ４１４−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｔ４１５−Ｏ）_y−Ｔ４１６（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ４１７、−ＯＣ（Ｏ）−Ｏ−Ｔ４１８、−ＯＣ（Ｏ）−ＮＨＴ４１９、−Ｏ−Ｃ（Ｏ）−ＮＴ４２０Ｔ４２１、−ＯＰ（Ｏ）（ＯＴ４２２）（ＯＴ４２３）、−ＯＳｉ（Ｔ４２４）（Ｔ４２５）（Ｔ４２６）、−ＯＳ（Ｏ₂）−Ｔ４２７、−ＮＨＣ（Ｏ）−Ｔ４２８、−ＮＴ４２９Ｃ（Ｏ）−Ｔ４３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ４３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ４３２、−ＮＨ−Ｃ（Ｏ）−ＮＴ４３３Ｔ４３４、−ＮＴ４３５−Ｃ（Ｏ）−Ｏ−Ｔ４３６、−ＮＴ４３７−Ｃ（Ｏ）−ＮＨ−Ｔ４３８、−ＮＴ４３９−Ｃ（Ｏ）−ＮＴ４４０Ｔ４４１、−ＮＨＳ（Ｏ₂）−Ｔ４４２、−ＮＴ４４３Ｓ（Ｏ₂）−Ｔ４４４、−Ｓ−Ｔ４４５、−Ｓ（Ｏ）−Ｔ４４６、−Ｓ（Ｏ₂）−Ｔ４４７、−Ｓ（Ｏ₂）ＮＨ−Ｔ４４８、−Ｓ（Ｏ₂）ＮＴ４４９Ｔ４５０、−Ｓ（Ｏ₂）Ｏ−Ｔ４５１、−Ｐ（Ｏ）（ＯＴ４５２）（ＯＴ４５３）、−Ｓｉ（Ｔ４５４）（Ｔ４５５）（Ｔ４５６）"；
その際、Ｔ４０５、Ｔ４０６、Ｔ４０７、Ｔ４０８、Ｔ４０９、Ｔ４１０、Ｔ４１１、Ｔ４１２、Ｔ４１３、Ｔ４１４、Ｔ４１５、Ｔ４１６、Ｔ４１７、Ｔ４１８、Ｔ４１９、Ｔ４２０、Ｔ４２１、Ｔ４２２、Ｔ４２３、Ｔ４２４、Ｔ４２５、Ｔ４２６、Ｔ４２７、Ｔ４２８、Ｔ４２９、Ｔ４３０、Ｔ４３１、Ｔ４３２、Ｔ４３３、Ｔ４３４、Ｔ４３５、Ｔ４３６、Ｔ４３７、Ｔ４３８、Ｔ４３９、Ｔ４４０、Ｔ４４１、Ｔ４４２、Ｔ４４３、Ｔ４４４、Ｔ４４５、Ｔ４４６、Ｔ４４７、Ｔ４４８、Ｔ４４９、Ｔ４５０、Ｔ４５１、Ｔ４５２、Ｔ４５３、Ｔ４５４、Ｔ４５５、Ｔ４５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ４１１、Ｔ４１２及び／又はＴ４２０、Ｔ４２１及び／又はＴ４３３、Ｔ４３４及び／又はＴ４４０、Ｔ４４１及び／又はＴ４４９、Ｔ４５０は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ４５７、−ＮＴ４５８Ｔ４５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ４６０、−Ｃ（Ｏ）Ｏ−Ｔ４６１、−Ｃ（Ｏ）ＮＨ−Ｔ４６２、−Ｃ（Ｏ）ＮＴ４６３Ｔ４６４、−Ｏ−Ｔ４６５、−Ｏ（−Ｔ４６６−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｔ４６７−Ｏ）_z−Ｔ４６８（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ４６９、−ＯＣ（Ｏ）−Ｏ−Ｔ４７０、−ＯＣ（Ｏ）−ＮＨＴ４７１、−Ｏ−Ｃ（Ｏ）−ＮＴ４７２Ｔ４７３、−ＯＰ（Ｏ）（ＯＴ４７４）（ＯＴ４７５）、−ＯＳｉ（Ｔ４７６）（Ｔ４７７）（Ｔ４７８）、−ＯＳ（Ｏ₂）−Ｔ４７９、−ＮＨＣ（Ｏ）−Ｔ４８０、−ＮＴ４８１Ｃ（Ｏ）−Ｔ４８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ４８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ４８４、−ＮＨ−Ｃ（Ｏ）−ＮＴ４８５Ｔ４８６、−ＮＴ４８７−Ｃ（Ｏ）−Ｏ−Ｔ４８８、−ＮＴ４８９−Ｃ（Ｏ）−ＮＨ−Ｔ４９０、−ＮＴ４９１−Ｃ（Ｏ）−ＮＴ４９２Ｔ４９３、−ＮＨＳ（Ｏ₂）−Ｔ４９４、−ＮＴ４９５Ｓ（Ｏ₂）−Ｔ４９６、−Ｓ−Ｔ４９７、−Ｓ（Ｏ）−Ｔ４９８、−Ｓ（Ｏ₂）−Ｔ４９９、−Ｓ（Ｏ₂）ＮＨ−Ｔ５００、−Ｓ（Ｏ₂）ＮＴ５０１Ｔ５０２、−Ｓ（Ｏ₂）Ｏ−Ｔ５０３、−Ｐ（Ｏ）（ＯＴ５０４）（ＯＴ５０５）、−Ｓｉ（Ｔ５０６）（Ｔ５０７）（Ｔ５０８）"；
その際、Ｔ４５７、Ｔ４５８、Ｔ４５９、Ｔ４６０、Ｔ４６１、Ｔ４６２、Ｔ４６３、Ｔ４６４、Ｔ４６５、Ｔ４６６、Ｔ４６７、Ｔ４６８、Ｔ４６９、Ｔ４７０、Ｔ４７１、Ｔ４７２、Ｔ４７３、Ｔ４７４、Ｔ４７５、Ｔ４７６、Ｔ４７７、Ｔ４７８、Ｔ４７９、Ｔ４８０、Ｔ４８１、Ｔ４８２、Ｔ４８３、Ｔ４８４、Ｔ４８５、Ｔ４８６、Ｔ４８７、Ｔ４８８、Ｔ４８９、Ｔ４９０、Ｔ４９１、Ｔ４９２、Ｔ４９３、Ｔ４９４、Ｔ４９５、Ｔ４９６、Ｔ４９７、Ｔ４９８、Ｔ４９９、Ｔ５００、Ｔ５０１、Ｔ５０２、Ｔ５０３、Ｔ５０４、Ｔ５０５、Ｔ５０６、Ｔ５０７、Ｔ５０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ４６３、Ｔ４６４及び／又はＴ４７２、Ｔ４７３及び／又はＴ４８５、Ｔ４８６及び／又はＴ４９２、Ｔ４９３及び／又はＴ５０１、Ｔ５０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
又は
但し、基Ｚ２８、Ｚ２９の少なくとも１つ及び基Ｚ３０、Ｚ３１の少なくとも１つは、互いに無関係に、以下のものからなる群から選択される：
（ＩＩ）"Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキルアルキル、ヘテロシクリルアルキル、アリールアルキル、ヘテロアリールアルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）−アルキル、−Ｓ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−アリール、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル"；
その際、場合により、置換基群（ＩＩ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ５０９、−ＮＴ５１０Ｔ５１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ５１２、−Ｃ（Ｏ）Ｏ−Ｔ５１３、−Ｃ（Ｏ）ＮＨ−Ｔ５１４、−Ｃ（Ｏ）ＮＴ５１５Ｔ５１６、−Ｏ−Ｔ５１７、−Ｏ（−Ｔ５１８−Ｏ）_r−Ｈ（ａ＝１、２、３、４、５）、−Ｏ（−Ｔ５１９−Ｏ）_a−Ｔ５２０（ａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ５２１、−ＯＣ（Ｏ）−Ｏ−Ｔ５２２、−ＯＣ（Ｏ）−ＮＨＴ５２３、−Ｏ−Ｃ（Ｏ）−ＮＴ５２４Ｔ５２５、−ＯＰ（Ｏ）（ＯＴ５２６）（ＯＴ５２７）、−ＯＳｉ（Ｔ５２８）（Ｔ５２９）（Ｔ５３０）、−ＯＳ（Ｏ₂）−Ｔ５３１、−ＮＨＣ（Ｏ）−Ｔ５３２、−ＮＴ５３３Ｃ（Ｏ）−Ｔ５３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ５３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ５３６、−ＮＨ−Ｃ（Ｏ）−ＮＴ５３７Ｔ５３８、−ＮＴ５３９−Ｃ（Ｏ）−Ｏ−Ｔ５４０、−ＮＴ５４１−Ｃ（Ｏ）−ＮＨ−Ｔ５４２、−ＮＴ５４３−Ｃ（Ｏ）−ＮＴ５４４Ｔ５４５、−ＮＨＳ（Ｏ₂）−Ｔ５４６、−ＮＴ５４７Ｓ（Ｏ₂）−Ｔ５４８、−Ｓ−Ｔ５４９、−Ｓ（Ｏ）−Ｔ５５０、−Ｓ（Ｏ₂）−Ｔ５５１、−Ｓ（Ｏ₂）ＮＨ−Ｔ５５２、−Ｓ（Ｏ₂）ＮＴ５５３Ｔ５５４、−Ｓ（Ｏ₂）Ｏ−Ｔ５５５、−Ｐ（Ｏ）（ＯＴ５５６）（ＯＴ５５７）、−Ｓｉ（Ｔ５５８）（Ｔ５５９）（Ｔ５６０）"；
その際、Ｔ５０９、Ｔ５１０、Ｔ５１１、Ｔ５１２、Ｔ５１３、Ｔ５１４、Ｔ５１５、Ｔ５１６、Ｔ５１７、Ｔ５１８、Ｔ５１９、Ｔ５２０、Ｔ５２１、Ｔ５２２、Ｔ５２３、Ｔ５２４、Ｔ５２５、Ｔ５２６、Ｔ５２７、Ｔ５２８、Ｔ５２９、Ｔ５３０、Ｔ５３１、Ｔ５３２、Ｔ５３３、Ｔ５３４、Ｔ５３５、Ｔ５３６、Ｔ５３７、Ｔ５３８、Ｔ５３９、Ｔ５４０、Ｔ５４１、Ｔ５４２、Ｔ５４３、Ｔ５４４、Ｔ５４５、Ｔ５４６、Ｔ５４７、Ｔ５４８、Ｔ５４９、Ｔ５５０、Ｔ５５１、Ｔ５５２、Ｔ５５３、Ｔ５５４、Ｔ５５５、Ｔ５５６、Ｔ５５７、Ｔ５５８、Ｔ５５９、Ｔ５６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ５１５、Ｔ５１６及び／又はＴ５２４、Ｔ５２５及び／又はＴ５３７、Ｔ５３８及び／又はＴ５４４、Ｔ５４５及び／又はＴ５５３、Ｔ５５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ５６１、−ＮＴ５６２Ｔ５６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ５６４、−Ｃ（Ｏ）Ｏ−Ｔ５６５、−Ｃ（Ｏ）ＮＨ−Ｔ５６６、−Ｃ（Ｏ）ＮＴ５６７Ｔ５６８、−Ｏ−Ｔ５６９、−Ｏ（−Ｔ５７０−Ｏ）_b−Ｈ（ｂ＝１、２、３、４、５）、−Ｏ（−Ｔ５７１−Ｏ）_b−Ｔ５７２（ｂ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ５７３、−ＯＣ（Ｏ）−Ｏ−Ｔ５７４、−ＯＣ（Ｏ）−ＮＨＴ５７５、−Ｏ−Ｃ（Ｏ）−ＮＴ５７６Ｔ５７７、−ＯＰ（Ｏ）（ＯＴ５７８）（ＯＴ５７９）、−ＯＳｉ（Ｔ５８０）（Ｔ５８１）（Ｔ５８２）、−ＯＳ（Ｏ₂）−Ｔ５８３、−ＮＨＣ（Ｏ）−Ｔ５８４、−ＮＴ５８５Ｃ（Ｏ）−Ｔ５８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ５８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ５８８、−ＮＨ−Ｃ（Ｏ）−ＮＴ５８９Ｔ５９０、−ＮＴ５９１−Ｃ（Ｏ）−Ｏ−Ｔ５９２、−ＮＴ５９３−Ｃ（Ｏ）−ＮＨ−Ｔ５９４、−ＮＴ５９５−Ｃ（Ｏ）−ＮＴ５９６Ｔ５９７、−ＮＨＳ（Ｏ₂）−Ｔ５９８、−ＮＴ５９９Ｓ（Ｏ₂）−Ｔ６００、−Ｓ−Ｔ６０１、−Ｓ（Ｏ）−Ｔ６０２、−Ｓ（Ｏ₂）−Ｔ６０３、−Ｓ（Ｏ₂）ＮＨ−Ｔ６０４、−Ｓ（Ｏ₂）ＮＴ６０５Ｔ６０６、−Ｓ（Ｏ₂）Ｏ−Ｔ６０７、−Ｐ（Ｏ）（ＯＴ６０８）（ＯＴ６０９）、−Ｓｉ（Ｔ６１０）（Ｔ６１１）（Ｔ６１２）"；
その際、Ｔ５６１、Ｔ５６２、Ｔ５６３、Ｔ５６４、Ｔ５６５、Ｔ５６６、Ｔ５６７、Ｔ５６８、Ｔ５６９、Ｔ５７０、Ｔ５７１、Ｔ５７２、Ｔ５７３、Ｔ５７４、Ｔ５７５、Ｔ５７６、Ｔ５７７、Ｔ５７８、Ｔ５７９、Ｔ５８０、Ｔ５８１、Ｔ５８２、Ｔ５８３、Ｔ５８４、Ｔ５８５、Ｔ５８６、Ｔ５８７、Ｔ５８８、Ｔ５８９、Ｔ５９０、Ｔ５９１、Ｔ５９２、Ｔ５９３、Ｔ５９４、Ｔ５９５、Ｔ５９６、Ｔ５９７、Ｔ５９８、Ｔ５９９、Ｔ６００、Ｔ６０１、Ｔ６０２、Ｔ６０３、Ｔ６０４、Ｔ６０５、Ｔ６０６、Ｔ６０７、Ｔ６０８、Ｔ６０９、Ｔ６１０、Ｔ６１１、Ｔ６１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ５６７、Ｔ５６８及び／又はＴ５７６、Ｔ５７７及び／又はＴ５８９、Ｔ５９０及び／又はＴ５９６、Ｔ５９７及び／又はＴ６０５、Ｔ６０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ６１３、−ＮＴ６１４Ｔ６１５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ６１６、−Ｃ（Ｏ）Ｏ−Ｔ６１７、−Ｃ（Ｏ）ＮＨ−Ｔ６１８、−Ｃ（Ｏ）ＮＴ６１９Ｔ６２０、−Ｏ−Ｔ６２１、−Ｏ（−Ｔ６２２−Ｏ）_c−Ｈ（ｃ＝１、２、３、４、５）、−Ｏ（−Ｔ６２３−Ｏ）_c−Ｔ６２４（ｃ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ６２５、−ＯＣ（Ｏ）−Ｏ−Ｔ６２６、−ＯＣ（Ｏ）−ＮＨＴ６２７、−Ｏ−Ｃ（Ｏ）−ＮＴ６２８Ｔ６２９、−ＯＰ（Ｏ）（ＯＴ６３０）（ＯＴ６３１）、−ＯＳｉ（Ｔ６３２）（Ｔ６３３）（Ｔ６３４）、−ＯＳ（Ｏ₂）−Ｔ６３５、−ＮＨＣ（Ｏ）−Ｔ６３６、−ＮＴ６３７Ｃ（Ｏ）−Ｔ６３８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ６３９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ６４０、−ＮＨ−Ｃ（Ｏ）−ＮＴ６４１Ｔ６４２、−ＮＴ６４３−Ｃ（Ｏ）−Ｏ−Ｔ６４４、−ＮＴ６４５−Ｃ（Ｏ）−ＮＨ−Ｔ６４６、−ＮＴ６４７−Ｃ（Ｏ）−ＮＴ６４８Ｔ６４９、−ＮＨＳ（Ｏ₂）−Ｔ６５０、−ＮＴ６５１Ｓ（Ｏ₂）−Ｔ６５２、−Ｓ−Ｔ６５３、−Ｓ（Ｏ）−Ｔ６５４、−Ｓ（Ｏ₂）−Ｔ６５５、−Ｓ（Ｏ₂）ＮＨ−Ｔ６５６、−Ｓ（Ｏ₂）ＮＴ６５７Ｔ６５８、−Ｓ（Ｏ₂）Ｏ−Ｔ６５９、−Ｐ（Ｏ）（ＯＴ６６０）（ＯＴ６６１）、−Ｓｉ（Ｔ６６２）（Ｔ６６３）（Ｔ６６４）"；
その際、Ｔ６１３、Ｔ６１４、Ｔ６１５、Ｔ６１６、Ｔ６１７、Ｔ６１８、Ｔ６１９、Ｔ６２０、Ｔ６２１、Ｔ６２２、Ｔ６２３、Ｔ６２４、Ｔ６２５、Ｔ６２６、Ｔ６２７、Ｔ６２８、Ｔ６２９、Ｔ６３０、Ｔ６３１、Ｔ６３２、Ｔ６３３、Ｔ６３４、Ｔ６３５、Ｔ６３６、Ｔ６３７、Ｔ６３８、Ｔ６３９、Ｔ６４０、Ｔ６４１、Ｔ６４２、Ｔ６４３、Ｔ６４４、Ｔ６４５、Ｔ６４６、Ｔ６４７、Ｔ６４８、Ｔ６４９、Ｔ６５０、Ｔ６５１、Ｔ６５２、Ｔ６５３、Ｔ６５４、Ｔ６５５、Ｔ６５６、Ｔ６５７、Ｔ６５８、Ｔ６５９、Ｔ６６０、Ｔ６６１、Ｔ６６２、Ｔ６６３、Ｔ６６４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ６１９、Ｔ６２０及び／又はＴ６２８、Ｔ６２９及び／又はＴ６４１、Ｔ６４２及び／又はＴ６４８、Ｔ６４９及び／又はＴ６５７、Ｔ６５８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ２８、Ｚ２９の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ２８、Ｚ２９のどちらも、以下のものからなる群から選択されない：
（ＩＩＩ）"水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−ヘテロアリール"；
その際、場合により、置換基群（ＩＩＩ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ６６５、−ＮＴ６６６Ｔ６６７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ６６８、−Ｃ（Ｏ）Ｏ−Ｔ６６９、−Ｃ（Ｏ）ＮＨ−Ｔ６７０、−Ｃ（Ｏ）ＮＴ６７１Ｔ６７２、−Ｏ−Ｔ６７３、−Ｏ（−Ｔ６７４−Ｏ）_d−Ｈ（ｄ＝１、２、３、４、５）、−Ｏ（−Ｔ６７５−Ｏ）_d−Ｔ６７６（ｄ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ６７７、−ＯＣ（Ｏ）−Ｏ−Ｔ６７８、−ＯＣ（Ｏ）−ＮＨＴ６７９、−Ｏ−Ｃ（Ｏ）−ＮＴ６８０Ｔ６８１、−ＯＰ（Ｏ）（ＯＴ６８２）（ＯＴ６８３）、−ＯＳｉ（Ｔ６８４）（Ｔ６８５）（Ｔ６８６）、−ＯＳ（Ｏ₂）−Ｔ６８７、−ＮＨＣ（Ｏ）−Ｔ６８８、−ＮＴ６８９Ｃ（Ｏ）−Ｔ６９０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ６９１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ６９２、−ＮＨ−Ｃ（Ｏ）−ＮＴ６９３Ｔ６９４、−ＮＴ６９５−Ｃ（Ｏ）−Ｏ−Ｔ６９６、−ＮＴ６９７−Ｃ（Ｏ）−ＮＨ−Ｔ６９８、−ＮＴ６９９−Ｃ（Ｏ）−ＮＴ７００Ｔ７０１、−ＮＨＳ（Ｏ₂）−Ｔ７０２、−ＮＴ７０３Ｓ（Ｏ₂）−Ｔ７０４、−Ｓ−Ｔ７０５、−Ｓ（Ｏ）−Ｔ７０６、−Ｓ（Ｏ₂）−Ｔ７０７、−Ｓ（Ｏ₂）ＮＨ−Ｔ７０８、−Ｓ（Ｏ₂）ＮＴ７０９Ｔ７１０、−Ｓ（Ｏ₂）Ｏ−Ｔ７１１、−Ｐ（Ｏ）（ＯＴ７１２）（ＯＴ７１３）、−Ｓｉ（Ｔ７１４）（Ｔ７１５）（Ｔ７１６）"；
その際、Ｔ６６５、Ｔ６６６、Ｔ６６７、Ｔ６６８、Ｔ６６９、Ｔ６７０、Ｔ６７１、Ｔ６７２、Ｔ６７３、Ｔ６７４、Ｔ６７５、Ｔ６７６、Ｔ６７７、Ｔ６７８、Ｔ６７９、Ｔ６８０、Ｔ６８１、Ｔ６８２、Ｔ６８３、Ｔ６８４、Ｔ６８５、Ｔ６８６、Ｔ６８７、Ｔ６８８、Ｔ６８９、Ｔ６９０、Ｔ６９１、Ｔ６９２、Ｔ６９３、Ｔ６９４、Ｔ６９５、Ｔ６９６、Ｔ６９７、Ｔ６９８、Ｔ６９９、Ｔ７００、Ｔ７０１、Ｔ７０２、Ｔ７０３、Ｔ７０４、Ｔ７０５、Ｔ７０６、Ｔ７０７、Ｔ７０８、Ｔ７０９、Ｔ７１０、Ｔ７１１、Ｔ７１２、Ｔ７１３、Ｔ７１４、Ｔ７１５、Ｔ７１６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ６７１、Ｔ６７２及び／又はＴ６８０、Ｔ６８１及び／又はＴ６９３、Ｔ６９４及び／又はＴ７００、Ｔ７０１及び／又はＴ７０９、Ｔ７１０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ７１７、−ＮＴ７１８Ｔ７１９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ７２０、−Ｃ（Ｏ）Ｏ−Ｔ７２１、−Ｃ（Ｏ）ＮＨ−Ｔ７２２、−Ｃ（Ｏ）ＮＴ７２３Ｔ７２４、−Ｏ−Ｔ７２５、−Ｏ（−Ｔ７２６−Ｏ）_e−Ｈ（ｅ＝１、２、３、４、５）、−Ｏ（−Ｔ７２７−Ｏ）_e−Ｔ７２８（ｅ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ７２９、−ＯＣ（Ｏ）−Ｏ−Ｔ７３０、−ＯＣ（Ｏ）−ＮＨＴ７３１、−Ｏ−Ｃ（Ｏ）−ＮＴ７３２Ｔ７３３、−ＯＰ（Ｏ）（ＯＴ７３４）（ＯＴ７３５）、−ＯＳｉ（Ｔ７３６）（Ｔ７３７）（Ｔ７３８）、−ＯＳ（Ｏ₂）−Ｔ７３９、−ＮＨＣ（Ｏ）−Ｔ７４０、−ＮＴ７４１Ｃ（Ｏ）−Ｔ７４２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ７４３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ７４４、−ＮＨ−Ｃ（Ｏ）−ＮＴ７４５Ｔ７４６、−ＮＴ７４７−Ｃ（Ｏ）−Ｏ−Ｔ７４８、−ＮＴ７４９−Ｃ（Ｏ）−ＮＨ−Ｔ７５０、−ＮＴ７５１−Ｃ（Ｏ）−ＮＴ７５２Ｔ７５３、−ＮＨＳ（Ｏ₂）−Ｔ７５４、−ＮＴ７５５Ｓ（Ｏ₂）−Ｔ７５６、−Ｓ−Ｔ７５７、−Ｓ（Ｏ）−Ｔ７５８、−Ｓ（Ｏ₂）−Ｔ７５９、−Ｓ（Ｏ₂）ＮＨ−Ｔ７６０、−Ｓ（Ｏ₂）ＮＴ７６１Ｔ７６２、−Ｓ（Ｏ₂）Ｏ−Ｔ７６３、−Ｐ（Ｏ）（ＯＴ７６４）（ＯＴ７６５）、−Ｓｉ（Ｔ７６６）（Ｔ７６７）（Ｔ７６８）"；
その際、Ｔ７１７、Ｔ７１８、Ｔ７１９、Ｔ７２０、Ｔ７２１、Ｔ７２２、Ｔ７２３、Ｔ７２４、Ｔ７２５、Ｔ７２６、Ｔ７２７、Ｔ７２８、Ｔ７２９、Ｔ７３０、Ｔ７３１、Ｔ７３２、Ｔ７３３、Ｔ７３４、Ｔ７３５、Ｔ７３６、Ｔ７３７、Ｔ７３８、Ｔ７３９、Ｔ７４０、Ｔ７４１、Ｔ７４２、Ｔ７４３、Ｔ７４４、Ｔ７４５、Ｔ７４６、Ｔ７４７、Ｔ７４８、Ｔ７４９、Ｔ７５０、Ｔ７５１、Ｔ７５２、Ｔ７５３、Ｔ７５４、Ｔ７５５、Ｔ７５６、Ｔ７５７、Ｔ７５８、Ｔ７５９、Ｔ７６０、Ｔ７６１、Ｔ７６２、Ｔ７６３、Ｔ７６４、Ｔ７６５、Ｔ７６６、Ｔ７６７、Ｔ７６８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ７２３、Ｔ７２４及び／又はＴ７３２、Ｔ７３３及び／又はＴ７４５、Ｔ７４６及び／又はＴ７５２、Ｔ７５３及び／又はＴ７６１、Ｔ７６２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ７６９、−ＮＴ７７０Ｔ７７１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ７７２、−Ｃ（Ｏ）Ｏ−Ｔ７７３、−Ｃ（Ｏ）ＮＨ−Ｔ７７４、−Ｃ（Ｏ）ＮＴ７７５Ｔ７７６、−Ｏ−Ｔ７７７、−Ｏ（−Ｔ７７８−Ｏ）_f−Ｈ（ｆ＝１、２、３、４、５）、−Ｏ（−Ｔ７７９−Ｏ）_f−Ｔ７８０（ｆ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ７８１、−ＯＣ（Ｏ）−Ｏ−Ｔ７８２、−ＯＣ（Ｏ）−ＮＨＴ７８３、−Ｏ−Ｃ（Ｏ）−ＮＴ７８４Ｔ７８５、−ＯＰ（Ｏ）（ＯＴ７８６）（ＯＴ７８７）、−ＯＳｉ（Ｔ７８８）（Ｔ７８９）（Ｔ７９０）、−ＯＳ（Ｏ₂）−Ｔ７９１、−ＮＨＣ（Ｏ）−Ｔ７９２、−ＮＴ７９３Ｃ（Ｏ）−Ｔ７９４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ７９５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ７９６、−ＮＨ−Ｃ（Ｏ）−ＮＴ７９７Ｔ７９８、−ＮＴ７９９−Ｃ（Ｏ）−Ｏ−Ｔ８００、−ＮＴ８０１−Ｃ（Ｏ）−ＮＨ−Ｔ８０２、−ＮＴ８０３−Ｃ（Ｏ）−ＮＴ８０４Ｔ８０５、−ＮＨＳ（Ｏ₂）−Ｔ８０６、−ＮＴ８０７Ｓ（Ｏ₂）−Ｔ８０８、−Ｓ−Ｔ８０９、−Ｓ（Ｏ）−Ｔ８１０、−Ｓ（Ｏ₂）−Ｔ８１１、−Ｓ（Ｏ₂）ＮＨ−Ｔ８１２、−Ｓ（Ｏ₂）ＮＴ８１３Ｔ８１４、−Ｓ（Ｏ₂）Ｏ−Ｔ８１５、−Ｐ（Ｏ）（ＯＴ８１６）（ＯＴ８１７）、−Ｓｉ（Ｔ８１８）（Ｔ８１９）（Ｔ８２０）"；
その際、Ｔ７６９、Ｔ７７０、Ｔ７７１、Ｔ７７２、Ｔ７７３、Ｔ７７４、Ｔ７７５、Ｔ７７６、Ｔ７７７、Ｔ７７８、Ｔ７７９、Ｔ７８０、Ｔ７８１、Ｔ７８２、Ｔ７８３、Ｔ７８４、Ｔ７８５、Ｔ７８６、Ｔ７８７、Ｔ７８８、Ｔ７８９、Ｔ７９０、Ｔ７９１、Ｔ７９２、Ｔ７９３、Ｔ７９４、Ｔ７９５、Ｔ７９６、Ｔ７９７、Ｔ７９８、Ｔ７９９、Ｔ８００、Ｔ８０１、Ｔ８０２、Ｔ８０３、Ｔ８０４、Ｔ８０５、Ｔ８０６、Ｔ８０７、Ｔ８０８、Ｔ８０９、Ｔ８１０、Ｔ８１１、Ｔ８１２、Ｔ８１３、Ｔ８１４、Ｔ８１５、Ｔ８１６、Ｔ８１７、Ｔ８１８、Ｔ８１９、Ｔ８２０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ７７５、Ｔ７７６及び／又はＴ７８４、Ｔ７８５及び／又はＴ７９７、Ｔ７９８及び／又はＴ８０４、Ｔ８０５及び／又はＴ８１３、Ｔ８１４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（２）"−Ｃ（Ｙ５）ＮＺ３３−Ｙ６−Ｚ３４"；
その際、Ｙ５、Ｔ６は、互いに無関係に、"Ｏ、Ｓ、＝ＮＨ、＝ＮＺ３５"からなる群から選択される；
その際、Ｚ３３、Ｚ３４、Ｚ３５は、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）−アルキル、−Ｓ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−アリール、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル"；
その際、場合により、置換基群（ＩＩ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される少なくとも１つの置換基によって更に置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ８２１、−ＮＴ８２２Ｔ８２３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ８２４、−Ｃ（Ｏ）Ｏ−Ｔ８２５、−Ｃ（Ｏ）ＮＨ−Ｔ８２６、−Ｃ（Ｏ）ＮＴ８２７Ｔ８２８、−Ｏ−Ｔ８２９、−Ｏ（−Ｔ８３０−Ｏ）_g−Ｈ（ｇ＝１、２、３、４、５）、−Ｏ（−Ｔ８３１−Ｏ）_g−Ｔ８３２（ｇ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ８３３、−ＯＣ（Ｏ）−Ｏ−Ｔ８３４、−ＯＣ（Ｏ）−ＮＨＴ８３５、−Ｏ−Ｃ（Ｏ）−ＮＴ８３６Ｔ８３７、−ＯＰ（Ｏ）（ＯＴ８３８）（ＯＴ８３９）、−ＯＳｉ（Ｔ８４０）（Ｔ８４１）（Ｔ８４２）、−ＯＳ（Ｏ₂）−Ｔ８４３、−ＮＨＣ（Ｏ）−Ｔ８４４、−ＮＴ８４５Ｃ（Ｏ）−Ｔ８４６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ８４７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ８４８、−ＮＨ−Ｃ（Ｏ）−ＮＴ８４９Ｔ８５０、−ＮＴ８５１−Ｃ（Ｏ）−Ｏ−Ｔ８５２、−ＮＴ８５３−Ｃ（Ｏ）−ＮＨ−Ｔ８５４、−ＮＴ８５５−Ｃ（Ｏ）−ＮＴ８５６Ｔ８５７、−ＮＨＳ（Ｏ₂）−Ｔ８５８、−ＮＴ８５９Ｓ（Ｏ₂）−Ｔ８６０、−Ｓ−Ｔ８６１、−Ｓ（Ｏ）−Ｔ８６２、−Ｓ（Ｏ₂）−Ｔ８６３、−Ｓ（Ｏ₂）ＮＨ−Ｔ８６４、−Ｓ（Ｏ₂）ＮＴ８６５Ｔ８６６、−Ｓ（Ｏ₂）Ｏ−Ｔ８６７、−Ｐ（Ｏ）（ＯＴ８６８）（ＯＴ８６９）、−Ｓｉ（Ｔ８７０）（Ｔ８７１）（Ｔ８７２）"；
その際、Ｔ８２１、Ｔ８２２、Ｔ８２３、Ｔ８２４、Ｔ８２５、Ｔ８２６、Ｔ８２７、Ｔ８２８、Ｔ８２９、Ｔ８３０、Ｔ８３１、Ｔ８３２、Ｔ８３３、Ｔ８３４、Ｔ８３５、Ｔ８３６、Ｔ８３７、Ｔ８３８、Ｔ８３９、Ｔ８４０、Ｔ８４１、Ｔ８４２、Ｔ８４３、Ｔ８４４、Ｔ８４５、Ｔ８４６、Ｔ８４７、Ｔ８４８、Ｔ８４９、Ｔ８５０、Ｔ８５１、Ｔ８５２、Ｔ８５３、Ｔ８５４、Ｔ８５５、Ｔ８５６、Ｔ８５７、Ｔ８５８、Ｔ８５９、Ｔ８６０、Ｔ８６１、Ｔ８６２、Ｔ８６３、Ｔ８６４、Ｔ８６５、Ｔ８６６、Ｔ８６７、Ｔ８６８、Ｔ８６９、Ｔ８７０、Ｔ８７１、Ｔ８７２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ８２７、Ｔ８２８及び／又はＴ８３６、Ｔ８３７及び／又はＴ８４９、Ｔ８５０及び／又はＴ８５６、Ｔ８５７及び／又はＴ８６５、Ｔ８６６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ８７３、−ＮＴ８７４Ｔ８７５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ８７６、−Ｃ（Ｏ）Ｏ−Ｔ８７７、−Ｃ（Ｏ）ＮＨ−Ｔ８７８、−Ｃ（Ｏ）ＮＴ８７９Ｔ８８０、−Ｏ−Ｔ８８１、−Ｏ（−Ｔ８８２−Ｏ）_h−Ｈ（ｈ＝１、２、３、４、５）、−Ｏ（−Ｔ８８３−Ｏ）_h−Ｔ８８４（ｈ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ８８５、−ＯＣ（Ｏ）−Ｏ−Ｔ８８６、−ＯＣ（Ｏ）−ＮＨＴ８８７、−Ｏ−Ｃ（Ｏ）−ＮＴ８８８Ｔ８８９、−ＯＰ（Ｏ）（ＯＴ８９０）（ＯＴ８９１）、−ＯＳｉ（Ｔ８９２）（Ｔ８９３）（Ｔ８９４）、−ＯＳ（Ｏ₂）−Ｔ８９５、−ＮＨＣ（Ｏ）−Ｔ８９６、−ＮＴ８９７Ｃ（Ｏ）−Ｔ８９８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ８９９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ９００、−ＮＨ−Ｃ（Ｏ）−ＮＴ９０１Ｔ９０２、−ＮＴ９０３−Ｃ（Ｏ）−Ｏ−Ｔ９０４、−ＮＴ９０５−Ｃ（Ｏ）−ＮＨ−Ｔ９０６、−ＮＴ９０７−Ｃ（Ｏ）−ＮＴ９０８Ｔ９０９、−ＮＨＳ（Ｏ₂）−Ｔ９１０、−ＮＴ９１１Ｓ（Ｏ₂）−Ｔ９１２、−Ｓ−Ｔ９１３、−Ｓ（Ｏ）−Ｔ９１４、−Ｓ（Ｏ₂）−Ｔ９１５、−Ｓ（Ｏ₂）ＮＨ−Ｔ９１６、−Ｓ（Ｏ₂）ＮＴ９１７Ｔ９１８、−Ｓ（Ｏ₂）Ｏ−Ｔ９１９、−Ｐ（Ｏ）（ＯＴ９２０）（ＯＴ９２１）、−Ｓｉ（Ｔ９２２）（Ｔ９２３）（Ｔ９２４）"；
その際、Ｔ８７３、Ｔ８７４、Ｔ８７５、Ｔ８７６、Ｔ８７７、Ｔ８７８、Ｔ８７９、Ｔ８８０、Ｔ８８１、Ｔ８８２、Ｔ８８３、Ｔ８８４、Ｔ８８５、Ｔ８８６、Ｔ８８７、Ｔ８８８、Ｔ８８９、Ｔ８９０、Ｔ８９１、Ｔ８９２、Ｔ８９３、Ｔ８９４、Ｔ８９５、Ｔ８９６、Ｔ８９７、Ｔ８９８、Ｔ８９９、Ｔ９００、Ｔ９０１、Ｔ９０２、Ｔ９０３、Ｔ９０４、Ｔ９０５、Ｔ９０６、Ｔ９０７、Ｔ９０８、Ｔ９０９、Ｔ９１０、Ｔ９１１、Ｔ９１２、Ｔ９１３、Ｔ９１４、Ｔ９１５、Ｔ９１６、Ｔ９１７、Ｔ９１８、Ｔ９１９、Ｔ９２０、Ｔ９２１、Ｔ９２２、Ｔ９２３、Ｔ９２４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ８７９、Ｔ８８０及び／又はＴ８８８、Ｔ８８９及び／又はＴ９０１、Ｔ９０２及び／又はＴ９０８、Ｔ９０９及び／又はＴ９１７、Ｔ９１８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ９２５、−ＮＴ９２６Ｔ９２７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ９２８、−Ｃ（Ｏ）Ｏ−Ｔ９２９、−Ｃ（Ｏ）ＮＨ−Ｔ９３０、−Ｃ（Ｏ）ＮＴ９３１Ｔ９３２、−Ｏ−Ｔ９３３、−Ｏ（−Ｔ９３４−Ｏ）_i−Ｈ（ｉ＝１、２、３、４、５）、−Ｏ（−Ｔ９３５−Ｏ）_i−Ｔ９３６（ｉ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ９３７、−ＯＣ（Ｏ）−Ｏ−Ｔ９３８、−ＯＣ（Ｏ）−ＮＨＴ９３９、−Ｏ−Ｃ（Ｏ）−ＮＴ９４０Ｔ９４１、−ＯＰ（Ｏ）（ＯＴ９４２）（ＯＴ９４３）、−ＯＳｉ（Ｔ９４４）（Ｔ９４５）（Ｔ９４６）、−ＯＳ（Ｏ₂）−Ｔ９４７、−ＮＨＣ（Ｏ）−Ｔ９４８、−ＮＴ９４９Ｃ（Ｏ）−Ｔ９５０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ９５１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ９５２、−ＮＨ−Ｃ（Ｏ）−ＮＴ９５３Ｔ９５４、−ＮＴ９５５−Ｃ（Ｏ）−Ｏ−Ｔ９５６、−ＮＴ９５７−Ｃ（Ｏ）−ＮＨ−Ｔ９５８、−ＮＴ９５９−Ｃ（Ｏ）−ＮＴ９６０Ｔ９６１、−ＮＨＳ（Ｏ₂）−Ｔ９６２、−ＮＴ９６３Ｓ（Ｏ₂）−Ｔ９６４、−Ｓ−Ｔ９６５、−Ｓ（Ｏ）−Ｔ９６６、−Ｓ（Ｏ₂）−Ｔ９６７、−Ｓ（Ｏ₂）ＮＨ−Ｔ９６８、−Ｓ（Ｏ₂）ＮＴ９６９Ｔ９７０、−Ｓ（Ｏ₂）Ｏ−Ｔ９７１、−Ｐ（Ｏ）（ＯＴ９７２）（ＯＴ９７３）、−Ｓｉ（Ｔ９７４）（Ｔ９７５）（Ｔ９７６）"；
その際、Ｔ９２５、Ｔ９２６、Ｔ９２７、Ｔ９２８、Ｔ９２９、Ｔ９３０、Ｔ９３１、Ｔ９３２、Ｔ９３３、Ｔ９３４、Ｔ９３５、Ｔ９３６、Ｔ９３７、Ｔ９３８、Ｔ９３９、Ｔ９４０、Ｔ９４１、Ｔ９４２、Ｔ９４３、Ｔ９４４、Ｔ９４５、Ｔ９４６、Ｔ９４７、Ｔ９４８、Ｔ９４９、Ｔ９５０、Ｔ９５１、Ｔ９５２、Ｔ９５３、Ｔ９５４、Ｔ９５５、Ｔ９５６、Ｔ９５７、Ｔ９５８、Ｔ９５９、Ｔ９６０、Ｔ９６１、Ｔ９６２、Ｔ９６３、Ｔ９６４、Ｔ９６５、Ｔ９６６、Ｔ９６７、Ｔ９６８、Ｔ９６９、Ｔ９７０、Ｔ９７１、Ｔ９７２、Ｔ９７３、Ｔ９７４、Ｔ９７５、Ｔ９７６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ９３１、Ｔ９３２及び／又はＴ９４０、Ｔ９４１及び／又はＴ９５３、Ｔ９５４及び／又はＴ９６０、Ｔ９６１及び／又はＴ９６９、Ｔ９７０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ２６、Ｚ２７の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ２６、Ｚ２７のどちらも、以下のものからなる群から選択されない：
（３）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｃ（Ｙ７）ＮＺ３６Ｚ３７、−Ｃ（＝ＮＺ３８）−Ｚ３９、−Ｓ（Ｏ₂）−アルキル、−Ｓ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−アリール、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル"；
その際、Ｙ７は、互いに無関係に、"Ｏ、Ｓ、＝ＮＨ、＝ＮＺ４０"からなる群から選択される；
その際、基Ｚ３６、Ｚ３７、Ｚ３８、Ｚ３９、Ｚ４０は、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）−アルキル、−Ｓ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−アリール、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル"；
その際、場合により、置換基群（３）及び／又は置換基群（Ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ９７７、−ＮＴ９７８Ｔ９７９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ９８０、−Ｃ（Ｏ）Ｏ−Ｔ９８１、−Ｃ（Ｏ）ＮＨ−Ｔ９８２、−Ｃ（Ｏ）ＮＴ９８３Ｔ９８４、−Ｏ−Ｔ９８５、−Ｏ（−Ｔ９８６−Ｏ）_j−Ｈ（ｊ＝１、２、３、４、５）、−Ｏ（−Ｔ９８７−Ｏ）_j−Ｔ９８８（ｊ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ９８９、−ＯＣ（Ｏ）−Ｏ−Ｔ９９０、−ＯＣ（Ｏ）−ＮＨＴ９９１、−Ｏ−Ｃ（Ｏ）−ＮＴ９９２Ｔ９９３、−ＯＰ（Ｏ）（ＯＴ９９４）（ＯＴ９９５）、−ＯＳｉ（Ｔ９９６）（Ｔ９９７）（Ｔ９９８）、−ＯＳ（Ｏ₂）−Ｔ９９９、−ＮＨＣ（Ｏ）−Ｔ１０００、−ＮＴ１００１Ｃ（Ｏ）−Ｔ１００２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１００３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１００４、−ＮＨ−Ｃ（Ｏ）−ＮＴ１００５Ｔ１００６、−ＮＴ１００７−Ｃ（Ｏ）−Ｏ−Ｔ１００８、−ＮＴ１００９−Ｃ（Ｏ）−ＮＨ−Ｔ１０１０、−ＮＴ１０１１−Ｃ（Ｏ）−ＮＴ１０１２Ｔ１０１３、−ＮＨＳ（Ｏ₂）−Ｔ１０１４、−ＮＴ１０１５Ｓ（Ｏ₂）−Ｔ１０１６、−Ｓ−Ｔ１０１７、−Ｓ（Ｏ）−Ｔ１０１８、−Ｓ（Ｏ₂）−Ｔ１０１９、−Ｓ（Ｏ₂）ＮＨ−Ｔ１０２０、−Ｓ（Ｏ₂）ＮＴ１０２１Ｔ１０２２、−Ｓ（Ｏ₂）Ｏ−Ｔ１０２３、−Ｐ（Ｏ）（ＯＴ１０２４）（ＯＴ１０２５）、−Ｓｉ（Ｔ１０２６）（Ｔ１０２７）（Ｔ１０２８）"；
その際、Ｔ９７７、Ｔ９７８、Ｔ９７９、Ｔ９８０、Ｔ９８１、Ｔ９８２、Ｔ９８３、Ｔ９８４、Ｔ９８５、Ｔ９８６、Ｔ９８７、Ｔ９８８、Ｔ９８９、Ｔ９９０、Ｔ９９１、Ｔ９９２、Ｔ９９３、Ｔ９９４、Ｔ９９５、Ｔ９９６、Ｔ９９７、Ｔ９９８、Ｔ９９９、Ｔ１０００、Ｔ１００１、Ｔ１００２、Ｔ１００３、Ｔ１００４、Ｔ１００５、Ｔ１００６、Ｔ１００７、Ｔ１００８、Ｔ１００９、Ｔ１０１０、Ｔ１０１１、Ｔ１０１２、Ｔ１０１３、Ｔ１０１４、Ｔ１０１５、Ｔ１０１６、Ｔ１０１７、Ｔ１０１８、Ｔ１０１９、Ｔ１０２０、Ｔ１０２１、Ｔ１０２２、Ｔ１０２３、Ｔ１０２４、Ｔ１０２５、Ｔ１０２６、Ｔ１０２７、Ｔ１０２８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ９８３、Ｔ９８４及び／又はＴ９９２、Ｔ９９３及び／又はＴ１００５、Ｔ１００６及び／又はＴ１０１２、Ｔ１０１３及び／又はＴ１０２１、Ｔ１０２２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１０２９、−ＮＴ１０３０Ｔ１０３１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１０３２、−Ｃ（Ｏ）Ｏ−Ｔ１０３３、−Ｃ（Ｏ）ＮＨ−Ｔ１０３４、−Ｃ（Ｏ）ＮＴ１０３５Ｔ１０３６、−Ｏ−Ｔ１０３７、−Ｏ（−Ｔ１０３８−Ｏ）_k−Ｈ（ｋ＝１、２、３、４、５）、−Ｏ（−Ｔ１０３９−Ｏ）_k−Ｔ１０４０（ｋ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１０４１、−ＯＣ（Ｏ）−Ｏ−Ｔ１０４２、−ＯＣ（Ｏ）−ＮＨＴ１０４３、−Ｏ−Ｃ（Ｏ）−ＮＴ１０４４Ｔ１０４５、−ＯＰ（Ｏ）（ＯＴ１０４６）（ＯＴ１０４７）、−ＯＳｉ（Ｔ１０４８）（Ｔ１０４９）（Ｔ１０５０）、−ＯＳ（Ｏ₂）−Ｔ１０５１、−ＮＨＣ（Ｏ）−Ｔ１０５２、−ＮＴ１０５３Ｃ（Ｏ）−Ｔ１０５４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１０５５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１０５６、−ＮＨ−Ｃ（Ｏ）−ＮＴ１０５７Ｔ１０５８、−ＮＴ１０５９−Ｃ（Ｏ）−Ｏ−Ｔ１０６０、−ＮＴ１０６１−Ｃ（Ｏ）−ＮＨ−Ｔ１０６２、−ＮＴ１０６３−Ｃ（Ｏ）−ＮＴ１０６４Ｔ１０６５、−ＮＨＳ（Ｏ₂）−Ｔ１０６６、−ＮＴ１０６７Ｓ（Ｏ₂）−Ｔ１０６８、−Ｓ−Ｔ１０６９、−Ｓ（Ｏ）−Ｔ１０７０、−Ｓ（Ｏ₂）−Ｔ１０７１、−Ｓ（Ｏ₂）ＮＨ−Ｔ１０７２、−Ｓ（Ｏ₂）ＮＴ１０７３Ｔ１０７４、−Ｓ（Ｏ₂）Ｏ−Ｔ１０７５、−Ｐ（Ｏ）（ＯＴ１０７６）（ＯＴ１０７７）、−Ｓｉ（Ｔ１０７８）（Ｔ１０７９）（Ｔ１０８０）"；
その際、Ｔ１０２９、Ｔ１０３０、Ｔ１０３１、Ｔ１０３２、Ｔ１０３３、Ｔ１０３４、Ｔ１０３５、Ｔ１０３６、Ｔ１０３７、Ｔ１０３８、Ｔ１０３９、Ｔ１０４０、Ｔ１０４１、Ｔ１０４２、Ｔ１０４３、Ｔ１０４４、Ｔ１０４５、Ｔ１０４６、Ｔ１０４７、Ｔ１０４８、Ｔ１０４９、Ｔ１０５０、Ｔ１０５１、Ｔ１０５２、Ｔ１０５３、Ｔ１０５４、Ｔ１０５５、Ｔ１０５６、Ｔ１０５７、Ｔ１０５８、Ｔ１０５９、Ｔ１０６０、Ｔ１０６１、Ｔ１０６２、Ｔ１０６３、Ｔ１０６４、Ｔ１０６５、Ｔ１０６６、Ｔ１０６７、Ｔ１０６８、Ｔ１０６９、Ｔ１０７０、Ｔ１０７１、Ｔ１０７２、Ｔ１０７３、Ｔ１０７４、Ｔ１０７５、Ｔ１０７６、Ｔ１０７７、Ｔ１０７８、Ｔ１０７９、Ｔ１０８０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１０３５、Ｔ１０３６及び／又はＴ１０４４、Ｔ１０４５及び／又はＴ１０５７、Ｔ１０５８及び／又はＴ１０６４、Ｔ１０６５及び／又はＴ１０７３、Ｔ１０７４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１０８１、−ＮＴ１０８２Ｔ１０８３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１０８４、−Ｃ（Ｏ）Ｏ−Ｔ１０８５、−Ｃ（Ｏ）ＮＨ−Ｔ１０８６、−Ｃ（Ｏ）ＮＴ１０８７Ｔ１０８８、−Ｏ−Ｔ１０８９、−Ｏ（−Ｔ１０９０−Ｏ）_l−Ｈ（ｌ＝１、２、３、４、５）、−Ｏ（−Ｔ１０９１−Ｏ）_l−Ｔ１０９２（ｌ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１０９３、−ＯＣ（Ｏ）−Ｏ−Ｔ１０９４、−ＯＣ（Ｏ）−ＮＨＴ１０９５、−Ｏ−Ｃ（Ｏ）−ＮＴ１０９６Ｔ１０９７、−ＯＰ（Ｏ）（ＯＴ１０９８）（ＯＴ１０９９）、−ＯＳｉ（Ｔ１１００）（Ｔ１１０１）（Ｔ１１０２）、−ＯＳ（Ｏ₂）−Ｔ１１０３、−ＮＨＣ（Ｏ）−Ｔ１１０４、−ＮＴ１１０５Ｃ（Ｏ）−Ｔ１１０６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１１０７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１１０８、−ＮＨ−Ｃ（Ｏ）−ＮＴ１１０９Ｔ１１１０、−ＮＴ１１１１−Ｃ（Ｏ）−Ｏ−Ｔ１１１２、−ＮＴ１１１３−Ｃ（Ｏ）−ＮＨ−Ｔ１１１４、−ＮＴ１１１５−Ｃ（Ｏ）−ＮＴ１１１６Ｔ１１１７、−ＮＨＳ（Ｏ₂）−Ｔ１１１８、−ＮＴ１１１９Ｓ（Ｏ₂）−Ｔ１１２０、−Ｓ−Ｔ１１２１、−Ｓ（Ｏ）−Ｔ１１２２、−Ｓ（Ｏ₂）−Ｔ１１２３、−Ｓ（Ｏ₂）ＮＨ−Ｔ１１２４、−Ｓ（Ｏ₂）ＮＴ１１２５Ｔ１１２６、−Ｓ（Ｏ₂）Ｏ−Ｔ１１２７、−Ｐ（Ｏ）（ＯＴ１１２８）（ＯＴ１１２９）、−Ｓｉ（Ｔ１１３０）（Ｔ１１３１）（Ｔ１１３２）"；
その際、Ｔ１０８１、Ｔ１０８２、Ｔ１０８３、Ｔ１０８４、Ｔ１０８５、Ｔ１０８６、Ｔ１０８７、Ｔ１０８８、Ｔ１０８９、Ｔ１０９０、Ｔ１０９１、Ｔ１０９２、Ｔ１０９３、Ｔ１０９４、Ｔ１０９５、Ｔ１０９６、Ｔ１０９７、Ｔ１０９８、Ｔ１０９９、Ｔ１１００、Ｔ１１０１、Ｔ１１０２、Ｔ１１０３、Ｔ１１０４、Ｔ１１０５、Ｔ１１０６、Ｔ１１０７、Ｔ１１０８、Ｔ１１０９、Ｔ１１１０、Ｔ１１１１、Ｔ１１１２、Ｔ１１１３、Ｔ１１１４、Ｔ１１１５、Ｔ１１１６、Ｔ１１１７、Ｔ１１１８、Ｔ１１１９、Ｔ１１２０、Ｔ１１２１、Ｔ１１２２、Ｔ１１２３、Ｔ１１２４、Ｔ１１２５、Ｔ１１２６、Ｔ１１２７、Ｔ１１２８、Ｔ１１２９、Ｔ１１３０、Ｔ１１３１、Ｔ１１３２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１０８７、Ｔ１０８８及び／又はＴ１０９６、Ｔ１０９７及び／又はＴ１１０９、Ｔ１１１０及び／又はＴ１１１６、Ｔ１１１７及び／又はＴ１１２５、Ｔ１１２６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ１、Ｚ２の一方は、互いに無関係に、以下のものからなる群から選択されるか、もしくは基Ｚ１、Ｚ２のどちらも、以下のものからなる群から選択されない：
（ｃ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１１３３、−ＮＴ１１３４Ｔ１１３５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１１３６、−Ｃ（Ｏ）Ｏ−Ｔ１１３７、−Ｃ（Ｏ）ＮＨ−Ｔ１１３８、−Ｃ（Ｏ）ＮＴ１１３９Ｔ１１４０、−Ｏ−Ｔ１１４１、−Ｏ（−Ｔ１１４２−Ｏ）_m−Ｈ（ｍ＝１、２、３、４、５）、−Ｏ（−Ｔ１１４３−Ｏ）_m−Ｔ１１４４（ｍ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１１４５、−ＯＣ（Ｏ）−Ｏ−Ｔ１１４６、−ＯＣ（Ｏ）−ＮＨＴ１１４７、−Ｏ−Ｃ（Ｏ）−ＮＴ１１４８Ｔ１１４９、−ＯＰ（Ｏ）（ＯＴ１１５０）（ＯＴ１１５１）、−ＯＳｉ（Ｔ１１５２）（Ｔ１１５３）（Ｔ１１５４）、−ＯＳ（Ｏ₂）−Ｔ１１５５、−ＮＨＣ（Ｏ）−Ｔ１１５６、−ＮＴ１１５７Ｃ（Ｏ）−Ｔ１１５８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１１５９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１１６０、−ＮＨ−Ｃ（Ｏ）−ＮＴ１１６１Ｔ１１６２、−ＮＴ１１６３−Ｃ（Ｏ）−Ｏ−Ｔ１１６４、−ＮＴ１１６５−Ｃ（Ｏ）−ＮＨ−Ｔ１１６６、−ＮＴ１１６７−Ｃ（Ｏ）−ＮＴ１１６８Ｔ１１６９、−ＮＨＳ（Ｏ₂）−Ｔ１１７０、−ＮＴ１１７１Ｓ（Ｏ₂）−Ｔ１１７２、−Ｓ−Ｔ１１７３、−Ｓ（Ｏ）−Ｔ１１７４、−Ｓ（Ｏ₂）−Ｔ１１７５、−Ｓ（Ｏ₂）ＮＨ−Ｔ１１７６、−Ｓ（Ｏ₂）ＮＴ１１７７Ｔ１１７８、−Ｓ（Ｏ₂）Ｏ−Ｔ１１７９、−Ｐ（Ｏ）（ＯＴ１１８０）（ＯＴ１１８１）、−Ｓｉ（Ｔ１１８２）（Ｔ１１８３）（Ｔ１１８４）"；
その際、Ｔ１１３３、Ｔ１１３４、Ｔ１１３５、Ｔ１１３６、Ｔ１１３７、Ｔ１１３８、Ｔ１１３９、Ｔ１１４０、Ｔ１１４１、Ｔ１１４２、Ｔ１１４３、Ｔ１１４４、Ｔ１１４５、Ｔ１１４６、Ｔ１１４７、Ｔ１１４８、Ｔ１１４９、Ｔ１１５０、Ｔ１１５１、Ｔ１１５２、Ｔ１１５３、Ｔ１１５４、Ｔ１１５５、Ｔ１１５６、Ｔ１１５７、Ｔ１１５８、Ｔ１１５９、Ｔ１１６０、Ｔ１１６１、Ｔ１１６２、Ｔ１１６３、Ｔ１１６４、Ｔ１１６５、Ｔ１１６６、Ｔ１１６７、Ｔ１１６８、Ｔ１１６９、Ｔ１１７０、Ｔ１１７１、Ｔ１１７２、Ｔ１１７３、Ｔ１１７４、Ｔ１１７５、Ｔ１１７６、Ｔ１１７７、Ｔ１１７８、Ｔ１１７９、Ｔ１１８０、Ｔ１１８１、Ｔ１１８２、Ｔ１１８３、Ｔ１１８４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１１３９、Ｔ１１４０及び／又はＴ１１４８、Ｔ１１４９及び／又はＴ１１６１、Ｔ１１６２及び／又はＴ１１６８、Ｔ１１６９及び／又はＴ１１７７、Ｔ１１７８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｃ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１１８５、−ＮＴ１１８６Ｔ１１８７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１１８８、−Ｃ（Ｏ）Ｏ−Ｔ１１８９、−Ｃ（Ｏ）ＮＨ−Ｔ１１９０、−Ｃ（Ｏ）ＮＴ１１９１Ｔ１１９２、−Ｏ−Ｔ１１９３、−Ｏ（−Ｔ１１９４−Ｏ）_n−Ｈ（ｎ＝１、２、３、４、５）、−Ｏ（−Ｔ１１９５−Ｏ）_n−Ｔ１１９６（ｎ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１１９７、−ＯＣ（Ｏ）−Ｏ−Ｔ１１９８、−ＯＣ（Ｏ）−ＮＨＴ１１９９、−Ｏ−Ｃ（Ｏ）−ＮＴ１２００Ｔ１２０１、−ＯＰ（Ｏ）（ＯＴ１２０２）（ＯＴ１２０３）、−ＯＳｉ（Ｔ１２０４）（Ｔ１２０５）（Ｔ１２０６）、−ＯＳ（Ｏ₂）−Ｔ１２０７、−ＮＨＣ（Ｏ）−Ｔ１２０８、−ＮＴ１２０９Ｃ（Ｏ）−Ｔ１２１０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１２１１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１２１２、−ＮＨ−Ｃ（Ｏ）−ＮＴ１２１３Ｔ１２１４、−ＮＴ１２１５−Ｃ（Ｏ）−Ｏ−Ｔ１２１６、−ＮＴ１２１７−Ｃ（Ｏ）−ＮＨ−Ｔ１２１８、−ＮＴ１２１９−Ｃ（Ｏ）−ＮＴ１２２０Ｔ１２２１、−ＮＨＳ（Ｏ₂）−Ｔ１２２２、−ＮＴ１２２３Ｓ（Ｏ₂）−Ｔ１２２４、−Ｓ−Ｔ１２２５、−Ｓ（Ｏ）−Ｔ１２２６、−Ｓ（Ｏ₂）−Ｔ１２２７、−Ｓ（Ｏ₂）ＮＨ−Ｔ１２２８、−Ｓ（Ｏ₂）ＮＴ１２２９Ｔ１２３０、−Ｓ（Ｏ₂）Ｏ−Ｔ１２３１、−Ｐ（Ｏ）（ＯＴ１２３２）（ＯＴ１２３３）、−Ｓｉ（Ｔ１２３４）（Ｔ１２３５）（Ｔ１２３６）"；
その際、Ｔ１１８５、Ｔ１１８６、Ｔ１１８７、Ｔ１１８８、Ｔ１１８９、Ｔ１１９０、Ｔ１１９１、Ｔ１１９２、Ｔ１１９３、Ｔ１１９４、Ｔ１１９５、Ｔ１１９６、Ｔ１１９７、Ｔ１１９８、Ｔ１１９９、Ｔ１２００、Ｔ１２０１、Ｔ１２０２、Ｔ１２０３、Ｔ１２０４、Ｔ１２０５、Ｔ１２０６、Ｔ１２０７、Ｔ１２０８、Ｔ１２０９、Ｔ１２１０、Ｔ１２１１、Ｔ１２１２、Ｔ１２１３、Ｔ１２１４、Ｔ１２１５、Ｔ１２１６、Ｔ１２１７、Ｔ１２１８、Ｔ１２１９、Ｔ１２２０、Ｔ１２２１、Ｔ１２２２、Ｔ１２２３、Ｔ１２２４、Ｔ１２２５、Ｔ１２２６、Ｔ１２２７、Ｔ１２２８、Ｔ１２２９、Ｔ１２３０、Ｔ１２３１、Ｔ１２３２、Ｔ１２３３、Ｔ１２３４、Ｔ１２３５、Ｔ１２３６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１１９１、Ｔ１１９２及び／又はＴ１２００、Ｔ１２０１及び／又はＴ１２１３、Ｔ１２１４及び／又はＴ１２２０、Ｔ１２２１及び／又はＴ１２２９、Ｔ１２３０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１２３７、−ＮＴ１２３８Ｔ１２３９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１２４０、−Ｃ（Ｏ）Ｏ−Ｔ１２４１、−Ｃ（Ｏ）ＮＨ−Ｔ１２４２、−Ｃ（Ｏ）ＮＴ１２４３Ｔ１２４４、−Ｏ−Ｔ１２４５、−Ｏ（−Ｔ１２４６−Ｏ）_o−Ｈ（ｏ＝１、２、３、４、５）、−Ｏ（−Ｔ１２４７−Ｏ）_o−Ｔ１２４８（ｏ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１２４９、−ＯＣ（Ｏ）−Ｏ−Ｔ１２５０、−ＯＣ（Ｏ）−ＮＨＴ１２５１、−Ｏ−Ｃ（Ｏ）−ＮＴ１２５２Ｔ１２５３、−ＯＰ（Ｏ）（ＯＴ１２５４）（ＯＴ１２５５）、−ＯＳｉ（Ｔ１２５６）（Ｔ１２５７）（Ｔ１２５８）、−ＯＳ（Ｏ₂）−Ｔ１２５９、−ＮＨＣ（Ｏ）−Ｔ１２６０、−ＮＴ１２６１Ｃ（Ｏ）−Ｔ１２６２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１２６３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１２６４、−ＮＨ−Ｃ（Ｏ）−ＮＴ１２６５Ｔ１２６６、−ＮＴ１２６７−Ｃ（Ｏ）−Ｏ−Ｔ１２６８、−ＮＴ１２６９−Ｃ（Ｏ）−ＮＨ−Ｔ１２７０、−ＮＴ１２７１−Ｃ（Ｏ）−ＮＴ１２７２Ｔ１２７３、−ＮＨＳ（Ｏ₂）−Ｔ１２７４、−ＮＴ１２７５Ｓ（Ｏ₂）−Ｔ１２７６、−Ｓ−Ｔ１２７７、−Ｓ（Ｏ）−Ｔ１２７８、−Ｓ（Ｏ₂）−Ｔ１２７９、−Ｓ（Ｏ₂）ＮＨ−Ｔ１２８０、−Ｓ（Ｏ₂）ＮＴ１２８１Ｔ１２８２、−Ｓ（Ｏ₂）Ｏ−Ｔ１２８３、−Ｐ（Ｏ）（ＯＴ１２８４）（ＯＴ１２８５）、−Ｓｉ（Ｔ１２８６）（Ｔ１２８７）（Ｔ１２８８）"；
その際、Ｔ１２３７、Ｔ１２３８、Ｔ１２３９、Ｔ１２４０、Ｔ１２４１、Ｔ１２４２、Ｔ１２４３、Ｔ１２４４、Ｔ１２４５、Ｔ１２４６、Ｔ１２４７、Ｔ１２４８、Ｔ１２４９、Ｔ１２５０、Ｔ１２５１、Ｔ１２５２、Ｔ１２５３、Ｔ１２５４、Ｔ１２５５、Ｔ１２５６、Ｔ１２５７、Ｔ１２５８、Ｔ１２５９、Ｔ１２６０、Ｔ１２６１、Ｔ１２６２、Ｔ１２６３、Ｔ１２６４、Ｔ１２６５、Ｔ１２６６、Ｔ１２６７、Ｔ１２６８、Ｔ１２６９、Ｔ１２７０、Ｔ１２７１、Ｔ１２７２、Ｔ１２７３、Ｔ１２７４、Ｔ１２７５、Ｔ１２７６、Ｔ１２７７、Ｔ１２７８、Ｔ１２７９、Ｔ１２８０、Ｔ１２８１、Ｔ１２８２、Ｔ１２８３、Ｔ１２８４、Ｔ１２８５、Ｔ１２８６、Ｔ１２８７、Ｔ１２８８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１２４３、Ｔ１２４４及び／又はＴ１２５２、Ｔ１２５３及び／又はＴ１２６５、Ｔ１２６６及び／又はＴ１２７２、Ｔ１２７３及び／又はＴ１２８１、Ｔ１２８２は、一緒になって、"ヘテロシクリル"を形成することもできる；
（ｄ）−ＮＺ４１Ｚ４２、
その際、基Ｚ４１、Ｚ４２は、互いに無関係に、以下のものからなる群から選択される：
（１）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−ヘテロシクリルアルキル"；
その際、場合により、置換基群（１）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１２８９、−ＮＴ１２９０Ｔ１２９１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１２９２、−Ｃ（Ｏ）Ｏ−Ｔ１２９３、−Ｃ（Ｏ）ＮＨ−Ｔ１２９４、−Ｃ（Ｏ）ＮＴ１２９５Ｔ１２９６、−Ｏ−Ｔ１２９７、−Ｏ（−Ｔ１２９８−Ｏ）_rr−Ｈ（ｒｒ＝１、２、３、４、５）、−Ｏ（−Ｔ１２９９−Ｏ）_rr−Ｔ１３００（ｒｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１３０１、−ＯＣ（Ｏ）−Ｏ−Ｔ１３０２、−ＯＣ（Ｏ）−ＮＨＴ１３０３、−Ｏ−Ｃ（Ｏ）−ＮＴ１３０４Ｔ１３０５、−ＯＰ（Ｏ）（ＯＴ１３０６）（ＯＴ１３０７）、−ＯＳｉ（Ｔ１３０８）（Ｔ１３０９）（Ｔ１３１０）、−ＯＳ（Ｏ₂）−Ｔ１３１１、−ＮＨＣ（Ｏ）−Ｔ１３１２、−ＮＴ１３１３Ｃ（Ｏ）−Ｔ１３１４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１３１５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１３１６、−ＮＨ−Ｃ（Ｏ）−ＮＴ１３１７Ｔ１３１８、−ＮＴ１３１９−Ｃ（Ｏ）−Ｏ−Ｔ１３２０、−ＮＴ１３２１−Ｃ（Ｏ）−ＮＨ−Ｔ１３２２、−ＮＴ１３２３−Ｃ（Ｏ）−ＮＴ１３２４Ｔ１３２５、−ＮＨＳ（Ｏ₂）−Ｔ１３２６、−ＮＴ１３２７Ｓ（Ｏ₂）−Ｔ１３２８、−Ｓ−Ｔ１３２９、−Ｓ（Ｏ）−Ｔ１３３０、−Ｓ（Ｏ₂）−Ｔ１３３１、−Ｓ（Ｏ₂）ＮＨ−Ｔ１３３２、−Ｓ（Ｏ₂）ＮＴ１３３３Ｔ１３３４、−Ｓ（Ｏ₂）Ｏ−Ｔ１３３５、−Ｐ（Ｏ）（ＯＴ１３３６）（ＯＴ１３３７）、−Ｓｉ（Ｔ１３３８）（Ｔ１３３９）（Ｔ１３４０）"；
その際、Ｔ１２８９、Ｔ１２９０、Ｔ１２９１、Ｔ１２９２、Ｔ１２９３、Ｔ１２９４、Ｔ１２９５、Ｔ１２９６、Ｔ１２９７、Ｔ１２９８、Ｔ１２９９、Ｔ１３００、Ｔ１３０１、Ｔ１３０２、Ｔ１３０３、Ｔ１３０４、Ｔ１３０５、Ｔ１３０６、Ｔ１３０７、Ｔ１３０８、Ｔ１３０９、Ｔ１３１０、Ｔ１３１１、Ｔ１３１２、Ｔ１３１３、Ｔ１３１４、Ｔ１３１５、Ｔ１３１６、Ｔ１３１７、Ｔ１３１８、Ｔ１３１９、Ｔ１３２０、Ｔ１３２１、Ｔ１３２２、Ｔ１３２３、Ｔ１３２４、Ｔ１３２５、Ｔ１３２６、Ｔ１３２７、Ｔ１３２８、Ｔ１３２９、Ｔ１３３０、Ｔ１３３１、Ｔ１３３２、Ｔ１３３３、Ｔ１３３４、Ｔ１３３５、Ｔ１３３６、Ｔ１３３７、Ｔ１３３８、Ｔ１３３９、Ｔ１３４０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１２９５、Ｔ１２９６及び／又はＴ１３０４、Ｔ１３０５及び／又はＴ１３１７、Ｔ１３１８及び／又はＴ１３２４、Ｔ１３２５及び／又はＴ１３３３、Ｔ１３３４は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１３４１、−ＮＴ１３４２Ｔ１３４３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１３４４、−Ｃ（Ｏ）Ｏ−Ｔ１３４５、−Ｃ（Ｏ）ＮＨ−Ｔ１３４６、−Ｃ（Ｏ）ＮＴ１３４７Ｔ１３４８、−Ｏ−Ｔ１３４９、−Ｏ（−Ｔ１３５０−Ｏ）_rs−Ｈ（ｒｓ＝１、２、３、４、５）、−Ｏ（−Ｔ１３５１−Ｏ）_rs−Ｔ１３５２（ｒｓ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１３５３、−ＯＣ（Ｏ）−Ｏ−Ｔ１３５４、−ＯＣ（Ｏ）−ＮＨＴ１３５５、−Ｏ−Ｃ（Ｏ）−ＮＴ１３５６Ｔ１３５７、−ＯＰ（Ｏ）（ＯＴ１３５８）（ＯＴ１３５９）、−ＯＳｉ（Ｔ１３６０）（Ｔ１３６１）（Ｔ１３６２）、−ＯＳ（Ｏ₂）−Ｔ１３６３、−ＮＨＣ（Ｏ）−Ｔ１３６４、−ＮＴ１３６５Ｃ（Ｏ）−Ｔ１３６６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１３６７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１３６８、−ＮＨ−Ｃ（Ｏ）−ＮＴ１３６９Ｔ１３７０、−ＮＴ１３７１−Ｃ（Ｏ）−Ｏ−Ｔ１３７２、−ＮＴ１３７３−Ｃ（Ｏ）−ＮＨ−Ｔ１３７４、−ＮＴ１３７５−Ｃ（Ｏ）−ＮＴ１３７６Ｔ１３７７、−ＮＨＳ（Ｏ₂）−Ｔ１３７８、−ＮＴ１３７９Ｓ（Ｏ₂）−Ｔ１３８０、−Ｓ−Ｔ１３８１、−Ｓ（Ｏ）−Ｔ１３８２、−Ｓ（Ｏ₂）−Ｔ１３８３、−Ｓ（Ｏ₂）ＮＨ−Ｔ１３８４、−Ｓ（Ｏ₂）ＮＴ１３８５Ｔ１３８６、−Ｓ（Ｏ₂）Ｏ−Ｔ１３８７、−Ｐ（Ｏ）（ＯＴ１３８８）（ＯＴ１３８９）、−Ｓｉ（Ｔ１３９０）（Ｔ１３９１）（Ｔ１３９２）"；
その際、Ｔ１３４１、Ｔ１３４２、Ｔ１３４３、Ｔ１３４４、Ｔ１３４５、Ｔ１３４６、Ｔ１３４７、Ｔ１３４８、Ｔ１３４９、Ｔ１３５０、Ｔ１３５１、Ｔ１３５２、Ｔ１３５３、Ｔ１３５４、Ｔ１３５５、Ｔ１３５６、Ｔ１３５７、Ｔ１３５８、Ｔ１３５９、Ｔ１３６０、Ｔ１３６１、Ｔ１３６２、Ｔ１３６３、Ｔ１３６４、Ｔ１３６５、Ｔ１３６６、Ｔ１３６７、Ｔ１３６８、Ｔ１３６９、Ｔ１３７０、Ｔ１３７１、Ｔ１３７２、Ｔ１３７３、Ｔ１３７４、Ｔ１３７５、Ｔ１３７６、Ｔ１３７７、Ｔ１３７８、Ｔ１３７９、Ｔ１３８０、Ｔ１３８１、Ｔ１３８２、Ｔ１３８３、Ｔ１３８４、Ｔ１３８５、Ｔ１３８６、Ｔ１３８７、Ｔ１３８８、Ｔ１３８９、Ｔ１３９０、Ｔ１３９１、Ｔ１３９２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１３４７、Ｔ１３４８及び／又はＴ１３５６、Ｔ１３５７及び／又はＴ１３６９、Ｔ１３７０及び／又はＴ１３７６、Ｔ１３７７及び／又はＴ１３８５、Ｔ１３８６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１３９３、−ＮＴ１３９４Ｔ１３９５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１３９６、−Ｃ（Ｏ）Ｏ−Ｔ１３９７、−Ｃ（Ｏ）ＮＨ−Ｔ１３９８、−Ｃ（Ｏ）ＮＴ１３９９Ｔ１４００、−Ｏ−Ｔ１４０１、−Ｏ（−Ｔ１４０２−Ｏ）_rt−Ｈ（ｒｔ＝１、２、３、４、５）、−Ｏ（−Ｔ１４０３−Ｏ）_rt−Ｔ１４０４（ｒｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１４０５、−ＯＣ（Ｏ）−Ｏ−Ｔ１４０６、−ＯＣ（Ｏ）−ＮＨＴ１４０７、−Ｏ−Ｃ（Ｏ）−ＮＴ１４０８Ｔ１４０９、−ＯＰ（Ｏ）（ＯＴ１４１０）（ＯＴ１４１１）、−ＯＳｉ（Ｔ１４１２）（Ｔ１４１３）（Ｔ１４１４）、−ＯＳ（Ｏ₂）−Ｔ１４１５、−ＮＨＣ（Ｏ）−Ｔ１４１６、−ＮＴ１４１７Ｃ（Ｏ）−Ｔ１４１８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１４１９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１４２０、−ＮＨ−Ｃ（Ｏ）−ＮＴ１４２１Ｔ１４２２、−ＮＴ１４２３−Ｃ（Ｏ）−Ｏ−Ｔ１４２４、−ＮＴ１４２５−Ｃ（Ｏ）−ＮＨ−Ｔ１４２６、−ＮＴ１４２７−Ｃ（Ｏ）−ＮＴ１４２８Ｔ１４２９、−ＮＨＳ（Ｏ₂）−Ｔ１４３０、−ＮＴ１４３１Ｓ（Ｏ₂）−Ｔ１４３２、−Ｓ−Ｔ１４３３、−Ｓ（Ｏ）−Ｔ１４３４、−Ｓ（Ｏ₂）−Ｔ１４３５、−Ｓ（Ｏ₂）ＮＨ−Ｔ１４３６、−Ｓ（Ｏ₂）ＮＴ１４３７Ｔ１４３８、−Ｓ（Ｏ₂）Ｏ−Ｔ１４３９、−Ｐ（Ｏ）（ＯＴ１４４０）（ＯＴ１４４１）、−Ｓｉ（Ｔ１４４２）（Ｔ１４４３）（Ｔ１４４４）"；
その際、Ｔ１３９３、Ｔ１３９４、Ｔ１３９５、Ｔ１３９６、Ｔ１３９７、Ｔ１３９８、Ｔ１３９９、Ｔ１４００、Ｔ１４０１、Ｔ１４０２、Ｔ１４０３、Ｔ１４０４、Ｔ１４０５、Ｔ１４０６、Ｔ１４０７、Ｔ１４０８、Ｔ１４０９、Ｔ１４１０、Ｔ１４１１、Ｔ１４１２、Ｔ１４１３、Ｔ１４１４、Ｔ１４１５、Ｔ１４１６、Ｔ１４１７、Ｔ１４１８、Ｔ１４１９、Ｔ１４２０、Ｔ１４２１、Ｔ１４２２、Ｔ１４２３、Ｔ１４２４、Ｔ１４２５、Ｔ１４２６、Ｔ１４２７、Ｔ１４２８、Ｔ１４２９、Ｔ１４３０、Ｔ１４３１、Ｔ１４３２、Ｔ１４３３、Ｔ１４３４、Ｔ１４３５、Ｔ１４３６、Ｔ１４３７、Ｔ１４３８、Ｔ１４３９、Ｔ１４４０、Ｔ１４４１、Ｔ１４４２、Ｔ１４４３、Ｔ１４４４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１３９９、Ｔ１４００及び／又はＴ１４０８、Ｔ１４０９及び／又はＴ１４２１、Ｔ１４２２及び／又はＴ１４２８、Ｔ１４２９及び／又はＴ１４３７、Ｔ１４３８は、一緒になって、"ヘテロシクリル"を形成することもできる；
（２）"−Ｃ（Ｏ）−Ｃ（Ｏ）−Ｔ１４４５、−Ｓ（Ｏ₂）−ＮＴ１４４６Ｔ１４４７"；
その際、Ｔ１４４５、Ｔ１４４６、Ｔ１４４７は、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１４４８、−ＮＴ１４４９Ｔ１４５０、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１４５１、−Ｃ（Ｏ）Ｏ−Ｔ１４５２、−Ｃ（Ｏ）ＮＨ−Ｔ１４５３、−Ｃ（Ｏ）ＮＴ１４５４Ｔ１４５５、−Ｏ−Ｔ１４５６、−Ｏ（−Ｔ１４５７−Ｏ）_ru−Ｈ（ｒｕ＝１、２、３、４、５）、−Ｏ（−Ｔ１４５８−Ｏ）_ru−Ｔ１４５９（ｒｕ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１４６０、−ＯＣ（Ｏ）−Ｏ−Ｔ１４６１、−ＯＣ（Ｏ）−ＮＨＴ１４６２、−Ｏ−Ｃ（Ｏ）−ＮＴ１４６３Ｔ１４６４、−ＯＰ（Ｏ）（ＯＴ１４６５）（ＯＴ１４６６）、−ＯＳｉ（Ｔ１４６７）（Ｔ１４６８）（Ｔ１４６９）、−ＯＳ（Ｏ₂）−Ｔ１４７０、−ＮＨＣ（Ｏ）−Ｔ１４７１、−ＮＴ１４７２Ｃ（Ｏ）−Ｔ１４７３、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１４７４、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１４７５、−ＮＨ−Ｃ（Ｏ）−ＮＴ１４７６Ｔ１４７７、−ＮＴ１４７８−Ｃ（Ｏ）−Ｏ−Ｔ１４７９、−ＮＴ１４８０−Ｃ（Ｏ）−ＮＨ−Ｔ１４８１、−ＮＴ１４８２−Ｃ（Ｏ）−ＮＴ１４８３Ｔ１４８４、−ＮＨＳ（Ｏ₂）−Ｔ１４８５、−ＮＴ１４８６Ｓ（Ｏ₂）−Ｔ１４８７、−Ｓ−Ｔ１４８８、−Ｓ（Ｏ）−Ｔ１４８９、−Ｓ（Ｏ₂）−Ｔ１４９０、−Ｓ（Ｏ₂）ＮＨ−Ｔ１４９１、−Ｓ（Ｏ₂）ＮＴ１４９２Ｔ１４９３、−Ｓ（Ｏ₂）Ｏ−Ｔ１４９４、−Ｐ（Ｏ）（ＯＴ１４９５）（ＯＴ１４９６）、−Ｓｉ（Ｔ１４９７）（Ｔ１４９８）（Ｔ１４９９）"；
その際、Ｔ１４４８、Ｔ１４４９、Ｔ１４５０、Ｔ１４５１、Ｔ１４５２、Ｔ１４５３、Ｔ１４５４、Ｔ１４５５、Ｔ１４５６、Ｔ１４５７、Ｔ１４５８、Ｔ１４５９、Ｔ１４６０、Ｔ１４６１、Ｔ１４６２、Ｔ１４６３、Ｔ１４６４、Ｔ１４６５、Ｔ１４６６、Ｔ１４６７、Ｔ１４６８、Ｔ１４６９、Ｔ１４７０、Ｔ１４７１、Ｔ１４７２、Ｔ１４７３、Ｔ１４７４、Ｔ１４７５、Ｔ１４７６、Ｔ１４７７、Ｔ１４７８、Ｔ１４７９、Ｔ１４８０、Ｔ１４８１、Ｔ１４８２、Ｔ１４８３、Ｔ１４８４、Ｔ１４８５、Ｔ１４８６、Ｔ１４８７、Ｔ１４８８、Ｔ１４８９、Ｔ１４９０、Ｔ１４９１、Ｔ１４９２、Ｔ１４９３、Ｔ１４９４、Ｔ１４９５、Ｔ１４９６、Ｔ１４９７、Ｔ１４９８、Ｔ１４９９は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１４５４、Ｔ１４５５及び／又はＴ１４６３、Ｔ１４６４及び／又はＴ１４７６、Ｔ１４７７及び／又はＴ１４８３、Ｔ１４８４及び／又はＴ１４９２、Ｔ１４９３は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（Ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１５００、−ＮＴ１５０１Ｔ１５０２、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１５０３、−Ｃ（Ｏ）Ｏ−Ｔ１５０４、−Ｃ（Ｏ）ＮＨ−Ｔ１５０５、−Ｃ（Ｏ）ＮＴ１５０６Ｔ１５０７、−Ｏ−Ｔ１５０８、−Ｏ（−Ｔ１５０９−Ｏ）_rv−Ｈ（ｒｖ＝１、２、３、４、５）、−Ｏ（−Ｔ１５１０−Ｏ）_rv−Ｔ１５１１（ｒｖ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１５１２、−ＯＣ（Ｏ）−Ｏ−Ｔ１５１３、−ＯＣ（Ｏ）−ＮＨＴ１５１４、−Ｏ−Ｃ（Ｏ）−ＮＴ１５１５Ｔ１５１６、−ＯＰ（Ｏ）（ＯＴ１５１７）（ＯＴ１５１８）、−ＯＳｉ（Ｔ１５１９）（Ｔ１５２０）（Ｔ１５２１）、−ＯＳ（Ｏ₂）−Ｔ１５２２、−ＮＨＣ（Ｏ）−Ｔ１５２３、−ＮＴ１５２４Ｃ（Ｏ）−Ｔ１５２５、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１５２６、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１５２７、−ＮＨ−Ｃ（Ｏ）−ＮＴ１５２８Ｔ１５２９、−ＮＴ１５３０−Ｃ（Ｏ）−Ｏ−Ｔ１５３１、−ＮＴ１５３２−Ｃ（Ｏ）−ＮＨ−Ｔ１５３３、−ＮＴ１５３４−Ｃ（Ｏ）−ＮＴ１５３５Ｔ１５３６、−ＮＨＳ（Ｏ₂）−Ｔ１５３７、−ＮＴ１５３８Ｓ（Ｏ₂）−Ｔ１５３９、−Ｓ−Ｔ１５４０、−Ｓ（Ｏ）−Ｔ１５４１、−Ｓ（Ｏ₂）−Ｔ１５４２、−Ｓ（Ｏ₂）ＮＨ−Ｔ１５４３、−Ｓ（Ｏ₂）ＮＴ１５４４Ｔ１５４５、−Ｓ（Ｏ₂）Ｏ−Ｔ１５４６、−Ｐ（Ｏ）（ＯＴ１５４７）（ＯＴ１５４８）、−Ｓｉ（Ｔ１５４９）（Ｔ１５５０）（Ｔ１５５１）"；
その際、Ｔ１５００、Ｔ１５０１、Ｔ１５０２、Ｔ１５０３、Ｔ１５０４、Ｔ１５０５、Ｔ１５０６、Ｔ１５０７、Ｔ１５０８、Ｔ１５０９、Ｔ１５１０、Ｔ１５１１、Ｔ１５１２、Ｔ１５１３、Ｔ１５１４、Ｔ１５１５、Ｔ１５１６、Ｔ１５１７、Ｔ１５１８、Ｔ１５１９、Ｔ１５２０、Ｔ１５２１、Ｔ１５２２、Ｔ１５２３、Ｔ１５２４、Ｔ１５２５、Ｔ１５２６、Ｔ１５２７、Ｔ１５２８、Ｔ１５２９、Ｔ１５３０、Ｔ１５３１、Ｔ１５３２、Ｔ１５３３、Ｔ１５３４、Ｔ１５３５、Ｔ１５３６、Ｔ１５３７、Ｔ１５３８、Ｔ１５３９、Ｔ１５４０、Ｔ１５４１、Ｔ１５４２、Ｔ１５４３、Ｔ１５４４、Ｔ１５４５、Ｔ１５４６、Ｔ１５４７、Ｔ１５４８、Ｔ１５４９、Ｔ１５５０、Ｔ１５５１は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１５０６、Ｔ１５０７及び／又はＴ１５１５、Ｔ１５１６及び／又はＴ１５２８、Ｔ１５２９及び／又はＴ１５３５、Ｔ１５３６及び／又はＴ１５４４、Ｔ１５４５は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１５５２、−ＮＴ１５５３Ｔ１５５４、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１５５５、−Ｃ（Ｏ）Ｏ−Ｔ１５５６、−Ｃ（Ｏ）ＮＨ−Ｔ１５５７、−Ｃ（Ｏ）ＮＴ１５５８Ｔ１５５９、−Ｏ−Ｔ１５６０、−Ｏ（−Ｔ１５６１−Ｏ）_rw−Ｈ（ｒｗ＝１、２、３、４、５）、−Ｏ（−Ｔ１５６２−Ｏ）_rw−Ｔ１５６３（ｒｗ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１５６４、−ＯＣ（Ｏ）−Ｏ−Ｔ１５６５、−ＯＣ（Ｏ）−ＮＨＴ１５６６、−Ｏ−Ｃ（Ｏ）−ＮＴ１５６７Ｔ１５６８、−ＯＰ（Ｏ）（ＯＴ１５６９）（ＯＴ１５７０）、−ＯＳｉ（Ｔ１５７１）（Ｔ１５７２）（Ｔ１５７３）、−ＯＳ（Ｏ₂）−Ｔ１５７４、−ＮＨＣ（Ｏ）−Ｔ１５５８、−ＮＴ１５７６Ｃ（Ｏ）−Ｔ１５７７、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１５７８、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１５７９、−ＮＨ−Ｃ（Ｏ）−ＮＴ１５８０Ｔ１５８１、−ＮＴ１５８２−Ｃ（Ｏ）−Ｏ−Ｔ１５８３、−ＮＴ１５８４−Ｃ（Ｏ）−ＮＨ−Ｔ１５８５、−ＮＴ１５８６−Ｃ（Ｏ）−ＮＴ１５８７Ｔ１５８８、−ＮＨＳ（Ｏ₂）−Ｔ１５８９、−ＮＴ１５９０Ｓ（Ｏ₂）−Ｔ１５９１、−Ｓ−Ｔ１５９２、−Ｓ（Ｏ）−Ｔ１５９３、−Ｓ（Ｏ₂）−Ｔ１５９４、−Ｓ（Ｏ₂）ＮＨ−Ｔ１５９５、−Ｓ（Ｏ₂）ＮＴ１５９６Ｔ１５９７、−Ｓ（Ｏ₂）Ｏ−Ｔ１５９８、−Ｐ（Ｏ）（ＯＴ１５９９）（ＯＴ１６００）、−Ｓｉ（Ｔ１６０１）（Ｔ１６０２）（Ｔ１６０３）"；
その際、Ｔ１５５２、Ｔ１５５３、Ｔ１５５４、Ｔ１５５５、Ｔ１５５６、Ｔ１５５７、Ｔ１５５８、Ｔ１５５９、Ｔ１５６０、Ｔ１５６１、Ｔ１５６２、Ｔ１５６３、Ｔ１５６４、Ｔ１５６５、Ｔ１５６６、Ｔ１５６７、Ｔ１５６８、Ｔ１５６９、Ｔ１５７０、Ｔ１５７１、Ｔ１５７２、Ｔ１５７３、Ｔ１５７４、Ｔ１５７５、Ｔ１５７６、Ｔ１５７７、Ｔ１５７８、Ｔ１５７９、Ｔ１５８０、Ｔ１５８１、Ｔ１５８２、Ｔ１５８３、Ｔ１５８４、Ｔ１５８５、Ｔ１５８６、Ｔ１５８７、Ｔ１５８８、Ｔ１５８９、Ｔ１５９０、Ｔ１５９１、Ｔ１５９２、Ｔ１５９３、Ｔ１５９４、Ｔ１５９５、Ｔ１５９６、Ｔ１５９７、Ｔ１５９８、Ｔ１５９９、Ｔ１６００、Ｔ１６０１、Ｔ１６０２、Ｔ１６０３は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１５５８、Ｔ１５５９及び／又はＴ１６５７、Ｔ１５６８及び／又はＴ１５８０、Ｔ１５８１及び／又はＴ１５８７、Ｔ１５８８及び／又はＴ１５９６、Ｔ１５９７は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１６０４、−ＮＴ１６０５Ｔ１６０６、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１６０７、−Ｃ（Ｏ）Ｏ−Ｔ１６０８、−Ｃ（Ｏ）ＮＨ−Ｔ１６０９、−Ｃ（Ｏ）ＮＴ１６１０Ｔ１６１１、−Ｏ−Ｔ１６１２、−Ｏ（−Ｔ１６１３−Ｏ）_rx−Ｈ（ｒｘ＝１、２、３、４、５）、−Ｏ（−Ｔ１６１４−Ｏ）_rx−Ｔ１６１５（ｒｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１６１６、−ＯＣ（Ｏ）−Ｏ−Ｔ１６１７、−ＯＣ（Ｏ）−ＮＨＴ１６１８、−Ｏ−Ｃ（Ｏ）−ＮＴ１６１９Ｔ１６２０、−ＯＰ（Ｏ）（ＯＴ１６２１）（ＯＴ１６２２）、−ＯＳｉ（Ｔ１６２３）（Ｔ１６２４）（Ｔ１６２５）、−ＯＳ（Ｏ₂）−Ｔ１６２６、−ＮＨＣ（Ｏ）−Ｔ１６２７、−ＮＴ１６２８Ｃ（Ｏ）−Ｔ１６２９、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１６３０、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１６３１、−ＮＨ−Ｃ（Ｏ）−ＮＴ１６３２Ｔ１６３３、−ＮＴ１６３４−Ｃ（Ｏ）−Ｏ−Ｔ１６３５、−ＮＴ１６３６−Ｃ（Ｏ）−ＮＨ−Ｔ１６３７、−ＮＴ１６３８−Ｃ（Ｏ）−ＮＴ１６３９Ｔ１６４０、−ＮＨＳ（Ｏ₂）−Ｔ１６４１、−ＮＴ１６４２Ｓ（Ｏ₂）−Ｔ１６４３、−Ｓ−Ｔ１６４４、−Ｓ（Ｏ）−Ｔ１６４５、−Ｓ（Ｏ₂）−Ｔ１６４６、−Ｓ（Ｏ₂）ＮＨ−Ｔ１６４７、−Ｓ（Ｏ₂）ＮＴ１６４８Ｔ１６４９、−Ｓ（Ｏ₂）Ｏ−Ｔ１６５０、−Ｐ（Ｏ）（ＯＴ１６５１）（ＯＴ１６５２）、−Ｓｉ（Ｔ１６５３）（Ｔ１６５４）（Ｔ１６５５）"；
その際、Ｔ１６０４、Ｔ１６０５、Ｔ１６０６、Ｔ１６０７、Ｔ１６０８、Ｔ１６０９、Ｔ１６１０、Ｔ１６１１、Ｔ１６１２、Ｔ１６１３、Ｔ１６１４、Ｔ１６１５、Ｔ１６１６、Ｔ１６１７、Ｔ１６１８、Ｔ１６１９、Ｔ１６２０、Ｔ１６２１、Ｔ１６２２、Ｔ１６２３、Ｔ１６２４、Ｔ１６２５、Ｔ１６２６、Ｔ１６２７、Ｔ１６２８、Ｔ１６２９、Ｔ１６３０、Ｔ１６３１、Ｔ１６３２、Ｔ１６３３、Ｔ１６３４、Ｔ１６３５、Ｔ１６３６、Ｔ１６３７、Ｔ１６３８、Ｔ１６３９、Ｔ１６４０、Ｔ１６４１、Ｔ１６４２、Ｔ１６４３、Ｔ１６４４、Ｔ１６４５、Ｔ１６４６、Ｔ１６４７、Ｔ１６４８、Ｔ１６４９、Ｔ１６５０、Ｔ１６５１、Ｔ１６５２、Ｔ１６５３、Ｔ１６５４、Ｔ１６５５は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１６１０、Ｔ１６１１及び／又はＴ１６１９、Ｔ１６２０及び／又はＴ１６３２、Ｔ１６３３及び／又はＴ１６３９、Ｔ１６４０及び／又はＴ１６４８、Ｔ１６４９は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、選択的に、Ｔ１４４６、Ｔ１４４７は、一緒になって、"ヘテロシクリル"を形成することもできる；
（３）"−Ｃ（Ｙ８）ＮＺ４３Ｚ４４、−Ｃ（＝ＮＺ４５）−Ｚ４６、−Ｃ（Ｙ９）ＮＺ４７−Ｙ１０−Ｚ４８"；
その際、Ｙ８、Ｙ９、Ｙ１０は、互いに無関係に、"Ｏ、Ｓ、＝ＮＨ、＝ＮＺ４９"からなる群から選択される；
その際、基Ｚ４３、Ｚ４４、Ｚ４５、Ｚ４６、Ｚ４７、Ｚ４８、Ｚ４９は、互いに無関係に、以下のものからなる群から選択される：
（Ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−アルキル、−Ｃ（Ｏ）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｃ（Ｏ）−シクロアルキル、−Ｃ（Ｏ）−シクロアルキルアルキル、−Ｃ（Ｏ）−アリール、−Ｃ（Ｏ）−アリールアルキル、−Ｃ（Ｏ）−ヘテロアリール、−Ｃ（Ｏ）−ヘテロアリールアルキル、−Ｃ（Ｏ）−ヘテロシクリル、−Ｃ（Ｏ）−ヘテロシクリルアルキル、−Ｓ（Ｏ₂）−アルキル、−Ｓ（Ｏ₂）−Ｃ₉〜Ｃ₃₀−アルキル、−Ｓ（Ｏ₂）−シクロアルキル、−Ｓ（Ｏ₂）−シクロアルキルアルキル、−Ｓ（Ｏ₂）−アリール、−Ｓ（Ｏ₂）−アリールアルキル、−Ｓ（Ｏ₂）−ヘテロアリール、−Ｓ（Ｏ₂）−ヘテロアリールアルキル、−Ｓ（Ｏ₂）−ヘテロシクリル、−Ｓ（Ｏ₂）−ヘテロシクリルアルキル"；
その際、場合により、置換基群（Ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてもよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１６５６、−ＮＴ１６５７Ｔ１６５８、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１６５９、−Ｃ（Ｏ）Ｏ−Ｔ１６６０、−Ｃ（Ｏ）ＮＨ−Ｔ１６６１、−Ｃ（Ｏ）ＮＴ１６６２Ｔ１６６３、−Ｏ−Ｔ１６６４、−Ｏ（−Ｔ１６６５−Ｏ）_ry−Ｈ（ｒｙ＝１、２、３、４、５）、−Ｏ（−Ｔ１６６６−Ｏ）_ry−Ｔ１６６７（ｒｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１６６８、−ＯＣ（Ｏ）−Ｏ−Ｔ１６６９、−ＯＣ（Ｏ）−ＮＨＴ１６７０、−Ｏ−Ｃ（Ｏ）−ＮＴ１６７１Ｔ１６７２、−ＯＰ（Ｏ）（ＯＴ１６７３）（ＯＴ１６７４）、−ＯＳｉ（Ｔ１６７５）（Ｔ１６７６）（Ｔ１６７７）、−ＯＳ（Ｏ₂）−Ｔ１６７８、−ＮＨＣ（Ｏ）−Ｔ１６７９、−ＮＴ１６８０Ｃ（Ｏ）−Ｔ１６８１、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１６８２、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１６８３、−ＮＨ−Ｃ（Ｏ）−ＮＴ１６８４Ｔ１６８５、−ＮＴ１６８６−Ｃ（Ｏ）−Ｏ−Ｔ１６８７、−ＮＴ１６８８−Ｃ（Ｏ）−ＮＨ−Ｔ１６８９、−ＮＴ１６９０−Ｃ（Ｏ）−ＮＴ１６９１Ｔ１６９２、−ＮＨＳ（Ｏ₂）−Ｔ１６９３、−ＮＴ１６９４Ｓ（Ｏ₂）−Ｔ１６９５、−Ｓ−Ｔ１６９６、−Ｓ（Ｏ）−Ｔ１６９７、−Ｓ（Ｏ₂）−Ｔ１６９８、−Ｓ（Ｏ₂）ＮＨ−Ｔ１６９９、−Ｓ（Ｏ₂）ＮＴ１７００Ｔ１７０１、−Ｓ（Ｏ₂）Ｏ−Ｔ１７０２、−Ｐ（Ｏ）（ＯＴ１７０３）（ＯＴ１７０４）、−Ｓｉ（Ｔ１７０５）（Ｔ１７０６）（Ｔ１７０７）"；
その際、Ｔ１６５６、Ｔ１６５７、Ｔ１６５８、Ｔ１６５９、Ｔ１６６０、Ｔ１６６１、Ｔ１６６２、Ｔ１６６３、Ｔ１６６４、Ｔ１６６５、Ｔ１６６６、Ｔ１６６７、Ｔ１６６８、Ｔ１６６９、Ｔ１６７０、Ｔ１６７１、Ｔ１６７２、Ｔ１６７３、Ｔ１６７４、Ｔ１６７５、Ｔ１６７６、Ｔ１６７７、Ｔ１６７８、Ｔ１６７９、Ｔ１６８０、Ｔ１６８１、Ｔ１６８２、Ｔ１６８３、Ｔ１６８４、Ｔ１６８５、Ｔ１６８６、Ｔ１６８７、Ｔ１６８８、Ｔ１６８９、Ｔ１６９０、Ｔ１６９１、Ｔ１６９２、Ｔ１６９３、Ｔ１６９４、Ｔ１６９５、Ｔ１６９６、Ｔ１６９７、Ｔ１６９８、Ｔ１６９９、Ｔ１７００、Ｔ１７０１、Ｔ１７０２、Ｔ１７０３、Ｔ１７０４、Ｔ１７０５、Ｔ１７０６、Ｔ１７０７は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１６６２、Ｔ１６６３及び／又はＴ１６７１、Ｔ１６７２及び／又はＴ１６８４、Ｔ１６８５及び／又はＴ１６９１、Ｔ１６９２及び／又はＴ１７００、Ｔ１７０１は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１７０８、−ＮＴ１７０９Ｔ１７１０、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１７１１、−Ｃ（Ｏ）Ｏ−Ｔ１７１２、−Ｃ（Ｏ）ＮＨ−Ｔ１７１３、−Ｃ（Ｏ）ＮＴ１７１４Ｔ１７１５、−Ｏ−Ｔ１７１６、−Ｏ（−Ｔ１７１７−Ｏ）_rz−Ｈ（ｒｚ＝１、２、３、４、５）、−Ｏ（−Ｔ１７１８−Ｏ）_rz−Ｔ１７１９（ｒｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１７２０、−ＯＣ（Ｏ）−Ｏ−Ｔ１７２１、−ＯＣ（Ｏ）−ＮＨＴ１７２２、−Ｏ−Ｃ（Ｏ）−ＮＴ１７２３Ｔ１７２４、−ＯＰ（Ｏ）（ＯＴ１７２５）（ＯＴ１７２６）、−ＯＳｉ（Ｔ１７２７）（Ｔ１７２８）（Ｔ１７２９）、−ＯＳ（Ｏ₂）−Ｔ１７３０、−ＮＨＣ（Ｏ）−Ｔ１７３１、−ＮＴ１７３２Ｃ（Ｏ）−Ｔ１７３３、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１７３４、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１７３５、−ＮＨ−Ｃ（Ｏ）−ＮＴ１７３６Ｔ１７３７、−ＮＴ１７３８−Ｃ（Ｏ）−Ｏ−Ｔ１７３９、−ＮＴ１７４０−Ｃ（Ｏ）−ＮＨ−Ｔ１７４１、−ＮＴ１７４２−Ｃ（Ｏ）−ＮＴ１７４３Ｔ１７４４、−ＮＨＳ（Ｏ₂）−Ｔ１７４５、−ＮＴ１７４６Ｓ（Ｏ₂）−Ｔ１７４７、−Ｓ−Ｔ１７４８、−Ｓ（Ｏ）−Ｔ１７４９、−Ｓ（Ｏ₂）−Ｔ１７５０、−Ｓ（Ｏ₂）ＮＨ−Ｔ１７５１、−Ｓ（Ｏ₂）ＮＴ１７５２Ｔ１７５３、−Ｓ（Ｏ₂）Ｏ−Ｔ１７５４、−Ｐ（Ｏ）（ＯＴ１７５５）（ＯＴ１７５６）、−Ｓｉ（Ｔ１７５７）（Ｔ１７５８）（Ｔ１７５９）"；
その際、Ｔ１７０８、Ｔ１７０９、Ｔ１７１０、Ｔ１７１１、Ｔ１７１２、Ｔ１７１３、Ｔ１７１４、Ｔ１７１５、Ｔ１７１６、Ｔ１７１７、Ｔ１７１８、Ｔ１７１９、Ｔ１７２０、Ｔ１７２１、Ｔ１７２２、Ｔ１７２３、Ｔ１７２４、Ｔ１７２５、Ｔ１７２６、Ｔ１７２７、Ｔ１７２８、Ｔ１７２９、Ｔ１７３０、Ｔ１７３１、Ｔ１７３２、Ｔ１７３３、Ｔ１７３４、Ｔ１７３５、Ｔ１７３６、Ｔ１７３７、Ｔ１７３８、Ｔ１７３９、Ｔ１７４０、Ｔ１７４１、Ｔ１７４２、Ｔ１７４３、Ｔ１７４４、Ｔ１７４５、Ｔ１７４６、Ｔ１７４７、Ｔ１７４８、Ｔ１７４９、Ｔ１７５０、Ｔ１７５１、Ｔ１７５２、Ｔ１７５３、Ｔ１７５４、Ｔ１７５５、Ｔ１７５６、Ｔ１７５７、Ｔ１７５８、Ｔ１７５９は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１７１４、Ｔ１７１５及び／又はＴ１７２３、Ｔ１７２４及び／又はＴ１７３６、Ｔ１７３７及び／又はＴ１７４３、Ｔ１７４４及び／又はＴ１７５２、Ｔ１７５３は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＴ１７６０、−ＮＴ１７６１Ｔ１７６２、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｔ１７６３、−Ｃ（Ｏ）Ｏ−Ｔ１７６４、−Ｃ（Ｏ）ＮＨ−Ｔ１７６５、−Ｃ（Ｏ）ＮＴ１７６６Ｔ１７６７、−Ｏ−Ｔ１７６８、−Ｏ（−Ｔ１７６９−Ｏ）_ra−Ｈ（ｒａ＝１、２、３、４、５）、−Ｏ（−Ｔ１７７０−Ｏ）_ra−Ｔ１７７１（ｒａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｔ１７７２、−ＯＣ（Ｏ）−Ｏ−Ｔ１７７３、−ＯＣ（Ｏ）−ＮＨＴ１７７４、−Ｏ−Ｃ（Ｏ）−ＮＴ１７７５Ｔ１７７６、−ＯＰ（Ｏ）（ＯＴ１７７７）（ＯＴ１７７８）、−ＯＳｉ（Ｔ１７７９）（Ｔ１７８０）（Ｔ１７８１）、−ＯＳ（Ｏ₂）−Ｔ１７８２、−ＮＨＣ（Ｏ）−Ｔ１７８３、−ＮＴ１７８４Ｃ（Ｏ）−Ｔ１７８５、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｔ１７８６、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｔ１７８７、−ＮＨ−Ｃ（Ｏ）−ＮＴ１７８８Ｔ１７８９、−ＮＴ１７９０−Ｃ（Ｏ）−Ｏ−Ｔ１７９１、−ＮＴ１７９２−Ｃ（Ｏ）−ＮＨ−Ｔ１７９３、−ＮＴ１７９４−Ｃ（Ｏ）−ＮＴ１７９５Ｔ１７９６、−ＮＨＳ（Ｏ₂）−Ｔ１７９７、−ＮＴ１７９８Ｓ（Ｏ₂）−Ｔ１７９９、−Ｓ−Ｔ１８００、−Ｓ（Ｏ）−Ｔ１８０１、−Ｓ（Ｏ₂）−Ｔ１８０２、−Ｓ（Ｏ₂）ＮＨ−Ｔ１８０３、−Ｓ（Ｏ₂）ＮＴ１８０４Ｔ１８０５、−Ｓ（Ｏ₂）Ｏ−Ｔ１８０６、−Ｐ（Ｏ）（ＯＴ１８０７）（ＯＴ１８０８）、−Ｓｉ（Ｔ１８０９）（Ｔ１８１０）（Ｔ１８１１）"；
その際、Ｔ１７６０、Ｔ１７６１、Ｔ１７６２、Ｔ１７６３、Ｔ１７６４、Ｔ１７６５、Ｔ１７６６、Ｔ１７６７、Ｔ１７６８、Ｔ１７６９、Ｔ１７７０、Ｔ１７７１、Ｔ１７７２、Ｔ１７７３、Ｔ１７７４、Ｔ１７７５、Ｔ１７７６、Ｔ１７７７、Ｔ１７７８、Ｔ１７７９、Ｔ１７８０、Ｔ１７８１、Ｔ１７８２、Ｔ１７８３、Ｔ１７８４、Ｔ１７８５、Ｔ１７８６、Ｔ１７８７、Ｔ１７８８、Ｔ１７８９、Ｔ１７９０、Ｔ１７９１、Ｔ１７９２、Ｔ１７９３、Ｔ１７９４、Ｔ１７９５、Ｔ１７９６、Ｔ１７９７、Ｔ１７９８、Ｔ１７９９、Ｔ１８００、Ｔ１８０１、Ｔ１８０２、Ｔ１８０３、Ｔ１８０４、Ｔ１８０５、Ｔ１８０６、Ｔ１８０７、Ｔ１８０８、Ｔ１８０９、Ｔ１８１０、Ｔ１８１１は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＴ１７６６、Ｔ１７６７及び／又はＴ１７７５、Ｔ１７７６及び／又はＴ１７８８、Ｔ１７８９及び／又はＴ１７９５、Ｔ１７９６及び／又はＴ１８０４、Ｔ１８０５は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ３、Ｚ４は、互いに無関係に、以下のものからなる群から選択される：
（ｅ）水素；
（ｆ）ハロゲン、Ｆ、Ｃｌ、Ｂｒ、Ｉ；
（ｇ）非置換もしくは置換されたアルキルもしくはＣ₉〜Ｃ₃₀−アルキル、
その際、場合により、前記のアルキル基もしくはＣ₉〜Ｃ₃₀−アルキル基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ４５７、−ＮＢ４５８Ｂ４５９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ４６０、−Ｃ（Ｏ）Ｏ−Ｂ４６１、−Ｃ（Ｏ）ＮＨ−Ｂ４６２、−Ｃ（Ｏ）ＮＢ４６３Ｂ４６４、−Ｏ−Ｂ４６５、−Ｏ（−Ｂ４６６−Ｏ）_x−Ｈ（ｘ＝１、２、３、４、５）、−Ｏ（−Ｂ４６７−Ｏ）_x−Ｂ４６８（ｘ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ４６９、−ＯＣ（Ｏ）−Ｏ−Ｂ４７０、−ＯＣ（Ｏ）−ＮＨＢ４７１、−Ｏ−Ｃ（Ｏ）−ＮＢ４７２Ｂ４７３、−ＯＰ（Ｏ）（ＯＢ４７４）（ＯＢ４７５）、−ＯＳｉ（Ｂ４７６）（Ｂ４７７）（Ｂ４７８）、−ＯＳ（Ｏ₂）−Ｂ４７９、−ＮＨＣ（Ｏ）−Ｂ４８０、−ＮＢ４８１Ｃ（Ｏ）−Ｂ４８２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ４８３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ４８４、−ＮＨ−Ｃ（Ｏ）−ＮＢ４８５Ｂ４８６、−ＮＢ４８７−Ｃ（Ｏ）−Ｏ−Ｂ４８８、−ＮＢ４８９−Ｃ（Ｏ）−ＮＨ−Ｂ４９０、−ＮＢ４９１−Ｃ（Ｏ）−ＮＢ４９２Ｂ４９３、−ＮＨＳ（Ｏ₂）−Ｂ４９４、−ＮＢ４９５Ｓ（Ｏ₂）−Ｂ４９６、−Ｓ−Ｂ４９７、−Ｓ（Ｏ）−Ｂ４９８、−Ｓ（Ｏ₂）−Ｂ４９９、−Ｓ（Ｏ₂）ＮＨ−Ｂ５００、−Ｓ（Ｏ₂）ＮＢ５０１Ｂ５０２、−Ｓ（Ｏ₂）Ｏ−Ｂ５０３、−Ｐ（Ｏ）（ＯＢ５０４）（ＯＢ５０５）、−Ｓｉ（Ｂ５０６）（Ｂ５０７）（Ｂ５０８）"；
その際、Ｂ４５７、Ｂ４５８、Ｂ４５９、Ｂ４６０、Ｂ４６１、Ｂ４６２、Ｂ４６３、Ｂ４６４、Ｂ４６５、Ｂ４６６、Ｂ４６７、Ｂ４６８、Ｂ４６９、Ｂ４７０、Ｂ４７１、Ｂ４７２、Ｂ４７３、Ｂ４７４、Ｂ４７５、Ｂ４７６、Ｂ４７７、Ｂ４７８、Ｂ４７９、Ｂ４８０、Ｂ４８１、Ｂ４８２、Ｂ４８３、Ｂ４８４、Ｂ４８５、Ｂ４８６、Ｂ４８７、Ｂ４８８、Ｂ４８９、Ｂ４９０、Ｂ４９１、Ｂ４９２、Ｂ４９３、Ｂ４９４、Ｂ４９５、Ｂ４９６、Ｂ４９７、Ｂ４９８、Ｂ４９９、Ｂ５００、Ｂ５０１、Ｂ５０２、Ｂ５０３、Ｂ５０４、Ｂ５０５、Ｂ５０６、Ｂ５０７、Ｂ５０８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ４６３、Ｂ４６４及び／又はＢ４７２、Ｂ４７３及び／又はＢ４８５、Ｂ４８６及び／又はＢ４９２、Ｂ４９３及び／又はＢ５０１、Ｂ５０２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ５０９、−ＮＢ５１０Ｂ５１１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ５１２、−Ｃ（Ｏ）Ｏ−Ｂ５１３、−Ｃ（Ｏ）ＮＨ−Ｂ５１４、−Ｃ（Ｏ）ＮＢ５１５Ｂ５１６、−Ｏ−Ｂ５１７、−Ｏ（−Ｂ５１８−Ｏ）_y−Ｈ（ｙ＝１、２、３、４、５）、−Ｏ（−Ｂ５１９−Ｏ）_y−Ｂ５２０（ｙ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ５２１、−ＯＣ（Ｏ）−Ｏ−Ｂ５２２、−ＯＣ（Ｏ）−ＮＨＢ５２３、−Ｏ−Ｃ（Ｏ）−ＮＢ５２４Ｂ５２５、−ＯＰ（Ｏ）（ＯＢ５２６）（ＯＢ５２７）、−ＯＳｉ（Ｂ５２８）（Ｂ５２９）（Ｂ５３０）、−ＯＳ（Ｏ₂）−Ｂ５３１、−ＮＨＣ（Ｏ）−Ｂ５３２、−ＮＢ５３３Ｃ（Ｏ）−Ｂ５３４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ５３５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ５３６、−ＮＨ−Ｃ（Ｏ）−ＮＢ５３７Ｂ５３８、−ＮＢ５３９−Ｃ（Ｏ）−Ｏ−Ｂ５４０、−ＮＢ５４１−Ｃ（Ｏ）−ＮＨ−Ｂ５４２、−ＮＢ５４３−Ｃ（Ｏ）−ＮＢ５４４Ｂ５４５、−ＮＨＳ（Ｏ₂）−Ｂ５４６、−ＮＢ５４７Ｓ（Ｏ₂）−Ｂ５４８、−Ｓ−Ｂ５４９、−Ｓ（Ｏ）−Ｂ５５０、−Ｓ（Ｏ₂）−Ｂ５５１、−Ｓ（Ｏ₂）ＮＨ−Ｂ５５２、−Ｓ（Ｏ₂）ＮＢ５５３Ｂ５５４、−Ｓ（Ｏ₂）Ｏ−Ｂ５５５、−Ｐ（Ｏ）（ＯＢ５５６）（ＯＢ５５７）、−Ｓｉ（Ｂ５５８）（Ｂ５５９）（Ｂ５６０）"；
その際、Ｂ５０９、Ｂ５１０、Ｂ５１１、Ｂ５１２、Ｂ５１３、Ｂ５１４、Ｂ５１５、Ｂ５１６、Ｂ５１７、Ｂ５１８、Ｂ５１９、Ｂ５２０、Ｂ５２１、Ｂ５２２、Ｂ５２３、Ｂ５２４、Ｂ５２５、Ｂ５２６、Ｂ５２７、Ｂ５２８、Ｂ５２９、Ｂ５３０、Ｂ５３１、Ｂ５３２、Ｂ５３３、Ｂ５３４、Ｂ５３５、Ｂ５３６、Ｂ５３７、Ｂ５３８、Ｂ５３９、Ｂ５４０、Ｂ５４１、Ｂ５４２、Ｂ５４３、Ｂ５４４、Ｂ５４５、Ｂ５４６、Ｂ５４７、Ｂ５４８、Ｂ５４９、Ｂ５５０、Ｂ５５１、Ｂ５５２、Ｂ５５３、Ｂ５５４、Ｂ５５５、Ｂ５５６、Ｂ５５７、Ｂ５５８、Ｂ５５９、Ｂ５６０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ５１５、Ｂ５１６及び／又はＢ５２４、Ｂ５２５及び／又はＢ５３７、Ｂ５３８及び／又はＢ５４４、Ｂ５４５及び／又はＢ５５３、Ｂ５５４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ５６１、−ＮＢ５６２Ｂ５６３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ５６４、−Ｃ（Ｏ）Ｏ−Ｂ５６５、−Ｃ（Ｏ）ＮＨ−Ｂ５６６、−Ｃ（Ｏ）ＮＢ５６７Ｂ５６８、−Ｏ−Ｂ５６９、−Ｏ（−Ｂ５７０−Ｏ）_z−Ｈ（ｚ＝１、２、３、４、５）、−Ｏ（−Ｂ５７１−Ｏ）_z−Ｂ５７２（ｚ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ５７３、−ＯＣ（Ｏ）−Ｏ−Ｂ５７４、−ＯＣ（Ｏ）−ＮＨＢ５７５、−Ｏ−Ｃ（Ｏ）−ＮＢ５７６Ｂ５７７、−ＯＰ（Ｏ）（ＯＢ５７８）（ＯＢ５７９）、−ＯＳｉ（Ｂ５８０）（Ｂ５８１）（Ｂ５８２）、−ＯＳ（Ｏ₂）−Ｂ５８３、−ＮＨＣ（Ｏ）−Ｂ５８４、−ＮＢ５８５Ｃ（Ｏ）−Ｂ５８６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ５８７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ５８８、−ＮＨ−Ｃ（Ｏ）−ＮＢ５８９Ｂ５９０、−ＮＢ５９１−Ｃ（Ｏ）−Ｏ−Ｂ５９２、−ＮＢ５９３−Ｃ（Ｏ）−ＮＨ−Ｂ５９４、−ＮＢ５９５−Ｃ（Ｏ）−ＮＢ５９６Ｂ５９７、−ＮＨＳ（Ｏ₂）−Ｂ５９８、−ＮＢ５９９Ｓ（Ｏ₂）−Ｂ６００、−Ｓ−Ｂ６０１、−Ｓ（Ｏ）−Ｂ６０２、−Ｓ（Ｏ₂）−Ｂ６０３、−Ｓ（Ｏ₂）ＮＨ−Ｂ６０４、−Ｓ（Ｏ₂）ＮＢ６０５Ｂ６０６、−Ｓ（Ｏ₂）Ｏ−Ｂ６０７、−Ｐ（Ｏ）（ＯＢ６０８）（ＯＢ６０９）、−Ｓｉ（Ｂ６１０）（Ｂ６１１）（Ｂ６１２）"；
その際、Ｂ５６１、Ｂ５６２、Ｂ５６３、Ｂ５６４、Ｂ５６５、Ｂ５６６、Ｂ５６７、Ｂ５６８、Ｂ５６９、Ｂ５７０、Ｂ５７１、Ｂ５７２、Ｂ５７３、Ｂ５７４、Ｂ５７５、Ｂ５７６、Ｂ５７７、Ｂ５７８、Ｂ５７９、Ｂ５８０、Ｂ５８１、Ｂ５８２、Ｂ５８３、Ｂ５８４、Ｂ５８５、Ｂ５８６、Ｂ５８７、Ｂ５８８、Ｂ５８９、Ｂ５９０、Ｂ５９１、Ｂ５９２、Ｂ５９３、Ｂ５９４、Ｂ５９５、Ｂ５９６、Ｂ５９７、Ｂ５９８、Ｂ５９９、Ｂ６００、Ｂ６０１、Ｂ６０２、Ｂ６０３、Ｂ６０４、Ｂ６０５、Ｂ６０６、Ｂ６０７、Ｂ６０８、Ｂ６０９、Ｂ６１０、Ｂ６１１、Ｂ６１２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ５６７、Ｂ５６８及び／又はＢ５７６、Ｂ５７７及び／又はＢ５８９、Ｂ５９０及び／又はＢ５９６、Ｂ５９７及び／又はＢ６０５、Ｂ６０６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｈ）非置換もしくは置換されたアリール、
その際、場合により、前記のアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ６１３、−ＮＢ６１４Ｂ６１５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ６１６、−Ｃ（Ｏ）Ｏ−Ｂ６１７、−Ｃ（Ｏ）ＮＨ−Ｂ６１８、−Ｃ（Ｏ）ＮＢ６１９Ｂ６２０、−Ｏ−Ｂ６２１、−Ｏ（−Ｂ６２２−Ｏ）_a−Ｈ（ａ＝１、２、３、４、５）、−Ｏ（−Ｂ６２３−Ｏ）_a−Ｂ６２４（ａ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ６２５、−ＯＣ（Ｏ）−Ｏ−Ｂ６２６、−ＯＣ（Ｏ）−ＮＨＢ６２７、−Ｏ−Ｃ（Ｏ）−ＮＢ６２８Ｂ６２９、−ＯＰ（Ｏ）（ＯＢ６３０）（ＯＢ６３１）、−ＯＳｉ（Ｂ６３２）（Ｂ６３３）（Ｂ６３４）、−ＯＳ（Ｏ₂）−Ｂ６３５、−ＮＨＣ（Ｏ）−Ｂ６３６、−ＮＢ６３７Ｃ（Ｏ）−Ｂ６３８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ６３９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ６４０、−ＮＨ−Ｃ（Ｏ）−ＮＢ６４１Ｂ６４２、−ＮＢ６４３−Ｃ（Ｏ）−Ｏ−Ｂ６４４、−ＮＢ６４５−Ｃ（Ｏ）−ＮＨ−Ｂ６４６、−ＮＢ６４７−Ｃ（Ｏ）−ＮＢ６４８Ｂ６４９、−ＮＨＳ（Ｏ₂）−Ｂ６５０、−ＮＢ６５１Ｓ（Ｏ₂）−Ｂ６５２、−Ｓ−Ｂ６５３、−Ｓ（Ｏ）−Ｂ６５４、−Ｓ（Ｏ₂）−Ｂ６５５、−Ｓ（Ｏ₂）ＮＨ−Ｂ６５６、−Ｓ（Ｏ₂）ＮＢ６５７Ｂ６５８、−Ｓ（Ｏ₂）Ｏ−Ｂ６５９、−Ｐ（Ｏ）（ＯＢ６６０）（ＯＢ６６１）、−Ｓｉ（Ｂ６６２）（Ｂ６６３）（Ｂ６６４）"；
その際、Ｂ６１３、Ｂ６１４、Ｂ６１５、Ｂ６１６、Ｂ６１７、Ｂ６１８、Ｂ６１９、Ｂ６２０、Ｂ６２１、Ｂ６２２、Ｂ６２３、Ｂ６２４、Ｂ６２５、Ｂ６２６、Ｂ６２７、Ｂ６２８、Ｂ６２９、Ｂ６３０、Ｂ６３１、Ｂ６３２、Ｂ６３３、Ｂ６３４、Ｂ６３５、Ｂ６３６、Ｂ６３７、Ｂ６３８、Ｂ６３９、Ｂ６４０、Ｂ６４１、Ｂ６４２、Ｂ６４３、Ｂ６４４、Ｂ６４５、Ｂ６４６、Ｂ６４７、Ｂ６４８、Ｂ６４９、Ｂ６５０、Ｂ６５１、Ｂ６５２、Ｂ６５３、Ｂ６５４、Ｂ６５５、Ｂ６５６、Ｂ６５７、Ｂ６５８、Ｂ６５９、Ｂ６６０、Ｂ６６１、Ｂ６６２、Ｂ６６３、Ｂ６６４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ６１９、Ｂ６２０及び／又はＢ６２８、Ｂ６２９及び／又はＢ６４１、Ｂ６４２及び／又はＢ６４８、Ｂ６４９及び／又はＢ６５７、Ｂ６５８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ６６５、−ＮＢ６６６Ｂ６６７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ６６８、−Ｃ（Ｏ）Ｏ−Ｂ６６９、−Ｃ（Ｏ）ＮＨ−Ｂ６７０、−Ｃ（Ｏ）ＮＢ６７１Ｂ６７２、−Ｏ−Ｂ６７３、−Ｏ（−Ｂ６７４−Ｏ）_b−Ｈ（ｂ＝１、２、３、４、５）、−Ｏ（−Ｂ６７５−Ｏ）_b−Ｂ６７６（ｂ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ６７７、−ＯＣ（Ｏ）−Ｏ−Ｂ６７８、−ＯＣ（Ｏ）−ＮＨＢ６７９、−Ｏ−Ｃ（Ｏ）−ＮＢ６８０Ｂ６８１、−ＯＰ（Ｏ）（ＯＢ６８２）（ＯＢ６８３）、−ＯＳｉ（Ｂ６８４）（Ｂ６８５）（Ｂ６８６）、−ＯＳ（Ｏ₂）−Ｂ６８７、−ＮＨＣ（Ｏ）−Ｂ６８８、−ＮＢ６８９Ｃ（Ｏ）−Ｂ６９０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ６９１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ６９２、−ＮＨ−Ｃ（Ｏ）−ＮＢ６９３Ｂ６９４、−ＮＢ６９５−Ｃ（Ｏ）−Ｏ−Ｂ６９６、−ＮＢ６９７−Ｃ（Ｏ）−ＮＨ−Ｂ６９８、−ＮＢ６９９−Ｃ（Ｏ）−ＮＢ７００Ｂ７０１、−ＮＨＳ（Ｏ₂）−Ｂ７０２、−ＮＢ７０３Ｓ（Ｏ₂）−Ｂ７０４、−Ｓ−Ｂ７０５、−Ｓ（Ｏ）−Ｂ７０６、−Ｓ（Ｏ₂）−Ｂ７０７、−Ｓ（Ｏ₂）ＮＨ−Ｂ７０８、−Ｓ（Ｏ₂）ＮＢ７０９Ｂ７１０、−Ｓ（Ｏ₂）Ｏ−Ｂ７１１、−Ｐ（Ｏ）（ＯＢ７１２）（ＯＢ７１３）、−Ｓｉ（Ｂ７１４）（Ｂ７１５）（Ｂ７１６）"；
その際、Ｂ６６５、Ｂ６６６、Ｂ６６７、Ｂ６６８、Ｂ６６９、Ｂ６７０、Ｂ６７１、Ｂ６７２、Ｂ６７３、Ｂ６７４、Ｂ６７５、Ｂ６７６、Ｂ６７７、Ｂ６７８、Ｂ６７９、Ｂ６８０、Ｂ６８１、Ｂ６８２、Ｂ６８３、Ｂ６８４、Ｂ６８５、Ｂ６８６、Ｂ６８７、Ｂ６８８、Ｂ６８９、Ｂ６９０、Ｂ６９１、Ｂ６９２、Ｂ６９３、Ｂ６９４、Ｂ６９５、Ｂ６９６、Ｂ６９７、Ｂ６９８、Ｂ６９９、Ｂ７００、Ｂ７０１、Ｂ７０２、Ｂ７０３、Ｂ７０４、Ｂ７０５、Ｂ７０６、Ｂ７０７、Ｂ７０８、Ｂ７０９、Ｂ７１０、Ｂ７１１、Ｂ７１２、Ｂ７１３、Ｂ７１４、Ｂ７１５、Ｂ７１６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ６７１、Ｂ６７２及び／又はＢ６８０、Ｂ６８１及び／又はＢ６９３、Ｂ６９４及び／又はＢ７００、Ｂ７０１及び／又はＢ７０９、Ｂ７１０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ７１７、−ＮＢ７１８Ｂ７１９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ７２０、−Ｃ（Ｏ）Ｏ−Ｂ７２１、−Ｃ（Ｏ）ＮＨ−Ｂ７２２、−Ｃ（Ｏ）ＮＢ７２３Ｂ７２４、−Ｏ−Ｂ７２５、−Ｏ（−Ｂ７２６−Ｏ）_c−Ｈ（ｃ＝１、２、３、４、５）、−Ｏ（−Ｂ７２７−Ｏ）_c−Ｂ７２８（ｃ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ７２９、−ＯＣ（Ｏ）−Ｏ−Ｂ７３０、−ＯＣ（Ｏ）−ＮＨＢ７３１、−Ｏ−Ｃ（Ｏ）−ＮＢ７３２Ｂ７３３、−ＯＰ（Ｏ）（ＯＢ７３４）（ＯＢ７３５）、−ＯＳｉ（Ｂ７３６）（Ｂ７３７）（Ｂ７３８）、−ＯＳ（Ｏ₂）−Ｂ７３９、−ＮＨＣ（Ｏ）−Ｂ７４０、−ＮＢ７４１Ｃ（Ｏ）−Ｂ７４２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ７４３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ７４４、−ＮＨ−Ｃ（Ｏ）−ＮＢ７４５Ｂ７４６、−ＮＢ７４７−Ｃ（Ｏ）−Ｏ−Ｂ７４８、−ＮＢ７４９−Ｃ（Ｏ）−ＮＨ−Ｂ７５０、−ＮＢ７５１−Ｃ（Ｏ）−ＮＢ７５２Ｂ７５３、−ＮＨＳ（Ｏ₂）−Ｂ７５４、−ＮＢ７５５Ｓ（Ｏ₂）−Ｂ７５６、−Ｓ−Ｂ７５７、−Ｓ（Ｏ）−Ｂ７５８、−Ｓ（Ｏ₂）−Ｂ７５９、−Ｓ（Ｏ₂）ＮＨ−Ｂ７６０、−Ｓ（Ｏ₂）ＮＢ７６１Ｂ７６２、−Ｓ（Ｏ₂）Ｏ−Ｂ７６３、−Ｐ（Ｏ）（ＯＢ７６４）（ＯＢ７６５）、−Ｓｉ（Ｂ７６６）（Ｂ７６７）（Ｂ７６８）"；
その際、Ｂ７１７、Ｂ７１８、Ｂ７１９、Ｂ７２０、Ｂ７２１、Ｂ７２２、Ｂ７２３、Ｂ７２４、Ｂ７２５、Ｂ７２６、Ｂ７２７、Ｂ７２８、Ｂ７２９、Ｂ７３０、Ｂ７３１、Ｂ７３２、Ｂ７３３、Ｂ７３４、Ｂ７３５、Ｂ７３６、Ｂ７３７、Ｂ７３８、Ｂ７３９、Ｂ７４０、Ｂ７４１、Ｂ７４２、Ｂ７４３、Ｂ７４４、Ｂ７４５、Ｂ７４６、Ｂ７４７、Ｂ７４８、Ｂ７４９、Ｂ７５０、Ｂ７５１、Ｂ７５２、Ｂ７５３、Ｂ７５４、Ｂ７５５、Ｂ７５６、Ｂ７５７、Ｂ７５８、Ｂ７５９、Ｂ７６０、Ｂ７６１、Ｂ７６２、Ｂ７６３、Ｂ７６４、Ｂ７６５、Ｂ７６６、Ｂ７６７、Ｂ７６８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ７２３、Ｂ７２４及び／又はＢ７３２、Ｂ７３３及び／又はＢ７４５、Ｂ７４６及び／又はＢ７５２、Ｂ７５３及び／又はＢ７６１、Ｂ７６２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｊ）非置換もしくは置換されたヘテロアリール、
その際、場合により、前記のヘテロアリール基は、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって置換されていてよい：
（ｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ７６９、−ＮＢ７７０Ｂ７７１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ７７２、−Ｃ（Ｏ）Ｏ−Ｂ７７３、−Ｃ（Ｏ）ＮＨ−Ｂ７７４、−Ｃ（Ｏ）ＮＢ７７５Ｂ７７６、−Ｏ−Ｂ７７７、−Ｏ（−Ｂ７７８−Ｏ）_d−Ｈ（ｄ＝１、２、３、４、５）、−Ｏ（−Ｂ７７９−Ｏ）_d−Ｂ７８０（ｄ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ７８１、−ＯＣ（Ｏ）−Ｏ−Ｂ７８２、−ＯＣ（Ｏ）−ＮＨＢ７８３、−Ｏ−Ｃ（Ｏ）−ＮＢ７８４Ｂ７８５、−ＯＰ（Ｏ）（ＯＢ７８６）（ＯＢ７８７）、−ＯＳｉ（Ｂ７８８）（Ｂ７８９）（Ｂ７９０）、−ＯＳ（Ｏ₂）−Ｂ７９１、−ＮＨＣ（Ｏ）−Ｂ７９２、−ＮＢ７９３Ｃ（Ｏ）−Ｂ７９４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ７９５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ７９６、−ＮＨ−Ｃ（Ｏ）−ＮＢ７９７Ｂ７９８、−ＮＢ７９９−Ｃ（Ｏ）−Ｏ−Ｂ８００、−ＮＢ８０１−Ｃ（Ｏ）−ＮＨ−Ｂ８０２、−ＮＢ８０３−Ｃ（Ｏ）−ＮＢ８０４Ｂ８０５、−ＮＨＳ（Ｏ₂）−Ｂ８０６、−ＮＢ８０７Ｓ（Ｏ₂）−Ｂ８０８、−Ｓ−Ｂ８０９、−Ｓ（Ｏ）−Ｂ８１０、−Ｓ（Ｏ₂）−Ｂ８１１、−Ｓ（Ｏ₂）ＮＨ−Ｂ８１２、−Ｓ（Ｏ₂）ＮＢ８１３Ｂ８１４、−Ｓ（Ｏ₂）Ｏ−Ｂ８１５、−Ｐ（Ｏ）（ＯＢ８１６）（ＯＢ８１７）、−Ｓｉ（Ｂ８１８）（Ｂ８１９）（Ｂ８２０）"；
その際、Ｂ７６９、Ｂ７７０、Ｂ７７１、Ｂ７７２、Ｂ７７３、Ｂ７７４、Ｂ７７５、Ｂ７７６、Ｂ７７７、Ｂ７７８、Ｂ７７９、Ｂ７８０、Ｂ７８１、Ｂ７８２、Ｂ７８３、Ｂ７８４、Ｂ７８５、Ｂ７８６、Ｂ７８７、Ｂ７８８、Ｂ７８９、Ｂ７９０、Ｂ７９１、Ｂ７９２、Ｂ７９３、Ｂ７９４、Ｂ７９５、Ｂ７９６、Ｂ７９７、Ｂ７９８、Ｂ７９９、Ｂ８００、Ｂ８０１、Ｂ８０２、Ｂ８０３、Ｂ８０４、Ｂ８０５、Ｂ８０６、Ｂ８０７、Ｂ８０８、Ｂ８０９、Ｂ８１０、Ｂ８１１、Ｂ８１２、Ｂ８１３、Ｂ８１４、Ｂ８１５、Ｂ８１６、Ｂ８１７、Ｂ８１８、Ｂ８１９、Ｂ８２０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ７７５、Ｂ７７６及び／又はＢ７８４、Ｂ７８５及び／又はＢ７９７、Ｂ７９８及び／又はＢ８０４、Ｂ８０５及び／又はＢ８１３、Ｂ８１４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ８２１、−ＮＢ８２２Ｂ８２３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ８２４、−Ｃ（Ｏ）Ｏ−Ｂ８２５、−Ｃ（Ｏ）ＮＨ−Ｂ８２６、−Ｃ（Ｏ）ＮＢ８２７Ｂ８２８、−Ｏ−Ｂ８２９、−Ｏ（−Ｂ８３０−Ｏ）_e−Ｈ（ｅ＝１、２、３、４、５）、−Ｏ（−Ｂ８３１−Ｏ）_e−Ｂ８３２（ｅ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ８３３、−ＯＣ（Ｏ）−Ｏ−Ｂ８３４、−ＯＣ（Ｏ）−ＮＨＢ８３５、−Ｏ−Ｃ（Ｏ）−ＮＢ８３６Ｂ８３７、−ＯＰ（Ｏ）（ＯＢ８３８）（ＯＢ８３９）、−ＯＳｉ（Ｂ８４０）（Ｂ８４１）（Ｂ８４２）、−ＯＳ（Ｏ₂）−Ｂ８４３、−ＮＨＣ（Ｏ）−Ｂ８４４、−ＮＢ８４５Ｃ（Ｏ）−Ｂ８４６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ８４７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ８４８、−ＮＨ−Ｃ（Ｏ）−ＮＢ８４９Ｂ８５０、−ＮＢ８５１−Ｃ（Ｏ）−Ｏ−Ｂ８５２、−ＮＢ８５３−Ｃ（Ｏ）−ＮＨ−Ｂ８５４、−ＮＢ８５５−Ｃ（Ｏ）−ＮＢ８５６Ｂ８５７、−ＮＨＳ（Ｏ₂）−Ｂ８５８、−ＮＢ８５９Ｓ（Ｏ₂）−Ｂ８６０、−Ｓ−Ｂ８６１、−Ｓ（Ｏ）−Ｂ８６２、−Ｓ（Ｏ₂）−Ｂ８６３、−Ｓ（Ｏ₂）ＮＨ−Ｂ８６４、−Ｓ（Ｏ₂）ＮＢ８６５Ｂ８６６、−Ｓ（Ｏ₂）Ｏ−Ｂ８６７、−Ｐ（Ｏ）（ＯＢ８６８）（ＯＢ８６９）、−Ｓｉ（Ｂ８７０）（Ｂ８７１）（Ｂ８７２）"；
その際、Ｂ８２１、Ｂ８２２、Ｂ８２３、Ｂ８２４、Ｂ８２５、Ｂ８２６、Ｂ８２７、Ｂ８２８、Ｂ８２９、Ｂ８３０、Ｂ８３１、Ｂ８３２、Ｂ８３３、Ｂ８３４、Ｂ８３５、Ｂ８３６、Ｂ８３７、Ｂ８３８、Ｂ８３９、Ｂ８４０、Ｂ８４１、Ｂ８４２、Ｂ８４３、Ｂ８４４、Ｂ８４５、Ｂ８４６、Ｂ８４７、Ｂ８４８、Ｂ８４９、Ｂ８５０、Ｂ８５１、Ｂ８５２、Ｂ８５３、Ｂ８５４、Ｂ８５５、Ｂ８５６、Ｂ８５７、Ｂ８５８、Ｂ８５９、Ｂ８６０、Ｂ８６１、Ｂ８６２、Ｂ８６３、Ｂ８６４、Ｂ８６５、Ｂ８６６、Ｂ８６７、Ｂ８６８、Ｂ８６９、Ｂ８７０、Ｂ８７１、Ｂ８７２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ８２７、Ｂ８２８及び／又はＢ８３６、Ｂ８３７及び／又はＢ８４９、Ｂ８５０及び／又はＢ８５６、Ｂ８５７及び／又はＢ８６５、Ｂ８６６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ８７３、−ＮＢ８７４Ｂ８７５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ８７６、−Ｃ（Ｏ）Ｏ−Ｂ８７７、−Ｃ（Ｏ）ＮＨ−Ｂ８７８、−Ｃ（Ｏ）ＮＢ８７９Ｂ８８０、−Ｏ−Ｂ８８１、−Ｏ（−Ｂ８８２−Ｏ）_f−Ｈ（ｆ＝１、２、３、４、５）、−Ｏ（−Ｂ８８３−Ｏ）_f−Ｂ８８４（ｆ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ８８５、−ＯＣ（Ｏ）−Ｏ−Ｂ８８６、−ＯＣ（Ｏ）−ＮＨＢ８８７、−Ｏ−Ｃ（Ｏ）−ＮＢ８８８Ｂ８８９、−ＯＰ（Ｏ）（ＯＢ８９０）（ＯＢ８９１）、−ＯＳｉ（Ｂ８９２）（Ｂ８９３）（Ｂ８９４）、−ＯＳ（Ｏ₂）−Ｂ８９５、−ＮＨＣ（Ｏ）−Ｂ８９６、−ＮＢ８９７Ｃ（Ｏ）−Ｂ８９８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ８９９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ９００、−ＮＨ−Ｃ（Ｏ）−ＮＢ９０１Ｂ９０２、−ＮＢ９０３−Ｃ（Ｏ）−Ｏ−Ｂ９０４、−ＮＢ９０５−Ｃ（Ｏ）−ＮＨ−Ｂ９０６、−ＮＢ９０７−Ｃ（Ｏ）−ＮＢ９０８Ｂ９０９、−ＮＨＳ（Ｏ₂）−Ｂ９１０、−ＮＢ９１１Ｓ（Ｏ₂）−Ｂ９１２、−Ｓ−Ｂ９１３、−Ｓ（Ｏ）−Ｂ９１４、−Ｓ（Ｏ₂）−Ｂ９１５、−Ｓ（Ｏ₂）ＮＨ−Ｂ９１６、−Ｓ（Ｏ₂）ＮＢ９１７Ｂ９１８、−Ｓ（Ｏ₂）Ｏ−Ｂ９１９、−Ｐ（Ｏ）（ＯＢ９２０）（ＯＢ９２１）、−Ｓｉ（Ｂ９２２）（Ｂ９２３）（Ｂ９２４）"；
その際、Ｂ８７３、Ｂ８７４、Ｂ８７５、Ｂ８７６、Ｂ８７７、Ｂ８７８、Ｂ８７９、Ｂ８８０、Ｂ８８１、Ｂ８８２、Ｂ８８３、Ｂ８８４、Ｂ８８５、Ｂ８８６、Ｂ８８７、Ｂ８８８、Ｂ８８９、Ｂ８９０、Ｂ８９１、Ｂ８９２、Ｂ８９３、Ｂ８９４、Ｂ８９５、Ｂ８９６、Ｂ８９７、Ｂ８９８、Ｂ８９９、Ｂ９００、Ｂ９０１、Ｂ９０２、Ｂ９０３、Ｂ９０４、Ｂ９０５、Ｂ９０６、Ｂ９０７、Ｂ９０８、Ｂ９０９、Ｂ９１０、Ｂ９１１、Ｂ９１２、Ｂ９１３、Ｂ９１４、Ｂ９１５、Ｂ９１６、Ｂ９１７、Ｂ９１８、Ｂ９１９、Ｂ９２０、Ｂ９２１、Ｂ９２２、Ｂ９２３、Ｂ９２４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ８７９、Ｂ８８０及び／又はＢ８８８、Ｂ８８９及び／又はＢ９０１、Ｂ９０２及び／又はＢ９０８、Ｂ９０９及び／又はＢ９１７、Ｂ９１８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｋ）ＯＺ６、
その際、Ｚ６は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ９２５、−ＮＢ９２６Ｂ９２７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ９２８、−Ｃ（Ｏ）Ｏ−Ｂ９２９、−Ｃ（Ｏ）ＮＨ−Ｂ９３０、−Ｃ（Ｏ）ＮＢ９３１Ｂ９３２、−Ｏ−Ｂ９３３、−Ｏ（−Ｂ９３４−Ｏ）_g−Ｈ（ｇ＝１、２、３、４、５）、−Ｏ（−Ｂ９３５−Ｏ）_g−Ｂ９３６（ｇ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ９３７、−ＯＣ（Ｏ）−Ｏ−Ｂ９３８、−ＯＣ（Ｏ）−ＮＨＢ９３９、−Ｏ−Ｃ（Ｏ）−ＮＢ９４０Ｂ９４１、−ＯＰ（Ｏ）（ＯＢ９４２）（ＯＢ９４３）、−ＯＳｉ（Ｂ９４４）（Ｂ９４５）（Ｂ９４６）、−ＯＳ（Ｏ₂）−Ｂ９４７、−ＮＨＣ（Ｏ）−Ｂ９４８、−ＮＢ９４９Ｃ（Ｏ）−Ｂ９５０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ９５１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ９５２、−ＮＨ−Ｃ（Ｏ）−ＮＢ９５３Ｂ９５４、−ＮＢ９５５−Ｃ（Ｏ）−Ｏ−Ｂ９５６、−ＮＢ９５７−Ｃ（Ｏ）−ＮＨ−Ｂ９５８、−ＮＢ９５９−Ｃ（Ｏ）−ＮＢ９６０Ｂ９６１、−ＮＨＳ（Ｏ₂）−Ｂ９６２、−ＮＢ９６３Ｓ（Ｏ₂）−Ｂ９６４、−Ｓ−Ｂ９６５、−Ｓ（Ｏ）−Ｂ９６６、−Ｓ（Ｏ₂）−Ｂ９６７、−Ｓ（Ｏ₂）ＮＨ−Ｂ９６８、−Ｓ（Ｏ₂）ＮＢ９６９Ｂ９７０、−Ｓ（Ｏ₂）Ｏ−Ｂ９７１、−Ｐ（Ｏ）（ＯＢ９７２）（ＯＢ９７３）、−Ｓｉ（Ｂ９７４）（Ｂ９７５）（Ｂ９７６）"；
その際、Ｂ９２５、Ｂ９２６、Ｂ９２７、Ｂ９２８、Ｂ９２９、Ｂ９３０、Ｂ９３１、Ｂ９３２、Ｂ９３３、Ｂ９３４、Ｂ９３５、Ｂ９３６、Ｂ９３７、Ｂ９３８、Ｂ９３９、Ｂ９４０、Ｂ９４１、Ｂ９４２、Ｂ９４３、Ｂ９４４、Ｂ９４５、Ｂ９４６、Ｂ９４７、Ｂ９４８、Ｂ９４９、Ｂ９５０、Ｂ９５１、Ｂ９５２、Ｂ９５３、Ｂ９５４、Ｂ９５５、Ｂ９５６、Ｂ９５７、Ｂ９５８、Ｂ９５９、Ｂ９６０、Ｂ９６１、Ｂ９６２、Ｂ９６３、Ｂ９６４、Ｂ９６５、Ｂ９６６、Ｂ９６７、Ｂ９６８、Ｂ９６９、Ｂ９７０、Ｂ９７１、Ｂ９７２、Ｂ９７３、Ｂ９７４、Ｂ９７５、Ｂ９７６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ９３１、Ｂ９３２及び／又はＢ９４０、Ｂ９４１及び／又はＢ９５３、Ｂ９５４及び／又はＢ９６０、Ｂ９６１及び／又はＢ９６９、Ｂ９７０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ９７７、−ＮＢ９７８Ｂ９７９、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ９８０、−Ｃ（Ｏ）Ｏ−Ｂ９８１、−Ｃ（Ｏ）ＮＨ−Ｂ９８２、−Ｃ（Ｏ）ＮＢ９８３Ｂ９８４、−Ｏ−Ｂ９８５、−Ｏ（−Ｂ９８６−Ｏ）_h−Ｈ（ｈ＝１、２、３、４、５）、−Ｏ（−Ｂ９８７−Ｏ）_h−Ｂ９８８（ｈ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ９８９、−ＯＣ（Ｏ）−Ｏ−Ｂ９９０、−ＯＣ（Ｏ）−ＮＨＢ９９１、−Ｏ−Ｃ（Ｏ）−ＮＢ９９２Ｂ９９３、−ＯＰ（Ｏ）（ＯＢ９９４）（ＯＢ９９５）、−ＯＳｉ（Ｂ９９６）（Ｂ９９７）（Ｂ９９８）、−ＯＳ（Ｏ₂）−Ｂ９９９、−ＮＨＣ（Ｏ）−Ｂ１０００、−ＮＢ１００１Ｃ（Ｏ）−Ｂ１００２、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ１００３、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ１００４、−ＮＨ−Ｃ（Ｏ）−ＮＢ１００５Ｂ１００６、−ＮＢ１００７−Ｃ（Ｏ）−Ｏ−Ｂ１００８、−ＮＢ１００９−Ｃ（Ｏ）−ＮＨ−Ｂ１０１０、−ＮＢ１０１１−Ｃ（Ｏ）−ＮＢ１０１２Ｂ１０１３、−ＮＨＳ（Ｏ₂）−Ｂ１０１４、−ＮＢ１０１５Ｓ（Ｏ₂）−Ｂ１０１６、−Ｓ−Ｂ１０１７、−Ｓ（Ｏ）−Ｂ１０１８、−Ｓ（Ｏ₂）−Ｂ１０１９、−Ｓ（Ｏ₂）ＮＨ−Ｂ１０２０、−Ｓ（Ｏ₂）ＮＢ１０２１Ｂ１０２２、−Ｓ（Ｏ₂）Ｏ−Ｂ１０２３、−Ｐ（Ｏ）（ＯＢ１０２４）（ＯＢ１０２５）、−Ｓｉ（Ｂ１０２６）（Ｂ１０２７）（Ｂ１０２８）"；
その際、Ｂ９７７、Ｂ９７８、Ｂ９７９、Ｂ９８０、Ｂ９８１、Ｂ９８２、Ｂ９８３、Ｂ９８４、Ｂ９８５、Ｂ９８６、Ｂ９８７、Ｂ９８８、Ｂ９８９、Ｂ９９０、Ｂ９９１、Ｂ９９２、Ｂ９９３、Ｂ９９４、Ｂ９９５、Ｂ９９６、Ｂ９９７、Ｂ９９８、Ｂ９９９、Ｂ１０００、Ｂ１００１、Ｂ１００２、Ｂ１００３、Ｂ１００４、Ｂ１００５、Ｂ１００６、Ｂ１００７、Ｂ１００８、Ｂ１００９、Ｂ１０１０、Ｂ１０１１、Ｂ１０１２、Ｂ１０１３、Ｂ１０１４、Ｂ１０１５、Ｂ１０１６、Ｂ１０１７、Ｂ１０１８、Ｂ１０１９、Ｂ１０２０、Ｂ１０２１、Ｂ１０２２、Ｂ１０２３、Ｂ１０２４、Ｂ１０２５、Ｂ１０２６、Ｂ１０２７、Ｂ１０２８は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ９８３、Ｂ９８４及び／又はＢ９９２、Ｂ９９３及び／又はＢ１００５、Ｂ１００６及び／又はＢ１０１２、Ｂ１０１３及び／又はＢ１０２１、Ｂ１０２２は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｌ）ＳＺ７、
その際、Ｚ７は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ１０２９、−ＮＢ１０３０Ｂ１０３１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ１０３２、−Ｃ（Ｏ）Ｏ−Ｂ１０３３、−Ｃ（Ｏ）ＮＨ−Ｂ１０３４、−Ｃ（Ｏ）ＮＢ１０３５Ｂ１０３６、−Ｏ−Ｂ１０３７、−Ｏ（−Ｂ１０３８−Ｏ）_i−Ｈ（ｉ＝１、２、３、４、５）、−Ｏ（−Ｂ１０３９−Ｏ）_i−Ｂ１０４０（ｉ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ１０４１、−ＯＣ（Ｏ）−Ｏ−Ｂ１０４２、−ＯＣ（Ｏ）−ＮＨＢ１０４３、−Ｏ−Ｃ（Ｏ）−ＮＢ１０４４Ｂ１０４５、−ＯＰ（Ｏ）（ＯＢ１０４６）（ＯＢ１０４７）、−ＯＳｉ（Ｂ１０４８）（Ｂ１０４９）（Ｂ１０５０）、−ＯＳ（Ｏ₂）−Ｂ１０５１、−ＮＨＣ（Ｏ）−Ｂ１０５２、−ＮＢ１０５３Ｃ（Ｏ）−Ｂ１０５４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ１０５５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ１０５６、−ＮＨ−Ｃ（Ｏ）−ＮＢ１０５７Ｂ１０５８、−ＮＢ１０５９−Ｃ（Ｏ）−Ｏ−Ｂ１０６０、−ＮＢ１０６１−Ｃ（Ｏ）−ＮＨ−Ｂ１０６２、−ＮＢ１０６３−Ｃ（Ｏ）−ＮＢ１０６４Ｂ１０６５、−ＮＨＳ（Ｏ₂）−Ｂ１０６６、−ＮＢ１０６７Ｓ（Ｏ₂）−Ｂ１０６８、−Ｓ−Ｂ１０６９、−Ｓ（Ｏ）−Ｂ１０７０、−Ｓ（Ｏ₂）−Ｂ１０７１、−Ｓ（Ｏ₂）ＮＨ−Ｂ１０７２、−Ｓ（Ｏ₂）ＮＢ１０７３Ｂ１０７４、−Ｓ（Ｏ₂）Ｏ−Ｂ１０７５、−Ｐ（Ｏ）（ＯＢ１０７６）（ＯＢ１０７７）、−Ｓｉ（Ｂ１０７８）（Ｂ１０７９）（Ｂ１０８０）"；
その際、Ｂ１０２９、Ｂ１０３０、Ｂ１０３１、Ｂ１０３２、Ｂ１０３３、Ｂ１０３４、Ｂ１０３５、Ｂ１０３６、Ｂ１０３７、Ｂ１０３８、Ｂ１０３９、Ｂ１０４０、Ｂ１０４１、Ｂ１０４２、Ｂ１０４３、Ｂ１０４４、Ｂ１０４５、Ｂ１０４６、Ｂ１０４７、Ｂ１０４８、Ｂ１０４９、Ｂ１０５０、Ｂ１０５１、Ｂ１０５２、Ｂ１０５３、Ｂ１０５４、Ｂ１０５５、Ｂ１０５６、Ｂ１０５７、Ｂ１０５８、Ｂ１０５９、Ｂ１０６０、Ｂ１０６１、Ｂ１０６２、Ｂ１０６３、Ｂ１０６４、Ｂ１０６５、Ｂ１０６６、Ｂ１０６７、Ｂ１０６８、Ｂ１０６９、Ｂ１０７０、Ｂ１０７１、Ｂ１０７２、Ｂ１０７３、Ｂ１０７４、Ｂ１０７５、Ｂ１０７６、Ｂ１０７７、Ｂ１０７８、Ｂ１０７９、Ｂ１０８０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ１０３５、Ｂ１０３６及び／又はＢ１０４４、Ｂ１０４５及び／又はＢ１０５７、Ｂ１０５８及び／又はＢ１０６４、Ｂ１０６５及び／又はＢ１０７３、Ｂ１０７４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ１０８１、−ＮＢ１０８２Ｂ１０８３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ１０８４、−Ｃ（Ｏ）Ｏ−Ｂ１０８５、−Ｃ（Ｏ）ＮＨ−Ｂ１０８６、−Ｃ（Ｏ）ＮＢ１０８７Ｂ１０８８、−Ｏ−Ｂ１０８９、−Ｏ（−Ｂ１０９０−Ｏ）_j−Ｈ（ｊ＝１、２、３、４、５）、−Ｏ（−Ｂ１０９１−Ｏ）_j−Ｂ１０９２（ｊ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ１０９３、−ＯＣ（Ｏ）−Ｏ−Ｂ１０９４、−ＯＣ（Ｏ）−ＮＨＢ１０９５、−Ｏ−Ｃ（Ｏ）−ＮＢ１０９６Ｂ１０９７、−ＯＰ（Ｏ）（ＯＢ１０９８）（ＯＢ１０９９）、−ＯＳｉ（Ｂ１１００）（Ｂ１１０１）（Ｂ１１０２）、−ＯＳ（Ｏ₂）−Ｂ１１０３、−ＮＨＣ（Ｏ）−Ｂ１１０４、−ＮＢ１１０５Ｃ（Ｏ）−Ｂ１１０６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ１１０７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ１１０８、−ＮＨ−Ｃ（Ｏ）−ＮＢ１１０９Ｂ１１１０、−ＮＢ１１１１−Ｃ（Ｏ）−Ｏ−Ｂ１１１２、−ＮＢ１１１３−Ｃ（Ｏ）−ＮＨ−Ｂ１１１４、−ＮＢ１１１５−Ｃ（Ｏ）−ＮＢ１１１６Ｂ１１１７、−ＮＨＳ（Ｏ₂）−Ｂ１１１８、−ＮＢ１１１９Ｓ（Ｏ₂）−Ｂ１１２０、−Ｓ−Ｂ１１２１、−Ｓ（Ｏ）−Ｂ１１２２、−Ｓ（Ｏ₂）−Ｂ１１２３、−Ｓ（Ｏ₂）ＮＨ−Ｂ１１２４、−Ｓ（Ｏ₂）ＮＢ１１２５Ｂ１１２６、−Ｓ（Ｏ₂）Ｏ−Ｂ１１２７、−Ｐ（Ｏ）（ＯＢ１１２８）（ＯＢ１１２９）、−Ｓｉ（Ｂ１１３０）（Ｂ１１３１）（Ｂ１１３２）"；
その際、Ｂ１０８１、Ｂ１０８２、Ｂ１０８３、Ｂ１０８４、Ｂ１０８５、Ｂ１０８６、Ｂ１０８７、Ｂ１０８８、Ｂ１０８９、Ｂ１０９０、Ｂ１０９１、Ｂ１０９２、Ｂ１０９３、Ｂ１０９４、Ｂ１０９５、Ｂ１０９６、Ｂ１０９７、Ｂ１０９８、Ｂ１０９９、Ｂ１１００、Ｂ１１０１、Ｂ１１０２、Ｂ１１０３、Ｂ１１０４、Ｂ１１０５、Ｂ１１０６、Ｂ１１０７、Ｂ１１０８、Ｂ１１０９、Ｂ１１１０、Ｂ１１１１、Ｂ１１１２、Ｂ１１１３、Ｂ１１１４、Ｂ１１１５、Ｂ１１１６、Ｂ１１１７、Ｂ１１１８、Ｂ１１１９、Ｂ１１２０、Ｂ１１２１、Ｂ１１２２、Ｂ１１２３、Ｂ１１２４、Ｂ１１２５、Ｂ１１２６、Ｂ１１２７、Ｂ１１２８、Ｂ１１２９、Ｂ１１３０、Ｂ１１３１、Ｂ１１３２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ１０８７、Ｂ１０８８及び／又はＢ１０９６、Ｂ１０９７及び／又はＢ１１０９、Ｂ１１１０及び／又はＢ１１１６、Ｂ１１１７及び／又はＢ１１２５、Ｂ１１２６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
（ｍ）ＮＺ８Ｚ９、
その際、Ｚ８、Ｚ９は、互いに無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、−Ｃ（Ｏ）−Ｂ１１３３、−Ｃ（Ｏ）Ｏ−Ｂ１１３４、−Ｃ（Ｏ）−ＮＢ１１３５Ｂ１１３６、−Ｓ（Ｏ₂）−Ｂ１１３７、−Ｓ（Ｏ₂）Ｏ−Ｂ１１３８"；
その際、Ｂ１１３３、Ｂ１１３４、Ｂ１１３５、Ｂ１１３６、Ｂ１１３７、Ｂ１１３８は、互いに無関係に、"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的に、Ｂ１１３５、Ｂ１１３６は、一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ１１３９、−ＮＢ１１４０Ｂ１１４１、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ１１４２、−Ｃ（Ｏ）Ｏ−Ｂ１１４３、−Ｃ（Ｏ）ＮＨ−Ｂ１１４４、−Ｃ（Ｏ）ＮＢ１１４５Ｂ１１４６、−Ｏ−Ｂ１１４７、−Ｏ（−Ｂ１１４８−Ｏ）_k−Ｈ（ｋ＝１、２、３、４、５）、−Ｏ（−Ｂ１１４９−Ｏ）_k−Ｂ１１５０（ｋ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ１１５１、−ＯＣ（Ｏ）−Ｏ−Ｂ１１５２、−ＯＣ（Ｏ）−ＮＨＢ１１５３、−Ｏ−Ｃ（Ｏ）−ＮＢ１１５４Ｂ１１５５、−ＯＰ（Ｏ）（ＯＢ１１５６）（ＯＢ１１５７）、−ＯＳｉ（Ｂ１１５８）（Ｂ１１５９）（Ｂ１１６０）、−ＯＳ（Ｏ₂）−Ｂ１１６１、−ＮＨＣ（Ｏ）−Ｂ１１６２、−ＮＢ１１６３Ｃ（Ｏ）−Ｂ１１６４、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ１１６５、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ１１６６、−ＮＨ−Ｃ（Ｏ）−ＮＢ１１６７Ｂ１１６８、−ＮＢ１１６９−Ｃ（Ｏ）−Ｏ−Ｂ１１７０、−ＮＢ１１７１−Ｃ（Ｏ）−ＮＨ−Ｂ１１７２、−ＮＢ１１７３−Ｃ（Ｏ）−ＮＢ１１７４Ｂ１１７５、−ＮＨＳ（Ｏ₂）−Ｂ１１７６、−ＮＢ１１７７Ｓ（Ｏ₂）−Ｂ１１７８、−Ｓ−Ｂ１１７９、−Ｓ（Ｏ）−Ｂ１１８０、−Ｓ（Ｏ₂）−Ｂ１１８１、−Ｓ（Ｏ₂）ＮＨ−Ｂ１１８２、−Ｓ（Ｏ₂）ＮＢ１１８３Ｂ１１８４、−Ｓ（Ｏ₂）Ｏ−Ｂ１１８５、−Ｐ（Ｏ）（ＯＢ１１８６）（ＯＢ１１８７）、−Ｓｉ（Ｂ１１８８）（Ｂ１１８９）（Ｂ１１９０）"；
その際、Ｂ１１３９、Ｂ１１４０、Ｂ１１４１、Ｂ１１４２、Ｂ１１４３、Ｂ１１４４、Ｂ１１４５、Ｂ１１４６、Ｂ１１４７、Ｂ１１４８、Ｂ１１４９、Ｂ１１５０、Ｂ１１５１、Ｂ１１５２、Ｂ１１５３、Ｂ１１５４、Ｂ１１５５、Ｂ１１５６、Ｂ１１５７、Ｂ１１５８、Ｂ１１５９、Ｂ１１６０、Ｂ１１６１、Ｂ１１６２、Ｂ１１６３、Ｂ１１６４、Ｂ１１６５、Ｂ１１６６、Ｂ１１６７、Ｂ１１６８、Ｂ１１６９、Ｂ１１７０、Ｂ１１７１、Ｂ１１７２、Ｂ１１７３、Ｂ１１７４、Ｂ１１７５、Ｂ１１７６、Ｂ１１７７、Ｂ１１７８、Ｂ１１７９、Ｂ１１８０、Ｂ１１８１、Ｂ１１８２、Ｂ１１８３、Ｂ１１８４、Ｂ１１８５、Ｂ１１８６、Ｂ１１８７、Ｂ１１８８、Ｂ１１８９、Ｂ１１９０は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ１１４５、Ｂ１１４６及び／又はＢ１１５４、Ｂ１１５５及び／又はＢ１１６７、Ｂ１１６８及び／又はＢ１１７４、Ｂ１１７５及び／又はＢ１１８３、Ｂ１１８４は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＢ１１９１、−ＮＢ１１９２Ｂ１１９３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｂ１１９４、−Ｃ（Ｏ）Ｏ−Ｂ１１９５、−Ｃ（Ｏ）ＮＨ−Ｂ１１９６、−Ｃ（Ｏ）ＮＢ１１９７Ｂ１１９８、−Ｏ−Ｂ１１９９、−Ｏ（−Ｂ１２００−Ｏ）_l−Ｈ（ｌ＝１、２、３、４、５）、−Ｏ（−Ｂ１２０１−Ｏ）_l−Ｂ１２０２（ｌ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｂ１２０３、−ＯＣ（Ｏ）−Ｏ−Ｂ１２０４、−ＯＣ（Ｏ）−ＮＨＢ１２０５、−Ｏ−Ｃ（Ｏ）−ＮＢ１２０６Ｂ１２０７、−ＯＰ（Ｏ）（ＯＢ１２０８）（ＯＢ１２０９）、−ＯＳｉ（Ｂ１２１０）（Ｂ１２１１）（Ｂ１２１２）、−ＯＳ（Ｏ₂）−Ｂ１２１３、−ＮＨＣ（Ｏ）−Ｂ１２１４、−ＮＢ１２１５Ｃ（Ｏ）−Ｂ１２１６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｂ１２１７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｂ１２１８、−ＮＨ−Ｃ（Ｏ）−ＮＢ１２１９Ｂ１２２０、−ＮＢ１２２１−Ｃ（Ｏ）−Ｏ−Ｂ１２２２、−ＮＢ１２２３−Ｃ（Ｏ）−ＮＨ−Ｂ１２２４、−ＮＢ１２２５−Ｃ（Ｏ）−ＮＢ１２２６Ｂ１２２７、−ＮＨＳ（Ｏ₂）−Ｂ１２２８、−ＮＢ１２２９Ｓ（Ｏ₂）−Ｂ１２３０、−Ｓ−Ｂ１２３１、−Ｓ（Ｏ）−Ｂ１２３２、−Ｓ（Ｏ₂）−Ｂ１２３３、−Ｓ（Ｏ₂）ＮＨ−Ｂ１２３４、−Ｓ（Ｏ₂）ＮＢ１２３５Ｂ１２３６、−Ｓ（Ｏ₂）Ｏ−Ｂ１２３７、−Ｐ（Ｏ）（ＯＢ１２３８）（ＯＢ１２３９）、−Ｓｉ（Ｂ１２４０）（Ｂ１２４１）（Ｂ１２４２）"；
その際、Ｂ１１９１、Ｂ１１９２、Ｂ１１９３、Ｂ１１９４、Ｂ１１９５、Ｂ１１９６、Ｂ１１９７、Ｂ１１９８、Ｂ１１９９、Ｂ１２００、Ｂ１２０１、Ｂ１２０２、Ｂ１２０３、Ｂ１２０４、Ｂ１２０５、Ｂ１２０６、Ｂ１２０７、Ｂ１２０８、Ｂ１２０９、Ｂ１２１０、Ｂ１２１１、Ｂ１２１２、Ｂ１２１３、Ｂ１２１４、Ｂ１２１５、Ｂ１２１６、Ｂ１２１７、Ｂ１２１８、Ｂ１２１９、Ｂ１２２０、Ｂ１２２１、Ｂ１２２２、Ｂ１２２３、Ｂ１２２４、Ｂ１２２５、Ｂ１２２６、Ｂ１２２７、Ｂ１２２８、Ｂ１２２９、Ｂ１２３０、Ｂ１２３１、Ｂ１２３２、Ｂ１２３３、Ｂ１２３４、Ｂ１２３５、Ｂ１２３６、Ｂ１２３７、Ｂ１２３８、Ｂ１２３９、Ｂ１２４０、Ｂ１２４１、Ｂ１２４２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＢ１１９７、Ｂ１１９８及び／又はＢ１２０６、Ｂ１２０７及び／又はＢ１２１９、Ｂ１２２０及び／又はＢ１２２６、Ｂ１２２７及び／又はＢ１２３５、Ｂ１２３６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
及び
基Ｚ５は、無関係に、以下のものからなる群から選択される：
（ｉ）"水素、アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＤ１、−ＮＤ２Ｄ３、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｄ４、−Ｃ（Ｏ）Ｏ−Ｄ５、−Ｃ（Ｏ）ＮＨ−Ｄ６、−Ｃ（Ｏ）ＮＤ７Ｄ８、−Ｏ−Ｄ９、−Ｏ（−Ｄ１０−Ｏ）_r−Ｈ（ｒ＝１、２、３、４、５）、−Ｏ（−Ｄ１１−Ｏ）_r−Ｄ１２（ｒ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｄ１３、−ＯＣ（Ｏ）−Ｏ−Ｄ１４、−ＯＣ（Ｏ）−ＮＨＤ１５、−Ｏ−Ｃ（Ｏ）−ＮＤ１６Ｄ１７、−ＯＰ（Ｏ）（ＯＤ１８）（ＯＤ１９）、−ＯＳｉ（Ｄ２０）（Ｄ２１）（Ｄ２２）、−ＯＳ（Ｏ₂）−Ｄ２３、−ＮＨＣ（Ｏ）−Ｄ２４、−ＮＤ２５Ｃ（Ｏ）−Ｄ２６、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｄ２７、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｄ２８、−ＮＨ−Ｃ（Ｏ）−ＮＤ２９Ｄ３０、−ＮＤ３１−Ｃ（Ｏ）−Ｏ−Ｄ３２、−ＮＤ３３−Ｃ（Ｏ）−ＮＨ−Ｄ３４、−ＮＤ３５−Ｃ（Ｏ）−ＮＤ３６Ｄ３７、−ＮＨＳ（Ｏ₂）−Ｄ３８、−ＮＤ３９Ｓ（Ｏ₂）−Ｄ４０、−Ｓ−Ｄ４１、−Ｓ（Ｏ）−Ｄ４２、−Ｓ（Ｏ₂）−Ｄ４３、−Ｓ（Ｏ₂）ＮＨ−Ｄ４４、−Ｓ（Ｏ₂）ＮＤ４５Ｄ４６、−Ｓ（Ｏ₂）Ｏ−Ｄ４７、−Ｐ（Ｏ）（ＯＤ４８）（ＯＤ４９）、−Ｓｉ（Ｄ５０）（Ｄ５１）（Ｄ５２）"；
その際、Ｄ１、Ｄ２、Ｄ３、Ｄ４、Ｄ５、Ｄ６、Ｄ７、Ｄ８、Ｄ９、Ｄ１０、Ｄ１１、Ｄ１２、Ｄ１３、Ｄ１４、Ｄ１５、Ｄ１６、Ｄ１７、Ｄ１８、Ｄ１９、Ｄ２０、Ｄ２１、Ｄ２２、Ｄ２３、Ｄ２４、Ｄ２５、Ｄ２６、Ｄ２７、Ｄ２８、Ｄ２９、Ｄ３０、Ｄ３１、Ｄ３２、Ｄ３３、Ｄ３４、Ｄ３５、Ｄ３６、Ｄ３７、Ｄ３８、Ｄ３９、Ｄ４０、Ｄ４１、Ｄ４２、Ｄ４３、Ｄ４４、Ｄ４５、Ｄ４６、Ｄ４７、Ｄ４８、Ｄ４９、Ｄ５０、Ｄ５１、Ｄ５２は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＤ７、Ｄ８及び／又はＤ１６、Ｄ１７及び／又はＤ２９、Ｄ３０及び／又はＤ３６、Ｄ３７及び／又はＤ４５、Ｄ４６は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＤ５３、−ＮＤ５４Ｄ５５、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｄ５６、−Ｃ（Ｏ）Ｏ−Ｄ５７、−Ｃ（Ｏ）ＮＨ−Ｄ５８、−Ｃ（Ｏ）ＮＤ５９Ｄ６０、−Ｏ−Ｄ６１、−Ｏ（−Ｄ６２−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｄ６３−Ｏ）_t−Ｄ６４（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｄ６５、−ＯＣ（Ｏ）−Ｏ−Ｄ６６、−ＯＣ（Ｏ）−ＮＨＤ６７、−Ｏ−Ｃ（Ｏ）−ＮＤ６８Ｄ６９、−ＯＰ（Ｏ）（ＯＤ７０）（ＯＤ７１）、−ＯＳｉ（Ｄ７２）（Ｄ７３）（Ｄ７４）、−ＯＳ（Ｏ₂）−Ｄ７５、−ＮＨＣ（Ｏ）−Ｄ７６、−ＮＤ７７Ｃ（Ｏ）−Ｄ７８、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｄ７９、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｄ８０、−ＮＨ−Ｃ（Ｏ）−ＮＤ８１Ｄ８２、−ＮＤ８３−Ｃ（Ｏ）−Ｏ−Ｄ８４、−ＮＤ８５−Ｃ（Ｏ）−ＮＨ−Ｄ８６、−ＮＤ８７−Ｃ（Ｏ）−ＮＤ８８Ｄ８９、−ＮＨＳ（Ｏ₂）−Ｄ９０、−ＮＤ９１Ｓ（Ｏ₂）−Ｄ９２、−Ｓ−Ｄ９３、−Ｓ（Ｏ）−Ｄ９４、−Ｓ（Ｏ₂）−Ｄ９５、−Ｓ（Ｏ₂）ＮＨ−Ｄ９６、−Ｓ（Ｏ₂）ＮＤ９７Ｄ９８、−Ｓ（Ｏ₂）Ｏ−Ｄ９９、−Ｐ（Ｏ）（ＯＤ１００）（ＯＤ１０１）、−Ｓｉ（Ｄ１０２）（Ｄ１０３）（Ｄ１０４）"；
その際、Ｄ５３、Ｄ５４、Ｄ５５、Ｄ５６、Ｄ５７、Ｄ５８、Ｄ５９、Ｄ６０、Ｄ６１、Ｄ６２、Ｄ６３、Ｄ６４、Ｄ６５、Ｄ６６、Ｄ６７、Ｄ６８、Ｄ６９、Ｄ７０、Ｄ７１、Ｄ７２、Ｄ７３、Ｄ７４、Ｄ７５、Ｄ７６、Ｄ７７、Ｄ７８、Ｄ７９、Ｄ８０、Ｄ８１、Ｄ８２、Ｄ８３、Ｄ８４、Ｄ８５、Ｄ８６、Ｄ８７、Ｄ８８、Ｄ８９、Ｄ９０、Ｄ９１、Ｄ９２、Ｄ９３、Ｄ９４、Ｄ９５、Ｄ９６、Ｄ９７、Ｄ９８、Ｄ９９、Ｄ１００、Ｄ１０１、Ｄ１０２、Ｄ１０３、Ｄ１０４は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＤ５９、Ｄ６０及び／又はＤ６８、Ｄ６９及び／又はＤ８１、Ｄ８２及び／又はＤ８８、Ｄ８９及び／又はＤ９７、Ｄ９８は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる；
その際、場合により、置換基群（ｉｉ）の前記置換基は、互いに無関係に、同一もしくは異なる、以下のものからなる群から選択される、少なくとも１つの置換基によって更に置換されていてよい：
（ｉｉｉ）"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、Ｎ₃、ＮＨ₂、−ＮＨＤ１０５、−ＮＤ１０６Ｄ１０７、−ＮＯ₂、−ＯＨ、−ＯＣＦ₃、−ＳＨ、−Ｏ−ＳＯ₃Ｈ、−ＯＰ（Ｏ）（ＯＨ）₂、−ＣＨＯ、−ＣＯＯＨ、−Ｃ（Ｏ）ＮＨ₂、−ＳＯ₃Ｈ、−Ｐ（Ｏ）（ＯＨ）₂、−Ｃ（Ｏ）−Ｄ１０８、−Ｃ（Ｏ）Ｏ−Ｄ１０９、−Ｃ（Ｏ）ＮＨ−Ｄ１１０、−Ｃ（Ｏ）ＮＤ１１１Ｄ１１２、−Ｏ−Ｄ１１３、−Ｏ（−Ｄ１１４−Ｏ）_t−Ｈ（ｔ＝１、２、３、４、５）、−Ｏ（−Ｄ１１５−Ｏ）_t−Ｄ１１６（ｔ＝１、２、３、４、５）、−ＯＣ（Ｏ）−Ｄ１１７、−ＯＣ（Ｏ）−Ｏ−Ｄ１１８、−ＯＣ（Ｏ）−ＮＨＤ１１９、−Ｏ−Ｃ（Ｏ）−ＮＤ１２０Ｄ１２１、−ＯＰ（Ｏ）（ＯＤ１２２）（ＯＤ１２３）、−ＯＳｉ（Ｄ１２４）（Ｄ１２５）（Ｄ１２６）、−ＯＳ（Ｏ₂）−Ｄ１２７、−ＮＨＣ（Ｏ）−Ｄ１２８、−ＮＤ１２９Ｃ（Ｏ）−Ｄ１３０、−ＮＨ−Ｃ（Ｏ）−Ｏ−Ｄ１３１、−ＮＨ−Ｃ（Ｏ）−ＮＨ−Ｄ１３２、−ＮＨ−Ｃ（Ｏ）−ＮＤ１３３Ｄ１３４、−ＮＤ１３５−Ｃ（Ｏ）−Ｏ−Ｄ１３６、−ＮＤ１３７−Ｃ（Ｏ）−ＮＨ−Ｄ１３８、−ＮＤ１３９−Ｃ（Ｏ）−ＮＤ１４０Ｄ１４１、−ＮＨＳ（Ｏ₂）−Ｄ１４２、−ＮＤ１４３Ｓ（Ｏ₂）−Ｄ１４４、−Ｓ−Ｄ１４５、−Ｓ（Ｏ）−Ｄ１４６、−Ｓ（Ｏ₂）−Ｄ１４７、−Ｓ（Ｏ₂）ＮＨ−Ｄ１４８、−Ｓ（Ｏ₂）ＮＤ１４９Ｄ１５０、−Ｓ（Ｏ₂）Ｏ−Ｄ１５１、−Ｐ（Ｏ）（ＯＤ１５２）（ＯＤ１５３）、−Ｓｉ（Ｄ１５４）（Ｄ１５５）（Ｄ１５６）"；
その際、Ｄ１０５、Ｄ１０６、Ｄ１０７、Ｄ１０８、Ｄ１０９、Ｄ１１０、Ｄ１１１、Ｄ１１２、Ｄ１１３、Ｄ１１４、Ｄ１１５、Ｄ１１６、Ｄ１１７、Ｄ１１８、Ｄ１１９、Ｄ１２０、Ｄ１２１、Ｄ１２２、Ｄ１２３、Ｄ１２４、Ｄ１２５、Ｄ１２６、Ｄ１２７、Ｄ１２８、Ｄ１２９、Ｄ１３０、Ｄ１３１、Ｄ１３２、Ｄ１３３、Ｄ１３４、Ｄ１３５、Ｄ１３６、Ｄ１３７、Ｄ１３８、Ｄ１３９、Ｄ１４０、Ｄ１４１、Ｄ１４２、Ｄ１４３、Ｄ１４４、Ｄ１４５、Ｄ１４６、Ｄ１４７、Ｄ１４８、Ｄ１４９、Ｄ１５０、Ｄ１５１、Ｄ１５２、Ｄ１５３、Ｄ１５４、Ｄ１５５、Ｄ１５６は、互いに無関係に、"アルキル、Ｃ₉〜Ｃ₃₀−アルキル、シクロアルキル、シクロアルキルアルキル、ヘテロシクリル、ヘテロシクリルアルキル、アリール、アリールアルキル、ヘテロアリール、ヘテロアリールアルキル"からなる群から選択され、かつ選択的にＤ１１１、Ｄ１１２及び／又はＤ１２０、Ｄ１２１及び／又はＤ１３３、Ｄ１３４及び／又はＤ１４０、Ｄ１４１及び／又はＤ１４９、Ｄ１５０は、それぞれ一緒になって、"ヘテロシクリル"を形成することもできる］による一連のピリド［２，３−ｂ］ピラジンからの新規化合物を記載する。 A first aspect of the present application is the general formula (I)

[Where:
(A)
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are “substituted aryl”, wherein “substituted aryl” is the same or different from the group consisting of: Substituted with at least one selected substituent:
(A) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-X1, -N (alkyl) ₂ , —NHC (O) -alkyl, —NHC (O) -cycloalkyl, —NHC (O) -heterocyclyl, —NHC (O) -aryl, —NHC (O) -heteroaryl, —NHC (O) -aryl Alkyl, -NHC (O) -heteroarylalkyl, -NHS (O ₂ ) -Alkyl, -NHS (O ₂ ) -Cycloalkyl, -NHS (O ₂ ) -Heterocyclyl, -NHS (O ₂ ) -Aryl, -NHS (O ₂ ) -Heteroaryl, -NHS (O ₂ ) -Arylalkyl, -NHS (O ₂ ) -Heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -O-X2, -OC (O) -alkyl, -OC (O) -cycloalkyl, -OC (O)- Heterocyclyl, -OC (O) -aryl, -OC (O) -heteroaryl, -OC (O) -arylalkyl, -OC (O) -heteroarylalkyl, -OS (O ₂ ) -Alkyl, -OS (O ₂ ) -Cycloalkyl, -OS (O ₂ ) -Heterocyclyl, -OS (O ₂ ) -Aryl, -OS (O ₂ ) -Heteroaryl, -OS (O ₂ ) -Arylalkyl, -OS (O ₂ ) -Heteroarylalkyl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl, -C (O) O-X3, -C (O) NH-X4,- C (O) N (alkyl) ₂ , -C (O) N (cycloalkyl) ₂ , -C (O) N (aryl) ₂ , -C (O) N (heteroaryl) ₂ , -S (O) -alkyl, -S (O) -aryl, -S (O ₂ ) -Alkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) NH-alkyl, -S (O ₂ ) NH-aryl, -S (O ₂ ) NH-heteroaryl, -S (O ₂ ) NH-arylalkyl, S (O ₂ ) O-alkyl, -S (O ₂ ) O-aryl, -S (O ₂ ) O-arylalkyl ";
Wherein X1, X2, X3, X4 are independently selected from the group consisting of “alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl”;
However, the above substituents of the substituent group (a) are further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N _Three , -NH-cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NX5X6, -S- Cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -O-cycloalkyl , -O-cycloalkylalkyl, -O-arylalkyl, -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclyl, -O-heterocyclylalkyl, -O (-X7-O) _p -X8 (p = 1, 2, 3, 4, 5), -OP (O) (OX9) (OX10), -C (O) O-X11, -C (O) NH ₂ , -C (O) NH-X12, -C (O) NX13X14, -S (O ₂ ) -X15, -P (O) (OH) ₂ , -P (O) (OX16) (OX17), -Si (X18) (X19) (X20), -O-Si (X21) (X22) (X23), -O-C (O) -O-X24 , -O-C (O) -NH-X25, -O-C (O) -NX26X27, -NH-C (O) -O-X28, -NH-C (O) -NH-X29, -NH- C (O) -NX30X31, -NX32-C (O) -O-X33, -NX34-C (O) -NH-X35, -NX36-C (O) -NX37X38, -O-S (O ₂ ) -X39, -NH-C (O) -X40, -NX41-C (O) -X42, -C (O) -X43, -OC (O) -X44, -S (O) -X45, -S (O ₂ ) -NHX46, -S (O ₂ ) -NX47X48, -S (O ₂ ) -OX49, -O (-X50-O) _p -H (p = 1, 2, 3, 4, 5) ";
However, in addition, “—N (alkyl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (b);
At that time, X5, X6, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, X18, X19, X20, X21, X22, X23, X24, X25, X26, X27, X28 X29, X30, X31, X32, X33, X34, X35, X36, X37, X38, X39, X40, X41, X42, X43, X44, X45, X46, X47, X48, X49, X50 are independent of each other. "Alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, X13, X14 and / or X26, X27 and / or Or X30, X31 and / or X37, X38 and / or X47, X48 may be taken together to form a "heterocyclyl";
However, when one of the groups Z3 or Z4 is “substituted aryl” substituted by “heterocyclylalkyl”, the other group Z3 or Z4 is not “substituted or unsubstituted aryl”, respectively. ;
In that case, optionally additionally, one of the groups Z3, Z4, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(B) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX51, -NX52X53, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X54, -C (O) O-X55, -C (O) NH-X56, -C (O) NX57X58, -O-X59, -O (-X60-O) _r -H (r = 1, 2, 3, 4, 5), -O (-X61-O) _r -X62 (r = 1, 2, 3, 4, 5), -OC (O) -X63, -OC (O) -O-X64, -OC (O) -NHX65, -O-C (O)- NX66X67, -OP (O) (OX68) (OX69), -OSi (X70) (X71) (X72), -OS (O ₂ ) -X73, -NHC (O) -X74, -NX75C (O) -X76, -NH-C (O) -O-X77, -NH-C (O) -NH-X78, -NH-C (O ) -NX79X80, -NX81-C (O) -O-X82, -NX83-C (O) -NH-X84, -NX85-C (O) -NX86X87, -NHS (O ₂ ) -X88, -NX89S (O ₂ ) -X90, -S-X91, -S (O) -X92, -S (O ₂ ) -X93, -S (O ₂ ) NH-X94, -S (O ₂ ) NX95X96, -S (O ₂ ) O-X97, -P (O) (OX98) (OX99), -Si (X100) (X101) (X102) ";
At that time, X51, X52, X53, X54, X55, X56, X57, X58, X59, X60, X61, X62, X63, X64, X65, X66, X67, X68, X69, X70, X71, X72, X73, X74 X75, X76, X77, X78, X79, X80, X81, X82, X83, X84, X85, X86, X87, X88, X89, X90, X91, X92, X93, X94, X95, X96, X97, X98, X99 , X100, X101, X102 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X57, X58 and / or X66, X67 and / or X79, X80 and / or X86, X87 and / or X95, X96 may be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (b) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX103, -NX104X105, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X106, -C (O) O-X107, -C (O) NH-X108, -C (O) NX109X110, -O-X111, -O (-X112-O) _s -H (s = 1, 2, 3, 4, 5), -O (-X113-O) _s -X114 (s = 1, 2, 3, 4, 5), -OC (O) -X115, -OC (O) -O-X116, -OC (O) -NHX117, -O-C (O)- NX118X119, -OP (O) (OX120) (OX121), -OSi (X122) (X123) (X124), -OS (O ₂ ) -X125, -NHC (O) -X126, -NX127C (O) -X128, -NH-C (O) -O-X129, -NH-C (O) -NH-X130, -NH-C (O ) -NX131X132, -NX133-C (O) -O-X134, -NX135-C (O) -NH-X136, -NX137-C (O) -NX138X139, -NHS (O ₂ ) -X140, -NX141S (O ₂ ) -X142, -S-X143, -S (O) -X144, -S (O ₂ ) -X145, -S (O ₂ ) NH-X146, -S (O ₂ ) NX147X148, -S (O ₂ ) O-X149, -P (O) (OX150) (OX151), -Si (X152) (X153) (X154) ";
At that time, X103, X104, X105, X106, X107, X108, X109, X110, X111, X112, X113, X114, X115, X116, X117, X118, X119, X120, X121, X122, X123, X124, X125, X126 , X127, X128, X129, X130, X131, X132, X133, X134, X135, X136, X137, X138, X139, X140, X141, X142, X143, X144, X145, X146, X147, X148, X149, X150, X151 , X152, X153, X154 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X109, X110 and / or X118, X119 and / or X131, X132 and / or X138, X139 and / or X147, X148 may be taken together to form "heterocyclyl";
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX155, -NX156X157, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X158, -C (O) O-X159, -C (O) NH-X160, -C (O) NX161X162, -O-X163, -O (-X164-O) _t -H (t = 1, 2, 3, 4, 5), -O (-X165-O) _t -X166 (t = 1, 2, 3, 4, 5), -OC (O) -X167, -OC (O) -O-X168, -OC (O) -NHX169, -O-C (O)- NX170X171, -OP (O) (OX172) (OX173), -OSi (X174) (X175) (X176), -OS (O ₂ ) -X177, -NHC (O) -X178, -NX179C (O) -X180, -NH-C (O) -O-X181, -NH-C (O) -NH-X182, -NH-C (O ) -NX183X184, -NX185-C (O) -O-X186, -NX187-C (O) -NH-X188, -NX189-C (O) -NX190X191, -NHS (O ₂ ) -X192, -NX193S (O ₂ ) -X194, -S-X195, -S (O) -X196, -S (O ₂ ) -X197, -S (O ₂ ) NH-X198, -S (O ₂ ) NX199X200, -S (O ₂ ) O-X201, -P (O) (OX202) (OX203), -Si (X204) (X205) (X206) ";
At that time, X155, X156, X157, X158, X159, X160, X161, X162, X163, X164, X165, X166, X167, X168, X169, X170, X171, X172, X173, X174, X175, X176, X177, X178 , X179, X180, X181, X182, X183, X184, X185, X186, X187, X188, X189, X190, X191, X192, X193, X194, X195, X196, X197, X198, X199, X200, X201, X202, X203 , X204, X205, X206 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X161, X162 and / or X170, X171 and / or X183, X184 and / or X190, X191 and / or X199, X200 may be taken together to form a "heterocyclyl";
Or
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are “substituted aryl”, wherein “substituted aryl” is the same or different from the group consisting of: Substituted with at least one selected substituent:
(C) "C ₉ ~ C ₃₀ -Alkyl, -NX207X208, -NH-C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -cycloalkylalkyl, -NHC (O) -heterocyclylalkyl, -NHC (O) -C ₉ ~ C ₃₀ -Alkyl, -NX209C (O) -X210, -NX211C (O) -C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -OX212, -NX213C (O) -OX214, -NHC (O) -NHX215, -NHC (O) -NX216X217, -NX218C (O) -NHX219, -NX220C (O) -NX221X222 , -NHS (O ₂ ) -Cycloalkylalkyl, -NHS (O ₂ ) -Heterocyclylalkyl, -NX223S (O ₂ ) -X224, -O-C ₉ ~ C ₃₀ -Alkyl, -S-cycloalkyl, -S-heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S-cycloalkylalkyl, -S-heterocyclylalkyl, -S-C ₉ ~ C ₃₀ -Alkyl, -OC (O) -cycloalkylalkyl, -OC (O) -heterocyclylalkyl, -OC (O) -C ₉ ~ C ₃₀ -Alkyl, -OS (O ₂ ) -Cycloalkylalkyl, -OS (O ₂ ) -Heterocyclylalkyl, -OS (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -OC (O) -OX225, -OC (O) -NHX226, -OC (O) -NX227X228, -OP (O) (OX229) (OX230), -C (O) -cycloalkyl, -C (O) -heterocyclyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -C (O) -cycloalkylalkyl, -C (O) -heterocyclylalkyl, -C (O)- C ₉ ~ C ₃₀ -Alkyl, -C (O) O-C ₉ ~ C ₃₀ -Alkyl, -C (O) NH-C ₉ ~ C ₃₀ -Alkyl, -C (O) NX231X232, -C (O) NH-OX233, -C (O) NX234-OX235, -C (O) NH-NX236X237, -C (O) NX238-NX239X240, -S (O ) -Cycloalkyl, -S (O) -heterocyclyl, -S (O) -heteroaryl, -S (O) -arylalkyl, -S (O) -heteroarylalkyl, -S (O) -cycloalkylalkyl , -S (O) -heterocyclylalkyl, -S (O) -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Heterocyclylalkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) NH-cycloalkyl, -S (O ₂ ) NH-heterocyclyl, -S (O ₂ ) NH-heteroarylalkyl, -S (O ₂ ) NH-cycloalkylalkyl, -S (O ₂ ) NH-heterocyclylalkyl, -S (O ₂ ) NH-C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) O-cycloalkyl, -S (O ₂ ) O-heterocyclyl, -S (O ₂ ) O-heteroaryl, -S (O ₂ ) O-heteroarylalkyl, -S (O ₂ ) O-cycloalkylalkyl, -S (O ₂ ) O-heterocyclylalkyl, -S (O ₂ ) O-C ₉ ~ C ₃₀ -Alkyl, -P (O) (OH) ₂ , -P (O) (OX241) (OX242), -Si (X243) (X244) (X245), -O-Si (X246) (X247) (X248) ";
In that case, X207, X208, X209, X210, X211, X212, X213, X214, X215, X216, X217, X218, X219, X220, X221, X222, X223, X224, X225, X226, X227, X228, X229, X230 , X231, X232, X233, X234, X235, X236, X237, X238, X239, X240, X241, X242, X243, X244, X245, X246, X247, X248 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, X216, X217 and / or X221, X222 and / or Or X227, X228 and / or X231, X232 and / or X236, X237 and / or X239, X240 may each be taken together to form a "heterocyclyl";
Provided that the substituent "-N (alkyl) ₂ ","-C (O) N (alkyl) ₂ ","-C (O) N (cycloalkyl) ₂ ","-C (O) N (aryl) ₂ ","-C (O) N (heteroaryl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (i);
However, when one of the groups Z3 or Z4 is “substituted aryl” substituted by “heterocyclylalkyl”, the other group Z3 or Z4 is not “substituted or unsubstituted aryl”, respectively. ;
In this case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX249, -NX250X251, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X252, -C (O) O-X253, -C (O) NH-X254, -C (O) NX255X256, -O-X257, -O (-X258-O) _u -H (u = 1, 2, 3, 4, 5), -O (-X259-O) _u -X260 (u = 1, 2, 3, 4, 5), -OC (O) -X261, -OC (O) -O-X262, -OC (O) -NHX263, -O-C (O)- NX264X265, -OP (O) (OX266) (OX267), -OSi (X268) (X269) (X270), -OS (O ₂ ) -X271, -NHC (O) -X272, -NX273C (O) -X274, -NH-C (O) -O-X275, -NH-C (O) -NH-X276, -NH-C (O ) -NX277X278, -NX279-C (O) -O-X280, -NX281-C (O) -NH-X282, -NX283-C (O) -NX284X285, -NHS (O ₂ ) -X286, -NX287S (O ₂ ) -X288, -S-X289, -S (O) -X290, -S (O ₂ ) -X291, -S (O ₂ ) NH-X292, -S (O ₂ ) NX293X294, -S (O ₂ ) O-X295, -P (O) (OX296) (OX297), -Si (X298) (X1299) (X300) ";
At that time, X249, X250, X251, X252, X253, X254, X255, X256, X257, X258, X259, X260, X261, X262, X263, X264, X265, X266, X267, X268, X269, X270, X271, X272 , X273, X274, X275, X276, X277, X278, X279, X280, X281, X282, X283, X284, X285, X286, X287, X288, X289, X290, X291, X292, X293, X294, X295,9729 , X298, X299, X300 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X255, X256 and / or X264, X265 and / or X277, X278 and / or X284, X285 and / or X293, X294 may be taken together to form a “heterocyclyl”;
In that case, optionally, one of the groups Z3, Z3, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(D) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX301, -NX302X303, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X304, -C (O) O-X305, -C (O) NH-X306, -C (O) NX307X308, -O-X309, -O (-X310-O) _uu -H (uu = 1, 2, 3, 4, 5), -O (-X311-O) _uu -X312 (uu = 1, 2, 3, 4, 5), -OC (O) -X313, -OC (O) -O-X314, -OC (O) -NHX315, -O-C (O)- NX316X317, -OP (O) (OX318) (OX319), -OSi (X320) (X321) (X322), -OS (O ₂ ) -X323, -NHC (O) -X324, -NX325C (O) -X326, -NH-C (O) -O-X327, -NH-C (O) -NH-X328, -NH-C (O ) -NX329X330, -NX331-C (O) -O-X332, -NX333-C (O) -NH-X334, -NX335-C (O) -NX336X337, -NHS (O ₂ ) -X338, -NX339S (O ₂ ) -X340, -S-X341, -S (O) -X342, -S (O ₂ ) -X343, -S (O ₂ ) NH-X344, -S (O ₂ ) NX345X346, -S (O ₂ ) O-X347, -P (O) (OX348) (OX349), -Si (X350) (X351) (X352) ";
At that time, X301, X302, X303, X304, X305, X306, X307, X308, X309, X310, X311, X312, X313, X314, X315, X316, X317, X318, X319, X320, X321, X322, X323, X324 , X325, X326, X327, X328, X329, X330, X331, X332, X333, X334, X335, X336, X337, X338, X339, X340, X341, X342, X343, X344, X345, X346, X347, X348, , X350, X351, X352 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X307, X308 and / or X316, X317 and / or X329, X330 and / or X336, X337 and / or X345, X346 may be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (d) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX353, -NX354X355, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X356, -C (O) O-X357, -C (O) NH-X358, -C (O) NX359X360, -O-X361, -O (-X362-O) _v -H (v = 1, 2, 3, 4, 5), -O (-X363-O) _v -X364 (v = 1, 2, 3, 4, 5), -OC (O) -X365, -OC (O) -O-X366, -OC (O) -NHX367, -O-C (O)- NX368X369, -OP (O) (OX370) (OX371), -OSi (X372) (X373) (X374), -OS (O ₂ ) -X375, -NHC (O) -X376, -NX377C (O) -X378, -NH-C (O) -O-X379, -NH-C (O) -NH-X380, -NH-C (O ) -NX381X382, -NX383-C (O) -O-X384, -NX385-C (O) -NH-X386, -NX387-C (O) -NX388X389, -NHS (O ₂ ) -X390, -NX391S (O ₂ ) -X392, -S-X393, -S (O) -X394, -S (O ₂ ) -X395, -S (O ₂ ) NH-X396, -S (O ₂ ) NX397X398, -S (O ₂ ) O-X399, -P (O) (OX400) (OX401), -Si (X402) (X403) (X404) ";
At that time, X353, X354, X355, X356, X357, X358, X359, X360, X361, X362, X363, X364, X365, X366, X367, X368, X369, X370, X371, X372, X373, X375, X376 X377, X378, X379, X380, X381, X382, X383, X384, X385, X386, X387, X388, X389, X390, X391, X392, X393, X394, X395, X396, X397, X398, X399, X398, X399 , X402, X403, and X404 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X359, X360 and / or X368, X369 and / or X381, X382 and / or X388, X389 and / or X397, X398 may be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX405, -NX406X407, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X408, -C (O) O-X409, -C (O) NH-X410, -C (O) NX411X412, -O-X413, -O (-X414-O) _w -H (w = 1, 2, 3, 4, 5), -O (-X415-O) _w -X416 (w = 1, 2, 3, 4, 5), -OC (O) -X417, -OC (O) -O-X418, -OC (O) -NHX419, -O-C (O)- NX420X421, -OP (O) (OX422) (OX423), -OSi (X424) (X425) (X426), -OS (O ₂ ) -X427, -NHC (O) -X428, -NX429C (O) -X430, -NH-C (O) -O-X431, -NH-C (O) -NH-X432, -NH-C (O ) -NX433X434, -NX435-C (O) -O-X436, -NX437-C (O) -NH-X438, -NX439-C (O) -NX440X441, -NHS (O ₂ ) -X442, -NX443S (O ₂ ) -X444, -S-X445, -S (O) -X446, -S (O ₂ ) -X447, -S (O ₂ ) NH-X448, -S (O ₂ ) NX449X450, -S (O ₂ ) O-X451, -P (O) (OX452) (OX453), -Si (X454) (X455) (X456) ";
At that time, X405, X406, X407, X408, X409, X410, X411, X412, X413, X414, X415, X416, X417, X418, X419, X420, X421, X422, X423, X424, X425, X426, X427, X428 , X429, X430, X431, X432, X433, X434, X435, X436, X437, X438, X439, X440, X441, X442, X443, X444, X445, X446, X447, X448, X449, X450, X451, X452, , X454, X455, X456 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X411, X412 and / or X420, X421 and / or X433, X434 and / or X440, X441 and / or X449, X450 can be taken together to form a "heterocyclyl";
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(E) hydrogen;
(F) halogen, F, Cl, Br, I;
(G) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX457, -NX458X459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X460, -C (O) O-X461, -C (O) NH-X462, -C (O) NX463X464, -O-X465, -O (-X466-O) _x -H (x = 1, 2, 3, 4, 5), -O (-X467-O) _x -X468 (x = 1, 2, 3, 4, 5), -OC (O) -X469, -OC (O) -O-X470, -OC (O) -NHX471, -O-C (O)- NX472X473, -OP (O) (OX474) (OX475), -OSi (X476) (X477) (X478), -OS (O ₂ ) -X479, -NHC (O) -X480, -NX481C (O) -X482, -NH-C (O) -O-X483, -NH-C (O) -NH-X484, -NH-C (O ) -NX485X486, -NX487-C (O) -O-X488, -NX489-C (O) -NH-X490, -NX491-C (O) -NX492X493, -NHS (O ₂ ) -X494, -NX495S (O ₂ ) -X496, -S-X497, -S (O) -X498, -S (O ₂ ) -X499, -S (O ₂ ) NH-X500, -S (O ₂ ) NX501X502, -S (O ₂ ) O-X503, -P (O) (OX504) (OX505), -Si (X506) (X507) (X508) ";
At that time, X457, X458, X459, X460, X461, X462, X463, X464, X465, X466, X467, X468, X469, X470, X471, X472, X473, X474, X475, X476, X477, X478, X480 , X481, X482, X483, X484, X485, X486, X487, X488, X489, X490, X491, X492, X493, X494, X495, X496, X497, X498, X499, X500, X501, X502, X503, X504 , X506, X507, X508 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X463, X464 and / or X472, X473 and / or X485, X486 and / or X492, X493 and / or X501, X502 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX509, -NX510X511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X512, -C (O) O-X513, -C (O) NH-X514, -C (O) NX515X516, -O-X517, -O (-X518-O) _y -H (y = 1, 2, 3, 4, 5), -O (-X519-O) _y -X520 (y = 1, 2, 3, 4, 5), -OC (O) -X521, -OC (O) -O-X522, -OC (O) -NHX523, -O-C (O)- NX524X525, -OP (O) (OX526) (OX527), -OSi (X528) (X529) (X530), -OS (O ₂ ) -X531, -NHC (O) -X532, -NX533C (O) -X534, -NH-C (O) -O-X535, -NH-C (O) -NH-X536, -NH-C (O ) -NX537X538, -NX539-C (O) -O-X540, -NX541-C (O) -NH-X542, -NX543-C (O) -NX544X545, -NHS (O ₂ ) -X546, -NX547S (O ₂ ) -X548, -S-X549, -S (O) -X550, -S (O ₂ ) -X551, -S (O ₂ ) NH-X552, -S (O ₂ ) NX553X554, -S (O ₂ ) O-X555, -P (O) (OX556) (OX557), -Si (X558) (X559) (X560) ";
At that time, X509, X510, X511, X512, X513, X514, X515, X516, X517, X518, X519, X520, X521, X522, X523, X524, X525, X526, X527, X528, X529, X530, X531, X532 , X533, X534, X535, X536, X537, X538, X539, X540, X541, X542, X543, X544, X545, X546, X547, X548, X549, X550, X551, X552, X553, X554, X555, X556 , X558, X559, X560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X515, X516 and / or X524, X525 and / or X537, X538 and / or X544, X545 and / or X553, X554 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX561, -NX562X563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X564, -C (O) O-X565, -C (O) NH-X566, -C (O) NX567X568, -O-X569, -O (-X570-O) _z -H (z = 1, 2, 3, 4, 5), -O (-X571-O) _z -X572 (z = 1, 2, 3, 4, 5), -OC (O) -X573, -OC (O) -O-X574, -OC (O) -NHX575, -O-C (O)- NX576X577, -OP (O) (OX578) (OX579), -OSi (X580) (X581) (X582), -OS (O ₂ ) -X583, -NHC (O) -X584, -NX585C (O) -X586, -NH-C (O) -O-X587, -NH-C (O) -NH-X588, -NH-C (O ) -NX589X590, -NX591-C (O) -O-X592, -NX593-C (O) -NH-X594, -NX595-C (O) -NX596X597, -NHS (O ₂ ) -X598, -NX599S (O ₂ ) -X600, -S-X601, -S (O) -X602, -S (O ₂ ) -X603, -S (O ₂ ) NH-X604, -S (O ₂ ) NX605X606, -S (O ₂ ) O-X607, -P (O) (OX608) (OX609), -Si (X610) (X611) (X612) ";
At that time, X561, X562, X563, X564, X565, X566, X567, X568, X569, X570, X571, X572, X573, X574, X575, X576, X577, X578, X579, X580, X581, X582, X583, 584 X585, X586, X587, X588, X589, X590, X591, X592, X593, X594, X595, X596, X597, X598, X599, X600, X601, X602, X603, X604, X605, X606, X607, X608 , X610, X611, X612 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X567, X568 and / or X576, X577 and / or X589, X590 and / or X596, X597 and / or X605, X606 may each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX613, -NX614X615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X616, -C (O) O-X617, -C (O) NH-X618, -C (O) NX619X620, -O-X621, -O (-X622-O) _a -H (a = 1, 2, 3, 4, 5), -O (-X623-O) _a -X624 (a = 1, 2, 3, 4, 5), -OC (O) -X625, -OC (O) -O-X626, -OC (O) -NHX627, -O-C (O)- NX628X629, -OP (O) (OX630) (OX631), -OSi (X632) (X633) (X634), -OS (O ₂ ) -X635, -NHC (O) -X636, -NX637C (O) -X638, -NH-C (O) -O-X639, -NH-C (O) -NH-X640, -NH-C (O ) -NX641X642, -NX643-C (O) -O-X644, -NX645-C (O) -NH-X646, -NX647-C (O) -NX648X649, -NHS (O ₂ ) -X650, -NX651S (O ₂ ) -X652, -S-X653, -S (O) -X654, -S (O ₂ ) -X655, -S (O ₂ ) NH-X656, -S (O ₂ ) NX657X658, -S (O ₂ ) O-X659, -P (O) (OX660) (OX661), -Si (X662) (X663) (X664) ";
At that time, X613, X614, X615, X616, X617, X618, X619, X620, X621, X622, X623, X624, X625, X626, X627, X628, X629, X630, X631, X632, X633, X634, X635, X636 , X637, X638, X639, X640, X641, X642, X643, X644, X645, X646, X647, X648, X649, X650, X651, X652, X653, X654, X655, X656, X657, X658, X659, X660 , X662, X663, X664 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X619, X620 and / or X628, X629 and / or X641, X642 and / or X648, X649 and / or X657, X658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX665, -NX666X667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X668, -C (O) O-X669, -C (O) NH-X670, -C (O) NX671X672, -O-X673, -O (-X674-O) _b -H (b = 1, 2, 3, 4, 5), -O (-X675-O) _b -X676 (b = 1, 2, 3, 4, 5), -OC (O) -X677, -OC (O) -O-X678, -OC (O) -NHX679, -O-C (O)- NX680X681, -OP (O) (OX682) (OX683), -OSi (X684) (X685) (X686), -OS (O ₂ ) -X687, -NHC (O) -X688, -NX689C (O) -X690, -NH-C (O) -O-X691, -NH-C (O) -NH-X692, -NH-C (O ) -NX693X694, -NX695-C (O) -O-X696, -NX697-C (O) -NH-X698, -NX699-C (O) -NX700X701, -NHS (O ₂ ) -X702, -NX703S (O ₂ ) -X704, -S-X705, -S (O) -X706, -S (O ₂ ) -X707, -S (O ₂ ) NH-X708, -S (O ₂ ) NX709X710, -S (O ₂ ) O-X711, -P (O) (OX712) (OX713), -Si (X714) (X715) (X716) ";
At that time, X665, X666, X667, X668, X669, X670, X671, X672, X673, X674, X675, X676, X677, X678, X679, X680, X681, X682, X683, X684, X685, X686, X687, 688 X689, X690, X691, X692, X693, X694, X695, X696, X697, X698, X699, X700, X701, X702, X703, X704, X705, X706, X707, X708, X709, X710, X711, X712 , X714, X715, X716 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X671, X672 and / or X680, X681 and / or X693, X694 and / or X700, X701 and / or X709, X710 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX717, -NX718X719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X720, -C (O) O-X721, -C (O) NH-X722, -C (O) NX723X724, -O-X725, -O (-X726-O) _c -H (c = 1, 2, 3, 4, 5), -O (-X727-O) _c -X728 (c = 1, 2, 3, 4, 5), -OC (O) -X729, -OC (O) -O-X730, -OC (O) -NHX731, -O-C (O)- NX732X733, -OP (O) (OX734) (OX735), -OSi (X736) (X737) (X738), -OS (O ₂ ) -X739, -NHC (O) -X740, -NX741C (O) -X742, -NH-C (O) -O-X743, -NH-C (O) -NH-X744, -NH-C (O ) -NX745X746, -NX747-C (O) -O-X748, -NX749-C (O) -NH-X750, -NX751-C (O) -NX752X753, -NHS (O ₂ ) -X754, -NX755S (O ₂ ) -X756, -S-X757, -S (O) -X758, -S (O ₂ ) -X759, -S (O ₂ ) NH-X760, -S (O ₂ ) NX761X762, -S (O ₂ ) O-X763, -P (O) (OX764) (OX765), -Si (X766) (X767) (X768) ";
At that time, X717, X718, X719, X720, X721, X722, X723, X724, X725, X726, X727, X728, X729, X730, X731, X732, X733, X734, X735, X736, X737, X738, X739, X739 X741, X742, X743, X744, X745, X746, X747, X748, X749, X750, X751, X752, X753, X754, X755, X756, X757, X758, X759, X760, X761, X762, X763, 764 , X766, X767, X768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X723, X724 and / or X732, X733 and / or X745, X746 and / or X752, X753 and / or X761, X762 may each be taken together to form a "heterocyclyl";
(J) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX769, -NX770X771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X772, -C (O) O-X773, -C (O) NH-X774, -C (O) NX775X776, -O-X777, -O (-X778-O). _d -H (d = 1, 2, 3, 4, 5), -O (-X779-O) _d -X780 (d = 1, 2, 3, 4, 5), -OC (O) -X781, -OC (O) -O-X782, -OC (O) -NHX783, -O-C (O)- NX784X785, -OP (O) (OX786) (OX787), -OSi (X788) (X789) (X790), -OS (O ₂ ) -X791, -NHC (O) -X792, -NX793C (O) -X794, -NH-C (O) -O-X795, -NH-C (O) -NH-X796, -NH-C (O ) -NX797X798, -NX799-C (O) -O-X800, -NX801-C (O) -NH-X802, -NX803-C (O) -NX804X805, -NHS (O ₂ ) -X806, -NX807S (O ₂ ) -X808, -S-X809, -S (O) -X810, -S (O ₂ ) -X811, -S (O ₂ ) NH-X812, -S (O ₂ ) NX813X814, -S (O ₂ ) O-X815, -P (O) (OX816) (OX817), -Si (X818) (X819) (X820) ";
At that time, X769, X770, X771, X772, X773, X774, X775, X776, X777, X778, X779, X780, X781, X782, X783, X784, X785, X786, X787, X788, X789, X790, X791, 792 X793, X794, X795, X796, X797, X798, X799, X800, X801, X802, X803, X804, X805, X806, X807, X808, X809, X810, X811, X812, X813, X814, X815, X816 , X818, X819, X820 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X775, X776 and / or X784, X785 and / or X797, X798 and / or X804, X805 and / or X813, X814 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX821, -NX822X823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X824, -C (O) O-X825, -C (O) NH-X826, -C (O) NX827X828, -O-X829, -O (-X830-O) _e -H (e = 1, 2, 3, 4, 5), -O (-X831-O) _e -X832 (e = 1, 2, 3, 4, 5), -OC (O) -X833, -OC (O) -O-X834, -OC (O) -NHX835, -O-C (O)- NX836X837, -OP (O) (OX838) (OX839), -OSi (X840) (X841) (X842), -OS (O ₂ ) -X843, -NHC (O) -X844, -NX845C (O) -X846, -NH-C (O) -O-X847, -NH-C (O) -NH-X848, -NH-C (O ) -NX849X850, -NX851-C (O) -O-X852, -NX853-C (O) -NH-X854, -NX855-C (O) -NX856X857, -NHS (O ₂ ) -X858, -NX859S (O ₂ ) -X860, -S-X861, -S (O) -X862, -S (O ₂ ) -X863, -S (O ₂ ) NH-X864, -S (O ₂ ) NX865X866, -S (O ₂ ) O-X867, -P (O) (OX868) (OX869), -Si (X870) (X871) (X872) ";
At that time, X821, X822, X823, X824, X825, X826, X827, X828, X829, X830, X831, X832, X833, X834, X835, X836, X837, X838, X839, X840, X841, X842, X843, 44 X845, X846, X847, X848, X849, X850, X851, X852, X853, X854, X855, X856, X857, X858, X859, X860, X861, X862, X863, X864, X865, X866, X867, 86 , X870, X871, X872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X827, X828 and / or X836, X837 and / or X849, X850 and / or X856, X857 and / or X865, X866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX873, -NX874X875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X876, -C (O) O-X877, -C (O) NH-X878, -C (O) NX879X880, -O-X881, -O (-X882-O) _f -H (f = 1, 2, 3, 4, 5), -O (-X883-O) _f -X884 (f = 1, 2, 3, 4, 5), -OC (O) -X885, -OC (O) -O-X886, -OC (O) -NHX887, -O-C (O)- NX888X889, -OP (O) (OX890) (OX891), -OSi (X892) (X893) (X894), -OS (O ₂ ) -X895, -NHC (O) -X896, -NX897C (O) -X898, -NH-C (O) -O-X899, -NH-C (O) -NH-X900, -NH-C (O ) -NX901X902, -NX903-C (O) -O-X904, -NX905-C (O) -NH-X906, -NX907-C (O) -NX908X909, -NHS (O ₂ ) -X910, -NX911S (O ₂ ) -X912, -S-X913, -S (O) -X914, -S (O ₂ ) -X915, -S (O ₂ ) NH-X916, -S (O ₂ ) NX917X918, -S (O ₂ ) O-X919, -P (O) (OX920) (OX921), -Si (X922) (X923) (X924) ";
At that time, X873, X874, X875, X876, X877, X878, X879, X880, X881, X882, X883, X884, X885, X886, X887, X888, X889, X890, X891, X892, X893, X894, X895, 96 , X897, X898, X899, X900, X901, X902, X903, X904, X905, X906, X907, X908, X909, X910, X911, X912, X913, X914, X915, X916, X917, X918, X919, X920 , X922, X923, X924 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X879, X880 and / or X888, X889 and / or X901, X902 and / or X908, X909 and / or X917, X918 may each be taken together to form a “heterocyclyl”;
(K) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX925, -NX926X927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X928, -C (O) O-X929, -C (O) NH-X930, -C (O) NX931X932, -O-X933, -O (-X934-O) _g -H (g = 1, 2, 3, 4, 5), -O (-X935-O) _g -X936 (g = 1, 2, 3, 4, 5), -OC (O) -X937, -OC (O) -O-X938, -OC (O) -NHX939, -O-C (O)- NX940X941, -OP (O) (OX942) (OX943), -OSi (X944) (X945) (X946), -OS (O ₂ ) -X947, -NHC (O) -X948, -NX949C (O) -X950, -NH-C (O) -O-X951, -NH-C (O) -NH-X952, -NH-C (O ) -NX953X954, -NX955-C (O) -O-X956, -NX957-C (O) -NH-X958, -NX959-C (O) -NX960X961, -NHS (O ₂ ) -X962, -NX963S (O ₂ ) -X964, -S-X965, -S (O) -X966, -S (O ₂ ) -X967, -S (O ₂ ) NH-X968, -S (O ₂ ) NX969X970, -S (O ₂ ) O-X971, -P (O) (OX972) (OX973), -Si (X974) (X975) (X976) ";
At that time, X925, X926, X927, X928, X929, X930, X931, X932, X933, X934, X935, X936, X937, X938, X939, X940, X941, X942, X943, X944, X945, X946, X947, X948 , X949, X950, X951, X952, X953, X954, X955, X956, X957, X958, X959, X960, X961, X962, X963, X964, X965, X966, X967, X968, X969, X970, X971, X972 , X974, X975, X976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X931, X932 and / or X940, X941 and / or X953, X954 and / or X960, X961 and / or X969, X970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX977, -NX978X979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X980, -C (O) O-X981, -C (O) NH-X982, -C (O) NX983X984, -O-X985, -O (-X986-O) _h -H (h = 1, 2, 3, 4, 5), -O (-X987-O) _h -X988 (h = 1, 2, 3, 4, 5), -OC (O) -X989, -OC (O) -O-X990, -OC (O) -NHX991, -O-C (O)- NX992X993, -OP (O) (OX994) (OX995), -OSi (X996) (X997) (X998), -OS (O ₂ ) -X999, -NHC (O) -X1000, -NX1001C (O) -X1002, -NH-C (O) -O-X1003, -NH-C (O) -NH-X1004, -NH-C (O ) -NX1005X1006, -NX1007-C (O) -O-X1008, -NX1009-C (O) -NH-X1010, -NX1011-C (O) -NX1012X1013, -NHS (O ₂ ) -X1014, -NX1015S (O ₂ ) -X1016, -S-X1017, -S (O) -X1018, -S (O ₂ ) -X1019, -S (O ₂ ) NH-X1020, -S (O ₂ ) NX1021X1022, -S (O ₂ ) O-X1023, -P (O) (OX1024) (OX1025), -Si (X1026) (X1027) (X1028) ";
At that time, X977, X978, X979, X980, X981, X982, X983, X984, X985, X986, X987, X988, X989, X990, X991, X992, X993, X994, X995, X996, X997, X999, 1000 , X1001, X1002, X1003, X1004, X1005, X1006, X1007, X1008, X1009, X1010, X1011, X1012, X1013, X1014, X1015, X1016, X1017, X1018, X1019, X1020, X1021, X1022, X1023, X1024 , X1026, X1027, X1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X983, X984 and / or X992, X993 and / or X1005, X1006 and / or X1012, X1013 and / or X1021, X1022 may each be taken together to form a "heterocyclyl";
(L) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1029, -NX1030X1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1032, -C (O) O-X1033, -C (O) NH-X1034, -C (O) NX1035X1036, -O-X1037, -O (-X1038-O) _i -H (i = 1, 2, 3, 4, 5), -O (-X1039-O) _i -X1040 (i = 1, 2, 3, 4, 5), -OC (O) -X1041, -OC (O) -O-X1042, -OC (O) -NHX1043, -O-C (O)- NX1044X1045, -OP (O) (OX1046) (OX1047), -OSi (X1048) (X1049) (X1050), -OS (O ₂ ) -X1051, -NHC (O) -X1052, -NX1053C (O) -X1054, -NH-C (O) -O-X1055, -NH-C (O) -NH-X1056, -NH-C (O ) -NX1057X1058, -NX1059-C (O) -O-X1060, -NX1061-C (O) -NH-X1062, -NX1063-C (O) -NX1064X1065, -NHS (O ₂ ) -X1066, -NX1067S (O ₂ ) -X1068, -S-X1069, -S (O) -X1070, -S (O ₂ ) -X1071, -S (O ₂ ) NH-X1072, -S (O ₂ ) NX1073X1074, -S (O ₂ ) O-X1075, -P (O) (OX1076) (OX1077), -Si (X1078) (X1079) (X1080) ";
At that time, X1029, X1030, X1031, X1032, X1033, X1034, X1035, X1036, X1037, X1038, X1039, X1040, X1041, X1042, X1043, X1044, X1045, X1046, X1047, X1048, X1049, X1050, X1051, X1050 X1053, X1054, X1055, X1056, X1057, X1058, X1059, X1060, X1061, X1062, X1063, X1064, X1065, X1066, X1067, X1068, X1069, X1070, X1071, X1072, X1073, X1074, X1075, X1076 , X1078, X1079, X1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1035, X1036 and / or X1044, X1045 and / or X1057, X1058 and / or X1064, X1065 and / or X1073, X1074 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1081, -NX1082X1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1084, -C (O) O-X1085, -C (O) NH-X1086, -C (O) NX1087X1088, -O-X1089, -O (-X1090-O) _j -H (j = 1, 2, 3, 4, 5), -O (-X1091-O) _j -X1092 (j = 1, 2, 3, 4, 5), -OC (O) -X1093, -OC (O) -O-X1094, -OC (O) -NHX1095, -O-C (O)- NX1096X1097, -OP (O) (OX1098) (OX1099), -OSi (X1100) (X1101) (X1102), -OS (O ₂ ) -X1103, -NHC (O) -X1104, -NX1105C (O) -X1106, -NH-C (O) -O-X1107, -NH-C (O) -NH-X1108, -NH-C (O ) -NX1109X1110, -NX1111-C (O) -O-X1112, -NX1113-C (O) -NH-X1114, -NX1115-C (O) -NX1116X1117, -NHS (O ₂ ) -X1118, -NX1119S (O ₂ ) -X1120, -S-X1121, -S (O) -X1122, -S (O ₂ ) -X1123, -S (O ₂ ) NH-X1124, -S (O ₂ ) NX1125X1126, -S (O ₂ ) O-X1127, -P (O) (OX1128) (OX1129), -Si (X1130) (X1131) (X1132) ";
At that time, X1081, X1082, X1083, X1084, X1085, X1086, X1087, X1088, X1089, X1090, X1091, X1092, X1093, X1094, X1095, X1096, X1097, X1098, X1099, X1100, X1101, X1102, X1103, X1104 X1105, X1106, X1107, X1108, X1109, X1110, X1111, X1112, X1113, X1114, X1115, X1116, X1117, X1118, X1119, X1120, X1121, X1122, X1123, X1124, X1125, X1126, X1127, X1128 , X1130, X1131, and X1132, independently of one another, represent “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1087, X1088 and / or X1096, X1097 and / or X1109, X1110 and / or X1116, X1117 and / or X1125, X1126 may each be taken together to form a "heterocyclyl";
(M) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -X1133, -C (O) O-X1134, -C (O)- NX1135X1136, -S (O ₂ ) -X1137, -S (O ₂ ) O-X1138 ";
In this case, X1133, X1134, X1135, X1136, X1137, and X1138 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, X1135, X1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1139, -NX1140X1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1142, -C (O) O-X1143, -C (O) NH-X1144, -C (O) NX1145X1146, -O-X1147, -O (-X1148-O) _k -H (k = 1, 2, 3, 4, 5), -O (-X1149-O) _k -X1150 (k = 1, 2, 3, 4, 5), -OC (O) -X1151, -OC (O) -O-X1152, -OC (O) -NHX1153, -O-C (O)- NX1154X1155, -OP (O) (OX1156) (OX1157), -OSi (X1158) (X1159) (X1160), -OS (O ₂ ) -X1161, -NHC (O) -X1162, -NX1163C (O) -X1164, -NH-C (O) -O-X1165, -NH-C (O) -NH-X1166, -NH-C (O ) -NX1167X1168, -NX1169-C (O) -O-X1170, -NX1171-C (O) -NH-X1172, -NX1173-C (O) -NX1174X1175, -NHS (O ₂ ) -X1176, -NX1177S (O ₂ ) -X1178, -S-X1179, -S (O) -X1180, -S (O ₂ ) -X1181, -S (O ₂ ) NH-X1182, -S (O ₂ ) NX1183X1184, -S (O ₂ ) O-X1185, -P (O) (OX1186) (OX1187), -Si (X1188) (X1189) (X1190) ";
At that time, X1139, X1140, X1141, X1142, X1143, X1144, X1145, X1146, X1147, X1148, X1149, X1150, X1151, X1152, X1153, X1154, X1155, X1156, X1157, X1158, X1159, X1160, X1161, X2160 X1163, X1164, X1165, X1166, X1167, X1168, X1169, X1170, X1171, X1172, X1173, X1174, X1175, X1176, X1177, X1178, X1179, X1180, X1181, X1182, X1183, X1186, X1185, X1186, X1185, X1186 , X1188, X1189, X1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1145, X1146 and / or X1154, X1155 and / or X 1167, X 1168 and / or X 1174, X 1175 and / or X 1183, X 1184 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1191, -NX1192X1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1194, -C (O) O-X1195, -C (O) NH-X1196, -C (O) NX1197X1198, -O-X1199, -O (-X1200-O) _l -H (l = 1, 2, 3, 4, 5), -O (-X1201-O) _l -X1202 (l = 1, 2, 3, 4, 5), -OC (O) -X1203, -OC (O) -O-X1204, -OC (O) -NHX1205, -O-C (O)- NX1206X1207, -OP (O) (OX1208) (OX1209), -OSi (X1210) (X1211) (X1212), -OS (O ₂ ) -X1213, -NHC (O) -X1214, -NX1215C (O) -X1216, -NH-C (O) -O-X1217, -NH-C (O) -NH-X1218, -NH-C (O ) -NX1219X1220, -NX1221-C (O) -O-X1222, -NX1223-C (O) -NH-X1224, -NX1225-C (O) -NX1226X1227, -NHS (O ₂ ) -X1228, -NX1229S (O ₂ ) -X1230, -S-X1231, -S (O) -X1232, -S (O ₂ ) -X1233, -S (O ₂ ) NH-X1234, -S (O ₂ ) NX1235X1236, -S (O ₂ ) O-X1237, -P (O) (OX1238) (OX1239), -Si (X1240) (X1241) (X1242) ";
In that case, X1191, X1192, X1193, X1194, X1195, X1196, X1197, X1198, X1199, X1200, X1201, X1202, X1203, X1204, X1205, X1206, X1207, X1208, X1209, X1210, X1211, X1212, X1213, X1213 , X1215, X1216, X1217, X1218, X1219, X1220, X1221, X1222, X1223, X1224, X1225, X1226, X1227, X1228, X1229, X1230, X1231, X1232, X1233, X1234, X1235, X1236, X1237, 3938 , X1240, X1241, and X1242 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1197, X1198 and / or X1206, X1207 and / or X1219, X1220 and / or X1226, X1227 and / or X1235, X1236 can each be taken together to form a “heterocyclyl”;
Or
(B)
One or both radicals Z3, Z4 of the radicals Z3, Z4, independently of one another, are “substituted heteroaryl”, wherein “substituted heteroaryl” is selected from the group consisting of Substituted with at least one substituent:
(A) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-V1, -N (alkyl) ₂ , —NHC (O) -alkyl, —NHC (O) -cycloalkyl, —NHC (O) -heterocyclyl, —NHC (O) -aryl, —NHC (O) -heteroaryl, —NHC (O) -aryl Alkyl, -NHC (O) -heteroarylalkyl, -NHS (O ₂ ) -Alkyl, -NHS (O ₂ ) -Cycloalkyl, -NHS (O ₂ ) -Heterocyclyl, -NHS (O ₂ ) -Aryl, -NHS (O ₂ ) -Heteroaryl, -NHS (O ₂ ) -Arylalkyl, -NHS (O ₂ ) -Heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -O-alkyl, -O-cycloalkyl, -O-cycloalkylalkyl, -O-aryl, -O-arylalkyl , -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclylalkyl, -OC (O) -alkyl, -OC (O) -cycloalkyl, -OC (O) -heterocyclyl, -OC (O) -Aryl, -OC (O) -heteroaryl, -OC (O) -arylalkyl, -OC (O) -heteroarylalkyl, -OS (O ₂ ) -Alkyl, -OS (O ₂ ) -Cycloalkyl, -OS (O ₂ ) -Heterocyclyl, -OS (O ₂ ) -Aryl, -OS (O ₂ ) -Heteroaryl, -OS (O ₂ ) -Arylalkyl, -OS (O ₂ ) -Heteroarylalkyl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl, -C (O) O-V2, -C (O) NH-V3,- C (O) N (alkyl) ₂ , -C (O) N (cycloalkyl) ₂ , -C (O) N (aryl) ₂ , -C (O) N (heteroaryl) ₂ , -S (O ₂ ) NH-alkyl, -S (O ₂ ) NH-aryl, -S (O ₂ ) NH-heteroaryl, -S (O ₂ ) NH-arylalkyl, S (O ₂ ) O-alkyl, -S (O ₂ ) O-aryl, -S (O ₂ ) O-arylalkyl ";
Wherein V1, V2, V3 are independently selected from the group consisting of “alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl”;
However, the above substituents of the substituent group (a) are further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N _Three , -NH-cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NV4V5, -S- Cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -O-cycloalkyl , -O-cycloalkylalkyl, -O-arylalkyl, -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclyl, -O-heterocyclylalkyl, -O (-V6-O) _p -H (p = 1, 2, 3, 4, 5), -O (-V7-O) _p -V8 (p = 1, 2, 3, 4, 5), -OP (O) (OV9) (OV10), -C (O) O-V11, -C (O) NH ₂ , -C (O) NH-V12, -C (O) NV13V14, -S (O ₂ ) -V15, -P (O) (OH) ₂ , -P (O) (OV16) (OV17), -Si (V18) (V19) (V20), -O-Si (V21) (V22) (V23), -O-C (O) -O-V24 , -O-C (O) -NH-V25, -O-C (O) -NV26V27, -NH-C (O) -O-V28, -NH-C (O) -NH-V29, -NH- C (O) -NV30V31, -NV32-C (O) -O-V33, -NV34-C (O) -NH-V35, -NV36-C (O) -NV37V38, -NV39-S (O ₂ ) -V40, -NH-S (O ₂ ) -V41, -O-S (O ₂ ) -V42, -NH-C (O) -V43, -NV44-C (O) -V45, -C (O) -V46, -OC (O) -V47, -S (O) -V48, -S (O ₂ ) -NHV49, -S (O ₂ ) -NV50V51, -S (O ₂ ) -OV52 ";
However, in addition, “—N (alkyl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (b);
At that time, V4, V5, V6, V7, V8, V9, V10, V11, V12, V13, V14, V15, V16, V17, V18, V19, V20, V21, V22, V23, V24, V25, V26, V27 , V28, V29, V30, V31, V32, V33, V34, V35, V36, V37, V38, V39, V40, V41, V42, V43, V44, V45, V46, V47, V48, V49, V50, V51, V52 Are independent of each other, "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, V13, V14 and / or V26, V27 and / or Or V30, V31 and / or V37, V38 and / or V50, V51 may be taken together to form a "heterocyclyl";
In that case, optionally additionally, one of the groups Z3, Z4, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(B) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV53, -NV54V55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V56, -C (O) O-V57, -C (O) NH-V58, -C (O) NV59V60, -O-V61, -O (-V62-O) _r -H (r = 1, 2, 3, 4, 5), -O (-V63-O) _r -V64 (r = 1, 2, 3, 4, 5), -OC (O) -V65, -OC (O) -O-V66, -OC (O) -NHV67, -O-C (O)- NV68V69, -OP (O) (OV70) (OV71), -OSi (V72) (V73) (V74), -OS (O ₂ ) -V75, -NHC (O) -V76, -NV77C (O) -V78, -NH-C (O) -O-V79, -NH-C (O) -NH-V80, -NH-C (O ) -NV81V82, -NV83-C (O) -O-V84, -NV85-C (O) -NH-V86, -NV87-C (O) -NV88V89, -NHS (O ₂ ) -V90, -NV91S (O ₂ ) -V92, -S-V93, -S (O) -V94, -S (O ₂ ) -V95, -S (O ₂ ) NH-V96, -S (O ₂ ) NV97V98, -S (O ₂ ) O-V99, -P (O) (OV100) (OV101), -Si (V102) (V103) (V104) ";
At that time, V53, V54, V55, V56, V57, V58, V59, V60, V61, V62, V63, V64, V65, V66, V67, V68, V69, V70, V71, V72, V73, V74, V75, V76 , V77, V78, V79, V80, V81, V82, V83, V84, V85, V86, V87, V88, V89, V90, V91, V92, V93, V94, V95, V96, V97, V98, V99, V100, V101 , V102, V103, V104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V59, V60 and / or V68, V69 and / or V81, V82 and / or V88, V89 and / or V97, V98 can be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (b) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV105, -NV106V107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V108, -C (O) O-V109, -C (O) NH-V110, -C (O) NV111V112, -O-V113, -O (-V114-O) _s -H (s = 1, 2, 3, 4, 5), -O (-V115-O) _s -V116 (s = 1, 2, 3, 4, 5), -OC (O) -V117, -OC (O) -O-V118, -OC (O) -NHV119, -O-C (O)- NV120V121, -OP (O) (OV122) (OV123), -OSi (V124) (V125) (V126), -OS (O ₂ ) -V127, -NHC (O) -V128, -NV129C (O) -V130, -NH-C (O) -O-V131, -NH-C (O) -NH-V132, -NH-C (O ) -NV133V134, -NV135-C (O) -O-V136, -NV137-C (O) -NH-V138, -NV139-C (O) -NV140V141, -NHS (O ₂ ) -V142, -NV143S (O ₂ ) -V144, -S-V145, -S (O) -V146, -S (O ₂ ) -V147, -S (O ₂ ) NH-V148, -S (O ₂ ) NV149V150, -S (O ₂ ) O-V151, -P (O) (OV152) (OV153), -Si (V154) (V155) (V156) ";
At that time, V105, V106, V107, V108, V109, V110, V111, V112, V113, V114, V115, V116, V117, V118, V119, V120, V121, V122, V123, V124, V125, V126, V127, V128 , V129, V130, V131, V132, V133, V134, V135, V136, V137, V138, V139, V140, V141, V142, V143, V144, V145, V146, V147, V148, V149, V150, V151, V152, V153 , V154, V155, V156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V111, V112 and / or V120, V121 and / or V133, V134 and / or V140, V141 and / or V149, V150 may be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV157, -NV158V159, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V160, -C (O) O-V161, -C (O) NH-V162, -C (O) NV163V164, -O-V165, -O (-V166-O) _t -H (t = 1, 2, 3, 4, 5), -O (-V167-O) _t -V168 (t = 1, 2, 3, 4, 5), -OC (O) -V169, -OC (O) -O-V170, -OC (O) -NHV171, -O-C (O)- NV172V173, -OP (O) (OV174) (OV175), -OSi (V176) (V177) (V178), -OS (O ₂ ) -V179, -NHC (O) -V180, -NV181C (O) -V182, -NH-C (O) -O-V183, -NH-C (O) -NH-V184, -NH-C (O ) -NV185V186, -NV187-C (O) -O-V188, -NV189-C (O) -NH-V190, -NV191-C (O) -NV192V193, -NHS (O ₂ ) -V194, -NV195S (O ₂ ) -V196, -S-V197, -S (O) -V198, -S (O ₂ ) -V199, -S (O ₂ ) NH-V200, -S (O ₂ ) NV201V202, -S (O ₂ ) O-V203, -P (O) (OV204) (OV205), -Si (V206) (V207) (V208) ";
At that time, V157, V158, V159, V160, V161, V162, V163, V164, V165, V166, V167, V168, V169, V170, V171, V172, V173, V174, V175, V176, V177, V178, V179, V180 , V181, V182, V183, V184, V185, V186, V187, V188, V189, V190, V191, V192, V193, V194, V195, V196, V197, V198, V199, V200, V201, V202, V203, V204, V205 , V206, V207, V208 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V163, V164 and / or V172, V173 and / or V185, V186 and / or V192, V193 and / or V201, V202 may be taken together to form a "heterocyclyl";
Or
One or both radicals Z3, Z4 of the radicals Z3, Z4 are, independently of one another, "substituted heteroaryl", wherein "substituted heteroaryl" consists of the following: Substituted by at least one substituent selected from the group:
(C) "C ₉ ~ C ₃₀ -Alkyl, -NV209V210, -NH-C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -cycloalkylalkyl, -NHC (O) -heterocyclylalkyl, -NHC (O) -C ₉ ~ C ₃₀ -Alkyl, -NV211C (O) -V212, -NV213C (O) -C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -OV214, -NV215C (O) -OV216, -NHC (O) -NHV217, -NHC (O) -NV218V219, -NV220C (O) -NHV221, -NV222C (O) -NV223V224 , -NHS (O ₂ ) -Cycloalkylalkyl, -NHS (O ₂ ) -Heterocyclylalkyl, -NV225S (O ₂ ) -V226, -O-heterocyclyl, -O-C ₉ ~ C ₃₀ -Alkyl, -S-cycloalkyl, -S-heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S-cycloalkylalkyl, -S-heterocyclylalkyl, -S-C ₉ ~ C ₃₀ -Alkyl, -OC (O) -cycloalkylalkyl, -OC (O) -heterocyclylalkyl, -OC (O) -C ₉ ~ C ₃₀ -Alkyl, -OC (O) -OV227, -OC (O) -NHV228, -OC (O) -NV229V230, -OP (O) (OV231) (OV232), -OS (O ₂ ) -Cycloalkylalkyl, -OS (O ₂ ) -Heterocyclylalkyl, -OS (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -heterocyclyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -C (O) -cycloalkylalkyl,- C (O) -heterocyclylalkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) O-C ₉ ~ C ₃₀ -Alkyl, -C (O) NH-C ₉ ~ C ₃₀ -Alkyl, -C (O) NV233V234, -C (O) NH-OV235, -C (O) NV236-OV237, -C (O) NH-NV238V239, -C (O) NV240-NV241V242, -S (O ) -V243, -S (O ₂ ) -V244, -S (O ₂ ) NH-cycloalkyl, -S (O ₂ ) NH-heterocyclyl, -S (O ₂ ) NH-heteroarylalkyl, -S (O ₂ ) NH-cycloalkylalkyl, -S (O ₂ ) NH-heterocyclylalkyl, -S (O ₂ ) NH-C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) O-cycloalkyl, -S (O ₂ ) O-heterocyclyl, -S (O ₂ ) O-heteroaryl, -S (O ₂ ) O-heteroarylalkyl, -S (O ₂ ) O-cycloalkylalkyl, -S (O ₂ ) O-heterocyclylalkyl, -S (O ₂ ) O-C ₉ ~ C ₃₀ -Alkyl, -P (O) (OH) ₂ , -P (O) (OV245) (OV246), -Si (V247) (V248) (V247), -O-Si (V250) (V251) (V252) ";
At that time, V209, V210, V211, V212, V213, V214, V215, V216, V217, V218, V219, V220, V221, V222, V223, V224, V225, V226, V227, V228, V229, V230, V231, V232 , V233, V234, V235, V236, V237, V238, V239, V240, V241, V242, V243, V244, V245, V246, V247, V248, V249, V249, V250, V251, V252 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from V218, V219 and / or V223, V224 and / or Or V229, V230 and / or V233, V234 and / or V238, V239 and / or V241, V242 may each be taken together to form a "heterocyclyl";
Provided that the substituent "-N (alkyl) ₂ ","-C (O) N (alkyl) ₂ ","-C (O) N (cycloalkyl) ₂ ","-C (O) N (aryl) ₂ ","-C (O) N (heteroaryl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (i);
In this case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV253, -NV254V255, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V256, -C (O) O-V257, -C (O) NH-V258, -C (O) NV259V260, -O-V261, -O (-V262-O) _u -H (u = 1, 2, 3, 4, 5), -O (-V263-O) _u -V264 (u = 1, 2, 3, 4, 5), -OC (O) -V265, -OC (O) -O-V266, -OC (O) -NHV267, -O-C (O)- NV268V269, -OP (O) (OV270) (OV271), -OSi (V272) (V273) (V274), -OS (O ₂ ) -V275, -NHC (O) -V276, -NV277C (O) -V278, -NH-C (O) -O-V279, -NH-C (O) -NH-V280, -NH-C (O ) -NV281V282, -NV283-C (O) -O-V284, -NV285-C (O) -NH-V286, -NV287-C (O) -NV288V289, -NHS (O ₂ ) -V290, -NV291S (O ₂ ) -V292, -S-V293, -S (O) -V294, -S (O ₂ ) -V295, -S (O ₂ ) NH-V296, -S (O ₂ ) NV297V298, -S (O ₂ ) O-V299, -P (O) (OV300) (OV301), -Si (V302) (V303) (V304) ";
At that time, V253, V254, V255, V256, V257, V258, V259, V260, V261, V262, V263, V264, V265, V266, V267, V268, V269, V270, V271, V272, V273, V274, V275, V276 V277, V278, V279, V280, V281, V282, V283, V284, V285, V286, V287, V288, V289, V290, V291, V292, V293, V294, V295, V296, V297, V298, V299, V300, V299 , V302, V303, V304 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V259, V260 and / or V268, V269 and / or V281, V282 and / or V288, V289 and / or V297, V298 may be taken together to form a “heterocyclyl”;
In that case, optionally, one of the groups Z3, Z3, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(D) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV305, -NV306V307, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V308, -C (O) O-V309, -C (O) NH-V310, -C (O) NV311V312, -O-V313, -O (-V314-O) _v -H (v = 1, 2, 3, 4, 5), -O (-V315-O) _v -V316 (v = 1, 2, 3, 4, 5), -OC (O) -V317, -OC (O) -O-V318, -OC (O) -NHV319, -O-C (O)- NV320V321, -OP (O) (OV322) (OV323), -OSi (V324) (V325) (V326), -OS (O ₂ ) -V327, -NHC (O) -V328, -NV329C (O) -V330, -NH-C (O) -O-V331, -NH-C (O) -NH-V332, -NH-C (O ) -NV333V334, -NV335-C (O) -O-V336, -NV337-C (O) -NH-V338, -NV339-C (O) -NV340V341, -NHS (O ₂ ) -V342, -NV343S (O ₂ ) -V344, -S-V345, -S (O) -V346, -S (O ₂ ) -V347, -S (O ₂ ) NH-V348, -S (O ₂ ) NV349V350, -S (O ₂ ) O-V351, -P (O) (OV352) (OV353), -Si (V354) (V355) (V356) ";
At that time, V305, V306, V307, V308, V309, V310, V311, V312, V313, V314, V315, V316, V317, V318, V319, V320, V321, V322, V323, V324, V325, V326, V327, V328 , V329, V330, V331, V332, V333, V334, V335, V336, V337, V338, V339, V340, V341, V342, V343, V344, V345, V346, V347, V348, V349, V350, V351, V352, 353 , V354, V355, V356 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V311, V312 and / or V320, V321 and / or V333, V334 and / or V340, V341 and / or V349, V350 may be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (d) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV357, -NV358V359, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V360, -C (O) O-V361, -C (O) NH-V362, -C (O) NV363V364, -O-V365, -O (-V366-O) _w -H (w = 1, 2, 3, 4, 5), -O (-V367-O) _w -V368 (w = 1, 2, 3, 4, 5), -OC (O) -V369, -OC (O) -O-V370, -OC (O) -NHV371, -O-C (O)- NV372V373, -OP (O) (OV374) (OV375), -OSi (V376) (V377) (V378), -OS (O ₂ ) -V379, -NHC (O) -V380, -NV381C (O) -V382, -NH-C (O) -O-V383, -NH-C (O) -NH-V384, -NH-C (O ) -NV385V386, -NV387-C (O) -O-V388, -NV389-C (O) -NH-V390, -NV391-C (O) -NV392V393, -NHS (O ₂ ) -V394, -NV395S (O ₂ ) -V396, -S-V397, -S (O) -V398, -S (O ₂ ) -V399, -S (O ₂ ) NH-V400, -S (O ₂ ) NV401V402, -S (O ₂ ) O-V403, -P (O) (OV404) (OV405), -Si (V406) (V407) (V408) ";
At that time, V357, V358, V359, V360, V361, V362, V363, V364, V365, V366, V367, V368, V369, V370, V371, V372, V373, V374, V375, V376, V377, V378, V379, V379 , V381, V382, V383, V384, V385, V386, V387, V388, V389, V390, V391, V392, V393, V394, V395, V396, V397, V398, V399, V400, V401, V402, V403, V404, V405 , V406, V407, V408 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V363, V364 and / or V372, V373 and / or V385, V386 and / or V392, V393 and / or V401, V402 may be taken together to form a "heterocyclyl";
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV409, -NV410V411, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V412, -C (O) O-V413, -C (O) NH-V414, -C (O) NV415V416, -O-V417, -O (-V418-O) _x -H (x = 1, 2, 3, 4, 5), -O (-V419-O) _x -V420 (x = 1, 2, 3, 4, 5), -OC (O) -V421, -OC (O) -O-V422, -OC (O) -NHV423, -O-C (O)- NV424V425, -OP (O) (OV426) (OV427), -OSi (V428) (V429) (V430), -OS (O ₂ ) -V431, -NHC (O) -V432, -NV433C (O) -V434, -NH-C (O) -O-V435, -NH-C (O) -NH-V436, -NH-C (O ) -NV437V438, -NV439-C (O) -O-V440, -NV441-C (O) -NH-V442, -NV443-C (O) -NV444V445, -NHS (O ₂ ) -V446, -NV447S (O ₂ ) -V448, -S-V449, -S (O) -V450, -S (O ₂ ) -V451, -S (O ₂ ) NH-V452, -S (O ₂ ) NV453V454, -S (O ₂ ) O-V455, -P (O) (OV456a) (OV456b), -Si (V456c) (V456d) (V456e) ";
At that time, V409, V410, V411, V412, V413, V414, V415, V416, V417, V418, V419, V420, V421, V422, V423, V424, V425, V426, V427, V428, V429, V430, V431, V432 , V433, V434, V435, V436, V437, V438, V439, V440, V441, V442, V443, V444, V445, V446, V447, V448, V449, V450, V451, V452, V453, V454, V455, V456b , V456c, V456d, and V456e are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V415, V416 and / or V424, V425 and / or V437, V438 and / or V444, V445 and / or V453, V454 may be taken together to form a “heterocyclyl”;
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(E) hydrogen;
(F) halogen, F, Cl, Br, I;
(G) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV457, -NV458V459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V460, -C (O) O-V461, -C (O) NH-V462, -C (O) NV463V464, -O-V465, -O (-V466-O) _y -H (y = 1, 2, 3, 4, 5), -O (-V467-O) _y -V468 (y = 1, 2, 3, 4, 5), -OC (O) -V469, -OC (O) -O-V470, -OC (O) -NHV471, -O-C (O)- NV472V473, -OP (O) (OV474) (OV475), -OSi (V476) (V477) (V478), -OS (O ₂ ) -V479, -NHC (O) -V480, -NV481C (O) -V482, -NH-C (O) -O-V483, -NH-C (O) -NH-V484, -NH-C (O ) -NV485V486, -NV487-C (O) -O-V488, -NV489-C (O) -NH-V490, -NV491-C (O) -NV492V493, -NHS (O ₂ ) -V494, -NV495S (O ₂ ) -V496, -S-V497, -S (O) -V498, -S (O ₂ ) -V499, -S (O ₂ ) NH-V500, -S (O ₂ ) NV501V502, -S (O ₂ ) O-V503, -P (O) (OV504) (OV505), -Si (V506) (V507) (V508) ";
At that time, V457, V458, V459, V460, V461, V462, V463, V464, V465, V466, V467, V468, V469, V470, V471, V472, V473, V474, V475, V476, V477, V478, V480, V479 , V481, V482, V483, V484, V485, V486, V487, V488, V489, V490, V491, V492, V493, V494, V495, V496, V497, V498, V499, V500, V501, V502, V503, V504, V504 , V506, V507, V508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V463, V464 and / or V472, V473 and / or V485, V486 and / or V492, V493 and / or V501, V502 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV509, -NV510V511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V512, -C (O) O-V513, -C (O) NH-V514, -C (O) NV515V516, -O-V517, -O (-V518-O) _z -H (z = 1, 2, 3, 4, 5), -O (-V519-O) _z -V520 (z = 1, 2, 3, 4, 5), -OC (O) -V521, -OC (O) -O-V522, -OC (O) -NHV523, -O-C (O)- NV524V525, -OP (O) (OV526) (OV527), -OSi (V528) (V529) (V530), -OS (O ₂ ) -V531, -NHC (O) -V532, -NV533C (O) -V534, -NH-C (O) -O-V535, -NH-C (O) -NH-V536, -NH-C (O ) -NV537V538, -NV539-C (O) -O-V540, -NV541-C (O) -NH-V542, -NV543-C (O) -NV544V545, -NHS (O ₂ ) -V546, -NV547S (O ₂ ) -V548, -S-V549, -S (O) -V550, -S (O ₂ ) -V551, -S (O ₂ ) NH-V552, -S (O ₂ ) NV553V554, -S (O ₂ ) O-V555, -P (O) (OV556) (OV557), -Si (V558) (V559) (V560) ";
At that time, V509, V510, V511, V512, V513, V514, V515, V516, V517, V518, V519, V520, V521, V522, V523, V524, V525, V526, V527, V528, V529, V530, V531, V532 , V533, V534, V535, V536, V537, V538, V539, V540, V541, V542, V543, V544, V545, V546, V547, V548, V549, V550, V551, V552, V553, V554, V555, V556 , V558, V559, V560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V515, V516 and / or V524, V525 and / or V537, V538 and / or V544, V545 and / or V553, V554 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV561, -NV562V563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V564, -C (O) O-V565, -C (O) NH-V566, -C (O) NV567V568, -O-V569, -O (-V570-O) _a -H (a = 1, 2, 3, 4, 5), -O (-V571-O) _a -V572 (a = 1, 2, 3, 4, 5), -OC (O) -V573, -OC (O) -O-V574, -OC (O) -NHV575, -O-C (O)- NV576V577, -OP (O) (OV578) (OV579), -OSi (V580) (V581) (V582), -OS (O ₂ ) -V583, -NHC (O) -V584, -NV585C (O) -V586, -NH-C (O) -O-V587, -NH-C (O) -NH-V588, -NH-C (O ) -NV589V590, -NV591-C (O) -O-V592, -NV593-C (O) -NH-V594, -NV595-C (O) -NV596V597, -NHS (O ₂ ) -V598, -NV599S (O ₂ ) -V600, -S-V601, -S (O) -V602, -S (O ₂ ) -V603, -S (O ₂ ) NH-V604, -S (O ₂ ) NV605V606, -S (O ₂ ) O-V607, -P (O) (OV608) (OV609), -Si (V610) (V611) (V612) ";
At that time, V561, V562, V563, V564, V565, V566, V567, V568, V569, V570, V571, V572, V573, V574, V575, V576, V577, V578, V579, V580, V581, V582, V58 , V585, V586, V587, V588, V589, V590, V591, V592, V593, V594, V595, V596, V597, V598, V599, V600, V601, V602, V603, V604, V605, V606, V607, V608, V607 , V610, V611, V612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V567, V568 and / or V576, V577 and / or V589, V590 and / or V596, V597 and / or V605, V606 may each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV613, -NV614V615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V616, -C (O) O-V617, -C (O) NH-V618, -C (O) NV619V620, -O-V621, -O (-V622-O) _b -H (b = 1, 2, 3, 4, 5), -O (-V623-O) _b -V624 (b = 1, 2, 3, 4, 5), -OC (O) -V625, -OC (O) -O-V626, -OC (O) -NHV627, -O-C (O)- NV628V629, -OP (O) (OV630) (OV631), -OSi (V632) (V633) (V634), -OS (O ₂ ) -V635, -NHC (O) -V636, -NV637C (O) -V638, -NH-C (O) -O-V639, -NH-C (O) -NH-V640, -NH-C (O ) -NV641V642, -NV643-C (O) -O-V644, -NV645-C (O) -NH-V646, -NV647-C (O) -NV648V649, -NHS (O ₂ ) -V650, -NV651S (O ₂ ) -V652, -S-V653, -S (O) -V654, -S (O ₂ ) -V655, -S (O ₂ ) NH-V656, -S (O ₂ ) NV657V658, -S (O ₂ ) O-V659, -P (O) (OV660) (OV661), -Si (V662) (V663) (V664) ";
At that time, V613, V614, V615, V616, V617, V618, V619, V620, V621, V622, V623, V624, V625, V626, V627, V628, V629, V630, V631, V632, V633, V634, V635, V636 , V637, V638, V639, V640, V641, V642, V643, V644, V645, V646, V647, V648, V649, V650, V651, V652, V653, V654, V655, V656, V657, V658, V659, V660, V659, V660 , V662, V663, V664 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V619, V620 and / or V628, V629 and / or V641, V642 and / or V648, V649 and / or V657, V658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV665, -NV666V667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V668, -C (O) O-V669, -C (O) NH-V670, -C (O) NV671V672, -O-V673, -O (-V674-O) _c -H (c = 1, 2, 3, 4, 5), -O (-V675-O) _c -V676 (c = 1, 2, 3, 4, 5), -OC (O) -V677, -OC (O) -O-V678, -OC (O) -NHV679, -O-C (O)- NV680V681, -OP (O) (OV682) (OV683), -OSi (V684) (V685) (V686), -OS (O ₂ ) -V687, -NHC (O) -V688, -NV689C (O) -V690, -NH-C (O) -O-V691, -NH-C (O) -NH-V692, -NH-C (O ) -NV693V694, -NV695-C (O) -O-V696, -NV697-C (O) -NH-V698, -NV699-C (O) -NV700V701, -NHS (O ₂ ) -V702, -NV703S (O ₂ ) -V704, -S-V705, -S (O) -V706, -S (O ₂ ) -V707, -S (O ₂ ) NH-V708, -S (O ₂ ) NV709V710, -S (O ₂ ) O-V711, -P (O) (OV712) (OV713), -Si (V714) (V715) (V716) ";
At that time, V665, V666, V667, V668, V669, V670, V671, V672, V673, V674, V675, V676, V677, V678, V679, V680, V681, V682, V683, V684, V685, V686, V687, V687 , V689, V690, V691, V692, V693, V694, V695, V696, V697, V698, V699, V700, V701, V702, V703, V704, V705, V706, V707, V708, V709, V710, V711, V712, V711, V712 , V714, V715, V716 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V671, V672 and / or V680, V681 and / or V693, V694 and / or V700, V701 and / or V709, V710 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV717, -NV718V719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V720, -C (O) O-V721, -C (O) NH-V722, -C (O) NV723V724, -O-V725, -O (-V726-O) _d -H (d = 1, 2, 3, 4, 5), -O (-V727-O) _d -V728 (d = 1, 2, 3, 4, 5), -OC (O) -V729, -OC (O) -O-V730, -OC (O) -NHV731, -O-C (O)- NV732V733, -OP (O) (OV734) (OV735), -OSi (V736) (V737) (V738), -OS (O ₂ ) -V739, -NHC (O) -V740, -NV741C (O) -V742, -NH-C (O) -O-V743, -NH-C (O) -NH-V744, -NH-C (O ) -NV745V746, -NV747-C (O) -O-V748, -NV749-C (O) -NH-V750, -NV751-C (O) -NV752V753, -NHS (O ₂ ) -V754, -NV755S (O ₂ ) -V756, -S-V757, -S (O) -V758, -S (O ₂ ) -V759, -S (O ₂ ) NH-V760, -S (O ₂ ) NV761V762, -S (O ₂ ) O-V763, -P (O) (OV764) (OV765), -Si (V766) (V767) (V768) ";
At that time, V717, V718, V719, V720, V721, V722, V723, V724, V725, V726, V727, V728, V729, V730, V731, V732, V733, V734, V735, V736, V737, V738, V739, V739 , V741, V742, V743, V744, V745, V746, V747, V748, V749, V750, V751, V752, V753, V754, V755, V756, V757, V758, V759, V760, V761, V762, V763, 764 , V766, V767, V768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V723, V724 and / or V732, V733 and / or V745, V746 and / or V752, V753 and / or V761, V762 can each be taken together to form a "heterocyclyl";
(J) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV769, -NV770V771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V772, -C (O) O-V773, -C (O) NH-V774, -C (O) NV775V776, -O-V777, -O (-V778-O). _e -H (e = 1, 2, 3, 4, 5), -O (-V779-O) _e -V780 (e = 1, 2, 3, 4, 5), -OC (O) -V781, -OC (O) -O-V782, -OC (O) -NHV783, -O-C (O)- NV784V785, -OP (O) (OV786) (OV787), -OSi (V788) (V789) (V790), -OS (O ₂ ) -V791, -NHC (O) -V792, -NV793C (O) -V794, -NH-C (O) -O-V795, -NH-C (O) -NH-V796, -NH-C (O ) -NV797V798, -NV799-C (O) -O-V800, -NV801-C (O) -NH-V802, -NV803-C (O) -NV804V805, -NHS (O ₂ ) -V806, -NV807S (O ₂ ) -V808, -S-V809, -S (O) -V810, -S (O ₂ ) -V811, -S (O ₂ ) NH-V812, -S (O ₂ ) NV813V814, -S (O ₂ ) O-V815, -P (O) (OV816) (OV817), -Si (V818) (V819) (V820) ";
At that time, V769, V770, V771, V772, V773, V774, V775, V776, V777, V778, V779, V780, V781, V782, V783, V784, V785, V786, V787, V788, V789, V790, V791, V791 , V793, V794, V795, V796, V797, V798, V799, V800, V801, V802, V803, V804, V805, V806, V807, V808, V809, V810, V811, V812, V813, V814, V815, V816, V815, V816 , V818, V819, V820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V775, V776 and / or V784, V785 and / or V797, V798 and / or V804, V805 and / or V813, V814 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV821, -NV822V823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V824, -C (O) O-V825, -C (O) NH-V826, -C (O) NV827V828, -O-V829, -O (-V830-O) _f -H (f = 1, 2, 3, 4, 5), -O (-V831-O) _f -V832 (f = 1, 2, 3, 4, 5), -OC (O) -V833, -OC (O) -O-V834, -OC (O) -NHV835, -O-C (O)- NV836V837, -OP (O) (OV838) (OV839), -OSi (V840) (V841) (V842), -OS (O ₂ ) -V843, -NHC (O) -V844, -NV845C (O) -V846, -NH-C (O) -O-V847, -NH-C (O) -NH-V848, -NH-C (O ) -NV849V850, -NV851-C (O) -O-V852, -NV853-C (O) -NH-V854, -NV855-C (O) -NV856V857, -NHS (O ₂ ) -V858, -NV859S (O ₂ ) -V860, -S-V861, -S (O) -V862, -S (O ₂ ) -V863, -S (O ₂ ) NH-V864, -S (O ₂ ) NV865V866, -S (O ₂ ) O-V867, -P (O) (OV868) (OV869), -Si (V870) (V871) (V872) ";
At that time, V821, V822, V823, V824, V825, V826, V827, V828, V829, V830, V831, V832, V833, V834, V835, V836, V837, V838, V833, V840, V841, V842, V84, V84 , V845, V846, V847, V848, V849, V850, V851, V852, V853, V854, V855, V856, V857, V858, V859, V860, V861, V862, V863, V864, V865, V866, V867, 86 , V870, V871, V872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V827, V828 and / or V836, V837 and / or V849, V850 and / or V856, V857 and / or V865, V866 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV873, -NV874V875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V876, -C (O) O-V877, -C (O) NH-V878, -C (O) NV879V880, -O-V881, -O (-V882-O) _g -H (g = 1, 2, 3, 4, 5), -O (-V883-O) _g -V884 (g = 1, 2, 3, 4, 5), -OC (O) -V885, -OC (O) -O-V886, -OC (O) -NHV887, -O-C (O)- NV888V889, -OP (O) (OV890) (OV891), -OSi (V892) (V893) (V894), -OS (O ₂ ) -V895, -NHC (O) -V896, -NV897C (O) -V898, -NH-C (O) -O-V899, -NH-C (O) -NH-V900, -NH-C (O ) -NV901V902, -NV903-C (O) -O-V904, -NV905-C (O) -NH-V906, -NV907-C (O) -NV908V909, -NHS (O ₂ ) -V910, -NV911S (O ₂ ) -V912, -S-V913, -S (O) -V914, -S (O ₂ ) -V915, -S (O ₂ ) NH-V916, -S (O ₂ ) NV917V918, -S (O ₂ ) O-V919, -P (O) (OV920) (OV921), -Si (V922) (V923) (V924) ";
In that case, V873, V874, V875, V876, V877, V878, V879, V880, V881, V882, V883, V88, V885, V886, V887, V888, V889, V890, V891, V892, V893, V894, V895, V895 , V897, V898, V899, V900, V901, V902, V903, V904, V905, V906, V907, V908, V909, V910, V911, V912, V913, V914, V915, V916, V917, V918, V919, V920 , V922, V923, V924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V879, V880 and / or V888, V889 and / or V901, V902 and / or V908, V909 and / or V917, V918 can each be taken together to form a "heterocyclyl";
(K) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV925, -NV926V927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V928, -C (O) O-V929, -C (O) NH-V930, -C (O) NV931V932, -O-V933, -O (-V934-O) _h -H (h = 1, 2, 3, 4, 5), -O (-V935-O) _h -V936 (h = 1, 2, 3, 4, 5), -OC (O) -V937, -OC (O) -O-V938, -OC (O) -NHV939, -O-C (O)- NV940V941, -OP (O) (OV942) (OV943), -OSi (V944) (V945) (V946), -OS (O ₂ ) -V947, -NHC (O) -V948, -NV949C (O) -V950, -NH-C (O) -O-V951, -NH-C (O) -NH-V952, -NH-C (O ) -NV953V954, -NV955-C (O) -O-V956, -NV957-C (O) -NH-V958, -NV959-C (O) -NV960V961, -NHS (O ₂ ) -V962, -NV963S (O ₂ ) -V964, -S-V965, -S (O) -V966, -S (O ₂ ) -V967, -S (O ₂ ) NH-V968, -S (O ₂ ) NV969V970, -S (O ₂ ) O-V971, -P (O) (OV972) (OV973), -Si (V974) (V975) (V976) ";
At that time, V925, V926, V927, V928, V929, V930, V931, V932, V933, V934, V935, V936, V937, V938, V939, V940, V941, V942, V943, V944, V945, V946, V947, V948 , V949, V950, V951, V952, V953, V954, V955, V955, V957, V958, V959, V960, V961, V962, V963, V964, V965, V966, V967, V968, V969, V970, V971, V972 , V974, V975, V976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V931, V932 and / or V940, V941 and / or V953, V954 and / or V960, V961 and / or V969, V970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV977, -NV978V979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V980, -C (O) O-V981, -C (O) NH-V982, -C (O) NV983V984, -O-V985, -O (-V986-O) _i -H (i = 1, 2, 3, 4, 5), -O (-V987-O) _i -V988 (i = 1, 2, 3, 4, 5), -OC (O) -V989, -OC (O) -O-V990, -OC (O) -NHV991, -O-C (O)- NV992V993, -OP (O) (OV994) (OV995), -OSi (V996) (V997) (V998), -OS (O ₂ ) -V999, -NHC (O) -V1000, -NV1001C (O) -V1002, -NH-C (O) -O-V1003, -NH-C (O) -NH-V1004, -NH-C (O ) -NV1005V1006, -NV1007-C (O) -O-V1008, -NV1009-C (O) -NH-V1010, -NV1011-C (O) -NV1012V1013, -NHS (O ₂ ) -V1014, -NV1015S (O ₂ ) -V1016, -S-V1017, -S (O) -V1018, -S (O ₂ ) -V1019, -S (O ₂ ) NH-V1020, -S (O ₂ ) NV1021V1022, -S (O ₂ ) O-V1023, -P (O) (OV1024) (OV1025), -Si (V1026) (V1027) (V1028) ";
At that time, V977, V978, V979, V980, V981, V982, V983, V984, V985, V986, V987, V988, V989, V990, V991, V992, V993, V994, V995, V996, V997, V998, V999, 1000 , V1001, V1002, V1003, V1004, V1005, V1006, V1007, V1008, V1009, V1010, V1011, V1012, V1013, V1014, V1015, V1016, V1017, V1018, V1019, V1020, V1021, V1022, V1023, V1024 , V1026, V1027, V1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V983, V984 and / or V992, V993 and / or V1005, V1006 and / or V1012, V1013 and / or V1021, V1022 can each be taken together to form a "heterocyclyl";
(L) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1029, -NV1030V1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1032, -C (O) O-V1033, -C (O) NH-V1034, -C (O) NV1035V1036, -O-V1037, -O (-V1038-O) _j -H (j = 1, 2, 3, 4, 5), -O (-V1039-O) _j -V1040 (j = 1, 2, 3, 4, 5), -OC (O) -V1041, -OC (O) -O-V1042, -OC (O) -NHV1043, -O-C (O)- NV1044V1045, -OP (O) (OV1046) (OV1047), -OSi (V1048) (V1049) (V1050), -OS (O ₂ ) -V1051, -NHC (O) -V1052, -NV1053C (O) -V1054, -NH-C (O) -O-V1055, -NH-C (O) -NH-V1056, -NH-C (O ) -NV1057V1058, -NV1059-C (O) -O-V1060, -NV1061-C (O) -NH-V1062, -NV1063-C (O) -NV1064V1065, -NHS (O ₂ ) -V1066, -NV1067S (O ₂ ) -V1068, -S-V1069, -S (O) -V1070, -S (O ₂ ) -V1071, -S (O ₂ ) NH-V1072, -S (O ₂ ) NV1073V1074, -S (O ₂ ) O-V1075, -P (O) (OV1076) (OV1077), -Si (V1078) (V1079) (V1080) ";
At that time, V1029, V1030, V1031, V1032, V1033, V1034, V1035, V1036, V1037, V1038, V1039, V1040, V1041, V1042, V1043, V1044, V1045, V1046, V1047, V1048, V1049, V1050, V1051, V1052, . , V1078, V1079, V1080 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1035, V1036 and / or V1044, V1045 and / or V1057, V1058 and / or V1064, V1065 and / or V1073, V1074 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1081, -NV1082V1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1084, -C (O) O-V1085, -C (O) NH-V1086, -C (O) NV1087V1088, -O-V1089, -O (-V1090-O) _k -H (k = 1, 2, 3, 4, 5), -O (-V1091-O) _k -V1092 (k = 1, 2, 3, 4, 5), -OC (O) -V1093, -OC (O) -O-V1094, -OC (O) -NHV1095, -O-C (O)- NV1096V1097, -OP (O) (OV1098) (OV1099), -OSi (V1100) (V1101) (V1102), -OS (O ₂ ) -V1103, -NHC (O) -V1104, -NV1105C (O) -V1106, -NH-C (O) -O-V1107, -NH-C (O) -NH-V1108, -NH-C (O ) -NV1109V1110, -NV1111-C (O) -O-V1112, -NV1113-C (O) -NH-V1114, -NV1115-C (O) -NV1116V1117, -NHS (O ₂ ) -V1118, -NV1119S (O ₂ ) -V1120, -S-V1121, -S (O) -V1122, -S (O ₂ ) -V1123, -S (O ₂ ) NH-V1124, -S (O ₂ ) NV1125V1126, -S (O ₂ ) O-V1127, -P (O) (OV1128) (OV1129), -Si (V1130) (V1131) (V1132) ";
At that time, V1081, V1082, V1083, V1084, V1085, V1086, V1087, V1088, V1089, V1090, V1091, V1092, V1093, V1094, V1095, V1096, V1097, V1098, V1099, V1100, V1101, V1102, V1103, V1104 , V1105, V1106, V1107, V1108, V1109, V1110, V1111, V1112, V1113, V1114, V1115, V1116, V1117, V1118, V1119, V1120, V1121, V1122, V1123, V1124, V1125, V1126, V1127, V1128 , V1130, V1131, V1132, independently of one another, are “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1087, V1088 and / or V1096, V1097 and / or V1109, V1110 and / or V1116, V1117 and / or V1125, V1126 may each be taken together to form a "heterocyclyl";
(M) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -V1133, -C (O) O-V1134, -C (O)- NV1135V1136, -S (O ₂ ) -V1137, -S (O ₂ ) O-V1138 ";
At that time, V1133, V1134, V1135, V1136, V1137, and V1138 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, V1135, V1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1139, -NV1140V1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1142, -C (O) O-V1143, -C (O) NH-V1144, -C (O) NV1145V1146, -O-V1147, -O (-V1148-O) _l -H (l = 1, 2, 3, 4, 5), -O (-V1149-O) _l -V1150 (l = 1, 2, 3, 4, 5), -OC (O) -V1151, -OC (O) -O-V1152, -OC (O) -NHV1153, -O-C (O)- NV1154V1155, -OP (O) (OV1156) (OV1157), -OSi (V1158) (V1159) (V1160), -OS (O ₂ ) -V1161, -NHC (O) -V1162, -NV1163C (O) -V1164, -NH-C (O) -O-V1165, -NH-C (O) -NH-V1166, -NH-C (O ) -NV1167V1168, -NV1169-C (O) -O-V1170, -NV1171-C (O) -NH-V1172, -NV1173-C (O) -NV1174V1175, -NHS (O ₂ ) -V1176, -NV1177S (O ₂ ) -V1178, -S-V1179, -S (O) -V1180, -S (O ₂ ) -V1181, -S (O ₂ ) NH-V1182, -S (O ₂ ) NV1183V1184, -S (O ₂ ) O-V1185, -P (O) (OV1186) (OV1187), -Si (V1188) (V1189) (V1190) ";
At that time, V1139, V1140, V1141, V1142, V1143, V1144, V1145, V1146, V1147, V1148, V1149, V1150, V1151, V1152, V1153, V1154, V1155, V1156, V1157, V1158, V1159, V1160, V1160, V1160 , V1163, V1164, V1165, V1166, V1167, V1168, V1169, V1170, V1171, V1172, V1173, V1174, V1175, V1176, V1177, V1178, V1179, V1180, V1181, V1182, V1183, V1186, V1185, V1186, , V1188, V1189, and V1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1145, V1146 and / or V1154, V1155 and / or V1167, V1168 and / or V1174, V1175 and / or V1183, V1184 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1191, -NV1192V1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1194, -C (O) O-V1195, -C (O) NH-V1196, -C (O) NV1197V1198, -O-V1199, -O (-V1200-O). _m -H (m = 1, 2, 3, 4, 5), -O (-V1201-O) _m -V1202 (m = 1, 2, 3, 4, 5), -OC (O) -V1203, -OC (O) -O-V1204, -OC (O) -NHV1205, -O-C (O)- NV1206V1207, -OP (O) (OV1208) (OV1209), -OSi (V1210) (V1211) (V1212), -OS (O ₂ ) -V1213, -NHC (O) -V1214, -NV1215C (O) -V1216, -NH-C (O) -O-V1217, -NH-C (O) -NH-V1218, -NH-C (O ) -NV1219V1220, -NV1221-C (O) -O-V1222, -NV1223-C (O) -NH-V1224, -NV1225-C (O) -NV1226V1227, -NHS (O ₂ ) -V1228, -NV1229S (O ₂ ) -V1230, -S-V1231, -S (O) -V1232, -S (O ₂ ) -V1233, -S (O ₂ ) NH-V1234, -S (O ₂ ) NV1235V1236, -S (O ₂ ) O-V1237, -P (O) (OV1238) (OV1239), -Si (V1240) (V1241) (V1242) ";
At that time, V1191, V1192, V1193, V1194, V1195, V1196, V1197, V1198, V1199, V1200, V1201, V1202, V1203, V1204, V1205, V1206, V1207, V1208, V1209, V1210, V1211, V1212, V1213, V1213 , V1215, V1216, V1217, V1218, V1219, V1220, V1221, V1222, V1223, V1224, V1225, V1226, V1227, V1228, V1229, V1230, V1231, V1232, V1233, V1234, V1235, V1236, V1237, V1238 , V1240, V1241, and V1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1197, V1198 and / or V1206, V1207 and / or V1219, V1220 and / or V1226, V1227 and / or V1235, V1236 can each be taken together to form a "heterocyclyl";
Or
(C)
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are “substituted alkyl”, wherein “substituted alkyl” is selected from the group consisting of: Substituted by at least one substituent:
(A) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1, -NW2W3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W4, -C (O) O-W5, -C (O) NH-W6, -C (O) NW7W8, -O-W9, -O (-W10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-W11-O) _r -W12 (r = 1, 2, 3, 4, 5), -OC (O) -W13, -OC (O) -O-W14, -OC (O) -NHW15, -O-C (O)- NW16W17, -OP (O) (OW18) (OW19), -OSi (W20) (W21) (W22), -OS (O ₂ ) -W23, -NHC (O) -W24, -NW25C (O) -W26, -NH-C (O) -O-W27, -NH-C (O) -NH-W28, -NH-C (O ) -NW29W30, -NW31-C (O) -O-W32, -NW33-C (O) -NH-W34, -NW35-C (O) -NW36W37, -NHS (O ₂ ) -W38, -NW39S (O ₂ ) -W40, -S-W41, -S (O) -W42, -S (O ₂ ) -W43, -S (O ₂ ) NH-W44, -S (O ₂ ) NW45W46, -S (O ₂ ) O-W47, -P (O) (OW48) (OW49), -Si (W50) (W51) (W52) ";
At that time, W1, W2, W3, W4, W5, W6, W7, W8, W9, W10, W11, W12, W13, W14, W15, W16, W17, W18, W19, W20, W21, W22, W23, W24 , W25, W26, W27, W28, W29, W30, W31, W32, W33, W34, W35, W36, W37, W38, W39, W40, W41, W42, W43, W44, W45, W46, W47, W48, W49 , W50, W51, W52 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, W7, W8 and / or W16, W17 and / or Or W29, W30 and / or W36, W37 and / or W45, W46 may each be taken together to form a "heterocyclyl";
However, "-C (O) NH-aryl", "-C (O) NH-heteroaryl", "-C (O) NH-cycloalkyl", "-C (O) NH-heterocyclyl" Further substituted with at least one substituent selected from the substituent group (i)
In this case, the substituents of the substituent group (a) may optionally be further substituted with at least one substituent selected from the group consisting of the following, independently or from the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW53, -NW54W55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W56, -C (O) O-W57, -C (O) NH-W58, -C (O) NW59W60, -O-W61, -O (-W62-O) _s -H (s = 1, 2, 3, 4, 5), -O (-W63-O) _s -W64 (s = 1, 2, 3, 4, 5), -OC (O) -W65, -OC (O) -O-W66, -OC (O) -NHW67, -O-C (O)- NW68W69, -OP (O) (OW70) (OW71), -OSi (W72) (W73) (W74), -OS (O ₂ ) -W75, -NHC (O) -W76, -NW77C (O) -W78, -NH-C (O) -O-W79, -NH-C (O) -NH-W80, -NH-C (O ) -NW81W82, -NW83-C (O) -O-W84, -NW85-C (O) -NH-W86, -NW87-C (O) -NW88W89, -NHS (O ₂ ) -W90, -NW91S (O ₂ ) -W92, -S-W93, -S (O) -W94, -S (O ₂ ) -W95, -S (O ₂ ) NH-W96, -S (O ₂ ) NW97W98, -S (O ₂ ) O-W99, -P (O) (OW100) (OW101), -Si (W102) (W103) (W104) ";
At that time, W53, W54, W55, W56, W57, W58, W59, W60, W61, W62, W63, W64, W65, W66, W67, W68, W69, W70, W71, W72, W73, W74, W75, W76 W77, W78, W79, W80, W81, W82, W83, W84, W85, W86, W87, W88, W89, W90, W91, W92, W93, W94, W95, W96, W97, W98, W99, W100, W101 , W102, W103, W104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W59, W60 and / or W68, W69 and / or W81, W82 and / or W88, W89 and / or W97, W98 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW105, -NW106W107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W108, -C (O) O-W109, -C (O) NH-W110, -C (O) NW111W112, -O-W113, -O (-W114-O) _t -H (t = 1, 2, 3, 4, 5), -O (-W115-O) _t -W116 (t = 1, 2, 3, 4, 5), -OC (O) -W117, -OC (O) -O-W118, -OC (O) -NHW119, -O-C (O)- NW120W121, -OP (O) (OW122) (OW123), -OSi (W124) (W125) (W126), -OS (O ₂ ) -W127, -NHC (O) -W128, -NW129C (O) -W130, -NH-C (O) -O-W131, -NH-C (O) -NH-W132, -NH-C (O ) -NW133W134, -NW135-C (O) -O-W136, -NW137-C (O) -NH-W138, -NW139-C (O) -NW140W141, -NHS (O ₂ ) -W142, -NW143S (O ₂ ) -W144, -S-W145, -S (O) -W146, -S (O ₂ ) -W147, -S (O ₂ ) NH-W148, -S (O ₂ ) NW149W150, -S (O ₂ ) O-W151, -P (O) (OW152) (OW153), -Si (W154) (W155) (W156) ";
At that time, W105, W106, W107, W108, W109, W110, W111, W112, W113, W114, W115, W116, W117, W118, W119, W120, W121, W122, W123, W124, W125, W126, W127, W128 , W129, W130, W131, W132, W133, W134, W135, W136, W137, W138, W139, W140, W141, W142, W143, W144, W145, W146, W147, W148, W149, W150, W151, W152, W153 , W154, W155, W156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W111, W112 and / or W120, W121 and / or W133, W134 and / or W140, W141 and / or W149, W150 may be taken together to form a “heterocyclyl”;
Or
One or both radicals Z3, Z4 of the radicals Z3, Z4 are independent of each other ₉ ~ C ₃₀ -Alkyl ";
At that time, "C ₉ ~ C ₃₀ “Alkyl” is optionally substituted by at least one substituent, independently of one another, selected from the group consisting of the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW157, -NW158W159, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W160, -C (O) O-W161, -C (O) NH-W162, -C (O) NW163W164, -O-W165, -O (-W166-O) _u -H (u = 1, 2, 3, 4, 5), -O (-W167-O) _u -W168 (u = 1, 2, 3, 4, 5), -OC (O) -W169, -OC (O) -O-W170, -OC (O) -NHW171, -O-C (O)- NW172W173, -OP (O) (OW174) (OW175), -OSi (W176) (W177) (W178), -OS (O ₂ ) -W179, -NHC (O) -W180, -NW181C (O) -W182, -NH-C (O) -O-W183, -NH-C (O) -NH-W184, -NH-C (O ) -NW185W186, -NW187-C (O) -O-W188, -NW189-C (O) -NH-W190, -NW191-C (O) -NW192W193, -NHS (O ₂ ) -W194, -NW195S (O ₂ ) -W196, -S-W197, -S (O) -W198, -S (O ₂ ) -W199, -S (O ₂ ) NH-W200, -S (O ₂ ) NW201W202, -S (O ₂ ) O-W203, -P (O) (OW204) (OW205), -Si (W206) (W207) (W208) ";
At that time, W157, W158, W159, W160, W161, W162, W163, W164, W165, W166, W167, W168, W169, W170, W171, W172, W173, W174, W175, W176, W177, W178, W179, W180 W181, W182, W183, W184, W185, W186, W187, W188, W189, W190, W191, W192, W193, W194, W195, W196, W197, W198, W199, W200, W201, W202, W203, W204, W205 , W206, W207, W208 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W163, W164 and / or W172, W173 and / or W185, W186 and / or W192, W193 and / or W201, W202 may be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW209, -NW210W211, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W212, -C (O) O-W213, -C (O) NH-W214, -C (O) NW215W216, -O-W217, -O (-W218-O) _v -H (v = 1, 2, 3, 4, 5), -O (-W219-O) _v -W220 (v = 1, 2, 3, 4, 5), -OC (O) -W221, -OC (O) -O-W222, -OC (O) -NHW223, -O-C (O)- NW224W225, -OP (O) (OW226) (OW227), -OSi (W228) (W229) (W230), -OS (O ₂ ) -W231, -NHC (O) -W232, -NW233C (O) -W234, -NH-C (O) -O-W235, -NH-C (O) -NH-W236, -NH-C (O ) -NW237W238, -NW239-C (O) -O-W240, -NW241-C (O) -NH-W242, -NW243-C (O) -NW244W245, -NHS (O ₂ ) -W246, -NW247S (O ₂ ) -W248, -S-W249, -S (O) -W250, -S (O ₂ ) -W251, -S (O ₂ ) NH-W252, -S (O ₂ ) NW253W254, -S (O ₂ ) O-W255, -P (O) (OW256) (OW257), -Si (W258) (W259) (W260) ";
At that time, W209, W210, W211, W212, W213, W214, W215, W216, W217, W218, W219, W220, W221, W222, W223, W224, W225, W226, W227, W228, W229, W230, W231, W232 , W233, W234, W235, W236, W237, W238, W239, W240, W241, W242, W243, W244, W245, W246, W247, W248, W249, W250, W251, W252, W253, W254, W255, W256, 255 , W258, W259, W260 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from W215, W216 and / or W224, W225 and / or Or W237, W238 and / or W244, W245 and / or W253, W254 may each be taken together to form a "heterocyclyl";
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(B) hydrogen;
(C) halogen, F, Cl, Br, I;
(D) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW457, -NW458W459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W460, -C (O) O-W461, -C (O) NH-W462, -C (O) NW463W464, -O-W465, -O (-W466-O) _x -H (x = 1, 2, 3, 4, 5), -O (-W467-O) _x -W468 (x = 1, 2, 3, 4, 5), -OC (O) -W469, -OC (O) -O-W470, -OC (O) -NHW471, -O-C (O)- NW472W473, -OP (O) (OW474) (OW475), -OSi (W476) (W477) (W478), -OS (O ₂ ) -W479, -NHC (O) -W480, -NW481C (O) -W482, -NH-C (O) -O-W483, -NH-C (O) -NH-W484, -NH-C (O ) -NW485W486, -NW487-C (O) -O-W488, -NW489-C (O) -NH-W490, -NW491-C (O) -NW492W493, -NHS (O ₂ ) -W494, -NW495S (O ₂ ) -W496, -S-W497, -S (O) -W498, -S (O ₂ ) -W499, -S (O ₂ ) NH-W500, -S (O ₂ ) NW501W502, -S (O ₂ ) O-W503, -P (O) (OW504) (OW505), -Si (W506) (W507) (W508) ";
At that time, W457, W458, W459, W460, W461, W462, W463, W464, W465, W466, W467, W468, W469, W470, W471, W472, W473, W474, W475, W476, W477, W478, W479, W480 W481, W482, W483, W484, W485, W486, W487, W488, W489, W490, W491, W492, W493, W494, W495, W496, W497, W498, W499, W500, W501, W502, W503, W504, 50 , W506, W507, W508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W463, W464 and / or W472, W473 and / or W485, W486 and / or W492, W493 and / or W501, W502 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW509, -NW510W511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W512, -C (O) O-W513, -C (O) NH-W514, -C (O) NW515W516, -O-W517, -O (-W518-O) _y -H (y = 1, 2, 3, 4, 5), -O (-W519-O) _y -W520 (y = 1, 2, 3, 4, 5), -OC (O) -W521, -OC (O) -O-W522, -OC (O) -NHW523, -O-C (O)- NW524W525, -OP (O) (OW526) (OW527), -OSi (W528) (W529) (W530), -OS (O ₂ ) -W531, -NHC (O) -W532, -NW533C (O) -W534, -NH-C (O) -O-W535, -NH-C (O) -NH-W536, -NH-C (O ) -NW537W538, -NW539-C (O) -O-W540, -NW541-C (O) -NH-W542, -NW543-C (O) -NW544W545, -NHS (O ₂ ) -W546, -NW547S (O ₂ ) -W548, -S-W549, -S (O) -W550, -S (O ₂ ) -W551, -S (O ₂ ) NH-W552, -S (O ₂ ) NW553W554, -S (O ₂ ) O-W555, -P (O) (OW556) (OW557), -Si (W558) (W559) (W560) ";
At that time, W509, W510, W511, W512, W513, W514, W515, W516, W517, W518, W519, W520, W521, W522, W523, W524, W525, W526, W527, W528, W529, W530, W531, W532 , W533, W534, W535, W536, W537, W538, W539, W540, W541, W542, W543, W544, W545, W546, W547, W548, W549, W550, W551, W552, W553, W554, W555, W556, W555, W556 , W558, W559, W560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W515, W516 and / or W524, W525 and / or W537, W538 and / or W544, W545 and / or W553, W554 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW561, -NW562W563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W564, -C (O) O-W565, -C (O) NH-W566, -C (O) NW567W568, -O-W569, -O (-W570-O) _z -H (z = 1, 2, 3, 4, 5), -O (-W571-O) _z -W572 (z = 1, 2, 3, 4, 5), -OC (O) -W573, -OC (O) -O-W574, -OC (O) -NHW575, -O-C (O)- NW576W577, -OP (O) (OW578) (OW579), -OSi (W580) (W581) (W582), -OS (O ₂ ) -W583, -NHC (O) -W584, -NW585C (O) -W586, -NH-C (O) -O-W587, -NH-C (O) -NH-W588, -NH-C (O ) -NW589W590, -NW591-C (O) -O-W592, -NW593-C (O) -NH-W594, -NW595-C (O) -NW596W597, -NHS (O ₂ ) -W598, -NW599S (O ₂ ) -W600, -S-W601, -S (O) -W602, -S (O ₂ ) -W603, -S (O ₂ ) NH-W604, -S (O ₂ ) NW605W606, -S (O ₂ ) O-W607, -P (O) (OW608) (OW609), -Si (W610) (W611) (W612) ";
At that time, W561, W562, W563, W564, W565, W566, W567, W568, W569, W570, W571, W572, W573, W574, W575, W576, W577, W578, W579, W580, W581, W582, W583, W584 W585, W586, W587, W588, W589, W590, W591, W592, W593, W594, W595, W596, W597, W598, W599, W600, W601, W602, W603, W604, W605, W606, W607, W608, W608 , W610, W611, W612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W567, W568 and / or W576, W577 and / or W589, W590 and / or W596, W597 and / or W605, W606 may each be taken together to form a “heterocyclyl”;
(E) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW613, -NW614W615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W616, -C (O) O-W617, -C (O) NH-W618, -C (O) NW619W620, -O-W621, -O (-W622-O) _a -H (a = 1, 2, 3, 4, 5), -O (-W623-O) _a -W624 (a = 1, 2, 3, 4, 5), -OC (O) -W625, -OC (O) -O-W626, -OC (O) -NHW627, -O-C (O)- NW628W629, -OP (O) (OW630) (OW631), -OSi (W632) (W633) (W634), -OS (O ₂ ) -W635, -NHC (O) -W636, -NW637C (O) -W638, -NH-C (O) -O-W639, -NH-C (O) -NH-W640, -NH-C (O ) -NW641W642, -NW643-C (O) -O-W644, -NW645-C (O) -NH-W646, -NW647-C (O) -NW648W649, -NHS (O ₂ ) -W650, -NW651S (O ₂ ) -W652, -S-W653, -S (O) -W654, -S (O ₂ ) -W655, -S (O ₂ ) NH-W656, -S (O ₂ ) NW657W658, -S (O ₂ ) O-W659, -P (O) (OW660) (OW661), -Si (W662) (W663) (W664) ";
In that case, W613, W614, W615, W616, W617, W618, W619, W620, W621, W622, W623, W624, W625, W626, W627, W628, W629, W630, W631, W632, W633, W634, W635, W636, W636 , W637, W638, W639, W640, W641, W642, W643, W644, W645, W646, W647, W648, W649, W650, W651, W652, W653, W654, W655, W656, W657, W658, W659, W660, W659, W660 , W662, W663, W664 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W619, W620 and / or W628, W629 and / or W641, W642 and / or W648, W649 and / or W657, W658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW665, -NW666W667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W668, -C (O) O-W669, -C (O) NH-W670, -C (O) NW671W672, -O-W673, -O (-W674-O) _b -H (b = 1, 2, 3, 4, 5), -O (-W675-O) _b -W676 (b = 1, 2, 3, 4, 5), -OC (O) -W677, -OC (O) -O-W678, -OC (O) -NHW679, -O-C (O)- NW680W681, -OP (O) (OW682) (OW683), -OSi (W684) (W685) (W686), -OS (O ₂ ) -W687, -NHC (O) -W688, -NW689C (O) -W690, -NH-C (O) -O-W691, -NH-C (O) -NH-W692, -NH-C (O ) -NW693W694, -NW695-C (O) -O-W696, -NW697-C (O) -NH-W698, -NW699-C (O) -NW700W701, -NHS (O ₂ ) -W702, -NW703S (O ₂ ) -W704, -S-W705, -S (O) -W706, -S (O ₂ ) -W707, -S (O ₂ ) NH-W708, -S (O ₂ ) NW709W710, -S (O ₂ ) O-W711, -P (O) (OW712) (OW713), -Si (W714) (W715) (W716) ";
At that time, W665, W666, W667, W668, W669, W670, W671, W672, W673, W674, W675, W676, W677, W678, W679, W680, W681, W682, W683, W684, W685, W686, W687, W688 , W689, W690, W691, W692, W693, W694, W695, W696, W697, W698, W699, W700, W701, W702, W703, W704, W705, W706, W707, W708, W709, W710, W711, W712, W711 , W714, W715, W716 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W671, W672 and / or W680, W681 and / or W693, W694 and / or W700, W701 and / or W709, W710 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW717, -NW718W719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W720, -C (O) O-W721, -C (O) NH-W722, -C (O) NW723W724, -O-W725, -O (-W726-O) _c -H (c = 1, 2, 3, 4, 5), -O (-W727-O) _c -W728 (c = 1, 2, 3, 4, 5), -OC (O) -W729, -OC (O) -O-W730, -OC (O) -NHW731, -O-C (O)- NW732W733, -OP (O) (OW734) (OW735), -OSi (W736) (W737) (W738), -OS (O ₂ ) -W739, -NHC (O) -W740, -NW741C (O) -W742, -NH-C (O) -O-W743, -NH-C (O) -NH-W744, -NH-C (O ) -NW745W746, -NW747-C (O) -O-W748, -NW749-C (O) -NH-W750, -NW751-C (O) -NW752W753, -NHS (O ₂ ) -W754, -NW755S (O ₂ ) -W756, -S-W757, -S (O) -W758, -S (O ₂ ) -W759, -S (O ₂ ) NH-W760, -S (O ₂ ) NW761W762, -S (O ₂ ) O-W763, -P (O) (OW764) (OW765), -Si (W766) (W767) (W768) ";
At that time, W717, W718, W719, W720, W721, W722, W723, W724, W725, W726, W727, W728, W729, W730, W731, W732, W733, W734, W735, W736, W737, W738, W739, W7 W741, W742, W743, W744, W745, W746, W747, W748, W749, W750, W751, W752, W753, W754, W755, W756, W757, W758, W759, W760, W761, W762, W763, W764 , W766, W767, W768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W723, W724 and / or W732, W733 and / or W745, W746 and / or W752, W753 and / or W761, W762 can each be taken together to form a "heterocyclyl";
(F) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW769, -NW770W771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W772, -C (O) O-W773, -C (O) NH-W774, -C (O) NW775W776, -O-W777, -O (-W778-O). _d -H (d = 1, 2, 3, 4, 5), -O (-W779-O) _d -W780 (d = 1, 2, 3, 4, 5), -OC (O) -W781, -OC (O) -O-W782, -OC (O) -NHW783, -O-C (O)- NW784W785, -OP (O) (OW786) (OW787), -OSi (W788) (W789) (W790), -OS (O ₂ ) -W791, -NHC (O) -W792, -NW793C (O) -W794, -NH-C (O) -O-W795, -NH-C (O) -NH-W796, -NH-C (O ) -NW797W798, -NW799-C (O) -O-W800, -NW801-C (O) -NH-W802, -NW803-C (O) -NW804W805, -NHS (O ₂ ) -W806, -NW807S (O ₂ ) -W808, -S-W809, -S (O) -W810, -S (O ₂ ) -W811, -S (O ₂ ) NH-W812, -S (O ₂ ) NW813W814, -S (O ₂ ) O-W815, -P (O) (OW816) (OW817), -Si (W818) (W819) (W820) ";
At that time, W769, W770, W771, W772, W773, W774, W775, W776, W777, W778, W779, W780, W781, W782, W783, W784, W785, W786, W787, W788, W789, W790, W791, W79 , W793, W794, W795, W796, W797, W798, W799, W800, W801, W802, W803, W804, W805, W806, W807, W808, W809, W810, W811, W812, W813, W814, W815, W816, , W818, W819, W820 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W775, W776 and / or W784, W785 and / or W797, W798 and / or W804, W805 and / or W813, W814 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW821, -NW822W823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W824, -C (O) O-W825, -C (O) NH-W826, -C (O) NW827W828, -O-W829, -O (-W830-O) _e -H (e = 1, 2, 3, 4, 5), -O (-W831-O) _e -W832 (e = 1, 2, 3, 4, 5), -OC (O) -W833, -OC (O) -O-W834, -OC (O) -NHW835, -O-C (O)- NW836W837, -OP (O) (OW838) (OW839), -OSi (W840) (W841) (W842), -OS (O ₂ ) -W843, -NHC (O) -W844, -NW845C (O) -W846, -NH-C (O) -O-W847, -NH-C (O) -NH-W848, -NH-C (O ) -NW849W850, -NW851-C (O) -O-W852, -NW853-C (O) -NH-W854, -NW855-C (O) -NW856W857, -NHS (O ₂ ) -W858, -NW859S (O ₂ ) -W860, -S-W861, -S (O) -W862, -S (O ₂ ) -W863, -S (O ₂ ) NH-W864, -S (O ₂ ) NW865W866, -S (O ₂ ) O-W867, -P (O) (OW868) (OW869), -Si (W870) (W871) (W872) ";
At that time, W821, W822, W823, W824, W825, W826, W827, W828, W829, W830, W831, W832, W833, W834, W835, W836, W837, W838, W839, W840, W841, W842, W843, W84 W845, W846, W847, W848, W849, W850, W851, W852, W853, W854, W855, W856, W857, W858, W859, W860, W861, W862, W863, W864, W865, W866, W867, W868, W867, W868 , W870, W871, W872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W827, W828 and / or W836, W837 and / or W849, W850 and / or W856, W857 and / or W865, W866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW873, -NW874W875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W876, -C (O) O-W877, -C (O) NH-W878, -C (O) NW879W880, -O-W881, -O (-W882-O) _f -H (f = 1, 2, 3, 4, 5), -O (-W883-O) _f -W884 (f = 1, 2, 3, 4, 5), -OC (O) -W885, -OC (O) -O-W886, -OC (O) -NHW887, -O-C (O)- NW888W889, -OP (O) (OW890) (OW891), -OSi (W892) (W893) (W894), -OS (O ₂ ) -W895, -NHC (O) -W896, -NW897C (O) -W898, -NH-C (O) -O-W899, -NH-C (O) -NH-W900, -NH-C (O ) -NW901W902, -NW903-C (O) -O-W904, -NW905-C (O) -NH-W906, -NW907-C (O) -NW908W909, -NHS (O ₂ ) -W910, -NW911S (O ₂ ) -W912, -S-W913, -S (O) -W914, -S (O ₂ ) -W915, -S (O ₂ ) NH-W916, -S (O ₂ ) NW917W918, -S (O ₂ ) O-W919, -P (O) (OW920) (OW921), -Si (W922) (W923) (W924) ";
In that case, W873, W874, W875, W876, W877, W878, W879, W880, W881, W882, W883, W884, W885, W886, W887, W888, W889, W890, W891, W892, W893, W894, W895, W896 W897, W898, W899, W900, W901, W902, W903, W904, W905, W906, W907, W908, W909, W910, W911, W912, W913, W914, W915, W916, W917, W918, W919, W920, W921, W920 , W922, W923, W924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W879, W880 and / or W888, W889 and / or W901, W902 and / or W908, W909 and / or W917, W918 may each be taken together to form a “heterocyclyl”;
(G) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW925, -NW926W927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W928, -C (O) O-W929, -C (O) NH-W930, -C (O) NW931W932, -O-W933, -O (-W934-O) _g -H (g = 1, 2, 3, 4, 5), -O (-W935-O) _g -W936 (g = 1, 2, 3, 4, 5), -OC (O) -W937, -OC (O) -O-W938, -OC (O) -NHW939, -O-C (O)- NW940W941, -OP (O) (OW942) (OW943), -OSi (W944) (W945) (W946), -OS (O ₂ ) -W947, -NHC (O) -W948, -NW949C (O) -W950, -NH-C (O) -O-W951, -NH-C (O) -NH-W952, -NH-C (O ) -NW953W954, -NW955-C (O) -O-W956, -NW957-C (O) -NH-W958, -NW959-C (O) -NW960W961, -NHS (O ₂ ) -W962, -NW963S (O ₂ ) -W964, -S-W965, -S (O) -W966, -S (O ₂ ) -W967, -S (O ₂ ) NH-W968, -S (O ₂ ) NW969W970, -S (O ₂ ) O-W971, -P (O) (OW972) (OW973), -Si (W974) (W975) (W976) ";
At that time, W925, W926, W927, W928, W929, W930, W931, W932, W933, W934, W935, W936, W937, W938, W939, W940, W941, W942, W943, W944, W945, W946, W947, W948 , W949, W950, W951, W952, W953, W954, W955, W956, W957, W958, W959, W960, W961, W962, W963, W964, W965, W966, W967, W968, W969, W970, W971, W972 , W974, W975, W976 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W931, W932 and / or W940, W941 and / or W953, W954 and / or W960, W961 and / or W969, W970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW977, -NW978W979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W980, -C (O) O-W981, -C (O) NH-W982, -C (O) NW983W984, -O-W985, -O (-W986-O) _h -H (h = 1, 2, 3, 4, 5), -O (-W987-O) _h -W988 (h = 1, 2, 3, 4, 5), -OC (O) -W989, -OC (O) -O-W990, -OC (O) -NHW991, -O-C (O)- NW992W993, -OP (O) (OW994) (OW995), -OSi (W996) (W997) (W998), -OS (O ₂ ) -W999, -NHC (O) -W1000, -NW1001C (O) -W1002, -NH-C (O) -O-W1003, -NH-C (O) -NH-W1004, -NH-C (O ) -NW1005W1006, -NW1007-C (O) -O-W1008, -NW1009-C (O) -NH-W1010, -NW1011-C (O) -NW1012W1013, -NHS (O ₂ ) -W1014, -NW1015S (O ₂ ) -W1016, -S-W1017, -S (O) -W1018, -S (O ₂ ) -W1019, -S (O ₂ ) NH-W1020, -S (O ₂ ) NW1021W1022, -S (O ₂ ) O-W1023, -P (O) (OW1024) (OW1025), -Si (W1026) (W1027) (W1028) ";
In that case, W977, W978, W979, W980, W981, W982, W983, W984, W985, W986, W987, W988, W989, W990, W991, W992, W993, W994, W995, W996, W997, W998, W999, W1000 , W1001, W1002, W1003, W1004, W1005, W1006, W1007, W1008, W1009, W1010, W1011, W1012, W1013, W1014, W1015, W1016, W1017, W1018, W1019, W1020, W1021, W1022, W1023, W1024 , W1026, W1027, W1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W983, W984 and / or W992, W993 and / or W1005, W1006 and / or W1012, W1013 and / or W1021, W1022 may each be taken together to form a "heterocyclyl";
(H) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1029, -NW1030W1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1032, -C (O) O-W1033, -C (O) NH-W1034, -C (O) NW1035W1036, -O-W1037, -O (-W1038-O) _i -H (i = 1, 2, 3, 4, 5), -O (-W1039-O) _i -W1040 (i = 1, 2, 3, 4, 5), -OC (O) -W1041, -OC (O) -O-W1042, -OC (O) -NHW1043, -O-C (O)- NW1044W1045, -OP (O) (OW1046) (OW1047), -OSi (W1048) (W1049) (W1050), -OS (O ₂ ) -W1051, -NHC (O) -W1052, -NW1053C (O) -W1054, -NH-C (O) -O-W1055, -NH-C (O) -NH-W1056, -NH-C (O ) -NW1057W1058, -NW1059-C (O) -O-W1060, -NW1061-C (O) -NH-W1062, -NW1063-C (O) -NW1064W1065, -NHS (O ₂ ) -W1066, -NW1067S (O ₂ ) -W1068, -S-W1069, -S (O) -W1070, -S (O ₂ ) -W1071, -S (O ₂ ) NH-W1072, -S (O ₂ ) NW1073W1074, -S (O ₂ ) O-W1075, -P (O) (OW1076) (OW1077), -Si (W1078) (W1079) (W1080) ";
At that time, W1029, W1030, W1031, W1032, W1033, W1034, W1035, W1036, W1037, W1038, W1039, W1040, W1041, W1042, W1043, W1044, W1045, W1046, W1047, W1048, W1049, W1050, W1051, W1052, . , W1078, W1079, W1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1035, W1036 and / or W1044, W1045 and / or W1057, W1058 and / or W1064, W1065 and / or W1073, W1074 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1081, -NW1082W1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1084, -C (O) O-W1085, -C (O) NH-W1086, -C (O) NW1087W1088, -O-W1089, -O (-W1090-O) _j -H (j = 1, 2, 3, 4, 5), -O (-W1091-O) _j -W1092 (j = 1, 2, 3, 4, 5), -OC (O) -W1093, -OC (O) -O-W1094, -OC (O) -NHW1095, -O-C (O)- NW1096W1097, -OP (O) (OW1098) (OW1099), -OSi (W1100) (W1101) (W1102), -OS (O ₂ ) -W1103, -NHC (O) -W1104, -NW1105C (O) -W1106, -NH-C (O) -O-W1107, -NH-C (O) -NH-W1108, -NH-C (O ) -NW1109W1110, -NW1111-C (O) -O-W1112, -NW1113-C (O) -NH-W1114, -NW1115-C (O) -NW1116W1117, -NHS (O ₂ ) -W1118, -NW1119S (O ₂ ) -W1120, -S-W1121, -S (O) -W1122, -S (O ₂ ) -W1123, -S (O ₂ ) NH-W1124, -S (O ₂ ) NW1125W1126, -S (O ₂ ) O-W1127, -P (O) (OW1128) (OW1129), -Si (W1130) (W1131) (W1132) ";
At that time, W1081, W1082, W1083, W1084, W1085, W1086, W1087, W1088, W1089, W1090, W1091, W1092, W1093, W1094, W1095, W1096, W1097, W1098, W1099, W1100, W1101, W1102, W1103, W1104 W1105, W1106, W1107, W1108, W1109, W1110, W1111, W1112, W1113, W1114, W1115, W1116, W1117, W1118, W1119, W1120, W1121, W1122, W1123, W1124, W1125, W1126, W1127, W1128, W1127, W1128 , W1130, W1131, W1132, independently of one another, are “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1087, W1088 and / or W1096, W1097 and / or W1109, W1110 and / or W1116, W1117 and / or W1125, W1126 may each be taken together to form a “heterocyclyl”;
(J) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -W1133, -C (O) O-W1134, -C (O)- NW1135W1136, -S (O ₂ ) -W1137, -S (O ₂ ) O-W1138 ";
In this case, W1133, W1134, W1135, W1136, W1137, and W1138 are independent of each other as “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, W1135, W1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1139, -NW1140W1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1142, -C (O) O-W1143, -C (O) NH-W1144, -C (O) NW1145W1146, -O-W1147, -O (-W1148-O) _k -H (k = 1, 2, 3, 4, 5), -O (-W1149-O) _k -W1150 (k = 1, 2, 3, 4, 5), -OC (O) -W1151, -OC (O) -O-W1152, -OC (O) -NHW1153, -O-C (O)- NW1154W1155, -OP (O) (OW1156) (OW1157), -OSi (W1158) (W1159) (W1160), -OS (O ₂ ) -W1161, -NHC (O) -W1162, -NW1163C (O) -W1164, -NH-C (O) -O-W1165, -NH-C (O) -NH-W1166, -NH-C (O ) -NW1167W1168, -NW1169-C (O) -O-W1170, -NW1171-C (O) -NH-W1172, -NW1173-C (O) -NW1174W1175, -NHS (O ₂ ) -W1176, -NW1177S (O ₂ ) -W1178, -S-W1179, -S (O) -W1180, -S (O ₂ ) -W1181, -S (O ₂ ) NH-W1182, -S (O ₂ ) NW1183W1184, -S (O ₂ ) O-W1185, -P (O) (OW1186) (OW1187), -Si (W1188) (W1189) (W1190) ";
In that case, W1139, W1140, W1141, W1142, W1143, W1144, W1145, W1146, W1147, W1148, W1149, W1150, W1151, W1152, W1153, W1154, W1155, W1156, W1157, W1158, W1159, W1160, W1161, W1162 W1163, W1164, W1165, W1166, W1167, W1168, W1169, W1170, W1171, W1172, W1173, W1174, W1175, W1176, W1177, W1178, W1179, W1180, W1181, W1182, W1183, W1184, W1185, W1186, W1185, W1186 , W1188, W1189, W1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1145, W1146 and / or W1154, W1155 and / or W 1167, W 1168 and / or W 1174, W 1175 and / or W 1183, W 1184 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1191, -NW1192W1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1194, -C (O) O-W1195, -C (O) NH-W1196, -C (O) NW1197W1198, -O-W1199, -O (-W1200-O). _l -H (l = 1, 2, 3, 4, 5), -O (-W1201-O) _l -W1202 (l = 1, 2, 3, 4, 5), -OC (O) -W1203, -OC (O) -O-W1204, -OC (O) -NHW1205, -O-C (O)- NW1206W1207, -OP (O) (OW1208) (OW1209), -OSi (W1210) (W1211) (W1212), -OS (O ₂ ) -W1213, -NHC (O) -W1214, -NW1215C (O) -W1216, -NH-C (O) -O-W1217, -NH-C (O) -NH-W1218, -NH-C (O ) -NW1219W1220, -NW1221-C (O) -O-W1222, -NW1223-C (O) -NH-W1224, -NW1225-C (O) -NW1226W1227, -NHS (O ₂ ) -W1228, -NW1229S (O ₂ ) -W1230, -S-W1231, -S (O) -W1232, -S (O ₂ ) -W1233, -S (O ₂ ) NH-W1234, -S (O ₂ ) NW1235W1236, -S (O ₂ ) O-W1237, -P (O) (OW1238) (OW1239), -Si (W1240) (W1241) (W1242) ";
At that time, W1191, W1192, W1193, W1194, W1195, W1196, W1197, W1198, W1199, W1200, W1201, W1202, W1203, W1204, W1205, W1206, W1207, W1208, W1209, W1210, W1211, W1212, W1212, W1212 W1215, W1216, W1217, W1218, W1219, W1220, W1221, W1222, W1223, W1224, W1225, W1226, W1227, W1228, W1229, W1230, W1231, W1232, W1233, W1234, W1235, W1236, W1237, W1238 , W1240, W1241, W1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1197, W1198 and / or W1206, W1207 and / or W1219, W1220 and / or W1226, W1227 and / or W1235, W1236 may each be taken together to form a “heterocyclyl”;
Or
(D)
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are selected from the group consisting of:
(1) "-NZ10Z11, -OZ12, -SZ13";
In this case, one or both groups Z10, Z11 and groups Z12, Z13 of the groups Z10, Z11 are selected, independently of one another, from the group consisting of:
(A) "hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl";
Provided that both groups Z10, Z11 are not simultaneously hydrogen;
In addition, however, the group Z12 is not hydrogen;
Provided that the substituent of the substituent group (a) is further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other, when not being hydrogen. Is:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N _Three , -NH-cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NQ1Q2, -S- Cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -O-cycloalkyl , -O-cycloalkylalkyl, -O-arylalkyl, -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclyl, -O-heterocyclylalkyl, -O (-Q3-O) _p -Q4 (p = 1, 2, 3, 4, 5), -O (-Q5-O) _p -H (p = 1, 2, 3, 4, 5), -OP (O) (OQ6) (OQ7), -C (O) O-Q8, -C (O) NH ₂ , -C (O) NH-Q9, -C (O) NQ10Q11, -S (O ₂ ) -Q12, -P (O) (OH) ₂ , -P (O) (OQ13) (OQ14), -Si (Q15) (Q16) (Q17), -O-Si (Q18) (Q19) (Q20), -O-C (O) -O-Q21 , -O-C (O) -NH-Q22, -O-C (O) -NQ23Q24, -NH-C (O) -O-Q25, -NH-C (O) -NH-Q26, -NH- C (O) -NQ27Q28, -NQ29-C (O) -O-Q30, -NQ31-C (O) -NH-Q32, -NQ33-C (O) -NQ34Q35, -NQ36-S (O ₂ ) -Q37, -NH-S (O ₂ ) -Q38, -O-S (O ₂ ) -Q39, -NH-C (O) -Q40, -NQ41-C (O) -Q42, -C (O) -Q43, -OC (O) -Q44, -S (O) -Q45, -S (O ₂ ) -NHQ46, -S (O ₂ ) -NQ47Q48, -S (O ₂ ) -OQ49 ";
However, in addition, “—N (alkyl) ₂ "Is further substituted with at least one substituent selected from the following substituent group (ii);
At that time, Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8, Q9, Q10, Q11, Q12, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q20, Q21, Q22, Q23, Q24 Q25, Q26, Q27, Q28, Q29, Q30, Q31, Q32, Q33, Q34, Q35, Q36, Q37, Q38, Q39, Q40, Q41, Q42, Q43, Q44, Q45, Q46, Q47, Q48, Q49 Are independent of each other, "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from Q10, Q11 and / or Q23, Q24 and / or Or Q27, Q28 and / or Q34, Q35 and / or Q47, Q48 may each be taken together to form a "heterocyclyl";
In that case, depending on the circumstances, the substituents of the substituent group (a) and / or the substituent group (i), independently of one another, are the same or different and are selected from the group consisting of: It may be further substituted by a group:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ50, -NQ51Q52, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q53, -C (O) O-Q54, -C (O) NH-Q55, -C (O) NQ56Q57, -O-Q58, -O (-Q59-O) _r -H (r = 1, 2, 3, 4, 5), -O (-Q60-O) _r -Q61 (r = 1, 2, 3, 4, 5), -OC (O) -Q62, -OC (O) -O-Q63, -OC (O) -NHQ64, -O-C (O)- NQ65Q66, -OP (O) (OQ67) (OQ68), -OSi (Q69) (Q70) (Q71), -OS (O ₂ ) -Q72, -NHC (O) -Q73, -NQ74C (O) -Q75, -NH-C (O) -O-Q76, -NH-C (O) -NH-Q77, -NH-C (O ) -NQ78Q79, -NQ80-C (O) -O-Q81, -NQ82-C (O) -NH-Q83, -NQ84-C (O) -NQ85Q86, -NHS (O ₂ ) -Q87, -NQ88S (O ₂ ) -Q89, -S-Q90, -S (O) -Q91, -S (O ₂ ) -Q92, -S (O ₂ ) NH-Q93, -S (O ₂ ) NQ94Q95, -S (O ₂ ) O-Q96, -P (O) (OQ97) (OQ98), -Si (Q99) (Q100) (Q101) ";
At that time, Q50, Q52, Q53, Q54, Q55, Q56, Q57, Q58, Q59, Q60, Q61, Q62, Q63, Q64, Q65, Q66, Q67, Q68, Q69, Q70, Q71, Q72, Q73, Q74 Q75, Q76, Q77, Q78, Q79, Q80, Q81, Q82, Q83, Q84, Q85, Q86, Q87, Q88, Q89, Q90, Q91, Q92, Q93, Q94, Q95, Q96, Q97, Q98, Q99 , Q100 and Q101 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q56, Q57 and / or Q65, Q66 and / or Q78, Q79 and / or Q85, Q86 and / or Q94, Q95 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ102, -NQ103Q104, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q105, -C (O) O-Q106, -C (O) NH-Q107, -C (O) NQ108Q109, -O-Q110, -O (-Q111-O) _s -H (s = 1, 2, 3, 4, 5), -O (-Q112-O) _s -Q113 (s = 1, 2, 3, 4, 5), -OC (O) -Q114, -OC (O) -O-Q115, -OC (O) -NHQ116, -O-C (O)- NQ117Q118, -OP (O) (OQ119) (OQ120), -OSi (Q121) (Q122) (Q123), -OS (O ₂ ) -Q124, -NHC (O) -Q125, -NQ126C (O) -Q127, -NH-C (O) -O-Q128, -NH-C (O) -NH-Q129, -NH-C (O ) -NQ130Q131, -NQ132-C (O) -O-Q133, -NQ134-C (O) -NH-Q135, -NQ136-C (O) -NQ137Q138, -NHS (O ₂ ) -Q139, -NQ140S (O ₂ ) -Q141, -S-Q142, -S (O) -Q143, -S (O ₂ ) -Q144, -S (O ₂ ) NH-Q145, -S (O ₂ ) NQ146Q147, -S (O ₂ ) O-Q148, -P (O) (OQ149) (OQ150), -Si (Q152) (Q152) (Q153) ";
At that time, Q102, Q103, Q104, Q105, Q106, Q107, Q108, Q109, Q110, Q111, Q112, Q113, Q114, Q115, Q116, Q117, Q118, Q119, Q120, Q121, Q122, Q123, Q124, Q125 Q126, Q127, Q128, Q129, Q130, Q131, Q132, Q133, Q134, Q135, Q136, Q137, Q138, Q139, Q140, Q141, Q142, Q143, Q144, Q145, Q146, Q147, Q148, Q149, Q150 , Q151, Q152, Q153 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q108, Q109 and / or Q117, Q118 and / or Q130, Q131 and / or Q137, Q138 and / or Q146, Q147 may each be taken together to form a “heterocyclyl”;
(B) "C ₉ ~ C ₃₀ -Alkyl, -C (O) -Q154, -C (O) O-Q155, -C (O) -NQ156Q157, -S (O ₂ ) -Q158, -S (O ₂ ) O-Q159 ";
In this case, Q154, Q155, Q156, Q157, Q158, and Q159 are independent of each other as “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, Q156, Q157 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (b) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ160, -NQ161Q162, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q163, -C (O) O-Q164, -C (O) NH-Q165, -C (O) NQ166Q167, -O-Q168, -O (-Q169-O) _t -H (t = 1, 2, 3, 4, 5), -O (-Q170-O) _t -Q171 (t = 1, 2, 3, 4, 5), -OC (O) -Q172, -OC (O) -O-Q173, -OC (O) -NHQ174, -O-C (O)- NQ175Q176, -OP (O) (OQ177) (OQ178), -OSi (Q179) (Q180) (Q181), -OS (O ₂ ) -Q182, -NHC (O) -Q183, -NQ184C (O) -Q185, -NH-C (O) -O-Q186, -NH-C (O) -NH-Q187, -NH-C (O ) -NQ188Q189, -NQ190-C (O) -O-Q191, -NQ192-C (O) -NH-Q193, -NQ194-C (O) -NQ195Q196, -NHS (O ₂ ) -Q197, -NQ198S (O ₂ ) -Q199, -S-Q200, -S (O) -Q201, -S (O ₂ ) -Q202, -S (O ₂ ) NH-Q203, -S (O ₂ ) NQ204Q205, -S (O ₂ ) O-Q206, -P (O) (OQ207) (OQ208), -Si (Q209) (Q210) (Q211) ";
At that time, Q160, Q161, Q162, Q163, Q164, Q165, Q166, Q167, Q168, Q169, Q170, Q171, Q172, Q173, Q174, Q175, Q176, Q177, Q178, Q179, Q180, Q181, Q182, Q183 Q184, Q185, Q186, Q187, Q188, Q189, Q190, Q191, Q192, Q193, Q194, Q195, Q196, Q197, Q198, Q199, Q200, Q201, Q202, Q203, Q204, Q205, Q206, Q207, Q208 , Q209, Q210, Q211 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q166, Q167 and / or Q175, Q176 and / or Q188, Q189 and / or Q195, Q196 and / or Q204, Q205 can be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ212, -NQ213Q214, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q215, -C (O) O-Q216, -C (O) NH-Q217, -C (O) NQ218Q219, -O-Q220, -O (-Q221-O) _u -H (u = 1, 2, 3, 4, 5), -O (-Q222-O) _u -Q223 (u = 1, 2, 3, 4, 5), -OC (O) -Q224, -OC (O) -O-Q225, -OC (O) -NHQ226, -O-C (O)- NQ227Q228, -OP (O) (OQ229) (OQ230), -OSi (Q231) (Q232) (Q233), -OS (O ₂ ) -Q234, -NHC (O) -Q235, -NQ236C (O) -Q237, -NH-C (O) -O-Q238, -NH-C (O) -NH-Q239, -NH-C (O ) -NQ240Q241, -NQ242-C (O) -O-Q243, -NQ244-C (O) -NH-Q245, -NQ246-C (O) -NQ247Q248, -NHS (O ₂ ) -Q249, -NQ250S (O ₂ ) -Q251, -S-Q252, -S (O) -Q253, -S (O ₂ ) -Q254, -S (O ₂ ) NH-Q255, -S (O ₂ ) NQ256Q257, -S (O ₂ ) O-Q258, -P (O) (OQ259) (OQ260), -Si (Q261) (Q262) (Q263) ";
At that time, Q212, Q213, Q214, Q215, Q216, Q217, Q218, Q219, Q220, Q221, Q222, Q223, Q224, Q225, Q226, Q227, Q228, Q229, Q230, Q231, Q232, Q233, Q234, Q235 Q236, Q237, Q238, Q239, Q240, Q241, Q242, Q243, Q244, Q245, Q246, Q247, Q248, Q249, Q250, Q251, Q252, Q253, Q254, Q255, Q256, Q257, Q258, Q259, 260 , Q261, Q262, Q263 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from Q218, Q219 and / or Q227, Q228 and / Or Q240, Q241 and / or Q247, Q248 and / or Q256, Q257 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ264, -NQ265Q266, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q267, -C (O) O-Q268, -C (O) NH-Q269, -C (O) NQ270Q271, -O-Q272, -O (-Q273-O) _v -H (v = 1, 2, 3, 4, 5), -O (-Q274-O) _v -Q275 (v = 1, 2, 3, 4, 5), -OC (O) -Q276, -OC (O) -O-Q277, -OC (O) -NHQ278, -O-C (O)- NQ279Q280, -OP (O) (OQ281) (OQ282), -OSi (Q283) (Q284) (Q285), -OS (O ₂ ) -Q286, -NHC (O) -Q287, -NQ288C (O) -Q289, -NH-C (O) -O-Q290, -NH-C (O) -NH-Q291, -NH-C (O ) -NQ292Q293, -NQ294-C (O) -O-Q295, -NQ296-C (O) -NH-Q297, -NQ298-C (O) -NQ299Q300, -NHS (O ₂ ) -Q301, -NQ302S (O ₂ ) -Q303, -S-Q304, -S (O) -Q305, -S (O ₂ ) -Q306, -S (O ₂ ) NH-Q307, -S (O ₂ ) NQ308Q309, -S (O ₂ ) O-Q310, -P (O) (OQ311) (OQ312), -Si (Q313) (Q314) (Q315) ";
At that time, Q264, Q265, Q266, Q267, Q268, Q269, Q270, Q271, Q272, Q273, Q274, Q275, Q276, Q277, Q278, Q279, Q280, Q281, Q282, Q283, Q284, Q286, Q287 Q288, Q289, Q290, Q291, Q292, Q293, Q294, Q295, Q296, Q297, Q298, Q299, Q300, Q301, Q302, Q303, Q304, Q305, Q306, Q307, Q308, Q309, Q310, Q311, Q312 , Q313, Q314, and Q315 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q270, Q271 and / or Q279, Q289 and / or Q292, Q293 and / or Q299, Q300 and / or Q308, Q309 can each be taken together to form a “heterocyclyl”;
as well as
One of the groups Z10, Z11 is, independently of one another, selected from the group consisting of: or neither of the groups Z10, Z11 is selected from the group consisting of:
(C) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -C (O) -Q316, -C (O) O-Q317, -C (O)- NQ318Q319, -S (O ₂ ) -Q320, -S (O ₂ ) O-Q321 ";
At that time, Q316, Q317, Q318, Q319, Q320, and Q321 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, Q318, Q319 together are" Heterocyclyl "can also be formed;
In this case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ322, -NQ323Q324, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q325, -C (O) O-Q326, -C (O) NH-Q327, -C (O) NQ328Q329, -O-Q330, -O (-Q331-O) _w -H (w = 1, 2, 3, 4, 5), -O (-Q332-O) _w -Q333 (w = 1, 2, 3, 4, 5), -OC (O) -Q334, -OC (O) -O-Q335, -OC (O) -NHQ336, -O-C (O)- NQ337Q338, -OP (O) (OQ339) (OQ340), -OSi (Q341) (Q342) (Q343), -OS (O ₂ ) -Q344, -NHC (O) -Q345, -NQ346C (O) -Q347, -NH-C (O) -O-Q348, -NH-C (O) -NH-Q349, -NH-C (O ) -NQ350Q351, -NQ352-C (O) -O-Q353, -NQ354-C (O) -NH-Q355, -NQ356-C (O) -NQ357Q358, -NHS (O ₂ ) -Q359, -NQ360S (O ₂ ) -Q361, -S-Q362, -S (O) -Q363, -S (O ₂ ) -Q364, -S (O ₂ ) NH-Q365, -S (O ₂ ) NQ366Q367, -S (O ₂ ) O-Q368, -P (O) (OQ369) (OQ370), -Si (Q371) (Q372) (Q373) ";
At that time, Q322, Q323, Q324, Q325, Q326, Q327, Q328, Q329, Q330, Q331, Q332, Q333, Q334, Q335, Q336, Q337, Q338, Q339, Q340, Q341, Q342, Q343, Q344, Q345 Q346, Q347, Q348, Q349, Q350, Q351, Q352, Q353, Q354, Q355, Q356, Q357, Q358, Q359, Q360, Q361, Q362, Q363, Q364, Q365, Q366, Q367, Q368, Q369 , Q371, Q372 and Q373 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q328, Q329 and / or Q337, Q338 and / or Q350, Q351 and / or Q357, Q358 and / or Q366, Q367 may be taken together to form a “heterocyclyl”;
In that case, the said substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other;
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ374, -NQ375Q376, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q377, -C (O) O-Q378, -C (O) NH-Q379, -C (O) NQ380Q381, -O-Q382, -O (-Q383-O) _x -H (x = 1, 2, 3, 4, 5), -O (-Q384-O) _x -Q385 (x = 1, 2, 3, 4, 5), -OC (O) -Q386, -OC (O) -O-Q387, -OC (O) -NHQ388, -O-C (O)- NQ389Q390, -OP (O) (OQ391) (OQ392), -OSi (Q393) (Q394) (Q395), -OS (O ₂ ) -Q396, -NHC (O) -Q397, -NQ398C (O) -Q399, -NH-C (O) -O-Q400, -NH-C (O) -NH-Q401, -NH-C (O ) -NQ402Q403, -NQ404-C (O) -O-Q405, -NQ406-C (O) -NH-Q407, -NQ408-C (O) -NQ409Q410, -NHS (O ₂ ) -Q411, -NQ412S (O ₂ ) -Q413, -S-Q414, -S (O) -Q415, -S (O ₂ ) -Q416, -S (O ₂ ) NH-Q417, -S (O ₂ ) NQ418Q419, -S (O ₂ ) O-Q420, -P (O) (OQ421) (OQ422), -Si (Q423) (Q424) (Q425) ";
At that time, Q374, Q375, Q376, Q377, Q378, Q379, Q380, Q381, Q382, Q383, Q384, Q385, Q386, Q387, Q388, Q389, Q390, Q391, Q392, Q393, Q394, Q395, Q395, Q395 Q398, Q399, Q400, Q401, Q402, Q403, Q404, Q405, Q406, Q407, Q408, Q409, Q410, Q411, Q412, Q413, Q414, Q415, Q416, Q417, Q418, Q419, Q420, Q421, Q422 , Q423, Q424, Q425 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q380, Q381 and / or Q389, Q390 and / or Q402, Q403 and / or Q409, Q410 and / or Q418, Q419 may be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ426, -NQ427Q428, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q429, -C (O) O-Q430, -C (O) NH-Q431, -C (O) NQ432Q433, -O-Q434, -O (-Q435-O) _y -H (y = 1, 2, 3, 4, 5), -O (-Q436-O) _y -Q437 (y = 1, 2, 3, 4, 5), -OC (O) -Q438, -OC (O) -O-Q439, -OC (O) -NHQ440, -O-C (O)- NQ441Q442, -OP (O) (OQ443) (OQ444), -OSi (Q445) (Q446) (Q447), -OS (O ₂ ) -Q448, -NHC (O) -Q449, -NQ450C (O) -Q451, -NH-C (O) -O-Q452, -NH-C (O) -NH-Q453, -NH-C (O ) -NQ454Q455, -NQ456a-C (O) -O-Q456b, -NQ456c-C (O) -NH-Q456d, -NQ456e-C (O) -NQ456fQ456g, -NHS (O ₂ ) -Q456h, -NQ456iS (O ₂ ) -Q456j, -S-Q456k, -S (O) -Q456l, -S (O ₂ ) -Q456m, -S (O ₂ ) NH-Q456n, -S (O ₂ ) NQ456oQ456p, -S (O ₂ ) O-Q456q, -P (O) (OQ456r) (OQ456s), -Si (Q456t) (Q456u) (Q456v) ";
At that time, Q426, Q427, Q428, Q429, Q430, Q431, Q432, Q433, Q434, Q435, Q436, Q437, Q438, Q439, Q440, Q441, Q442, Q443, Q444, Q445, Q446a, Q446a, Q446c, Q446c Q446e, Q446f, Q446g, Q446h, Q446i, Q446j, Q446k, Q446l, Q446m, Q446n, Q446o, Q446p, Q446q, Q446r, Q446s, Q446t, Q446u, Q446v are independent of each other. ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q432, Q433 and / or Q441, Q442 and / or Q454, Q455 and / or Q456f, Q456g and / or Q456o, Q456p can be taken together to form a "heterocyclyl";
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(D) hydrogen;
(E) halogen, F, Cl, Br, I;
(F) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ457, -NQ458Q459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q460, -C (O) O-Q461, -C (O) NH-Q462, -C (O) NQ463Q464, -O-Q465, -O (-Q466-O) _z -H (z = 1, 2, 3, 4, 5), -O (-Q467-O) _z -Q468 (z = 1, 2, 3, 4, 5), -OC (O) -Q469, -OC (O) -O-Q470, -OC (O) -NHQ471, -O-C (O)- NQ472Q473, -OP (O) (OQ474) (OQ475), -OSi (Q476) (Q477) (Q478), -OS (O ₂ ) -Q479, -NHC (O) -Q480, -NQ481C (O) -Q482, -NH-C (O) -O-Q483, -NH-C (O) -NH-Q484, -NH-C (O ) -NQ485Q486, -NQ487-C (O) -O-Q488, -NQ489-C (O) -NH-Q490, -NQ491-C (O) -NQ492Q493, -NHS (O ₂ ) -Q494, -NQ495S (O ₂ ) -Q496, -S-Q497, -S (O) -Q498, -S (O ₂ ) -Q499, -S (O ₂ ) NH-Q500, -S (O ₂ ) NQ501Q502, -S (O ₂ ) O-Q503, -P (O) (OQ504) (OQ505), -Si (Q506) (Q507) (Q508) ";
At that time, Q457, Q458, Q459, Q460, Q461, Q462, Q463, Q464, Q465, Q466, Q467, Q468, Q469, Q470, Q471, Q472, Q473, Q474, Q475, Q476, Q477, Q478, Q480 Q481, Q482, Q483, Q484, Q485, Q486, Q487, Q488, Q489, Q490, Q491, Q492, Q493, Q494, Q495, Q496, Q497, Q498, Q499, Q500, Q501, Q502, Q503, Q504 , Q506, Q507, Q508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q463, Q464 and / or Q472, Q473 and / or Q485, Q486 and / or Q492, Q493 and / or Q501, Q502 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ509, -NQ510Q511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q512, -C (O) O-Q513, -C (O) NH-Q514, -C (O) NQ515Q516, -O-Q517, -O (-Q518-O) _a -H (a = 1, 2, 3, 4, 5), -O (-Q519-O) _a -Q520 (a = 1, 2, 3, 4, 5), -OC (O) -Q521, -OC (O) -O-Q522, -OC (O) -NHQ523, -O-C (O)- NQ524Q525, -OP (O) (OQ526) (OQ527), -OSi (Q528) (Q529) (Q530), -OS (O ₂ ) -Q531, -NHC (O) -Q532, -NQ533C (O) -Q534, -NH-C (O) -O-Q535, -NH-C (O) -NH-Q536, -NH-C (O ) -NQ537Q538, -NQ539-C (O) -O-Q540, -NQ541-C (O) -NH-Q542, -NQ543-C (O) -NQ544Q545, -NHS (O ₂ ) -Q546, -NQ547S (O ₂ ) -Q548, -S-Q549, -S (O) -Q550, -S (O ₂ ) -Q551, -S (O ₂ ) NH-Q552, -S (O ₂ ) NQ553Q554, -S (O ₂ ) O-Q555, -P (O) (OQ556) (OQ557), -Si (Q558) (Q559) (Q560) ";
At that time, Q509, Q510, Q511, Q512, Q513, Q514, Q515, Q516, Q517, Q518, Q519, Q520, Q521, Q522, Q523, Q524, Q525, Q526, Q527, Q528, Q529, Q530, Q531, Q532 Q533, Q534, Q535, Q536, Q537, Q538, Q539, Q540, Q541, Q542, Q543, Q544, Q545, Q546, Q547, Q548, Q549, Q550, Q551, Q552, Q553, Q554, Q555, Q556 , Q558, Q559, Q560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q515, Q516 and / or Q524, Q525 and / or Q537, Q538 and / or Q544, Q545 and / or Q553, Q554 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ561, -NQ562Q563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q564, -C (O) O-Q565, -C (O) NH-Q566, -C (O) NQ567Q568, -O-Q569, -O (-Q570-O) _b -H (b = 1, 2, 3, 4, 5), -O (-Q571-O) _b -Q572 (b = 1, 2, 3, 4, 5), -OC (O) -Q573, -OC (O) -O-Q574, -OC (O) -NHQ575, -O-C (O)- NQ576Q577, -OP (O) (OQ578) (OQ579), -OSi (Q580) (Q581) (Q582), -OS (O ₂ ) -Q583, -NHC (O) -Q584, -NQ585C (O) -Q586, -NH-C (O) -O-Q587, -NH-C (O) -NH-Q588, -NH-C (O ) -NQ589Q590, -NQ591-C (O) -O-Q592, -NQ593-C (O) -NH-Q594, -NQ595-C (O) -NQ596Q597, -NHS (O ₂ ) -Q598, -NQ599S (O ₂ ) -Q600, -S-Q601, -S (O) -Q602, -S (O ₂ ) -Q603, -S (O ₂ ) NH-Q604, -S (O ₂ ) NQ605Q606, -S (O ₂ ) O-Q607, -P (O) (OQ608) (OQ609), -Si (Q610) (Q611) (Q612) ";
At that time, Q561, Q562, Q563, Q564, Q565, Q566, Q567, Q568, Q569, Q570, Q571, Q572, Q573, Q574, Q575, Q576, Q577, Q578, Q579, Q580, Q581, Q582, Q583 Q585, Q586, Q587, Q588, Q589, Q590, Q591, Q592, Q593, Q594, Q595, Q596, Q597, Q598, Q599, Q600, Q601, Q602, Q603, Q604, Q605, Q606, Q607, Q608 , Q610, Q611, Q612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q567, Q568 and / or Q576, Q577 and / or Q589, Q590 and / or Q596, Q597 and / or Q605, Q606 can each be taken together to form a "heterocyclyl";
(G) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ613, -NQ614Q615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q616, -C (O) O-Q617, -C (O) NH-Q618, -C (O) NQ619Q620, -O-Q621, -O (-Q622-O) _c -H (c = 1, 2, 3, 4, 5), -O (-Q623-O) _c -Q624 (c = 1, 2, 3, 4, 5), -OC (O) -Q625, -OC (O) -O-Q626, -OC (O) -NHQ627, -O-C (O)- NQ628Q629, -OP (O) (OQ630) (OQ631), -OSi (Q632) (Q633) (Q634), -OS (O ₂ ) -Q635, -NHC (O) -Q636, -NQ637C (O) -Q638, -NH-C (O) -O-Q639, -NH-C (O) -NH-Q640, -NH-C (O ) -NQ641Q642, -NQ643-C (O) -O-Q644, -NQ645-C (O) -NH-Q646, -NQ647-C (O) -NQ648Q649, -NHS (O ₂ ) -Q650, -NQ651S (O ₂ ) -Q652, -S-Q653, -S (O) -Q654, -S (O ₂ ) -Q655, -S (O ₂ ) NH-Q656, -S (O ₂ ) NQ657Q658, -S (O ₂ ) O-Q659, -P (O) (OQ660) (OQ661), -Si (Q662) (Q663) (Q664) ";
At that time, Q613, Q614, Q615, Q616, Q617, Q618, Q619, Q620, Q621, Q622, Q623, Q624, Q625, Q626, Q627, Q628, Q629, Q630, Q631, Q632, Q633, Q634, Q635, Q636 Q637, Q638, Q639, Q640, Q641, Q642, Q643, Q644, Q645, Q646, Q647, Q648, Q649, Q650, Q651, Q652, Q653, Q654, Q655, Q656, Q657, Q658, Q659, Q660 , Q662, Q663, Q664 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q619, Q620 and / or Q628, Q629 and / or Q641, Q642 and / or Q648, Q649 and / or Q657, Q658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ665, -NQ666Q667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q668, -C (O) O-Q669, -C (O) NH-Q670, -C (O) NQ671Q672, -O-Q673, -O (-Q674-O) _d -H (d = 1, 2, 3, 4, 5), -O (-Q675-O) _d -Q676 (d = 1, 2, 3, 4, 5), -OC (O) -Q677, -OC (O) -O-Q678, -OC (O) -NHQ679, -O-C (O)- NQ680Q681, -OP (O) (OQ682) (OQ683), -OSi (Q684) (Q685) (Q686), -OS (O ₂ ) -Q687, -NHC (O) -Q688, -NQ689C (O) -Q690, -NH-C (O) -O-Q691, -NH-C (O) -NH-Q692, -NH-C (O ) -NQ693Q694, -NQ695-C (O) -O-Q696, -NQ697-C (O) -NH-Q698, -NQ699-C (O) -NQ700Q701, -NHS (O ₂ ) -Q702, -NQ703S (O ₂ ) -Q704, -S-Q705, -S (O) -Q706, -S (O ₂ ) -Q707, -S (O ₂ ) NH-Q708, -S (O ₂ ) NQ709Q710, -S (O ₂ ) O-Q711, -P (O) (OQ712) (OQ713), -Si (Q714) (Q715) (Q716) ";
At that time, Q665, Q666, Q667, Q668, Q669, Q670, Q671, Q672, Q673, Q674, Q675, Q676, Q677, Q678, Q679, Q680, Q681, Q682, Q683, Q684, Q685, Q686, Q687 Q689, Q690, Q691, Q692, Q693, Q694, Q695, Q696, Q697, Q698, Q699, Q700, Q701, Q702, Q703, Q704, Q705, Q706, Q707, Q708, Q709, Q710, Q711, Q712, Q711 , Q714, Q715, Q716 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q671, Q672 and / or Q680, Q681 and / or Q693, Q694 and / or Q700, Q701 and / or Q709, Q710 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ717, -NQ718Q719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q720, -C (O) O-Q721, -C (O) NH-Q722, -C (O) NQ723Q724, -O-Q725, -O (-Q726-O) _e -H (e = 1, 2, 3, 4, 5), -O (-Q727-O) _e -Q728 (e = 1, 2, 3, 4, 5), -OC (O) -Q729, -OC (O) -O-Q730, -OC (O) -NHQ731, -O-C (O)- NQ732Q733, -OP (O) (OQ734) (OQ735), -OSi (Q736) (Q737) (Q738), -OS (O ₂ ) -Q739, -NHC (O) -Q740, -NQ741C (O) -Q742, -NH-C (O) -O-Q743, -NH-C (O) -NH-Q744, -NH-C (O ) -NQ745Q746, -NQ747-C (O) -O-Q748, -NQ749-C (O) -NH-Q750, -NQ751-C (O) -NQ752Q753, -NHS (O ₂ ) -Q754, -NQ755S (O ₂ ) -Q756, -S-Q757, -S (O) -Q758, -S (O ₂ ) -Q759, -S (O ₂ ) NH-Q760, -S (O ₂ ) NQ761Q762, -S (O ₂ ) O-Q763, -P (O) (OQ764) (OQ765), -Si (Q766) (Q767) (Q768) ";
At that time, Q717, Q718, Q719, Q720, Q721, Q722, Q723, Q724, Q725, Q726, Q727, Q728, Q729, Q730, Q731, Q732, Q733, Q734, Q735, Q736, Q737, Q738, Q739, Q7 Q741, Q742, Q743, Q744, Q745, Q746, Q747, Q748, Q749, Q750, Q751, Q752, Q753, Q754, Q755, Q756, Q757, Q758, Q759, Q760, Q761, Q762, Q763, 764 , Q766, Q767, Q768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q723, Q724 and / or Q732, Q733 and / or Q745, Q746 and / or Q752, Q753 and / or Q761, Q762 can each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ769, -NQ770Q771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q772, -C (O) O-Q773, -C (O) NH-Q774, -C (O) NQ775Q776, -O-Q777, -O (-Q778-O) _f -H (f = 1, 2, 3, 4, 5), -O (-Q779-O) _f -Q780 (f = 1, 2, 3, 4, 5), -OC (O) -Q781, -OC (O) -O-Q782, -OC (O) -NHQ783, -O-C (O)- NQ784Q785, -OP (O) (OQ786) (OQ787), -OSi (Q788) (Q789) (Q790), -OS (O ₂ ) -Q791, -NHC (O) -Q792, -NQ793C (O) -Q794, -NH-C (O) -O-Q795, -NH-C (O) -NH-Q796, -NH-C (O ) -NQ797Q798, -NQ799-C (O) -O-Q800, -NQ801-C (O) -NH-Q802, -NQ803-C (O) -NQ804Q805, -NHS (O ₂ ) -Q806, -NQ807S (O ₂ ) -Q808, -S-Q809, -S (O) -Q810, -S (O ₂ ) -Q811, -S (O ₂ ) NH-Q812, -S (O ₂ ) NQ813Q814, -S (O ₂ ) O-Q815, -P (O) (OQ816) (OQ817), -Si (Q818) (Q819) (Q820) ";
At that time, Q769, Q770, Q771, Q772, Q773, Q774, Q775, Q776, Q777, Q778, Q779, Q780, Q781, Q782, Q783, Q784, Q785, Q786, Q787, Q788, Q789, Q790, Q791, Q79 Q793, Q794, Q795, Q796, Q797, Q798, Q799, Q800, Q801, Q802, Q803, Q804, Q805, Q806, Q807, Q808, Q809, Q810, Q811, Q812, Q813, Q814, Q815, Q816 , Q818, Q819, Q820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q775, Q776 and / or Q784, Q785 and / or Q797, Q798 and / or Q804, Q805 and / or Q813, Q814 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ821, -NQ822Q823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q824, -C (O) O-Q825, -C (O) NH-Q826, -C (O) NQ827Q828, -O-Q829, -O (-Q830-O) _g -H (g = 1, 2, 3, 4, 5), -O (-Q831-O) _g -Q832 (g = 1, 2, 3, 4, 5), -OC (O) -Q833, -OC (O) -O-Q834, -OC (O) -NHQ835, -O-C (O)- NQ836Q837, -OP (O) (OQ838) (OQ839), -OSi (Q840) (Q841) (Q842), -OS (O ₂ ) -Q843, -NHC (O) -Q844, -NQ845C (O) -Q846, -NH-C (O) -O-Q847, -NH-C (O) -NH-Q848, -NH-C (O ) -NQ849Q850, -NQ851-C (O) -O-Q852, -NQ853-C (O) -NH-Q854, -NQ855-C (O) -NQ856Q857, -NHS (O ₂ ) -Q858, -NQ859S (O ₂ ) -Q860, -S-Q861, -S (O) -Q862, -S (O ₂ ) -Q863, -S (O ₂ ) NH-Q864, -S (O ₂ ) NQ865Q866, -S (O ₂ ) O-Q867, -P (O) (OQ868) (OQ869), -Si (Q870) (Q871) (Q872) ";
At that time, Q821, Q822, Q823, Q824, Q825, Q826, Q827, Q828, Q829, Q830, Q831, Q832, Q833, Q834, Q835, Q836, Q837, Q838, Q839, Q840, Q841, Q842, Q843 Q845, Q846, Q847, Q848, Q849, Q850, Q851, Q852, Q853, Q854, Q855, Q856, Q857, Q858, Q859, Q860, Q861, Q862, Q863, Q864, Q865, Q866, Q867, 86 , Q870, Q871, Q872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q827, Q828 and / or Q836, Q837 and / or Q849, Q850 and / or Q856, Q857 and / or Q865, Q866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ873, -NQ874Q875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q876, -C (O) O-Q877, -C (O) NH-Q878, -C (O) NQ879Q880, -O-Q881, -O (-Q882-O) _h -H (h = 1, 2, 3, 4, 5), -O (-Q883-O) _h -Q884 (h = 1, 2, 3, 4, 5), -OC (O) -Q885, -OC (O) -O-Q886, -OC (O) -NHQ887, -O-C (O)- NQ888Q889, -OP (O) (OQ890) (OQ891), -OSi (Q892) (Q893) (Q894), -OS (O ₂ ) -Q895, -NHC (O) -Q896, -NQ897C (O) -Q898, -NH-C (O) -O-Q899, -NH-C (O) -NH-Q900, -NH-C (O ) -NQ901Q902, -NQ903-C (O) -O-Q904, -NQ905-C (O) -NH-Q906, -NQ907-C (O) -NQ908Q909, -NHS (O ₂ ) -Q910, -NQ911S (O ₂ ) -Q912, -S-Q913, -S (O) -Q914, -S (O ₂ ) -Q915, -S (O ₂ ) NH-Q916, -S (O ₂ ) NQ917Q918, -S (O ₂ ) O-Q919, -P (O) (OQ920) (OQ921), -Si (Q922) (Q923) (Q924) ";
At that time, Q873, Q874, Q875, Q876, Q877, Q878, Q879, Q880, Q881, Q882, Q883, Q884, Q885, Q886, Q887, Q888, Q889, Q890, Q891, Q892, Q893, Q894, Q895 Q897, Q898, Q899, Q900, Q901, Q902, Q903, Q904, Q905, Q906, Q907, Q908, Q909, Q910, Q911, Q912, Q913, Q914, Q915, Q916, Q917, Q918, Q919, Q920 , Q922, Q923, Q924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q879, Q880 and / or Q888, Q889 and / or Q901, Q902 and / or Q908, Q909 and / or Q917, Q918 can each be taken together to form a "heterocyclyl";
(J) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ925, -NQ926Q927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q928, -C (O) O-Q929, -C (O) NH-Q930, -C (O) NQ931Q932, -O-Q933, -O (-Q934-O) _i -H (i = 1, 2, 3, 4, 5), -O (-Q935-O) _i -Q936 (i = 1, 2, 3, 4, 5), -OC (O) -Q937, -OC (O) -O-Q938, -OC (O) -NHQ939, -O-C (O)- NQ940Q941, -OP (O) (OQ942) (OQ943), -OSi (Q944) (Q945) (Q946), -OS (O ₂ ) -Q947, -NHC (O) -Q948, -NQ949C (O) -Q950, -NH-C (O) -O-Q951, -NH-C (O) -NH-Q952, -NH-C (O ) -NQ953Q954, -NQ955-C (O) -O-Q956, -NQ957-C (O) -NH-Q958, -NQ959-C (O) -NQ960Q961, -NHS (O ₂ ) -Q962, -NQ963S (O ₂ ) -Q964, -S-Q965, -S (O) -Q966, -S (O ₂ ) -Q967, -S (O ₂ ) NH-Q968, -S (O ₂ ) NQ969Q970, -S (O ₂ ) O-Q971, -P (O) (OQ972) (OQ973), -Si (Q974) (Q975) (Q976) ";
At that time, Q925, Q926, Q927, Q928, Q929, Q930, Q931, Q932, Q933, Q934, Q935, Q936, Q937, Q938, Q939, Q940, Q941, Q942, Q943, Q944, Q945, Q946, Q947, Q948 Q949, Q950, Q951, Q952, Q953, Q954, Q955, Q956, Q957, Q958, Q959, Q960, Q961, Q962, Q963, Q964, Q965, Q966, Q967, Q968, Q969, Q970, Q971, Q972 , Q974, Q975, Q976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q931, Q932 and / or Q940, Q941 and / or Q953, Q954 and / or Q960, Q961 and / or Q969, Q970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ977, -NQ978Q979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q980, -C (O) O-Q981, -C (O) NH-Q982, -C (O) NQ983Q984, -O-Q985, -O (-Q986-O) _j -H (j = 1, 2, 3, 4, 5), -O (-Q987-O) _j -Q988 (j = 1, 2, 3, 4, 5), -OC (O) -Q989, -OC (O) -O-Q990, -OC (O) -NHQ991, -O-C (O)- NQ992Q993, -OP (O) (OQ994) (OQ995), -OSi (Q996) (Q997) (Q998), -OS (O ₂ ) -Q999, -NHC (O) -Q1000, -NQ1001C (O) -Q1002, -NH-C (O) -O-Q1003, -NH-C (O) -NH-Q1004, -NH-C (O ) -NQ1005Q1006, -NQ1007-C (O) -O-Q1008, -NQ1009-C (O) -NH-Q1010, -NQ1011-C (O) -NQ1012Q1013, -NHS (O ₂ ) -Q1014, -NQ1015S (O ₂ ) -Q1016, -S-Q1017, -S (O) -Q1018, -S (O ₂ ) -Q1019, -S (O ₂ ) NH-Q1020, -S (O ₂ ) NQ1021Q1022, -S (O ₂ ) O-Q1023, -P (O) (OQ1024) (OQ1025), -Si (Q1026) (Q1027) (Q1028) ";
At that time, Q977, Q978, Q979, Q980, Q981, Q982, Q983, Q984, Q985, Q986, Q987, Q988, Q989, Q990, Q991, Q992, Q993, Q994, Q995, Q996, Q997, Q998, 1000 Q1001, Q1002, Q1003, Q1004, Q1005, Q1006, Q1007, Q1008, Q1009, Q1010, Q1011, Q1012, Q1013, Q1014, Q1015, Q1016, Q1017, Q1018, Q1019, Q1020, Q1021, Q1022, Q1023, Q1024 , Q1026, Q1027, Q1028 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q983, Q984 and / or Q992, Q993 and / or Q1005, Q1006 and / or Q1012, Q1013 and / or Q1021, Q1022 can each be taken together to form a "heterocyclyl";
(K) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1029, -NQ1030Q1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1032, -C (O) O-Q1033, -C (O) NH-Q1034, -C (O) NQ1035Q1036, -O-Q1037, -O (-Q1038-O) _k -H (k = 1, 2, 3, 4, 5), -O (-Q1039-O) _k -Q1040 (k = 1, 2, 3, 4, 5), -OC (O) -Q1041, -OC (O) -O-Q1042, -OC (O) -NHQ1043, -O-C (O)- NQ1044Q1045, -OP (O) (OQ1046) (OQ1047), -OSi (Q1048) (Q1049) (Q1050), -OS (O ₂ ) -Q1051, -NHC (O) -Q1052, -NQ1053C (O) -Q1054, -NH-C (O) -O-Q1055, -NH-C (O) -NH-Q1056, -NH-C (O ) -NQ1057Q1058, -NQ1059-C (O) -O-Q1060, -NQ1061-C (O) -NH-Q1062, -NQ1063-C (O) -NQ1064Q1065, -NHS (O ₂ ) -Q1066, -NQ1067S (O ₂ ) -Q1068, -S-Q1069, -S (O) -Q1070, -S (O ₂ ) -Q1071, -S (O ₂ ) NH-Q1072, -S (O ₂ ) NQ1073Q1074, -S (O ₂ ) O-Q1075, -P (O) (OQ1076) (OQ1077), -Si (Q1078) (Q1079) (Q1080) ";
At that time, Q1029, Q1030, Q1031, Q1032, Q1033, Q1034, Q1035, Q1036, Q1037, Q1038, Q1039, Q1040, Q1041, Q1042, Q1043, Q1044, Q1045, Q1046, Q1047, Q1048, Q1049, Q1050, Q1051, Q105 Q1053, Q1054, Q1055, Q1056, Q1057, Q1058, Q1059, Q1060, Q1061, Q1062, Q1063, Q1064, Q1065, Q1066, Q1067, Q1068, Q1069, Q1070, Q1071, Q1072, Q1073, Q1074, Q1075, Q1076 , Q1078, Q1079, Q1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1035, Q1036 and / or Q1044, Q1045 and / or Q1057, Q1058 and / or Q1064, Q1065 and / or Q1073, Q1074 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1081, -NQ1082Q1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1084, -C (O) O-Q1085, -C (O) NH-Q1086, -C (O) NQ1087Q1088, -O-Q1089, -O (-Q1090-O) _l -H (l = 1, 2, 3, 4, 5), -O (-Q1091-O) _l -Q1092 (l = 1, 2, 3, 4, 5), -OC (O) -Q1093, -OC (O) -O-Q1094, -OC (O) -NHQ1095, -O-C (O)- NQ1096Q1097, -OP (O) (OQ1098) (OQ1099), -OSi (Q1100) (Q1101) (Q1102), -OS (O ₂ ) -Q1103, -NHC (O) -Q1104, -NQ1105C (O) -Q1106, -NH-C (O) -O-Q1107, -NH-C (O) -NH-Q1108, -NH-C (O ) -NQ1109Q1110, -NQ1111-C (O) -O-Q1112, -NQ1113-C (O) -NH-Q1114, -NQ1115-C (O) -NQ1116Q1117, -NHS (O ₂ ) -Q1118, -NQ1119S (O ₂ ) -Q1120, -S-Q1121, -S (O) -Q1122, -S (O ₂ ) -Q1123, -S (O ₂ ) NH-Q1124, -S (O ₂ ) NQ1125Q1126, -S (O ₂ ) O-Q1127, -P (O) (OQ1128) (OQ1129), -Si (Q1130) (Q1131) (Q1132) ";
At that time, Q1081, Q1082, Q1083, Q1084, Q1085, Q1086, Q1087, Q1088, Q1089, Q1090, Q1091, Q1092, Q1093, Q1094, Q1095, Q1096, Q1097, Q1098, Q1099, Q1100, Q1101, Q1102, Q1103, Q1104 Q1105, Q1106, Q1107, Q1108, Q1109, Q1110, Q1111, Q1112, Q1113, Q1114, Q1115, Q1116, Q1117, Q1118, Q1119, Q1120, Q1121, Q1122, Q1123, Q1124, Q1125, Q1126, Q1127, Q1128 , Q1130, Q1131, and Q1132 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1087, Q1088 and / or Q1096, Q1097 and / or Q1109, Q1110 and / or Q1116, Q1117 and / or Q1125, Q1126 can each be taken together to form a "heterocyclyl";
(L) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -Q1133, -C (O) O-Q1134, -C (O)- NQ1135Q1136, -S (O ₂ ) -Q1137, -S (O ₂ ) O-Q1138 ";
In this case, Q1133, Q1134, Q1135, Q1136, Q1137, and Q1138 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, Q1135, Q1136 taken together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1139, -NQ1140Q1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1142, -C (O) O-Q1143, -C (O) NH-Q1144, -C (O) NQ1145Q1146, -O-Q1147, -O (-Q1148-O) _m -H (m = 1, 2, 3, 4, 5), -O (-Q1149-O) _m -Q1150 (m = 1, 2, 3, 4, 5), -OC (O) -Q1151, -OC (O) -O-Q1152, -OC (O) -NHQ1153, -O-C (O)- NQ1154Q1155, -OP (O) (OQ1156) (OQ1157), -OSi (Q1158) (Q1159) (Q1160), -OS (O ₂ ) -Q1161, -NHC (O) -Q1162, -NQ1163C (O) -Q1164, -NH-C (O) -O-Q1165, -NH-C (O) -NH-Q1166, -NH-C (O ) -NQ1167Q1168, -NQ1169-C (O) -O-Q1170, -NQ1171-C (O) -NH-Q1172, -NQ1173-C (O) -NQ1174Q1175, -NHS (O ₂ ) -Q1176, -NQ1177S (O ₂ ) -Q1178, -S-Q1179, -S (O) -Q1180, -S (O ₂ ) -Q1181, -S (O ₂ ) NH-Q1182, -S (O ₂ ) NQ1183Q1184, -S (O ₂ ) O-Q1185, -P (O) (OQ1186) (OQ1187), -Si (Q1188) (Q1189) (Q1190) ";
At that time, Q1139, Q1140, Q1141, Q1142, Q1143, Q1144, Q1145, Q1146, Q1147, Q1148, Q1149, Q1150, Q1151, Q1152, Q1153, Q1154, Q1155, Q1156, Q1157, Q1158, Q1159, Q1160, Q1161, Q2 Q1163, Q1164, Q1165, Q1166, Q1167, Q1168, Q1169, Q1170, Q1171, Q1172, Q1173, Q1174, Q1175, Q1176, Q1177, Q1178, Q1179, Q1180, Q1181, Q1182, Q1183, Q1184, Q1185, Q1186, Q1185, Q1186 , Q1188, Q1189, Q1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1145, Q1146 and / or Q1154, Q1155 and / or Q1167, Q1168 and / or Q1174, Q1175 and / or Q1183, Q1184 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1191, -NQ1192Q1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1194, -C (O) O-Q1195, -C (O) NH-Q1196, -C (O) NQ1197Q1198, -O-Q1199, -O (-Q1200-O) _n -H (n = 1, 2, 3, 4, 5), -O (-Q1201-O) _n -Q1202 (n = 1, 2, 3, 4, 5), -OC (O) -Q1203, -OC (O) -O-Q1204, -OC (O) -NHQ1205, -O-C (O)- NQ1206Q1207, -OP (O) (OQ1208) (OQ1209), -OSi (Q1210) (Q1211) (Q1212), -OS (O ₂ ) -Q1213, -NHC (O) -Q1214, -NQ1215C (O) -Q1216, -NH-C (O) -O-Q1217, -NH-C (O) -NH-Q1218, -NH-C (O ) -NQ1219Q1220, -NQ1221-C (O) -O-Q1222, -NQ1223-C (O) -NH-Q1224, -NQ1225-C (O) -NQ1226Q1227, -NHS (O ₂ ) -Q1228, -NQ1229S (O ₂ ) -Q1230, -S-Q1231, -S (O) -Q1232, -S (O ₂ ) -Q1233, -S (O ₂ ) NH-Q1234, -S (O ₂ ) NQ1235Q1236, -S (O ₂ ) O-Q1237, -P (O) (OQ1238) (OQ1239), -Si (Q1240) (Q1241) (Q1242) ";
At that time, Q1191, Q1192, Q1193, Q1194, Q1195, Q1196, Q1197, Q1198, Q1199, Q1200, Q1201, Q1202, Q1203, Q1204, Q1205, Q1206, Q1207, Q1208, Q1209, Q1210, Q1211, Q1212, Q1213, Q12 Q1215, Q1216, Q1217, Q1218, Q1219, Q1220, Q1221, Q1222, Q1223, Q1224, Q1225, Q1226, Q1227, Q1228, Q1229, Q1230, Q1231, Q1232, Q1233, Q1234, Q1235, Q1236, Q1237, 3938 , Q1240, Q1241, Q1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1197, Q1198 and / or Q1206, Q1207 and / or Q1219, Q1220 and / or Q1226, Q1227 and / or Q1235, Q1236 can each be taken together to form a “heterocyclyl”;
as well as
The radicals Z1, Z2 are independently selected from the group consisting of “hydrogen, NZ14Z15”;
However, when Z1 = 1, Z2 = NZ14Z15 and when Z1 = NZ14Z15, Z2 = H;
Z14 and Z15 are then selected from the group consisting of:
(A) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (Y1) NZ16Z17, -C (= NZ18) -Z19, -C (Y2) NZ20- Y3-Z21 ";
However, Z14 and Z15 are simultaneously hydrogen or “alkyl, C ₉ ~ C ₃₀ -Not "alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl";
However, in addition, one of the groups Z14, Z15 is hydrogen or "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ", wherein the other group Z14, Z15 is" -C (Y1) NZ16Z17 "," -C (= NZ18) -Z19 "or" -C (Y2) NZ20-Y3-Z21 ";
Y1, Y2, Y3 are then selected from the group consisting of “O, S, ═NH, ═NZ22” independently of each other;
In so doing, Z16, Z17, Z18, Z19, Z20, Z21, Z22 are independently selected from the group consisting of:
(1) hydrogen;
(2) "Alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl ";
In this case, the substituents of the substituent group (a) and / or the substituent group (2) are at least one substituent selected from the group consisting of the following, independently of each other, and optionally the same or different: May be substituted by a group:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU1, -NU2U3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U4, -C (O) O-U5, -C (O) NH-U6, -C (O) NU7U8, -O-U9, -O (-U10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-U11-O) _r -U12 (r = 1, 2, 3, 4, 5), -OC (O) -U13, -OC (O) -O-U14, -OC (O) -NHU15, -O-C (O)- NU16U17, -OP (O) (OU18) (OU19), -OSi (U20) (U21) (U22), -OS (O ₂ ) -U23, -NHC (O) -U24, -NU25C (O) -U26, -NH-C (O) -O-U27, -NH-C (O) -NH-U28, -NH-C (O ) -NU29U30, -NU31-C (O) -O-U32, -NU33-C (O) -NH-U34, -NU35-C (O) -NU36U37, -NHS (O ₂ ) -U38, -NU39S (O ₂ ) -U40, -S-U41, -S (O) -U42, -S (O ₂ ) -U43, -S (O ₂ ) NH-U44, -S (O ₂ ) NU45U46, -S (O ₂ ) O-U47, -P (O) (OU48) (OU49), -Si (U50) (U51) (U52) ";
At that time, U1, U2, U3, U4, U5, U6, U7, U8, U9, U10, U11, U12, U13, U14, U15, U16, U17, U18, U19, U20, U21, U22, U23, U24 U25, U26, U27, U28, U29, U30, U31, U32, U33, U34, U35, U36, U37, U38, U39, U40, U41, U42, U43, U44, U45, U46, U47, U48, U49 , U50, U51, U52 are independent of each other, "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U7, U8 and / or U16, U17 and / or U29, U30 and / or U36, U37 and / or U45, U46 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU53, -NU54U55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U56, -C (O) O-U57, -C (O) NH-U58, -C (O) NU59U60, -O-U61, -O (-U62-O) _r -H (r = 1, 2, 3, 4, 5), -O (-U63-O) _r -U64 (r = 1, 2, 3, 4, 5), -OC (O) -U65, -OC (O) -O-U66, -OC (O) -NHU67, -O-C (O)- NU68U69, -OP (O) (OU70) (OU71), -OSi (U72) (U73) (U74), -OS (O ₂ ) -U75, -NHC (O) -U76, -NU77C (O) -U78, -NH-C (O) -O-U79, -NH-C (O) -NH-U80, -NH-C (O ) -NU81U82, -NU83-C (O) -O-U84, -NU85-C (O) -NH-U86, -NU87-C (O) -NU88U89, -NHS (O ₂ ) -U90, -NU91S (O ₂ ) -U92, -S-U93, -S (O) -U94, -S (O ₂ ) -U95, -S (O ₂ ) NH-U96, -S (O ₂ ) NU97U98, -S (O ₂ ) O-U99, -P (O) (OU100) (OU101), -Si (U102) (U103) (U104) ";
At that time, U53, U54, U55, U56, U57, U58, U59, U60, U61, U62, U63, U64, U65, U66, U67, U68, U69, U70, U71, U72, U73, U74, U75, U76 U77, U78, U79, U80, U81, U82, U83, U84, U85, U86, U87, U88, U89, U90, U91, U92, U93, U94, U95, U96, U97, U98, U99, U100, U101 , U102, U103, U104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U59, U60 and / or U68, U69 and / or U81, U82 and / or U88, U89 and / or U97, U98 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU105, -NU106U107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U108, -C (O) O-U109, -C (O) NH-U110, -C (O) NU111U112, -O-U113, -O (-U114-O) _s -H (s = 1, 2, 3, 4, 5), -O (-U115-O) _s -U116 (s = 1, 2, 3, 4, 5), -OC (O) -U117, -OC (O) -O-U118, -OC (O) -NHU119, -O-C (O)- NU120U121, -OP (O) (OU122) (OU123), -OSi (U124) (U125) (U126), -OS (O ₂ ) -U127, -NHC (O) -U128, -NU129C (O) -U130, -NH-C (O) -O-U131, -NH-C (O) -NH-U132, -NH-C (O ) -NU133U134, -NU135-C (O) -O-U136, -NU137-C (O) -NH-U138, -NU139-C (O) -NU140U141, -NHS (O ₂ ) -U142, -NU143S (O ₂ ) -U144, -S-U145, -S (O) -U146, -S (O ₂ ) -U147, -S (O ₂ ) NH-U148, -S (O ₂ ) NU149U150, -S (O ₂ ) O-U151, -P (O) (OU152) (OU153), -Si (U154) (U155) (U156) ";
At that time, U105, U106, U107, U108, U109, U110, U111, U112, U113, U114, U115, U116, U117, U118, U119, U120, U121, U122, U123, U124, U125, U126, U127, U128 , U129, U130, U131, U132, U133, U134, U135, U136, U137, U138, U139, U140, U141, U142, U143, U144, U145, U146, U147, U148, U149, U150, U151, U152, U153 , U154, U155, U156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U111, U112 and / or U120, U121 and / or U133, U134 and / or U140, U141 and / or U149, U150 may each be taken together to form a "heterocyclyl";
(3) -C (O) -Z23,
Z23 is then independently selected from the group consisting of:
(A) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (a) may be substituted by at least one substituent selected from the group consisting of the following, independently or optionally, the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU157, -NU158U159, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U160, -C (O) O-U161, -C (O) NH-U162, -C (O) NU163U164, -O-U165, -O (-U166-O) _t -H (t = 1, 2, 3, 4, 5), -O (-U167-O) _t -U168 (t = 1, 2, 3, 4, 5), -OC (O) -U169, -OC (O) -O-U170, -OC (O) -NHU171, -O-C (O)- NU172U173, -OP (O) (OU174) (OU175), -OSi (U176) (U177) (U178), -OS (O ₂ ) -U179, -NHC (O) -U180, -NU181C (O) -U182, -NH-C (O) -O-U183, -NH-C (O) -NH-U184, -NH-C (O ) -NU185U186, -NU187-C (O) -O-U188, -NU189-C (O) -NH-U190, -NU191-C (O) -NU192U193, -NHS (O ₂ ) -U194, -NU195S (O ₂ ) -U196, -S-U197, -S (O) -U198, -S (O ₂ ) -U199, -S (O ₂ ) NH-U200, -S (O ₂ ) NU201U202, -S (O ₂ ) O-U203, -P (O) (OU204) (OU205), -Si (U206) (U207) (U208) ";
At that time, U157, U158, U159, U160, U161, U162, U163, U164, U165, U166, U167, U168, U169, U170, U171, U172, U173, U174, U175, U176, U177, U178, U179, U180 U181, U182, U183, U184, U185, U186, U187, U188, U189, U190, U191, U192, U193, U194, U195, U196, U197, U198, U199, U200, U201, U202, U203, U204, U205 , U206, U207, U208 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U163, U164 and / or U172, U173 and / or U185, U186 and / or U192, U193 and / or U201, U202 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU209, -NU210U211, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U212, -C (O) O-U213, -C (O) NH-U214, -C (O) NU215U216, -O-U217, -O (-U218-O) _u -H (u = 1, 2, 3, 4, 5), -O (-U219-O) _u -U220 (u = 1, 2, 3, 4, 5), -OC (O) -U221, -OC (O) -O-U222, -OC (O) -NHU223, -O-C (O)- NU224U225, -OP (O) (OU226) (OU227), -OSi (U228) (U229) (U230), -OS (O ₂ ) -U231, -NHC (O) -U232, -NU233C (O) -U234, -NH-C (O) -O-U235, -NH-C (O) -NH-U236, -NH-C (O ) -NU237U238, -NU239-C (O) -O-U240, -NU241-C (O) -NH-U242, -NU243-C (O) -NU244U245, -NHS (O ₂ ) -U246, -NU247S (O ₂ ) -U248, -S-U249, -S (O) -U250, -S (O ₂ ) -U251, -S (O ₂ ) NH-U252, -S (O ₂ ) NU253U254, -S (O ₂ ) O-U255, -P (O) (OU256) (OU257), -Si (U258) (U259) (U260) ";
At that time, U209, U210, U211, U212, U213, U214, U215, U216, U217, U218, U219, U220, U221, U222, U223, U224, U225, U226, U227, U228, U229, U230, U231, U232 , U233, U234, U235, U236, U237, U238, U239, U240, U241, U242, U243, U244, U245, U246, U247, U248, U249, U250, U251, U252, U253, U254, U255, U256, U255 , U258, U259, U260 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U215, U216 and / or U224, U225 and / or U237, U238 and / or U244, U245 and / or U253, U254 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU261, -NU262U263, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U264, -C (O) O-U265, -C (O) NH-U266, -C (O) NU267U268, -O-U269, -O (-U270-O) _v -H (v = 1, 2, 3, 4, 5), -O (-U271-O) _v -U272 (v = 1, 2, 3, 4, 5), -OC (O) -U273, -OC (O) -O-U274, -OC (O) -NHU275, -O-C (O)- NU276U277, -OP (O) (OU278) (OU279), -OSi (U280) (U281) (U282), -OS (O ₂ ) -U283, -NHC (O) -U284, -NU285C (O) -U286, -NH-C (O) -O-U287, -NH-C (O) -NH-U288, -NH-C (O ) -NU289U290, -NU291-C (O) -O-U292, -NU293-C (O) -NH-U294, -NU295-C (O) -NU296U297, -NHS (O ₂ ) -U298, -NU299S (O ₂ ) -U300, -S-U301, -S (O) -U302, -S (O ₂ ) -U303, -S (O ₂ ) NH-U304, -S (O ₂ ) NU305U306, -S (O ₂ ) O-U307, -P (O) (OU308) (OU309), -Si (U310) (U311) (U312) ";
At that time, U261, U262, U263, U264, U265, U266, U267, U268, U269, U270, U271, U272, U273, U274, U275, U276, U277, U278, U279, U280, U281, U282, U283, U284 , U285, U286, U287, U288, U289, U290, U291, U292, U293, U294, U295, U296, U297, U298, U299, U300, U301, U302, U303, U304, U305, U306, U307, U308, U309 , U310, U311 and U312 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U267, U268 and / or U276, U277 and / or U289, U290 and / or U296, U297 and / or U305, U306 may each be taken together to form a “heterocyclyl”;
(4) Z16, Z17 can be optionally joined together to form "heterocyclyl";
(5) "-C (O) -C (O) -U313, -S (O ₂ ) -NU314U315 ";
U313, U314, and U315 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU316, -NU317U318, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U319, -C (O) O-U320, -C (O) NH-U321, -C (O) NU322U323, -O-U324, -O (-U325-O) _w -H (w = 1, 2, 3, 4, 5), -O (-U326-O) _w -U327 (w = 1, 2, 3, 4, 5), -OC (O) -U328, -OC (O) -O-U329, -OC (O) -NHU330, -O-C (O)- NU331U332, -OP (O) (OU333) (OU334), -OSi (U335) (U336) (U337), -OS (O ₂ ) -U338, -NHC (O) -U339, -NU340C (O) -U341, -NH-C (O) -O-U342, -NH-C (O) -NH-U343, -NH-C (O ) -NU344U345, -NU346-C (O) -O-U347, -NU348-C (O) -NH-U349, -NU350-C (O) -NU351U352, -NHS (O ₂ ) -U353, -NU354S (O ₂ ) -U355, -S-U356, -S (O) -U357, -S (O ₂ ) -U358, -S (O ₂ ) NH-U359, -S (O ₂ ) NU360U361, -S (O ₂ ) O-U362, -P (O) (OU363) (OU364), -Si (U365) (U366) (U367) ";
At that time, U316, U317, U318, U319, U320, U321, U322, U323, U324, U325, U326, U327, U328, U329, U330, U331, U332, U333, U334, U335, U336, U337, U338, U339 U340, U341, U342, U343, U344, U345, U346, U347, U348, U349, U350, U351, U352, U353, U354, U355, U356, U357, U358, U359, U360, U361, U362, U363 , U365, U366, U367 are independently of each other "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U322, U323 and / or U331, U332 and / or U344, U345 and / or U351, U352 and / or U360, U361 may each be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU368, -NU369U370, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U371, -C (O) O-U372, -C (O) NH-U373, -C (O) NU374U375, -O-U376, -O (-U377-O) _x -H (x = 1, 2, 3, 4, 5), -O (-U378-O) _x -U379 (x = 1, 2, 3, 4, 5), -OC (O) -U380, -OC (O) -O-U381, -OC (O) -NHU382, -O-C (O)- NU383U384, -OP (O) (OU385) (OU386), -OSi (U387) (U388) (U389), -OS (O ₂ ) -U390, -NHC (O) -U391, -NU392C (O) -U393, -NH-C (O) -O-U394, -NH-C (O) -NH-U395, -NH-C (O ) -NU396U397, -NU398-C (O) -O-U399, -NU400-C (O) -NH-U401, -NU402-C (O) -NU403U404, -NHS (O ₂ ) -U405, -NU406S (O ₂ ) -U407, -S-U408, -S (O) -U409, -S (O ₂ ) -U410, -S (O ₂ ) NH-U411, -S (O ₂ ) NU412U413, -S (O ₂ ) O-U414, -P (O) (OU415) (OU416), -Si (U417) (U418) (U419) ";
At that time, U368, U369, U370, U371, U372, U373, U374, U375, U376, U377, U378, U379, U380, U381, U382, U383, U384, U385, U386, U387, U388, U389, U390, U39 , U392, U393, U394, U395, U396, U397, U398, U399, U400, U401, U402, U403, U404, U405, U406, U407, U408, U409, U410, U411, U412, U413, U414, U415, U416 , U417, U418, U419 are independently of each other "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U374, U375 and / or U383, U384 and / or U396, U397 and / or U403, U404 and / or U412, U413 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU420, -NU421U422, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U423, -C (O) O-U424, -C (O) NH-U425, -C (O) NU426U427, -O-U428, -O (-U429-O) _y -H (y = 1, 2, 3, 4, 5), -O (-U430-O) _y -U431 (y = 1, 2, 3, 4, 5), -OC (O) -U432, -OC (O) -O-U433, -OC (O) -NHU434, -O-C (O)- NU435U436, -OP (O) (OU437) (OU438), -OSi (U439) (U440) (U441), -OS (O ₂ ) -U442, -NHC (O) -U443, -NU444C (O) -U445, -NH-C (O) -O-U446, -NH-C (O) -NH-U447, -NH-C (O ) -NU448U449, -NU450-C (O) -O-U451, -NU452-C (O) -NH-U453, -NU454-C (O) -NU455U456, -NHS (O ₂ ) -U457, -NU458S (O ₂ ) -U459, -S-U460, -S (O) -U461, -S (O ₂ ) -U462, -S (O ₂ ) NH-U463, -S (O ₂ ) NU464U465, -S (O ₂ ) O-U466, -P (O) (OU467) (OU468), -Si (U469) (U470) (U471) ";
At that time, U420, U421, U422, U423, U424, U425, U426, U427, U428, U429, U430, U431, U432, U433, U434, U435, U436, U437, U438, U439, U440, U441, U442, U443 U444, U445, U446, U447, U448, U449, U450, U451, U452, U453, U454, U455, U456, U457, U458, U459, U460, U461, U462, U463, U464, U465, U466, U467 , U469, U470, U471 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U426, U427 and / or U435, U436 and / or U448, U449 and / or U455, U456 and / or U464, U465 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU472, -NU473U474, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U475, -C (O) O-U476, -C (O) NH-U477, -C (O) NU478U479, -O-U480, -O (-U481-O) _z -H (z = 1, 2, 3, 4, 5), -O (-U482-O) _z -U483 (z = 1, 2, 3, 4, 5), -OC (O) -U484, -OC (O) -O-U485, -OC (O) -NHU486, -O-C (O)- NU487U488, -OP (O) (OU489) (OU490), -OSi (U491) (U492) (U493), -OS (O ₂ ) -U494, -NHC (O) -U495, -NU496C (O) -U497, -NH-C (O) -O-U498, -NH-C (O) -NH-U499, -NH-C (O ) -NU500U501, -NU502-C (O) -O-U503, -NU504-C (O) -NH-U505, -NU506-C (O) -NU507U508, -NHS (O ₂ ) -U509, -NU510S (O ₂ ) -U511, -S-U512, -S (O) -U513, -S (O ₂ ) -U514, -S (O ₂ ) NH-U515, -S (O ₂ ) NU516U517, -S (O ₂ ) O-U518, -P (O) (OU519) (OU520), -Si (U521) (U522) (U523) ";
In that case, U472, U473, U474, U475, U476, U477, U478, U479, U480, U481, U482, U483, U484, U485, U486, U487, U488, U489, U490, U491, U492, U493, U494, U495 U496, U497, U498, U499, U500, U501, U502, U503, U504, U505, U506, U507, U508, U509, U510, U511, U512, U513, U514, U515, U516, U517, U518, U519, U520 , U521, U522, U523 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U478, U479 and / or U487, U488 and / or U500, U501 and / or U507, U508 and / or U516, U517 may each be taken together to form a "heterocyclyl";
In so doing, optionally U314, U315 may be taken together to form a "heterocyclyl";
as well as
The group Z5 is independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHA1, -NA2A3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -A4, -C (O) O-A5, -C (O) NH-A6, -C (O) NA7A8, -O-A9, -O (-A10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-A11-O) _r -A12 (r = 1, 2, 3, 4, 5), -OC (O) -A13, -OC (O) -O-A14, -OC (O) -NHA15, -O-C (O)- NA16A17, -OP (O) (OA18) (OA19), -OSi (A20) (A21) (A22), -OS (O ₂ ) -A23, -NHC (O) -A24, -NA25C (O) -A26, -NH-C (O) -O-A27, -NH-C (O) -NH-A28, -NH-C (O ) -NA29A30, -NA31-C (O) -O-A32, -NA33-C (O) -NH-A34, -NA35-C (O) -NA36A37, -NHS (O ₂ ) -A38, -NA39S (O ₂ ) -A40, -S-A41, -S (O) -A42, -S (O ₂ ) -A43, -S (O ₂ ) NH-A44, -S (O ₂ ) NA45A46, -S (O ₂ ) O-A47, -P (O) (OA48) (OA49), -Si (A50) (A51) (A52) ";
At that time, A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24 A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A47, A48, A49 , A50, A51, A52 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally A7, A8 and / or A16, A17 and / or A29, A30 and / or A36, A37 and / or A45, A46 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHA53, -NA54A55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -A56, -C (O) O-A57, -C (O) NH-A58, -C (O) NA59A60, -O-A61, -O (-A62-O) _s -H (s = 1, 2, 3, 4, 5), -O (-A63-O) _s -A64 (s = 1, 2, 3, 4, 5), -OC (O) -A65, -OC (O) -O-A66, -OC (O) -NHA67, -O-C (O)- NA68A69, -OP (O) (OA70) (OA71), -OSi (A72) (A73) (A74), -OS (O ₂ ) -A75, -NHC (O) -A76, -NA77C (O) -A78, -NH-C (O) -O-A79, -NH-C (O) -NH-A80, -NH-C (O ) -NA81A82, -NA83-C (O) -O-A84, -NA85-C (O) -NH-A86, -NA87-C (O) -NA88A89, -NHS (O ₂ ) -A90, -NA91S (O ₂ ) -A92, -S-A93, -S (O) -A94, -S (O ₂ ) -A95, -S (O ₂ ) NH-A96, -S (O ₂ ) NA97A98, -S (O ₂ ) O-A99, -P (O) (OA100) (OA101), -Si (A102) (A103) (A104) ";
At that time, A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, A65, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76 A77, A78, A79, A80, A81, A82, A83, A84, A85, A86, A87, A88, A89, A90, A91, A92, A93, A94, A95, A96, A97, A98, A99, A100, A101 , A102, A103, A104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally A59, A60 and / or A68, A69 and / or A81, A82 and / or A88, A89 and / or A97, A98 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHA105, -NA106A107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -A108, -C (O) O-A109, -C (O) NH-A110, -C (O) NA111A112, -O-A113, -O (-A114-O) _t -H (t = 1, 2, 3, 4, 5), -O (-A115-O) _t -A116 (t = 1, 2, 3, 4, 5), -OC (O) -A117, -OC (O) -O-A118, -OC (O) -NHA119, -O-C (O)- NA120A121, -OP (O) (OA122) (OA123), -OSi (A124) (A125) (A126), -OS (O ₂ ) -A127, -NHC (O) -A128, -NA129C (O) -A130, -NH-C (O) -O-A131, -NH-C (O) -NH-A132, -NH-C (O ) -NA133A134, -NA135-C (O) -O-A136, -NA137-C (O) -NH-A138, -NA139-C (O) -NA140A141, -NHS (O ₂ ) -A142, -NA143S (O ₂ ) -A144, -S-A145, -S (O) -A146, -S (O ₂ ) -A147, -S (O ₂ ) NH-A148, -S (O ₂ ) NA149A150, -S (O ₂ ) O-A151, -P (O) (OA152) (OA153), -Si (A154) (A155) (A156) ";
At that time, A105, A106, A107, A108, A109, A110, A111, A112, A113, A114, A115, A116, A117, A118, A119, A120, A121, A122, A123, A124, A125, A126, A127, A128 A129, A130, A131, A132, A133, A134, A135, A136, A137, A138, A139, A140, A141, A142, A143, A144, A145, A146, A147, A148, A149, A150, A151, A152, A153 , A154, A155, A156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally A111, A112 and / or A120, A121 and / or A133, A134 and / or A140, A141 and / or A149, A150 may each be taken together to form a "heterocyclyl";
Or
(E)
One or both radicals Z1, Z2 of the radicals Z1, Z2, independently of one another, are selected from the group consisting of:
(A) -NZ24Z25;
However, one or both groups Z24, Z25 of the groups Z24, Z25, independently of one another, are selected from the group consisting of:
(1) "-C (O) -C (O) -T1, -S (O ₂ ) -NT2T3 ";
T1, T2, T3 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT4, -NT5T6, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T7, -C (O) O-T8, -C (O) NH-T9, -C (O) NT10T11, -O-T12, -O (-T13-O) _p -H (p = 1, 2, 3, 4, 5), -O (-T14-O) _p -T15 (p = 1, 2, 3, 4, 5), -OC (O) -T16, -OC (O) -O-T17, -OC (O) -NHT18, -O-C (O)- NT19T20, -OP (O) (OT21) (OT22), -OSi (T23) (T24) (T25), -OS (O ₂ ) -T26, -NHC (O) -T27, -NT28C (O) -T29, -NH-C (O) -O-T30, -NH-C (O) -NH-T31, -NH-C (O ) -NT32T33, -NT34-C (O) -O-T35, -NT36-C (O) -NH-T37, -NT38-C (O) -NT39T40, -NHS (O ₂ ) -T41, -NT42S (O ₂ ) -T43, -S-T44, -S (O) -T45, -S (O ₂ ) -T46, -S (O ₂ ) NH-T47, -S (O ₂ ) NT48T49, -S (O ₂ ) O-T50, -P (O) (OT51) (OT52), -Si (T53) (T54) (T55) ";
At that time, T4, T5, T6, T7, T8, T9, T10, T11, T12, T13, T14, T15, T16, T17, T18, T19, T20, T21, T22, T23, T24, T25, T26, T27 T28, T29, T30, T31, T32, T33, T34, T35, T36, T37, T38, T39, T40, T41, T42, T43, T44, T45, T46, T47, T48, T49, T50, T51, T52 , T53, T54, T55 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T10, T11 and / or T19, T20 and / or T32, T33 and / or T39, T40 and / or T48, T49 may each be taken together to form a “heterocyclyl”;
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT56, -NT57T58, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T59, -C (O) O-T60, -C (O) NH-T61, -C (O) NT62T63, -O-T64, -O (-T65-O) _r -H (r = 1, 2, 3, 4, 5), -O (-T66-O) _r -T67 (r = 1, 2, 3, 4, 5), -OC (O) -T68, -OC (O) -O-T69, -OC (O) -NHT70, -O-C (O)- NT71T72, -OP (O) (OT73) (OT74), -OSi (T75) (T76) (T77), -OS (O ₂ ) -T78, -NHC (O) -T79, -NT80C (O) -T81, -NH-C (O) -O-T82, -NH-C (O) -NH-T83, -NH-C (O ) -NT84T85, -NT86-C (O) -O-T87, -NT88-C (O) -NH-T89, -NT90-C (O) -NT91T92, -NHS (O ₂ ) -T93, -NT94S (O ₂ ) -T95, -S-T96, -S (O) -T97, -S (O ₂ ) -T98, -S (O ₂ ) NH-T99, -S (O ₂ ) NT100T101, -S (O ₂ ) O-T102, -P (O) (OT103) (OT104), -Si (T105) (T106) (T107) ";
At that time, T56, T57, T58, T59, T60, T61, T62, T63, T64, T65, T66, T67, T68, T69, T70, T71, T72, T73, T74, T75, T76, T77, T78, T79 T80, T81, T82, T83, T84, T85, T86, T87, T88, T89, T90, T91, T92, T93, T94, T95, T96, T97, T98, T99, T100, T101, T102, T103, T104 , T105, T106, T107 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T62, T63 and / or T71, T72 and / or T84, T85 and / or T91, T92 and / or T100, T101 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT108, -NT109T110, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T111, -C (O) O-T112, -C (O) NH-T113, -C (O) NT114T115, -O-T116, -O (-T117-O) _s -H (s = 1, 2, 3, 4, 5), -O (-T118-O) _s -T119 (s = 1, 2, 3, 4, 5), -OC (O) -T120, -OC (O) -O-T121, -OC (O) -NHT122, -O-C (O)- NT123T124, -OP (O) (OT125) (OT126), -OSi (T127) (T128) (T129), -OS (O ₂ ) -T130, -NHC (O) -T131, -NT132C (O) -T133, -NH-C (O) -O-T134, -NH-C (O) -NH-T135, -NH-C (O ) -NT136T137, -NT138-C (O) -O-T139, -NT140-C (O) -NH-T141, -NT142-C (O) -NT143T144, -NHS (O ₂ ) -T145, -NT146S (O ₂ ) -T147, -S-T148, -S (O) -T149, -S (O ₂ ) -T150, -S (O ₂ ) NH-T151, -S (O ₂ ) NT152T153, -S (O ₂ ) O-T154, -P (O) (OT155) (OT156), -Si (T157) (T158) (T159) ";
At that time, T108, T109, T110, T111, T112, T113, T114, T115, T116, T117, T118, T119, T120, T121, T122, T123, T124, T125, T126, T127, T128, T129, T130, T131 , T132, T133, T134, T135, T136, T137, T138, T139, T140, T141, T142, T143, T144, T145, T146, T147, T148, T149, T150, T151, T152, T153, T154, T155, T156 , T157, T158, T159 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T114, T115 and / or T123, T124 and / or T136, T137 and / or T143, T144 and / or T152, T153 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT160, -NT161T162, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T163, -C (O) O-T164, -C (O) NH-T165, -C (O) NT166T167, -O-T168, -O (-T169-O) _t -H (t = 1, 2, 3, 4, 5), -O (-T170-O) _t -T171 (t = 1, 2, 3, 4, 5), -OC (O) -T172, -OC (O) -O-T173, -OC (O) -NHT174, -O-C (O)- NT175T176, -OP (O) (OT177) (OT178), -OSi (T179) (T180) (T181), -OS (O ₂ ) -T182, -NHC (O) -T183, -NT184C (O) -T185, -NH-C (O) -O-T186, -NH-C (O) -NH-T187, -NH-C (O ) -NT188T189, -NT190-C (O) -O-T191, -NT192-C (O) -NH-T193, -NT194-C (O) -NT195T196, -NHS (O ₂ ) -T197, -NT198S (O ₂ ) -T199, -S-T200, -S (O) -T201, -S (O ₂ ) -T202, -S (O ₂ ) NH-T203, -S (O ₂ ) NT204T205, -S (O ₂ ) O-T206, -P (O) (OT207) (OT208), -Si (T209) (T210) (T211) ";
At that time, T160, T161, T162, T163, T164, T165, T166, T167, T168, T169, T170, T171, T172, T173, T174, T175, T176, T177, T178, T179, T180, T181, T182, T183 T184, T185, T186, T187, T188, T189, T190, T191, T192, T193, T194, T195, T196, T197, T198, T199, T200, T201, T202, T203, T204, T205, T206, T207, T208 , T209, T210, T211 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T166, T167 and / or T175, T176 and / or T188, T189 and / or T195, T196 and / or T204, T205 may each be taken together to form a “heterocyclyl”;
In so doing, optionally, T2, T3 may be taken together to form "heterocyclyl";
as well as
One of the groups Z24, Z25, independently of one another, is selected from the group consisting of: or neither of the groups Z24, Z25 is selected from the group consisting of:
(2) "Hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In that case, depending on the case, the substituents of the substituent group (2) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT212, -NT213T214, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T215, -C (O) O-T216, -C (O) NH-T217, -C (O) NT218T219, -O-T220, -O (-T221-O) _u -H (u = 1, 2, 3, 4, 5), -O (-T222-O) _u -T223 (u = 1, 2, 3, 4, 5), -OC (O) -T224, -OC (O) -O-T225, -OC (O) -NHT226, -O-C (O)- NT227T228, -OP (O) (OT229) (OT230), -OSi (T231) (T232) (T233), -OS (O ₂ ) -T234, -NHC (O) -T235, -NT236C (O) -T237, -NH-C (O) -O-T238, -NH-C (O) -NH-T239, -NH-C (O ) -NT240T241, -NT242-C (O) -O-T243, -NT244-C (O) -NH-T245, -NT246-C (O) -NT247T248, -NHS (O ₂ ) -T249, -NT250S (O ₂ ) -T251, -S-T252, -S (O) -T253, -S (O ₂ ) -T254, -S (O ₂ ) NH-T255, -S (O ₂ ) NT256T257, -S (O ₂ ) O-T258, -P (O) (OT259) (OT260), -Si (T261) (T262) (T263) ";
At that time, T212, T213, T214, T215, T216, T217, T218, T219, T220, T221, T222, T223, T224, T225, T226, T227, T228, T229, T230, T231, T232, T233, T234, T235 , T236, T237, T238, T239, T240, T241, T242, T243, T244, T245, T246, T247, T248, T249, T250, T251, T252, T253, T254, T255, T256, T257, T258, T259, 260 , T261, T262, T263 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T218, T219 and / or T227, T228 and / or T240, T241 and / or T247, T248 and / or T256, T257 may be taken together to form a “heterocyclyl”;
In that case, the said substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other;
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT264, -NT265T266, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T267, -C (O) O-T268, -C (O) NH-T269, -C (O) NT270T271, -O-T272, -O (-T273-O) _v -H (v = 1, 2, 3, 4, 5), -O (-T274-O) _v -T275 (v = 1, 2, 3, 4, 5), -OC (O) -T276, -OC (O) -O-T277, -OC (O) -NHT278, -O-C (O)- NT279T280, -OP (O) (OT281) (OT282), -OSi (T283) (T284) (T285), -OS (O ₂ ) -T286, -NHC (O) -T287, -NT288C (O) -T289, -NH-C (O) -O-T290, -NH-C (O) -NH-T291, -NH-C (O ) -NT292T293, -NT294-C (O) -O-T295, -NT296-C (O) -NH-T297, -NT298-C (O) -NT299T300, -NHS (O ₂ ) -T301, -NT302S (O ₂ ) -T303, -S-T304, -S (O) -T305, -S (O ₂ ) -T306, -S (O ₂ ) NH-T307, -S (O ₂ ) NT308T309, -S (O ₂ ) O-T310, -P (O) (OT311) (OT312), -Si (T313) (T314) (T315) ";
At that time, T264, T265, T266, T267, T268, T269, T270, T271, T272, T273, T274, T275, T276, T277, T278, T279, T280, T281, T282, T283, T284, T285, T286, T287 T288, T289, T290, T291, T292, T293, T294, T295, T296, T297, T298, T299, T300, T301, T302, T303, T304, T305, T306, T307, T308, T309, T310, T311, T312 , T313, T314, T315 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T270, T271 and / or T279, T280 and / or T292, T293 and / or T299, T300 and / or T308, T309 may be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT316, -NT317T318, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T319, -C (O) O-T320, -C (O) NH-T321, -C (O) NT322T323, -O-T324, -O (-T325-O) _w -H (w = 1, 2, 3, 4, 5), -O (-T326-O) _w -T327 (w = 1, 2, 3, 4, 5), -OC (O) -T328, -OC (O) -O-T329, -OC (O) -NHT330, -O-C (O)- NT331T332, -OP (O) (OT333) (OT334), -OSi (T335) (T336) (T337), -OS (O ₂ ) -T338, -NHC (O) -T339, -NT340C (O) -T341, -NH-C (O) -O-T342, -NH-C (O) -NH-T343, -NH-C (O ) -NT344T345, -NT346-C (O) -O-T347, -NT348-C (O) -NH-T349, -NT350-C (O) -NT351T352, -NHS (O ₂ ) -T353, -NT354S (O ₂ ) -T355, -S-T356, -S (O) -T357, -S (O ₂ ) -T358, -S (O ₂ ) NH-T359, -S (O ₂ ) NT360T361, -S (O ₂ ) O-T362T, -P (O) (OT363) (OT364), -Si (T365) (T366) (T367) ";
At that time, T316, T317, T318, T319, T320, T321, T322, T323, T324, T325, T326, T327, T328, T329, T330, T331, T332, T333, T334, T335, T336, T337, T338, T339 , T340, T341, T342, T343, T344, T345, T346, T347, T348, T349, T350, T351, T352, T353, T354, T355, T356, T357, T358, T359, T360, T361, T362, T363 , T365, T366, T367 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T322, T323 and / or T331, T332 and / or T344, T345 and / or T351, T352 and / or T360, T361 can be taken together to form a “heterocyclyl”;
(B) -NZ26Z27,
In this case, one or both groups Z26, Z27 of the groups Z26, Z27 are selected independently of one another from the group consisting of:
(1) "-C (Y4) NZ28Z29, -C (= NZ30) -Z31";
Y4 is then selected from the group consisting of “O, S, ═NH, ═NZ32” independently of each other;
However, at least one of the groups Z28, Z29 and at least one of the groups Z30, Z31 are selected from the group consisting of:
(I) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl";
However, the said substituents of the substituent group (I) are further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, -NT368T369, -NHC (O) -cycloalkylalkyl, -NHC (O) -heterocyclylalkyl, -NT370C (O) -T371, -NH- C (O) -O-T372, -NH-C (O) -NH-T373, -NH-C (O) -NT374T375, -NT376-C (O) -O-T377, -NT378-C (O) -NH-T379, -NT380-C (O) -NT381T382, -NHS (O ₂ ) -Cycloalkylalkyl, -NHS (O ₂ ) -Heterocyclylalkyl, -NT383S (O ₂ ) -T384, -O-T385, -O (-T386-O) _x -T387 (x = 1, 2, 3, 4, 5), -O (-T388-O) _x -H (x = 1, 2, 3, 4, 5), -OC (O) -cycloalkylalkyl, -OC (O) -heterocyclylalkyl, -OC (O) -O-T389, -OC (O) -NHT390, -O-C (O) -NT391T392, -OS (O ₂ ) -Cycloalkylalkyl, -OS (O ₂ ) -Heterocyclylalkyl, -OP (O) (OT393) (OT394), -OSi (T395) (T396) (T397), -CHO, -C (O) -cycloalkyl, -C (O) -heterocyclyl,- C (O) -cycloalkylalkyl, -C (O) -heterocyclylalkyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -S-cycloalkylalkyl, -S-heterocyclylalkyl, -S-arylalkyl, -S-heteroarylalkyl, -S (O) -cycloalkyl, -S (O) -heterocyclyl, -S (O) -heteroaryl, -S (O) -cycloalkylalkyl,- S (O) -heterocyclylalkyl, -S (O) -arylalkyl, -S (O) -heteroarylalkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Heterocyclylalkyl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) NH-cycloalkyl, -S (O ₂ ) NH-heterocyclyl, -S (O ₂ ) NH-cycloalkylalkyl, -S (O ₂ ) NH-heterocyclylalkyl, -S (O ₂ ) NH-heteroarylalkyl, -S (O ₂ ) NT398T399, -S (O ₂ ) O-cycloalkyl, -S (O ₂ ) O-heterocyclyl, -S (O ₂ ) O-heteroaryl, -S (O ₂ ) O-cycloalkylalkyl, -S (O ₂ ) O-heterocyclylalkyl, -S (O ₂ ) O-heteroarylalkyl, -P (O) (OH) ₂ , -P (O) (OT400) (OT401), -Si (T402) (T403) (T404) ";
However, in addition, “—N (alkyl) ₂ ","-C (O) N (alkyl) ₂ ","-C (O) N (cycloalkyl) ₂ ","-C (O) N (aryl) ₂ ","-C (O) N (heteroaryl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (ii);
At that time, T368, T369, T370, T371, T372, T373, T374, T375, T376, T377, T378, T379, T380, T381, T382, T383, T384, T385, T386, T387, T388, T389, T390, T39 , T392, T393, T394, T395, T396, T397, T398, T399, T400, T401, T402, T403, T404 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T374, T375 and / or T381, T382 and / or T391, T392 and / or T398, T399 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT405, -NT406T407, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T408, -C (O) O-T409, -C (O) NH-T410, -C (O) NT411T412, -O-T413, -O (-T414-O) _y -H (y = 1, 2, 3, 4, 5), -O (-T415-O) _y -T416 (y = 1, 2, 3, 4, 5), -OC (O) -T417, -OC (O) -O-T418, -OC (O) -NHT419, -O-C (O)- NT420T421, -OP (O) (OT422) (OT423), -OSi (T424) (T425) (T426), -OS (O ₂ ) -T427, -NHC (O) -T428, -NT429C (O) -T430, -NH-C (O) -O-T431, -NH-C (O) -NH-T432, -NH-C (O ) -NT433T434, -NT435-C (O) -O-T436, -NT437-C (O) -NH-T438, -NT439-C (O) -NT440T441, -NHS (O ₂ ) -T442, -NT443S (O ₂ ) -T444, -S-T445, -S (O) -T446, -S (O ₂ ) -T447, -S (O ₂ ) NH-T448, -S (O ₂ ) NT449T450, -S (O ₂ ) O-T451, -P (O) (OT452) (OT453), -Si (T454) (T455) (T456) ";
At that time, T405, T406, T407, T408, T409, T410, T411, T412, T413, T414, T415, T416, T417, T418, T419, T420, T421, T422, T423, T424, T425, T426, T427, T428 , T429, T430, T431, T432, T433, T434, T435, T436, T437, T438, T439, T440, T441, T442, T443, T444, T445, T446, T447, T448, T449, T450, T451, T452 , T454, T455, T456 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T411, T412 and / or T420, T421 and / or T433, T434 and / or T440, T441 and / or T449, T450 can be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT457, -NT458T459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T460, -C (O) O-T461, -C (O) NH-T462, -C (O) NT463T464, -O-T465, -O (-T466-O) _z -H (z = 1, 2, 3, 4, 5), -O (-T467-O) _z -T468 (z = 1, 2, 3, 4, 5), -OC (O) -T469, -OC (O) -O-T470, -OC (O) -NHT471, -O-C (O)- NT472T473, -OP (O) (OT474) (OT475), -OSi (T476) (T477) (T478), -OS (O ₂ ) -T479, -NHC (O) -T480, -NT481C (O) -T482, -NH-C (O) -O-T483, -NH-C (O) -NH-T484, -NH-C (O ) -NT485T486, -NT487-C (O) -O-T488, -NT489-C (O) -NH-T490, -NT491-C (O) -NT492T493, -NHS (O ₂ ) -T494, -NT495S (O ₂ ) -T496, -S-T497, -S (O) -T498, -S (O ₂ ) -T499, -S (O ₂ ) NH-T500, -S (O ₂ ) NT501T502, -S (O ₂ ) O-T503, -P (O) (OT504) (OT505), -Si (T506) (T507) (T508) ";
At that time, T457, T458, T459, T460, T461, T462, T463, T464, T465, T466, T467, T468, T469, T470, T471, T472, T473, T474, T475, T476, T477, T478, T479, T479 , T481, T482, T483, T484, T485, T486, T487, T488, T489, T490, T491, T492, T493, T494, T495, T496, T497, T498, T499, T500, T501, T502, T503, T504 , T506, T507, T508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T463, T464 and / or T472, T473 and / or T485, T486 and / or T492, T493 and / or T501, T502 can each be taken together to form a "heterocyclyl";
Or
However, at least one of the groups Z28, Z29 and at least one of the groups Z30, Z31 are selected from the group consisting of:
(II) "C ₉ ~ C ₃₀ -Alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl,- C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In that case, in some cases, the substituents of the substituent group (II) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT509, -NT510T511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T512, -C (O) O-T513, -C (O) NH-T514, -C (O) NT515T516, -O-T517, -O (-T518-O) _r -H (a = 1, 2, 3, 4, 5), -O (-T519-O) _a -T520 (a = 1, 2, 3, 4, 5), -OC (O) -T521, -OC (O) -O-T522, -OC (O) -NHT523, -O-C (O)- NT524T525, -OP (O) (OT526) (OT527), -OSi (T528) (T529) (T530), -OS (O ₂ ) -T531, -NHC (O) -T532, -NT533C (O) -T534, -NH-C (O) -O-T535, -NH-C (O) -NH-T536, -NH-C (O ) -NT537T538, -NT539-C (O) -O-T540, -NT541-C (O) -NH-T542, -NT543-C (O) -NT544T545, -NHS (O ₂ ) -T546, -NT547S (O ₂ ) -T548, -S-T549, -S (O) -T550, -S (O ₂ ) -T551, -S (O ₂ ) NH-T552, -S (O ₂ ) NT553T554, -S (O ₂ ) O-T555, -P (O) (OT556) (OT557), -Si (T558) (T559) (T560) ";
At that time, T509, T510, T511, T512, T513, T514, T515, T516, T517, T518, T519, T520, T521, T522, T523, T524, T525, T526, T527, T528, T529, T530, T531, T532 , T533, T534, T535, T536, T537, T538, T539, T540, T541, T542, T543, T544, T545, T546, T547, T548, T549, T550, T551, T552, T553, T554, T555, T556 , T558, T559, T560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T515, T516 and / or T524, T525 and / or T537, T538 and / or T544, T545 and / or T553, T554 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT561, -NT562T563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T564, -C (O) O-T565, -C (O) NH-T566, -C (O) NT567T568, -O-T569, -O (-T570-O) _b -H (b = 1, 2, 3, 4, 5), -O (-T571-O) _b -T572 (b = 1, 2, 3, 4, 5), -OC (O) -T573, -OC (O) -O-T574, -OC (O) -NHT575, -O-C (O)- NT576T577, -OP (O) (OT578) (OT579), -OSi (T580) (T581) (T582), -OS (O ₂ ) -T583, -NHC (O) -T584, -NT585C (O) -T586, -NH-C (O) -O-T587, -NH-C (O) -NH-T588, -NH-C (O ) -NT589T590, -NT591-C (O) -O-T592, -NT593-C (O) -NH-T594, -NT595-C (O) -NT596T597, -NHS (O ₂ ) -T598, -NT599S (O ₂ ) -T600, -S-T601, -S (O) -T602, -S (O ₂ ) -T603, -S (O ₂ ) NH-T604, -S (O ₂ ) NT605T606, -S (O ₂ ) O-T607, -P (O) (OT608) (OT609), -Si (T610) (T611) (T612) ";
At that time, T561, T562, T563, T564, T565, T566, T567, T568, T569, T570, T571, T572, T573, T574, T575, T576, T577, T578, T579, T580, T581, T582, T583, T583 T585, T586, T587, T588, T589, T590, T591, T592, T593, T594, T595, T596, T597, T598, T599, T600, T601, T602, T603, T604, T605, T606, T607, T608 , T610, T611, T612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T567, T568 and / or T576, T577 and / or T589, T590 and / or T596, T597 and / or T605, T606 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT613, -NT614T615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T616, -C (O) O-T617, -C (O) NH-T618, -C (O) NT619T620, -O-T621, -O (-T622-O) _c -H (c = 1, 2, 3, 4, 5), -O (-T623-O) _c -T624 (c = 1, 2, 3, 4, 5), -OC (O) -T625, -OC (O) -O-T626, -OC (O) -NHT627, -O-C (O)- NT628T629, -OP (O) (OT630) (OT631), -OSi (T632) (T633) (T634), -OS (O ₂ ) -T635, -NHC (O) -T636, -NT637C (O) -T638, -NH-C (O) -O-T639, -NH-C (O) -NH-T640, -NH-C (O ) -NT641T642, -NT643-C (O) -O-T644, -NT645-C (O) -NH-T646, -NT647-C (O) -NT648T649, -NHS (O ₂ ) -T650, -NT651S (O ₂ ) -T652, -S-T653, -S (O) -T654, -S (O ₂ ) -T655, -S (O ₂ ) NH-T656, -S (O ₂ ) NT657T658, -S (O ₂ ) O-T659, -P (O) (OT660) (OT661), -Si (T662) (T663) (T664) ";
At that time, T613, T614, T615, T616, T617, T618, T619, T620, T621, T622, T623, T624, T625, T626, T627, T628, T629, T630, T631, T632, T633, T636, T636, T636 , T637, T638, T639, T640, T641, T642, T643, T644, T645, T646, T647, T648, T649, T650, T651, T652, T653, T654, T655, T656, T657, T658, T659, T660 , T662, T663, T664 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T619, T620 and / or T628, T629 and / or T641, T642 and / or T648, T649 and / or T657, T658 may each be taken together to form a “heterocyclyl”;
as well as
One of the groups Z28, Z29, independently of each other, is selected from the group consisting of: or neither of the groups Z28, Z29 is selected from the group consisting of:
(III) "hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl";
In this case, the substituents of the substituent group (III) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT665, -NT666T667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T668, -C (O) O-T669, -C (O) NH-T670, -C (O) NT671T672, -O-T673, -O (-T674-O) _d -H (d = 1, 2, 3, 4, 5), -O (-T675-O) _d -T676 (d = 1, 2, 3, 4, 5), -OC (O) -T677, -OC (O) -O-T678, -OC (O) -NHT679, -O-C (O)- NT680T681, -OP (O) (OT682) (OT683), -OSi (T684) (T685) (T686), -OS (O ₂ ) -T687, -NHC (O) -T688, -NT689C (O) -T690, -NH-C (O) -O-T691, -NH-C (O) -NH-T692, -NH-C (O ) -NT693T694, -NT695-C (O) -O-T696, -NT697-C (O) -NH-T698, -NT699-C (O) -NT700T701, -NHS (O ₂ ) -T702, -NT703S (O ₂ ) -T704, -S-T705, -S (O) -T706, -S (O ₂ ) -T707, -S (O ₂ ) NH-T708, -S (O ₂ ) NT709T710, -S (O ₂ ) O-T711, -P (O) (OT712) (OT713), -Si (T714) (T715) (T716) ";
At that time, T665, T666, T667, T668, T669, T670, T671, T672, T673, T674, T675, T676, T677, T678, T679, T680, T681, T682, T683, T684, T685, T686, T687, T687 T689, T690, T691, T692, T693, T694, T695, T696, T697, T698, T699, T700, T701, T702, T703, T704, T705, T706, T707, T708, T709, T710, T711, T712 , T714, T715, T716 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T671, T672 and / or T680, T681 and / or T693, T694 and / or T700, T701 and / or T709, T710 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT717, -NT718T719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T720, -C (O) O-T721, -C (O) NH-T722, -C (O) NT723T724, -O-T725, -O (-T726-O) _e -H (e = 1, 2, 3, 4, 5), -O (-T727-O) _e -T728 (e = 1, 2, 3, 4, 5), -OC (O) -T729, -OC (O) -O-T730, -OC (O) -NHT731, -O-C (O)- NT732T733, -OP (O) (OT734) (OT735), -OSi (T736) (T737) (T738), -OS (O ₂ ) -T739, -NHC (O) -T740, -NT741C (O) -T742, -NH-C (O) -O-T743, -NH-C (O) -NH-T744, -NH-C (O ) -NT745T746, -NT747-C (O) -O-T748, -NT749-C (O) -NH-T750, -NT751-C (O) -NT752T753, -NHS (O ₂ ) -T754, -NT755S (O ₂ ) -T756, -S-T757, -S (O) -T758, -S (O ₂ ) -T759, -S (O ₂ ) NH-T760, -S (O ₂ ) NT761T762, -S (O ₂ ) O-T763, -P (O) (OT764) (OT765), -Si (T766) (T767) (T768) ";
At that time, T717, T718, T719, T720, T721, T722, T723, T724, T725, T726, T727, T728, T729, T730, T731, T732, T733, T734, T735, T736, T737, T738, T739, T7 T741, T742, T743, T744, T745, T746, T747, T748, T749, T750, T751, T752, T753, T754, T755, T756, T757, T758, T759, T760, T761, T762, T763, T764 , T766, T767, T768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T723, T724 and / or T732, T733 and / or T745, T746 and / or T752, T753 and / or T761, T762 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be substituted with at least one substituent selected from the group consisting of the same or different, independent of each other:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT769, -NT770T771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T772, -C (O) O-T773, -C (O) NH-T774, -C (O) NT775T776, -O-T777, -O (-T778-O) _f -H (f = 1, 2, 3, 4, 5), -O (-T779-O) _f -T780 (f = 1, 2, 3, 4, 5), -OC (O) -T781, -OC (O) -O-T782, -OC (O) -NHT783, -O-C (O)- NT784T785, -OP (O) (OT786) (OT787), -OSi (T788) (T789) (T790), -OS (O ₂ ) -T791, -NHC (O) -T792, -NT793C (O) -T794, -NH-C (O) -O-T795, -NH-C (O) -NH-T796, -NH-C (O ) -NT797T798, -NT799-C (O) -O-T800, -NT801-C (O) -NH-T802, -NT803-C (O) -NT804T805, -NHS (O ₂ ) -T806, -NT807S (O ₂ ) -T808, -S-T809, -S (O) -T810, -S (O ₂ ) -T811, -S (O ₂ ) NH-T812, -S (O ₂ ) NT813T814, -S (O ₂ ) O-T815, -P (O) (OT816) (OT817), -Si (T818) (T819) (T820) ";
At that time, T769, T770, T771, T772, T773, T774, T775, T776, T777, T778, T779, T780, T781, T782, T783, T784, T785, T786, T787, T788, T789, T790, T791, 792 T793, T794, T795, T796, T797, T798, T799, T800, T801, T802, T803, T804, T805, T806, T807, T808, T809, T810, T811, T812, T813, T814, T815, T816 , T818, T819, T820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T775, T776 and / or T784, T785 and / or T797, T798 and / or T804, T805 and / or T813, T814 may each be taken together to form a “heterocyclyl”;
(2) "-C (Y5) NZ33-Y6-Z34";
In this case, Y5 and T6 are selected from the group consisting of “O, S, ═NH, ═NZ35” independently of each other;
Z33, Z34, Z35 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In this case, the substituents of the substituent group (II) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT821, -NT822T823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T824, -C (O) O-T825, -C (O) NH-T826, -C (O) NT827T828, -O-T829, -O (-T830-O) _g -H (g = 1, 2, 3, 4, 5), -O (-T831-O) _g -T832 (g = 1, 2, 3, 4, 5), -OC (O) -T833, -OC (O) -O-T834, -OC (O) -NHT835, -O-C (O)- NT836T837, -OP (O) (OT838) (OT839), -OSi (T840) (T841) (T842), -OS (O ₂ ) -T843, -NHC (O) -T844, -NT845C (O) -T846, -NH-C (O) -O-T847, -NH-C (O) -NH-T848, -NH-C (O ) -NT849T850, -NT851-C (O) -O-T852, -NT853-C (O) -NH-T854, -NT855-C (O) -NT856T857, -NHS (O ₂ ) -T858, -NT859S (O ₂ ) -T860, -S-T861, -S (O) -T862, -S (O ₂ ) -T863, -S (O ₂ ) NH-T864, -S (O ₂ ) NT865T866, -S (O ₂ ) O-T867, -P (O) (OT868) (OT869), -Si (T870) (T871) (T872) ";
At that time, T821, T822, T823, T824, T825, T826, T827, T828, T829, T830, T831, T832, T833, T834, T835, T836, T837, T838, T833, T840, T841, T842, T843, T843 T845, T846, T847, T848, T849, T850, T851, T852, T853, T854, T855, T856, T857, T858, T859, T860, T861, T862, T863, T864, T865, T866, T867, T868 , T870, T871, T872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T827, T828 and / or T836, T837 and / or T849, T850 and / or T856, T857 and / or T865, T866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT873, -NT874T875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T876, -C (O) O-T877, -C (O) NH-T878, -C (O) NT879T880, -O-T881, -O (-T882-O) _h -H (h = 1, 2, 3, 4, 5), -O (-T883-O) _h -T884 (h = 1, 2, 3, 4, 5), -OC (O) -T885, -OC (O) -O-T886, -OC (O) -NHT887, -O-C (O)- NT888T889, -OP (O) (OT890) (OT891), -OSi (T892) (T893) (T894), -OS (O ₂ ) -T895, -NHC (O) -T896, -NT897C (O) -T898, -NH-C (O) -O-T899, -NH-C (O) -NH-T900, -NH-C (O ) -NT901T902, -NT903-C (O) -O-T904, -NT905-C (O) -NH-T906, -NT907-C (O) -NT908T909, -NHS (O ₂ ) -T910, -NT911S (O ₂ ) -T912, -S-T913, -S (O) -T914, -S (O ₂ ) -T915, -S (O ₂ ) NH-T916, -S (O ₂ ) NT917T918, -S (O ₂ ) O-T919, -P (O) (OT920) (OT921), -Si (T922) (T923) (T924) ";
At that time, T873, T874, T875, T876, T877, T878, T879, T880, T881, T882, T883, T884, T885, T886, T887, T888, T889, T890, T891, T892, T893, T894, T895, T895 T897, T898, T899, T900, T901, T902, T903, T904, T905, T906, T907, T908, T909, T910, T911, T912, T913, T914, T915, T916, T917, T918, T919, T920 , T922, T923, T924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T879, T880 and / or T888, T889 and / or T901, T902 and / or T908, T909 and / or T917, T918 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT925, -NT926T927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T928, -C (O) O-T929, -C (O) NH-T930, -C (O) NT931T932, -O-T933, -O (-T934-O) _i -H (i = 1, 2, 3, 4, 5), -O (-T935-O) _i -T936 (i = 1, 2, 3, 4, 5), -OC (O) -T937, -OC (O) -O-T938, -OC (O) -NHT939, -O-C (O)- NT940T941, -OP (O) (OT942) (OT943), -OSi (T944) (T945) (T946), -OS (O ₂ ) -T947, -NHC (O) -T948, -NT949C (O) -T950, -NH-C (O) -O-T951, -NH-C (O) -NH-T952, -NH-C (O ) -NT953T954, -NT955-C (O) -O-T956, -NT957-C (O) -NH-T958, -NT959-C (O) -NT960T961, -NHS (O ₂ ) -T962, -NT963S (O ₂ ) -T964, -S-T965, -S (O) -T966, -S (O ₂ ) -T967, -S (O ₂ ) NH-T968, -S (O ₂ ) NT969T970, -S (O ₂ ) O-T971, -P (O) (OT972) (OT973), -Si (T974) (T975) (T976) ";
In that case, T925, T926, T927, T929, T929, T930, T931, T932, T933, T934, T935, T936, T937, T938, T939, T940, T941, T942, T943, T944, T945, T946, T947, T948 , T949, T950, T951, T952, T953, T954, T955, T95, T957, T958, T959, T960, T961, T962, T963, T964, T965, T966, T967, T968, T969, T970, T971, T972 , T974, T975, T976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T931, T932 and / or T940, T941 and / or T953, T954 and / or T960, T961 and / or T969, T970 can each be taken together to form a “heterocyclyl”;
as well as
One of the groups Z26, Z27, independently of one another, is selected from the group consisting of: or neither of the groups Z26, Z27 is selected from the group consisting of:
(3) "Hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -C (Y7) NZ36Z37, -C (= NZ38) -Z39, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
Y7 is selected from the group consisting of “O, S, ═NH, ═NZ40” independently of each other;
In so doing, the groups Z36, Z37, Z38, Z39, Z40 are selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In that case, depending on the case, the substituents of the substituent group (3) and / or the substituent group (I) are at least one substituent selected from the group consisting of the following, the same or different, independently of each other: It may be further substituted by a group:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT977, -NT978T979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T980, -C (O) O-T981, -C (O) NH-T982, -C (O) NT983T984, -O-T985, -O (-T986-O) _j -H (j = 1, 2, 3, 4, 5), -O (-T987-O) _j -T988 (j = 1, 2, 3, 4, 5), -OC (O) -T989, -OC (O) -O-T990, -OC (O) -NHT991, -O-C (O)- NT992T993, -OP (O) (OT994) (OT995), -OSi (T996) (T997) (T998), -OS (O ₂ ) -T999, -NHC (O) -T1000, -NT1001C (O) -T1002, -NH-C (O) -O-T1003, -NH-C (O) -NH-T1004, -NH-C (O ) -NT1005T1006, -NT1007-C (O) -O-T1008, -NT1009-C (O) -NH-T1010, -NT1011-C (O) -NT1012T1013, -NHS (O ₂ ) -T1014, -NT1015S (O ₂ ) -T1016, -S-T1017, -S (O) -T1018, -S (O ₂ ) -T1019, -S (O ₂ ) NH-T1020, -S (O ₂ ) NT1021T1022, -S (O ₂ ) O-T1023, -P (O) (OT1024) (OT1025), -Si (T1026) (T1027) (T1028) ";
In that case, T977, T978, T979, T980, T981, T982, T983, T984, T985, T986, T987, T988, T989, T990, T991, T992, T993, T994, T995, T996, T997, T998, T999, 1000 T1001, T1002, T1003, T1004, T1005, T1006, T1007, T1008, T1009, T1010, T1011, T1012, T1013, T1014, T1015, T1016, T1017, T1018, T1019, T1020, T1021, T1022, T1023, T1024 , T1026, T1027, T1028 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T983, T984 and / or T992, T993 and / or T1005, T1006 and / or T1012, T1013 and / or T1021, T1022 may each be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1029, -NT1030T1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1032, -C (O) O-T1033, -C (O) NH-T1034, -C (O) NT1035T1036, -O-T1037, -O (-T1038-O) _k -H (k = 1, 2, 3, 4, 5), -O (-T1039-O) _k -T1040 (k = 1, 2, 3, 4, 5), -OC (O) -T1041, -OC (O) -O-T1042, -OC (O) -NHT1043, -O-C (O)- NT1044T1045, -OP (O) (OT1046) (OT1047), -OSi (T1048) (T1049) (T1050), -OS (O ₂ ) -T1051, -NHC (O) -T1052, -NT1053C (O) -T1054, -NH-C (O) -O-T1055, -NH-C (O) -NH-T1056, -NH-C (O ) -NT1057T1058, -NT1059-C (O) -O-T1060, -NT1061-C (O) -NH-T1062, -NT1063-C (O) -NT1064T1065, -NHS (O ₂ ) -T1066, -NT1067S (O ₂ ) -T1068, -S-T1069, -S (O) -T1070, -S (O ₂ ) -T1071, -S (O ₂ ) NH-T1072, -S (O ₂ ) NT1073T1074, -S (O ₂ ) O-T1075, -P (O) (OT1076) (OT1077), -Si (T1078) (T1079) (T1080) ";
At that time, T1029, T1030, T1031, T1032, T1033, T1034, T1035, T1036, T1037, T1038, T1039, T1040, T1041, T1042, T1043, T1044, T1045, T1046, T1047, T1048, T1049, T1050, T1051, T1052, . , T1078, T1079, T1080 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1035, T1036 and / or T1044, T1045 and / or T1057, T1058, and / or T1064, T1065, and / or T1073, T1074 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1081, -NT1082T1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1084, -C (O) O-T1085, -C (O) NH-T1086, -C (O) NT1087T1088, -O-T1089, -O (-T1090-O) _l -H (l = 1, 2, 3, 4, 5), -O (-T1091-O) _l -T1092 (l = 1, 2, 3, 4, 5), -OC (O) -T1093, -OC (O) -O-T1094, -OC (O) -NHT1095, -O-C (O)- NT1096T1097, -OP (O) (OT1098) (OT1099), -OSi (T1100) (T1101) (T1102), -OS (O ₂ ) -T1103, -NHC (O) -T1104, -NT1105C (O) -T1106, -NH-C (O) -O-T1107, -NH-C (O) -NH-T1108, -NH-C (O ) -NT1109T1110, -NT1111-C (O) -O-T1112, -NT1113-C (O) -NH-T1114, -NT1115-C (O) -NT1116T1117, -NHS (O ₂ ) -T1118, -NT1119S (O ₂ ) -T1120, -S-T1121, -S (O) -T1122, -S (O ₂ ) -T1123, -S (O ₂ ) NH-T1124, -S (O ₂ ) NT1125T1126, -S (O ₂ ) O-T1127, -P (O) (OT1128) (OT1129), -Si (T1130) (T1131) (T1132) ";
At that time, T1081, T1082, T1083, T1084, T1085, T1086, T1087, T1088, T1089, T1090, T1091, T1092, T1093, T1094, T1095, T1096, T1097, T1098, T1099, T1100, T1101, T1102, T1103, T1104 , T1105, T1106, T1107, T1108, T1109, T1110, T1111, T1112, T1113, T1114, T1115, T1116, T1117, T1118, T1119, T1120, T1121, T1122, T1123, T1124, T1125, T1126, T1127, T1128 , T1130, T1131, T1132, independently of one another, are “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1087, T1088 and / or T1096, T1097 and / or T1109, T1110 and / or T1116, T1117 and / or T1125, T1126 may each be taken together to form a "heterocyclyl";
as well as
One of the groups Z1, Z2, independently of each other, is selected from the group consisting of: or neither of the groups Z1, Z2 is selected from the group consisting of:
(C) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1133, -NT1134T1135, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ -C (O) -T1136, -C (O) O-T1137, -C (O) NH-T1138, -C (O) NT1139T1140, -O-T1141, -O (-T1142-O) _m -H (m = 1, 2, 3, 4, 5), -O (-T1143-O) _m -T1144 (m = 1, 2, 3, 4, 5), -OC (O) -T1145, -OC (O) -O-T1146, -OC (O) -NHT1147, -O-C (O)- NT1148T1149, -OP (O) (OT1150) (OT1151), -OSi (T1152) (T1153) (T1154), -OS (O ₂ ) -T1155, -NHC (O) -T1156, -NT1157C (O) -T1158, -NH-C (O) -O-T1159, -NH-C (O) -NH-T1160, -NH-C (O ) -NT1161T1162, -NT1163-C (O) -O-T1164, -NT1165-C (O) -NH-T1166, -NT1167-C (O) -NT1168T1169, -NHS (O ₂ ) -T1170, -NT1171S (O ₂ ) -T1172, -S-T1173, -S (O) -T1174, -S (O ₂ ) -T1175, -S (O ₂ ) NH-T1176, -S (O ₂ ) NT1177T1178, -S (O ₂ ) O-T1179, -P (O) (OT1180) (OT1181), -Si (T1182) (T1183) (T1184) ";
At that time, T1133, T1134, T1135, T1136, T1137, T1138, T1139, T1140, T1141, T1142, T1143, T1144, T1145, T1146, T1147, T1148, T1149, T1150, T1151, T1152, T1153, T1156, T1156, T1156, T1157, T1158, T1159, T1160, T1161, T1162, T1163, T1164, T1165, T1166, T1167, T1168, T1169, T1170, T1171, T1172, T1173, T1174, T1175, T1176, T1177, T1178, T1179, T1180 , T1182, T1183, T1184 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1139, T1140 and / or T1148, T1149 and / or T1161, T1162 and / or T1168, T1169 and / or T1177, T1178 may each be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1185, -NT1186T1187, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1188, -C (O) O-T1189, -C (O) NH-T1190, -C (O) NT1191T1192, -O-T1193, -O (-T1194-O) _n -H (n = 1, 2, 3, 4, 5), -O (-T1195-O) _n -T1196 (n = 1, 2, 3, 4, 5), -OC (O) -T1197, -OC (O) -O-T1198, -OC (O) -NHT1199, -O-C (O)- NT1200T1201, -OP (O) (OT1202) (OT1203), -OSi (T1204) (T1205) (T1206), -OS (O ₂ ) -T1207, -NHC (O) -T1208, -NT1209C (O) -T1210, -NH-C (O) -O-T1211, -NH-C (O) -NH-T1212, -NH-C (O ) -NT1213T1214, -NT1215-C (O) -O-T1216, -NT1217-C (O) -NH-T1218, -NT1219-C (O) -NT1220T1221, -NHS (O ₂ ) -T1222, -NT1223S (O ₂ ) -T1224, -S-T1225, -S (O) -T1226, -S (O ₂ ) -T1227, -S (O ₂ ) NH-T1228, -S (O ₂ ) NT1229T1230, -S (O ₂ ) O-T1231, -P (O) (OT1232) (OT1233), -Si (T1234) (T1235) (T1236) ";
At that time, T1185, T1186, T1187, T1188, T1189, T1190, T1191, T1192, T1193, T1194, T1195, T1196, T1197, T1198, T1199, T1200, T1201, T1202, T1203, T1204, T1205, T1206, T1207, T1208 , T1209, T1210, T1211, T1212, T1213, T1214, T1215, T1216, T1217, T1218, T1219, T1220, T1221, T1222, T1223, T1224, T1225, T1226, T1227, T1228, T1229, T1230, T1231, 3312 , T1234, T1235, and T1236 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1191, T1192 and / or T1200, T1201, and / or T1213, T1214 and / or T1220, T1221 and / or T1229, T1230 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be substituted with at least one substituent selected from the group consisting of the following, independently or identically:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1237, -NT1238T1239, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1240, -C (O) O-T1241, -C (O) NH-T1242, -C (O) NT1243T1244, -O-T1245, -O (-T1246-O) _o -H (o = 1, 2, 3, 4, 5), -O (-T1247-O) _o -T1248 (o = 1, 2, 3, 4, 5), -OC (O) -T1249, -OC (O) -O-T1250, -OC (O) -NHT1251, -O-C (O)- NT1252T1253, -OP (O) (OT1254) (OT1255), -OSi (T1256) (T1257) (T1258), -OS (O ₂ ) -T1259, -NHC (O) -T1260, -NT1261C (O) -T1262, -NH-C (O) -O-T1263, -NH-C (O) -NH-T1264, -NH-C (O ) -NT1265T1266, -NT1267-C (O) -O-T1268, -NT1269-C (O) -NH-T1270, -NT1271-C (O) -NT1272T1273, -NHS (O ₂ ) -T1274, -NT1275S (O ₂ ) -T1276, -S-T1277, -S (O) -T1278, -S (O ₂ ) -T1279, -S (O ₂ ) NH-T1280, -S (O ₂ ) NT1281T1282, -S (O ₂ ) O-T1283, -P (O) (OT1284) (OT1285), -Si (T1286) (T1287) (T1288) ";
At that time, T1237, T1238, T1239, T1240, T1241, T1242, T1243, T1244, T1245, T1246, T1247, T1248, T1249, T1250, T1251, T1252, T1253, T1254, T1255, T1256, T1257, T1258, T1258, T1259, T1259 , T1261, T1262, T1263, T1264, T1265, T1266, T1267, T1268, T1269, T1270, T1271, T1272, T1273, T1274, T1275, T1276, T1277, T1278, T1279, T1280, T1281, T1282, T1283, T1284 , T1286, T1287, T1288 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1243, T1244 and / or T1252, T1253 and / or T1265, T1266 and / or T1272, T1273 and / or T1281, T1282 may be taken together to form a “heterocyclyl”;
(D) -NZ41Z42,
The groups Z41, Z42 are then selected from the group consisting of:
(1) "Alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl ";
In this case, the substituents of the substituent group (1) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1289, -NT1290T1291, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1292, -C (O) O-T1293, -C (O) NH-T1294, -C (O) NT1295T1296, -O-T1297, -O (-T1298-O) _rr -H (rr = 1, 2, 3, 4, 5), -O (-T1299-O) _rr -T1300 (rr = 1, 2, 3, 4, 5), -OC (O) -T1301, -OC (O) -O-T1302, -OC (O) -NHT1303, -O-C (O)- NT1304T1305, -OP (O) (OT1306) (OT1307), -OSi (T1308) (T1309) (T1310), -OS (O ₂ ) -T1311, -NHC (O) -T1312, -NT1313C (O) -T1314, -NH-C (O) -O-T1315, -NH-C (O) -NH-T1316, -NH-C (O ) -NT1317T1318, -NT1319-C (O) -O-T1320, -NT1321-C (O) -NH-T1322, -NT1323-C (O) -NT1324T1325, -NHS (O ₂ ) -T1326, -NT1327S (O ₂ ) -T1328, -S-T1329, -S (O) -T1330, -S (O ₂ ) -T1331, -S (O ₂ ) NH-T1332, -S (O ₂ ) NT1333T1334, -S (O ₂ ) O-T1335, -P (O) (OT1336) (OT1337), -Si (T1338) (T1339) (T1340) ";
At that time, T1289, T1290, T1291, T1292, T1293, T1294, T1295, T1296, T1297, T1298, T1299, T1300, T1301, T1302, T1303, T1304, T1305, T1306, T1307, T1308, T1309, T1310, T1311, T1311 T1313, T1314, T1315, T1316, T1317, T1318, T1319, T1320, T1321, T1322, T1323, T1324, T1325, T1326, T1327, T1328, T1329, T1330, T1331, T1332, T1333, T1336, T1335, T1336 , T1338, T1339, T1340, independently of each other ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1295, T1296 and / or T1304, T1305 and / or T1317, T1318 and / or T1324, T1325 and / or T1333, T1334 may be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1341, -NT1342T1343, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1344, -C (O) O-T1345, -C (O) NH-T1346, -C (O) NT1347T1348, -O-T1349, -O (-T1350-O) _rs -H (rs = 1, 2, 3, 4, 5), -O (-T1351-O) _rs -T1352 (rs = 1, 2, 3, 4, 5), -OC (O) -T1353, -OC (O) -O-T1354, -OC (O) -NHT1355, -O-C (O)- NT1356T1357, -OP (O) (OT1358) (OT1359), -OSi (T1360) (T1361) (T1362), -OS (O ₂ ) -T1363, -NHC (O) -T1364, -NT1365C (O) -T1366, -NH-C (O) -O-T1367, -NH-C (O) -NH-T1368, -NH-C (O ) -NT1369T1370, -NT1371-C (O) -O-T1372, -NT1373-C (O) -NH-T1374, -NT1375-C (O) -NT1376T1377, -NHS (O ₂ ) -T1378, -NT1379S (O ₂ ) -T1380, -S-T1381, -S (O) -T1382, -S (O ₂ ) -T1383, -S (O ₂ ) NH-T1384, -S (O ₂ ) NT1385T1386, -S (O ₂ ) O-T1387, -P (O) (OT1388) (OT1389), -Si (T1390) (T1391) (T1392) ";
In that case, T1341, T1342, T1343, T1344, T1345, T1346, T1347, T1348, T1349, T1350, T1351, T1352, T1353, T1354, T1355, T1356, T1357, T1358, T1359, T1360, T1363, T1363, T1363, T1363 T1365, T1366, T1367, T1368, T1369, T1370, T1371, T1372, T1373, T1374, T1375, T1376, T1377, T1378, T1379, T1380, T1381, T1382, T1383, T1384, T1385, T1388, T1387, T1388 , T1390, T1391, and T1392 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1347, T1348 and / or T1356, T1357 and / or T1369, T1370 and / or T1376, T1377 and / or T1385, T1386 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1393, -NT1394T1395, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1396, -C (O) O-T1397, -C (O) NH-T1398, -C (O) NT1399T1400, -O-T1401, -O (-T1402-O) _rt -H (rt = 1, 2, 3, 4, 5), -O (-T1403-O) _rt -T1404 (rt = 1, 2, 3, 4, 5), -OC (O) -T1405, -OC (O) -O-T1406, -OC (O) -NHT1407, -O-C (O)- NT1408T1409, -OP (O) (OT1410) (OT1411), -OSi (T1412) (T1413) (T1414), -OS (O ₂ ) -T1415, -NHC (O) -T1416, -NT1417C (O) -T1418, -NH-C (O) -O-T1419, -NH-C (O) -NH-T1420, -NH-C (O ) -NT1421T1422, -NT1423-C (O) -O-T1424, -NT1425-C (O) -NH-T1426, -NT1427-C (O) -NT1428T1429, -NHS (O ₂ ) -T1430, -NT1431S (O ₂ ) -T1432, -S-T1433, -S (O) -T1434, -S (O ₂ ) -T1435, -S (O ₂ ) NH-T1436, -S (O ₂ ) NT1437T1438, -S (O ₂ ) O-T1439, -P (O) (OT1440) (OT1441), -Si (T1442) (T1443) (T1444) ";
At that time, T1393, T1394, T1395, T1396, T1397, T1398, T1399, T1400, T1401, T1402, T1403, T1404, T1405, T1406, T1407, T1408, T1409, T1410, T1411, T1412, T1413, T1414, T1414, T1414, T1415 , T1417, T1418, T1419, T1420, T1421, T1422, T1423, T1424, T1425, T1426, T1427, T1428, T1429, T1430, T1431, T1432, T1433, T1434, T1435, T1436, T1437, T1438, T1439, T1440 , T1442, T1443, T1444 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1399, T1400 and / or T1408, T1409 and / or T1421, T1422 and / or T1428, T1429 and / or T1437, T1438 may be taken together to form a "heterocyclyl";
(2) "-C (O) -C (O) -T1445, -S (O ₂ ) -NT1446T1447 ";
T1445, T1446, T1447 are then selected from the group consisting of the following, independently of each other:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1448, -NT1449T1450, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1451, -C (O) O-T1452, -C (O) NH-T1453, -C (O) NT1454T1455, -O-T1456, -O (-T1457-O) _ru -H (ru = 1, 2, 3, 4, 5), -O (-T1458-O) _ru -T1459 (ru = 1, 2, 3, 4, 5), -OC (O) -T1460, -OC (O) -O-T1461, -OC (O) -NHT1462, -O-C (O)- NT1463T1464, -OP (O) (OT1465) (OT1466), -OSi (T1467) (T1468) (T1469), -OS (O ₂ ) -T1470, -NHC (O) -T1471, -NT1472C (O) -T1473, -NH-C (O) -O-T1474, -NH-C (O) -NH-T1475, -NH-C (O ) -NT1476T1477, -NT1478-C (O) -O-T1479, -NT1480-C (O) -NH-T1481, -NT1482-C (O) -NT1483T1484, -NHS (O ₂ ) -T1485, -NT1486S (O ₂ ) -T1487, -S-T1488, -S (O) -T1489, -S (O ₂ ) -T1490, -S (O ₂ ) NH-T1491, -S (O ₂ ) NT1492T1493, -S (O ₂ ) O-T1494, -P (O) (OT1495) (OT1496), -Si (T1497) (T1498) (T1499) ";
At that time, T1448, T1449, T1450, T1451, T1452, T1453, T1454, T1455, T1456, T1457, T1458, T1458, T1460, T1461, T1462, T1463, T1464, T1465, T1466, T1467, T1468, T1469, T1470, T1471 . , T1497, T1498, T1499 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1454, T1455 and / or T1463, T1464 and / or T1476, T1477 and / or T1483, T1484 and / or T1492, T1493 can also be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1500, -NT1501T1502, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1503, -C (O) O-T1504, -C (O) NH-T1505, -C (O) NT1506T1507, -O-T1508, -O (-T1509-O) _rv -H (rv = 1, 2, 3, 4, 5), -O (-T1510-O) _rv -T1511 (rv = 1, 2, 3, 4, 5), -OC (O) -T1512, -OC (O) -O-T1513, -OC (O) -NHT1514, -O-C (O)- NT1515T1516, -OP (O) (OT1517) (OT1518), -OSi (T1519) (T1520) (T1521), -OS (O ₂ ) -T1522, -NHC (O) -T1523, -NT1524C (O) -T1525, -NH-C (O) -O-T1526, -NH-C (O) -NH-T1527, -NH-C (O ) -NT1528T1529, -NT1530-C (O) -O-T1531, -NT1532-C (O) -NH-T1533, -NT1534-C (O) -NT1535T1536, -NHS (O ₂ ) -T1537, -NT1538S (O ₂ ) -T1539, -S-T1540, -S (O) -T1541, -S (O ₂ ) -T1542, -S (O ₂ ) NH-T1543, -S (O ₂ ) NT1544T1545, -S (O ₂ ) O-T1546, -P (O) (OT1547) (OT1548), -Si (T1549) (T1550) (T1551) ";
At that time, T1500, T1501, T1502, T1503, T1504, T1505, T1506, T1507, T1508, T1509, T1510, T1511, T1512, T1513, T1514, T1515, T1516, T1517, T1518, T1519, T1520, T1521, T1523 T1524, T1525, T1526, T1527, T1528, T1529, T1530, T1531, T1532, T1533, T1534, T1535, T1536, T1537, T1538, T1539, T1540, T1541, T1542, T1543, T1544, T1545, T1546, T1547 , T1549, T1550, T1551 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1506, T1507 and / or T1515, T1516 and / or T1528, T1529 and / or T1535, T1536 and / or T1544, T1545 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1552, -NT1553T1554, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1555, -C (O) O-T1556, -C (O) NH-T1557, -C (O) NT1558T1559, -O-T1560, -O (-T1561-O) _rw -H (rw = 1, 2, 3, 4, 5), -O (-T1562-O) _rw -T1563 (rw = 1, 2, 3, 4, 5), -OC (O) -T1564, -OC (O) -O-T1565, -OC (O) -NHT1566, -O-C (O)- NT1567T1568, -OP (O) (OT1569) (OT1570), -OSi (T1571) (T1572) (T1573), -OS (O ₂ ) -T1574, -NHC (O) -T1558, -NT1576C (O) -T1577, -NH-C (O) -O-T1578, -NH-C (O) -NH-T1579, -NH-C (O ) -NT1580T1581, -NT1582-C (O) -O-T1583, -NT1584-C (O) -NH-T1585, -NT1586-C (O) -NT1587T1588, -NHS (O ₂ ) -T1589, -NT1590S (O ₂ ) -T1591, -S-T1592, -S (O) -T1593, -S (O ₂ ) -T1594, -S (O ₂ ) NH-T1595, -S (O ₂ ) NT1596T1597, -S (O ₂ ) O-T1598, -P (O) (OT1599) (OT1600), -Si (T1601) (T1602) (T1603) ";
At that time, T1552, T1553, T1554, T1555, T1556, T1557, T1558, T1559, T1560, T1561, T1562, T1563, T1564, T1565, T1566, T1567, T1568, T1568, T1570, T1571, T1573, T1573, T1574, . , T1601, T1602, and T1603 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1558, T1559 and / or T1657, T1568 and / or T1580, T1581 and / or T1587, T1588 and / or T1596, T1597 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1604, -NT1605T1606, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1607, -C (O) O-T1608, -C (O) NH-T1609, -C (O) NT1610T1611, -O-T1612, -O (-T1613-O) _rx -H (rx = 1, 2, 3, 4, 5), -O (-T1614-O) _rx -T1615 (rx = 1, 2, 3, 4, 5), -OC (O) -T1616, -OC (O) -O-T1617, -OC (O) -NHT1618, -O-C (O)- NT1619T1620, -OP (O) (OT1621) (OT1622), -OSi (T1623) (T1624) (T1625), -OS (O ₂ ) -T1626, -NHC (O) -T1627, -NT1628C (O) -T1629, -NH-C (O) -O-T1630, -NH-C (O) -NH-T1631, -NH-C (O ) -NT1632T1633, -NT1634-C (O) -O-T1635, -NT1636-C (O) -NH-T1637, -NT1638-C (O) -NT1639T1640, -NHS (O ₂ ) -T1641, -NT1642S (O ₂ ) -T1643, -S-T1644, -S (O) -T1645, -S (O ₂ ) -T1646, -S (O ₂ ) NH-T1647, -S (O ₂ ) NT1648T1649, -S (O ₂ ) O-T1650, -P (O) (OT1651) (OT1652), -Si (T1653) (T1654) (T1655) ";
At that time, T1604, T1605, T1606, T1607, T1608, T1609, T1610, T1611, T1612, T1613, T1614, T1615, T1616, T1617, T1618, T1619, T1620, T1621, T1622, T1623, T1624, T1625, T1626, T1627 , T1628, T1629, T1630, T1631, T1632, T1633, T1634, T1635, T1636, T1637, T1638, T1639, T1640, T1641, T1642, T1643, T1644, T1645, T1646, T1647, T1648, T1649, T1650, T1651 , T1653, T1654, T1655 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1610, T1611 and / or T1619, T1620 and / or T1632, T1633 and / or T1639, T1640 and / or T1648, T1649 can each be taken together to form a "heterocyclyl";
In so doing, optionally, T1446, T1447 may be taken together to form "heterocyclyl";
(3) "-C (Y8) NZ43Z44, -C (= NZ45) -Z46, -C (Y9) NZ47-Y10-Z48";
Y8, Y9, Y10 are then selected from the group consisting of “O, S, ═NH, ═NZ49” independently of each other;
In so doing, the radicals Z43, Z44, Z45, Z46, Z47, Z48, Z49 are selected independently of one another from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1656, -NT1657T1658, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1659, -C (O) O-T1660, -C (O) NH-T1661, -C (O) NT1662T1663, -O-T1664, -O (-T1665-O) _ry -H (ry = 1, 2, 3, 4, 5), -O (-T1666-O) _ry -T1667 (ry = 1, 2, 3, 4, 5), -OC (O) -T1668, -OC (O) -O-T1669, -OC (O) -NHT1670, -O-C (O)- NT1671T1672, -OP (O) (OT1673) (OT1674), -OSi (T1675) (T1676) (T1677), -OS (O ₂ ) -T1678, -NHC (O) -T1679, -NT1680C (O) -T1681, -NH-C (O) -O-T1682, -NH-C (O) -NH-T1683, -NH-C (O ) -NT1684T1685, -NT1686-C (O) -O-T1687, -NT1688-C (O) -NH-T1688, -NT1690-C (O) -NT1691T1692, -NHS (O ₂ ) -T1693, -NT1694S (O ₂ ) -T1695, -S-T1696, -S (O) -T1697, -S (O ₂ ) -T1698, -S (O ₂ ) NH-T1699, -S (O ₂ ) NT1700T1701, -S (O ₂ ) O-T1702, -P (O) (OT1703) (OT1704), -Si (T1705) (T1706) (T1707) ";
At that time, T1656, T1657, T1658, T1659, T1660, T1661, T1662, T1663, T1664, T1665, T1666, T1667, T1668, T1669, T1670, T1671, T1672, T1673, T1674, T1675, T1676, T1678, T1678, T1679, T1679 T1680, T1681, T1682, T1683, T1684, T1687, T1686, T1687, T1688, T1690, T1690, T1691, T1692, T1693, T1694, T1695, T1696, T1697, T1698, T1699, T1700, T1701, T1702, T1703 , T1705, T1706, and T1707 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1662, T1663 and / or T1671, T1672 and / or T1684, T1685 and / or T1691, T1692 and / or T1700, T1701 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1708, -NT1709T1710, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1711, -C (O) O-T1712, -C (O) NH-T1713, -C (O) NT1714T1715, -O-T1716, -O (-T1717-O) _rz -H (rz = 1, 2, 3, 4, 5), -O (-T1718-O) _rz -T1719 (rz = 1, 2, 3, 4, 5), -OC (O) -T1720, -OC (O) -O-T1721, -OC (O) -NHT1722, -O-C (O)- NT1723T1724, -OP (O) (OT1725) (OT1726), -OSi (T1727) (T1728) (T1729), -OS (O ₂ ) -T1730, -NHC (O) -T1731, -NT1732C (O) -T1733, -NH-C (O) -O-T1734, -NH-C (O) -NH-T1735, -NH-C (O ) -NT1736T1737, -NT1738-C (O) -O-T1739, -NT1740-C (O) -NH-T1741, -NT1742-C (O) -NT1743T1744, -NHS (O ₂ ) -T1745, -NT1746S (O ₂ ) -T1747, -S-T1748, -S (O) -T1749, -S (O ₂ ) -T1750, -S (O ₂ ) NH-T1751, -S (O ₂ ) NT1752T1753, -S (O ₂ ) O-T1754, -P (O) (OT1755) (OT1756), -Si (T1757) (T1758) (T1759) ";
At that time, T1708, T1709, T1710, T1711, T1712, T1713, T1714, T1715, T1716, T1717, T1718, T1719, T1720, T1721, T1722, T1723, T1724, T1725, T1726, T1727, T1728, T1729, T1730, T1731 , T1732, T1733, T1734, T1735, T1736, T1737, T1738, T1739, T1740, T1741, T1742, T1743, T1744, T1745, T1746, T1747, T1748, T1750, T1750, T1751, T1752, T1753, T1754, T1755 , T1757, T1758, T1759 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1714, T1715 and / or T1723, T1724 and / or T1736, T1737 and / or T1743, T1744 and / or T1752, T1753 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1760, -NT1761T1762, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1763, -C (O) O-T1764, -C (O) NH-T1765, -C (O) NT1766T1767, -O-T1768, -O (-T1769-O) _ra -H (ra = 1, 2, 3, 4, 5), -O (-T1770-O) _ra -T1771 (ra = 1, 2, 3, 4, 5), -OC (O) -T1772, -OC (O) -O-T1773, -OC (O) -NHT1774, -O-C (O)- NT1775T1776, -OP (O) (OT1777) (OT1778), -OSi (T1799) (T1780) (T1781), -OS (O ₂ ) -T1782, -NHC (O) -T1783, -NT1784C (O) -T1785, -NH-C (O) -O-T1786, -NH-C (O) -NH-T1787, -NH-C (O ) -NT1788T1789, -NT1790-C (O) -O-T1791, -NT1792-C (O) -NH-T1793, -NT1794-C (O) -NT1795T1796, -NHS (O ₂ ) -T1797, -NT1798S (O ₂ ) -T1799, -S-T1800, -S (O) -T1801, -S (O ₂ ) -T1802, -S (O ₂ ) NH-T1803, -S (O ₂ ) NT1804T1805, -S (O ₂ ) O-T1806, -P (O) (OT1807) (OT1808), -Si (T1809) (T1810) (T1811) ";
At that time, T1760, T1761, T1762, T1763, T1764, T1765, T1766, T1767, T1768, T1769, T1770, T1771, T1772, T1773, T1774, T1775, T1776, T1777, T1778, T1777, T1781, T1783, T1783, T1783 T1784, T1785, T1786, T1787, T1788, T1789, T1790, T1791, T1792, T1793, T1794, T1795, T1796, T1797, T1798, T1799, T1800, T1801, T1802, T1803, T1804, T1805, T1806, T1807, T1806, T1807 , T1809, T1810, T1811 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1766, T1767 and / or T1775, T1776 and / or T1788, T1789 and / or T1795, T1796 and / or T1804, T1805 may each be taken together to form a "heterocyclyl";
as well as
The groups Z3, Z4 are selected from the group consisting of:
(E) hydrogen;
(F) halogen, F, Cl, Br, I;
(G) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB457, -NB458B459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B460, -C (O) O-B461, -C (O) NH-B462, -C (O) NB463B464, -O-B465, -O (-B466-O) _x -H (x = 1, 2, 3, 4, 5), -O (-B467-O) _x -B468 (x = 1, 2, 3, 4, 5), -OC (O) -B469, -OC (O) -O-B470, -OC (O) -NHB471, -O-C (O)- NB472B473, -OP (O) (OB474) (OB475), -OSi (B476) (B477) (B478), -OS (O ₂ ) -B479, -NHC (O) -B480, -NB481C (O) -B482, -NH-C (O) -O-B483, -NH-C (O) -NH-B484, -NH-C (O ) -NB485B486, -NB487-C (O) -O-B488, -NB489-C (O) -NH-B490, -NB491-C (O) -NB492B493, -NHS (O ₂ ) -B494, -NB495S (O ₂ ) -B496, -S-B497, -S (O) -B498, -S (O ₂ ) -B499, -S (O ₂ ) NH-B500, -S (O ₂ ) NB501B502, -S (O ₂ ) O-B503, -P (O) (OB504) (OB505), -Si (B506) (B507) (B508) ";
At that time, B457, B458, B459, B460, B461, B462, B463, B464, B465, B466, B467, B468, B469, B470, B471, B472, B473, B474, B475, B476, B477, B478, B480 B481, B482, B483, B484, B485, B486, B487, B488, B489, B490, B491, B492, B493, B494, B495, B496, B497, B498, B499, B500, B501, B502, B503, B504, B504 , B506, B507, B508 are independently of each other "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B463, B464 and / or B472, B473 and / or B485, B486 and / or B492, B493 and / or B501, B502 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB509, -NB510B511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B512, -C (O) O-B513, -C (O) NH-B514, -C (O) NB515B516, -O-B517, -O (-B518-O) _y -H (y = 1, 2, 3, 4, 5), -O (-B519-O) _y -B520 (y = 1, 2, 3, 4, 5), -OC (O) -B521, -OC (O) -O-B522, -OC (O) -NHB523, -O-C (O)- NB524B525, -OP (O) (OB526) (OB527), -OSi (B528) (B529) (B530), -OS (O ₂ ) -B531, -NHC (O) -B532, -NB533C (O) -B534, -NH-C (O) -O-B535, -NH-C (O) -NH-B536, -NH-C (O ) -NB537B538, -NB539-C (O) -O-B540, -NB541-C (O) -NH-B542, -NB543-C (O) -NB544B545, -NHS (O ₂ ) -B546, -NB547S (O ₂ ) -B548, -S-B549, -S (O) -B550, -S (O ₂ ) -B551, -S (O ₂ ) NH-B552, -S (O ₂ ) NB553B554, -S (O ₂ ) O-B555, -P (O) (OB556) (OB557), -Si (B558) (B559) (B560) ";
At that time, B509, B510, B511, B512, B513, B514, B515, B516, B517, B518, B519, B520, B521, B522, B523, B524, B525, B526, B527, B528, B529, B530, B531, B532 B533, B534, B535, B536, B537, B538, B539, B540, B541, B542, B543, B544, B545, B546, B547, B548, B549, B550, B551, B552, B553, B554, B555, B556, B555, B556 , B558, B559, B560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B515, B516 and / or B524, B525 and / or B537, B538 and / or B544, B545 and / or B553, B554 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB561, -NB562B563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B564, -C (O) O-B565, -C (O) NH-B566, -C (O) NB567B568, -O-B569, -O (-B570-O) _z -H (z = 1, 2, 3, 4, 5), -O (-B571-O) _z -B572 (z = 1, 2, 3, 4, 5), -OC (O) -B573, -OC (O) -O-B574, -OC (O) -NHB575, -O-C (O)- NB576B577, -OP (O) (OB578) (OB579), -OSi (B580) (B581) (B582), -OS (O ₂ ) -B583, -NHC (O) -B584, -NB585C (O) -B586, -NH-C (O) -O-B587, -NH-C (O) -NH-B588, -NH-C (O ) -NB589B590, -NB591-C (O) -O-B592, -NB593-C (O) -NH-B594, -NB595-C (O) -NB596B597, -NHS (O ₂ ) -B598, -NB599S (O ₂ ) -B600, -S-B601, -S (O) -B602, -S (O ₂ ) -B603, -S (O ₂ ) NH-B604, -S (O ₂ ) NB605B606, -S (O ₂ ) O-B607, -P (O) (OB608) (OB609), -Si (B610) (B611) (B612) ";
At that time, B561, B562, B563, B564, B565, B566, B567, B568, B569, B570, B571, B572, B573, B574, B575, B576, B577, B578, B579, B580, B581, B582, B58, B58 , B585, B586, B587, B588, B589, B590, B591, B592, B593, B594, B595, B596, B597, B598, B599, B600, B601, B602, B603, B604, B605, B606, B607, B608, B607 , B610, B611, B612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B567, B568 and / or B576, B577 and / or B589, B590 and / or B596, B597 and / or B605, B606 may each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB613, -NB614B615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B616, -C (O) O-B617, -C (O) NH-B618, -C (O) NB619B620, -O-B621, -O (-B622-O) _a -H (a = 1, 2, 3, 4, 5), -O (-B623-O) _a -B624 (a = 1, 2, 3, 4, 5), -OC (O) -B625, -OC (O) -O-B626, -OC (O) -NHB627, -O-C (O)- NB628B629, -OP (O) (OB630) (OB631), -OSi (B632) (B633) (B634), -OS (O ₂ ) -B635, -NHC (O) -B636, -NB637C (O) -B638, -NH-C (O) -O-B639, -NH-C (O) -NH-B640, -NH-C (O ) -NB641B642, -NB643-C (O) -O-B644, -NB645-C (O) -NH-B646, -NB647-C (O) -NB648B649, -NHS (O ₂ ) -B650, -NB651S (O ₂ ) -B652, -S-B653, -S (O) -B654, -S (O ₂ ) -B655, -S (O ₂ ) NH-B656, -S (O ₂ ) NB657B658, -S (O ₂ ) O-B659, -P (O) (OB660) (OB661), -Si (B662) (B663) (B664) ";
At that time, B613, B614, B615, B616, B617, B618, B619, B620, B621, B622, B623, B624, B625, B626, B627, B628, B629, B630, B631, B632, B633, B634, B635, B636 , B637, B638, B639, B640, B641, B642, B643, B644, B645, B646, B647, B648, B649, B650, B651, B652, B653, B654, B655, B656, B657, B658, B659, B660, B659, B660 , B662, B663, B664 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B619, B620 and / or B628, B629 and / or B641, B642 and / or B648, B649 and / or B657, B658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB665, -NB666B667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B668, -C (O) O-B669, -C (O) NH-B670, -C (O) NB671B672, -O-B673, -O (-B674-O) _b -H (b = 1, 2, 3, 4, 5), -O (-B675-O) _b -B676 (b = 1, 2, 3, 4, 5), -OC (O) -B677, -OC (O) -O-B678, -OC (O) -NHB679, -O-C (O)- NB680B681, -OP (O) (OB682) (OB683), -OSi (B684) (B685) (B686), -OS (O ₂ ) -B687, -NHC (O) -B688, -NB689C (O) -B690, -NH-C (O) -O-B691, -NH-C (O) -NH-B692, -NH-C (O ) -NB693B694, -NB695-C (O) -O-B696, -NB697-C (O) -NH-B698, -NB699-C (O) -NB700B701, -NHS (O ₂ ) -B702, -NB703S (O ₂ ) -B704, -S-B705, -S (O) -B706, -S (O ₂ ) -B707, -S (O ₂ ) NH-B708, -S (O ₂ ) NB709B710, -S (O ₂ ) O-B711, -P (O) (OB712) (OB713), -Si (B714) (B715) (B716) ";
At that time, B665, B666, B667, B668, B669, B670, B671, B672, B673, B674, B675, B676, B677, B678, B679, B680, B681, B682, B683, B684, B685, B686, B687 B689, B690, B691, B692, B693, B694, B695, B696, B697, B698, B699, B700, B701, B702, B703, B704, B705, B706, B707, B708, B709, B710, B711, B712 , B714, B715, B716 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B671, B672 and / or B680, B681 and / or B693, B694 and / or B700, B701 and / or B709, B710 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB717, -NB718B719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B720, -C (O) O-B721, -C (O) NH-B722, -C (O) NB723B724, -O-B725, -O (-B726-O) _c -H (c = 1, 2, 3, 4, 5), -O (-B727-O) _c -B728 (c = 1, 2, 3, 4, 5), -OC (O) -B729, -OC (O) -O-B730, -OC (O) -NHB731, -O-C (O)- NB732B733, -OP (O) (OB734) (OB735), -OSi (B736) (B737) (B738), -OS (O ₂ ) -B739, -NHC (O) -B740, -NB741C (O) -B742, -NH-C (O) -O-B743, -NH-C (O) -NH-B744, -NH-C (O ) -NB745B746, -NB747-C (O) -O-B748, -NB749-C (O) -NH-B750, -NB751-C (O) -NB752B753, -NHS (O ₂ ) -B754, -NB755S (O ₂ ) -B756, -S-B757, -S (O) -B758, -S (O ₂ ) -B759, -S (O ₂ ) NH-B760, -S (O ₂ ) NB761B762, -S (O ₂ ) O-B763, -P (O) (OB764) (OB765), -Si (B766) (B767) (B768) ";
At that time, B717, B718, B719, B720, B721, B722, B723, B724, B725, B726, B727, B728, B729, B730, B731, B732, B733, B734, B735, B736, B737, B738, B739, B740 , B741, B742, B743, B744, B745, B746, B747, B748, B749, B750, B751, B752, B753, B754, B755, B756, B757, B758, B759, B760, B761, B762, B763, B764 , B766, B767, B768 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B723, B724 and / or B732, B733 and / or B745, B746 and / or B752, B753 and / or B761, B762 may each be taken together to form a "heterocyclyl";
(J) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB769, -NB770B771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B772, -C (O) O-B773, -C (O) NH-B774, -C (O) NB775B776, -O-B777, -O (-B778-O). _d -H (d = 1, 2, 3, 4, 5), -O (-B779-O) _d -B780 (d = 1, 2, 3, 4, 5), -OC (O) -B781, -OC (O) -O-B782, -OC (O) -NHB783, -O-C (O)- NB784B785, -OP (O) (OB786) (OB787), -OSi (B788) (B789) (B790), -OS (O ₂ ) -B791, -NHC (O) -B792, -NB793C (O) -B794, -NH-C (O) -O-B795, -NH-C (O) -NH-B796, -NH-C (O ) -NB797B798, -NB799-C (O) -O-B800, -NB801-C (O) -NH-B802, -NB803-C (O) -NB804B805, -NHS (O ₂ ) -B806, -NB807S (O ₂ ) -B808, -S-B809, -S (O) -B810, -S (O ₂ ) -B811, -S (O ₂ ) NH-B812, -S (O ₂ ) NB813B814, -S (O ₂ ) O-B815, -P (O) (OB816) (OB817), -Si (B818) (B819) (B820) ";
At that time, B769, B770, B771, B772, B773, B774, B775, B776, B777, B778, B779, B780, B781, B782, B783, B784, B785, B786, B787, B788, B789, B790, B791, 792 B793, B794, B795, B796, B797, B798, B799, B800, B801, B802, B803, B804, B805, B806, B807, B808, B809, B810, B811, B812, B813, B814, B815, B816, B815, B816 , B818, B819, B820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B775, B776 and / or B784, B785 and / or B797, B798 and / or B804, B805 and / or B813, B814 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB821, -NB822B823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B824, -C (O) O-B825, -C (O) NH-B826, -C (O) NB827B828, -O-B829, -O (-B830-O) _e -H (e = 1, 2, 3, 4, 5), -O (-B831-O) _e -B832 (e = 1, 2, 3, 4, 5), -OC (O) -B833, -OC (O) -O-B834, -OC (O) -NHB835, -O-C (O)- NB836B837, -OP (O) (OB838) (OB839), -OSi (B840) (B841) (B842), -OS (O ₂ ) -B843, -NHC (O) -B844, -NB845C (O) -B846, -NH-C (O) -O-B847, -NH-C (O) -NH-B848, -NH-C (O ) -NB849B850, -NB851-C (O) -O-B852, -NB853-C (O) -NH-B854, -NB855-C (O) -NB856B857, -NHS (O ₂ ) -B858, -NB859S (O ₂ ) -B860, -S-B861, -S (O) -B862, -S (O ₂ ) -B863, -S (O ₂ ) NH-B864, -S (O ₂ ) NB865B866, -S (O ₂ ) O-B867, -P (O) (OB868) (OB869), -Si (B870) (B871) (B872) ";
At that time, B821, B822, B823, B824, B825, B826, B827, B828, B829, B830, B831, B832, B833, B834, B835, B836, B837, B838, B839, B840, B841, B842, B844 B845, B846, B847, B848, B849, B850, B851, B852, B853, B854, B855, B856, B857, B858, B859, B860, B861, B862, B863, B864, B865, B866, B867, 86 , B870, B871, B872 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B827, B828 and / or B836, B837 and / or B849, B850 and / or B856, B857 and / or B865, B866 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB873, -NB874B875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B876, -C (O) O-B877, -C (O) NH-B878, -C (O) NB879B880, -O-B881, -O (-B882-O) _f -H (f = 1, 2, 3, 4, 5), -O (-B883-O) _f -B884 (f = 1, 2, 3, 4, 5), -OC (O) -B885, -OC (O) -O-B886, -OC (O) -NHB887, -O-C (O)- NB888B889, -OP (O) (OB890) (OB891), -OSi (B892) (B893) (B894), -OS (O ₂ ) -B895, -NHC (O) -B896, -NB897C (O) -B898, -NH-C (O) -O-B899, -NH-C (O) -NH-B900, -NH-C (O ) -NB901B902, -NB903-C (O) -O-B904, -NB905-C (O) -NH-B906, -NB907-C (O) -NB908B909, -NHS (O ₂ ) -B910, -NB911S (O ₂ ) -B912, -S-B913, -S (O) -B914, -S (O ₂ ) -B915, -S (O ₂ ) NH-B916, -S (O ₂ ) NB917B918, -S (O ₂ ) O-B919, -P (O) (OB920) (OB921), -Si (B922) (B923) (B924) ";
In that case, B873, B874, B875, B876, B877, B878, B879, B880, B881, B882, B883, B884, B885, B886, B887, B888, B889, B890, B891, B892, B893, B894, B895, B896 , B897, B898, B899, B900, B901, B902, B903, B904, B905, B906, B907, B908, B909, B910, B911, B912, B913, B914, B915, B916, B917, B918, B919, B920 , B922, B923, B924 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B879, B880 and / or B888, B889 and / or B901, B902 and / or B908, B909 and / or B917, B918 may each be taken together to form a "heterocyclyl";
(K) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB925, -NB926B927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B928, -C (O) O-B929, -C (O) NH-B930, -C (O) NB931B932, -O-B933, -O (-B934-O) _g -H (g = 1, 2, 3, 4, 5), -O (-B935-O) _g -B936 (g = 1, 2, 3, 4, 5), -OC (O) -B937, -OC (O) -O-B938, -OC (O) -NHB939, -O-C (O)- NB940B941, -OP (O) (OB942) (OB943), -OSi (B944) (B945) (B946), -OS (O ₂ ) -B947, -NHC (O) -B948, -NB949C (O) -B950, -NH-C (O) -O-B951, -NH-C (O) -NH-B952, -NH-C (O ) -NB953B954, -NB955-C (O) -O-B956, -NB957-C (O) -NH-B958, -NB959-C (O) -NB960B961, -NHS (O ₂ ) -B962, -NB963S (O ₂ ) -B964, -S-B965, -S (O) -B966, -S (O ₂ ) -B967, -S (O ₂ ) NH-B968, -S (O ₂ ) NB969B970, -S (O ₂ ) O-B971, -P (O) (OB972) (OB973), -Si (B974) (B975) (B976) ";
In that case, B925, B926, B927, B928, B929, B930, B931, B932, B933, B934, B935, B936, B937, B938, B939, B940, B941, B942, B943, B944, B945, B946, B947, B948 B949, B950, B951, B952, B953, B954, B955, B956, B957, B958, B959, B960, B961, B962, B963, B964, B965, B966, B967, B968, B969, B970, B971, B972 , B974, B975, B976 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B931, B932 and / or B940, B941 and / or B953, B954 and / or B960, B961 and / or B969, B970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB977, -NB978B979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B980, -C (O) O-B981, -C (O) NH-B982, -C (O) NB983B984, -O-B985, -O (-B986-O) _h -H (h = 1, 2, 3, 4, 5), -O (-B987-O) _h -B988 (h = 1, 2, 3, 4, 5), -OC (O) -B989, -OC (O) -O-B990, -OC (O) -NHB991, -O-C (O)- NB992B993, -OP (O) (OB994) (OB995), -OSi (B996) (B997) (B998), -OS (O ₂ ) -B999, -NHC (O) -B1000, -NB1001C (O) -B1002, -NH-C (O) -O-B1003, -NH-C (O) -NH-B1004, -NH-C (O ) -NB1005B1006, -NB1007-C (O) -O-B1008, -NB1009-C (O) -NH-B1010, -NB1011-C (O) -NB1012B1013, -NHS (O ₂ ) -B1014, -NB1015S (O ₂ ) -B1016, -S-B1017, -S (O) -B1018, -S (O ₂ ) -B1019, -S (O ₂ ) NH-B1020, -S (O ₂ ) NB1021B1022, -S (O ₂ ) O-B1023, -P (O) (OB1024) (OB1025), -Si (B1026) (B1027) (B1028) ";
At that time, B977, B978, B979, B980, B981, B982, B983, B984, B985, B986, B987, B988, B989, B990, B991, B992, B993, B994, B995, B996, B997, B998, B999, B999 , B1001, B1002, B1003, B1004, B1005, B1006, B1007, B1008, B1009, B1010, B1011, B1012, B1013, B1014, B1015, B1016, B1017, B1018, B1019, B1020, B1021, B1022, B1023, B1024 , B1026, B1027, B1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B983, B984 and / or B992, B993 and / or B1005, B1006 and / or B1012, B1013 and / or B1021, B1022 may each be taken together to form a "heterocyclyl";
(L) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1029, -NB1030B1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1032, -C (O) O-B1033, -C (O) NH-B1034, -C (O) NB1035B1036, -O-B1037, -O (-B1038-O) _i -H (i = 1, 2, 3, 4, 5), -O (-B1039-O) _i -B1040 (i = 1, 2, 3, 4, 5), -OC (O) -B1041, -OC (O) -O-B1042, -OC (O) -NHB1043, -O-C (O)- NB1044B1045, -OP (O) (OB1046) (OB1047), -OSi (B1048) (B1049) (B1050), -OS (O ₂ ) -B1051, -NHC (O) -B1052, -NB1053C (O) -B1054, -NH-C (O) -O-B1055, -NH-C (O) -NH-B1056, -NH-C (O ) -NB1057B1058, -NB1059-C (O) -O-B1060, -NB1061-C (O) -NH-B1062, -NB1063-C (O) -NB1064B1065, -NHS (O ₂ ) -B1066, -NB1067S (O ₂ ) -B1068, -S-B1069, -S (O) -B1070, -S (O ₂ ) -B1071, -S (O ₂ ) NH-B1072, -S (O ₂ ) NB1073B1074, -S (O ₂ ) O-B1075, -P (O) (OB1076) (OB1077), -Si (B1078) (B1079) (B1080) ";
At that time, B1029, B1030, B1031, B1032, B1033, B1034, B1035, B1036, B1037, B1038, B1039, B1040, B1041, B1042, B1043, B1044, B1045, B1046, B1047, B1048, B1049, B1050, B1051, B105, , B1053, B1054, B1055, B1056, B1057, B1058, B1059, B1060, B1061, B1062, B1063, B1064, B1065, B1066, B1067, B1068, B1069, B1070, B1071, B1072, B1073, B1074, B1075, B1076 , B1078, B1079, B1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1035, B1036 and / or B1044, B1045 and / or B1057, B1058 and / or B1064, B1065 and / or B1073, B1074 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1081, -NB1082B1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1084, -C (O) O-B1085, -C (O) NH-B1086, -C (O) NB1087B1088, -O-B1089, -O (-B1090-O) _j -H (j = 1, 2, 3, 4, 5), -O (-B1091-O) _j -B1092 (j = 1, 2, 3, 4, 5), -OC (O) -B1093, -OC (O) -O-B1094, -OC (O) -NHB1095, -O-C (O)- NB1096B1097, -OP (O) (OB1098) (OB1099), -OSi (B1100) (B1101) (B1102), -OS (O ₂ ) -B1103, -NHC (O) -B1104, -NB1105C (O) -B1106, -NH-C (O) -O-B1107, -NH-C (O) -NH-B1108, -NH-C (O ) -NB1109B1110, -NB1111-C (O) -O-B1112, -NB1113-C (O) -NH-B1114, -NB1115-C (O) -NB1116B1117, -NHS (O ₂ ) -B1118, -NB1119S (O ₂ ) -B1120, -S-B1121, -S (O) -B1122, -S (O ₂ ) -B1123, -S (O ₂ ) NH-B1124, -S (O ₂ ) NB1125B1126, -S (O ₂ ) O-B1127, -P (O) (OB1128) (OB1129), -Si (B1130) (B1131) (B1132) ";
At that time, B1081, B1082, B1083, B1084, B1085, B1086, B1087, B1088, B1089, B1090, B1091, B1092, B1093, B1094, B1095, B1096, B1097, B1098, B1099, B1100, B1101, B1102, B1103, B1104 , B1105, B1106, B1107, B1108, B1109, B1110, B1111, B1112, B1113, B1114, B1115, B1116, B1117, B1118, B1119, B1120, B1121, B1122, B1123, B1124, B1125, B1126, B1127, B1128 , B1130, B1131, and B1132, independently of one another, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1087, B1088 and / or B1096, B1097 and / or B1109, B1110 and / or B1116, B1117 and / or B1125, B1126 may each be taken together to form a "heterocyclyl";
(M) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -B1133, -C (O) O-B1134, -C (O)- NB1135B1136, -S (O ₂ ) -B1137, -S (O ₂ ) O-B1138 ";
In this case, B1133, B1134, B1135, B1136, B1137, B1138 are independent of each other as “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, B1135, B1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1139, -NB1140B1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1142, -C (O) O-B1143, -C (O) NH-B1144, -C (O) NB1145B1146, -O-B1147, -O (-B1148-O). _k -H (k = 1, 2, 3, 4, 5), -O (-B1149-O) _k -B1150 (k = 1, 2, 3, 4, 5), -OC (O) -B1151, -OC (O) -O-B1152, -OC (O) -NHB1153, -O-C (O)- NB1154B1155, -OP (O) (OB1156) (OB1157), -OSi (B1158) (B1159) (B1160), -OS (O ₂ ) -B1161, -NHC (O) -B1162, -NB1163C (O) -B1164, -NH-C (O) -O-B1165, -NH-C (O) -NH-B1166, -NH-C (O ) -NB1167B1168, -NB1169-C (O) -O-B1170, -NB1171-C (O) -NH-B1172, -NB1173-C (O) -NB1174B1175, -NHS (O ₂ ) -B1176, -NB1177S (O ₂ ) -B1178, -S-B1179, -S (O) -B1180, -S (O ₂ ) -B1181, -S (O ₂ ) NH-B1182, -S (O ₂ ) NB1183B1184, -S (O ₂ ) O-B1185, -P (O) (OB1186) (OB1187), -Si (B1188) (B1189) (B1190) ";
At that time, B1139, B1140, B1141, B1142, B1143, B1144, B1145, B1146, B1147, B1148, B1149, B1150, B1151, B1152, B1153, B1154, B1155, B1156, B1157, B1158, B1159, B1160, B1161, B1162 , B1163, B1164, B1165, B1166, B1167, B1168, B1169, B1170, B1171, B1172, B1173, B1174, B1175, B1176, B1177, B1178, B1179, B1180, B1181, B1182, B1183, B1186, B1185, B1186, B1185, B1186 , B1188, B1189, B1190 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1145, B1146 and / or B1154, B1155 and / or B1167, B1168 and / or B1174, B1175 and / or B1183, B1184 can also be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1191, -NB1192B1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1194, -C (O) O-B1195, -C (O) NH-B1196, -C (O) NB1197B1198, -O-B1199, -O (-B1200-O). _l -H (l = 1, 2, 3, 4, 5), -O (-B1201-O) _l -B1202 (l = 1, 2, 3, 4, 5), -OC (O) -B1203, -OC (O) -O-B1204, -OC (O) -NHB1205, -O-C (O)- NB1206B1207, -OP (O) (OB1208) (OB1209), -OSi (B1210) (B1211) (B1212), -OS (O ₂ ) -B1213, -NHC (O) -B1214, -NB1215C (O) -B1216, -NH-C (O) -O-B1217, -NH-C (O) -NH-B1218, -NH-C (O ) -NB1219B1220, -NB1221-C (O) -O-B1222, -NB1223-C (O) -NH-B1224, -NB1225-C (O) -NB1226B1227, -NHS (O ₂ ) -B1228, -NB1229S (O ₂ ) -B1230, -S-B1231, -S (O) -B1232, -S (O ₂ ) -B1233, -S (O ₂ ) NH-B1234, -S (O ₂ ) NB1235B1236, -S (O ₂ ) O-B1237, -P (O) (OB1238) (OB1239), -Si (B1240) (B1241) (B1242) ";
At that time, B1191, B1192, B1193, B1194, B1195, B1196, B1197, B1198, B1199, B1200, B1201, B1202, B1203, B1204, B1205, B1206, B1207, B1208, B1209, B1210, B1211, B1212, B1213, B12 , B1215, B1216, B1217, B1218, B1219, B1220, B1221, B1222, B1223, B1224, B1225, B1226, B1227, B1228, B1229, B1230, B1231, B1232, B1233, B1234, B1235, B1236, B1237, B1238 , B1240, B1241, B1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1197, B1198 and / or B1206, B1207 and / or B1219, B1220 and / or B1226, B1227 and / or B1235, B1236 may each be taken together to form a "heterocyclyl";
as well as
The group Z5 is independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHD1, -ND2D3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -D4, -C (O) O-D5, -C (O) NH-D6, -C (O) ND7D8, -O-D9, -O (-D10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-D11-O) _r -D12 (r = 1, 2, 3, 4, 5), -OC (O) -D13, -OC (O) -OD14, -OC (O) -NHD15, -O-C (O)- ND16D17, -OP (O) (OD18) (OD19), -OSi (D20) (D21) (D22), -OS (O ₂ ) -D23, -NHC (O) -D24, -ND25C (O) -D26, -NH-C (O) -O-D27, -NH-C (O) -NH-D28, -NH-C (O ) -ND29D30, -ND31-C (O) -O-D32, -ND33-C (O) -NH-D34, -ND35-C (O) -ND36D37, -NHS (O ₂ ) -D38, -ND39S (O ₂ ) -D40, -S-D41, -S (O) -D42, -S (O ₂ ) -D43, -S (O ₂ ) NH-D44, -S (O ₂ ) ND45D46, -S (O ₂ ) O-D47, -P (O) (OD48) (OD49), -Si (D50) (D51) (D52) ";
At that time, D1, D2, D3, D4, D5, D6, D7, D8, D9, D10, D11, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24 D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, D44, D45, D46, D47, D48, D49 , D50, D51, D52 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally D7, D8 and / or D16, D17 and / or D29, D30 and / or D36, D37 and / or D45, D46 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHD53, -ND54D55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -D56, -C (O) O-D57, -C (O) NH-D58, -C (O) ND59D60, -O-D61, -O (-D62-O) _t -H (t = 1, 2, 3, 4, 5), -O (-D63-O) _t -D64 (t = 1, 2, 3, 4, 5), -OC (O) -D65, -OC (O) -O-D66, -OC (O) -NHD67, -O-C (O)- ND68D69, -OP (O) (OD70) (OD71), -OSi (D72) (D73) (D74), -OS (O ₂ ) -D75, -NHC (O) -D76, -ND77C (O) -D78, -NH-C (O) -O-D79, -NH-C (O) -NH-D80, -NH-C (O ) -ND81D82, -ND83-C (O) -O-D84, -ND85-C (O) -NH-D86, -ND87-C (O) -ND88D89, -NHS (O ₂ ) -D90, -ND91S (O ₂ ) -D92, -S-D93, -S (O) -D94, -S (O ₂ ) -D95, -S (O ₂ ) NH-D96, -S (O ₂ ) ND97D98, -S (O ₂ ) O-D99, -P (O) (OD100) (OD101), -Si (D102) (D103) (D104) ";
At that time, D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, D75, D76 D77, D78, D79, D80, D81, D82, D83, D84, D85, D86, D87, D88, D89, D90, D91, D92, D93, D94, D95, D96, D97, D98, D99, D100, D101 , D102, D103, D104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally D59, D60 and / or D68, D69 and / or D81, D82 and / or D88, D89 and / or D97, D98 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHD105, -ND106D107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -D108, -C (O) O-D109, -C (O) NH-D110, -C (O) ND111D112, -O-D113, -O (-D114-O) _t -H (t = 1, 2, 3, 4, 5), -O (-D115-O) _t -D116 (t = 1, 2, 3, 4, 5), -OC (O) -D117, -OC (O) -O-D118, -OC (O) -NHD119, -O-C (O)- ND120D121, -OP (O) (OD122) (OD123), -OSi (D124) (D125) (D126), -OS (O ₂ ) -D127, -NHC (O) -D128, -ND129C (O) -D130, -NH-C (O) -O-D131, -NH-C (O) -NH-D132, -NH-C (O ) -ND133D134, -ND135-C (O) -O-D136, -ND137-C (O) -NH-D138, -ND139-C (O) -ND140D141, -NHS (O ₂ ) -D142, -ND143S (O ₂ ) -D144, -S-D145, -S (O) -D146, -S (O ₂ ) -D147, -S (O ₂ ) NH-D148, -S (O ₂ ) ND149D150, -S (O ₂ ) O-D151, -P (O) (OD152) (OD153), -Si (D154) (D155) (D156) ";
At that time, D105, D106, D107, D108, D109, D110, D111, D112, D113, D114, D115, D116, D117, D118, D119, D120, D121, D122, D123, D124, D125, D126, D127, D128 , D129, D130, D131, D132, D133, D134, D135, D136, D137, D138, D139, D140, D141, D142, D143, D144, D145, D146, D147, D148, D149, D150, D151, D152, D153 , D154, D155, D156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally D111, D112 and / or D120, D121 and / or D133, D134 and / or D140, D141 and / or D149, D150 can each be combined to form a “heterocyclyl”] to form a novel compound from a series of pyrido [2,3-b] pyrazines Describe.

In order to avoid ambiguity, the cases (A) to (E) above for general formula (I) are described below:
According to the case of (A), the novel pyrido [2,3-b] pyrazine derivative may be substituted at its at least one Z3, Z4 group by a “substituted aryl”, in which case Novelty is given either by the lower case (a) or the lower case (c). Where only one of the groups Z3, Z4 is a novel "substituted aryl", each of the other groups Z3, Z4 may optionally be substituted within the maximum range expressed [("and "Is a connection to the lower (d) case." Optionally, both groups Z3, Z4 may additionally and still be further substituted [lower (b) or (d In the case of)] The radicals Z1, Z2 and Z5 are optionally substituted in the maximum range expressed ["and" are connections to cases (A) to (D)].

  According to the case of (B), the new pyrido [2,3-b] pyrazine derivative may be substituted in its at least one Z3, Z4 group by a “substituted heteroaryl”, Novelty is given either by the lower case (a) or the lower case (c). Where only one of the groups Z3, Z4 is a novel "substituted heteroaryl", each of the other groups Z3, Z4 may optionally be substituted within the maximum range expressed [(" And "is a connection to the lower (d) case.] Optionally, both groups Z3, Z4 may additionally and still be further substituted [lower (b) or ( In the case of d)] The radicals Z1, Z2 and Z5 are optionally substituted in the maximum range expressed ["and" are connections to cases (A) to (D)].

According to the case of (C), the novel pyrido [2,3-b] pyrazine derivatives are represented by “substituted alkyl” or “C ₉ -C ₃₀ -alkyl” in at least one Z 3, Z 4 group. It may be newly replaced. When only one of the radicals Z3, Z4 is a new “substituted alkyl” or “C ₉ -C ₃₀ -alkyl”, the other radicals Z3, Z4, respectively, can optionally be represented in the maximum range represented. maximum range groups Z1, Z2 and Z5 are optionally expressed - may be substituted [a connection to the case of "alkyl C ₉ -C _30" ( "and", the lower the in. ["And" are connections to cases (A) through (D)].

  According to the case of (D), the novel pyrido [2,3-b] pyrazine derivative may be substituted by “—NZ10Z11, —OZ12, —SZ13” in at least one Z3, Z4 group thereof, At that time, novelty is given by either the lower case (a) or the lower case (b). When only one of the groups Z3, Z4 is a novel "-NZ10Z11, -OZ12, -SZ13", the other group Z3, Z4, respectively, may be optionally substituted in the maximum range expressed. [("And" are connections to the lower case (b)]. The groups Z1, Z2 and Z5 are optionally substituted in the maximum range expressed ["and" Connection to the case of A) to (D)].

  According to the case of (E), the novel pyrido [2,3-b] pyrazine derivative may be substituted at its at least one Z3, Z4 group by “—NZ24Z25, —NZ26Z27”, In the case of the lower order (a) (1), the lower order (b) (1) (I), the lower order (b) (1) (II), the lower order (b ) Novelty is given by either of the cases (2). When only one of the groups Z1, Z2 is the new "-NZ24Z25, -NZ26Z27", each of the other groups Z1, Z2 can optionally be represented by a maximum range [subordinate (c), (d ))] [("And" are connections to the lower case (b) (2)]. The groups Z3, Z4 and Z5 are optionally the largest represented. Replaced in range ["and" are connections to case (d) below it]].

In one preferred embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (A)
The group Z1 is independently “NZ14Z15”, where Z14 is hydrogen or “aryl” and Z15 is “—C (O) NH-alkyl”; (O) NH-alkyl "may additionally be optionally substituted by" -OH ";
The group Z2 is independently hydrogen;
The group Z3 is independently “substituted aryl”, wherein the “substituted aryl” is substituted by at least one substituent selected from the group consisting of the following, which are the same or different: ing:
(A) "alkyl, -OC (O) -alkyl, -O-alkyl, -NHC (O) -alkyl";
However, said substituents of the substituent group (a) are further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other:
(I) "aryl, heterocyclyl, -O-alkyl-O-alkyl, -O-arylalkyl";
Or
The group Z3 is independently “substituted aryl”, wherein the “substituted aryl” is substituted by at least one substituent selected from the group consisting of the following, which are the same or different: ing:
(C) "-OC (O) -O-alkyl, -OC (O) -O-aryl, -OC (O) -N (alkyl) ₂ , -OC (O) -NH-alkyl, -OC (O ) -C ₉ -C ₃₀ - alkyl, -NHC (O) -O- alkyl, -NHC (O) -NH- alkyl, -NHC (O) -N (alkyl) _2, -Si (alkyl) ₃ ";
In this case, the said substituents of the substituent group (c) may optionally be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "-O-alkyl, -O-arylalkyl";
In that case, the group Z3 may optionally be further substituted with at least one substituent, independently of one another, selected from the group consisting of:
(D) "halogen, F, Cl, Br, I, -O-alkyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (A)
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl, —NHC (O) NH-butyl-OH”;
The group Z2 is independently hydrogen;
The radicals Z3 are independent of each other, “carbonic acid-4-phenyl-ester-methyl-ester, carbonic acid-3-phenyl-ester-2-methoxy-ethyl-ester, carbonic acid-4-phenyl-ester-2-methoxy-ethyl. -Ester, carbonic acid-4-phenyl-ester-phenyl-ester, N-diethyl-carbamic acid-4-phenyl-ester, 3-phenyl-acrylic acid-4-phenyl-ester, nonadecanoic acid-4-phenyl-ester, Carbonic acid-4-phenyl-ester-isobutyl-ester, carbonic acid-4-phenyl-ester-but-2-ynyl-ester, N-dimethyl-carbamic acid-4-phenyl-ester, N-ethyl-carbamic acid-4- Phenyl-ester, N- (4-phenyl) -carbamic acid-t-butyl-ester, N- (4 -Phenyl) -carbamic acid-2-methoxy-ethyl-ester, 4- (3-ethyl-urea) phenyl, 4- (3,3-methyl-urea) phenyl, 4-morpholin-4-ylmethyl-phenyl, 4 -[2- (2-methoxy-ethoxy) -ethoxy] -phenyl, N- (4-phenyl) -2- (2-methoxy-ethoxy) -acetamide, carbonic acid-4- (2-methoxy) phenyl-ester 2-methoxy-ethyl-ester, carbonic acid-4-phenyl-ester-2-benzyloxy-ethyl-ester, carbonic acid-4- (2-methoxy) phenyl-ester-2-benzyloxy-ethyl-ester, N- ( 4-phenyl) -2-benzyloxy-acetamide, 3-trimethylsilanyl-phenyl, N-diethyl-carbamic acid-4- (2-methoxy) ) Phenyl-ester, N-diethyl-carbamic acid-4- (2-chloro-6-methoxy) -phenyl-ester, carbonic acid-4- (2-methoxy) -phenyl-ester-2- [2- (2- Selected from the group consisting of "methoxy-ethoxy) -ethoxy] -ethyl-esters";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (B)
The group Z1 is independently “NZ14Z15”, wherein Z14 is hydrogen and Z15 is “—C (O) NH-alkyl”;
The group Z2 is independently hydrogen;
The group Z3 is, independently, “substituted heteroaryl”, wherein “substituted heteroaryl” is the same or different by at least one substituent selected from the group consisting of: Has been replaced:
(A) "-NHC (O) -NH-alkyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (B)
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl”;
The group Z2 is independently hydrogen;
The group Z3, independently of one another, is selected from the group consisting of “6- (3-ethyl-urea) -pyridin-3-yl”;
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (C)
The group Z1 is independently “NZ14Z15”, wherein Z14 is hydrogen and Z15 is “—C (O) NH-alkyl”;
The group Z2 is independently hydrogen;
The group Z3 is independently “substituted alkyl”, wherein “substituted alkyl” is substituted by at least one substituent selected from the group consisting of the same or different, consisting of: ing:
(A) "aryl, heteroaryl, cycloalkyl, -N (alkyl) ₂ , -O-alkyl";
In this case, the said substituents of the substituent group (a) may optionally be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "halogen, F, Cl, Br, I";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (C)
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl”;
The group Z2 is independently hydrogen;
The group Z3 is, independently of one another, “phenyl-ethynyl, thiophen-3-yl-ethynyl, cyclopropyl-ethynyl, N-dimethyl-amino-prop-1-ynyl, 2-cyclohexyl-vinyl, 3-methoxy-propenyl, Selected from the group consisting of benzyl, 2- (4-fluoro-phenyl) -ethyl, 2- (4-fluoro-phenyl) -vinyl ”;
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (D)
The group Z1 is independently “NZ14Z15”, wherein Z14 is hydrogen and Z15 is “—C (O) NH-alkyl”;
The group Z2 is independently hydrogen;
The group Z3 is independently selected from the group consisting of:
(1) "-NZ10Z11";
In so doing, the radicals Z10, Z11, independently of one another, are selected from the group consisting of:
(A) "hydrogen, aryl";
However, when the substituent in the substituent group (a) is not hydrogen, it is further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, regardless of each other: :
(I) "cycloalkyl, heteroaryl, heterocyclylalkyl, -S (O) ₂ -alkyl, -NH-S (O) ₂ -alkyl, -C (O) NH-alkyl, -NH-C (O)- Alkyl, -C (O) O-alkyl ";
(B) "-C (O) -aryl";
In that case, depending on the case, at least one substituent selected from the group consisting of the following, which is the same or different, is independent of each other, and the substituents of the substituent group (a) and / or the substituent group (b) It may be further substituted by a group:
(I) "alkyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (D)
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl”;
The group Z2 is independently hydrogen;
The group Z3 is, independently of one another, “4-methyl-benzamide, 4-cyclohexyl-phenyl-amino, 4-methanesulfonyl-phenyl-amino, 3- (N-methanesulfonamido) -4-methyl-phenyl-amino, 3-N-methyl-benzamido-amino, 4-piperidin-1-ylmethyl-phenyl-amino, 4-thiophen-3-ylphenyl-amino, 4-N-acetamido-phenyl-amino, 3-benzoic acid-ethyl- Selected from the group consisting of "ester-amino";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (E)
The group Z1 is independently selected from the group consisting of:
(A) "NZ24Z25", wherein Z24 is hydrogen and Z25 is "-C (O) -C (O) -O-alkyl" or "-C (O) -C (O)-" NH-alkyl "or" -C (O) -NH-O-alkyl ";
In that case, the said substituents of the substituent group (a) may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "-OSi (alkyl) ₃ , -OC (O) -NH-alkyl, -OC (O) -O-alkyl, -P (O) (O-alkyl) ₂ , -P (O) (OH ) ₂ , -O-alkyl ";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Ii) "heterocyclyl, OH, -N (alkyl) ₂ , -OC (O) -alkyl";
In that case, depending on the case, the above substituents of the substituent group (ii) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Iii) "alkyl";
(B) "NZ26Z27", wherein Z26 is hydrogen and Z27 is "-C (O) -NH-alkyl";
However, said substituents of the substituent group (b) are further substituted by at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other:
(I) "-OSi (alkyl) ₃ , -OC (O) -NH-alkyl, -OC (O) -O-alkyl, -P (O) (O-alkyl) ₂ , -P (O) (OH ) ₂ , -O-alkyl ";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Ii) "heterocyclyl, OH, -N (alkyl) ₂ , -OC (O) -alkyl";
In that case, depending on the case, the above substituents of the substituent group (ii) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Iii) "alkyl";
The group Z2 is independently hydrogen;
The group Z3 is independently selected from the group consisting of:
(A) "Aryl";
In that case, the said substituents of the substituent group (a) may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "-O-alkyl, OH";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

In a preferred further embodiment, novel pyrido [2,3-b] pyrazine derivatives according to general formula (I) are provided, according to (E)
The group Z1 is independently of each other “3-methoxy-1-yl-urea, 3- (prop-1-in-3-yl) -1-yl-urea, 3- [4- (t-butyl-dimethyl). -Silanyloxy) -butyl] -1-yl-urea, 4- (carbamic acid-N-ethyl-ester) -butyl-1-yl-urea, 4- (carbonic acid-methyl-ester) -butyl-1-yl- Urea, 4- (carbonic acid-2,3-dihydroxy-propyl-ester) -butyl-1-yl-urea, 4- (carbonic acid-2,2-dimethyl- [1,3] dioxolan-4-ylmethyl-ester) -Butyl-1-yl-urea, 4- (phosphate-diethyl-ester) -butyl-1-yl-urea, 4-phosphate-butyl-1-yl-urea, N-oxalic acid-monoamido-ethyl- Ester, N-ethyl-N'-oxalic acid-a , 2- (phosphate-diethyl-ester) -ethyl-1-yl-urea, 2-phosphate-ethyl-1-yl-urea, 3- (2-diethylamino-ethoxy) -propyl-1-yl- Urea, 4- [2,2-dimethyl-propanoic acid- (2,2-dimethyl-propionyloxy-methoxy) -phosphinoyloxymethyl-ester] -butyl-1-yl-urea, 4- [acetic acid-1 -(1-acetoxy-ethoxy) -ethoxy-phosphinoyloxy] -butyl-1-yl-urea ";
The group Z2 is independently hydrogen;
The group Z3 is independently selected from the group consisting of "phenyl, 4-hydroxy-3-methoxy-phenyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen.

［式中、置換基Ｒ１〜Ｒ４は、以下の意味を有する：
Ｒ１及びＲ２は、互いに無関係に、水素もしくはＮＲ５Ｒ６を意味するが、但し、Ｒ１がＮＲ５Ｒ６の場合には、Ｒ２はＨであり、かつＲ２がＮＲ５Ｒ６である場合には、Ｒ１はＨであり、
その際、Ｒ５は、水素、アルキル、Ｒ３８、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、前記のアルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基及びヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で再び、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、Ｎ（アルキル）₂、ＮＯ₂、ＳＨ、Ｓ−アルキル、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−アリール、ＯＳＯ₃Ｈ、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、ＣＨＯ、Ｃ（Ｏ）ＯＨ、Ｃ（Ｏ）ＯＲ１２、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ１２、Ｃ（Ｏ）ＮＲ１２Ｒ１３、ＳＯ₃Ｈ、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ１２及びＲ１３は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ１２及びＲ１３は、一緒になって、ヘテロシクリル環を形成することができる；
及び
Ｒ６は、−Ｃ（Ｙ）ＮＲ７Ｒ８を意味してよく、その際、Ｙは、互いに無関係に、ＯもしくはＳであってよく、かつＲ７及びＲ８は、互いに無関係に、以下の意味を有してよい：
水素、
非置換もしくは置換されたアルキル、
その際、前記アルキル基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、Ｎ（アルキル）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−シクロアルキル、Ｓ−ヘテロシクリル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ−アルキル、ＳＯ−アリール、ＳＯ₂−アルキル、ＳＯ₂−アリール、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができる；
非置換もしくは置換されたシクロアルキル、
その際、前記シクロアルキル基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、Ｎ（アルキル）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＯＨ、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、アルキルもしくはアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができる；
非置換もしくは置換されたヘテロシクリル、
その際、前記ヘテロシクリル基は、ＯＨ、Ｏ−アルキル、Ｏ−アリール、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、アルキル、アルキル−アリールもしくはアリールで、同一もしくは異なって、一置換もしくは多置換されていてよい；
非置換もしくは置換されたアリール、
その際、前記アリール基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−Ｒ３８、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、ＮＨ−アルキル−ＮＨ₂、ＮＨ−アルキル−ＯＨ、Ｎ（アルキル）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨ（Ｏ）−Ｒ３８、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−シクロアルキル、Ｓ−ヘテロシクリル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−Ｒ３８、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、Ｏ−アルキル−ＯＨ、Ｏ（ＣＨ₂）_n−Ｏ、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−Ｒ３８、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ−アルキル、ＳＯ−アリール、ＳＯ₂−アルキル、ＳＯ₂−アリール、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつｎは、１、２もしくは３の値をとることができる；
非置換もしくは置換されたヘテロアリール、
その際、前記ヘテロアリール基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−Ｒ３８、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、ＮＨ−アルキル−ＮＨ₂、ＮＨ−アルキル−ＯＨ、Ｎ（アルキル）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨ（Ｏ）−Ｒ３８、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−Ｒ３８、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−Ｒ３８、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができる；
−Ｃ（Ｏ）−Ｒ３９、
その際、Ｒ３９は、アルキル、アリールもしくはヘテロアリールであってよく、かつ前記アルキル置換基、アリール置換基及びヘテロアリール置換基は、その側で再び置換されていてよい；
又は
Ｒ７及びＲ８は、一緒になって、ヘテロシクリル環を形成することができる、
Ｒ３及びＲ４は、互いに無関係に、以下の意味を有してよい：
水素、
その際、Ｒ３及びＲ４は、同時に水素ではない、
置換されたアルキル、
その際、前記のアルキル基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、Ｎ（アルキル）₂、ＳＨ、Ｓ−アルキル、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−アリール、ＯＳＯ₃Ｈ、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）ＯＨ、Ｃ（Ｏ）ＯＲ１４、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ１４、Ｃ（Ｏ）ＮＲ１４Ｒ１５、ＳＯ₃Ｈ、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ１４及びＲ１５は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ１４及びＲ１５は、一緒になって、ヘテロシクリル環を形成することができる；
置換されたアリール、
その際、前記アリール基は、同一もしくは異なって、ＮＨ−アルキル、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、Ｎ（アルキル）₂、Ｎ（アリール）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、Ｓ−アルキル、Ｓ−アリール、Ｓ−ヘテロアリール、Ｏ−アルキル、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂−アルキル、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ−アルキル、ＳＯ−アリール、ＳＯ₂−アルキル、ＳＯ₂−アリール、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールの群から選択される置換基で一置換もしくは多置換されていてよく、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基及びアルキル−ヘテロアリール置換基は、その側で再び、Ｏ（−アルキル−Ｏ）_p−アルキル、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）ＯＲ１６、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ１６、Ｃ（Ｏ）ＮＨＲ１６Ｒ１７、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールもしくはアルキルアリールで置換されており、その際、ｐは、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ１６及びＲ１７は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ１６及びＲ１７は、一緒になって、ヘテロシクリル環を形成することができる；
但し、Ｒ３もしくはＲ４が、アルキル−ヘテロシクリル置換されたアリールを意味する場合には、相応してＲ４もしくはＲ３≠アリールである；
その際、前記アリール基は、同一もしくは異なって、ＮＲ２０−アルキル、ＮＨ−Ｒ３８、ＮＨＣ（Ｏ）−Ｒ３８、ＮＲ１９Ｃ（Ｏ）−アルキル、ＮＲ１９Ｃ（Ｏ）−シクロアルキル、ＮＲ１９Ｃ（Ｏ）−ヘテロシクリル、ＮＲ１９Ｃ（Ｏ）−アリール、ＮＲ１９Ｃ（Ｏ）−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）−アルキル−シクロアルキル、ＮＲ１８Ｃ（Ｏ）−アルキル−ヘテロシクリル、ＮＲ１９Ｃ（Ｏ）−アルキル−アリール、ＮＲ１９Ｃ（Ｏ）−アルキル−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）Ｏ−Ｒ１９、ＮＲ１８Ｃ（Ｏ）ＮＲ１８Ｒ１８、Ｏ−Ｒ３８、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−アルキル−シクロアルキル、ＯＣ（Ｏ）−アルキル−ヘテロシクリル、ＯＣ（Ｏ）Ｏ−Ｒ１９、ＯＣ（Ｏ）ＮＲ１８Ｒ１８、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）Ｏ−Ｒ３８、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＲ２０−アルキル、Ｃ（Ｏ）ＮＲ１９−アルキル−Ｒ２１、Ｃ（Ｏ）ＮＲ１８Ｏ−Ｒ１８、Ｃ（Ｏ）ＮＲ１８ＮＲ１８Ｒ１８の群から選択される置換基で一置換もしくは多置換されていてよく、かつ前記のアルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基及びアルキル−ヘテロアリール置換基は、その側で再び、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、Ｎ（アルキル）₂、ＮＯ₂、ＳＨ、Ｓ−アルキル、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−アリール、ＯＳＯ₃Ｈ、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、ＣＨＯ、Ｃ（Ｏ）ＯＨ、Ｃ（Ｏ）ＯＲ２２、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ２２、Ｃ（Ｏ）ＮＲ２２Ｒ２３、ＳＯ₃Ｈ、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールもしくはアルキルアリールで置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ２２及びＲ２３は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ２２及びＲ２３は、一緒になって、ヘテロシクリル環を形成することができる；
置換されたヘテロアリール、
その際、前記ヘテロアリール基は、同一もしくは異なって、ＮＨ−アルキル、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、Ｎ（アルキル）₂、Ｎ（アリール）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、Ｓ−アルキル、Ｓ−アリール、Ｓ−ヘテロアリール、Ｏ−アルキル、Ｏ−シクロアルキル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂−アルキル、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールの群から選択される置換基で一置換もしくは多置換されていてよく、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基及びアルキル−ヘテロアリール置換基は、その側で再び、Ｏ（−アルキル−Ｏ）_p−アルキル、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）ＯＲ１６、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ１６、Ｃ（Ｏ）ＮＨＲ１６Ｒ１７、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールもしくはアルキルアリールで置換されており、その際、ｐは、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ１６及びＲ１７は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ１６及びＲ１７は、一緒になって、ヘテロシクリル環を形成することができる；
その際、前記ヘテロアリール基は、同一もしくは異なって、ＮＲ２０−アルキル、ＮＨ−Ｒ３８、ＮＨＣ（Ｏ）−Ｒ３８、ＮＲ１９Ｃ（Ｏ）−アルキル、ＮＲ１９Ｃ（Ｏ）−シクロアルキル、ＮＲ１９Ｃ（Ｏ）−ヘテロシクリル、ＮＲ１９Ｃ（Ｏ）−アリール、ＮＲ１９Ｃ（Ｏ）−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）−アルキル−シクロアルキル、ＮＲ１８Ｃ（Ｏ）−アルキル−ヘテロシクリル、ＮＲ１９Ｃ（Ｏ）−アルキル−アリール、ＮＲ１９Ｃ（Ｏ）−アルキル−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）Ｏ−Ｒ１９、ＮＲ１８Ｃ（Ｏ）ＮＲ１８Ｒ１８、ＮＨＳＯ₂−アルキル−ヘテロシクリル、Ｏ−Ｒ３８、Ｏ−ヘテロシクリル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−アルキル−シクロアルキル、ＯＣ（Ｏ）−アルキル−ヘテロシクリル、ＯＣ（Ｏ）Ｏ−Ｒ１９、ＯＣ（Ｏ）ＮＲ１８Ｒ１８、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）Ｏ−Ｒ３８、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＲ２０−アルキル、Ｃ（Ｏ）ＮＲ１９−アルキル−Ｒ２１、Ｃ（Ｏ）ＮＲ１８Ｏ−Ｒ１８、Ｃ（Ｏ）ＮＲ１８ＮＲ１８Ｒ１８の群から選択される置換基で一置換もしくは多置換されていてよく、かつ前記のアルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基及びアルキル−ヘテロアリール置換基は、その側で再び、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、Ｎ（アルキル）₂、ＮＯ₂、ＳＨ、Ｓ−アルキル、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−アリール、ＯＳＯ₃Ｈ、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、ＣＨＯ、Ｃ（Ｏ）ＯＨ、Ｃ（Ｏ）ＯＲ２２、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ２２、Ｃ（Ｏ）ＮＲ２２Ｒ２３、ＳＯ₃Ｈ、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールもしくはアルキルアリールで置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ２２及びＲ２３は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ２２及びＲ２３は、一緒になって、ヘテロシクリル環を形成することができる；
ＮＲ２４Ｒ２５、
その際、Ｒ２４は、−Ｃ（Ｏ）−Ｒ２６、−ＳＯ₂Ｒ２６、−Ｃ（Ｏ）ＯＲ２６もしくは−Ｃ（Ｏ）−ＮＲ２７Ｒ２８であってよく、かつＲ２５は、水素、アルキル、シクロアルキル、アリールもしくはヘテロアリールであってよく、かつＲ２６は、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリールであってよく、かつＲ２７及びＲ２８は、互いに無関係に、水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリールであってよく、又はＲ２７及びＲ２８は、一緒になって、ヘテロシクリル環を形成することができ、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基及びヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で再び置換されていてよい；
Ｒ１８は、水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよい、
Ｒ１９は、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよい、
Ｒ２０は、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよい、
Ｒ２１は、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールであってよい、
Ｒ３８は、アルキルであってよく、その際、前記アルキル基は、飽和もしくは不飽和、直鎖状もしくは分枝鎖状であってよく、９〜３０個の炭素原子を有する、すなわちＣ₉〜Ｃ₃₀−アルカニル、Ｃ₉〜Ｃ₃₀−アルケニル及びＣ₉〜Ｃ₃₀−アルキニルである。その際、アルケニルは、少なくとも１個のＣ−Ｃ二重結合を有し、かつアルキニルは、少なくとも１個のＣ−Ｃ三重結合を有し、その際、アルケニルは、（Ｅ）立体配置か（Ｚ）立体配置のいずれかで存在することができる。前記アルキル基が、ノニル、デシル、ドデシル、ヘキサデシル、オクタデシル、エイコシル、ヘニコシル、ドコシル、テトラコシル、ノナコシル、オクタデセニル、ドコセニル、テトラコセニル及びオクタデシニルを有する基から選択されることが好ましい］で示される一連のピリド［２，３−ｂ］ピラジンからの新規化合物を記載する。 A further aspect of the present application is a compound of the general formula (II)

[Wherein the substituents R1 to R4 have the following meanings:
R1 and R2, independently of one another, denote hydrogen or NR5R6, provided that when R1 is NR5R6, R2 is H and when R2 is NR5R6, R1 is H;
Wherein R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, the alkyl substituent as defined above, A cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent or alkyl-heteroaryl substituent is again on that side, F, Cl, Br, I, CN, CF _Three , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-aryl, OSO _Three H, OP (O) (OH) ₂ , OP (O) (O alkyl) ₂ , OP (O) (Oaryl) ₂ , CHO, C (O) OH, C (O) OR12, C (O) NH ₂ , C (O) NHR12, C (O) NR12R13, SO _Three H, SO ₂ Alkyl, SO ₂ Aryl, P (O) (OH) ₂ , P (O) (O alkyl) ₂ , P (O) (Oaryl) ₂ , Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, which may be the same or different and mono- or poly-substituted, and p can have a value of 0, 1, 2, 3, 4 or 5. And the groups R12 and R13, independently of one another, can be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, or R12 and R13 Together can form a heterocyclyl ring;
as well as
R6 may mean -C (Y) NR7R8, where Y may be O or S independently of one another, and R7 and R8 independently of one another have the following meanings: Good:
hydrogen,
Unsubstituted or substituted alkyl,
In this case, the alkyl group may be F, Cl, Br, I, CF. _Three , CN, NH ₂ , NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (Alkyl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O ) -Alkyl-heteroaryl, NHSO ₂ -Alkyl, NHSO ₂ -Cycloalkyl, NHSO ₂ -Heterocyclyl, NHSO ₂ -Aryl, NHSO ₂ -Heteroaryl, NHSO ₂ -Alkyl-aryl, NHSO ₂ -Alkyl-heteroaryl, NO ₂ , SH, S-alkyl, S-cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O ) -Alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl- Heteroaryl, OSO _Three H, OSO ₂ -Alkyl, OSO ₂ -Cycloalkyl, OSO ₂ -Heterocyclyl, OSO ₂ -Aryl, OSO ₂ -Heteroaryl, OSO ₂ -Alkyl-aryl, OSO ₂ -Alkyl-heteroaryl, OP (O) (OH) ₂ , C (O) -alkyl, C (O) -aryl, C (O) -heteroaryl, CO ₂ H, CO ₂ -Alkyl, CO ₂ -Cycloalkyl, CO ₂ -Heterocyclyl, CO ₂ -Aryl, CO ₂ -Heteroaryl, CO ₂ -Alkyl-cycloalkyl, CO ₂ -Alkyl-heterocyclyl, CO ₂ -Alkyl-aryl, CO ₂ -Alkyl-heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl -Cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO-alkyl, SO-aryl, SO ₂ -Alkyl, SO ₂ -Aryl, SO ₂ NH ₂ , SO ₂ NH-alkyl, SO ₂ NH-aryl, SO ₂ NH-heteroaryl, SO ₂ NH-alkyl-aryl, SO _Three H, SO ₂ O-alkyl, SO ₂ O-aryl, SO ₂ O-alkyl-aryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted, where p is 0, 1, 2, 3, 4 or 5 Can take values;
Unsubstituted or substituted cycloalkyl,
In this case, the cycloalkyl group is F, Cl, Br, I, NH. ₂ , NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O ) -Alkyl-heteroaryl, NHSO ₂ -Alkyl, NHSO ₂ -Cycloalkyl, NHSO ₂ -Heterocyclyl, NHSO ₂ -Aryl, NHSO ₂ -Heteroaryl, NHSO ₂ -Alkyl-aryl, NHSO ₂ -Alkyl-heteroaryl, OH, O (-alkyl-O) _p -Alkyl, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, OSO _Three H, OSO ₂ -Alkyl, OSO ₂ -Cycloalkyl, OSO ₂ -Heterocyclyl, OSO ₂ -Aryl, OSO ₂ -Heteroaryl, OSO ₂ -Alkyl-aryl, OSO ₂ -Alkyl-heteroaryl, OP (O) (OH) ₂ , CO ₂ H, CO ₂ -Alkyl, CO ₂ -Cycloalkyl, CO ₂ -Heterocyclyl, CO ₂ -Aryl, CO ₂ -Heteroaryl, CO ₂ -Alkyl-cycloalkyl, CO ₂ -Alkyl-heterocyclyl, CO ₂ -Alkyl-aryl, CO ₂ -Alkyl-heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl -Cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , Alkyl or aryl, which may be the same or different and mono- or poly-substituted, where p can have a value of 0, 1, 2, 3, 4 or 5;
Unsubstituted or substituted heterocyclyl,
In this case, the heterocyclyl group includes OH, O-alkyl, O-aryl, NH ₂ , NH-alkyl, NH-aryl, alkyl, alkyl-aryl or aryl, which may be the same or different and mono- or polysubstituted;
Unsubstituted or substituted aryl,
In this case, the aryl group may be F, Cl, Br, I, CF. _Three , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl- Heteroaryl, NH-alkyl-NH ₂ , NH-alkyl-OH, N (alkyl) ₂ , NHC (O) -alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O)- Alkyl-aryl, NHC (O) -alkyl-heteroaryl, NHSO ₂ -Alkyl, NHSO ₂ -Cycloalkyl, NHSO ₂ -Heterocyclyl, NHSO ₂ -Aryl, NHSO ₂ -Heteroaryl, NHSO ₂ -Alkyl-aryl, NHSO ₂ -Alkyl-heteroaryl, NO ₂ , SH, S-alkyl, S-cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-R38, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl , O-alkyl-OH, O (CH ₂ ) _n -O, OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O ) -Alkyl-aryl, OC (O) -alkyl-heteroaryl, OSO _Three H, OSO ₂ -Alkyl, OSO ₂ -Cycloalkyl, OSO ₂ -Heterocyclyl, OSO ₂ -Aryl, OSO ₂ -Heteroaryl, OSO ₂ -Alkyl-aryl, OSO ₂ -Alkyl-heteroaryl, OP (O) (OH) ₂ , C (O) -alkyl, C (O) -aryl, C (O) -heteroaryl, CO ₂ H, CO ₂ -Alkyl, CO ₂ -R38, CO ₂ -Cycloalkyl, CO ₂ -Heterocyclyl, CO ₂ -Aryl, CO ₂ -Heteroaryl, CO ₂ -Alkyl-cycloalkyl, CO ₂ -Alkyl-heterocyclyl, CO ₂ -Alkyl-aryl, CO ₂ -Alkyl-heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl , C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl ) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO-alkyl, SO-aryl, SO ₂ -Alkyl, SO ₂ -Aryl, SO ₂ NH ₂ , SO ₂ NH-alkyl, SO ₂ NH-aryl, SO ₂ NH-heteroaryl, SO ₂ NH-alkyl-aryl, SO _Three H, SO ₂ O-alkyl, SO ₂ O-aryl, SO ₂ O-alkyl-aryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different and mono- or polysubstituted, where p is 0, 1, 2, 3, 4 or Can have a value of 5 and n can have a value of 1, 2 or 3;
Unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group includes F, Cl, Br, I, and CF. _Three , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl- Heteroaryl, NH-alkyl-NH ₂ , NH-alkyl-OH, N (alkyl) ₂ , NHC (O) -alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O)- Alkyl-aryl, NHC (O) -alkyl-heteroaryl, NHSO ₂ -Alkyl, NHSO ₂ -Cycloalkyl, NHSO ₂ -Heterocyclyl, NHSO ₂ -Aryl, NHSO ₂ -Heteroaryl, NHSO ₂ -Alkyl-aryl, NHSO ₂ -Alkyl-heteroaryl, NO ₂ , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-R38, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl , OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O)- Alkyl-aryl, OC (O) -alkyl-heteroaryl, OSO _Three H, OSO ₂ -Alkyl, OSO ₂ -Cycloalkyl, OSO ₂ -Heterocyclyl, OSO ₂ -Aryl, OSO ₂ -Heteroaryl, OSO ₂ -Alkyl-aryl, OSO ₂ -Alkyl-heteroaryl, OP (O) (OH) ₂ , C (O) -alkyl, C (O) -aryl, C (O) -heteroaryl, CO ₂ H, CO ₂ -Alkyl, CO ₂ -R38, CO ₂ -Cycloalkyl, CO ₂ -Heterocyclyl, CO ₂ -Aryl, CO ₂ -Heteroaryl, CO ₂ -Alkyl-cycloalkyl, CO ₂ -Alkyl-heterocyclyl, CO ₂ -Alkyl-aryl, CO ₂ -Alkyl-heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl , C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl ) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO ₂ NH ₂ , SO ₂ NH-alkyl, SO ₂ NH-aryl, SO ₂ NH-heteroaryl, SO ₂ NH-alkyl-aryl, SO _Three H, SO ₂ O-alkyl, SO ₂ O-aryl, SO ₂ O-alkyl-aryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted, where p is 0, 1, 2, 3, 4 or Can take the value of 5;
-C (O) -R39,
Wherein R39 may be alkyl, aryl or heteroaryl, and said alkyl, aryl and heteroaryl substituents may be substituted again on that side;
Or
R7 and R8 can be taken together to form a heterocyclyl ring,
R3 and R4 may have the following meanings independently of each other:
hydrogen,
Where R3 and R4 are not simultaneously hydrogen,
Substituted alkyl,
In this case, the alkyl group includes F, Cl, Br, I, CN, CF. _Three , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , SH, S-alkyl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-aryl, OSO _Three H, OP (O) (OH) ₂ , OP (O) (O alkyl) ₂ , OP (O) (Oaryl) ₂ , C (O) OH, C (O) OR14, C (O) NH ₂ , C (O) NHR14, C (O) NR14R15, SO _Three H, SO ₂ Alkyl, SO ₂ Aryl, P (O) (OH) ₂ , P (O) (O alkyl) ₂ , P (O) (Oaryl) ₂ , Cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different and mono- or poly-substituted, where p may have a value of 0, 1, 2, 3, 4 or 5. And the groups R14 and R15 can be, independently of one another, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, or R14 and R15 together can form a heterocyclyl ring;
Substituted aryl,
In this case, the aryl groups are the same or different and are NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH- Alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O ) -Alkyl-heteroaryl, NHSO ₂ -Alkyl, NHSO ₂ -Cycloalkyl, NHSO ₂ -Heterocyclyl, NHSO ₂ -Aryl, NHSO ₂ -Heteroaryl, NHSO ₂ -Alkyl-aryl, NHSO ₂ -Alkyl-heteroaryl, S-alkyl, S-aryl, S-heteroaryl, O-alkyl, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O- Alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -Heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, OSO ₂ -Alkyl, OSO ₂ -Cycloalkyl, OSO ₂ -Heterocyclyl, OSO ₂ -Aryl, OSO ₂ -Heteroaryl, OSO ₂ -Alkyl-aryl, OSO ₂ -Alkyl-heteroaryl, C (O) -alkyl, C (O) -aryl, C (O) -heteroaryl, CO ₂ -Alkyl, CO ₂ -Cycloalkyl, CO ₂ -Heterocyclyl, CO ₂ -Aryl, CO ₂ -Heteroaryl, CO ₂ -Alkyl-cycloalkyl, CO ₂ -Alkyl-heterocyclyl, CO ₂ -Alkyl-aryl, CO ₂ -Alkyl-heteroaryl, C (O) NH-alkyl, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C ( O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO-alkyl, SO-aryl, SO ₂ -Alkyl, SO ₂ -Aryl, SO ₂ NH-alkyl, SO ₂ NH-aryl, SO ₂ NH-heteroaryl, SO ₂ NH-alkyl-aryl, SO ₂ O-alkyl, SO ₂ O-aryl, SO ₂ O-alkyl-aryl, alkyl, cycloalkyl, heterocyclyl, aryl, may be mono- or poly-substituted with a substituent selected from the group consisting of alkyl, cycloalkyl, and heterocyclyl , Aryl substituents, heteroaryl substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents are again O (-alkyl-O) on that side. _p -Alkyl, OP (O) (Oalkyl) ₂ , OP (O) (Oaryl) ₂ , C (O) OR16, C (O) NH ₂ , C (O) NHR16, C (O) NHR16R17, SO ₂ Alkyl, SO ₂ Aryl, P (O) (OH) ₂ , P (O) (O alkyl) ₂ , P (O) (Oaryl) ₂ , Cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p can have a value of 1, 2, 3, 4 or 5 and the groups R16 and R17 can be Irrespective of alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, or R16 and R17 taken together are heterocyclyl ring Can be formed;
Provided that when R3 or R4 means alkyl-heterocyclyl substituted aryl, then R4 or R3 ≠ aryl;
In this case, the aryl groups are the same or different, and are NR20-alkyl, NH-R38, NHC (O) -R38, NR19C (O) -alkyl, NR19C (O) -cycloalkyl, NR19C (O) -heterocyclyl, NR19C (O) -aryl, NR19C (O) -heteroaryl, NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NR19C (O) -alkyl-aryl, NR19C (O) -alkyl- Heteroaryl, NR18C (O) O-R19, NR18C (O) NR18R18, O-R38, OC (O) -R38, OC (O) -alkyl-cycloalkyl, OC (O) -alkyl-heterocyclyl, OC (O ) O-R19, OC (O) NR18R18, OP (O) (O al Le) ₂ , OP (O) (Oaryl) ₂ , C (O) O-R38, C (O) NH-R38, C (O) NR20-alkyl, C (O) NR19-alkyl-R21, C (O) NR18O-R18, C (O) NR18NR18R18 And may be mono- or poly-substituted with a substituent selected from the above-mentioned alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl -Heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents again on that side, F, Cl, Br, I, CN, CF _Three , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-aryl, OSO _Three H, OP (O) (OH) ₂ , OP (O) (O alkyl) ₂ , OP (O) (Oaryl) ₂ , CHO, C (O) OH, C (O) OR22, C (O) NH ₂ , C (O) NHR22, C (O) NR22R23, SO _Three H, SO ₂ Alkyl, SO ₂ Aryl, P (O) (OH) ₂ , P (O) (O alkyl) ₂ , P (O) (Oaryl) ₂ , Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p can have a value of 0, 1, 2, 3, 4 or 5 and the group R22 And R23, independently of one another, may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, or R22 and R23 together Can form a heterocyclyl ring;
Substituted heteroaryl,
In this case, the heteroaryl groups may be the same or different, and may be NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH -Alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O ) -Alkyl-heteroaryl, NHSO ₂ -Alkyl, NHSO ₂ -Cycloalkyl, NHSO ₂ -Heterocyclyl, NHSO ₂ -Aryl, NHSO ₂ -Heteroaryl, NHSO ₂ -Alkyl-aryl, NHSO ₂ -Alkyl-heteroaryl, S-alkyl, S-aryl, S-heteroaryl, O-alkyl, O-cycloalkyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, OSO ₂ -Alkyl, OSO ₂ -Cycloalkyl, OSO ₂ -Heterocyclyl, OSO ₂ -Aryl, OSO ₂ -Heteroaryl, OSO ₂ -Alkyl-aryl, OSO ₂ -Alkyl-heteroaryl, C (O) -alkyl, C (O) -aryl, C (O) -heteroaryl, CO ₂ -Alkyl, CO ₂ -Cycloalkyl, CO ₂ -Heterocyclyl, CO ₂ -Aryl, CO ₂ -Heteroaryl, CO ₂ -Alkyl-cycloalkyl, CO ₂ -Alkyl-heterocyclyl, CO ₂ -Alkyl-aryl, CO ₂ -Alkyl-heteroaryl, C (O) NH-alkyl, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C ( O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO ₂ NH-alkyl, SO ₂ NH-aryl, SO ₂ NH-heteroaryl, SO ₂ NH-alkyl-aryl, SO ₂ O-alkyl, SO ₂ O-aryl, SO ₂ O-alkyl-aryl, alkyl, cycloalkyl, heterocyclyl, aryl, may be mono- or poly-substituted with a substituent selected from the group consisting of alkyl, cycloalkyl, and heterocyclyl , Aryl substituents, heteroaryl substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents are again O (-alkyl-O) on that side. _p -Alkyl, OP (O) (Oalkyl) ₂ , OP (O) (Oaryl) ₂ , C (O) OR16, C (O) NH ₂ , C (O) NHR16, C (O) NHR16R17, SO ₂ Alkyl, SO ₂ Aryl, P (O) (OH) ₂ , P (O) (O alkyl) ₂ , P (O) (Oaryl) ₂ , Cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p can have a value of 1, 2, 3, 4 or 5 and the groups R16 and R17 can be Irrespective of alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, or R16 and R17 taken together are heterocyclyl ring Can be formed;
In this case, the heteroaryl groups may be the same or different, and NR20-alkyl, NH-R38, NHC (O) -R38, NR19C (O) -alkyl, NR19C (O) -cycloalkyl, NR19C (O) -heterocyclyl. NR19C (O) -aryl, NR19C (O) -heteroaryl, NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NR19C (O) -alkyl-aryl, NR19C (O) -alkyl -Heteroaryl, NR18C (O) O-R19, NR18C (O) NR18R18, NHSO ₂ -Alkyl-heterocyclyl, O-R38, O-heterocyclyl, OC (O) -R38, OC (O) -alkyl-cycloalkyl, OC (O) -alkyl-heterocyclyl, OC (O) O-R19, OC (O ) NR18R18, OP (O) (Oalkyl) ₂ , OP (O) (Oaryl) ₂ , C (O) O-R38, C (O) NH-R38, C (O) NR20-alkyl, C (O) NR19-alkyl-R21, C (O) NR18O-R18, C (O) NR18NR18R18 And may be mono- or poly-substituted with a substituent selected from the above-mentioned alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl -Heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents again on that side, F, Cl, Br, I, CN, CF _Three , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF _Three , O (-alkyl-O) _p -Alkyl, O-aryl, OSO _Three H, OP (O) (OH) ₂ , OP (O) (O alkyl) ₂ , OP (O) (Oaryl) ₂ , CHO, C (O) OH, C (O) OR22, C (O) NH ₂ , C (O) NHR22, C (O) NR22R23, SO _Three H, SO ₂ Alkyl, SO ₂ Aryl, P (O) (OH) ₂ , P (O) (O alkyl) ₂ , P (O) (Oaryl) ₂ , Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p can have a value of 0, 1, 2, 3, 4 or 5 and the group R22 And R23, independently of one another, may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, or R22 and R23 together Can form a heterocyclyl ring;
NR24R25,
In that case, R24 is -C (O) -R26, -SO. ₂ R26, -C (O) OR26 or -C (O) -NR27R28, and R25 may be hydrogen, alkyl, cycloalkyl, aryl or heteroaryl, and R26 is alkyl, cycloalkyl, May be heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, and R27 and R28, independently of one another, are hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, May be heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, or R27 and R28 may be taken together to form a heterocyclyl ring and A kill substituent, a cycloalkyl substituent, a heterocyclyl substituent, an aryl substituent and a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent; May be substituted again on the side;
R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl.
R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl,
R38 may be alkyl, wherein the alkyl group may be saturated or unsaturated, linear or branched and has 9 to 30 carbon atoms, ie C ₉ ~ C ₃₀ -Alkanyl, C ₉ ~ C ₃₀ -Alkenyl and C ₉ ~ C ₃₀ -Alkynyl. In this case, the alkenyl has at least one C—C double bond and the alkynyl has at least one C—C triple bond, wherein the alkenyl has the (E) configuration ( Z) can exist in any of the configurations. The alkyl group is preferably selected from the group having nonyl, decyl, dodecyl, hexadecyl, octadecyl, eicosyl, henicosyl, docosyl, tetracosyl, nonacosyl, octadecenyl, dococenyl, tetracocenyl and octadecynyl]. New compounds from 2,3-b] pyrazine are described.

［式中、置換基Ｒ１〜Ｒ４は、以下の意味を有する：
Ｒ１及びＲ２は、互いに無関係に、水素もしくはＮＲ５Ｒ６を意味するが、但し、Ｒ１がＮＲ５Ｒ６の場合には、Ｒ２はＨであり、かつＲ２がＮＲ５Ｒ６である場合には、Ｒ１はＨであり、
その際、Ｒ５は、水素、アルキル、Ｒ３８、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、前記のアルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基及びヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で再び、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、Ｎ（アルキル）₂、ＮＯ₂、ＳＨ、Ｓ−アルキル、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−アリール、ＯＳＯ₃Ｈ、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、ＣＨＯ、Ｃ（Ｏ）ＯＨ、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＯＲ１２、Ｃ（Ｏ）ＮＨＲ１２、Ｃ（Ｏ）ＮＲ１２Ｒ１３、ＳＯ₃Ｈ、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ１２及びＲ１３は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ１２及びＲ１３は、一緒になって、ヘテロシクリル環を形成することができる；
Ｒ６は、−Ｃ（Ｏ）ＮＲ９−Ｙ−Ｒ１０を意味してよく、その際、Ｙは、互いに無関係に、ＯもしくはＮＲ１１であってよい；
Ｒ９は、水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリールであってよく、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基及びヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で置換されていてよい；
Ｒ１０及びＲ１１は、互いに無関係に、以下の意味を有することができる：
水素、
非置換もしくは置換されたアルキル、
非置換もしくは置換されたシクロアルキル、
非置換もしくは置換されたヘテロシクリル、
その際、前記ヘテロシクリル基は、ＯＨ、Ｏ−アルキル、Ｏ−アリール、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、アルキル、アルキル−アリールもしくはアリールで、同一もしくは異なって、一置換もしくは多置換されていてよい；
非置換もしくは置換されたアリール、
その際、前記アリール基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−Ｒ３８、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、ＮＨ−アルキル−ＮＨ₂、ＮＨ−アルキル−ＯＨ、Ｎ（アルキル）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨ（Ｏ）−Ｒ３８、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−シクロアルキル、Ｓ−ヘテロシクリル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−Ｒ３８、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、Ｏ−アルキル−ＯＨ、Ｏ（ＣＨ₂）_n−Ｏ、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−Ｒ３８、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ−アルキル、ＳＯ−アリール、ＳＯ₂−アルキル、ＳＯ₂−アリール、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができる；
非置換もしくは置換されたヘテロアリール、
その際、前記ヘテロアリール基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−Ｒ３８、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、ＮＨ−アルキル−ＮＨ₂、ＮＨ−アルキル−ＯＨ、Ｎ（アルキル）₂、ＮＨＣ（Ｏ）−アルキル、ＮＨ（Ｏ）−Ｒ３８、ＮＨＣ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−Ｒ３８、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−Ｒ３８、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができる；
又は、Ｒ１０及びＲ１１は、一緒になって、ヘテロシクリル環を形成することができ、
Ｒ３及びＲ４は、互いに無関係に、以下の意味を有することができる：
水素、
ヒドロキシル、
ハロゲン、例えばフッ素、塩素、臭素、ヨウ素、
非置換もしくは置換されたアルキル、
その際、前記のアルキル基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＮ、ＣＦ₃、ＮＨ₂、ＮＨ−アルキル、ＮＨ−アリール、Ｎ（アルキル）₂、ＳＨ、Ｓ−アルキル、ＯＨ、ＯＣＦ₃、Ｏ（−アルキル−Ｏ）_p−アルキル、Ｏ−アリール、ＯＳＯ₃Ｈ、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）ＯＨ、Ｃ（Ｏ）ＯＲ１４、Ｃ（Ｏ）ＮＨ₂、Ｃ（Ｏ）ＮＨＲ１４、Ｃ（Ｏ）ＮＲ１４Ｒ１５、ＳＯ₃Ｈ、ＳＯ₂アルキル、ＳＯ₂アリール、Ｐ（Ｏ）（ＯＨ）₂、Ｐ（Ｏ）（Ｏアルキル）₂、Ｐ（Ｏ）（Ｏアリール）₂、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、その際、ｐは、０、１、２、３、４もしくは５の値をとることができ、かつ基Ｒ１４及びＲ１５は、互いに無関係に、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、又はＲ１４及びＲ１５は、一緒になって、ヘテロシクリル環を形成することができる；
非置換もしくは置換されたアリール、
その際、前記アリール基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−Ｒ３８、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、Ｎ（アルキル）₂、Ｎ（アリール）₂、ＮＲ２０−アルキル、ＮＨＣ（Ｏ）−アルキル、ＮＨＣ（Ｏ）−Ｒ３８、ＮＲ１９（Ｏ）−アルキル、ＮＨＣ（Ｏ）−シクロアルキル、ＮＲ１９Ｃ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＲ１９Ｃ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＲ１９Ｃ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＲ１９Ｃ（Ｏ）−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）−アルキル−シクロアルキル、ＮＲ１８Ｃ（Ｏ）−アルキル−ヘテロシクリル、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＲ１９Ｃ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＲ１９Ｃ（Ｏ）−アルキル−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）Ｏ−Ｒ１９、ＮＲ１８Ｃ（Ｏ）ＮＲ１８Ｒ１８、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−ヘテロシクリル、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ−アルキル、Ｏ−Ｒ３８、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、Ｏ−（ＣＨ₂）_n−Ｏ、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−シクロアルキル、ＯＣ（Ｏ）−アルキル−ヘテロシクリル、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＣ（Ｏ）Ｏ−Ｒ１９、ＯＣ（Ｏ）ＮＲ１８Ｒ１８、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−Ｒ３８、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、Ｃ（Ｏ）ＮＲ２０−アルキル、Ｃ（Ｏ）ＮＲ１９−アルキル−Ｒ２１、−Ｃ（Ｏ）ＮＲ１８Ｏ−Ｒ１８、−Ｃ（Ｏ）ＮＲ１８ＮＲ１８Ｒ１８、ＳＯ−アルキル、ＳＯ−アリール、ＳＯ₂−アルキル、ＳＯ₂−アリール、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリール、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、ｎは、１、２もしくは３の値をとることができ、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基及びアルキル−ヘテロアリール置換基は、その側で再び置換されていてよい；
非置換もしくは置換されたヘテロアリール、
その際、前記ヘテロアリール基は、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＣＦ₃、ＣＮ、ＮＨ₂、ＮＨ−アルキル、ＮＨ−Ｒ３８、ＮＨ−シクロアルキル、ＮＨ−ヘテロシクリル、ＮＨ−アリール、ＮＨ−ヘテロアリール、ＮＨ−アルキル−シクロアルキル、ＮＨ−アルキル−ヘテロシクリル、ＮＨ−アルキル−アリール、ＮＨ−アルキル−ヘテロアリール、Ｎ（アルキル）₂、Ｎ（アリール）₂、ＮＲ２０−アルキル、ＮＨＣ（Ｏ）−アルキル、ＮＨＣ（Ｏ）−Ｒ３８、ＮＲ１９（Ｏ）−アルキル、ＮＨＣ（Ｏ）−シクロアルキル、ＮＲ１９Ｃ（Ｏ）−シクロアルキル、ＮＨＣ（Ｏ）−ヘテロシクリル、ＮＲ１９Ｃ（Ｏ）−ヘテロシクリル、ＮＨＣ（Ｏ）−アリール、ＮＲ１９Ｃ（Ｏ）−アリール、ＮＨＣ（Ｏ）−ヘテロアリール、ＮＲ１９Ｃ（Ｏ）−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）−アルキル−シクロアルキル、ＮＲ１８Ｃ（Ｏ）−アルキル−ヘテロシクリル、ＮＨＣ（Ｏ）−アルキル−アリール、ＮＲ１９Ｃ（Ｏ）−アルキル−アリール、ＮＨＣ（Ｏ）−アルキル−ヘテロアリール、ＮＲ１９Ｃ（Ｏ）−アルキル−ヘテロアリール、ＮＲ１８Ｃ（Ｏ）Ｏ−Ｒ１９、ＮＲ１８Ｃ（Ｏ）ＮＲ１８Ｒ１８、ＮＨＳＯ₂−アルキル、ＮＨＳＯ₂−シクロアルキル、ＮＨＳＯ₂−ヘテロシクリル、ＮＨＳＯ₂−アリール、ＮＨＳＯ₂−ヘテロアリール、ＮＨＳＯ₂−アルキル−ヘテロシクリル、ＮＨＳＯ₂−アルキル−アリール、ＮＨＳＯ₂−アルキル−ヘテロアリール、ＮＯ₂、ＳＨ、Ｓ−アルキル、Ｓ−アリール、Ｓ−ヘテロアリール、ＯＨ、ＯＣＦ₃、Ｏ−アルキル、Ｏ−Ｒ３８、Ｏ−シクロアルキル、Ｏ−ヘテロシクリル、Ｏ−アリール、Ｏ−ヘテロアリール、Ｏ−アルキル−シクロアルキル、Ｏ−アルキル−ヘテロシクリル、Ｏ−アルキル−アリール、Ｏ−アルキル−ヘテロアリール、ＯＣ（Ｏ）−アルキル、ＯＣ（Ｏ）−Ｒ３８、ＯＣ（Ｏ）−シクロアルキル、ＯＣ（Ｏ）−ヘテロシクリル、ＯＣ（Ｏ）−アリール、ＯＣ（Ｏ）−ヘテロアリール、ＯＣ（Ｏ）−アルキル−シクロアルキル、ＯＣ（Ｏ）−アルキル−ヘテロシクリル、ＯＣ（Ｏ）−アルキル−アリール、ＯＣ（Ｏ）−アルキル−ヘテロアリール、ＯＣ（Ｏ）Ｏ−Ｒ１９、ＯＣ（Ｏ）ＮＲ１８Ｒ１８、ＯＳＯ₃Ｈ、ＯＳＯ₂−アルキル、ＯＳＯ₂−シクロアルキル、ＯＳＯ₂−ヘテロシクリル、ＯＳＯ₂−アリール、ＯＳＯ₂−ヘテロアリール、ＯＳＯ₂−アルキル−アリール、ＯＳＯ₂−アルキル−ヘテロアリール、ＯＰ（Ｏ）（ＯＨ）₂、ＯＰ（Ｏ）（Ｏアルキル）₂、ＯＰ（Ｏ）（Ｏアリール）₂、Ｃ（Ｏ）−アルキル、Ｃ（Ｏ）−アリール、Ｃ（Ｏ）−ヘテロアリール、ＣＯ₂Ｈ、ＣＯ₂−アルキル、ＣＯ₂−Ｒ３８、ＣＯ₂−シクロアルキル、ＣＯ₂−ヘテロシクリル、ＣＯ₂−アリール、ＣＯ₂−ヘテロアリール、ＣＯ₂−アルキル−シクロアルキル、ＣＯ₂−アルキル−ヘテロシクリル、ＣＯ₂−アルキル−アリール、ＣＯ₂−アルキル−ヘテロアリール、Ｃ（Ｏ）−ＮＨ₂、Ｃ（Ｏ）ＮＨ−アルキル、Ｃ（Ｏ）ＮＨ−Ｒ３８、Ｃ（Ｏ）ＮＨ−シクロアルキル、Ｃ（Ｏ）ＮＨ−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アリール、Ｃ（Ｏ）ＮＨ−ヘテロアリール、Ｃ（Ｏ）ＮＨ−アルキル−シクロアルキル、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロシクリル、Ｃ（Ｏ）ＮＨ−アルキル−アリール、Ｃ（Ｏ）ＮＨ−アルキル−ヘテロアリール、Ｃ（Ｏ）Ｎ（アルキル）₂、Ｃ（Ｏ）Ｎ（シクロアルキル）₂、Ｃ（Ｏ）Ｎ（アリール）₂、Ｃ（Ｏ）Ｎ（ヘテロアリール）₂、Ｃ（Ｏ）ＮＲ２０−アルキル、Ｃ（Ｏ）ＮＲ１９−アルキル−Ｒ２１、−Ｃ（Ｏ）ＮＲ１８Ｏ−Ｒ１８、−Ｃ（Ｏ）ＮＲ１８ＮＲ１８Ｒ１８、ＳＯ₂ＮＨ₂、ＳＯ₂ＮＨ−アルキル、ＳＯ₂ＮＨ−アリール、ＳＯ₂ＮＨ−ヘテロアリール、ＳＯ₂ＮＨ−アルキル−アリール、ＳＯ₃Ｈ、ＳＯ₂Ｏ−アルキル、ＳＯ₂Ｏ−アリール、ＳＯ₂Ｏ−アルキル−アリール、アルキル、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリール、シクロアルキル、ヘテロシクリル、アリールもしくはヘテロアリールで、同一もしくは異なって、一置換もしくは多置換されていてよく、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基及びアルキル−ヘテロアリール置換基は、その側で再び置換されていてよい；
ＯＲ２９、
その際、Ｒ２９は、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基、ヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で置換されていてよい；
ＳＲ３０、
その際、Ｒ３０は、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよく、かつ前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基及びヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で置換されていてよい；
ＮＲ３１Ｒ３２、
その際、Ｒ３１及びＲ３２は、互いに無関係に、水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリール、−Ｃ（Ｏ）−Ｒ３３、−ＳＯ₂Ｒ３３、−Ｃ（Ｏ）ＯＲ３３及び−Ｃ（Ｏ）−ＮＲ３４Ｒ３５であってよく、その際、Ｒ３３は、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリールであってよく、かつＲ３４及びＲ３５は、互いに無関係に、水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリール、アルキル−ヘテロアリールであってよく、又はＲ３４及びＲ３５は、一緒になって、ヘテロシクリル環を形成することができる；
又は、Ｒ３１及びＲ３２は、一緒になって、ヘテロシクリル環を形成することができる、
前記アルキル置換基、シクロアルキル置換基、ヘテロシクリル置換基、アリール置換基及びヘテロアリール置換基、アルキル−シクロアルキル置換基、アルキル−ヘテロシクリル置換基、アルキル−アリール置換基もしくはアルキル−ヘテロアリール置換基は、その側で再び置換されていてよい；
Ｒ１８は、水素、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよい、
Ｒ１９は、アルキル、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよい、
Ｒ２０は、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリール、アルキル−シクロアルキル、アルキル−ヘテロシクリル、アルキル−アリールもしくはアルキル−ヘテロアリールであってよい、
Ｒ２１は、シクロアルキル、ヘテロシクリル、アリール、ヘテロアリールであってよい、
Ｒ３８は、アルキルであってよく、その際、前記アルキル基は、飽和もしくは不飽和、直鎖状もしくは分枝鎖状であってよく、９〜３０個の炭素原子を有する、すなわちＣ₉〜Ｃ₃₀−アルカニル、Ｃ₉〜Ｃ₃₀−アルケニル及びＣ₉〜Ｃ₃₀−アルキニルであるその際、アルケニルは、少なくとも１個のＣ−Ｃ二重結合を有し、かつアルキニルは、少なくとも１個のＣ−Ｃ三重結合を有し、その際、アルケニルは、（Ｅ）立体配置か（Ｚ）立体配置のいずれかで存在することができる。前記アルキル基が、ノニル、デシル、ドデシル、ヘキサデシル、オクタデシル、エイコシル、ヘニコシル、ドコシル、テトラコシル、ノナコシル、オクタデセニル、ドコセニル、テトラコセニル及びオクタデシニルを有する基から選択されることが好ましい］で示される一連のピリド［２，３−ｂ］ピラジンからの新規化合物が記載される。 According to a further aspect, in the present application, the general formula (II)

[Wherein the substituents R1 to R4 have the following meanings:
R1 and R2, independently of one another, denote hydrogen or NR5R6, provided that when R1 is NR5R6, R2 is H and when R2 is NR5R6, R1 is H;
Wherein R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, the alkyl substituent as defined above, A cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent or alkyl-heteroaryl substituent is again on that side, F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF ₃ , O (-alkyl-O ) _p - alkyl, O- aryl, OSO ₃ H, OP ( _{) (OH) 2, OP (} O) (O _{-alkyl) 2, OP (O) (} O _{aryl) 2, CHO, C (O} ) OH, C (O) NH 2, C (O) OR12, C (O ) NHR12, C (O) NR12R13 , SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (O -alkyl) _2, P (O) (O aryl) _2, Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, which may be the same or different, mono- or poly-substituted, and p may have a value of 0, 1, 2, 3, 4 or 5; And the radicals R12 and R13, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl- It may be heteroaryl, or R12 and R13, taken together, may form a heterocyclyl ring;
R6 may mean -C (O) NR9-Y-R10, wherein Y may be O or NR11, independently of each other;
R9 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, and the alkyl substituent, cycloalkyl substituent, A heterocyclyl substituent, an aryl substituent and a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted on that side;
R10 and R11, independently of one another, can have the following meanings:
hydrogen,
Unsubstituted or substituted alkyl,
Unsubstituted or substituted cycloalkyl,
Unsubstituted or substituted heterocyclyl,
In this case, the heterocyclyl group is OH, O-alkyl, O-aryl, NH ₂ , NH-alkyl, NH-aryl, alkyl, alkyl-aryl or aryl, which are the same or different and mono- or poly-substituted. May be;
Unsubstituted or substituted aryl,
In this case, the aryl group includes F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH- alkyl - cycloalkyl, NH- alkyl - heterocyclyl, NH- alkyl - aryl, NH- alkyl - heteroaryl, NH- alkyl -NH _2, NH- alkyl -OH, N (alkyl) _2, NHC (O) - Alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC ( O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heteroaryl Krill, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- cycloalkyl, S- heterocyclyl, S- aryl, S- heteroaryl, OH, OCF _3, O (- alkyl -O) _p - alkyl, O-R38, O- cycloalkyl, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - cycloalkyl, O- alkyl - heterocyclyl, O- alkyl - aryl, O- alkyl - heteroaryl, O- alkyl _{-OH, O (CH 2) n} -O, OC (O) - alkyl, OC (O) -R38, OC ( O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroary , OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OSO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl , OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, C (O) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ H , CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C ( O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl , C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO-alkyl, SO-aryl, SO ₂ -alkyl, SO ₂ -aryl, SO ₂ NH ₂ , SO ₂ NH - alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl, SO ₂ O-alkyl - aryl Alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted, where p takes the value 0, 1, 2, 3, 4 or 5. Can do;
Unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may be F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl. , NH- alkyl - cycloalkyl, NH- alkyl - heterocyclyl, NH- alkyl - aryl, NH- alkyl - heteroaryl, NH- alkyl -NH _2, NH- alkyl -OH, N (alkyl) _2, NHC (O) -Alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - Heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- aryl, S- heteroaryl, OH, OCF ₃ , O (-alkyl-O) _p -alkyl, O-R38, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl -Aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -Heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, SO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) _{(OH) 2, C (O} ) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl , C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) _{) 2, SO 2 NH 2,} SO 2 NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl , SO ₂ O-alkyl - aryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, same or different, it may be mono- or polysubstituted, in which p may take the values of 0, 1, 2 or 5;
Or R10 and R11 can be taken together to form a heterocyclyl ring;
R3 and R4 can have the following meanings independently of each other:
hydrogen,
Hydroxyl,
Halogens such as fluorine, chlorine, bromine, iodine,
Unsubstituted or substituted alkyl,
In this case, the alkyl group includes F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , SH, S-alkyl, OH, OCF ₃ , O (- alkyl -O) _p - alkyl, O- _{aryl, OSO 3 H, OP (O} ) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C ( O) OH, C (O) OR14, C (O) NH 2, C (O) NHR14, C (O) NR14R15, SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (Oalkyl) ₂ , P (O) (Oaryl) ₂ , cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different and mono- or polysubstituted, where p Is 0, 1, 2, 3, 4 or 5 And the groups R14 and R15, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, Well, or R14 and R15 can be taken together to form a heterocyclyl ring;
Unsubstituted or substituted aryl,
In this case, the aryl group includes F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NR20-alkyl, NHC (O) -alkyl, NHC (O) -R38, NR19 (O) -alkyl, NHC (O) -cycloalkyl, NR19C (O) -cycloalkyl, NHC (O) -heterocyclyl, NR19C (O) -heterocyclyl, NHC (O) -aryl, NR19C (O) -aryl, NHC (O) -heteroaryl, NR19C (O) -heteroa NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NHC (O) -alkyl-aryl, NR19C (O) -alkyl-aryl, NHC (O) -alkyl-heteroaryl, NR19C (O) - alkyl - heteroaryl, NR18C (O) O-R19 , NR18C (O) NR18R18, NHSO 2 - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl , NHSO ₂ -alkyl-heterocyclyl, NHSO ₂ -alkyl-aryl, NHSO ₂ -alkyl-heteroaryl, NO ₂ , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF ₃ , O-alkyl, O-R38, O-cycloal Le, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - cycloalkyl, O- alkyl - heterocyclyl, O- alkyl - aryl, O- alkyl - heteroaryl, O- (CH _{2) n} -O , OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O)- Alkyl-cycloalkyl, OC (O) -alkyl-heterocyclyl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, OC (O) O-R19, OC (O) NR18R18, OSO ₃ H , OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C (O) - alkyl , C (O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - hetero aryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C ( O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH- Alkyl - cycloalkyl, C (O) NH- alkyl - heterocyclyl, C (O) NH- alkyl - aryl, C (O) NH- alkyl - heteroaryl, C (O) N (alkyl) _2, C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , C (O) NR20-alkyl, C (O) NR19-alkyl-R21, -C (O ) NR18O-R18, -C (O ) NR18NR18R18, SO- alkyl, SO- aryl, SO ₂ - alkyl, SO ₂ - _{aryl, SO 2 NH 2, SO 2} NH- alkyl, SO ₂ NH- aryl, SO ₂ NH - heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl, SO ₂ O-alkyl - aryl, alkyl, alkylene -Cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted and n is 1, 2 or 3 and the alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent. Groups and alkyl-heteroaryl substituents may be substituted again on that side;
Unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may be F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl. , NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NR20-alkyl, NHC (O) -alkyl, NHC (O) -R38, NR19 (O) -alkyl, NHC (O) -cycloalkyl, NR19C (O) -cycloalkyl, NHC (O) -heterocyclyl, NR19C (O) -heterocyclyl, NHC (O) -aryl , NR19C (O) -aryl, NHC (O) -heteroaryl, NR19C (O) -he Roaryl, NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NHC (O) -alkyl-aryl, NR19C (O) -alkyl-aryl, NHC (O) -alkyl-heteroaryl, NR19C (O) - alkyl - heteroaryl, NR18C (O) O-R19 , NR18C (O) NR18R18, NHSO 2 - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - heterocyclyl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- aryl, S- heteroaryl, OH, OCF _3, O- alkyl, O -R38, O-Siku Alkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC ( O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-cycloalkyl, OC (O)- alkyl - heterocyclyl, OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OC (O) O-R19 , OC (O) NR18R18, OSO 3 H, OSO 2 - alkyl, OSO ₂ - cyclo alkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl Le - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C (O) - alkyl, C ( O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C (O) NH -R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cyclo Alkyl, C (O) NH- alkyl - heterocyclyl, C (O) NH- alkyl - aryl, C (O) NH- alkyl - heteroaryl, C (O) N (alkyl) _2, C (O) N (cyclo Alkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , C (O) NR20-alkyl, C (O) NR19-alkyl-R21, -C (O) NR18O- R18, -C (O) NR18NR18R18, SO 2 NH 2, SO 2 NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl , SO ₂ O-aryl, SO ₂ O-alkyl - aryl, alkyl, alkyl - cycloalkyl, alkyl - heterocyclyl, alkyl - aryl, alkyl - heteroar- , Cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or poly-substituted, and the alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl Substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents may be substituted again on that side;
OR29,
R29 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, and said alkyl substituent, cycloalkyl substituent A heterocyclyl substituent, an aryl substituent, a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted on that side;
SR30,
R30 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, and the alkyl substituent, cycloalkyl substituent. A heterocyclyl substituent, an aryl substituent and a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted on that side;
NR31R32,
In this case, R 31 and R 32 are independently of each other hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, —C (O) — R33, -SO ₂ R33, -C (O) OR33 and -C (O) may be -NR34R35, this time, R33 is alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl - cycloalkyl, alkyl -Heterocyclyl, alkyl-aryl, alkyl-heteroaryl and R34 and R35 independently of one another are hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-hetero Krill, alkyl - aryl, alkyl - may be a heteroaryl, or R34 and R35 taken together may form a heterocyclyl ring;
Or, R31 and R32 can be taken together to form a heterocyclyl ring,
The alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent or alkyl-heteroaryl substituent are: May be substituted again on that side;
R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl.
R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl,
R38 may be alkyl, wherein the alkyl group may be saturated or unsaturated, linear or branched and has ₉ to 30 carbon atoms, ie C ₉ -C ₃₀ - alkanyl, C ₉ -C ₃₀ - alkenyl and C ₉ -C ₃₀ - that time is alkynyl, alkenyl has at least one C-C double bond and alkynyls at least one C It has a -C triple bond, in which alkenyl can be present in either (E) or (Z) configuration. The alkyl group is preferably selected from the group having nonyl, decyl, dodecyl, hexadecyl, octadecyl, eicosyl, henicosyl, docosyl, tetracosyl, nonacosyl, octadecenyl, dococenyl, tetracocenyl and octadecynyl]. New compounds from 2,3-b] pyrazine are described.

  A pyrido [2,3-b] pyrazine derivative represented by the general formula (II) in which R2 is H is particularly preferred.

  Furthermore, a pyrido [2,3-b] pyrazine derivative represented by the general formula (II) in which R2 and R4 are H is particularly preferred.

Particularly preferred are the following pyrido [2,3-b] pyrazine derivatives of the general formulas (I) and (II), which are in the form of free bases or physiologically acceptable acids. It may exist as a pharmaceutically acceptable salt:
Compound 1 1-ethyl-3- (3-phenylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 2 1-ethyl-3- (3-thiophen-3-ylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 3 1- (3-Cyclopropylethynyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea

Compound 4 1- [3- (3-Dimethylamino-prop-1-ynyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 5 1- [3-((E) -2-cyclohexyl-vinyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 6 1-ethyl-3- [3-((E) -3-methoxy-propenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 7

Compound 8

Compound 9 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester methyl ester

Compound 10 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester

Compound 11 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester Phenyl ester

Compound 12 Diethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 13 (E) -3-Phenyl-acrylic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 14 Nonadecanoic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 15 1- (3-Benzyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea

Compound 16 Carbonic acid 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester

Compound 17 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester isobutyl ester

Compound 18 Carbonic acid but-2-ynyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 19 Dimethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 20 Ethyl-carbamic acid 4- [6- (3-ethyl-1-phenyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 21 {4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid t-butyl ester

Compound 22 {4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid 2-methoxy-ethyl ester

Compound 23 1-ethyl-3- {3- [4- (3-ethyl-urea) -phenyl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 24 1- {3- [4- (3,3-Dimethyl-urea) -phenyl] -pyrido [2,3-b] pyrazin-6-yl} -3-ethyl-urea

Compound 25 1-ethyl-3- {3- [6- (3-ethyl-urea) -pyridin-3-yl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 26 1-ethyl-3- {3- [2- (4-fluoro-phenyl) -ethyl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 27 1-ethyl-3- {3-[(E) -2- (4-fluoro-phenyl) -vinyl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 28 1-ethyl-3- [3- (4-morpholin-4-ylmethyl-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 29 1-ethyl-3- (3- {4- [2- (2-methoxy-ethoxy) -ethoxy] -phenyl} -pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 30 N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -2- (2-methoxy-ethoxy) -acetamide

Compound 31 N- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -4-methyl-benzamide

Compound 32 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester 2-methoxy-ethyl ester

Compound 33 Carbonic acid 2-benzyloxy-ethyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 34 Carbonic acid 2-benzyloxy-ethyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester

Compound 35 2-Benzyloxy-N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -acetamide

Compound 36 1- [4- (t-Butyl-dimethyl-silanyloxy) -butyl] -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 37 1- [4- (t-Butyl-dimethyl-silanyloxy) -butyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl ] -Urea

Compound 38 Ethyl-carbamic acid 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 39 Carbonic acid methyl ester 4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 40 Carbonic acid 2,2-dimethyl- [1,3] dioxolan-4-ylmethyl ester 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 41 Carbonic acid 2,3-dihydroxy-propyl ester 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 42 {4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphoric acid diethyl ester

Compound 43 {4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphate

Compound 44 (4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea} -butyl) -phosphoric acid diethyl ester

Compound 45 (4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea} -butyl) -phosphoric acid

Compound 46 1-ethyl-3- [3- (3-trimethylsilanyl-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 47 1- [3- (4-cyclohexyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 48 1-ethyl-3- [3- (4-methanesulfonyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 49 N- {5- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -2-methyl-phenyl} -methanesulfonamide

Compound 50 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -N-methyl-benzamide

Compound 51 1-ethyl-3- [3- (4-piperidin-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 52 1-ethyl-3- [3- (4-thiophen-3-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 53 N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -phenyl} -acetamide

Compound 54 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -benzoic acid ethyl ester

Compound 55 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester hydrochloride

Compound 56 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester p-toluenesulfonate

Compound 57 Carbonic acid 4- {6- [3- (4-hydroxy-butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester

Compound 58 Carbonic acid 4- {6- [3- (4-hydroxy-butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester hydrochloride

Compound 59 N- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalic acid monoamide ethyl ester

Compound 60 N-ethyl-N '-(3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalamide

Compound 61

Compound 62 {2- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -ethyl} -phosphoric acid diethyl ester

Compound 63 {2- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -ethyl} -phosphate

Compound 64 1- [3- (2-Diethylamino-ethoxy) -propyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- urea

Compound 65 2,2-dimethyl-propanoic acid (2,2-dimethyl-propionyloxymethoxy)-(4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b ] Pyrazin-6-yl] -urea} -butyl) -phosphinoyloxymethyl ester

Compound 66 Acetic acid 1-[(1-acetoxy-ethoxy)-(4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- Urea} -butyl) -phosphinoyloxy] -ethyl ester

Compound 67 Diethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester

Compound 68 Diethyl-carbamic acid 2-chloro-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -6-methoxy-phenyl ester

Compound 69 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester 2- [2- (2-methoxy-ethoxy)- Ethoxy] -ethyl ester

Compound 70 1-ethyl-3- {3- [4- (morpholine-4-sulfonyl) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 71 5- [6- (3-Ethyl-ureido) -pyrido [2,3-b] pyrazin-3-ylamino] -2-hydroxy-benzoic acid ethyl ester

Compound 72 1- [3- (3-Diethylaminomethyl-4-hydroxy-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 73 1-ethyl-3- [3- (6-morpholin-4-yl-pyridin-3-ylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 74 1-ethyl-3- {3- [3- (1H-tetrazol-5-yl) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 75 1-ethyl-3- [3- (3-morpholin-4-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 76 1-ethyl-3- [3- (4-imidazol-1-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 77 1-ethyl-3- [3- (4-pyrrolidin-1-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 78 1-ethyl-3- {3- [4- (4-methyl-piperazin-1-yl) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 79 1-ethyl-3- [3- (3-piperidin-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 80 1-ethyl-3- [3- (4-morpholin-4-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 81 1- {3- [3- (2-cyclohexyl-ethoxy) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -3-ethyl-urea

Compound 82 1-ethyl-3- [3- (3- [1,2,4] triazol-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 83 Carbonic acid 2,2-dimethyl- [1,3] dioxolan-4-ylmethyl ester 4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazine -6-yl] -ureido} -butyl ester

Compound 84 Carbonic acid 2,3-dihydroxy-propyl ester 4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -ureido} -butyl ester

Compound 85 1- [3- (2-Diethylamino-ethoxy) -propyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- urea

  In order to avoid ambiguity, when the chemical structure and chemical name of the above-described explicit compounds do not match each other due to 瑕疵, each chemical structure should uniquely define the explicit compound.

  The general compounds of the above general formulas (I) and (II) and preferred embodiments and the explicitly mentioned pyridopyrazine compounds 1 to 85 are hereinafter commonly referred to as “compounds according to the invention”.

The expressions and concepts presented for the description of the compounds according to the invention basically have the following meanings unless expressly indicated otherwise in the description or in the claims:
The expression “alkyl”, within the scope of the present invention, is an acyclic, saturated or unsaturated hydrocarbon group, which may be branched or straight chain and contains 1 to 8 carbon atoms. Groups having C ₁ -C ₈ -alkanyl, C ₂ -C ₈ -alkenyl and C ₂ -C ₈ -alkynyl. Wherein alkenyl has at least one C—C double bond and alkynyl has at least one C—C triple bond. However, alkynyl may additionally have at least one C—C double bond. Preferred alkyl groups are methyl, ethyl, n-propyl, 2-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, 2-hexyl, n-heptyl, n - octyl, n- nonyl, n- decyl, n- undecyl, n- dodecyl, Echirueniru (vinyl), ethynyl, propenyl _{(-CH 2 CH = CH 2;} -CH = CH-CH 3, -C (= CH 2 ) —CH ₃ ), propynyl (—CH ₂ —C≡CH, —C≡C—CH ₃ ), butenyl, butynyl, pentenyl, pentynyl, hexenyl, hexynyl, heptenyl, heptynyl, octenyl, octadienyl and octynyl.

The expression “C ₉ -C ₃₀ -alkyl”, within the scope of the present invention, is acyclic, branched or straight chain, has ₉ to ₃₀ carbon atoms, saturated or unsaturated. Saturated hydrocarbon groups are described, ie C ₉ -C ₃₀ -alkanyl, C ₉ -C ₃₀ -alkenyl and C ₉ -C ₃₀ -alkynyl. C ₉ -C ₃₀ -alkenyl in that case has at least one C—C double bond, and C ₉ -C ₃₀ -alkynyl has at least one C—C triple bond. However, C ₉ -C ₃₀ -alkynyl may additionally also have at least one C—C double bond. Preferred C ₉ -C ₃₀ -alkyl groups are tetradecyl, hexadecyl, octadecyl, eicosanyl, cis-13-docosenyl (erucyl), trans-13-docosenyl (brassyl), cis-15-tetracocenyl (nerbornyl) and trans-15- Tetracosenyl.

The expression “cycloalkyl” is, for the purposes of the present invention, cyclic, non-aromatic, 3 to 3 carbon atoms, preferably 1 to 3 carbon atoms having 3 to 12 carbon atoms. By hydrocarbons having a ring, which may be saturated or unsaturated, particularly preferably C ₃ -C ₈ -cycloalkyl is meant. Cycloalkyl groups also include, for example, bicyclic or polycyclic cycloalkyl groups fused to an aryl group, heteroaryl group, or heterocyclyl group, as defined herein, with each possible and desired ring member. It may be part of a cyclic system. The coupling to the compounds of the general formulas (I), (II) may be carried out via each possible ring member of the cycloalkyl group. Preferred cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclodecyl, cyclohexenyl, cyclopentenyl and cyclooctadienyl.

  The expression “heterocyclyl” is a 3- to 14-membered, preferably 3-, 4-membered, 5-membered, 6-membered, 7-membered or 8-membered cyclic organic group, comprising at least one, optionally 2 A group comprising one, three, four or five heteroatoms, in particular nitrogen, oxygen and / or sulfur, wherein the heteroatoms are identical or different and are saturated or unsaturated but not aromatic Represents. Also, a heterocyclyl group can be, for example, a bicyclic or polycyclic ring in which the heterocyclyl group is fused with an aryl, heteroaryl or cycloalkyl group as defined herein by each possible and desired ring member. It may be part of a system of formulas. The coupling to the compounds of the general formulas (I), (II) may be effected via each possible ring member of the heterocyclyl group. Preferred heterocyclyl groups are tetrahydrofuryl, pyrrolidinyl, imidazolidinyl, thiazolidinyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiapyrrolidinyl, oxapiperazinyl, oxapiperidinyl and oxadiazolyl.

  The expression “aryl” in the context of the present invention is an aromatic hydrocarbon having 3 to 14 carbon atoms, preferably 5 to 14 carbon atoms, particularly preferably 6 to 14 carbon atoms. Means. An aryl group is, for example, an aryl group as defined herein with a heterocyclyl, heteroaryl or cycloalkyl group such as tetrahydrofuran, tetrahydrothiophene, pyrrolidine, imidazolidine, thiazolidine, tetrahydropyran, dihydropyran, piperidine, furan , Thiophene, imidazole, thiazole, oxazole, isoxazole, and part of a bicyclic or polycyclic system fused with each possible and desired ring member. The coupling to the compounds of the general formulas (I), (II) may be carried out via each possible ring member of the aryl group. Preferred aryl groups are phenyl, biphenyl, naphthyl and anthracenyl, but likewise indanyl, indenyl or 1,2,3,4-tetrahydronaphthyl.

  The expression “heteroaryl” is a 5-membered, 6-membered or 7-membered cyclic aromatic group, comprising at least one, optionally also two, three, four or five heteroatoms, in particular nitrogen, Represents a group having oxygen and / or sulfur, wherein the heteroatoms are the same or different. The number of nitrogen atoms is preferably 0 to 3, and the number of oxygen and sulfur atoms is preferably 0 or 1. A heteroaryl group also includes, for example, a bicyclic or polycyclic heteroaryl group fused with a heterocyclyl group, an aryl group, or a cycloalkyl group, as defined herein, with each possible and desired ring member. It may be part of a cyclic system. The coupling to the compounds of the general formulas (I), (II) may be carried out via each possible ring member of the heteroaryl group. Preferred heteroaryl groups are pyrrolyl, furyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, pyrazolyl, imidazolyl, triazole, tetrazole, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazine, phthalazinyl, indolyl, indazolyl, indolidinyl, quinolinyl Isoquinolinyl, quinoxalinyl, quinazolinyl, pteridinyl, carbazolyl, phenazinyl, phenoxazinyl, phenothiazinyl and acridinyl.

The expressions “alkyl-cycloalkyl”, “cycloalkylalkyl”, “alkyl-heterocyclyl”, “heterocyclylalkyl”, “alkyl-aryl”, “arylalkyl”, “alkyl-heteroaryl” and “heteroarylalkyl” For the purposes of the present invention, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl have the meanings given above, and cycloalkyl, heterocyclyl, aryl and heteroaryl groups are alkyl groups, preferably Means that it is bound to a compound of the general formula (I) or (I) via a C ₁ -C ₈ -alkyl group, particularly preferably a C ₁ -C ₄ -alkyl group.

Related to “alkyl”, “cycloalkyl”, “heterocyclyl”, “aryl”, “heteroaryl”, “alkyl-cycloalkyl”, “alkyl-heterocyclyl”, “alkyl-aryl” and “alkyl-heteroaryl” The concept of substituted is within the scope of the present invention, unless expressly defined in the foregoing specification or in the claims, of one or more hydrogen groups, F, Cl, Br. _{, I, CN, CF 3,} NH 2, NH- alkyl, NH- aryl, N _{(alkyl) 2, NO 2, SH,} S- _{alkyl, OH, OCF 3, O (} - alkyl -O) _p - alkyl, O- _{aryl, OSO 3 H, OP (O} ) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O _{aryl) 2, CHO, C (O} ) OH, C (O) OR36 _{, C (O) NH 2,} C O) NHR36, C (O) NR36R37, SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (O _{-alkyl) 2, P (O) (} O -alkyl) ₂ , Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl. Here, p can take the values 0, 1, 2, 3, 4 or 5 and the radicals R36 and R37, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl- It can be cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, and R36 and R37 can be taken together to form a heterocyclyl ring. The substituents may be the same or different, and the substitution is performed at any possible position of each of an alkyl group, a cycloalkyl group, a heterocyclyl group, an aryl group, and a heteroaryl group.

  The expression “halogen”, within the scope of the present invention, includes the halogen atoms fluorine, chlorine, bromine and iodine.

The polysubstituted group represents a group that is polysubstituted by different atoms or by the same atom, for example, a disubstituted or trisubstituted group, and is the same as in the case of CF ₃ , —CH ₂ CF ₃ , for example. Or a group substituted with a different atom as in the case of —CH (OH) —CH═CH—CHCl ₂ . Multiple substitutions can be made with the same or different substituents.

  If the compounds according to the invention have at least one asymmetric center, the compounds are in racemic form, pure enantiomers and / or diastereomers or mixtures of enantiomers and / or diastereomers, In itself, in particular, it can exist as a pharmaceutically acceptable salt of said compound. This mixture can be present in any mixing ratio of the stereoisomers.

  For example, a compound according to the invention having one or more chiral centers and existing as a racemate can be separated into optical isomers, ie enantiomers or diastereomers, by methods known per se. This separation may be accomplished by column separation in a chiral phase or by recrystallization from an optically active solution, using optically active acids or bases, or by derivatization with optically active reagents such as optically active alcohols, and subsequent residues. It can be done by separation.

  The compounds according to the invention may exist in the form of their double bond isomers as “pure” E or Z isomers or in the form of mixtures of these double bond isomers.

  If possible, the compounds according to the invention can exist in tautomeric forms.

  The compounds according to the invention can be converted into their physiologically acceptable salts using inorganic and organic acids when they have a sufficiently basic group, for example a primary, secondary or tertiary amine. can do. Pharmaceutically acceptable salts of the compounds according to the invention include hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, p-toluenesulfonic acid, carbonic acid, formic acid, acetic acid, trifluoroacetic acid, sulfoacetic acid, Formed with oxalic acid, malonic acid, maleic acid, succinic acid, tartaric acid, glucose acid, malic acid, embonic acid, mandelic acid, fumaric acid, lactic acid, citric acid, glutamic acid or aspartic acid. The salts produced are, among others, hydrochloride, hydrobromide, sulfate, hydrogen sulfate, phosphate, methanesulfonate, tosylate, carbonate, bicarbonate, formate, acetate, triflate , Sulfoacetic acid, oxalate, malonate, maleate, succinate, tartrate, malate, embonate, mandelate, fumarate, lactate, citrate, glutamate and asparagine Acid salt. The stoichiometry of the salts produced of the compounds according to the invention is in this case an integer multiple of 1 or a non-integer multiple of 1.

  The compounds according to the invention can be converted into physiologically acceptable salts using inorganic and organic bases when they have a sufficiently acidic group, for example a carboxyl group or a phosphate group. Examples of the inorganic base include sodium hydroxide, potassium hydroxide and calcium hydroxide, and examples of the organic base include ethanolamine, diethanolamine, triethanolamine, cyclohexylamine, dibenzylethylenediamine and lysine. The stoichiometry of the salts produced of the compounds according to the invention is in this case an integer multiple of 1 or a non-integer multiple of 1.

  Preference is likewise given to solvates, in particular hydrates, of the compounds according to the invention which can be obtained, for example, by crystallization from solvents or aqueous solutions. In this case, 1, 2, 3 or any number of solvent molecules or water molecules can be combined with the compounds according to the invention to form solvates and hydrates.

  It is known that chemicals form solids that exist in a variety of ordered states expressed as polymorphs or transformations. The various transformations of polymorphic substances differ significantly in their physical properties. The compounds according to the invention may exist in different crystalline polymorphs, in which case the defined transformation may be metastable.

  Similarly, the compounds according to the invention may be present in any prodrug form, for example in the form of esters, carbonates, carbamates, ureas, amides or phosphates, in which case virtually biological The active form is only released by metabolism.

  It is known that chemicals can be transformed in the body to become metabolites that can possibly cause the desired biological action (even in a strong and distinct form in some circumstances).

  The corresponding prodrugs and metabolites of the compounds according to the invention should be regarded as suitable for the invention.

  Surprisingly and preferably, it has now been found that the compounds according to the invention can also influence two or more signaling pathways or enzymes of such pathways, or can act in a regulatory or inhibitory manner. . In doing so, it has been found that the compounds according to the invention have an effect with high selectivity or act in a regulated or inhibitory manner.

  Two or more signaling pathways, such as ras-Raf-Mek-Erk-signaling pathway, PI3K-Akt-signaling pathway and / or SAPK-signaling pathway, specific Erk1 / Erk2 and / or PI3K and / or Jnk and / or Such simultaneous, eg, dual modulation or inhibition of p38 is preferred over the modulation or inhibition of only one signaling pathway. This is because it can lead to synergistic therapeutic effects such as enhanced apoptosis and rapid and effective tumor regression.

  Unexpectedly preferred effects according to the present invention are sensitive to the treatment or modulation of two or more signaling pathways, or in physiological and / or pathophysiological conditions mediated by two or more signaling pathways. Enables the pursuit of multiple treatment formulations.

  Furthermore, unexpectedly and preferably, the compounds according to the invention can also affect the ras-Raf-Mek-Erk-signaling pathway or its enzymes with high selectivity or act in a regulatory or inhibitory manner. In addition, it was confirmed that the above-mentioned multi-action mechanism and multiple therapeutic preparations can also be used for this signal pathway or enzyme.

  Furthermore, unexpectedly and preferably, the compounds according to the invention can also influence the PI3K-Akt-signaling pathway or its enzymes with high selectivity or act in a regulatory or inhibitory manner, It has been confirmed that multiple action mechanisms and multiple therapeutic formulations can also be used for this signaling pathway or enzyme.

  Furthermore, surprisingly and preferably, the compounds according to the invention can also influence the SAPK-signaling pathway or its enzymes with high selectivity, or act in a regulatory or inhibitory manner, as described above. It was confirmed that the mechanism of action and multiple therapeutic formulations can also be used with this signaling pathway or enzyme.

  Furthermore, unexpectedly and preferably, the compounds according to the invention also affect the enzymes such as ATM, ATR, mTOR, DNA-PK and / or hSMG-1 with high selectivity, or are regulated or inhibitory. It was confirmed that the above-mentioned multiple action mechanism and multiple therapeutic preparations can also be used for these enzymes.

  The concept “regulation” represents according to the invention the following “activation, partial activation, inhibition, partial inhibition”. In this case, it is within the expert knowledge of the average expert to measure and test such activation, partial activation, inhibition or partial inhibition by conventional measurement methods and assays. Here, partial activation can be measured and assayed for complete activation, for example, and similarly partial inhibition can be measured and assayed for complete inhibition.

  The concept “inhibition” represents according to the invention the following “partial or complete inhibition”. In this case, it is within the average expert expertise to measure and test such partial or complete inhibition by conventional measurement methods and assays. Here, partial inhibition can be measured and assayed for complete inhibition, for example.

  The concepts “modulation” and “inhibition” are within the scope of the present invention in the context of “enzymes” and / or “kinases” and are inactive forms (enzymatically inactive) of the respective enzymes and / or kinases. And / or active form (enzymatically active). This means that, within the scope of the present invention, the compounds according to the invention can exert a regulating action in the inactive form, in the active form, or in both forms of the enzyme and / or kinase.

  The object of the invention has been solved in a further aspect, surprisingly, by providing a medicament comprising at least one compound according to the invention.

  The subject of the present invention is, in a further aspect, surprisingly at least one compound according to the invention and at least one other pharmaceutical agent and / or pharmaceutically acceptable carrier substance and It has been solved by providing medicinal products containing in combination with / or auxiliary substances.

  The subject of the present invention is, in a further aspect, surprisingly, a pharmaceutical preparation comprising, surprisingly, one or more compounds according to the invention and a pharmaceutically acceptable carrier substance and / or auxiliary substance processed. Or a pharmaceutical manufacturing method characterized in that it is in a pharmaceutically usable form.

  The subject of the present invention is, in a further aspect, surprisingly, as an agent, especially for the modulation of mis-routed cell signaling pathways, particularly active and inactive receptor-tyrosine kinases, and cytoplasm. Tyrosine kinases, serine / threonine kinases and lipid kinases such as c-Raf, B-Raf, Mek, MAPK, PDGFRβ, Flt-3, IGF1R, PI3K, PKB / Akt1, c-Kit, c-Abl, FGFR1 and KDR It has been solved by providing a compound according to the invention that can be used in medicine to affect function.

  The subject of the invention, in a further aspect, can be surprisingly used for the manufacture of a medicament for the treatment or prevention of physiological and / or pathophysiological conditions in mammals, In this case, the treatment or prevention is one or more signals selected from the group consisting of “ras-Raf-Mek-Erk-signaling pathway, PI3K-Akt-signaling pathway and / or SAPK-signaling pathway” It has been solved by providing the compounds according to the invention brought about by modulation of the transmission pathway.

  In a further aspect, the subject of the invention is surprisingly a physiological in mammals mediated by an enzyme selected from the group consisting of “ATM, ATR, mTOR, DNA-PK, hSMG-1”. It has been solved by providing a compound according to the invention which can be used for the manufacture of a medicament for the treatment or prevention of clinical and / or pathophysiological conditions.

  In a further aspect, the subject of the invention can surprisingly be used for the manufacture of a medicament for the treatment or prevention of physiological and / or pathophysiological conditions in mammals, In doing so, by providing a compound according to the invention wherein the treatment or prevention is effected by the modulation of one or more enzymes selected from the group consisting of “ATM, ATR, mTOR, DNA-PK, hSMG-1” It was solved.

  In one preferred embodiment, the compound according to the invention is a physiological and / or pathophysiological condition in mammals mediated by the ras-Raf-Mek-Erk- and PI3K-Akt-signaling pathways. For the manufacture of a medicament for the treatment and / or prevention of and / or for the treatment or prevention of a physiological and / or pathophysiological condition in a mammal, wherein the treatment or prevention is ras Provided for use for the manufacture of a medicament brought about by the modulation of the Raf-Mek-Erk- and PI3K-Akt-signaling pathways.

  In a further aspect, the subject of the invention is surprisingly a treatment of a physiological and / or pathophysiological condition in a mammal mediated by the ras-Raf-Mek-Erk-signaling pathway. Alternatively, it has been solved by providing a compound according to the invention which can be used for the manufacture of a medicament for prevention.

  In a further aspect, the subject of the present invention is surprisingly for the treatment or prevention of physiological and / or pathophysiological conditions in mammals mediated by the PI3K-Akt-signaling pathway. This has been solved by providing the compounds according to the invention which can be used for the manufacture of pharmaceuticals.

  In a further aspect, the subject of the invention can surprisingly be used for the manufacture of a medicament for the treatment or prevention of physiological and / or pathophysiological conditions in mammals, In so doing, the treatment or prevention has been solved by providing the compounds according to the invention brought about by modulation of the PI3K-Akt-signaling pathway.

  In a preferred embodiment, the compounds according to the invention treat and / or prevent physiological and / or pathophysiological conditions in mammals mediated by the SAPK- and PI3K-Akt-signaling pathways. For the manufacture of a medicament for and / or for the treatment or prevention of a physiological and / or pathophysiological condition in a mammal, wherein the treatment or prevention comprises the SAPK-signaling pathway and PI3K -Provided for use for the manufacture of a medicament brought about by modulation of the Akt-signaling pathway.

  In a further aspect, the subject of the present invention is surprisingly a medicament for the treatment or prevention of physiological and / or pathophysiological conditions in mammals mediated by the SAPK-signaling pathway. This has been solved by providing the compounds according to the invention which can be used for the preparation of

  In a further aspect, the subject of the invention can surprisingly be used for the manufacture of a medicament for the treatment or prevention of physiological and / or pathophysiological conditions in mammals, In so doing, the treatment or prevention has been solved by providing the compounds according to the invention brought about by modulation of the SAPK-signaling pathway.

  In a preferred embodiment, the compounds according to the invention have the modulation of the ras-Raf-Mek-Erk-signaling pathway "tyrosine kinase, serine / threonine kinase, receptor-tyrosine kinase, cytoplasmic tyrosine kinase, cytoplasmic serine / threonine Provided for use as described above resulting from the preparation of one or more enzymes selected from the group consisting of “kinases”, preferably selected from the group consisting of “Erk, Erk1, Erk2”.

  In a further preferred embodiment, the compounds according to the invention have a PI3K-Akt-signaling pathway modulation selected from the group consisting of “lipid kinases”, preferably “PI3K, PI3Kα, PI3Kβ, PI3Kγ, Provided for the above uses resulting from the modulation of one or more enzymes selected from the group consisting of PI3Kδ, PI3K-C2α, PI3K-C2β, PI3K-Vps34p ".

  In a preferred embodiment, the compounds according to the invention have the modulation of the SAPK-signaling pathway from the group consisting of “tyrosine kinase, serine / threonine kinase, receptor-tyrosine kinase, cytoplasmic tyrosine kinase, cytoplasmic serine / threonine kinase”. Provided for the use as described above which is effected by the selection of one or more enzymes selected from the group consisting of “Jnk, Jnk1, Jnk2, Jnk3, p38, p38α, p38β, p38γ, p38δ” Is done.

  In a further aspect, the subject of the invention can surprisingly be used for the manufacture of a medicament for the treatment or prevention of physiological and / or pathophysiological conditions in mammals, In so doing, the treatment or prevention has been solved by providing the compounds, preferred embodiments and uses according to the invention according to the above-mentioned aspects resulting from the modulation of two or more enzymes.

  In a further preferred embodiment, the compound according to the invention is selected from the group consisting of “Erk, Erk1, Erk2”, in the treatment or prevention provided by the modulation of two or more enzymes, and At least one enzyme is provided for the above use selected from the group consisting of “PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K-C2α, PI3K-C2β, PI3K-Vps34p”.

  In a further preferred embodiment, the compounds according to the invention have, in the treatment or prevention provided by the modulation of two or more enzymes, at least one enzyme "Jnk, Jnk1, Jnk2, Jnk3, p38, p38α, p38β, p38γ, p38δ ”and at least one enzyme is selected from the group consisting of“ PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K-C2α, PI3K-C2β, PI3K-Vps34p ” Provided for use.

  In a further preferred embodiment, the compound according to the invention is selected from the group consisting of “Erk, Erk1, Erk2”, in the treatment or prevention provided by the modulation of two or more enzymes, and At least one enzyme is provided for the above use selected from the group consisting of “ATM, ATR, mTOR, DNA-PK, hSMG-1”.

  In a further preferred embodiment, the compounds according to the invention have, in the treatment or prevention provided by the modulation of two or more enzymes, at least one enzyme "Jnk, Jnk1, Jnk2, Jnk3, p38, p38α, p38β, p38γ, p38δ "is selected from the group consisting of" and at least one enzyme is provided for the above use selected from the group consisting of "ATM, ATR, mTOR, DNA-PK, hSMG-1".

  In a further preferred embodiment, the compounds according to the invention have, in the treatment or prevention provided by the modulation of two or more enzymes, at least one enzyme is “PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K-C2α, For the above use, selected from the group consisting of "PI3K-C2β, PI3K-Vps34p" and at least one enzyme is selected from the group consisting of "ATM, ATR, mTOR, DNA-PK, hSMG-1" Provided.

  In a further preferred embodiment, the compounds according to the invention are provided for the above uses where the modulation is inhibition.

  The compounds according to the invention can be administered for the treatment and / or prophylaxis within the scope of the invention to all known mammals, in particular humans.

  In another preferred embodiment, the compound according to the invention is a mammal which is “human, useful animal, domestic animal, pet, cow, cow, sheep, pig, goat, horse, pony, donkey, mule, mule, Provided for use as described above, preferably a human being, selected from the group consisting of “rabbit, rabbit, cat, dog, guinea pig, hamster, rat, mouse”.

  The compounds according to the invention can be used within the scope of the invention for the treatment and / or prevention of all known physiological and / or pathophysiological conditions.

  In a preferred embodiment, the compounds according to the invention have a physiological and / or pathophysiological state of “malignant tumor, benign tumor, inflammatory disease, inflammation, pain, rheumatic disease, arthritic disease, HIV. Infection, neurological or neurodegenerative disease, rheumatism, arthritis, AIDS, ARC (AIDS-related syndrome), Kaposi's sarcoma, tumor starting from brain and / or nervous system and / or brain membrane, dementia, Alzheimer, hyperproliferative disease , Psoriasis, endometriosis, scar formation, benign prostatic hypertrophy (BPH), immune system disease, autoimmune disease, immunodeficiency disease, colon tumor, stomach tumor, intestinal tumor, lung tumor, pancreatic tumor, ovarian tumor, prostate tumor , Leukemia, melanoma, liver tumor, kidney tumor, head tumor, cervical tumor, glioma, breast cancer, uterine cancer, endometrial cancer, cervical cancer, brain tumor, adenocanoma (Aden) okanthom), bladder cancer, stomach tumor, colorectal tumor, esophageal cancer, gynecological tumor, ovarian tumor, thyroid cancer, lymphoma, chronic leukemia, acute leukemia, restenosis, diabetes, diabetic nephropathy, fibrotic disease, cyst Fibrosis, malignant nephrosclerosis, thrombotic microvascular syndrome, organ graft-rejection, glomerulopathy, metabolic disease, solid tumor, rheumatoid arthritis, diabetic retinopathy, asthma, allergy, allergic disease, Chronic obstructive pulmonary disease, inflammatory bowel disease, fibrosis, atherosclerosis, heart disease, cardiovascular disease, myocardial disease, vascular disease, angiogenic disease, kidney disease, rhinitis, severe disease, focal ischemia , Heart failure, ischemia, cardiac hypertrophy, renal failure, cardiomyocyte dysfunction, hypertension, vascular stenosis, stroke, anaphylactic shock, platelet coagulation, skeletal muscle atrophy, adiposity, overweight, glucose homeostasis, depression Sex heart failure, angina, heart attack, myocardial infarction, hyperglycemia, hypoglycemia, are provided for the use selected from the group consisting of hypertension ".

  In a further aspect of the present invention, the object of the present invention is surprisingly the use of the compounds according to the invention according to the above aspects, preferred embodiments and uses, physiological and / or pathophysiological in mammals. It has been solved by providing for use in the manufacture of a medicament for the treatment or prevention of a condition comprising at least one other pharmacologically active substance.

  In a further aspect of the present invention, the object of the present invention is surprisingly the use of the compounds according to the invention according to the above aspects, preferred embodiments and uses, physiological and / or pathophysiological in mammals. Provided for use in the manufacture of a medicament for the treatment or prevention of a condition, which is administered before and / or during and / or after treatment with at least one other pharmacologically active substance It was solved by doing.

  In a further aspect of the present invention, the object of the present invention is surprisingly the use of the compounds according to the invention according to the above aspects, preferred embodiments and uses, physiological and / or pathophysiological in mammals. Solved by providing for use in the manufacture of a medicament for the treatment or prevention of a condition, which is administered before and / or during and / or after a treatment such as radiation therapy and / or surgery .

  The compounds according to the invention can be administered in combination therapy, as indicated, with any known pharmacologically effective substance within the scope of the invention.

  In a preferred embodiment, the compound according to the invention is composed of other pharmacologically active substances such as “DNA topoisomerase I and / or II inhibitors, DNA intercalators, alkylating agents, microtubule destabilizing agents, hormones” Receptors and / or growth factor receptors-provided for the above use selected from the group consisting of "agonists and / or-antagonists, growth factors and antibodies to the receptors, kinase inhibitors, antimetabolites".

  In a preferred embodiment, the compound according to the invention is composed of other pharmacologically active substances: "asparaginase, bleomycin, carboplatin, carmustine, chlorambucil, cisplatin, cholaspase, cyclophosphamide, cytarabine, dacarbazine, dactino Mycin, daunorubicin, doxorubicin (adriamycin), epirubicin, etoposide, 5-fluorouracil, hexamethylmelamine, hydroxyurea, ifosfamide, irinotecan, leucovorin, lomustine, mechlorethamine, 6-mercaptopurine, mesna, methotrexate, mitomycin C, mitoxantrone Prednisolone, prednisone, procarbazine, raloxifene, streptozocin, tamoxifen, thioguanine, topote Can, vinblastine, vincristine, vindesine, aminoglutethimide, L-asparaginase, azathioprine, 5-azacytidine, cladribine, busulfan, diethylstilbestrol, 2 ', 2'-difluorodeoxycytidine, docetaxel, erythrohydroxynonyladenine, ethynyl Estradiol, 5-fluorodeoxyuridine, 5-fluorodeoxyuridine monophosphate, fludarabine phosphate, fluoxymesterone, flutamide, hydroxyprogesterone caproate, idarubicin, interferon, medroxyprogesterone acetate, megestrol acetate, melphalan, Mititan, paclitaxel, oxaliplatin, pentostatin, N-phosphonoacetyl-L-aspartate (PALA), Ricamycin, semustine, teniposide, testosterone propionate, thiotepa, trimethylmelamine, uridine, vinorelbine, epothilone, gemcitabine, taxotere, BCNU, CCNU, DTIC, 5-fluorouracil, herceptin, avastin, erbitux, sorafenib , Rapamycin, actinomycin D ", provided for use above, selected from the group consisting of:

  Oral administration can be performed, for example, in solid form as a tablet, capsule, gel capsule, dragee, granule or powder, but can also be in the form of a drinkable solution. For oral administration, the novel compounds according to the invention as defined above are used in the known and customarily physiologically acceptable auxiliary and carrier substances such as gum arabic, talc, starch, sugars such as mannitol. , Methylcellulose, lactose, gelatin, surfactants, magnesium stearate, cyclodextrin, aqueous or non-aqueous carrier materials, diluents, dispersants, emulsifiers, lubricants, preservatives and flavoring agents (eg ethereal oils) be able to. The compounds according to the invention may be dispersed in a particulate, eg nanoparticulate composition.

  Parenteral administration can be effected, for example, by intravenous, subcutaneous or intramuscular injection of aqueous or oily sterile solutions, suspensions or emulsions, by implantation or through ointments, creams or suppositories. In some cases, delayed administration can also be performed. The implant may contain inert materials such as biodegradable polymers or synthetic silicones such as silicone rubber. Intravaginal administration can be performed, for example, by a vaginal ring. Intrauterine administration can be performed, for example, by a diaphragm or another suitable intrauterine device. In addition, transdermal administration is effected in particular by formulations and / or suitable agents such as salves.

  The medicament according to the invention is in a suitable dosage form on the skin, externally, as a solution, suspension, emulsion, foam, ointment, paste or salve; on the buccal side via the oral and lingual mucosa , Lingually or sublingually as tablets, pastilles, dragees, lozenges or mouthwashes; via the gastric and intestinal mucosa, enterally, tablets, dragees, capsules, solutions, suspensions Or as an emulsion; via the rectal mucosa, transrectally, as a suppository, rectal capsule or ointment; via the nasal mucosa, nasally, as a nasal drop, ointment or spray; bronchial epithelium and alveolar epithelium Via the lungs or by inhalation, as an aerosol or inhalant; via the conjunctiva, via the conjunctiva, as eye drops, eye drops, ophthalmic tablets, lamellae or eye wash; via the genital mucosa, intravaginally, As spheres, ointments and rinses, in the womb, as uterine pessaries; via the urinary tract, in the ureter, as a rinse, ointment or pill (Arzneistaebchen); into the artery, as an injection in the artery; In, intravenous, as injection or infusion; intradermal, intradermal, as injection or transplantation; subcutaneously, subcutaneously as injection or transplantation; intramuscular, intramuscular, as injection or transplantation; It can be administered intraperitoneally as an injection or infusion.

  The compounds according to the invention can be prolonged in their drug action by suitable measures with regard to practical therapeutic outcomes. This goal can be achieved by chemical and / or herbal routes. Examples for achieving a prolonged action are the use of implants and liposomes, the formation of sparingly soluble salts and complexes or the use of crystal suspensions.

  As already explained above, the novel compounds according to the invention can be combined with other pharmaceutically active agents. Within the scope of combination therapy, the individual effective ingredients can be administered simultaneously or separately and administered by the same route (eg, oral) or by different routes (eg, oral and infusion). Can do. These components can be present or administered in the same or different amounts in a unit dose. Also, as long as it appears appropriate, a prescribed dosing schedule can be used. Thus, a plurality of novel compounds according to the invention can also be combined with one another.

  Administration can be varied over a wide range depending on the type of indication, the severity of the disease, the type of administration, the age, sex, weight and sensitivity of the subject to be treated. Defining the “pharmacologically effective amount” of the combined pharmaceutical composition corresponds to the ability of one skilled in the art. Administration can be performed alone or in multiple separate administrations.

  Suitable unit doses are from 0.001 mg to 100 mg of agent, ie at least one compound according to the invention, and optionally other pharmaceutically active agents per kg patient body weight.

  In a further aspect of the invention, therefore, at least one compound according to the invention, preferably compounds 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84 pharmacologically effective amounts and , Optionally a pharmaceutical composition comprising a pharmaceutically acceptable carrier substance and / or auxiliary substance It is also included in the present invention.

  Preferred and particularly preferred pharmaceutical compositions comprise at least one of the above-mentioned preferred compounds according to the invention, in which the pharmaceutical composition according to the invention comprises at least one compound according to the invention as defined above. In addition, there may also be at least one other pharmaceutically effective agent already detailed above.

  In a pharmaceutical composition according to the invention, at least one novel compound according to the invention as defined above is present in a pharmacologically effective amount, advantageously in a unit dose, for example in the unit doses described above. And advantageously present in a dosage form allowing oral administration.

  Regarding the pharmaceutical compositions comprising the compounds according to the invention and the use of the compounds according to the invention as pharmaceuticals, it is pointed out that the methods of use and administration have already been mentioned in connection with the use of the new compounds according to the invention themselves. .

  In a further aspect of the invention, the subject of the invention is surprisingly the fact that at least one pharmacologically effective amount of the above-mentioned preferred compounds according to the invention and other drugs as defined above. This has been solved by providing a kit comprising at least one pharmacologically effective amount of a physically effective agent.

General Synthetic Method for Compounds According to the Present Invention A method for producing a substituted pyrido [2,3-b] pyrazine according to the present invention is described below.

  The compounds according to the invention are obtained according to the following schemes (Schemes 1 to 9) or according to methods known to the corresponding person skilled in the art.

  The groups R1 to R36 listed in the following scheme are in their meaning the substituents defined above in relation to the general formulas (I) and (II), such as the Z, R, X, T groups etc. It corresponds to. Each adaptation should be easy for those skilled in the art based on their average knowledge.

Scheme 1

  Precursors for selected examples of pyrido [2,3-b] pyrazine according to the present invention in which the substituents R2 and R4 are to be replaced by hydrogen can be obtained, for example, according to the method in Scheme 2 or correspondingly. It can be obtained according to methods known to the traders.

Scheme 2

  Precursors for selected examples of pyrido [2,3-b] pyrazine according to the present invention where the substituents R3 and / or R4 should be OR31, SR32, NR33R34 can be obtained, for example, according to the method in Scheme 3 or It is obtained according to methods known to those skilled in the art.

Scheme 3

  For precursor 11 described above, intermediate product 22 from Scheme 6 or intermediate products 20, 21, 21a and 21b from Scheme 5 can be used.

  Precursors for selected examples of pyrido [2,3-b] pyrazine according to the invention, which should be the substituent R9 ≠ H, can be prepared, for example, according to the method in scheme 4 or corresponding methods known to those skilled in the art. Obtained according to

Scheme 4

  Conversion of precursors 4, 7, 9 and 15 from Schemes 1-4 to substituted pyrido [2,3-b] pyrazines according to the present invention can be accomplished, for example, according to the method in Scheme 5 or a corresponding person skilled in the art. Can be carried out according to known methods.

Scheme 5

Scheme 5

  Selection of pyrido [2,3-b] pyrazine according to the present invention which may be a substituted aryl group, heteroaryl group, alkyl group, alkenyl group or alkynyl group in which the substituents R3 and / or R4 are selected Examples which can be obtained are obtained, for example, according to the method in scheme 6 or according to methods known to those skilled in the art.

Scheme 6

The present invention according to pyrido [2,3-b] substituent R3 and a pyrazine / or R4 is -N-C (O) -, - N-SO 2 -, - N-C (O) -O- and The precursors for selected examples, which may be —N—C (O) —N—, are obtained, for example, according to the method in Scheme 7 or according to methods known to those skilled in the art.

Scheme 7

  Selected examples of pyrido [2,3-b] pyrazine according to the invention, which may be substituted with urea, carbamate or carbonate, wherein the substituents R3 and / or R4 are selected are for example Scheme 8 Or according to methods known to those skilled in the art.

Scheme 8

  Precursors for selected examples of pyrido [2,3-b] pyrazine according to the present invention, which may be O, S, N-substituted groups in which the substituents R3 and / or R4 are selected are: It can be obtained, for example, according to the method in Scheme 9 or according to methods known to the skilled person.

Scheme 9

  These starting compounds and intermediates are commercially available or can be prepared according to methods known per se or known to those skilled in the art. Starting materials 4, 7, 9-15, 22, 26, 31, 34 and 37 are intermediate compounds useful for the preparation of pyridopyrazine according to the invention.

For the preparation of the starting compounds, intermediate compounds and pyridopyrazine according to the invention, the patent documents WO 2004/104002 and WO 2004/104003, among others, for example, the following most important documents are pointed out, the contents of which are hereby incorporated by reference: Should be part of:

General process for the preparation of the compounds according to the invention Scheme 1: First step 2,6-diamino-3-nitropyridine or 2-amino-3,5-dinitropyridine is reacted with a suitable inert solvent, for example methanol Dissolve in ethanol, dimethylformamide or dioxane. After converting a catalyst, such as Raney nickel, palladium on carbon or platinum (IV) dioxide, the reaction mixture is placed under a hydrogen atmosphere. In that case, the pressure is adjusted to 1-5 bar. The reaction mixture is reacted in the temperature range of 20 ° C. to 60 ° C. for a plurality of hours, for example 1 to 16 hours. After the conversion is complete, the insoluble residue is filtered off, in which case the filtration medium may consist, for example, of silica gel, celite or customary glass fiber filters and is subsequently washed with a corresponding solvent. The crude product is present in solution and is used without further purification for subsequent conversion.

Second Step The 1,2-dione derivative is charged into a suitable inert solvent such as methanol, ethanol, dioxane, toluene or dimethylformamide. 2,3,6-triaminopyridine or 2,3,5-triaminopyridine was charged as a solution of the crude product in one of the above-mentioned solvents immediately after the reduction. To the dione, an acid such as acetic acid or a base such as potassium hydroxide is optionally added. The reaction mixture is reacted at a temperature range of 20 ° C. to 80 ° C. for several hours, for example 20 minutes to 40 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium can consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. In using dimethylformamide, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is extracted with a suitable organic solvent, such as dichloromethane or methyl acetate, The organic phase is then concentrated in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as dioxane, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 2: First Step The pyridopyrazinone derivative 8 is charged in a suitable inert solvent such as dimethylformamide, dioxane or toluene or without solvent. A chlorinating agent such as phosphoryl chloride or thionyl chloride is added at room temperature and the reaction mixture is allowed to react at a temperature range of 20 ° C. to 100 ° C. for several hours, for example 1 hour to 24 hours. After the reaction is complete, the reaction mixture is poured into water and neutralized with a suitable aqueous base such as caustic soda solution. If necessary, the precipitated precipitate is filtered off, in which case the filtration medium may consist, for example, of conventional filter paper, which is subsequently washed with a suitable solvent and the remaining solid is dried in vacuo or water. The phase is extracted with a suitable organic solvent, such as dichloromethane or methyl acetate, and the organic phase is concentrated in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as dioxane or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 3: First Step 2,3,6-triaminopyridine or 2,3,5-triaminopyridine is charged immediately after the reduction as a solution of the crude product in the above solvent. After adding an oxalic acid derivative, such as oxalic acid diethyl ester or oxalyl chloride, the reaction mixture is allowed to reach a temperature range of 20 ° C. to 150 ° C. for several hours, optionally with an acid such as hydrochloric acid, sulfuric acid or acetic acid, For example, the reaction is performed for 10 minutes to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium can consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous base, such as caustic soda solution, followed by a suitable organic solvent, Extract with, for example, dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as dioxane or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Second Step The dione derivative 10 is charged in a suitable inert solvent such as dimethylformamide, dioxane or toluene or without solvent. A chlorinating agent such as phosphoryl chloride or thionyl chloride is added at room temperature and the reaction mixture is allowed to react at a temperature range of 20 ° C. to 100 ° C. for several hours, for example 1 hour to 24 hours. After the reaction is complete, the reaction mixture is poured into water and neutralized with a suitable aqueous base such as caustic soda solution. If necessary, the precipitated precipitate is filtered off, in which case the filtration medium may consist, for example, of conventional filter paper, which is subsequently washed with a suitable solvent and the remaining solid is dried in vacuo or water. The phase is extracted with a suitable organic solvent, such as dichloromethane or methyl acetate, and the organic phase is concentrated in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as dioxane or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Third Step Intermediate 11 is a suitable inert solvent with the corresponding alcohol, thiol or amine and optionally a suitable base, preferably sodium hydride, pyridine, triethylamine, potassium carbonate or sodium methanolate in methanol. For example, in dimethylformamide, dimethyl sulfoxide, methanol, toluene or in a base as a solvent such as pyridine or triethylamine or without solvent. The reaction mixture is reacted in the temperature range of 20 ° C. to 140 ° C. for several hours, for example 30 minutes to 2 days. Optionally, intermediate 11 is combined with a corresponding amine and a suitable catalyst such as tris (dibenzylideneacetone) dipalladium (0) or tetrakis (triphenylphosphine) palladium (0) and a suitable ligand such as 2- The reaction can be carried out using (dicyclohexylphosphanyl) biphenyl and a suitable base such as sodium tert-butanolate in a suitable solvent such as toluene or dimethylformamide. The reaction mixture is reacted in the temperature range of 60 ° C. to 120 ° C. for several hours, for example 2 hours to 30 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium can consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent such as dioxane, ethyl acetate or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 4: First Step Intermediates 4 and 7 are combined with the corresponding suitable chloride, bromide or tosylate and optionally a suitable base, preferably sodium methano in sodium hydride, pyridine, triethylamine, potassium carbonate or methanol. The reaction can be carried out in a suitable inert solvent such as dimethylformamide, dimethyl sulfoxide, methanol, or in a base as a solvent such as pyridine or triethylamine, or without solvent. The reaction mixture is reacted in the temperature range of 20 ° C. to 150 ° C. for several hours, for example 1 to 24 hours. Optionally, intermediates 4 and 7 are substituted with the corresponding aryl bromide or aryl iodide and a suitable catalyst such as palladium acetate or Pd ₂ (dba) ₃ and a suitable ligand such as BINAP and a suitable base such as The reaction can be carried out using potassium carbonate or sodium-t-butanolate in a suitable solvent such as toluene or dioxane. The reaction mixture is reacted in the temperature range of 60 ° C. to 120 ° C. for several hours, for example 10 hours to 30 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Or the reaction mixture is freed from the solvent in vacuum, or any catalyst residues present are filtered off and subsequently washed with the corresponding solvent, and the solvent is removed in vacuo or the reaction Remove the solvent in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 5: First Step Following the basic method, in a subsequent reaction, the product obtained by the basic method can be converted in a manner known to those skilled in the art to obtain the final product according to the invention.

  Here, if the product is to be a derivative of compound 16 according to scheme 5, the reaction product 4, 7, 9 or 15 is converted to the corresponding isocyanate and optionally a suitable base, preferably sodium hydride, potassium. Hexamethyldisilazide, pyridine, triethylamine or potassium carbonate and a suitable inert solvent such as dimethylformamide, dimethyl sulfoxide, acetonitrile, dichloromethane, 1,2-dichloroethane or dioxane, or a base as solvent such as pyridine or The reaction can be carried out in triethylamine or without solvent. The reaction mixture is reacted in the temperature range of 0 ° C. to 80 ° C. for a plurality of hours, for example 1-24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Alternatively, if the product is to be a derivative of compound 17 according to scheme 5, the reaction product 4, 7, 9 or 15 is reacted with phosgene or carbonyldiimidazole and the corresponding amine with a suitable inert The reaction can be carried out in a solvent such as dimethylformamide, tetrahydrofuran, toluene, dichloromethane or acetonitrile. In some cases, a suitable base is used, preferably pyridine, sodium bicarbonate, triethylamine, N-methyl-morpholine or sodium acetate. The reaction mixture is reacted in the temperature range of 0 ° C. to 60 ° C. for several hours, for example 15 minutes to 24 hours. Optionally, the reaction product 4, 7, 9 or 15 is reacted with a corresponding amine-phenyl-carbamate reagent and optionally a suitable base, preferably pyridine, sodium carbonate, triethylamine or sodium hydride, with a suitable inertness. The reaction can be carried out in a solvent such as tetrahydrofuran, dioxane, dichloromethane, dimethylformamide or acetonitrile, or in a base as a solvent such as pyridine or triethylamine, or without solvent. The reaction mixture is reacted in the temperature range of 0 ° C. to 120 ° C. for several hours, for example 1 hour to 18 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Here, if the product is to be a derivative of compound 18 according to scheme 5, the reaction product 4, 7, 9 or 15 is converted to the corresponding isothiocyanate and optionally a suitable base, preferably sodium hydride, Can be reacted with triethylamine, potassium carbonate or pyridine in a suitable inert solvent such as dimethylformamide, tetrahydrofuran, acetone or toluene, or in a base as a solvent such as pyridine or triethylamine or without solvent. . The reaction mixture is reacted in the temperature range of 0 ° C. to 115 ° C. for several hours, for example 30 minutes to 90 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Alternatively, if the product is to be a derivative of compound 19 according to Scheme 5, the reaction product 4, 7, 9 or 15 is combined with thiophosgene or thiocarbonyldiimidazole and the corresponding amine with a suitable The reaction can be carried out in an active solvent such as dimethylformamide, tetrahydrofuran, toluene, dichloromethane, ethanol or acetonitrile. In some cases, suitable bases are used, preferably pyridine, sodium hydrogen carbonate, potassium carbonate, triethylamine or imidazole. The reaction mixture is allowed to react in the temperature range of −10 ° C. to 80 ° C. for a plurality of hours, for example 1 to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Where the product should be a derivative of compound 20 according to scheme 5, the reaction product 4, 7, 9 or 15 is converted to phosgene or carbonyldiimidazole and the corresponding hydroxyl-amine and a suitable inert solvent. For example, dimethylformamide, tetrahydrofuran, dioxane, dichloromethane or toluene. In some cases, a suitable base is used, preferably pyridine, sodium carbonate, triethylamine or sodium acetate. The reaction mixture is reacted in the temperature range of 0 ° C. to 100 ° C. for several hours, for example 1 to 24 hours. Optionally, the reaction product 4, 7, 9 or 15 is reacted with the corresponding hydroxylamine-phenyl-carbamate reagent and optionally a suitable base, preferably pyridine, sodium carbonate, triethylamine or sodium acetate, with a suitable inertness. The reaction can be carried out in a solvent such as tetrahydrofuran, dioxane, dichloromethane, dimethylformamide or toluene, or in a base as a solvent such as pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react in the temperature range from room temperature to 100 ° C. for several hours, for example from 1 hour to 18 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Where the product should be a derivative of compound 21 according to scheme 5, the reaction product 4, 7, 9 or 15 is converted to phosgene or carbonyldiimidazole and the corresponding hydrazine and a suitable inert solvent, for example The reaction can be carried out in dioxane, chloroform, toluene or ethanol. In some cases, a suitable base is used, preferably pyridine, sodium carbonate, diisopropylethylamine or sodium acetate. The reaction mixture is reacted in the temperature range of 0 ° C. to 100 ° C. for several hours, for example 1 to 24 hours. Optionally, the reaction product 4, 7, 9 or 15 is mixed with the corresponding hydrazine-phenyl-carbamate reagent and optionally a suitable base, preferably pyridine, sodium carbonate, triethylamine or sodium acetate and a suitable inert solvent. For example, in tetrahydrofuran, dioxane, dichloromethane, dimethylformamide or toluene, or in a base as a solvent, such as pyridine or triethylamine, or without solvent. The reaction mixture is reacted in the temperature range of 0 ° C. to 100 ° C. for several hours, for example 1 hour to 15 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Alternatively, if the product is to be a derivative of compound 21a according to scheme 5, the reaction product 4, 7, 9 or 15 is combined with oxalyl chloride and the corresponding alcohol, optionally a suitable base, Can be reacted with pyridine, sodium hydroxide, triethylamine in a suitable inert solvent such as tetrahydrofuran, toluene, dichloromethane, ethanol, or a base such as pyridine or triethylamine as a solvent. The reaction mixture is reacted in the temperature range of −10 ° C. to 60 ° C. for several hours, for example 15 minutes to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Or, optionally, if the product should be a derivative of compound 21b according to Scheme 5, the reaction product 4, 7, 9 or 15 is optionally suitable with oxalyl chloride or ethyl oxalyl chloride and the corresponding amine. Can be reacted with a suitable base, preferably pyridine, sodium hydroxide, triethylamine, in a suitable inert solvent such as tetrahydrofuran, toluene, dichloromethane, ethanol or as a solvent such as pyridine or triethylamine. The reaction mixture is reacted in the temperature range of −10 ° C. to 60 ° C. for several hours, for example 15 minutes to 24 hours. Optionally, intermediate 21a is used in the corresponding amine, optionally in a suitable base, preferably pyridine, sodium hydride or triethylamine, in a suitable inert solvent such as tetrahydrofuran, toluene, dichloromethane, ethanol, or The reaction can be carried out in a base as a solvent, for example pyridine or triethylamine. The reaction mixture is allowed to react in the temperature range of 10 to 120 ° C. for several hours, for example 1 to 50 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 6: First Step Following the basic method, in a subsequent reaction, the product obtained by the basic method can be converted in a manner known to those skilled in the art to obtain the final product according to the invention.

Where the product should be compound 23 according to Scheme 6, the reaction product 24 is converted to the corresponding aryl / heteroaryl-boronic acid derivative or aryl / heteroaryl-organotin-compound and a suitable catalyst, For example Pd (PPh ₃ ) ₄ , [1,1′-bis (diphenylphosphino) ferrocene] dichloro-palladium (II) or Pd ₂ (dba) ₃ and a suitable base such as sodium carbonate, cesium carbonate or triethylamine; The reaction can be carried out in a suitable solvent such as dimethylformamide, dimethylformamide / water, toluene, acetonitrile, dimethoxyethane or dioxane. The reaction mixture is reacted in the temperature range of 60 ° C. to 120 ° C. for several hours, for example 6 hours to multiple days. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Or the reaction mixture is freed from the solvent in vacuum, or any catalyst residues present are filtered off and subsequently washed with the corresponding solvent, and the solvent is removed in vacuo or the reaction Remove the solvent in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Here, if the product should be the compound 23a according to Scheme 6, the reaction product 22 is converted to the corresponding aryl-zinc-halide and a suitable catalyst such as Pd (PPh ₃ ) ₄ , [1,1 It can be reacted with '-bis (diphenylphosphino) ferrocene] dichloro-palladium (II) or PdCl ₂ (PPh ₃ ) ₂ in a suitable solvent such as dimethylformamide, tetrahydrofuran, toluene, dimethoxyethane or dioxane. The reaction mixture is allowed to react in the temperature range of room temperature to 120 ° C. for several hours, for example 30 minutes to 48 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Or the reaction mixture is freed from the solvent in vacuum, or any catalyst residues present are filtered off and subsequently washed with the corresponding solvent, and the solvent is removed in vacuo or the reaction Remove the solvent in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off or the aqueous phase is extracted with a suitable organic solvent such as dichloromethane or methyl acetate and the organic phase is extracted. Concentrate in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Here, if the product is to be the compound 24 according to scheme 6, the reaction product 22 is converted to the corresponding vinyl-boronic acid derivative, vinyl-organotin compound or alkene derivative and a suitable catalyst such as Pd (PPh ₃ ) ₄ , [1,1′-bis (diphenylphosphino) ferrocene] dichloro-palladium (II) or Pd (OAc) ₂ and a suitable ligand, such as triphenylphosphine or tri-o-tolylphosphine, and It can be reacted with a suitable base such as potassium carbonate, sodium carbonate, triethylamine or sodium acetate in a suitable solvent such as toluene, dimethylformamide, dimethylformamide / water, acetonitrile, dimethoxyethane or dimethylacetamide. The reaction mixture is reacted in the temperature range of 60 ° C. to 140 ° C. for several hours, for example 3 hours to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Or the reaction mixture is freed from the solvent in vacuum, or any catalyst residues present are filtered off and subsequently washed with the corresponding solvent, and the solvent is removed in vacuo or the reaction Remove the solvent in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Here, if the product is to be a derivative of compound 25 according to Scheme 6, the reaction product 22 is converted to the corresponding alkyne derivative and a suitable catalyst such as Pd (PPh ₃ ) ₄ , PdCl ₂ (PPh ₃ ). ₂ or Pd ₂ (dba) ₃ , suitable additives such as copper (I) iodide, suitable bases such as potassium carbonate, triethylamine or potassium acetate, and suitable solvents such as dimethylformamide, tetrahydrofuran, tetrahydrofuran / The reaction can be carried out in water, toluene or dimethylacetamide. The reaction mixture is allowed to react in the temperature range of room temperature to 120 ° C. for several hours, for example 1 hour to several days. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Or the reaction mixture is freed from the solvent in vacuum, or any catalyst residues present are filtered off and subsequently washed with the corresponding solvent, and the solvent is removed in vacuo or the reaction Remove the solvent in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 7: First Step Following the basic method, in a subsequent reaction, the product obtained by the basic method can be converted in a manner known to those skilled in the art to obtain the final product according to the invention.

Intermediate 22 is a suitable amine and optionally a suitable base, preferably sodium hydride, pyridine, triethylamine, potassium carbonate or sodium methanolate in methanol, in a suitable inert solvent such as dimethylformamide, dimethyl sulfoxide. The reaction can be carried out in methanol, toluene or in a base as solvent, such as pyridine or triethylamine, or without solvent. The reaction mixture is reacted in the temperature range of 20 ° C. to 140 ° C. for several hours, for example 1 hour to several days. Optionally, intermediate 22 is selected from the corresponding amine and a suitable catalyst such as palladium acetate or Pd ₂ (dba) ₃ and a suitable ligand such as BINAP and a suitable base such as potassium carbonate or sodium t-butanolate. Can be reacted in a suitable solvent such as toluene or dioxane. The reaction mixture is reacted in the temperature range of 60 ° C. to 120 ° C. for several hours, for example 10 hours to 30 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Or the reaction mixture is freed from the solvent in vacuum, or any catalyst residues present are filtered off and subsequently washed with the corresponding solvent, and the solvent is removed in vacuo or the reaction Remove the solvent in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent such as dioxane, ethyl acetate or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Second Step Here, if the product is to be a derivative of compound 27 according to scheme 7, the reaction product 26 is prepared, for example, with the corresponding carbonate and optionally a suitable base, preferably sodium hydride, water. Potassium oxide, pyridine, triethylamine or potassium carbonate and optionally a catalyst such as dimethylaminopyridine and a suitable inert solvent such as tetrahydrofuran, toluene, acetonitrile, dichloromethane, acetone or dioxane, or a base as a solvent such as pyridine Alternatively, the reaction can be carried out in triethylamine or without using a solvent. The reaction mixture is reacted in the temperature range of 0 ° C. to 110 ° C. for several hours, for example 30 minutes to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium can consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Here, if the product is to be a derivative of compound 28 according to scheme 7, the reaction product 26 is converted to the corresponding sulfonic acid chloride and optionally a suitable base, preferably sodium hydride, potassium hydroxide, In pyridine, triethylamine or potassium carbonate and optionally a catalyst such as dimethylaminopyridine and a suitable inert solvent such as tetrahydrofuran, toluene, acetonitrile, dichloromethane, acetone, dimethylformamide or dioxane or as a solvent a base such as pyridine Alternatively, the reaction can be carried out in triethylamine or without using a solvent. The reaction mixture is reacted in the temperature range of 0 ° C. to 120 ° C. for several hours, for example 30 minutes to 16 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Here, if the product is to be a derivative of compound 29 according to scheme 7, the reaction product 26 is converted to the corresponding chlorocarbonate and optionally a suitable base, preferably sodium hydride, sodium hydroxide, pyridine. In a suitable inert solvent such as dioxane, tetrahydrofuran, dichloromethane, acetone, dimethylformamide or dichloroethane, or in a base as solvent, such as pyridine or triethylamine, triethylamine or potassium carbonate and optionally a catalyst such as dimethylaminopyridine. Or without using a solvent. The reaction mixture is reacted in the temperature range of −10 ° C. to 100 ° C. for several hours, for example 1 to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Here, if the product is to be a derivative of compound 30 according to scheme 7, the reaction product 26 is converted to the corresponding isocyanate or carbamic acid chloride and optionally a suitable base, preferably sodium hydride, pyridine, In triethylamine, piperidine or potassium carbonate and optionally a catalyst such as dimethylaminopyridine and a suitable inert solvent such as dioxane, tetrahydrofuran, dimethylformamide, toluene or acetonitrile, or in a base as a solvent such as pyridine or triethylamine. Alternatively, the reaction can be performed without using a solvent. The reaction mixture is allowed to react in the temperature range from room temperature to 100 ° C. for several hours, for example 2 hours to 40 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 8: First Step Subsequent to the basic method, in a subsequent reaction, the product obtained by the basic method can be converted in a manner known to those skilled in the art to obtain the final product according to the invention.

  Here, if the product is to be a derivative of compound 32 or 35 according to scheme 8, the reaction product 31 or 34 is converted to the corresponding chlorocarbonate and optionally a suitable base, preferably sodium hydride, water Sodium oxide, pyridine, triethylamine or potassium carbonate and optionally a catalyst such as dimethylaminopyridine and a suitable inert solvent such as dioxane, tetrahydrofuran, dichloromethane, acetone, dimethylformamide or dichloroethane, or a base as solvent, such as The reaction can be carried out in pyridine or triethylamine or without solvent. The reaction mixture is reacted in the temperature range of −10 ° C. to 100 ° C. for several hours, for example 1 to 24 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

  Here, if the product is to be a derivative of compound 33 or 36 according to scheme 8, the reaction product 31 or 34 is converted to the corresponding isocyanate or carbamic acid chloride and optionally a suitable base, preferably hydrogenation. Sodium, pyridine, triethylamine, piperidine or potassium carbonate and optionally a catalyst such as dimethylaminopyridine and a suitable inert solvent such as dioxane, tetrahydrofuran, dimethylformamide, toluene or acetonitrile, or a base as a solvent such as pyridine Alternatively, the reaction can be carried out in triethylamine or without using a solvent. The reaction mixture is allowed to react in the temperature range from room temperature to 100 ° C. for several hours, for example 2 hours to 40 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent, such as ethanol or ethyl acetate, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Scheme 8: First Step Subsequent to the basic method, in a subsequent reaction, the product obtained by the basic method can be converted in a manner known to those skilled in the art to obtain the final product according to the invention.

  Here, if the product is to be a derivative of compound 38 according to scheme 9, the reaction product 37 is prepared, for example, with the corresponding chloride, bromide or iodide and optionally a suitable base, preferably sodium hydride, Sodium methanolate in pyridine, triethylamine, potassium carbonate or methanol and in a suitable inert solvent such as dimethylformamide, dimethyl sulfoxide, methanol, dioxane, tetrahydrofuran, toluene, or in a base as a solvent such as pyridine or triethylamine. Alternatively, the reaction can be performed without using a solvent. The reaction mixture is allowed to react in the temperature range of 0 ° C. to 140 ° C. for several hours, for example 30 minutes to 2 days. Optionally, the amino-substituted intermediate 37 can be converted to, for example, the corresponding chloride, bromide or iodide and a suitable catalyst such as tris (dibenzylideneacetone) dipalladium (0) or tetrakis (triphenylphosphine) palladium (0 ) And a suitable ligand such as 2- (dicyclohexylphosphanyl) biphenyl and a suitable base such as sodium tert-butanolate can be reacted in a suitable solvent such as toluene or dimethylformamide. The reaction mixture is reacted in a temperature range of 60 ° C. to 120 ° C. for several hours, for example 2 hours to 30 hours. After the conversion is complete, any precipitate that precipitates out is filtered off, in which case the filtration medium may consist, for example, of customary filter paper, is subsequently washed with a suitable solvent, and the remaining solid is removed in vacuo. Dry or remove the reaction mixture in vacuo. Optionally, the reaction mixture is stirred in a large amount of water and the precipitated precipitate is filtered off, or the aqueous phase is neutralized with a suitable aqueous acid, such as hydrochloric acid, followed by a suitable organic solvent, such as Extract with dichloromethane or ethyl acetate and concentrate the organic phase in vacuo. The remaining crude product is purified by recrystallization from a suitable solvent such as dioxane, ethyl acetate or toluene, or by column or flash chromatography on silica gel or aluminum oxide. As the eluent, for example, a mixture of methanol and dichloromethane is used.

Some under the recited reaction conditions, OH @ - group, SH- group and NH ₂ - group, a possibility is to undesirable side reactions. Therefore, it is preferable to provide a protecting group for the group, or in the case of NH ₂ , replace it with NO ₂ and subsequently cleave the protecting group or reduce NO ₂ . Here, in another form of the above method, in the starting compound, at least one OH group is replaced, for example, with a benzyloxy group, and / or at least one SH group is replaced, for example, with an S-benzyl group, and / or At least one NH ₂ group can be replaced by an NH-benzyl group or a NO ₂ group. Subsequently, at least one, preferably all benzyloxy or NH-benzyl groups are reduced, for example with hydrogen and palladium on carbon, and / or at least one, preferably all S-benzyl groups are reduced. Can be cleaved in ammonia, for example with sodium, and / or at least one, preferably all NO ₂ groups can be reduced to NH ₂ groups, for example with hydrogen and Raney nickel.

Some under the recited reaction conditions, OH @ - group, NH ₂ - group and COOH- groups, potentially, may be undesirable side reactions. Accordingly, starting compounds and intermediates which contain at least one OH group and / or at least one NH ₂ group and / or at least one COOH group are converted into the corresponding carboxylic acid ester derivatives and carboxylic acid amide derivatives. It is preferable to convert. In a variant of said method, starting compounds and intermediates having at least one OH group and / or having at least one NH ₂ group are activated carboxylic acid groups, for example carboxylic acid chlorides. It can be converted to a carboxylic acid ester derivative or a carboxylic acid amide derivative by reaction with a group. In a variant of said process, the starting compounds and intermediates having at least one COOH group are reacted with an activator such as thionyl chloride or carbonyldiimidazole and subsequently reacted with a suitable alcohol or amine. Thus, it can be converted into a carboxylic acid ester derivative or a carboxylic acid amide derivative. Subsequently, at least one, preferably all carboxylic ester groups or carboxylic amide groups in the starting compounds and intermediates are cleaved, for example with diluted aqueous acids or bases, to obtain at least one, All OH groups and / or NH ₂ groups and / or COOH groups can be released.
The nomenclature of the compounds according to the invention, in particular compounds 1 to 85, was made with AutoNom 2000-software (ISIS ™ / Draw 2.5; MDL).

  The invention will be explained in more detail on the basis of the following examples, but is not limited to these examples.

Example I) Preparation of compounds according to the present invention The following compounds according to the present invention were synthesized by a general synthetic method based on the synthesis schemes 1 to 9. Furthermore, the NMR spectroscopic measurement data and mass spectrometry data or melting point are attached.

  The precursors used for the preparation of the compounds according to the invention can be synthesized according to methods known to those skilled in the art unless otherwise specified.

  The chemicals and solvents used were either commercially available or synthesized from common suppliers (Acros, Aldrich, Fluka, Lancaster, Maybridge, Merck, Sigma, TCI, etc.).

Example 1:
1-ethyl-3- (3-phenylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea (compound 1)
Preparation of 1- (3-chloro-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (reaction according to scheme 5)
100 mg of 3-chloro-pyrido [2,3-b] pyrazin-6-yl-amine (0.55 mmol) was charged into 5 ml of pyridine and 44 μL of ethyl isocyanate (0.55 mmol) was added. Added at room temperature. The mixture was stirred at 75 ° C. for 3 hours and then once again a total of 132 μL of ethyl isocyanate (1.65 mmol) was added to the reaction mixture in small portions over 18 hours. The solvent was then removed in vacuo. The resulting solid was purified via column chromatography on silica gel (eluent dichloromethane / methanol). A pale yellow solid was obtained.

Preparation of 1-ethyl-3- (3-phenylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea (reaction according to scheme 6)
98.1 mg of 1- (3-chloro-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (0.39 mmol) and 10.1 mg of copper (I) iodide ( 0.05 mmol) and 193 μl of triethylamine (1.38 mmol) were charged into 2 ml of anhydrous dimethylformamide under nitrogen as protective gas. Subsequently, 29.1 mg of dichloro-bis (triphenylphosphine) -palladium (II) (0.04 mmol) and 54 μL of phenylacetylene (0.49 mmol) are added in succession and the mixture is stirred at room temperature for 16 hours. Stir for hours. For workup, the mixture was diluted with dichloromethane and added into dilute hydrochloric acid. The precipitated solid was separated by suction and the organic phase was washed with dilute hydrochloric acid and distilled water. After phase separation, the organic phase was removed in vacuo. Further workup was performed by column chromatography on silica gel (eluent dichloromethane / methanol mixture). A yellow solid was obtained.

Melting point: 236-238 ° C. (decomposition)

The following examples were synthesized according to Example 1 and general synthetic methods:
Example 2:
1-ethyl-3- (3-thiophen-3-ylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea (compound 2)
Melting point: 239-242 ° C. (decomposition)

Example 3:
1- (3-Cyclopropylethynyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (compound 3)
Melting point: 227-228 ° C. (decomposition)

Example 4:
1- [3- (3-Dimethylamino-prop-1-ynyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea (compound 4)

Example 5:
1- [3-((E) -2-cyclohexyl-vinyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea (compound 5)
Preparation of 1- [3-((E) -2-cyclohexyl-vinyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea (reaction according to scheme 6)
99.6 mg of 1- (3-chloro-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (0.40 mmol) and 73.6 mg of cyclohexylvinylboronic acid (0. 48 mmol), 84.4 mg sodium carbonate (0.80 mmol), 33.4 mg [1,1′-bis (diphenylphosphino) ferrocene] dichloropalladium (II) (0.04 mmol), Charged in 6 ml dimethylformamide / water (1: 1) under nitrogen. The mixture was then heated to 90 ° C. for 6.5 hours. To the reaction mixture was then added distilled water and the resulting precipitate was separated by suction. Further workup was carried out by column chromatography on silica gel (eluent ethyl acetate / heptane mixture). A light brown solid was obtained.

Melting point: 202-204 ° C. (decomposition)

The following examples were synthesized according to Example 5 and general synthetic methods:
Example 6:
1-ethyl-3- [3-((E) -3-methoxy-propenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (compound 6)

Example 7:
1-ethyl-3- {3-[(E) -2- (4-fluoro-phenyl) -vinyl] -pyrido [2,3-b] pyrazin-6-yl} -urea (compound 27)
Melting point: 217-219 ° C

Example 8
Carbonic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester methyl ester (compound 9)
Preparation of 1-ethyl-3- [3- (4-hydroxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (reaction according to scheme 5)
0.50 g of 4- (6-amino-pyrido [2,3-b] pyrazin-3-yl) -phenol (2.10 mmol) was charged into 5.0 ml of pyridine. 183 μL of ethyl isocyanate (2.31 mmol) was added dropwise at room temperature and the mixture was heated to 70-80 ° C. for 2 hours. Then again 183 μL ethyl isocyanate was added and the mixture was heated to 70-80 ° C. for a further 2 hours. After the reaction was completed, the reaction solution was put into ice water and neutralized with 1N hydrochloric acid. The precipitated product was separated off with suction and dried. The product separated by suction was dissolved in ethanol and mixed with 52 mg potassium hydroxide (0.93 mmol) dissolved in water. The mixture was warmed to 40 ° C. over about 1 hour. The reaction solution was then neutralized with 1N hydrochloric acid and the solvent was removed in vacuo. The resulting solid was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A yellow solid was obtained.

Preparation of carbonic acid-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl-methyl ester (reaction according to scheme 8)
100 mg of 1-ethyl-3- [3- (4-hydroxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (0.32 mmol) and 30 μL of chloroformic acid methyl ester ( 0.39 mmol) and 45 μL of triethylamine (0.32 mmol) were charged in 10 ml of anhydrous dioxane and heated to 100 ° C. for 1 hour. After cooling, the precipitated solid was separated off with suction and dried. After recrystallization from ethanol, a pale yellow solid was obtained.

Melting point: 243-245 ° C

The following examples were synthesized according to Example 8 and general synthetic methods:
Example 9:
Carbonic acid-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl- (2-methoxy-ethyl) -ester (Compound 10)
Melting point: 230-232 ° C

Example 10:
Carbonic acid-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl-phenyl-ester (compound 11)

Example 11:
Diethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester (compound 12)

Example 12:
Carbonic acid 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester (Compound 16)

Example 13:
Carbonic acid-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl-ester-isobutyl-ester (compound 17)

Example 14:
Carbonic acid-but-2-ynyl-ester-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl-ester (compound 18)

Example 15:
Dimethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester (compound 19)
Example 15 was prepared using sodium hydride as the base and dimethylformamide as the solvent.

Melting point:> 230 ° C (decomposition)

Example 16:
Carbonic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester 2-methoxy-ethyl ester (compound 32)

Example 17:
Carbonic acid 2-benzyloxy-ethyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester (compound 33)

Example 18:
Carbonic acid 2-benzyloxy-ethyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester (compound 34)
Melting point: 172-174 ° C

Example 19:
Diethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester ester (Compound 67)
Melting point: 220-222 ° C

Example 20:
Diethyl-carbamic acid 2-chloro-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -6-methoxy-phenyl ester (Compound 68)
Melting point: 237-239 ° C

Example 21:
Carbonic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester 2- [2- (2-methoxy-ethoxy) -ethoxy] -Ethyl ester (Compound 69)
Melting point: 166-167 ° C

Example 22:
(E) -3-Phenyl-acrylic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester (compound 13)
(E) Preparation of 3-phenyl-acrylic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 38.9 mg of 1-ethyl- 3- [3- (4-Hydroxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (0.13 mmol) was charged into 3.0 ml of dry pyridine. 17.5 mg dimethylaminopyridine (0.14 mmol) and 22.9 mg trans-cinnamic acid chloride (0.13 mmol) were added at room temperature and the reaction mixture was stirred at room temperature. After 3 hours, 22.9 mg of trans-cinnamic acid chloride (0.13 mmol) was added once more and the mixture was stirred for an additional 3 hours at room temperature. For workup, the mixture was placed in ice water and neutralized with 1N hydrochloric acid. The precipitated precipitate was suctioned off and dried in vacuo. The yellow solid was obtained as product without further purification.

Melting point: 236-238 ° C

Example 23:
Nonadecanoic acid-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl-phenyl-ester (compound 14)
Preparation of nonadecanoic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 50.0 mg of 1-ethyl-3- [3- (4- Hydroxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (0.16 mmol) was charged into 5.0 ml of dry pyridine. 19.7 mg dimethylaminopyridine (0.16 mmol) and 51.2 mg nonadecanoyl chloride (0.16 mmol) were added at room temperature and the reaction mixture was stirred at room temperature for 4 hours. For workup, the reaction mixture was placed in about 200 ml of distilled water. The precipitated precipitate was separated by suction and washed with water. After purification of the crude product by column chromatography on silica gel (eluent dichloromethane / methanol), a white solid was obtained.

Melting point: 147.2 ° C

Example 24:
1- (3-Benzyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (compound 15)
Preparation of 1- (3-benzyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (reaction according to scheme 6)
2.4 ml of a 0.5M solution of benzyltin bromide (1.20 mmol) in THF and 24.7 mg of tetrakis (triphenylphosphine) -palladium (0) (0.02 mmol) were added under nitrogen. Charged into 1 ml dioxane. Subsequently, 102.4 mg of 1- (3-chloro-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (0.41 mmol) and 1 ml of dioxane were added in small portions. The mixture was then heated to 100 ° C. After 7 hours, the reaction mixture was allowed to cool and then ammonium chloride-saturated solution was added. The aqueous phase was extracted several times with dichloromethane and the collected organic phase was washed with saturated sodium chloride solution, dried over sodium sulfate and the solvent removed in vacuo. After purification by column chromatography on silica gel (eluent dichloromethane / methanol), a yellow solid was obtained.

Example 25:
1-methoxy-3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea (compound 7)
Preparation of 3-phenyl-pyrido [2,3-b] pyrazin-6-yl-amine (reaction according to scheme 6)
1.00 g of 3-chloro-pyrido [2,3-b] pyrazin-6-yl-amine (5.54 mmol), 743 mg of phenylboronic acid (6.09 mmol) and 640 mg of tetrakis (triphenyl Phosphine) -palladium (0) (0.55 mmol) and 1.76 g sodium carbonate (16.6 mmol) in 100 ml dimethylformamide / water (1: 1) under nitrogen as protective gas. Charged and stirred at 80 ° C. for 2 hours. After the reaction was complete, the mixture was separated by suction and the filtrate was poured into 800 ml distilled water. The aqueous phase was extracted several times with ethyl acetate. The solvent was removed from the organic phase in vacuo. The resulting solid was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A yellow solid was obtained.

Preparation of 1-methoxy-3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea (reaction according to scheme 5)
100 mg of 3-phenyl-pyrido [2,3-b] pyrazin-6-yl-amine (0.45 mmol) is dissolved in pyridine and 191 mg of p-nitrophenyl-N-methoxy-carbamate (0 .90 mmol). The mixture was heated under reflux for 4 hours. For workup, the pyridine was removed in vacuo and the residue was dispersed in ethyl acetate and distilled water. The phases were separated and the aqueous phase was extracted twice with ethyl acetate. The concentrated organic phase was dried over MgSO ₄ and the solvent was removed in vacuo. The residue was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A light beige solid was isolated.

The following examples were synthesized according to Example 25 and general synthetic methods:
Example 26:
1-allyloxy-3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea (Compound 8)

Example 27:
1- [4- (t-Butyl-dimethyl-silanyloxy) -butyl] -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea (Compound 36)

Example 28:
1- [4- (t-butyl-dimethyl-silanyloxy) -butyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- Urea (Compound 37)

Example 29:
{4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphoric acid diethyl ester (compound 42)

Example 30:
(4- {3- [3- (4-Hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea} -butyl) -phosphoric acid diethyl ester (Compound 44)

Example 31:
1-methoxy-3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (Compound 61)

Example 32:
{2- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -ethyl} -phosphoric acid-diethyl ester (Compound 62)

Example 33:
Ethyl-carbamic acid 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester (compound 38)
Preparation of 1- (4-hydroxy-butyl) -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea 360 mg (0.22 mmol) of 1- [4- (t -Butyl-dimethyl-silanyloxy) -butyl] -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea was dissolved in 20 ml dichloromethane and 2 molar isopropanolic 5 ml of HCl solution was mixed. After stirring for 12 hours at room temperature, the reaction batch was washed with water and dried (Na ₂ SO ₄ ). After removing the solvent in vacuo, a pale yellow solid was obtained.

Preparation of ethyl-carbamic acid 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester 30 mg (0.08 mmol) of 1- (4-hydroxy -Butyl) -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea was dissolved in 5 ml of pyridine and 7.6 μl (0.10 mmol) of ethyl isocyanate was dissolved. Mix and stir at 100 ° C. for 6 hours. The reaction mixture was poured into 200 ml of water and stirred for 15 minutes. The precipitated precipitate was filtered off and dried. A white solid was obtained.

Example 34:
Carbonic acid methyl ester 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester (compound 39)
Preparation of carbonic acid-methyl-ester-4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester 30 mg (0.08 mmol) of 1- (4 -Hydroxy-butyl) -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea was suspended in 2 ml of dichloromethane and 9.3 μl (0.12 mmol) of Chloroformate methyl ester, 23 μl (0.16 mmol) of triethylamine and 1 mg (0.01 mmol) of dimethylaminopyridine were mixed. The solution was stirred at room temperature for 4 hours. The reaction batch was diluted with 50 ml of dichloromethane, washed with water and dried (Na ₂ SO ₄ ). The solvent was removed in vacuo and the residue was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A white solid was isolated.

The following examples were synthesized according to Example 34 and general synthetic methods:
Example 35:
Carbonic acid 2,2-dimethyl- [1,3] dioxolan-4-ylmethyl ester 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester ( Compound 40)

Example 36:
Carbonic acid-2,3-dihydroxy-propyl ester-4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester (Compound 41)
Preparation of carbonic acid-2,3-dihydroxy-propyl ester-4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester 50 mg (0.10 mmol) Of carbonic acid-2,2-dimethyl- [1,3] dioxolan-4-ylmethyl-ester-4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea]- The butyl ester was dissolved in 20 ml dichloromethane, mixed with 17 μl (0.13 mmol) fluorinated ethyl etherate and stirred at room temperature for 4 hours. The solvent was removed in vacuo and the residue was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A white solid was isolated.

Example 37:
{4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphoric acid (Compound 43)
Preparation of {4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphoric acid 60 mg (0.13 mmol) of {4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphoric acid-diethyl ester is dissolved in 5 ml each of dichloromethane and hexamethyldisilazane and 100 mg (0 .66 mmol) bromotrimethylsilane. After stirring at room temperature for 6 hours, the reaction batch was concentrated in vacuo and the residue was stirred with water for 2 hours. A yellow solid was obtained.

The following examples were synthesized according to Example 37 and general synthetic methods:
Example 38:
(4- {3- [3- (4-Hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea} -butyl) -phosphoric acid (Compound 45)

Example 39:
{2- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -ethyl} -phosphate (Compound 63)

Example 40:
N- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalic acid monoamide ethyl ester (Compound 59)
Preparation of N- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalamic acid-ethyl ester (reaction according to scheme 5)
200 mg (0.90 mmol) 3-phenyl-pyrido [2,3-b] pyrazin-6-ylamine is dissolved in 20 ml pyridine and 0.11 ml (0.99 mmol) ethyloxalyl chloride is dissolved. Mixed. After stirring at room temperature for 2 hours, the solution was poured into ice water. The precipitated solid was filtered off and subsequently washed thoroughly with water. A pale yellow solid was obtained.

Example 41:
N-ethyl-N ′-(3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalamide (Compound 60)
Preparation of N-ethyl-N ′-(3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalic acid amide (reaction according to scheme 5)
23 mg (0.07 mmol) N- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalamic acid-ethyl ester was dissolved in 5 ml dry THF and 0.15 ml (0.38 mmol) of 2.0M ethylamine solution in THF was mixed. After stirring for 48 hours at room temperature, the reaction batch was neutralized. The precipitated solid was filtered off and the filtrate was concentrated to dryness in vacuo. The resulting solid was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A pale yellow solid was obtained.

Example 42:
Ethyl-carbamic acid 4- [6- (3-ethyl-1-phenyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester (compound 20)
Preparation of ethyl-carbamic acid-4- [6- (3-ethyl-1-phenyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester (reaction according to scheme 5)
100 mg of 4- (6-phenylamino-pyrido [2,3-b] pyrazin-3-yl) -phenol hydrochloride (0.28 mmol) was charged in 3 ml of pyridine and 65.3 mg of Ethyl isocyanate (0.90 mmol) was added at room temperature. The mixture was stirred at 80 ° C. for 5 hours, then once more 32.0 mg of ethyl isocyanate (0.45 mmol) was added and the mixture was stirred at 80 ° C. for a further 4 hours. The solvent was then removed in vacuo. The resulting solid was purified twice via column chromatography on silica gel (eluent dichloromethane / methanol and n-heptane / acetone). A pale yellow solid was obtained.

Melting point: 147-151 ° C

  For the preparation of 4- (6-phenylamino-pyrido [2,3-b] pyrazin-3-yl) -phenol hydrochloride, see WO 99/17759.

Example 43
{4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid t-butyl ester (Compound 21)
Preparation of {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid t-butyl ester (reaction according to Scheme 6)
83 mg of 1- (3-chloro-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (0.33 mmol) and 120 mg of [4- (4,4,5,5 -Tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] -carbamic acid-t-butyl-ester (0.36 mmol), 106 mg sodium carbonate (1.00 mmol), 19 mg Of tetrakis (triphenylphosphine) palladium (0.02 mmol) was charged into 7 ml of degassed dimethylformamide / water mixture. The mixture was heated to 100 ° C. for 4 hours. The cooled mixture was mixed with water. The precipitated precipitate was filtered off and subsequently washed with water and dichloromethane. A beige solid was obtained.

Melting point: 281-283 ° C

The following examples were synthesized according to Example 43 and general synthetic methods:
Example 44:
{4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid 2-methoxy-ethyl ester (Compound 22)
Melting point: 249-251 ° C

Example 45:
1-ethyl-3- {3- [4- (3-ethyl-urea) -phenyl] -pyrido [2,3-b] pyrazin-6-yl} -urea (compound 23)
Melting point:> 350 ° C (decomposition)

Example 46:
1- {3- [4- (3,3-Dimethyl-urea) -phenyl] -pyrido [2,3-b] pyrazin-6-yl} -3-ethyl-urea (Compound 24)
Melting point:> 350 ° C

Example 47:
1-ethyl-3- {3- [6- (3-ethyl-urea) -pyridin-3-yl] -pyrido [2,3-b] pyrazin-6-yl} -urea (compound 25)

Example 48:
1-ethyl-3- [3- (4-morpholin-4-ylmethyl-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (compound 28)

Example 49
N- {4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -2- (2-methoxy-ethoxy) -acetamide (Compound 30)
Melting point: 212-215 ° C

Example 50:
2-Benzyloxy-N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -acetamide (Compound 35)
Melting point: 254-256 ° C

Example 51:
1-ethyl-3- [3- (3-trimethylsilanyl-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (Compound 46)
Melting point: 224-228 ° C

  In Example 51, dioxane / water was used as a solvent instead of dimethylformamide / water.

Non-commercial boronic acid derivatives were prepared according to the following methods or according to methods known to those skilled in the art:
Preparation of [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] -carbamic acid-2-methoxy-ethyl-ester 107 mg of 4- (4 , 4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenylamine (0.48 mmol) was dissolved in tetrahydrofuran. 96 mg 2-methoxyethyl chloroformate (0.68 mmol) and 79 mg N-methylmorpholine (0.78 mmol) were added at room temperature. The reaction mixture was stirred at room temperature for 1 day, the precipitated precipitate was filtered off and the solvent was removed in vacuo. A yellowish oil was obtained, which was used in the subsequent reaction without further purification.

The following boronic acid derivatives were prepared according to the methods described above or according to methods known to those skilled in the art:
1-ethyl-3- [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] -urea 1,1-dimethyl-3- [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] -urea 1-ethyl-3- [5- (4,4,5,5-tetramethyl -[1,3,2] dioxaborolan-2-yl) -pyridin-2-yl] -urea 2- (2-methoxy-ethoxy) -N- [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] -acetamide 2-benzyloxy-N- [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolane-2 -Yl) -phenyl] -acetamide Example 52:
1-ethyl-3- {3- [2- (4-fluoro-phenyl) -ethyl] -pyrido [2,3-b] pyrazin-6-yl} -urea (Compound 26)
Preparation of 1-ethyl-3- {3- [2- (4-fluoro-phenyl) -ethyl] -pyrido [2,3-b] pyrazin-6-yl} -urea 108 mg of 1-ethyl-3- { 3- [2- (4-Fluoro-phenyl) -vinyl] -pyrido [2,3-b] pyrazin-6-yl} -urea (0.32 mmol) (compound 27) was dissolved in hot ethanol. It was. 112 mg ammonium formate (1.78 mmol) and 110 mg palladium on carbon (10%) were added and the reaction mixture was heated under reflux for 7.5 hours. The catalyst was filtered off from the cooled reaction mixture and the solvent was removed from the mother liquor. The crude product was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A yellow solid was obtained.

Melting point: 207-209 ° C

Example 53:
1-ethyl-3- (3- {4- [2- (2-methoxy-ethoxy) -ethoxy] -phenyl} -pyrido [2,3-b] pyrazin-6-yl) -urea (Compound 29)
Preparation of 1-ethyl-3- (3- {4- [2- (2-methoxy-ethoxy) -ethoxy] -phenyl} -pyrido [2,3-b] pyrazin-6-yl) -urea (Scheme 9 Reaction)
29 mg sodium hydride (0.71 mmol) (60% suspension in mineral oil) was charged into 4 ml of dried dimethylformamide. At 0 ° C., 70 mg of 1-ethyl-3- [3- (4-hydroxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea (0.23 mmol) Was dissolved in dimethylformamide and added. The mixture was stirred at room temperature for 1 hour. Subsequently, 68 mg of 1-bromo-2- (2-ethoxymethoxy) ethane (0.34 mmol) was added at 0 ° C. and the reaction mixture was stirred at room temperature for 17 hours. Then again 22 mg of 1-bromo-2- (2-ethoxymethoxy) ethane (0.12 mmol) was added and the reaction mixture was stirred at 80 ° C. for 2 h. To the cooled reaction mixture, water was added and the aqueous phase was extracted with dichloromethane. After drying the organic phase over sodium sulfate, the solvent was removed and the crude product was purified by column chromatography on silica gel (eluent dichloromethane / methanol). A yellow solid was obtained.

Example 54:
N- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -4-methyl-benzamide (Compound 31)
Preparation of N- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -4-methyl-benzamide (reaction according to Scheme 7)
100 mg of 1- (3-amino-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (0.43 mmol) was charged into 5 ml of dry pyridine and 57 μl of P-Tolyl chloride (0.43 mmol) was added dropwise. The reaction mixture was stirred at 60 ° C. for 2 hours. Then again 29 μl of p-tolyl chloride (0.22 mmol) was added dropwise and the reaction mixture was stirred at 60 ° C. for a further 2 hours. The cooled reaction mixture was poured into ice water, neutralized with 1N HCl, and the solid was separated by suction. The crude product was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A yellowish solid was obtained.

Example 55:
1- [3- (4-Cyclohexyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea (Compound 47)
Preparation of 1- [3- (4-cyclohexyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea (reaction according to scheme 3)
83 mg 1- (3-chloro-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea (0.33 mmol), 99 mg 4-cyclohexylaniline (0.55 mmol), 30 mg Of sodium t-butyrate (0.30 mmol), 29 mg of tris (dibenzylideneacetone) dipalladium (0) (0.03 mmol) and 68 mg of 2- (dicyclohexylphosphanyl) diphenyl (0.19 mmol). In 1.5 ml of dry toluene. The reaction mixture was heated to 100 ° C. (100 watts) in a microwave for 30 minutes under nitrogen. The solvent was removed in vacuo and the crude product was purified by column chromatography over silica gel (eluent dichloromethane / methanol). A yellow solid was obtained.

Melting point: 246-248 ° C

The following examples were synthesized according to Example 55 and general synthetic methods:
Example 56:
1-ethyl-3- [3- (4-methanesulfonyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea (Compound 48)
Melting point: 275-280 ° C

Example 57:
N- {5- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -2-methyl-phenyl} -methanesulfonamide (Compound 49)
Melting point: 247-250 ° C

Example 58:
3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -N-methyl-benzamide (Compound 50)
Melting point: 228-234 ° C

Example 59:
1-ethyl-3- [3- (4-piperidin-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea (Compound 51)
Melting point: 221-224 ° C

Example 60:
1-ethyl-3- [3- (4-thiophen-3-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea (Compound 52)
Melting point: 264-267 ° C

Example 61:
N- {4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -phenyl} -acetamide (Compound 53)

Example 62:
3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -benzoic acid ethyl ester (Compound 54)
Melting point: 252-255 ° C

Example 63:
Carbonic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester hydrochloride (compound 55)
Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester Preparation of hydrochloride 21 mg of carbonic acid 4- [6- ( 3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester (0.05 mmol) (Example 10) was added to 2.5 ml dichloromethane / methanol. Dissolved in (2: 1). 0.02 ml of 5-6N HCl solution in 2-propanol was added and the mixture was stirred at room temperature for 1 day. The solvent was then removed. A yellow solid was obtained.

Melting point: 190-193 ° C

Example 64:
Carbonic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester p-toluenesulfonate (Compound 56)
Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester Preparation of p-toluenesulfonic acid 48 mg of carbonic acid 4- [ 6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester (0.12 mmol) was added to 4 ml dichloromethane and 0.7 ml methanol. I was charged inside. 23 mg p-toluenesulfonic acid monohydrate (0.12 mmol) was dissolved in 2 ml dichloromethane and 0.5 ml methanol and added at room temperature. The reaction mixture was stirred at 0 ° C. for 1 hour and at room temperature for 1 day. The solvent was removed and the residue was recrystallized from dichloromethane / n-heptane. The precipitated product was separated by suction and washed with n-heptane. A yellow solid was obtained.

Melting point: 145-147 ° C

Example 65:
Carbonic acid 4- {6- [3- (4-hydroxy-butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester hydrochloride (Compound 58)
Carbonic acid 4- {6- [3- (4-hydroxy-butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester Preparation of hydrochloride 117 mg of carbonic acid 4- {6- [3- (4- (t-butyl-dimethyl-silanyloxy) -butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester (0.21 mmol) was dissolved in 40 ml of pre-dried dichloromethane. 0.5 ml of 5-6N HCl solution in 2-propanol was added and the reaction mixture was stirred at room temperature for 15 minutes. The organic phase was washed with water, dried over sodium sulfate and concentrated. A yellow solid was obtained.

Melting point: 165-168 ° C

  Carbonic acid 4- {6- [3- (4- (t-butyl-dimethyl-silanyloxy) -butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl For the preparation of esters, see Schemes 5, 6 and 8, general synthetic methods and methods known to those skilled in the art.

Example 66:
2,2-Dimethyl-propanoic acid (2,2-dimethyl-propionyloxymethoxy)-(4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazine -6-yl] -urea} -butyl) -phosphinoyloxymethyl ester (compound 65)
2,2-Dimethyl-propanoic acid (2,2-dimethyl-propionyloxymethoxy)-(4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazine Preparation of -6-yl] -urea} -butyl) -phosphinoyloxymethyl ester 94 mg of 4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] Pyrazin-6-yl] -urea} -butyl) -phosphonic acid (0.20 mmol) was dissolved in 15 ml DMF and 360 μL pivalic acid chloromethyl ester (2.40 mmol) and 30 μL triethylamine (0 .21 mmol) were mixed and stirred at 60 ° C. for 10 hours. The reaction batch was poured with 50 mL of water and extracted three times with ethyl acetate. The concentrated organic phase was dried over MgSO ₄ and the solvent was removed in vacuo. Subsequently, the residue was purified by column chromatography (eluent dichloromethane / methanol). A beige solid was isolated.

II) Biological action of the compounds according to the invention II. 1) Cell-free kinase assay (by ALPHA technology)
The inhibitory action of the compounds according to the invention was tested in enzyme assays for various human serine / threonine kinases, tyrosine kinases and lipid kinases. In this case, recombinant human kinases such as Erk2, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, p38α, p38γ, Jnk1, Jnk2, etc. are partly full-length kinases, partly abbreviated but consisting of at least a functional kinase domain Used as a fragment. A commercially available kinase protein (prokinase, Upstate) was used as a recombinant fusion protein with GST (glutathione-S-transferase) tag or His tag. Depending on the substrate type, various kinase reactions were quantified using suitable ALPHA ™ beads (Perkin Elmer).

Tests In the following, the substrate test in the Erk-assay will be described strictly. Selected test results of the ErK2α-assay, PI3Kα-assay are listed below. For determination of IC ₅₀ values, potential inhibitor substances were investigated at concentrations graded to 10 floating point types from 3.16 nM to 100 μM.

a) Erk2-ALPHA: test substance, 0.625 ng Erk2 (# 14-173, Upstate), 10 μM ATP, 15 nM biotinylated MBP (myelin basic protein) substrate On Optiplate (PerkinElmer) in a volume of 15 μl for 1 hour, 25 mM Tris, 10 mM MgCl ₂ , 0.1% Tween-20, 100 μM NaVO ₄ , pH 7 in 2 mM DTT. Incubated at 5. Subsequently, the kinase reaction was performed with ALPHA-bead mix (10 μg / ml, # 676061 / PerkinElmer) pre-incubated with anti-phosphorylated MBP antibody (320 pM, # 05-429 / Upstate) with 25 mM Tris, Stopped by adding 200 mM NaCl, 100 mM EDTA, and 0.3% BSA and allowed to stand overnight.

b) PI3K-ALPHA (eg, PI3Kα): test substance, 1 ng PI3Kα (# 14-602, Upstate), 100 μM ATP, 20 μM PIP ₂ -substrate (# P4508, Echelon), 384 type Optiplate (PerkinElmer) was incubated for 1 hour in 50 mM Hepes, 50 mM NaCl, 5 mM MgCl ₂ , 0.05% Chaps, 5 mM DTT at pH 7.4. Subsequently, the kinase reaction was ALPHA-bead mix (10 μg / ml, ##) preincubated with 1 nM GST: Grp1-fusion protein (Upstate) and 15 nM biotinylated PIP3 (# C-39B6 / Echelon). 6760603 / Perkin Elmer) was added to stop in 50 mM Hepes, 50 mM NaCl, 50 mM EDTA, and 0.1% BSA and left overnight.

  Fluorescence detection was performed the following morning on a Fusion ™ α-device (Perkin Elmer).

Evaluation

  Calculation of% inhibition values as a function of substance concentration was performed from raw data measured in Fusion ™ α according to the following formula:

Each control was measured 8 times, and each substance sample was measured twice. The 0% control contains no ATP or substrate, and the 100% control contains no test substance. IC ₅₀ values were measured by GraphPad Prism.

The compounds according to the invention showed effective inhibition of Erk, PI3K, p38α and Jnk1 + Jnk2 with IC ₅₀ values up to 88 nM (see Table 1).

TABLE 1 Test results of MAPK and PI3Kα kinase assays (IC50 [μM] at 10 μM or 100 μM ^* ATP)

II. 2) Cell assay: Test for antiproliferative effect (XTT assay)
The principle of this test is that the tetrazolium dye XTT (sodium 3 '-[1- (phenylaminocarbonyl) -3,4-tetrazolium] -bis (4-methoxy-6-nitro) benzenesulfonic acid, Sigma, by mitochondrial dehydrogenase ) To formazan dye. The dye is formed only by metabolically active cells and its photometrically measurable intensity is a quantitative indicator of the presence of viable cells. The reduction in pigment formation upon incubation of cells and substances is used as a parameter for antiproliferative action.

Test Tumor cells (ATCC) were seeded at a defined number of cells (BxPC3 and Hct116 for 5000 cells / well; MDA MB468 for 10,000 cells / well) in type 96 microtiter plates, followed by 37 ° C. in an incubator. Incubate overnight at 5% CO ₂ and 95% air humidity. Test substances were prepared as stock solutions (100 mM) in DMSO. For the determination of EC ₅₀ values, potential inhibitor substances were added to the cells in a serially logarithmic dilution to give a final concentration of 0.28 μM to 50 μM. The cell plates were then incubated for 45 minutes in an incubator at 37 ° C., 5% CO ₂ and 95% air humidity.

  For the detection reaction, the substrate XTT is mixed with PMS (N-methyl dibenzopyrazine methyl sulfate, Sigma) and the cells are given a final concentration of 325 μg XTT / ml and 2.5 μg PMS / ml. Was added as follows. It was then incubated for 3 hours at 37 ° C. and 95% air humidity. Subsequently, the formazan salt formed by cellular dehydrogenase could be quantified by absorption at 490 nm.

Evaluation

The% inhibition values were evaluated from the values for optical density at 490 nm, each measured by the following formula:
Each control was measured 8 times, and each substance sample was measured twice. The 0% control contains no cells, and the 100% control contains no test substance. EC ₅₀ values were measured by GraphPadPrism.

The compounds according to the invention partly showed an effective inhibition of cell proliferation with EC ₅₀ values up to 2.2 μM (see Table 2).

Table 2: Test results of XTT assay (EC ₅₀ [μM])

II. 3) Cell assay: Test for substrate inhibition (Western blotting)
This method allows testimony as to whether the kinase modulator being investigated achieves the desired effect even under conditions in the cell, i.e. in this case the substrate protein downstream of the target kinase is in its phosphorylated state Will be investigated. To that end, cells incubated with the substance were lysed and the total protein was separated on a reducing polyacrylamide gel. Subsequently, the protein was transferred onto a PVDF membrane by Western blotting and the investigated substrate band was visualized by specific antibodies and suitable detection methods. Substrate proteins downstream of the target kinase are detected simultaneously using each specific anti-phosphorylated antibody and simultaneously all antibodies that recognize the total protein of the substrate. These simultaneous measurements are possible with the Duplex technology of ODYSSEY-Imagers (LiCOR). The intensity of all substrate bands is a standard for normalization or quantification of phosphorylation inhibition or activation.

Testing A suitable tumor cell line (eg BxPC3, Hct116 or MDA MB468) in each standard complete medium at a defined cell number (350,000 cells / well for BxPC3 and Hct116) in a 6-well microtiter plate. Seeding was followed by incubation in an incubator at 37 ° C., 5% CO ₂ and 95% air humidity. Subsequently, the cells were further incubated under serum-reduced conditions for an additional 24 hours, i.e. in the respective medium but with only 0.25% serum. Test substances were prepared as stock solutions (10 mM) in DMSO and incubated with cells for 5 hours at final concentrations of 5 μM, 15.8 μM and 50 μM. Thus, cell lysis was performed using 25 mM Tris, 150 mM NaCl, 10 mM Na-pyrophosphate, 2 mM EGTA, 25 mM β-glycerophosphate, 25 mM NaF, 10% glycerol, Performed in 0.75% NP-40 and 100 μM NaVO ₄ -buffer. Protein quantification by BCA (bicinchoninic acid protein assay kit, Sigma) assay separated approximately 20 μg of protein per lane on a Lemmy-polyacrylamide gel and then by semi-dry western blotting at 0.8 mA / cm ² . Transferred onto a PVDF membrane (Millipore) for 1 hour. Subsequently, the membrane was prehybridized for 1 hour in I-Block reagent (Applied Biosystems) and incubated overnight with specific antibodies. For the measurement of Erk-inhibition and PI3K-inhibition, the downstream substrate Rsk1 was divided into total antibody (Rsk # sc-231g C-21, Santa Cruz) and phosphorylated antibody (Phospho-p90RSK (S380) # 9341. , NEB Cell Signaling) and Akt was detected with whole antibody (Akt1 # sc-1618 C-20, Santa Cruz) and phosphorylated antibody (Phospho-Akt (Ser473) # 9271, NEB Cell Signaling). Detected. After washing the membrane, secondary antibody incubations were performed using anti-rabbit IR dye 800 (# 611-732-127, Rockland) for phosphorylated antibodies and anti-goat Alexa Floor 680 (#A for total protein antibodies). -21081, Molecular Probes). After incubation for 30 minutes in the dark at room temperature, hybridization of the detection antibody onto the membrane was detected by scanning in ODYSSEY-Imager (LiCOR).

Evaluation At a concentration of 5-50 μM, the compounds according to the invention show a double inhibition of Erk (MAPK1 / 2) and PI3K (see Table 3), which are both corresponding phosphorylated substrate proteins Rsk1 and Indicated by inhibition of Akt band intensity.

Table 3: Inhibition of cellular substrate phosphorylation (at 50 μM)

Abbreviations Akt from mouse Akt8 retrovirus or protein kinase B (PKB)
Ask1 Apoptosis signal-regulated kinase ATR ataxia-telangiectasia and RadS related ATM Ataxia-telenigenectasia variant Bag1 Bcl-2 related athanagene-1
Bcl-2 B cell leukemia / lymphoma-2 gene DNA-PK DNA-dependent protein kinase Erk extracellular signal-regulated kinase Flt-3 fms-like tyrosine kinase 3
GSK-3 Glycogen synthase kinase-3
hSMG-1 Human ortholog of the product of seven nematode genes-1 JAK-3 Janus kinase 3
JNK c-jun N-terminal kinase MAPK Mitogen-activated protein kinase Mek MAP or Erk kinase mTOR Mammalian target of rapamycin RDGFR Platelet-derived growth factor receptor PI3K phosphoinositol 3-kinase PIKK phosphoinositol 3-kinase related kinase PIP ₂ phosphatidylinositol two Phosphate PIP ₃ Phosphatidylinositol Triphosphate PtdIns Phosphatidylinositol Raf Rapid Accelerated Fibrosarcoma Ras Rat Sarcoma RTK Receptor Tyrosine Kinase SAPK Stress Activated Protein Kinase Ser Serine Syk Spleen Tyrosine Kinase Thr Threonine Tyr Tyrosine VEGFR Receptor

Claims (60)

Formula (I)

[Where:
(A)
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are “substituted aryl”, wherein “substituted aryl” is the same or different from the group consisting of: Substituted with at least one selected substituent:
(A) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-X1, -N (alkyl) ₂ , —NHC (O) -alkyl, —NHC (O) -cycloalkyl, —NHC (O) -heterocyclyl, —NHC (O) -aryl, —NHC (O) -heteroaryl, —NHC (O) -aryl Alkyl, -NHC (O) -heteroarylalkyl, -NHS (O ₂ ) -Alkyl, -NHS (O ₂ ) -Cycloalkyl, -NHS (O ₂ ) -Heterocyclyl, -NHS (O ₂ ) -Aryl, -NHS (O ₂ ) -Heteroaryl, -NHS (O ₂ ) -Arylalkyl, -NHS (O ₂ ) -Heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -O-X2, -OC (O) -alkyl, -OC (O) -cycloalkyl, -OC (O)- Heterocyclyl, -OC (O) -aryl, -OC (O) -heteroaryl, -OC (O) -arylalkyl, -OC (O) -heteroarylalkyl, -OS (O ₂ ) -Alkyl, -OS (O ₂ ) -Cycloalkyl, -OS (O ₂ ) -Heterocyclyl, -OS (O ₂ ) -Aryl, -OS (O ₂ ) -Heteroaryl, -OS (O ₂ ) -Arylalkyl, -OS (O ₂ ) -Heteroarylalkyl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl, -C (O) O-X3, -C (O) NH-X4,- C (O) N (alkyl) ₂ , -C (O) N (cycloalkyl) ₂ , -C (O) N (aryl) ₂ , -C (O) N (heteroaryl) ₂ , -S (O) -alkyl, -S (O) -aryl, -S (O ₂ ) -Alkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) NH-alkyl, -S (O ₂ ) NH-aryl, -S (O ₂ ) NH-heteroaryl, -S (O ₂ ) NH-arylalkyl, S (O ₂ ) O-alkyl, -S (O ₂ ) O-aryl, -S (O ₂ ) O-arylalkyl ";
Wherein X1, X2, X3, X4 are independently selected from the group consisting of “alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl”;
However, the above substituents of the substituent group (a) are further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N _Three , -NH-cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NX5X6, -S- Cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -O-cycloalkyl , -O-cycloalkylalkyl, -O-arylalkyl, -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclyl, -O-heterocyclylalkyl, -O (-X7-O) _p -X8 (p = 1, 2, 3, 4, 5), -OP (O) (OX9) (OX10), -C (O) O-X11, -C (O) NH ₂ , -C (O) NH-X12, -C (O) NX13X14, -S (O ₂ ) -X15, -P (O) (OH) ₂ , -P (O) (OX16) (OX17), -Si (X18) (X19) (X20), -O-Si (X21) (X22) (X23), -O-C (O) -O-X24 , -O-C (O) -NH-X25, -O-C (O) -NX26X27, -NH-C (O) -O-X28, -NH-C (O) -NH-X29, -NH- C (O) -NX30X31, -NX32-C (O) -O-X33, -NX34-C (O) -NH-X35, -NX36-C (O) -NX37X38, -O-S (O ₂ ) -X39, -NH-C (O) -X40, -NX41-C (O) -X42, -C (O) -X43, -OC (O) -X44, -S (O) -X45, -S (O ₂ ) -NHX46, -S (O ₂ ) -NX47X48, -S (O ₂ ) -OX49, -O (-X50-O) _p -H (p = 1, 2, 3, 4, 5) ";
However, in addition, “—N (alkyl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (b);
At that time, X5, X6, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, X18, X19, X20, X21, X22, X23, X24, X25, X26, X27, X28 X29, X30, X31, X32, X33, X34, X35, X36, X37, X38, X39, X40, X41, X42, X43, X44, X45, X46, X47, X48, X49, X50 are independent of each other. "Alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, X13, X14 and / or X26, X27 and / or Or X30, X31 and / or X37, X38 and / or X47, X48 may be taken together to form a "heterocyclyl";
However, when one of the groups Z3 or Z4 is “substituted aryl” substituted by “heterocyclylalkyl”, the other group Z3 or Z4 is not “substituted or unsubstituted aryl”, respectively. ;
In that case, optionally additionally, one of the groups Z3, Z4, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(B) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX51, -NX52X53, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X54, -C (O) O-X55, -C (O) NH-X56, -C (O) NX57X58, -O-X59, -O (-X60-O) _r -H (r = 1, 2, 3, 4, 5), -O (-X61-O) _r -X62 (r = 1, 2, 3, 4, 5), -OC (O) -X63, -OC (O) -O-X64, -OC (O) -NHX65, -O-C (O)- NX66X67, -OP (O) (OX68) (OX69), -OSi (X70) (X71) (X72), -OS (O ₂ ) -X73, -NHC (O) -X74, -NX75C (O) -X76, -NH-C (O) -O-X77, -NH-C (O) -NH-X78, -NH-C (O ) -NX79X80, -NX81-C (O) -O-X82, -NX83-C (O) -NH-X84, -NX85-C (O) -NX86X87, -NHS (O ₂ ) -X88, -NX89S (O ₂ ) -X90, -S-X91, -S (O) -X92, -S (O ₂ ) -X93, -S (O ₂ ) NH-X94, -S (O ₂ ) NX95X96, -S (O ₂ ) O-X97, -P (O) (OX98) (OX99), -Si (X100) (X101) (X102) ";
At that time, X51, X52, X53, X54, X55, X56, X57, X58, X59, X60, X61, X62, X63, X64, X65, X66, X67, X68, X69, X70, X71, X72, X73, X74 X75, X76, X77, X78, X79, X80, X81, X82, X83, X84, X85, X86, X87, X88, X89, X90, X91, X92, X93, X94, X95, X96, X97, X98, X99 , X100, X101, X102 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X57, X58 and / or X66, X67 and / or X79, X80 and / or X86, X87 and / or X95, X96 may be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (b) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX103, -NX104X105, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X106, -C (O) O-X107, -C (O) NH-X108, -C (O) NX109X110, -O-X111, -O (-X112-O) _s -H (s = 1, 2, 3, 4, 5), -O (-X113-O) _s -X114 (s = 1, 2, 3, 4, 5), -OC (O) -X115, -OC (O) -O-X116, -OC (O) -NHX117, -O-C (O)- NX118X119, -OP (O) (OX120) (OX121), -OSi (X122) (X123) (X124), -OS (O ₂ ) -X125, -NHC (O) -X126, -NX127C (O) -X128, -NH-C (O) -O-X129, -NH-C (O) -NH-X130, -NH-C (O ) -NX131X132, -NX133-C (O) -O-X134, -NX135-C (O) -NH-X136, -NX137-C (O) -NX138X139, -NHS (O ₂ ) -X140, -NX141S (O ₂ ) -X142, -S-X143, -S (O) -X144, -S (O ₂ ) -X145, -S (O ₂ ) NH-X146, -S (O ₂ ) NX147X148, -S (O ₂ ) O-X149, -P (O) (OX150) (OX151), -Si (X152) (X153) (X154) ";
At that time, X103, X104, X105, X106, X107, X108, X109, X110, X111, X112, X113, X114, X115, X116, X117, X118, X119, X120, X121, X122, X123, X124, X125, X126 , X127, X128, X129, X130, X131, X132, X133, X134, X135, X136, X137, X138, X139, X140, X141, X142, X143, X144, X145, X146, X147, X148, X149, X150, X151 , X152, X153, X154 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X109, X110 and / or X118, X119 and / or X131, X132 and / or X138, X139 and / or X147, X148 may be taken together to form "heterocyclyl";
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX155, -NX156X157, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X158, -C (O) O-X159, -C (O) NH-X160, -C (O) NX161X162, -O-X163, -O (-X164-O) _t -H (t = 1, 2, 3, 4, 5), -O (-X165-O) _t -X166 (t = 1, 2, 3, 4, 5), -OC (O) -X167, -OC (O) -O-X168, -OC (O) -NHX169, -O-C (O)- NX170X171, -OP (O) (OX172) (OX173), -OSi (X174) (X175) (X176), -OS (O ₂ ) -X177, -NHC (O) -X178, -NX179C (O) -X180, -NH-C (O) -O-X181, -NH-C (O) -NH-X182, -NH-C (O ) -NX183X184, -NX185-C (O) -O-X186, -NX187-C (O) -NH-X188, -NX189-C (O) -NX190X191, -NHS (O ₂ ) -X192, -NX193S (O ₂ ) -X194, -S-X195, -S (O) -X196, -S (O ₂ ) -X197, -S (O ₂ ) NH-X198, -S (O ₂ ) NX199X200, -S (O ₂ ) O-X201, -P (O) (OX202) (OX203), -Si (X204) (X205) (X206) ";
At that time, X155, X156, X157, X158, X159, X160, X161, X162, X163, X164, X165, X166, X167, X168, X169, X170, X171, X172, X173, X174, X175, X176, X177, X178 , X179, X180, X181, X182, X183, X184, X185, X186, X187, X188, X189, X190, X191, X192, X193, X194, X195, X196, X197, X198, X199, X200, X201, X202, X203 , X204, X205, X206 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X161, X162 and / or X170, X171 and / or X183, X184 and / or X190, X191 and / or X199, X200 may be taken together to form a "heterocyclyl";
Or
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are “substituted aryl”, wherein “substituted aryl” is the same or different from the group consisting of: Substituted with at least one selected substituent:
(C) "C ₉ ~ C ₃₀ -Alkyl, -NX207X208, -NH-C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -cycloalkylalkyl, -NHC (O) -heterocyclylalkyl, -NHC (O) -C ₉ ~ C ₃₀ -Alkyl, -NX209C (O) -X210, -NX211C (O) -C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -OX212, -NX213C (O) -OX214, -NHC (O) -NHX215, -NHC (O) -NX216X217, -NX218C (O) -NHX219, -NX220C (O) -NX221X222 , -NHS (O ₂ ) -Cycloalkylalkyl, -NHS (O ₂ ) -Heterocyclylalkyl, -NX223S (O ₂ ) -X224, -O-C ₉ ~ C ₃₀ -Alkyl, -S-cycloalkyl, -S-heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S-cycloalkylalkyl, -S-heterocyclylalkyl, -S-C ₉ ~ C ₃₀ -Alkyl, -OC (O) -cycloalkylalkyl, -OC (O) -heterocyclylalkyl, -OC (O) -C ₉ ~ C ₃₀ -Alkyl, -OS (O ₂ ) -Cycloalkylalkyl, -OS (O ₂ ) -Heterocyclylalkyl, -OS (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -OC (O) -OX225, -OC (O) -NHX226, -OC (O) -NX227X228, -OP (O) (OX229) (OX230), -C (O) -cycloalkyl, -C (O) -heterocyclyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -C (O) -cycloalkylalkyl, -C (O) -heterocyclylalkyl, -C (O)- C ₉ ~ C ₃₀ -Alkyl, -C (O) O-C ₉ ~ C ₃₀ -Alkyl, -C (O) NH-C ₉ ~ C ₃₀ -Alkyl, -C (O) NX231X232, -C (O) NH-OX233, -C (O) NX234-OX235, -C (O) NH-NX236X237, -C (O) NX238-NX239X240, -S (O ) -Cycloalkyl, -S (O) -heterocyclyl, -S (O) -heteroaryl, -S (O) -arylalkyl, -S (O) -heteroarylalkyl, -S (O) -cycloalkylalkyl , -S (O) -heterocyclylalkyl, -S (O) -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Heterocyclylalkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) NH-cycloalkyl, -S (O ₂ ) NH-heterocyclyl, -S (O ₂ ) NH-heteroarylalkyl, -S (O ₂ ) NH-cycloalkylalkyl, -S (O ₂ ) NH-heterocyclylalkyl, -S (O ₂ ) NH-C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) O-cycloalkyl, -S (O ₂ ) O-heterocyclyl, -S (O ₂ ) O-heteroaryl, -S (O ₂ ) O-heteroarylalkyl, -S (O ₂ ) O-cycloalkylalkyl, -S (O ₂ ) O-heterocyclylalkyl, -S (O ₂ ) O-C ₉ ~ C ₃₀ -Alkyl, -P (O) (OH) ₂ , -P (O) (OX241) (OX242), -Si (X243) (X244) (X245), -O-Si (X246) (X247) (X248) ";
In that case, X207, X208, X209, X210, X211, X212, X213, X214, X215, X216, X217, X218, X219, X220, X221, X222, X223, X224, X225, X226, X227, X228, X229, X230 , X231, X232, X233, X234, X235, X236, X237, X238, X239, X240, X241, X242, X243, X244, X245, X246, X247, X248 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, X216, X217 and / or X221, X222 and / or Or X227, X228 and / or X231, X232 and / or X236, X237 and / or X239, X240 may each be taken together to form a "heterocyclyl";
Provided that the substituent "-N (alkyl) ₂ ","-C (O) N (alkyl) ₂ ","-C (O) N (cycloalkyl) ₂ ","-C (O) N (aryl) ₂ ","-C (O) N (heteroaryl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (i);
However, when one of the groups Z3 or Z4 is “substituted aryl” substituted by “heterocyclylalkyl”, the other group Z3 or Z4 is not “substituted or unsubstituted aryl”, respectively. ;
In this case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX249, -NX250X251, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X252, -C (O) O-X253, -C (O) NH-X254, -C (O) NX255X256, -O-X257, -O (-X258-O) _u -H (u = 1, 2, 3, 4, 5), -O (-X259-O) _u -X260 (u = 1, 2, 3, 4, 5), -OC (O) -X261, -OC (O) -O-X262, -OC (O) -NHX263, -O-C (O)- NX264X265, -OP (O) (OX266) (OX267), -OSi (X268) (X269) (X270), -OS (O ₂ ) -X271, -NHC (O) -X272, -NX273C (O) -X274, -NH-C (O) -O-X275, -NH-C (O) -NH-X276, -NH-C (O ) -NX277X278, -NX279-C (O) -O-X280, -NX281-C (O) -NH-X282, -NX283-C (O) -NX284X285, -NHS (O ₂ ) -X286, -NX287S (O ₂ ) -X288, -S-X289, -S (O) -X290, -S (O ₂ ) -X291, -S (O ₂ ) NH-X292, -S (O ₂ ) NX293X294, -S (O ₂ ) O-X295, -P (O) (OX296) (OX297), -Si (X298) (X1299) (X300) ";
At that time, X249, X250, X251, X252, X253, X254, X255, X256, X257, X258, X259, X260, X261, X262, X263, X264, X265, X266, X267, X268, X269, X270, X271, X272 , X273, X274, X275, X276, X277, X278, X279, X280, X281, X282, X283, X284, X285, X286, X287, X288, X289, X290, X291, X292, X293, X294, X295,9729 , X298, X299, X300 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X255, X256 and / or X264, X265 and / or X277, X278 and / or X284, X285 and / or X293, X294 may be taken together to form a “heterocyclyl”;
In that case, optionally, one of the groups Z3, Z3, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(D) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX301, -NX302X303, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X304, -C (O) O-X305, -C (O) NH-X306, -C (O) NX307X308, -O-X309, -O (-X310-O) _uu -H (uu = 1, 2, 3, 4, 5), -O (-X311-O) _uu -X312 (uu = 1, 2, 3, 4, 5), -OC (O) -X313, -OC (O) -O-X314, -OC (O) -NHX315, -O-C (O)- NX316X317, -OP (O) (OX318) (OX319), -OSi (X320) (X321) (X322), -OS (O ₂ ) -X323, -NHC (O) -X324, -NX325C (O) -X326, -NH-C (O) -O-X327, -NH-C (O) -NH-X328, -NH-C (O ) -NX329X330, -NX331-C (O) -O-X332, -NX333-C (O) -NH-X334, -NX335-C (O) -NX336X337, -NHS (O ₂ ) -X338, -NX339S (O ₂ ) -X340, -S-X341, -S (O) -X342, -S (O ₂ ) -X343, -S (O ₂ ) NH-X344, -S (O ₂ ) NX345X346, -S (O ₂ ) O-X347, -P (O) (OX348) (OX349), -Si (X350) (X351) (X352) ";
At that time, X301, X302, X303, X304, X305, X306, X307, X308, X309, X310, X311, X312, X313, X314, X315, X316, X317, X318, X319, X320, X321, X322, X323, X324 , X325, X326, X327, X328, X329, X330, X331, X332, X333, X334, X335, X336, X337, X338, X339, X340, X341, X342, X343, X344, X345, X346, X347, X348, , X350, X351, X352 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X307, X308 and / or X316, X317 and / or X329, X330 and / or X336, X337 and / or X345, X346 may be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (d) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX353, -NX354X355, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X356, -C (O) O-X357, -C (O) NH-X358, -C (O) NX359X360, -O-X361, -O (-X362-O) _v -H (v = 1, 2, 3, 4, 5), -O (-X363-O) _v -X364 (v = 1, 2, 3, 4, 5), -OC (O) -X365, -OC (O) -O-X366, -OC (O) -NHX367, -O-C (O)- NX368X369, -OP (O) (OX370) (OX371), -OSi (X372) (X373) (X374), -OS (O ₂ ) -X375, -NHC (O) -X376, -NX377C (O) -X378, -NH-C (O) -O-X379, -NH-C (O) -NH-X380, -NH-C (O ) -NX381X382, -NX383-C (O) -O-X384, -NX385-C (O) -NH-X386, -NX387-C (O) -NX388X389, -NHS (O ₂ ) -X390, -NX391S (O ₂ ) -X392, -S-X393, -S (O) -X394, -S (O ₂ ) -X395, -S (O ₂ ) NH-X396, -S (O ₂ ) NX397X398, -S (O ₂ ) O-X399, -P (O) (OX400) (OX401), -Si (X402) (X403) (X404) ";
At that time, X353, X354, X355, X356, X357, X358, X359, X360, X361, X362, X363, X364, X365, X366, X367, X368, X369, X370, X371, X372, X373, X375, X376 X377, X378, X379, X380, X381, X382, X383, X384, X385, X386, X387, X388, X389, X390, X391, X392, X393, X394, X395, X396, X397, X398, X399, X398, X399 , X402, X403, and X404 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X359, X360 and / or X368, X369 and / or X381, X382 and / or X388, X389 and / or X397, X398 may be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX405, -NX406X407, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X408, -C (O) O-X409, -C (O) NH-X410, -C (O) NX411X412, -O-X413, -O (-X414-O) _w -H (w = 1, 2, 3, 4, 5), -O (-X415-O) _w -X416 (w = 1, 2, 3, 4, 5), -OC (O) -X417, -OC (O) -O-X418, -OC (O) -NHX419, -O-C (O)- NX420X421, -OP (O) (OX422) (OX423), -OSi (X424) (X425) (X426), -OS (O ₂ ) -X427, -NHC (O) -X428, -NX429C (O) -X430, -NH-C (O) -O-X431, -NH-C (O) -NH-X432, -NH-C (O ) -NX433X434, -NX435-C (O) -O-X436, -NX437-C (O) -NH-X438, -NX439-C (O) -NX440X441, -NHS (O ₂ ) -X442, -NX443S (O ₂ ) -X444, -S-X445, -S (O) -X446, -S (O ₂ ) -X447, -S (O ₂ ) NH-X448, -S (O ₂ ) NX449X450, -S (O ₂ ) O-X451, -P (O) (OX452) (OX453), -Si (X454) (X455) (X456) ";
At that time, X405, X406, X407, X408, X409, X410, X411, X412, X413, X414, X415, X416, X417, X418, X419, X420, X421, X422, X423, X424, X425, X426, X427, X428 , X429, X430, X431, X432, X433, X434, X435, X436, X437, X438, X439, X440, X441, X442, X443, X444, X445, X446, X447, X448, X449, X450, X451, X452, , X454, X455, X456 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X411, X412 and / or X420, X421 and / or X433, X434 and / or X440, X441 and / or X449, X450 can be taken together to form a "heterocyclyl";
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(E) hydrogen;
(F) halogen, F, Cl, Br, I;
(G) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX457, -NX458X459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X460, -C (O) O-X461, -C (O) NH-X462, -C (O) NX463X464, -O-X465, -O (-X466-O) _x -H (x = 1, 2, 3, 4, 5), -O (-X467-O) _x -X468 (x = 1, 2, 3, 4, 5), -OC (O) -X469, -OC (O) -O-X470, -OC (O) -NHX471, -O-C (O)- NX472X473, -OP (O) (OX474) (OX475), -OSi (X476) (X477) (X478), -OS (O ₂ ) -X479, -NHC (O) -X480, -NX481C (O) -X482, -NH-C (O) -O-X483, -NH-C (O) -NH-X484, -NH-C (O ) -NX485X486, -NX487-C (O) -O-X488, -NX489-C (O) -NH-X490, -NX491-C (O) -NX492X493, -NHS (O ₂ ) -X494, -NX495S (O ₂ ) -X496, -S-X497, -S (O) -X498, -S (O ₂ ) -X499, -S (O ₂ ) NH-X500, -S (O ₂ ) NX501X502, -S (O ₂ ) O-X503, -P (O) (OX504) (OX505), -Si (X506) (X507) (X508) ";
At that time, X457, X458, X459, X460, X461, X462, X463, X464, X465, X466, X467, X468, X469, X470, X471, X472, X473, X474, X475, X476, X477, X478, X480 , X481, X482, X483, X484, X485, X486, X487, X488, X489, X490, X491, X492, X493, X494, X495, X496, X497, X498, X499, X500, X501, X502, X503, X504 , X506, X507, X508 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X463, X464 and / or X472, X473 and / or X485, X486 and / or X492, X493 and / or X501, X502 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX509, -NX510X511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X512, -C (O) O-X513, -C (O) NH-X514, -C (O) NX515X516, -O-X517, -O (-X518-O) _y -H (y = 1, 2, 3, 4, 5), -O (-X519-O) _y -X520 (y = 1, 2, 3, 4, 5), -OC (O) -X521, -OC (O) -O-X522, -OC (O) -NHX523, -O-C (O)- NX524X525, -OP (O) (OX526) (OX527), -OSi (X528) (X529) (X530), -OS (O ₂ ) -X531, -NHC (O) -X532, -NX533C (O) -X534, -NH-C (O) -O-X535, -NH-C (O) -NH-X536, -NH-C (O ) -NX537X538, -NX539-C (O) -O-X540, -NX541-C (O) -NH-X542, -NX543-C (O) -NX544X545, -NHS (O ₂ ) -X546, -NX547S (O ₂ ) -X548, -S-X549, -S (O) -X550, -S (O ₂ ) -X551, -S (O ₂ ) NH-X552, -S (O ₂ ) NX553X554, -S (O ₂ ) O-X555, -P (O) (OX556) (OX557), -Si (X558) (X559) (X560) ";
At that time, X509, X510, X511, X512, X513, X514, X515, X516, X517, X518, X519, X520, X521, X522, X523, X524, X525, X526, X527, X528, X529, X530, X531, X532 , X533, X534, X535, X536, X537, X538, X539, X540, X541, X542, X543, X544, X545, X546, X547, X548, X549, X550, X551, X552, X553, X554, X555, X556 , X558, X559, X560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X515, X516 and / or X524, X525 and / or X537, X538 and / or X544, X545 and / or X553, X554 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX561, -NX562X563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X564, -C (O) O-X565, -C (O) NH-X566, -C (O) NX567X568, -O-X569, -O (-X570-O) _z -H (z = 1, 2, 3, 4, 5), -O (-X571-O) _z -X572 (z = 1, 2, 3, 4, 5), -OC (O) -X573, -OC (O) -O-X574, -OC (O) -NHX575, -O-C (O)- NX576X577, -OP (O) (OX578) (OX579), -OSi (X580) (X581) (X582), -OS (O ₂ ) -X583, -NHC (O) -X584, -NX585C (O) -X586, -NH-C (O) -O-X587, -NH-C (O) -NH-X588, -NH-C (O ) -NX589X590, -NX591-C (O) -O-X592, -NX593-C (O) -NH-X594, -NX595-C (O) -NX596X597, -NHS (O ₂ ) -X598, -NX599S (O ₂ ) -X600, -S-X601, -S (O) -X602, -S (O ₂ ) -X603, -S (O ₂ ) NH-X604, -S (O ₂ ) NX605X606, -S (O ₂ ) O-X607, -P (O) (OX608) (OX609), -Si (X610) (X611) (X612) ";
At that time, X561, X562, X563, X564, X565, X566, X567, X568, X569, X570, X571, X572, X573, X574, X575, X576, X577, X578, X579, X580, X581, X582, X583, 584 X585, X586, X587, X588, X589, X590, X591, X592, X593, X594, X595, X596, X597, X598, X599, X600, X601, X602, X603, X604, X605, X606, X607, X608 , X610, X611, X612 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X567, X568 and / or X576, X577 and / or X589, X590 and / or X596, X597 and / or X605, X606 may each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX613, -NX614X615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X616, -C (O) O-X617, -C (O) NH-X618, -C (O) NX619X620, -O-X621, -O (-X622-O) _a -H (a = 1, 2, 3, 4, 5), -O (-X623-O) _a -X624 (a = 1, 2, 3, 4, 5), -OC (O) -X625, -OC (O) -O-X626, -OC (O) -NHX627, -O-C (O)- NX628X629, -OP (O) (OX630) (OX631), -OSi (X632) (X633) (X634), -OS (O ₂ ) -X635, -NHC (O) -X636, -NX637C (O) -X638, -NH-C (O) -O-X639, -NH-C (O) -NH-X640, -NH-C (O ) -NX641X642, -NX643-C (O) -O-X644, -NX645-C (O) -NH-X646, -NX647-C (O) -NX648X649, -NHS (O ₂ ) -X650, -NX651S (O ₂ ) -X652, -S-X653, -S (O) -X654, -S (O ₂ ) -X655, -S (O ₂ ) NH-X656, -S (O ₂ ) NX657X658, -S (O ₂ ) O-X659, -P (O) (OX660) (OX661), -Si (X662) (X663) (X664) ";
At that time, X613, X614, X615, X616, X617, X618, X619, X620, X621, X622, X623, X624, X625, X626, X627, X628, X629, X630, X631, X632, X633, X634, X635, X636 , X637, X638, X639, X640, X641, X642, X643, X644, X645, X646, X647, X648, X649, X650, X651, X652, X653, X654, X655, X656, X657, X658, X659, X660 , X662, X663, X664 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X619, X620 and / or X628, X629 and / or X641, X642 and / or X648, X649 and / or X657, X658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX665, -NX666X667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X668, -C (O) O-X669, -C (O) NH-X670, -C (O) NX671X672, -O-X673, -O (-X674-O) _b -H (b = 1, 2, 3, 4, 5), -O (-X675-O) _b -X676 (b = 1, 2, 3, 4, 5), -OC (O) -X677, -OC (O) -O-X678, -OC (O) -NHX679, -O-C (O)- NX680X681, -OP (O) (OX682) (OX683), -OSi (X684) (X685) (X686), -OS (O ₂ ) -X687, -NHC (O) -X688, -NX689C (O) -X690, -NH-C (O) -O-X691, -NH-C (O) -NH-X692, -NH-C (O ) -NX693X694, -NX695-C (O) -O-X696, -NX697-C (O) -NH-X698, -NX699-C (O) -NX700X701, -NHS (O ₂ ) -X702, -NX703S (O ₂ ) -X704, -S-X705, -S (O) -X706, -S (O ₂ ) -X707, -S (O ₂ ) NH-X708, -S (O ₂ ) NX709X710, -S (O ₂ ) O-X711, -P (O) (OX712) (OX713), -Si (X714) (X715) (X716) ";
At that time, X665, X666, X667, X668, X669, X670, X671, X672, X673, X674, X675, X676, X677, X678, X679, X680, X681, X682, X683, X684, X685, X686, X687, 688 X689, X690, X691, X692, X693, X694, X695, X696, X697, X698, X699, X700, X701, X702, X703, X704, X705, X706, X707, X708, X709, X710, X711, X712 , X714, X715, X716 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X671, X672 and / or X680, X681 and / or X693, X694 and / or X700, X701 and / or X709, X710 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX717, -NX718X719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X720, -C (O) O-X721, -C (O) NH-X722, -C (O) NX723X724, -O-X725, -O (-X726-O) _c -H (c = 1, 2, 3, 4, 5), -O (-X727-O) _c -X728 (c = 1, 2, 3, 4, 5), -OC (O) -X729, -OC (O) -O-X730, -OC (O) -NHX731, -O-C (O)- NX732X733, -OP (O) (OX734) (OX735), -OSi (X736) (X737) (X738), -OS (O ₂ ) -X739, -NHC (O) -X740, -NX741C (O) -X742, -NH-C (O) -O-X743, -NH-C (O) -NH-X744, -NH-C (O ) -NX745X746, -NX747-C (O) -O-X748, -NX749-C (O) -NH-X750, -NX751-C (O) -NX752X753, -NHS (O ₂ ) -X754, -NX755S (O ₂ ) -X756, -S-X757, -S (O) -X758, -S (O ₂ ) -X759, -S (O ₂ ) NH-X760, -S (O ₂ ) NX761X762, -S (O ₂ ) O-X763, -P (O) (OX764) (OX765), -Si (X766) (X767) (X768) ";
At that time, X717, X718, X719, X720, X721, X722, X723, X724, X725, X726, X727, X728, X729, X730, X731, X732, X733, X734, X735, X736, X737, X738, X739, X739 X741, X742, X743, X744, X745, X746, X747, X748, X749, X750, X751, X752, X753, X754, X755, X756, X757, X758, X759, X760, X761, X762, X763, 764 , X766, X767, X768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X723, X724 and / or X732, X733 and / or X745, X746 and / or X752, X753 and / or X761, X762 may each be taken together to form a "heterocyclyl";
(J) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX769, -NX770X771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X772, -C (O) O-X773, -C (O) NH-X774, -C (O) NX775X776, -O-X777, -O (-X778-O). _d -H (d = 1, 2, 3, 4, 5), -O (-X779-O) _d -X780 (d = 1, 2, 3, 4, 5), -OC (O) -X781, -OC (O) -O-X782, -OC (O) -NHX783, -O-C (O)- NX784X785, -OP (O) (OX786) (OX787), -OSi (X788) (X789) (X790), -OS (O ₂ ) -X791, -NHC (O) -X792, -NX793C (O) -X794, -NH-C (O) -O-X795, -NH-C (O) -NH-X796, -NH-C (O ) -NX797X798, -NX799-C (O) -O-X800, -NX801-C (O) -NH-X802, -NX803-C (O) -NX804X805, -NHS (O ₂ ) -X806, -NX807S (O ₂ ) -X808, -S-X809, -S (O) -X810, -S (O ₂ ) -X811, -S (O ₂ ) NH-X812, -S (O ₂ ) NX813X814, -S (O ₂ ) O-X815, -P (O) (OX816) (OX817), -Si (X818) (X819) (X820) ";
At that time, X769, X770, X771, X772, X773, X774, X775, X776, X777, X778, X779, X780, X781, X782, X783, X784, X785, X786, X787, X788, X789, X790, X791, 792 X793, X794, X795, X796, X797, X798, X799, X800, X801, X802, X803, X804, X805, X806, X807, X808, X809, X810, X811, X812, X813, X814, X815, X816 , X818, X819, X820 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X775, X776 and / or X784, X785 and / or X797, X798 and / or X804, X805 and / or X813, X814 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX821, -NX822X823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X824, -C (O) O-X825, -C (O) NH-X826, -C (O) NX827X828, -O-X829, -O (-X830-O) _e -H (e = 1, 2, 3, 4, 5), -O (-X831-O) _e -X832 (e = 1, 2, 3, 4, 5), -OC (O) -X833, -OC (O) -O-X834, -OC (O) -NHX835, -O-C (O)- NX836X837, -OP (O) (OX838) (OX839), -OSi (X840) (X841) (X842), -OS (O ₂ ) -X843, -NHC (O) -X844, -NX845C (O) -X846, -NH-C (O) -O-X847, -NH-C (O) -NH-X848, -NH-C (O ) -NX849X850, -NX851-C (O) -O-X852, -NX853-C (O) -NH-X854, -NX855-C (O) -NX856X857, -NHS (O ₂ ) -X858, -NX859S (O ₂ ) -X860, -S-X861, -S (O) -X862, -S (O ₂ ) -X863, -S (O ₂ ) NH-X864, -S (O ₂ ) NX865X866, -S (O ₂ ) O-X867, -P (O) (OX868) (OX869), -Si (X870) (X871) (X872) ";
At that time, X821, X822, X823, X824, X825, X826, X827, X828, X829, X830, X831, X832, X833, X834, X835, X836, X837, X838, X839, X840, X841, X842, X843, 44 X845, X846, X847, X848, X849, X850, X851, X852, X853, X854, X855, X856, X857, X858, X859, X860, X861, X862, X863, X864, X865, X866, X867, 86 , X870, X871, X872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X827, X828 and / or X836, X837 and / or X849, X850 and / or X856, X857 and / or X865, X866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX873, -NX874X875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X876, -C (O) O-X877, -C (O) NH-X878, -C (O) NX879X880, -O-X881, -O (-X882-O) _f -H (f = 1, 2, 3, 4, 5), -O (-X883-O) _f -X884 (f = 1, 2, 3, 4, 5), -OC (O) -X885, -OC (O) -O-X886, -OC (O) -NHX887, -O-C (O)- NX888X889, -OP (O) (OX890) (OX891), -OSi (X892) (X893) (X894), -OS (O ₂ ) -X895, -NHC (O) -X896, -NX897C (O) -X898, -NH-C (O) -O-X899, -NH-C (O) -NH-X900, -NH-C (O ) -NX901X902, -NX903-C (O) -O-X904, -NX905-C (O) -NH-X906, -NX907-C (O) -NX908X909, -NHS (O ₂ ) -X910, -NX911S (O ₂ ) -X912, -S-X913, -S (O) -X914, -S (O ₂ ) -X915, -S (O ₂ ) NH-X916, -S (O ₂ ) NX917X918, -S (O ₂ ) O-X919, -P (O) (OX920) (OX921), -Si (X922) (X923) (X924) ";
At that time, X873, X874, X875, X876, X877, X878, X879, X880, X881, X882, X883, X884, X885, X886, X887, X888, X889, X890, X891, X892, X893, X894, X895, 96 , X897, X898, X899, X900, X901, X902, X903, X904, X905, X906, X907, X908, X909, X910, X911, X912, X913, X914, X915, X916, X917, X918, X919, X920 , X922, X923, X924 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X879, X880 and / or X888, X889 and / or X901, X902 and / or X908, X909 and / or X917, X918 may each be taken together to form a “heterocyclyl”;
(K) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX925, -NX926X927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X928, -C (O) O-X929, -C (O) NH-X930, -C (O) NX931X932, -O-X933, -O (-X934-O) _g -H (g = 1, 2, 3, 4, 5), -O (-X935-O) _g -X936 (g = 1, 2, 3, 4, 5), -OC (O) -X937, -OC (O) -O-X938, -OC (O) -NHX939, -O-C (O)- NX940X941, -OP (O) (OX942) (OX943), -OSi (X944) (X945) (X946), -OS (O ₂ ) -X947, -NHC (O) -X948, -NX949C (O) -X950, -NH-C (O) -O-X951, -NH-C (O) -NH-X952, -NH-C (O ) -NX953X954, -NX955-C (O) -O-X956, -NX957-C (O) -NH-X958, -NX959-C (O) -NX960X961, -NHS (O ₂ ) -X962, -NX963S (O ₂ ) -X964, -S-X965, -S (O) -X966, -S (O ₂ ) -X967, -S (O ₂ ) NH-X968, -S (O ₂ ) NX969X970, -S (O ₂ ) O-X971, -P (O) (OX972) (OX973), -Si (X974) (X975) (X976) ";
At that time, X925, X926, X927, X928, X929, X930, X931, X932, X933, X934, X935, X936, X937, X938, X939, X940, X941, X942, X943, X944, X945, X946, X947, X948 , X949, X950, X951, X952, X953, X954, X955, X956, X957, X958, X959, X960, X961, X962, X963, X964, X965, X966, X967, X968, X969, X970, X971, X972 , X974, X975, X976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X931, X932 and / or X940, X941 and / or X953, X954 and / or X960, X961 and / or X969, X970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX977, -NX978X979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X980, -C (O) O-X981, -C (O) NH-X982, -C (O) NX983X984, -O-X985, -O (-X986-O) _h -H (h = 1, 2, 3, 4, 5), -O (-X987-O) _h -X988 (h = 1, 2, 3, 4, 5), -OC (O) -X989, -OC (O) -O-X990, -OC (O) -NHX991, -O-C (O)- NX992X993, -OP (O) (OX994) (OX995), -OSi (X996) (X997) (X998), -OS (O ₂ ) -X999, -NHC (O) -X1000, -NX1001C (O) -X1002, -NH-C (O) -O-X1003, -NH-C (O) -NH-X1004, -NH-C (O ) -NX1005X1006, -NX1007-C (O) -O-X1008, -NX1009-C (O) -NH-X1010, -NX1011-C (O) -NX1012X1013, -NHS (O ₂ ) -X1014, -NX1015S (O ₂ ) -X1016, -S-X1017, -S (O) -X1018, -S (O ₂ ) -X1019, -S (O ₂ ) NH-X1020, -S (O ₂ ) NX1021X1022, -S (O ₂ ) O-X1023, -P (O) (OX1024) (OX1025), -Si (X1026) (X1027) (X1028) ";
At that time, X977, X978, X979, X980, X981, X982, X983, X984, X985, X986, X987, X988, X989, X990, X991, X992, X993, X994, X995, X996, X997, X999, 1000 , X1001, X1002, X1003, X1004, X1005, X1006, X1007, X1008, X1009, X1010, X1011, X1012, X1013, X1014, X1015, X1016, X1017, X1018, X1019, X1020, X1021, X1022, X1023, X1024 , X1026, X1027, X1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X983, X984 and / or X992, X993 and / or X1005, X1006 and / or X1012, X1013 and / or X1021, X1022 may each be taken together to form a "heterocyclyl";
(L) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1029, -NX1030X1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1032, -C (O) O-X1033, -C (O) NH-X1034, -C (O) NX1035X1036, -O-X1037, -O (-X1038-O) _i -H (i = 1, 2, 3, 4, 5), -O (-X1039-O) _i -X1040 (i = 1, 2, 3, 4, 5), -OC (O) -X1041, -OC (O) -O-X1042, -OC (O) -NHX1043, -O-C (O)- NX1044X1045, -OP (O) (OX1046) (OX1047), -OSi (X1048) (X1049) (X1050), -OS (O ₂ ) -X1051, -NHC (O) -X1052, -NX1053C (O) -X1054, -NH-C (O) -O-X1055, -NH-C (O) -NH-X1056, -NH-C (O ) -NX1057X1058, -NX1059-C (O) -O-X1060, -NX1061-C (O) -NH-X1062, -NX1063-C (O) -NX1064X1065, -NHS (O ₂ ) -X1066, -NX1067S (O ₂ ) -X1068, -S-X1069, -S (O) -X1070, -S (O ₂ ) -X1071, -S (O ₂ ) NH-X1072, -S (O ₂ ) NX1073X1074, -S (O ₂ ) O-X1075, -P (O) (OX1076) (OX1077), -Si (X1078) (X1079) (X1080) ";
At that time, X1029, X1030, X1031, X1032, X1033, X1034, X1035, X1036, X1037, X1038, X1039, X1040, X1041, X1042, X1043, X1044, X1045, X1046, X1047, X1048, X1049, X1050, X1051, X1050 X1053, X1054, X1055, X1056, X1057, X1058, X1059, X1060, X1061, X1062, X1063, X1064, X1065, X1066, X1067, X1068, X1069, X1070, X1071, X1072, X1073, X1074, X1075, X1076 , X1078, X1079, X1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1035, X1036 and / or X1044, X1045 and / or X1057, X1058 and / or X1064, X1065 and / or X1073, X1074 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1081, -NX1082X1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1084, -C (O) O-X1085, -C (O) NH-X1086, -C (O) NX1087X1088, -O-X1089, -O (-X1090-O) _j -H (j = 1, 2, 3, 4, 5), -O (-X1091-O) _j -X1092 (j = 1, 2, 3, 4, 5), -OC (O) -X1093, -OC (O) -O-X1094, -OC (O) -NHX1095, -O-C (O)- NX1096X1097, -OP (O) (OX1098) (OX1099), -OSi (X1100) (X1101) (X1102), -OS (O ₂ ) -X1103, -NHC (O) -X1104, -NX1105C (O) -X1106, -NH-C (O) -O-X1107, -NH-C (O) -NH-X1108, -NH-C (O ) -NX1109X1110, -NX1111-C (O) -O-X1112, -NX1113-C (O) -NH-X1114, -NX1115-C (O) -NX1116X1117, -NHS (O ₂ ) -X1118, -NX1119S (O ₂ ) -X1120, -S-X1121, -S (O) -X1122, -S (O ₂ ) -X1123, -S (O ₂ ) NH-X1124, -S (O ₂ ) NX1125X1126, -S (O ₂ ) O-X1127, -P (O) (OX1128) (OX1129), -Si (X1130) (X1131) (X1132) ";
At that time, X1081, X1082, X1083, X1084, X1085, X1086, X1087, X1088, X1089, X1090, X1091, X1092, X1093, X1094, X1095, X1096, X1097, X1098, X1099, X1100, X1101, X1102, X1103, X1104 X1105, X1106, X1107, X1108, X1109, X1110, X1111, X1112, X1113, X1114, X1115, X1116, X1117, X1118, X1119, X1120, X1121, X1122, X1123, X1124, X1125, X1126, X1127, X1128 , X1130, X1131, and X1132, independently of one another, represent “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1087, X1088 and / or X1096, X1097 and / or X1109, X1110 and / or X1116, X1117 and / or X1125, X1126 may each be taken together to form a "heterocyclyl";
(M) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -X1133, -C (O) O-X1134, -C (O)- NX1135X1136, -S (O ₂ ) -X1137, -S (O ₂ ) O-X1138 ";
In this case, X1133, X1134, X1135, X1136, X1137, and X1138 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, X1135, X1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1139, -NX1140X1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1142, -C (O) O-X1143, -C (O) NH-X1144, -C (O) NX1145X1146, -O-X1147, -O (-X1148-O) _k -H (k = 1, 2, 3, 4, 5), -O (-X1149-O) _k -X1150 (k = 1, 2, 3, 4, 5), -OC (O) -X1151, -OC (O) -O-X1152, -OC (O) -NHX1153, -O-C (O)- NX1154X1155, -OP (O) (OX1156) (OX1157), -OSi (X1158) (X1159) (X1160), -OS (O ₂ ) -X1161, -NHC (O) -X1162, -NX1163C (O) -X1164, -NH-C (O) -O-X1165, -NH-C (O) -NH-X1166, -NH-C (O ) -NX1167X1168, -NX1169-C (O) -O-X1170, -NX1171-C (O) -NH-X1172, -NX1173-C (O) -NX1174X1175, -NHS (O ₂ ) -X1176, -NX1177S (O ₂ ) -X1178, -S-X1179, -S (O) -X1180, -S (O ₂ ) -X1181, -S (O ₂ ) NH-X1182, -S (O ₂ ) NX1183X1184, -S (O ₂ ) O-X1185, -P (O) (OX1186) (OX1187), -Si (X1188) (X1189) (X1190) ";
At that time, X1139, X1140, X1141, X1142, X1143, X1144, X1145, X1146, X1147, X1148, X1149, X1150, X1151, X1152, X1153, X1154, X1155, X1156, X1157, X1158, X1159, X1160, X1161, X2160 X1163, X1164, X1165, X1166, X1167, X1168, X1169, X1170, X1171, X1172, X1173, X1174, X1175, X1176, X1177, X1178, X1179, X1180, X1181, X1182, X1183, X1186, X1185, X1186, X1185, X1186 , X1188, X1189, X1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1145, X1146 and / or X1154, X1155 and / or X 1167, X 1168 and / or X 1174, X 1175 and / or X 1183, X 1184 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHX1191, -NX1192X1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -X1194, -C (O) O-X1195, -C (O) NH-X1196, -C (O) NX1197X1198, -O-X1199, -O (-X1200-O) _l -H (l = 1, 2, 3, 4, 5), -O (-X1201-O) _l -X1202 (l = 1, 2, 3, 4, 5), -OC (O) -X1203, -OC (O) -O-X1204, -OC (O) -NHX1205, -O-C (O)- NX1206X1207, -OP (O) (OX1208) (OX1209), -OSi (X1210) (X1211) (X1212), -OS (O ₂ ) -X1213, -NHC (O) -X1214, -NX1215C (O) -X1216, -NH-C (O) -O-X1217, -NH-C (O) -NH-X1218, -NH-C (O ) -NX1219X1220, -NX1221-C (O) -O-X1222, -NX1223-C (O) -NH-X1224, -NX1225-C (O) -NX1226X1227, -NHS (O ₂ ) -X1228, -NX1229S (O ₂ ) -X1230, -S-X1231, -S (O) -X1232, -S (O ₂ ) -X1233, -S (O ₂ ) NH-X1234, -S (O ₂ ) NX1235X1236, -S (O ₂ ) O-X1237, -P (O) (OX1238) (OX1239), -Si (X1240) (X1241) (X1242) ";
In that case, X1191, X1192, X1193, X1194, X1195, X1196, X1197, X1198, X1199, X1200, X1201, X1202, X1203, X1204, X1205, X1206, X1207, X1208, X1209, X1210, X1211, X1212, X1213, X1213 , X1215, X1216, X1217, X1218, X1219, X1220, X1221, X1222, X1223, X1224, X1225, X1226, X1227, X1228, X1229, X1230, X1231, X1232, X1233, X1234, X1235, X1236, X1237, 3938 , X1240, X1241, and X1242 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally X1197, X1198 and / or X1206, X1207 and / or X1219, X1220 and / or X1226, X1227 and / or X1235, X1236 can each be taken together to form a “heterocyclyl”;
Or
(B)
One or both radicals Z3, Z4 of the radicals Z3, Z4, independently of one another, are “substituted heteroaryl”, wherein “substituted heteroaryl” is selected from the group consisting of Substituted with at least one substituent:
(A) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-V1, -N (alkyl) ₂ , —NHC (O) -alkyl, —NHC (O) -cycloalkyl, —NHC (O) -heterocyclyl, —NHC (O) -aryl, —NHC (O) -heteroaryl, —NHC (O) -aryl Alkyl, -NHC (O) -heteroarylalkyl, -NHS (O ₂ ) -Alkyl, -NHS (O ₂ ) -Cycloalkyl, -NHS (O ₂ ) -Heterocyclyl, -NHS (O ₂ ) -Aryl, -NHS (O ₂ ) -Heteroaryl, -NHS (O ₂ ) -Arylalkyl, -NHS (O ₂ ) -Heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -O-alkyl, -O-cycloalkyl, -O-cycloalkylalkyl, -O-aryl, -O-arylalkyl , -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclylalkyl, -OC (O) -alkyl, -OC (O) -cycloalkyl, -OC (O) -heterocyclyl, -OC (O) -Aryl, -OC (O) -heteroaryl, -OC (O) -arylalkyl, -OC (O) -heteroarylalkyl, -OS (O ₂ ) -Alkyl, -OS (O ₂ ) -Cycloalkyl, -OS (O ₂ ) -Heterocyclyl, -OS (O ₂ ) -Aryl, -OS (O ₂ ) -Heteroaryl, -OS (O ₂ ) -Arylalkyl, -OS (O ₂ ) -Heteroarylalkyl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl, -C (O) O-V2, -C (O) NH-V3,- C (O) N (alkyl) ₂ , -C (O) N (cycloalkyl) ₂ , -C (O) N (aryl) ₂ , -C (O) N (heteroaryl) ₂ , -S (O ₂ ) NH-alkyl, -S (O ₂ ) NH-aryl, -S (O ₂ ) NH-heteroaryl, -S (O ₂ ) NH-arylalkyl, S (O ₂ ) O-alkyl, -S (O ₂ ) O-aryl, -S (O ₂ ) O-arylalkyl ";
Wherein V1, V2, V3 are independently selected from the group consisting of “alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl”;
However, the above substituents of the substituent group (a) are further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N _Three , -NH-cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NV4V5, -S- Cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -O-cycloalkyl , -O-cycloalkylalkyl, -O-arylalkyl, -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclyl, -O-heterocyclylalkyl, -O (-V6-O) _p -H (p = 1, 2, 3, 4, 5), -O (-V7-O) _p -V8 (p = 1, 2, 3, 4, 5), -OP (O) (OV9) (OV10), -C (O) O-V11, -C (O) NH ₂ , -C (O) NH-V12, -C (O) NV13V14, -S (O ₂ ) -V15, -P (O) (OH) ₂ , -P (O) (OV16) (OV17), -Si (V18) (V19) (V20), -O-Si (V21) (V22) (V23), -O-C (O) -O-V24 , -O-C (O) -NH-V25, -O-C (O) -NV26V27, -NH-C (O) -O-V28, -NH-C (O) -NH-V29, -NH- C (O) -NV30V31, -NV32-C (O) -O-V33, -NV34-C (O) -NH-V35, -NV36-C (O) -NV37V38, -NV39-S (O ₂ ) -V40, -NH-S (O ₂ ) -V41, -O-S (O ₂ ) -V42, -NH-C (O) -V43, -NV44-C (O) -V45, -C (O) -V46, -OC (O) -V47, -S (O) -V48, -S (O ₂ ) -NHV49, -S (O ₂ ) -NV50V51, -S (O ₂ ) -OV52 ";
However, in addition, “—N (alkyl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (b);
At that time, V4, V5, V6, V7, V8, V9, V10, V11, V12, V13, V14, V15, V16, V17, V18, V19, V20, V21, V22, V23, V24, V25, V26, V27 , V28, V29, V30, V31, V32, V33, V34, V35, V36, V37, V38, V39, V40, V41, V42, V43, V44, V45, V46, V47, V48, V49, V50, V51, V52 Are independent of each other, "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, V13, V14 and / or V26, V27 and / or Or V30, V31 and / or V37, V38 and / or V50, V51 may be taken together to form a "heterocyclyl";
In that case, optionally additionally, one of the groups Z3, Z4, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(B) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV53, -NV54V55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V56, -C (O) O-V57, -C (O) NH-V58, -C (O) NV59V60, -O-V61, -O (-V62-O) _r -H (r = 1, 2, 3, 4, 5), -O (-V63-O) _r -V64 (r = 1, 2, 3, 4, 5), -OC (O) -V65, -OC (O) -O-V66, -OC (O) -NHV67, -O-C (O)- NV68V69, -OP (O) (OV70) (OV71), -OSi (V72) (V73) (V74), -OS (O ₂ ) -V75, -NHC (O) -V76, -NV77C (O) -V78, -NH-C (O) -O-V79, -NH-C (O) -NH-V80, -NH-C (O ) -NV81V82, -NV83-C (O) -O-V84, -NV85-C (O) -NH-V86, -NV87-C (O) -NV88V89, -NHS (O ₂ ) -V90, -NV91S (O ₂ ) -V92, -S-V93, -S (O) -V94, -S (O ₂ ) -V95, -S (O ₂ ) NH-V96, -S (O ₂ ) NV97V98, -S (O ₂ ) O-V99, -P (O) (OV100) (OV101), -Si (V102) (V103) (V104) ";
At that time, V53, V54, V55, V56, V57, V58, V59, V60, V61, V62, V63, V64, V65, V66, V67, V68, V69, V70, V71, V72, V73, V74, V75, V76 , V77, V78, V79, V80, V81, V82, V83, V84, V85, V86, V87, V88, V89, V90, V91, V92, V93, V94, V95, V96, V97, V98, V99, V100, V101 , V102, V103, V104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V59, V60 and / or V68, V69 and / or V81, V82 and / or V88, V89 and / or V97, V98 can be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (b) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV105, -NV106V107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V108, -C (O) O-V109, -C (O) NH-V110, -C (O) NV111V112, -O-V113, -O (-V114-O) _s -H (s = 1, 2, 3, 4, 5), -O (-V115-O) _s -V116 (s = 1, 2, 3, 4, 5), -OC (O) -V117, -OC (O) -O-V118, -OC (O) -NHV119, -O-C (O)- NV120V121, -OP (O) (OV122) (OV123), -OSi (V124) (V125) (V126), -OS (O ₂ ) -V127, -NHC (O) -V128, -NV129C (O) -V130, -NH-C (O) -O-V131, -NH-C (O) -NH-V132, -NH-C (O ) -NV133V134, -NV135-C (O) -O-V136, -NV137-C (O) -NH-V138, -NV139-C (O) -NV140V141, -NHS (O ₂ ) -V142, -NV143S (O ₂ ) -V144, -S-V145, -S (O) -V146, -S (O ₂ ) -V147, -S (O ₂ ) NH-V148, -S (O ₂ ) NV149V150, -S (O ₂ ) O-V151, -P (O) (OV152) (OV153), -Si (V154) (V155) (V156) ";
At that time, V105, V106, V107, V108, V109, V110, V111, V112, V113, V114, V115, V116, V117, V118, V119, V120, V121, V122, V123, V124, V125, V126, V127, V128 , V129, V130, V131, V132, V133, V134, V135, V136, V137, V138, V139, V140, V141, V142, V143, V144, V145, V146, V147, V148, V149, V150, V151, V152, V153 , V154, V155, V156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V111, V112 and / or V120, V121 and / or V133, V134 and / or V140, V141 and / or V149, V150 may be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV157, -NV158V159, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V160, -C (O) O-V161, -C (O) NH-V162, -C (O) NV163V164, -O-V165, -O (-V166-O) _t -H (t = 1, 2, 3, 4, 5), -O (-V167-O) _t -V168 (t = 1, 2, 3, 4, 5), -OC (O) -V169, -OC (O) -O-V170, -OC (O) -NHV171, -O-C (O)- NV172V173, -OP (O) (OV174) (OV175), -OSi (V176) (V177) (V178), -OS (O ₂ ) -V179, -NHC (O) -V180, -NV181C (O) -V182, -NH-C (O) -O-V183, -NH-C (O) -NH-V184, -NH-C (O ) -NV185V186, -NV187-C (O) -O-V188, -NV189-C (O) -NH-V190, -NV191-C (O) -NV192V193, -NHS (O ₂ ) -V194, -NV195S (O ₂ ) -V196, -S-V197, -S (O) -V198, -S (O ₂ ) -V199, -S (O ₂ ) NH-V200, -S (O ₂ ) NV201V202, -S (O ₂ ) O-V203, -P (O) (OV204) (OV205), -Si (V206) (V207) (V208) ";
At that time, V157, V158, V159, V160, V161, V162, V163, V164, V165, V166, V167, V168, V169, V170, V171, V172, V173, V174, V175, V176, V177, V178, V179, V180 , V181, V182, V183, V184, V185, V186, V187, V188, V189, V190, V191, V192, V193, V194, V195, V196, V197, V198, V199, V200, V201, V202, V203, V204, V205 , V206, V207, V208 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V163, V164 and / or V172, V173 and / or V185, V186 and / or V192, V193 and / or V201, V202 may be taken together to form a "heterocyclyl";
Or
One or both radicals Z3, Z4 of the radicals Z3, Z4 are, independently of one another, "substituted heteroaryl", wherein "substituted heteroaryl" consists of the following: Substituted by at least one substituent selected from the group:
(C) "C ₉ ~ C ₃₀ -Alkyl, -NV209V210, -NH-C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -cycloalkylalkyl, -NHC (O) -heterocyclylalkyl, -NHC (O) -C ₉ ~ C ₃₀ -Alkyl, -NV211C (O) -V212, -NV213C (O) -C ₉ ~ C ₃₀ -Alkyl, -NHC (O) -OV214, -NV215C (O) -OV216, -NHC (O) -NHV217, -NHC (O) -NV218V219, -NV220C (O) -NHV221, -NV222C (O) -NV223V224 , -NHS (O ₂ ) -Cycloalkylalkyl, -NHS (O ₂ ) -Heterocyclylalkyl, -NV225S (O ₂ ) -V226, -O-heterocyclyl, -O-C ₉ ~ C ₃₀ -Alkyl, -S-cycloalkyl, -S-heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S-cycloalkylalkyl, -S-heterocyclylalkyl, -S-C ₉ ~ C ₃₀ -Alkyl, -OC (O) -cycloalkylalkyl, -OC (O) -heterocyclylalkyl, -OC (O) -C ₉ ~ C ₃₀ -Alkyl, -OC (O) -OV227, -OC (O) -NHV228, -OC (O) -NV229V230, -OP (O) (OV231) (OV232), -OS (O ₂ ) -Cycloalkylalkyl, -OS (O ₂ ) -Heterocyclylalkyl, -OS (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -heterocyclyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -C (O) -cycloalkylalkyl,- C (O) -heterocyclylalkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) O-C ₉ ~ C ₃₀ -Alkyl, -C (O) NH-C ₉ ~ C ₃₀ -Alkyl, -C (O) NV233V234, -C (O) NH-OV235, -C (O) NV236-OV237, -C (O) NH-NV238V239, -C (O) NV240-NV241V242, -S (O ) -V243, -S (O ₂ ) -V244, -S (O ₂ ) NH-cycloalkyl, -S (O ₂ ) NH-heterocyclyl, -S (O ₂ ) NH-heteroarylalkyl, -S (O ₂ ) NH-cycloalkylalkyl, -S (O ₂ ) NH-heterocyclylalkyl, -S (O ₂ ) NH-C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) O-cycloalkyl, -S (O ₂ ) O-heterocyclyl, -S (O ₂ ) O-heteroaryl, -S (O ₂ ) O-heteroarylalkyl, -S (O ₂ ) O-cycloalkylalkyl, -S (O ₂ ) O-heterocyclylalkyl, -S (O ₂ ) O-C ₉ ~ C ₃₀ -Alkyl, -P (O) (OH) ₂ , -P (O) (OV245) (OV246), -Si (V247) (V248) (V247), -O-Si (V250) (V251) (V252) ";
At that time, V209, V210, V211, V212, V213, V214, V215, V216, V217, V218, V219, V220, V221, V222, V223, V224, V225, V226, V227, V228, V229, V230, V231, V232 , V233, V234, V235, V236, V237, V238, V239, V240, V241, V242, V243, V244, V245, V246, V247, V248, V249, V249, V250, V251, V252 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from V218, V219 and / or V223, V224 and / or Or V229, V230 and / or V233, V234 and / or V238, V239 and / or V241, V242 may each be taken together to form a "heterocyclyl";
Provided that the substituent "-N (alkyl) ₂ ","-C (O) N (alkyl) ₂ ","-C (O) N (cycloalkyl) ₂ ","-C (O) N (aryl) ₂ ","-C (O) N (heteroaryl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (i);
In this case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV253, -NV254V255, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V256, -C (O) O-V257, -C (O) NH-V258, -C (O) NV259V260, -O-V261, -O (-V262-O) _u -H (u = 1, 2, 3, 4, 5), -O (-V263-O) _u -V264 (u = 1, 2, 3, 4, 5), -OC (O) -V265, -OC (O) -O-V266, -OC (O) -NHV267, -O-C (O)- NV268V269, -OP (O) (OV270) (OV271), -OSi (V272) (V273) (V274), -OS (O ₂ ) -V275, -NHC (O) -V276, -NV277C (O) -V278, -NH-C (O) -O-V279, -NH-C (O) -NH-V280, -NH-C (O ) -NV281V282, -NV283-C (O) -O-V284, -NV285-C (O) -NH-V286, -NV287-C (O) -NV288V289, -NHS (O ₂ ) -V290, -NV291S (O ₂ ) -V292, -S-V293, -S (O) -V294, -S (O ₂ ) -V295, -S (O ₂ ) NH-V296, -S (O ₂ ) NV297V298, -S (O ₂ ) O-V299, -P (O) (OV300) (OV301), -Si (V302) (V303) (V304) ";
At that time, V253, V254, V255, V256, V257, V258, V259, V260, V261, V262, V263, V264, V265, V266, V267, V268, V269, V270, V271, V272, V273, V274, V275, V276 V277, V278, V279, V280, V281, V282, V283, V284, V285, V286, V287, V288, V289, V290, V291, V292, V293, V294, V295, V296, V297, V298, V299, V300, V299 , V302, V303, V304 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V259, V260 and / or V268, V269 and / or V281, V282 and / or V288, V289 and / or V297, V298 may be taken together to form a “heterocyclyl”;
In that case, optionally, one of the groups Z3, Z3, or in addition, both groups Z3, Z4, independently of one another, are selected from the group consisting of: It may be further substituted by one substituent:
(D) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV305, -NV306V307, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V308, -C (O) O-V309, -C (O) NH-V310, -C (O) NV311V312, -O-V313, -O (-V314-O) _v -H (v = 1, 2, 3, 4, 5), -O (-V315-O) _v -V316 (v = 1, 2, 3, 4, 5), -OC (O) -V317, -OC (O) -O-V318, -OC (O) -NHV319, -O-C (O)- NV320V321, -OP (O) (OV322) (OV323), -OSi (V324) (V325) (V326), -OS (O ₂ ) -V327, -NHC (O) -V328, -NV329C (O) -V330, -NH-C (O) -O-V331, -NH-C (O) -NH-V332, -NH-C (O ) -NV333V334, -NV335-C (O) -O-V336, -NV337-C (O) -NH-V338, -NV339-C (O) -NV340V341, -NHS (O ₂ ) -V342, -NV343S (O ₂ ) -V344, -S-V345, -S (O) -V346, -S (O ₂ ) -V347, -S (O ₂ ) NH-V348, -S (O ₂ ) NV349V350, -S (O ₂ ) O-V351, -P (O) (OV352) (OV353), -Si (V354) (V355) (V356) ";
At that time, V305, V306, V307, V308, V309, V310, V311, V312, V313, V314, V315, V316, V317, V318, V319, V320, V321, V322, V323, V324, V325, V326, V327, V328 , V329, V330, V331, V332, V333, V334, V335, V336, V337, V338, V339, V340, V341, V342, V343, V344, V345, V346, V347, V348, V349, V350, V351, V352, 353 , V354, V355, V356 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V311, V312 and / or V320, V321 and / or V333, V334 and / or V340, V341 and / or V349, V350 may be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (d) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV357, -NV358V359, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V360, -C (O) O-V361, -C (O) NH-V362, -C (O) NV363V364, -O-V365, -O (-V366-O) _w -H (w = 1, 2, 3, 4, 5), -O (-V367-O) _w -V368 (w = 1, 2, 3, 4, 5), -OC (O) -V369, -OC (O) -O-V370, -OC (O) -NHV371, -O-C (O)- NV372V373, -OP (O) (OV374) (OV375), -OSi (V376) (V377) (V378), -OS (O ₂ ) -V379, -NHC (O) -V380, -NV381C (O) -V382, -NH-C (O) -O-V383, -NH-C (O) -NH-V384, -NH-C (O ) -NV385V386, -NV387-C (O) -O-V388, -NV389-C (O) -NH-V390, -NV391-C (O) -NV392V393, -NHS (O ₂ ) -V394, -NV395S (O ₂ ) -V396, -S-V397, -S (O) -V398, -S (O ₂ ) -V399, -S (O ₂ ) NH-V400, -S (O ₂ ) NV401V402, -S (O ₂ ) O-V403, -P (O) (OV404) (OV405), -Si (V406) (V407) (V408) ";
At that time, V357, V358, V359, V360, V361, V362, V363, V364, V365, V366, V367, V368, V369, V370, V371, V372, V373, V374, V375, V376, V377, V378, V379, V379 , V381, V382, V383, V384, V385, V386, V387, V388, V389, V390, V391, V392, V393, V394, V395, V396, V397, V398, V399, V400, V401, V402, V403, V404, V405 , V406, V407, V408 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V363, V364 and / or V372, V373 and / or V385, V386 and / or V392, V393 and / or V401, V402 may be taken together to form a "heterocyclyl";
In this case, depending on the case, the substituents of the substituent group (i) and / or the substituent group (ii) are at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other: It may be further substituted by a group:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV409, -NV410V411, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V412, -C (O) O-V413, -C (O) NH-V414, -C (O) NV415V416, -O-V417, -O (-V418-O) _x -H (x = 1, 2, 3, 4, 5), -O (-V419-O) _x -V420 (x = 1, 2, 3, 4, 5), -OC (O) -V421, -OC (O) -O-V422, -OC (O) -NHV423, -O-C (O)- NV424V425, -OP (O) (OV426) (OV427), -OSi (V428) (V429) (V430), -OS (O ₂ ) -V431, -NHC (O) -V432, -NV433C (O) -V434, -NH-C (O) -O-V435, -NH-C (O) -NH-V436, -NH-C (O ) -NV437V438, -NV439-C (O) -O-V440, -NV441-C (O) -NH-V442, -NV443-C (O) -NV444V445, -NHS (O ₂ ) -V446, -NV447S (O ₂ ) -V448, -S-V449, -S (O) -V450, -S (O ₂ ) -V451, -S (O ₂ ) NH-V452, -S (O ₂ ) NV453V454, -S (O ₂ ) O-V455, -P (O) (OV456a) (OV456b), -Si (V456c) (V456d) (V456e) ";
At that time, V409, V410, V411, V412, V413, V414, V415, V416, V417, V418, V419, V420, V421, V422, V423, V424, V425, V426, V427, V428, V429, V430, V431, V432 , V433, V434, V435, V436, V437, V438, V439, V440, V441, V442, V443, V444, V445, V446, V447, V448, V449, V450, V451, V452, V453, V454, V455, V456b , V456c, V456d, and V456e are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V415, V416 and / or V424, V425 and / or V437, V438 and / or V444, V445 and / or V453, V454 may be taken together to form a “heterocyclyl”;
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(E) hydrogen;
(F) halogen, F, Cl, Br, I;
(G) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV457, -NV458V459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V460, -C (O) O-V461, -C (O) NH-V462, -C (O) NV463V464, -O-V465, -O (-V466-O) _y -H (y = 1, 2, 3, 4, 5), -O (-V467-O) _y -V468 (y = 1, 2, 3, 4, 5), -OC (O) -V469, -OC (O) -O-V470, -OC (O) -NHV471, -O-C (O)- NV472V473, -OP (O) (OV474) (OV475), -OSi (V476) (V477) (V478), -OS (O ₂ ) -V479, -NHC (O) -V480, -NV481C (O) -V482, -NH-C (O) -O-V483, -NH-C (O) -NH-V484, -NH-C (O ) -NV485V486, -NV487-C (O) -O-V488, -NV489-C (O) -NH-V490, -NV491-C (O) -NV492V493, -NHS (O ₂ ) -V494, -NV495S (O ₂ ) -V496, -S-V497, -S (O) -V498, -S (O ₂ ) -V499, -S (O ₂ ) NH-V500, -S (O ₂ ) NV501V502, -S (O ₂ ) O-V503, -P (O) (OV504) (OV505), -Si (V506) (V507) (V508) ";
At that time, V457, V458, V459, V460, V461, V462, V463, V464, V465, V466, V467, V468, V469, V470, V471, V472, V473, V474, V475, V476, V477, V478, V480, V479 , V481, V482, V483, V484, V485, V486, V487, V488, V489, V490, V491, V492, V493, V494, V495, V496, V497, V498, V499, V500, V501, V502, V503, V504, V504 , V506, V507, V508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V463, V464 and / or V472, V473 and / or V485, V486 and / or V492, V493 and / or V501, V502 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV509, -NV510V511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V512, -C (O) O-V513, -C (O) NH-V514, -C (O) NV515V516, -O-V517, -O (-V518-O) _z -H (z = 1, 2, 3, 4, 5), -O (-V519-O) _z -V520 (z = 1, 2, 3, 4, 5), -OC (O) -V521, -OC (O) -O-V522, -OC (O) -NHV523, -O-C (O)- NV524V525, -OP (O) (OV526) (OV527), -OSi (V528) (V529) (V530), -OS (O ₂ ) -V531, -NHC (O) -V532, -NV533C (O) -V534, -NH-C (O) -O-V535, -NH-C (O) -NH-V536, -NH-C (O ) -NV537V538, -NV539-C (O) -O-V540, -NV541-C (O) -NH-V542, -NV543-C (O) -NV544V545, -NHS (O ₂ ) -V546, -NV547S (O ₂ ) -V548, -S-V549, -S (O) -V550, -S (O ₂ ) -V551, -S (O ₂ ) NH-V552, -S (O ₂ ) NV553V554, -S (O ₂ ) O-V555, -P (O) (OV556) (OV557), -Si (V558) (V559) (V560) ";
At that time, V509, V510, V511, V512, V513, V514, V515, V516, V517, V518, V519, V520, V521, V522, V523, V524, V525, V526, V527, V528, V529, V530, V531, V532 , V533, V534, V535, V536, V537, V538, V539, V540, V541, V542, V543, V544, V545, V546, V547, V548, V549, V550, V551, V552, V553, V554, V555, V556 , V558, V559, V560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V515, V516 and / or V524, V525 and / or V537, V538 and / or V544, V545 and / or V553, V554 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV561, -NV562V563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V564, -C (O) O-V565, -C (O) NH-V566, -C (O) NV567V568, -O-V569, -O (-V570-O) _a -H (a = 1, 2, 3, 4, 5), -O (-V571-O) _a -V572 (a = 1, 2, 3, 4, 5), -OC (O) -V573, -OC (O) -O-V574, -OC (O) -NHV575, -O-C (O)- NV576V577, -OP (O) (OV578) (OV579), -OSi (V580) (V581) (V582), -OS (O ₂ ) -V583, -NHC (O) -V584, -NV585C (O) -V586, -NH-C (O) -O-V587, -NH-C (O) -NH-V588, -NH-C (O ) -NV589V590, -NV591-C (O) -O-V592, -NV593-C (O) -NH-V594, -NV595-C (O) -NV596V597, -NHS (O ₂ ) -V598, -NV599S (O ₂ ) -V600, -S-V601, -S (O) -V602, -S (O ₂ ) -V603, -S (O ₂ ) NH-V604, -S (O ₂ ) NV605V606, -S (O ₂ ) O-V607, -P (O) (OV608) (OV609), -Si (V610) (V611) (V612) ";
At that time, V561, V562, V563, V564, V565, V566, V567, V568, V569, V570, V571, V572, V573, V574, V575, V576, V577, V578, V579, V580, V581, V582, V58 , V585, V586, V587, V588, V589, V590, V591, V592, V593, V594, V595, V596, V597, V598, V599, V600, V601, V602, V603, V604, V605, V606, V607, V608, V607 , V610, V611, V612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V567, V568 and / or V576, V577 and / or V589, V590 and / or V596, V597 and / or V605, V606 may each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV613, -NV614V615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V616, -C (O) O-V617, -C (O) NH-V618, -C (O) NV619V620, -O-V621, -O (-V622-O) _b -H (b = 1, 2, 3, 4, 5), -O (-V623-O) _b -V624 (b = 1, 2, 3, 4, 5), -OC (O) -V625, -OC (O) -O-V626, -OC (O) -NHV627, -O-C (O)- NV628V629, -OP (O) (OV630) (OV631), -OSi (V632) (V633) (V634), -OS (O ₂ ) -V635, -NHC (O) -V636, -NV637C (O) -V638, -NH-C (O) -O-V639, -NH-C (O) -NH-V640, -NH-C (O ) -NV641V642, -NV643-C (O) -O-V644, -NV645-C (O) -NH-V646, -NV647-C (O) -NV648V649, -NHS (O ₂ ) -V650, -NV651S (O ₂ ) -V652, -S-V653, -S (O) -V654, -S (O ₂ ) -V655, -S (O ₂ ) NH-V656, -S (O ₂ ) NV657V658, -S (O ₂ ) O-V659, -P (O) (OV660) (OV661), -Si (V662) (V663) (V664) ";
At that time, V613, V614, V615, V616, V617, V618, V619, V620, V621, V622, V623, V624, V625, V626, V627, V628, V629, V630, V631, V632, V633, V634, V635, V636 , V637, V638, V639, V640, V641, V642, V643, V644, V645, V646, V647, V648, V649, V650, V651, V652, V653, V654, V655, V656, V657, V658, V659, V660, V659, V660 , V662, V663, V664 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V619, V620 and / or V628, V629 and / or V641, V642 and / or V648, V649 and / or V657, V658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV665, -NV666V667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V668, -C (O) O-V669, -C (O) NH-V670, -C (O) NV671V672, -O-V673, -O (-V674-O) _c -H (c = 1, 2, 3, 4, 5), -O (-V675-O) _c -V676 (c = 1, 2, 3, 4, 5), -OC (O) -V677, -OC (O) -O-V678, -OC (O) -NHV679, -O-C (O)- NV680V681, -OP (O) (OV682) (OV683), -OSi (V684) (V685) (V686), -OS (O ₂ ) -V687, -NHC (O) -V688, -NV689C (O) -V690, -NH-C (O) -O-V691, -NH-C (O) -NH-V692, -NH-C (O ) -NV693V694, -NV695-C (O) -O-V696, -NV697-C (O) -NH-V698, -NV699-C (O) -NV700V701, -NHS (O ₂ ) -V702, -NV703S (O ₂ ) -V704, -S-V705, -S (O) -V706, -S (O ₂ ) -V707, -S (O ₂ ) NH-V708, -S (O ₂ ) NV709V710, -S (O ₂ ) O-V711, -P (O) (OV712) (OV713), -Si (V714) (V715) (V716) ";
At that time, V665, V666, V667, V668, V669, V670, V671, V672, V673, V674, V675, V676, V677, V678, V679, V680, V681, V682, V683, V684, V685, V686, V687, V687 , V689, V690, V691, V692, V693, V694, V695, V696, V697, V698, V699, V700, V701, V702, V703, V704, V705, V706, V707, V708, V709, V710, V711, V712, V711, V712 , V714, V715, V716 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V671, V672 and / or V680, V681 and / or V693, V694 and / or V700, V701 and / or V709, V710 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV717, -NV718V719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V720, -C (O) O-V721, -C (O) NH-V722, -C (O) NV723V724, -O-V725, -O (-V726-O) _d -H (d = 1, 2, 3, 4, 5), -O (-V727-O) _d -V728 (d = 1, 2, 3, 4, 5), -OC (O) -V729, -OC (O) -O-V730, -OC (O) -NHV731, -O-C (O)- NV732V733, -OP (O) (OV734) (OV735), -OSi (V736) (V737) (V738), -OS (O ₂ ) -V739, -NHC (O) -V740, -NV741C (O) -V742, -NH-C (O) -O-V743, -NH-C (O) -NH-V744, -NH-C (O ) -NV745V746, -NV747-C (O) -O-V748, -NV749-C (O) -NH-V750, -NV751-C (O) -NV752V753, -NHS (O ₂ ) -V754, -NV755S (O ₂ ) -V756, -S-V757, -S (O) -V758, -S (O ₂ ) -V759, -S (O ₂ ) NH-V760, -S (O ₂ ) NV761V762, -S (O ₂ ) O-V763, -P (O) (OV764) (OV765), -Si (V766) (V767) (V768) ";
At that time, V717, V718, V719, V720, V721, V722, V723, V724, V725, V726, V727, V728, V729, V730, V731, V732, V733, V734, V735, V736, V737, V738, V739, V739 , V741, V742, V743, V744, V745, V746, V747, V748, V749, V750, V751, V752, V753, V754, V755, V756, V757, V758, V759, V760, V761, V762, V763, 764 , V766, V767, V768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V723, V724 and / or V732, V733 and / or V745, V746 and / or V752, V753 and / or V761, V762 can each be taken together to form a "heterocyclyl";
(J) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV769, -NV770V771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V772, -C (O) O-V773, -C (O) NH-V774, -C (O) NV775V776, -O-V777, -O (-V778-O). _e -H (e = 1, 2, 3, 4, 5), -O (-V779-O) _e -V780 (e = 1, 2, 3, 4, 5), -OC (O) -V781, -OC (O) -O-V782, -OC (O) -NHV783, -O-C (O)- NV784V785, -OP (O) (OV786) (OV787), -OSi (V788) (V789) (V790), -OS (O ₂ ) -V791, -NHC (O) -V792, -NV793C (O) -V794, -NH-C (O) -O-V795, -NH-C (O) -NH-V796, -NH-C (O ) -NV797V798, -NV799-C (O) -O-V800, -NV801-C (O) -NH-V802, -NV803-C (O) -NV804V805, -NHS (O ₂ ) -V806, -NV807S (O ₂ ) -V808, -S-V809, -S (O) -V810, -S (O ₂ ) -V811, -S (O ₂ ) NH-V812, -S (O ₂ ) NV813V814, -S (O ₂ ) O-V815, -P (O) (OV816) (OV817), -Si (V818) (V819) (V820) ";
At that time, V769, V770, V771, V772, V773, V774, V775, V776, V777, V778, V779, V780, V781, V782, V783, V784, V785, V786, V787, V788, V789, V790, V791, V791 , V793, V794, V795, V796, V797, V798, V799, V800, V801, V802, V803, V804, V805, V806, V807, V808, V809, V810, V811, V812, V813, V814, V815, V816, V815, V816 , V818, V819, V820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V775, V776 and / or V784, V785 and / or V797, V798 and / or V804, V805 and / or V813, V814 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV821, -NV822V823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V824, -C (O) O-V825, -C (O) NH-V826, -C (O) NV827V828, -O-V829, -O (-V830-O) _f -H (f = 1, 2, 3, 4, 5), -O (-V831-O) _f -V832 (f = 1, 2, 3, 4, 5), -OC (O) -V833, -OC (O) -O-V834, -OC (O) -NHV835, -O-C (O)- NV836V837, -OP (O) (OV838) (OV839), -OSi (V840) (V841) (V842), -OS (O ₂ ) -V843, -NHC (O) -V844, -NV845C (O) -V846, -NH-C (O) -O-V847, -NH-C (O) -NH-V848, -NH-C (O ) -NV849V850, -NV851-C (O) -O-V852, -NV853-C (O) -NH-V854, -NV855-C (O) -NV856V857, -NHS (O ₂ ) -V858, -NV859S (O ₂ ) -V860, -S-V861, -S (O) -V862, -S (O ₂ ) -V863, -S (O ₂ ) NH-V864, -S (O ₂ ) NV865V866, -S (O ₂ ) O-V867, -P (O) (OV868) (OV869), -Si (V870) (V871) (V872) ";
At that time, V821, V822, V823, V824, V825, V826, V827, V828, V829, V830, V831, V832, V833, V834, V835, V836, V837, V838, V833, V840, V841, V842, V84, V84 , V845, V846, V847, V848, V849, V850, V851, V852, V853, V854, V855, V856, V857, V858, V859, V860, V861, V862, V863, V864, V865, V866, V867, 86 , V870, V871, V872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V827, V828 and / or V836, V837 and / or V849, V850 and / or V856, V857 and / or V865, V866 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV873, -NV874V875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V876, -C (O) O-V877, -C (O) NH-V878, -C (O) NV879V880, -O-V881, -O (-V882-O) _g -H (g = 1, 2, 3, 4, 5), -O (-V883-O) _g -V884 (g = 1, 2, 3, 4, 5), -OC (O) -V885, -OC (O) -O-V886, -OC (O) -NHV887, -O-C (O)- NV888V889, -OP (O) (OV890) (OV891), -OSi (V892) (V893) (V894), -OS (O ₂ ) -V895, -NHC (O) -V896, -NV897C (O) -V898, -NH-C (O) -O-V899, -NH-C (O) -NH-V900, -NH-C (O ) -NV901V902, -NV903-C (O) -O-V904, -NV905-C (O) -NH-V906, -NV907-C (O) -NV908V909, -NHS (O ₂ ) -V910, -NV911S (O ₂ ) -V912, -S-V913, -S (O) -V914, -S (O ₂ ) -V915, -S (O ₂ ) NH-V916, -S (O ₂ ) NV917V918, -S (O ₂ ) O-V919, -P (O) (OV920) (OV921), -Si (V922) (V923) (V924) ";
In that case, V873, V874, V875, V876, V877, V878, V879, V880, V881, V882, V883, V88, V885, V886, V887, V888, V889, V890, V891, V892, V893, V894, V895, V895 , V897, V898, V899, V900, V901, V902, V903, V904, V905, V906, V907, V908, V909, V910, V911, V912, V913, V914, V915, V916, V917, V918, V919, V920 , V922, V923, V924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V879, V880 and / or V888, V889 and / or V901, V902 and / or V908, V909 and / or V917, V918 can each be taken together to form a "heterocyclyl";
(K) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV925, -NV926V927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V928, -C (O) O-V929, -C (O) NH-V930, -C (O) NV931V932, -O-V933, -O (-V934-O) _h -H (h = 1, 2, 3, 4, 5), -O (-V935-O) _h -V936 (h = 1, 2, 3, 4, 5), -OC (O) -V937, -OC (O) -O-V938, -OC (O) -NHV939, -O-C (O)- NV940V941, -OP (O) (OV942) (OV943), -OSi (V944) (V945) (V946), -OS (O ₂ ) -V947, -NHC (O) -V948, -NV949C (O) -V950, -NH-C (O) -O-V951, -NH-C (O) -NH-V952, -NH-C (O ) -NV953V954, -NV955-C (O) -O-V956, -NV957-C (O) -NH-V958, -NV959-C (O) -NV960V961, -NHS (O ₂ ) -V962, -NV963S (O ₂ ) -V964, -S-V965, -S (O) -V966, -S (O ₂ ) -V967, -S (O ₂ ) NH-V968, -S (O ₂ ) NV969V970, -S (O ₂ ) O-V971, -P (O) (OV972) (OV973), -Si (V974) (V975) (V976) ";
At that time, V925, V926, V927, V928, V929, V930, V931, V932, V933, V934, V935, V936, V937, V938, V939, V940, V941, V942, V943, V944, V945, V946, V947, V948 , V949, V950, V951, V952, V953, V954, V955, V955, V957, V958, V959, V960, V961, V962, V963, V964, V965, V966, V967, V968, V969, V970, V971, V972 , V974, V975, V976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V931, V932 and / or V940, V941 and / or V953, V954 and / or V960, V961 and / or V969, V970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV977, -NV978V979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V980, -C (O) O-V981, -C (O) NH-V982, -C (O) NV983V984, -O-V985, -O (-V986-O) _i -H (i = 1, 2, 3, 4, 5), -O (-V987-O) _i -V988 (i = 1, 2, 3, 4, 5), -OC (O) -V989, -OC (O) -O-V990, -OC (O) -NHV991, -O-C (O)- NV992V993, -OP (O) (OV994) (OV995), -OSi (V996) (V997) (V998), -OS (O ₂ ) -V999, -NHC (O) -V1000, -NV1001C (O) -V1002, -NH-C (O) -O-V1003, -NH-C (O) -NH-V1004, -NH-C (O ) -NV1005V1006, -NV1007-C (O) -O-V1008, -NV1009-C (O) -NH-V1010, -NV1011-C (O) -NV1012V1013, -NHS (O ₂ ) -V1014, -NV1015S (O ₂ ) -V1016, -S-V1017, -S (O) -V1018, -S (O ₂ ) -V1019, -S (O ₂ ) NH-V1020, -S (O ₂ ) NV1021V1022, -S (O ₂ ) O-V1023, -P (O) (OV1024) (OV1025), -Si (V1026) (V1027) (V1028) ";
At that time, V977, V978, V979, V980, V981, V982, V983, V984, V985, V986, V987, V988, V989, V990, V991, V992, V993, V994, V995, V996, V997, V998, V999, 1000 , V1001, V1002, V1003, V1004, V1005, V1006, V1007, V1008, V1009, V1010, V1011, V1012, V1013, V1014, V1015, V1016, V1017, V1018, V1019, V1020, V1021, V1022, V1023, V1024 , V1026, V1027, V1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V983, V984 and / or V992, V993 and / or V1005, V1006 and / or V1012, V1013 and / or V1021, V1022 can each be taken together to form a "heterocyclyl";
(L) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1029, -NV1030V1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1032, -C (O) O-V1033, -C (O) NH-V1034, -C (O) NV1035V1036, -O-V1037, -O (-V1038-O) _j -H (j = 1, 2, 3, 4, 5), -O (-V1039-O) _j -V1040 (j = 1, 2, 3, 4, 5), -OC (O) -V1041, -OC (O) -O-V1042, -OC (O) -NHV1043, -O-C (O)- NV1044V1045, -OP (O) (OV1046) (OV1047), -OSi (V1048) (V1049) (V1050), -OS (O ₂ ) -V1051, -NHC (O) -V1052, -NV1053C (O) -V1054, -NH-C (O) -O-V1055, -NH-C (O) -NH-V1056, -NH-C (O ) -NV1057V1058, -NV1059-C (O) -O-V1060, -NV1061-C (O) -NH-V1062, -NV1063-C (O) -NV1064V1065, -NHS (O ₂ ) -V1066, -NV1067S (O ₂ ) -V1068, -S-V1069, -S (O) -V1070, -S (O ₂ ) -V1071, -S (O ₂ ) NH-V1072, -S (O ₂ ) NV1073V1074, -S (O ₂ ) O-V1075, -P (O) (OV1076) (OV1077), -Si (V1078) (V1079) (V1080) ";
At that time, V1029, V1030, V1031, V1032, V1033, V1034, V1035, V1036, V1037, V1038, V1039, V1040, V1041, V1042, V1043, V1044, V1045, V1046, V1047, V1048, V1049, V1050, V1051, V1052, . , V1078, V1079, V1080 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1035, V1036 and / or V1044, V1045 and / or V1057, V1058 and / or V1064, V1065 and / or V1073, V1074 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1081, -NV1082V1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1084, -C (O) O-V1085, -C (O) NH-V1086, -C (O) NV1087V1088, -O-V1089, -O (-V1090-O) _k -H (k = 1, 2, 3, 4, 5), -O (-V1091-O) _k -V1092 (k = 1, 2, 3, 4, 5), -OC (O) -V1093, -OC (O) -O-V1094, -OC (O) -NHV1095, -O-C (O)- NV1096V1097, -OP (O) (OV1098) (OV1099), -OSi (V1100) (V1101) (V1102), -OS (O ₂ ) -V1103, -NHC (O) -V1104, -NV1105C (O) -V1106, -NH-C (O) -O-V1107, -NH-C (O) -NH-V1108, -NH-C (O ) -NV1109V1110, -NV1111-C (O) -O-V1112, -NV1113-C (O) -NH-V1114, -NV1115-C (O) -NV1116V1117, -NHS (O ₂ ) -V1118, -NV1119S (O ₂ ) -V1120, -S-V1121, -S (O) -V1122, -S (O ₂ ) -V1123, -S (O ₂ ) NH-V1124, -S (O ₂ ) NV1125V1126, -S (O ₂ ) O-V1127, -P (O) (OV1128) (OV1129), -Si (V1130) (V1131) (V1132) ";
At that time, V1081, V1082, V1083, V1084, V1085, V1086, V1087, V1088, V1089, V1090, V1091, V1092, V1093, V1094, V1095, V1096, V1097, V1098, V1099, V1100, V1101, V1102, V1103, V1104 , V1105, V1106, V1107, V1108, V1109, V1110, V1111, V1112, V1113, V1114, V1115, V1116, V1117, V1118, V1119, V1120, V1121, V1122, V1123, V1124, V1125, V1126, V1127, V1128 , V1130, V1131, V1132, independently of one another, are “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1087, V1088 and / or V1096, V1097 and / or V1109, V1110 and / or V1116, V1117 and / or V1125, V1126 may each be taken together to form a "heterocyclyl";
(M) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -V1133, -C (O) O-V1134, -C (O)- NV1135V1136, -S (O ₂ ) -V1137, -S (O ₂ ) O-V1138 ";
At that time, V1133, V1134, V1135, V1136, V1137, and V1138 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, V1135, V1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1139, -NV1140V1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1142, -C (O) O-V1143, -C (O) NH-V1144, -C (O) NV1145V1146, -O-V1147, -O (-V1148-O) _l -H (l = 1, 2, 3, 4, 5), -O (-V1149-O) _l -V1150 (l = 1, 2, 3, 4, 5), -OC (O) -V1151, -OC (O) -O-V1152, -OC (O) -NHV1153, -O-C (O)- NV1154V1155, -OP (O) (OV1156) (OV1157), -OSi (V1158) (V1159) (V1160), -OS (O ₂ ) -V1161, -NHC (O) -V1162, -NV1163C (O) -V1164, -NH-C (O) -O-V1165, -NH-C (O) -NH-V1166, -NH-C (O ) -NV1167V1168, -NV1169-C (O) -O-V1170, -NV1171-C (O) -NH-V1172, -NV1173-C (O) -NV1174V1175, -NHS (O ₂ ) -V1176, -NV1177S (O ₂ ) -V1178, -S-V1179, -S (O) -V1180, -S (O ₂ ) -V1181, -S (O ₂ ) NH-V1182, -S (O ₂ ) NV1183V1184, -S (O ₂ ) O-V1185, -P (O) (OV1186) (OV1187), -Si (V1188) (V1189) (V1190) ";
At that time, V1139, V1140, V1141, V1142, V1143, V1144, V1145, V1146, V1147, V1148, V1149, V1150, V1151, V1152, V1153, V1154, V1155, V1156, V1157, V1158, V1159, V1160, V1160, V1160 , V1163, V1164, V1165, V1166, V1167, V1168, V1169, V1170, V1171, V1172, V1173, V1174, V1175, V1176, V1177, V1178, V1179, V1180, V1181, V1182, V1183, V1186, V1185, V1186, , V1188, V1189, and V1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1145, V1146 and / or V1154, V1155 and / or V1167, V1168 and / or V1174, V1175 and / or V1183, V1184 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHV1191, -NV1192V1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -V1194, -C (O) O-V1195, -C (O) NH-V1196, -C (O) NV1197V1198, -O-V1199, -O (-V1200-O). _m -H (m = 1, 2, 3, 4, 5), -O (-V1201-O) _m -V1202 (m = 1, 2, 3, 4, 5), -OC (O) -V1203, -OC (O) -O-V1204, -OC (O) -NHV1205, -O-C (O)- NV1206V1207, -OP (O) (OV1208) (OV1209), -OSi (V1210) (V1211) (V1212), -OS (O ₂ ) -V1213, -NHC (O) -V1214, -NV1215C (O) -V1216, -NH-C (O) -O-V1217, -NH-C (O) -NH-V1218, -NH-C (O ) -NV1219V1220, -NV1221-C (O) -O-V1222, -NV1223-C (O) -NH-V1224, -NV1225-C (O) -NV1226V1227, -NHS (O ₂ ) -V1228, -NV1229S (O ₂ ) -V1230, -S-V1231, -S (O) -V1232, -S (O ₂ ) -V1233, -S (O ₂ ) NH-V1234, -S (O ₂ ) NV1235V1236, -S (O ₂ ) O-V1237, -P (O) (OV1238) (OV1239), -Si (V1240) (V1241) (V1242) ";
At that time, V1191, V1192, V1193, V1194, V1195, V1196, V1197, V1198, V1199, V1200, V1201, V1202, V1203, V1204, V1205, V1206, V1207, V1208, V1209, V1210, V1211, V1212, V1213, V1213 , V1215, V1216, V1217, V1218, V1219, V1220, V1221, V1222, V1223, V1224, V1225, V1226, V1227, V1228, V1229, V1230, V1231, V1232, V1233, V1234, V1235, V1236, V1237, V1238 , V1240, V1241, and V1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally V1197, V1198 and / or V1206, V1207 and / or V1219, V1220 and / or V1226, V1227 and / or V1235, V1236 can each be taken together to form a "heterocyclyl";
Or
(C)
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are “substituted alkyl”, wherein “substituted alkyl” is selected from the group consisting of: Substituted by at least one substituent:
(A) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1, -NW2W3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W4, -C (O) O-W5, -C (O) NH-W6, -C (O) NW7W8, -O-W9, -O (-W10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-W11-O) _r -W12 (r = 1, 2, 3, 4, 5), -OC (O) -W13, -OC (O) -O-W14, -OC (O) -NHW15, -O-C (O)- NW16W17, -OP (O) (OW18) (OW19), -OSi (W20) (W21) (W22), -OS (O ₂ ) -W23, -NHC (O) -W24, -NW25C (O) -W26, -NH-C (O) -O-W27, -NH-C (O) -NH-W28, -NH-C (O ) -NW29W30, -NW31-C (O) -O-W32, -NW33-C (O) -NH-W34, -NW35-C (O) -NW36W37, -NHS (O ₂ ) -W38, -NW39S (O ₂ ) -W40, -S-W41, -S (O) -W42, -S (O ₂ ) -W43, -S (O ₂ ) NH-W44, -S (O ₂ ) NW45W46, -S (O ₂ ) O-W47, -P (O) (OW48) (OW49), -Si (W50) (W51) (W52) ";
At that time, W1, W2, W3, W4, W5, W6, W7, W8, W9, W10, W11, W12, W13, W14, W15, W16, W17, W18, W19, W20, W21, W22, W23, W24 , W25, W26, W27, W28, W29, W30, W31, W32, W33, W34, W35, W36, W37, W38, W39, W40, W41, W42, W43, W44, W45, W46, W47, W48, W49 , W50, W51, W52 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, W7, W8 and / or W16, W17 and / or Or W29, W30 and / or W36, W37 and / or W45, W46 may each be taken together to form a "heterocyclyl";
However, "-C (O) NH-aryl", "-C (O) NH-heteroaryl", "-C (O) NH-cycloalkyl", "-C (O) NH-heterocyclyl" Further substituted with at least one substituent selected from the substituent group (i)
In this case, the substituents of the substituent group (a) may optionally be further substituted with at least one substituent selected from the group consisting of the following, independently or from the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW53, -NW54W55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W56, -C (O) O-W57, -C (O) NH-W58, -C (O) NW59W60, -O-W61, -O (-W62-O) _s -H (s = 1, 2, 3, 4, 5), -O (-W63-O) _s -W64 (s = 1, 2, 3, 4, 5), -OC (O) -W65, -OC (O) -O-W66, -OC (O) -NHW67, -O-C (O)- NW68W69, -OP (O) (OW70) (OW71), -OSi (W72) (W73) (W74), -OS (O ₂ ) -W75, -NHC (O) -W76, -NW77C (O) -W78, -NH-C (O) -O-W79, -NH-C (O) -NH-W80, -NH-C (O ) -NW81W82, -NW83-C (O) -O-W84, -NW85-C (O) -NH-W86, -NW87-C (O) -NW88W89, -NHS (O ₂ ) -W90, -NW91S (O ₂ ) -W92, -S-W93, -S (O) -W94, -S (O ₂ ) -W95, -S (O ₂ ) NH-W96, -S (O ₂ ) NW97W98, -S (O ₂ ) O-W99, -P (O) (OW100) (OW101), -Si (W102) (W103) (W104) ";
At that time, W53, W54, W55, W56, W57, W58, W59, W60, W61, W62, W63, W64, W65, W66, W67, W68, W69, W70, W71, W72, W73, W74, W75, W76 W77, W78, W79, W80, W81, W82, W83, W84, W85, W86, W87, W88, W89, W90, W91, W92, W93, W94, W95, W96, W97, W98, W99, W100, W101 , W102, W103, W104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W59, W60 and / or W68, W69 and / or W81, W82 and / or W88, W89 and / or W97, W98 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW105, -NW106W107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W108, -C (O) O-W109, -C (O) NH-W110, -C (O) NW111W112, -O-W113, -O (-W114-O) _t -H (t = 1, 2, 3, 4, 5), -O (-W115-O) _t -W116 (t = 1, 2, 3, 4, 5), -OC (O) -W117, -OC (O) -O-W118, -OC (O) -NHW119, -O-C (O)- NW120W121, -OP (O) (OW122) (OW123), -OSi (W124) (W125) (W126), -OS (O ₂ ) -W127, -NHC (O) -W128, -NW129C (O) -W130, -NH-C (O) -O-W131, -NH-C (O) -NH-W132, -NH-C (O ) -NW133W134, -NW135-C (O) -O-W136, -NW137-C (O) -NH-W138, -NW139-C (O) -NW140W141, -NHS (O ₂ ) -W142, -NW143S (O ₂ ) -W144, -S-W145, -S (O) -W146, -S (O ₂ ) -W147, -S (O ₂ ) NH-W148, -S (O ₂ ) NW149W150, -S (O ₂ ) O-W151, -P (O) (OW152) (OW153), -Si (W154) (W155) (W156) ";
At that time, W105, W106, W107, W108, W109, W110, W111, W112, W113, W114, W115, W116, W117, W118, W119, W120, W121, W122, W123, W124, W125, W126, W127, W128 , W129, W130, W131, W132, W133, W134, W135, W136, W137, W138, W139, W140, W141, W142, W143, W144, W145, W146, W147, W148, W149, W150, W151, W152, W153 , W154, W155, W156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W111, W112 and / or W120, W121 and / or W133, W134 and / or W140, W141 and / or W149, W150 may be taken together to form a “heterocyclyl”;
Or
One or both radicals Z3, Z4 of the radicals Z3, Z4 are independent of each other ₉ ~ C ₃₀ -Alkyl ";
At that time, "C ₉ ~ C ₃₀ “Alkyl” is optionally substituted by at least one substituent, independently of one another, selected from the group consisting of the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW157, -NW158W159, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W160, -C (O) O-W161, -C (O) NH-W162, -C (O) NW163W164, -O-W165, -O (-W166-O) _u -H (u = 1, 2, 3, 4, 5), -O (-W167-O) _u -W168 (u = 1, 2, 3, 4, 5), -OC (O) -W169, -OC (O) -O-W170, -OC (O) -NHW171, -O-C (O)- NW172W173, -OP (O) (OW174) (OW175), -OSi (W176) (W177) (W178), -OS (O ₂ ) -W179, -NHC (O) -W180, -NW181C (O) -W182, -NH-C (O) -O-W183, -NH-C (O) -NH-W184, -NH-C (O ) -NW185W186, -NW187-C (O) -O-W188, -NW189-C (O) -NH-W190, -NW191-C (O) -NW192W193, -NHS (O ₂ ) -W194, -NW195S (O ₂ ) -W196, -S-W197, -S (O) -W198, -S (O ₂ ) -W199, -S (O ₂ ) NH-W200, -S (O ₂ ) NW201W202, -S (O ₂ ) O-W203, -P (O) (OW204) (OW205), -Si (W206) (W207) (W208) ";
At that time, W157, W158, W159, W160, W161, W162, W163, W164, W165, W166, W167, W168, W169, W170, W171, W172, W173, W174, W175, W176, W177, W178, W179, W180 W181, W182, W183, W184, W185, W186, W187, W188, W189, W190, W191, W192, W193, W194, W195, W196, W197, W198, W199, W200, W201, W202, W203, W204, W205 , W206, W207, W208 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W163, W164 and / or W172, W173 and / or W185, W186 and / or W192, W193 and / or W201, W202 may be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW209, -NW210W211, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W212, -C (O) O-W213, -C (O) NH-W214, -C (O) NW215W216, -O-W217, -O (-W218-O) _v -H (v = 1, 2, 3, 4, 5), -O (-W219-O) _v -W220 (v = 1, 2, 3, 4, 5), -OC (O) -W221, -OC (O) -O-W222, -OC (O) -NHW223, -O-C (O)- NW224W225, -OP (O) (OW226) (OW227), -OSi (W228) (W229) (W230), -OS (O ₂ ) -W231, -NHC (O) -W232, -NW233C (O) -W234, -NH-C (O) -O-W235, -NH-C (O) -NH-W236, -NH-C (O ) -NW237W238, -NW239-C (O) -O-W240, -NW241-C (O) -NH-W242, -NW243-C (O) -NW244W245, -NHS (O ₂ ) -W246, -NW247S (O ₂ ) -W248, -S-W249, -S (O) -W250, -S (O ₂ ) -W251, -S (O ₂ ) NH-W252, -S (O ₂ ) NW253W254, -S (O ₂ ) O-W255, -P (O) (OW256) (OW257), -Si (W258) (W259) (W260) ";
At that time, W209, W210, W211, W212, W213, W214, W215, W216, W217, W218, W219, W220, W221, W222, W223, W224, W225, W226, W227, W228, W229, W230, W231, W232 , W233, W234, W235, W236, W237, W238, W239, W240, W241, W242, W243, W244, W245, W246, W247, W248, W249, W250, W251, W252, W253, W254, W255, W256, 255 , W258, W259, W260 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from W215, W216 and / or W224, W225 and / or Or W237, W238 and / or W244, W245 and / or W253, W254 may each be taken together to form a "heterocyclyl";
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(B) hydrogen;
(C) halogen, F, Cl, Br, I;
(D) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW457, -NW458W459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W460, -C (O) O-W461, -C (O) NH-W462, -C (O) NW463W464, -O-W465, -O (-W466-O) _x -H (x = 1, 2, 3, 4, 5), -O (-W467-O) _x -W468 (x = 1, 2, 3, 4, 5), -OC (O) -W469, -OC (O) -O-W470, -OC (O) -NHW471, -O-C (O)- NW472W473, -OP (O) (OW474) (OW475), -OSi (W476) (W477) (W478), -OS (O ₂ ) -W479, -NHC (O) -W480, -NW481C (O) -W482, -NH-C (O) -O-W483, -NH-C (O) -NH-W484, -NH-C (O ) -NW485W486, -NW487-C (O) -O-W488, -NW489-C (O) -NH-W490, -NW491-C (O) -NW492W493, -NHS (O ₂ ) -W494, -NW495S (O ₂ ) -W496, -S-W497, -S (O) -W498, -S (O ₂ ) -W499, -S (O ₂ ) NH-W500, -S (O ₂ ) NW501W502, -S (O ₂ ) O-W503, -P (O) (OW504) (OW505), -Si (W506) (W507) (W508) ";
At that time, W457, W458, W459, W460, W461, W462, W463, W464, W465, W466, W467, W468, W469, W470, W471, W472, W473, W474, W475, W476, W477, W478, W479, W480 W481, W482, W483, W484, W485, W486, W487, W488, W489, W490, W491, W492, W493, W494, W495, W496, W497, W498, W499, W500, W501, W502, W503, W504, 50 , W506, W507, W508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W463, W464 and / or W472, W473 and / or W485, W486 and / or W492, W493 and / or W501, W502 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW509, -NW510W511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W512, -C (O) O-W513, -C (O) NH-W514, -C (O) NW515W516, -O-W517, -O (-W518-O) _y -H (y = 1, 2, 3, 4, 5), -O (-W519-O) _y -W520 (y = 1, 2, 3, 4, 5), -OC (O) -W521, -OC (O) -O-W522, -OC (O) -NHW523, -O-C (O)- NW524W525, -OP (O) (OW526) (OW527), -OSi (W528) (W529) (W530), -OS (O ₂ ) -W531, -NHC (O) -W532, -NW533C (O) -W534, -NH-C (O) -O-W535, -NH-C (O) -NH-W536, -NH-C (O ) -NW537W538, -NW539-C (O) -O-W540, -NW541-C (O) -NH-W542, -NW543-C (O) -NW544W545, -NHS (O ₂ ) -W546, -NW547S (O ₂ ) -W548, -S-W549, -S (O) -W550, -S (O ₂ ) -W551, -S (O ₂ ) NH-W552, -S (O ₂ ) NW553W554, -S (O ₂ ) O-W555, -P (O) (OW556) (OW557), -Si (W558) (W559) (W560) ";
At that time, W509, W510, W511, W512, W513, W514, W515, W516, W517, W518, W519, W520, W521, W522, W523, W524, W525, W526, W527, W528, W529, W530, W531, W532 , W533, W534, W535, W536, W537, W538, W539, W540, W541, W542, W543, W544, W545, W546, W547, W548, W549, W550, W551, W552, W553, W554, W555, W556, W555, W556 , W558, W559, W560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W515, W516 and / or W524, W525 and / or W537, W538 and / or W544, W545 and / or W553, W554 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW561, -NW562W563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W564, -C (O) O-W565, -C (O) NH-W566, -C (O) NW567W568, -O-W569, -O (-W570-O) _z -H (z = 1, 2, 3, 4, 5), -O (-W571-O) _z -W572 (z = 1, 2, 3, 4, 5), -OC (O) -W573, -OC (O) -O-W574, -OC (O) -NHW575, -O-C (O)- NW576W577, -OP (O) (OW578) (OW579), -OSi (W580) (W581) (W582), -OS (O ₂ ) -W583, -NHC (O) -W584, -NW585C (O) -W586, -NH-C (O) -O-W587, -NH-C (O) -NH-W588, -NH-C (O ) -NW589W590, -NW591-C (O) -O-W592, -NW593-C (O) -NH-W594, -NW595-C (O) -NW596W597, -NHS (O ₂ ) -W598, -NW599S (O ₂ ) -W600, -S-W601, -S (O) -W602, -S (O ₂ ) -W603, -S (O ₂ ) NH-W604, -S (O ₂ ) NW605W606, -S (O ₂ ) O-W607, -P (O) (OW608) (OW609), -Si (W610) (W611) (W612) ";
At that time, W561, W562, W563, W564, W565, W566, W567, W568, W569, W570, W571, W572, W573, W574, W575, W576, W577, W578, W579, W580, W581, W582, W583, W584 W585, W586, W587, W588, W589, W590, W591, W592, W593, W594, W595, W596, W597, W598, W599, W600, W601, W602, W603, W604, W605, W606, W607, W608, W608 , W610, W611, W612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W567, W568 and / or W576, W577 and / or W589, W590 and / or W596, W597 and / or W605, W606 may each be taken together to form a “heterocyclyl”;
(E) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW613, -NW614W615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W616, -C (O) O-W617, -C (O) NH-W618, -C (O) NW619W620, -O-W621, -O (-W622-O) _a -H (a = 1, 2, 3, 4, 5), -O (-W623-O) _a -W624 (a = 1, 2, 3, 4, 5), -OC (O) -W625, -OC (O) -O-W626, -OC (O) -NHW627, -O-C (O)- NW628W629, -OP (O) (OW630) (OW631), -OSi (W632) (W633) (W634), -OS (O ₂ ) -W635, -NHC (O) -W636, -NW637C (O) -W638, -NH-C (O) -O-W639, -NH-C (O) -NH-W640, -NH-C (O ) -NW641W642, -NW643-C (O) -O-W644, -NW645-C (O) -NH-W646, -NW647-C (O) -NW648W649, -NHS (O ₂ ) -W650, -NW651S (O ₂ ) -W652, -S-W653, -S (O) -W654, -S (O ₂ ) -W655, -S (O ₂ ) NH-W656, -S (O ₂ ) NW657W658, -S (O ₂ ) O-W659, -P (O) (OW660) (OW661), -Si (W662) (W663) (W664) ";
In that case, W613, W614, W615, W616, W617, W618, W619, W620, W621, W622, W623, W624, W625, W626, W627, W628, W629, W630, W631, W632, W633, W634, W635, W636, W636 , W637, W638, W639, W640, W641, W642, W643, W644, W645, W646, W647, W648, W649, W650, W651, W652, W653, W654, W655, W656, W657, W658, W659, W660, W659, W660 , W662, W663, W664 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W619, W620 and / or W628, W629 and / or W641, W642 and / or W648, W649 and / or W657, W658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW665, -NW666W667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W668, -C (O) O-W669, -C (O) NH-W670, -C (O) NW671W672, -O-W673, -O (-W674-O) _b -H (b = 1, 2, 3, 4, 5), -O (-W675-O) _b -W676 (b = 1, 2, 3, 4, 5), -OC (O) -W677, -OC (O) -O-W678, -OC (O) -NHW679, -O-C (O)- NW680W681, -OP (O) (OW682) (OW683), -OSi (W684) (W685) (W686), -OS (O ₂ ) -W687, -NHC (O) -W688, -NW689C (O) -W690, -NH-C (O) -O-W691, -NH-C (O) -NH-W692, -NH-C (O ) -NW693W694, -NW695-C (O) -O-W696, -NW697-C (O) -NH-W698, -NW699-C (O) -NW700W701, -NHS (O ₂ ) -W702, -NW703S (O ₂ ) -W704, -S-W705, -S (O) -W706, -S (O ₂ ) -W707, -S (O ₂ ) NH-W708, -S (O ₂ ) NW709W710, -S (O ₂ ) O-W711, -P (O) (OW712) (OW713), -Si (W714) (W715) (W716) ";
At that time, W665, W666, W667, W668, W669, W670, W671, W672, W673, W674, W675, W676, W677, W678, W679, W680, W681, W682, W683, W684, W685, W686, W687, W688 , W689, W690, W691, W692, W693, W694, W695, W696, W697, W698, W699, W700, W701, W702, W703, W704, W705, W706, W707, W708, W709, W710, W711, W712, W711 , W714, W715, W716 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W671, W672 and / or W680, W681 and / or W693, W694 and / or W700, W701 and / or W709, W710 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW717, -NW718W719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W720, -C (O) O-W721, -C (O) NH-W722, -C (O) NW723W724, -O-W725, -O (-W726-O) _c -H (c = 1, 2, 3, 4, 5), -O (-W727-O) _c -W728 (c = 1, 2, 3, 4, 5), -OC (O) -W729, -OC (O) -O-W730, -OC (O) -NHW731, -O-C (O)- NW732W733, -OP (O) (OW734) (OW735), -OSi (W736) (W737) (W738), -OS (O ₂ ) -W739, -NHC (O) -W740, -NW741C (O) -W742, -NH-C (O) -O-W743, -NH-C (O) -NH-W744, -NH-C (O ) -NW745W746, -NW747-C (O) -O-W748, -NW749-C (O) -NH-W750, -NW751-C (O) -NW752W753, -NHS (O ₂ ) -W754, -NW755S (O ₂ ) -W756, -S-W757, -S (O) -W758, -S (O ₂ ) -W759, -S (O ₂ ) NH-W760, -S (O ₂ ) NW761W762, -S (O ₂ ) O-W763, -P (O) (OW764) (OW765), -Si (W766) (W767) (W768) ";
At that time, W717, W718, W719, W720, W721, W722, W723, W724, W725, W726, W727, W728, W729, W730, W731, W732, W733, W734, W735, W736, W737, W738, W739, W7 W741, W742, W743, W744, W745, W746, W747, W748, W749, W750, W751, W752, W753, W754, W755, W756, W757, W758, W759, W760, W761, W762, W763, W764 , W766, W767, W768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W723, W724 and / or W732, W733 and / or W745, W746 and / or W752, W753 and / or W761, W762 can each be taken together to form a "heterocyclyl";
(F) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW769, -NW770W771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W772, -C (O) O-W773, -C (O) NH-W774, -C (O) NW775W776, -O-W777, -O (-W778-O). _d -H (d = 1, 2, 3, 4, 5), -O (-W779-O) _d -W780 (d = 1, 2, 3, 4, 5), -OC (O) -W781, -OC (O) -O-W782, -OC (O) -NHW783, -O-C (O)- NW784W785, -OP (O) (OW786) (OW787), -OSi (W788) (W789) (W790), -OS (O ₂ ) -W791, -NHC (O) -W792, -NW793C (O) -W794, -NH-C (O) -O-W795, -NH-C (O) -NH-W796, -NH-C (O ) -NW797W798, -NW799-C (O) -O-W800, -NW801-C (O) -NH-W802, -NW803-C (O) -NW804W805, -NHS (O ₂ ) -W806, -NW807S (O ₂ ) -W808, -S-W809, -S (O) -W810, -S (O ₂ ) -W811, -S (O ₂ ) NH-W812, -S (O ₂ ) NW813W814, -S (O ₂ ) O-W815, -P (O) (OW816) (OW817), -Si (W818) (W819) (W820) ";
At that time, W769, W770, W771, W772, W773, W774, W775, W776, W777, W778, W779, W780, W781, W782, W783, W784, W785, W786, W787, W788, W789, W790, W791, W79 , W793, W794, W795, W796, W797, W798, W799, W800, W801, W802, W803, W804, W805, W806, W807, W808, W809, W810, W811, W812, W813, W814, W815, W816, , W818, W819, W820 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W775, W776 and / or W784, W785 and / or W797, W798 and / or W804, W805 and / or W813, W814 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW821, -NW822W823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W824, -C (O) O-W825, -C (O) NH-W826, -C (O) NW827W828, -O-W829, -O (-W830-O) _e -H (e = 1, 2, 3, 4, 5), -O (-W831-O) _e -W832 (e = 1, 2, 3, 4, 5), -OC (O) -W833, -OC (O) -O-W834, -OC (O) -NHW835, -O-C (O)- NW836W837, -OP (O) (OW838) (OW839), -OSi (W840) (W841) (W842), -OS (O ₂ ) -W843, -NHC (O) -W844, -NW845C (O) -W846, -NH-C (O) -O-W847, -NH-C (O) -NH-W848, -NH-C (O ) -NW849W850, -NW851-C (O) -O-W852, -NW853-C (O) -NH-W854, -NW855-C (O) -NW856W857, -NHS (O ₂ ) -W858, -NW859S (O ₂ ) -W860, -S-W861, -S (O) -W862, -S (O ₂ ) -W863, -S (O ₂ ) NH-W864, -S (O ₂ ) NW865W866, -S (O ₂ ) O-W867, -P (O) (OW868) (OW869), -Si (W870) (W871) (W872) ";
At that time, W821, W822, W823, W824, W825, W826, W827, W828, W829, W830, W831, W832, W833, W834, W835, W836, W837, W838, W839, W840, W841, W842, W843, W84 W845, W846, W847, W848, W849, W850, W851, W852, W853, W854, W855, W856, W857, W858, W859, W860, W861, W862, W863, W864, W865, W866, W867, W868, W867, W868 , W870, W871, W872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W827, W828 and / or W836, W837 and / or W849, W850 and / or W856, W857 and / or W865, W866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW873, -NW874W875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W876, -C (O) O-W877, -C (O) NH-W878, -C (O) NW879W880, -O-W881, -O (-W882-O) _f -H (f = 1, 2, 3, 4, 5), -O (-W883-O) _f -W884 (f = 1, 2, 3, 4, 5), -OC (O) -W885, -OC (O) -O-W886, -OC (O) -NHW887, -O-C (O)- NW888W889, -OP (O) (OW890) (OW891), -OSi (W892) (W893) (W894), -OS (O ₂ ) -W895, -NHC (O) -W896, -NW897C (O) -W898, -NH-C (O) -O-W899, -NH-C (O) -NH-W900, -NH-C (O ) -NW901W902, -NW903-C (O) -O-W904, -NW905-C (O) -NH-W906, -NW907-C (O) -NW908W909, -NHS (O ₂ ) -W910, -NW911S (O ₂ ) -W912, -S-W913, -S (O) -W914, -S (O ₂ ) -W915, -S (O ₂ ) NH-W916, -S (O ₂ ) NW917W918, -S (O ₂ ) O-W919, -P (O) (OW920) (OW921), -Si (W922) (W923) (W924) ";
In that case, W873, W874, W875, W876, W877, W878, W879, W880, W881, W882, W883, W884, W885, W886, W887, W888, W889, W890, W891, W892, W893, W894, W895, W896 W897, W898, W899, W900, W901, W902, W903, W904, W905, W906, W907, W908, W909, W910, W911, W912, W913, W914, W915, W916, W917, W918, W919, W920, W921, W920 , W922, W923, W924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W879, W880 and / or W888, W889 and / or W901, W902 and / or W908, W909 and / or W917, W918 may each be taken together to form a “heterocyclyl”;
(G) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW925, -NW926W927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W928, -C (O) O-W929, -C (O) NH-W930, -C (O) NW931W932, -O-W933, -O (-W934-O) _g -H (g = 1, 2, 3, 4, 5), -O (-W935-O) _g -W936 (g = 1, 2, 3, 4, 5), -OC (O) -W937, -OC (O) -O-W938, -OC (O) -NHW939, -O-C (O)- NW940W941, -OP (O) (OW942) (OW943), -OSi (W944) (W945) (W946), -OS (O ₂ ) -W947, -NHC (O) -W948, -NW949C (O) -W950, -NH-C (O) -O-W951, -NH-C (O) -NH-W952, -NH-C (O ) -NW953W954, -NW955-C (O) -O-W956, -NW957-C (O) -NH-W958, -NW959-C (O) -NW960W961, -NHS (O ₂ ) -W962, -NW963S (O ₂ ) -W964, -S-W965, -S (O) -W966, -S (O ₂ ) -W967, -S (O ₂ ) NH-W968, -S (O ₂ ) NW969W970, -S (O ₂ ) O-W971, -P (O) (OW972) (OW973), -Si (W974) (W975) (W976) ";
At that time, W925, W926, W927, W928, W929, W930, W931, W932, W933, W934, W935, W936, W937, W938, W939, W940, W941, W942, W943, W944, W945, W946, W947, W948 , W949, W950, W951, W952, W953, W954, W955, W956, W957, W958, W959, W960, W961, W962, W963, W964, W965, W966, W967, W968, W969, W970, W971, W972 , W974, W975, W976 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W931, W932 and / or W940, W941 and / or W953, W954 and / or W960, W961 and / or W969, W970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW977, -NW978W979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W980, -C (O) O-W981, -C (O) NH-W982, -C (O) NW983W984, -O-W985, -O (-W986-O) _h -H (h = 1, 2, 3, 4, 5), -O (-W987-O) _h -W988 (h = 1, 2, 3, 4, 5), -OC (O) -W989, -OC (O) -O-W990, -OC (O) -NHW991, -O-C (O)- NW992W993, -OP (O) (OW994) (OW995), -OSi (W996) (W997) (W998), -OS (O ₂ ) -W999, -NHC (O) -W1000, -NW1001C (O) -W1002, -NH-C (O) -O-W1003, -NH-C (O) -NH-W1004, -NH-C (O ) -NW1005W1006, -NW1007-C (O) -O-W1008, -NW1009-C (O) -NH-W1010, -NW1011-C (O) -NW1012W1013, -NHS (O ₂ ) -W1014, -NW1015S (O ₂ ) -W1016, -S-W1017, -S (O) -W1018, -S (O ₂ ) -W1019, -S (O ₂ ) NH-W1020, -S (O ₂ ) NW1021W1022, -S (O ₂ ) O-W1023, -P (O) (OW1024) (OW1025), -Si (W1026) (W1027) (W1028) ";
In that case, W977, W978, W979, W980, W981, W982, W983, W984, W985, W986, W987, W988, W989, W990, W991, W992, W993, W994, W995, W996, W997, W998, W999, W1000 , W1001, W1002, W1003, W1004, W1005, W1006, W1007, W1008, W1009, W1010, W1011, W1012, W1013, W1014, W1015, W1016, W1017, W1018, W1019, W1020, W1021, W1022, W1023, W1024 , W1026, W1027, W1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W983, W984 and / or W992, W993 and / or W1005, W1006 and / or W1012, W1013 and / or W1021, W1022 may each be taken together to form a "heterocyclyl";
(H) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1029, -NW1030W1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1032, -C (O) O-W1033, -C (O) NH-W1034, -C (O) NW1035W1036, -O-W1037, -O (-W1038-O) _i -H (i = 1, 2, 3, 4, 5), -O (-W1039-O) _i -W1040 (i = 1, 2, 3, 4, 5), -OC (O) -W1041, -OC (O) -O-W1042, -OC (O) -NHW1043, -O-C (O)- NW1044W1045, -OP (O) (OW1046) (OW1047), -OSi (W1048) (W1049) (W1050), -OS (O ₂ ) -W1051, -NHC (O) -W1052, -NW1053C (O) -W1054, -NH-C (O) -O-W1055, -NH-C (O) -NH-W1056, -NH-C (O ) -NW1057W1058, -NW1059-C (O) -O-W1060, -NW1061-C (O) -NH-W1062, -NW1063-C (O) -NW1064W1065, -NHS (O ₂ ) -W1066, -NW1067S (O ₂ ) -W1068, -S-W1069, -S (O) -W1070, -S (O ₂ ) -W1071, -S (O ₂ ) NH-W1072, -S (O ₂ ) NW1073W1074, -S (O ₂ ) O-W1075, -P (O) (OW1076) (OW1077), -Si (W1078) (W1079) (W1080) ";
At that time, W1029, W1030, W1031, W1032, W1033, W1034, W1035, W1036, W1037, W1038, W1039, W1040, W1041, W1042, W1043, W1044, W1045, W1046, W1047, W1048, W1049, W1050, W1051, W1052, . , W1078, W1079, W1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1035, W1036 and / or W1044, W1045 and / or W1057, W1058 and / or W1064, W1065 and / or W1073, W1074 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1081, -NW1082W1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1084, -C (O) O-W1085, -C (O) NH-W1086, -C (O) NW1087W1088, -O-W1089, -O (-W1090-O) _j -H (j = 1, 2, 3, 4, 5), -O (-W1091-O) _j -W1092 (j = 1, 2, 3, 4, 5), -OC (O) -W1093, -OC (O) -O-W1094, -OC (O) -NHW1095, -O-C (O)- NW1096W1097, -OP (O) (OW1098) (OW1099), -OSi (W1100) (W1101) (W1102), -OS (O ₂ ) -W1103, -NHC (O) -W1104, -NW1105C (O) -W1106, -NH-C (O) -O-W1107, -NH-C (O) -NH-W1108, -NH-C (O ) -NW1109W1110, -NW1111-C (O) -O-W1112, -NW1113-C (O) -NH-W1114, -NW1115-C (O) -NW1116W1117, -NHS (O ₂ ) -W1118, -NW1119S (O ₂ ) -W1120, -S-W1121, -S (O) -W1122, -S (O ₂ ) -W1123, -S (O ₂ ) NH-W1124, -S (O ₂ ) NW1125W1126, -S (O ₂ ) O-W1127, -P (O) (OW1128) (OW1129), -Si (W1130) (W1131) (W1132) ";
At that time, W1081, W1082, W1083, W1084, W1085, W1086, W1087, W1088, W1089, W1090, W1091, W1092, W1093, W1094, W1095, W1096, W1097, W1098, W1099, W1100, W1101, W1102, W1103, W1104 W1105, W1106, W1107, W1108, W1109, W1110, W1111, W1112, W1113, W1114, W1115, W1116, W1117, W1118, W1119, W1120, W1121, W1122, W1123, W1124, W1125, W1126, W1127, W1128, W1127, W1128 , W1130, W1131, W1132, independently of one another, are “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1087, W1088 and / or W1096, W1097 and / or W1109, W1110 and / or W1116, W1117 and / or W1125, W1126 may each be taken together to form a “heterocyclyl”;
(J) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -W1133, -C (O) O-W1134, -C (O)- NW1135W1136, -S (O ₂ ) -W1137, -S (O ₂ ) O-W1138 ";
In this case, W1133, W1134, W1135, W1136, W1137, and W1138 are independent of each other as “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, W1135, W1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1139, -NW1140W1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1142, -C (O) O-W1143, -C (O) NH-W1144, -C (O) NW1145W1146, -O-W1147, -O (-W1148-O) _k -H (k = 1, 2, 3, 4, 5), -O (-W1149-O) _k -W1150 (k = 1, 2, 3, 4, 5), -OC (O) -W1151, -OC (O) -O-W1152, -OC (O) -NHW1153, -O-C (O)- NW1154W1155, -OP (O) (OW1156) (OW1157), -OSi (W1158) (W1159) (W1160), -OS (O ₂ ) -W1161, -NHC (O) -W1162, -NW1163C (O) -W1164, -NH-C (O) -O-W1165, -NH-C (O) -NH-W1166, -NH-C (O ) -NW1167W1168, -NW1169-C (O) -O-W1170, -NW1171-C (O) -NH-W1172, -NW1173-C (O) -NW1174W1175, -NHS (O ₂ ) -W1176, -NW1177S (O ₂ ) -W1178, -S-W1179, -S (O) -W1180, -S (O ₂ ) -W1181, -S (O ₂ ) NH-W1182, -S (O ₂ ) NW1183W1184, -S (O ₂ ) O-W1185, -P (O) (OW1186) (OW1187), -Si (W1188) (W1189) (W1190) ";
In that case, W1139, W1140, W1141, W1142, W1143, W1144, W1145, W1146, W1147, W1148, W1149, W1150, W1151, W1152, W1153, W1154, W1155, W1156, W1157, W1158, W1159, W1160, W1161, W1162 W1163, W1164, W1165, W1166, W1167, W1168, W1169, W1170, W1171, W1172, W1173, W1174, W1175, W1176, W1177, W1178, W1179, W1180, W1181, W1182, W1183, W1184, W1185, W1186, W1185, W1186 , W1188, W1189, W1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1145, W1146 and / or W1154, W1155 and / or W 1167, W 1168 and / or W 1174, W 1175 and / or W 1183, W 1184 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHW1191, -NW1192W1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -W1194, -C (O) O-W1195, -C (O) NH-W1196, -C (O) NW1197W1198, -O-W1199, -O (-W1200-O). _l -H (l = 1, 2, 3, 4, 5), -O (-W1201-O) _l -W1202 (l = 1, 2, 3, 4, 5), -OC (O) -W1203, -OC (O) -O-W1204, -OC (O) -NHW1205, -O-C (O)- NW1206W1207, -OP (O) (OW1208) (OW1209), -OSi (W1210) (W1211) (W1212), -OS (O ₂ ) -W1213, -NHC (O) -W1214, -NW1215C (O) -W1216, -NH-C (O) -O-W1217, -NH-C (O) -NH-W1218, -NH-C (O ) -NW1219W1220, -NW1221-C (O) -O-W1222, -NW1223-C (O) -NH-W1224, -NW1225-C (O) -NW1226W1227, -NHS (O ₂ ) -W1228, -NW1229S (O ₂ ) -W1230, -S-W1231, -S (O) -W1232, -S (O ₂ ) -W1233, -S (O ₂ ) NH-W1234, -S (O ₂ ) NW1235W1236, -S (O ₂ ) O-W1237, -P (O) (OW1238) (OW1239), -Si (W1240) (W1241) (W1242) ";
At that time, W1191, W1192, W1193, W1194, W1195, W1196, W1197, W1198, W1199, W1200, W1201, W1202, W1203, W1204, W1205, W1206, W1207, W1208, W1209, W1210, W1211, W1212, W1212, W1212 W1215, W1216, W1217, W1218, W1219, W1220, W1221, W1222, W1223, W1224, W1225, W1226, W1227, W1228, W1229, W1230, W1231, W1232, W1233, W1234, W1235, W1236, W1237, W1238 , W1240, W1241, W1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally W1197, W1198 and / or W1206, W1207 and / or W1219, W1220 and / or W1226, W1227 and / or W1235, W1236 may each be taken together to form a “heterocyclyl”;
Or
(D)
One or both groups Z3, Z4 of the groups Z3, Z4, independently of one another, are selected from the group consisting of:
(1) "-NZ10Z11, -OZ12, -SZ13";
In this case, one or both groups Z10, Z11 and groups Z12, Z13 of the groups Z10, Z11 are selected, independently of one another, from the group consisting of:
(A) "hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl";
Provided that both groups Z10, Z11 are not simultaneously hydrogen;
In addition, however, the group Z12 is not hydrogen;
Provided that the substituent of the substituent group (a) is further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other, when not being hydrogen. Is:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N _Three , -NH-cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NQ1Q2, -S- Cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -O-cycloalkyl , -O-cycloalkylalkyl, -O-arylalkyl, -O-heteroaryl, -O-heteroarylalkyl, -O-heterocyclyl, -O-heterocyclylalkyl, -O (-Q3-O) _p -Q4 (p = 1, 2, 3, 4, 5), -O (-Q5-O) _p -H (p = 1, 2, 3, 4, 5), -OP (O) (OQ6) (OQ7), -C (O) O-Q8, -C (O) NH ₂ , -C (O) NH-Q9, -C (O) NQ10Q11, -S (O ₂ ) -Q12, -P (O) (OH) ₂ , -P (O) (OQ13) (OQ14), -Si (Q15) (Q16) (Q17), -O-Si (Q18) (Q19) (Q20), -O-C (O) -O-Q21 , -O-C (O) -NH-Q22, -O-C (O) -NQ23Q24, -NH-C (O) -O-Q25, -NH-C (O) -NH-Q26, -NH- C (O) -NQ27Q28, -NQ29-C (O) -O-Q30, -NQ31-C (O) -NH-Q32, -NQ33-C (O) -NQ34Q35, -NQ36-S (O ₂ ) -Q37, -NH-S (O ₂ ) -Q38, -O-S (O ₂ ) -Q39, -NH-C (O) -Q40, -NQ41-C (O) -Q42, -C (O) -Q43, -OC (O) -Q44, -S (O) -Q45, -S (O ₂ ) -NHQ46, -S (O ₂ ) -NQ47Q48, -S (O ₂ ) -OQ49 ";
However, in addition, “—N (alkyl) ₂ "Is further substituted with at least one substituent selected from the following substituent group (ii);
At that time, Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8, Q9, Q10, Q11, Q12, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q20, Q21, Q22, Q23, Q24 Q25, Q26, Q27, Q28, Q29, Q30, Q31, Q32, Q33, Q34, Q35, Q36, Q37, Q38, Q39, Q40, Q41, Q42, Q43, Q44, Q45, Q46, Q47, Q48, Q49 Are independent of each other, "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from Q10, Q11 and / or Q23, Q24 and / or Or Q27, Q28 and / or Q34, Q35 and / or Q47, Q48 may each be taken together to form a "heterocyclyl";
In that case, depending on the circumstances, the substituents of the substituent group (a) and / or the substituent group (i), independently of one another, are the same or different and are selected from the group consisting of: It may be further substituted by a group:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ50, -NQ51Q52, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q53, -C (O) O-Q54, -C (O) NH-Q55, -C (O) NQ56Q57, -O-Q58, -O (-Q59-O) _r -H (r = 1, 2, 3, 4, 5), -O (-Q60-O) _r -Q61 (r = 1, 2, 3, 4, 5), -OC (O) -Q62, -OC (O) -O-Q63, -OC (O) -NHQ64, -O-C (O)- NQ65Q66, -OP (O) (OQ67) (OQ68), -OSi (Q69) (Q70) (Q71), -OS (O ₂ ) -Q72, -NHC (O) -Q73, -NQ74C (O) -Q75, -NH-C (O) -O-Q76, -NH-C (O) -NH-Q77, -NH-C (O ) -NQ78Q79, -NQ80-C (O) -O-Q81, -NQ82-C (O) -NH-Q83, -NQ84-C (O) -NQ85Q86, -NHS (O ₂ ) -Q87, -NQ88S (O ₂ ) -Q89, -S-Q90, -S (O) -Q91, -S (O ₂ ) -Q92, -S (O ₂ ) NH-Q93, -S (O ₂ ) NQ94Q95, -S (O ₂ ) O-Q96, -P (O) (OQ97) (OQ98), -Si (Q99) (Q100) (Q101) ";
At that time, Q50, Q52, Q53, Q54, Q55, Q56, Q57, Q58, Q59, Q60, Q61, Q62, Q63, Q64, Q65, Q66, Q67, Q68, Q69, Q70, Q71, Q72, Q73, Q74 Q75, Q76, Q77, Q78, Q79, Q80, Q81, Q82, Q83, Q84, Q85, Q86, Q87, Q88, Q89, Q90, Q91, Q92, Q93, Q94, Q95, Q96, Q97, Q98, Q99 , Q100 and Q101 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q56, Q57 and / or Q65, Q66 and / or Q78, Q79 and / or Q85, Q86 and / or Q94, Q95 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ102, -NQ103Q104, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q105, -C (O) O-Q106, -C (O) NH-Q107, -C (O) NQ108Q109, -O-Q110, -O (-Q111-O) _s -H (s = 1, 2, 3, 4, 5), -O (-Q112-O) _s -Q113 (s = 1, 2, 3, 4, 5), -OC (O) -Q114, -OC (O) -O-Q115, -OC (O) -NHQ116, -O-C (O)- NQ117Q118, -OP (O) (OQ119) (OQ120), -OSi (Q121) (Q122) (Q123), -OS (O ₂ ) -Q124, -NHC (O) -Q125, -NQ126C (O) -Q127, -NH-C (O) -O-Q128, -NH-C (O) -NH-Q129, -NH-C (O ) -NQ130Q131, -NQ132-C (O) -O-Q133, -NQ134-C (O) -NH-Q135, -NQ136-C (O) -NQ137Q138, -NHS (O ₂ ) -Q139, -NQ140S (O ₂ ) -Q141, -S-Q142, -S (O) -Q143, -S (O ₂ ) -Q144, -S (O ₂ ) NH-Q145, -S (O ₂ ) NQ146Q147, -S (O ₂ ) O-Q148, -P (O) (OQ149) (OQ150), -Si (Q152) (Q152) (Q153) ";
At that time, Q102, Q103, Q104, Q105, Q106, Q107, Q108, Q109, Q110, Q111, Q112, Q113, Q114, Q115, Q116, Q117, Q118, Q119, Q120, Q121, Q122, Q123, Q124, Q125 Q126, Q127, Q128, Q129, Q130, Q131, Q132, Q133, Q134, Q135, Q136, Q137, Q138, Q139, Q140, Q141, Q142, Q143, Q144, Q145, Q146, Q147, Q148, Q149, Q150 , Q151, Q152, Q153 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q108, Q109 and / or Q117, Q118 and / or Q130, Q131 and / or Q137, Q138 and / or Q146, Q147 may each be taken together to form a “heterocyclyl”;
(B) "C ₉ ~ C ₃₀ -Alkyl, -C (O) -Q154, -C (O) O-Q155, -C (O) -NQ156Q157, -S (O ₂ ) -Q158, -S (O ₂ ) O-Q159 ";
In this case, Q154, Q155, Q156, Q157, Q158, and Q159 are independent of each other as “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, Q156, Q157 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (b) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ160, -NQ161Q162, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q163, -C (O) O-Q164, -C (O) NH-Q165, -C (O) NQ166Q167, -O-Q168, -O (-Q169-O) _t -H (t = 1, 2, 3, 4, 5), -O (-Q170-O) _t -Q171 (t = 1, 2, 3, 4, 5), -OC (O) -Q172, -OC (O) -O-Q173, -OC (O) -NHQ174, -O-C (O)- NQ175Q176, -OP (O) (OQ177) (OQ178), -OSi (Q179) (Q180) (Q181), -OS (O ₂ ) -Q182, -NHC (O) -Q183, -NQ184C (O) -Q185, -NH-C (O) -O-Q186, -NH-C (O) -NH-Q187, -NH-C (O ) -NQ188Q189, -NQ190-C (O) -O-Q191, -NQ192-C (O) -NH-Q193, -NQ194-C (O) -NQ195Q196, -NHS (O ₂ ) -Q197, -NQ198S (O ₂ ) -Q199, -S-Q200, -S (O) -Q201, -S (O ₂ ) -Q202, -S (O ₂ ) NH-Q203, -S (O ₂ ) NQ204Q205, -S (O ₂ ) O-Q206, -P (O) (OQ207) (OQ208), -Si (Q209) (Q210) (Q211) ";
At that time, Q160, Q161, Q162, Q163, Q164, Q165, Q166, Q167, Q168, Q169, Q170, Q171, Q172, Q173, Q174, Q175, Q176, Q177, Q178, Q179, Q180, Q181, Q182, Q183 Q184, Q185, Q186, Q187, Q188, Q189, Q190, Q191, Q192, Q193, Q194, Q195, Q196, Q197, Q198, Q199, Q200, Q201, Q202, Q203, Q204, Q205, Q206, Q207, Q208 , Q209, Q210, Q211 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q166, Q167 and / or Q175, Q176 and / or Q188, Q189 and / or Q195, Q196 and / or Q204, Q205 can be taken together to form a “heterocyclyl”;
In this case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ212, -NQ213Q214, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q215, -C (O) O-Q216, -C (O) NH-Q217, -C (O) NQ218Q219, -O-Q220, -O (-Q221-O) _u -H (u = 1, 2, 3, 4, 5), -O (-Q222-O) _u -Q223 (u = 1, 2, 3, 4, 5), -OC (O) -Q224, -OC (O) -O-Q225, -OC (O) -NHQ226, -O-C (O)- NQ227Q228, -OP (O) (OQ229) (OQ230), -OSi (Q231) (Q232) (Q233), -OS (O ₂ ) -Q234, -NHC (O) -Q235, -NQ236C (O) -Q237, -NH-C (O) -O-Q238, -NH-C (O) -NH-Q239, -NH-C (O ) -NQ240Q241, -NQ242-C (O) -O-Q243, -NQ244-C (O) -NH-Q245, -NQ246-C (O) -NQ247Q248, -NHS (O ₂ ) -Q249, -NQ250S (O ₂ ) -Q251, -S-Q252, -S (O) -Q253, -S (O ₂ ) -Q254, -S (O ₂ ) NH-Q255, -S (O ₂ ) NQ256Q257, -S (O ₂ ) O-Q258, -P (O) (OQ259) (OQ260), -Si (Q261) (Q262) (Q263) ";
At that time, Q212, Q213, Q214, Q215, Q216, Q217, Q218, Q219, Q220, Q221, Q222, Q223, Q224, Q225, Q226, Q227, Q228, Q229, Q230, Q231, Q232, Q233, Q234, Q235 Q236, Q237, Q238, Q239, Q240, Q241, Q242, Q243, Q244, Q245, Q246, Q247, Q248, Q249, Q250, Q251, Q252, Q253, Q254, Q255, Q256, Q257, Q258, Q259, 260 , Q261, Q262, Q263 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from Q218, Q219 and / or Q227, Q228 and / Or Q240, Q241 and / or Q247, Q248 and / or Q256, Q257 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ264, -NQ265Q266, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q267, -C (O) O-Q268, -C (O) NH-Q269, -C (O) NQ270Q271, -O-Q272, -O (-Q273-O) _v -H (v = 1, 2, 3, 4, 5), -O (-Q274-O) _v -Q275 (v = 1, 2, 3, 4, 5), -OC (O) -Q276, -OC (O) -O-Q277, -OC (O) -NHQ278, -O-C (O)- NQ279Q280, -OP (O) (OQ281) (OQ282), -OSi (Q283) (Q284) (Q285), -OS (O ₂ ) -Q286, -NHC (O) -Q287, -NQ288C (O) -Q289, -NH-C (O) -O-Q290, -NH-C (O) -NH-Q291, -NH-C (O ) -NQ292Q293, -NQ294-C (O) -O-Q295, -NQ296-C (O) -NH-Q297, -NQ298-C (O) -NQ299Q300, -NHS (O ₂ ) -Q301, -NQ302S (O ₂ ) -Q303, -S-Q304, -S (O) -Q305, -S (O ₂ ) -Q306, -S (O ₂ ) NH-Q307, -S (O ₂ ) NQ308Q309, -S (O ₂ ) O-Q310, -P (O) (OQ311) (OQ312), -Si (Q313) (Q314) (Q315) ";
At that time, Q264, Q265, Q266, Q267, Q268, Q269, Q270, Q271, Q272, Q273, Q274, Q275, Q276, Q277, Q278, Q279, Q280, Q281, Q282, Q283, Q284, Q286, Q287 Q288, Q289, Q290, Q291, Q292, Q293, Q294, Q295, Q296, Q297, Q298, Q299, Q300, Q301, Q302, Q303, Q304, Q305, Q306, Q307, Q308, Q309, Q310, Q311, Q312 , Q313, Q314, and Q315 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q270, Q271 and / or Q279, Q289 and / or Q292, Q293 and / or Q299, Q300 and / or Q308, Q309 can each be taken together to form a “heterocyclyl”;
as well as
One of the groups Z10, Z11 is, independently of one another, selected from the group consisting of: or neither of the groups Z10, Z11 is selected from the group consisting of:
(C) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -C (O) -Q316, -C (O) O-Q317, -C (O)- NQ318Q319, -S (O ₂ ) -Q320, -S (O ₂ ) O-Q321 ";
At that time, Q316, Q317, Q318, Q319, Q320, and Q321 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, Q318, Q319 together are" Heterocyclyl "can also be formed;
In this case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ322, -NQ323Q324, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q325, -C (O) O-Q326, -C (O) NH-Q327, -C (O) NQ328Q329, -O-Q330, -O (-Q331-O) _w -H (w = 1, 2, 3, 4, 5), -O (-Q332-O) _w -Q333 (w = 1, 2, 3, 4, 5), -OC (O) -Q334, -OC (O) -O-Q335, -OC (O) -NHQ336, -O-C (O)- NQ337Q338, -OP (O) (OQ339) (OQ340), -OSi (Q341) (Q342) (Q343), -OS (O ₂ ) -Q344, -NHC (O) -Q345, -NQ346C (O) -Q347, -NH-C (O) -O-Q348, -NH-C (O) -NH-Q349, -NH-C (O ) -NQ350Q351, -NQ352-C (O) -O-Q353, -NQ354-C (O) -NH-Q355, -NQ356-C (O) -NQ357Q358, -NHS (O ₂ ) -Q359, -NQ360S (O ₂ ) -Q361, -S-Q362, -S (O) -Q363, -S (O ₂ ) -Q364, -S (O ₂ ) NH-Q365, -S (O ₂ ) NQ366Q367, -S (O ₂ ) O-Q368, -P (O) (OQ369) (OQ370), -Si (Q371) (Q372) (Q373) ";
At that time, Q322, Q323, Q324, Q325, Q326, Q327, Q328, Q329, Q330, Q331, Q332, Q333, Q334, Q335, Q336, Q337, Q338, Q339, Q340, Q341, Q342, Q343, Q344, Q345 Q346, Q347, Q348, Q349, Q350, Q351, Q352, Q353, Q354, Q355, Q356, Q357, Q358, Q359, Q360, Q361, Q362, Q363, Q364, Q365, Q366, Q367, Q368, Q369 , Q371, Q372 and Q373 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q328, Q329 and / or Q337, Q338 and / or Q350, Q351 and / or Q357, Q358 and / or Q366, Q367 may be taken together to form a “heterocyclyl”;
In that case, the said substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other;
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ374, -NQ375Q376, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q377, -C (O) O-Q378, -C (O) NH-Q379, -C (O) NQ380Q381, -O-Q382, -O (-Q383-O) _x -H (x = 1, 2, 3, 4, 5), -O (-Q384-O) _x -Q385 (x = 1, 2, 3, 4, 5), -OC (O) -Q386, -OC (O) -O-Q387, -OC (O) -NHQ388, -O-C (O)- NQ389Q390, -OP (O) (OQ391) (OQ392), -OSi (Q393) (Q394) (Q395), -OS (O ₂ ) -Q396, -NHC (O) -Q397, -NQ398C (O) -Q399, -NH-C (O) -O-Q400, -NH-C (O) -NH-Q401, -NH-C (O ) -NQ402Q403, -NQ404-C (O) -O-Q405, -NQ406-C (O) -NH-Q407, -NQ408-C (O) -NQ409Q410, -NHS (O ₂ ) -Q411, -NQ412S (O ₂ ) -Q413, -S-Q414, -S (O) -Q415, -S (O ₂ ) -Q416, -S (O ₂ ) NH-Q417, -S (O ₂ ) NQ418Q419, -S (O ₂ ) O-Q420, -P (O) (OQ421) (OQ422), -Si (Q423) (Q424) (Q425) ";
At that time, Q374, Q375, Q376, Q377, Q378, Q379, Q380, Q381, Q382, Q383, Q384, Q385, Q386, Q387, Q388, Q389, Q390, Q391, Q392, Q393, Q394, Q395, Q395, Q395 Q398, Q399, Q400, Q401, Q402, Q403, Q404, Q405, Q406, Q407, Q408, Q409, Q410, Q411, Q412, Q413, Q414, Q415, Q416, Q417, Q418, Q419, Q420, Q421, Q422 , Q423, Q424, Q425 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q380, Q381 and / or Q389, Q390 and / or Q402, Q403 and / or Q409, Q410 and / or Q418, Q419 may be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ426, -NQ427Q428, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q429, -C (O) O-Q430, -C (O) NH-Q431, -C (O) NQ432Q433, -O-Q434, -O (-Q435-O) _y -H (y = 1, 2, 3, 4, 5), -O (-Q436-O) _y -Q437 (y = 1, 2, 3, 4, 5), -OC (O) -Q438, -OC (O) -O-Q439, -OC (O) -NHQ440, -O-C (O)- NQ441Q442, -OP (O) (OQ443) (OQ444), -OSi (Q445) (Q446) (Q447), -OS (O ₂ ) -Q448, -NHC (O) -Q449, -NQ450C (O) -Q451, -NH-C (O) -O-Q452, -NH-C (O) -NH-Q453, -NH-C (O ) -NQ454Q455, -NQ456a-C (O) -O-Q456b, -NQ456c-C (O) -NH-Q456d, -NQ456e-C (O) -NQ456fQ456g, -NHS (O ₂ ) -Q456h, -NQ456iS (O ₂ ) -Q456j, -S-Q456k, -S (O) -Q456l, -S (O ₂ ) -Q456m, -S (O ₂ ) NH-Q456n, -S (O ₂ ) NQ456oQ456p, -S (O ₂ ) O-Q456q, -P (O) (OQ456r) (OQ456s), -Si (Q456t) (Q456u) (Q456v) ";
At that time, Q426, Q427, Q428, Q429, Q430, Q431, Q432, Q433, Q434, Q435, Q436, Q437, Q438, Q439, Q440, Q441, Q442, Q443, Q444, Q445, Q446a, Q446a, Q446c, Q446c Q446e, Q446f, Q446g, Q446h, Q446i, Q446j, Q446k, Q446l, Q446m, Q446n, Q446o, Q446p, Q446q, Q446r, Q446s, Q446t, Q446u, Q446v are independent of each other. ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q432, Q433 and / or Q441, Q442 and / or Q454, Q455 and / or Q456f, Q456g and / or Q456o, Q456p can be taken together to form a "heterocyclyl";
as well as
One of the groups Z3, Z4, independently of one another, is selected from the group consisting of: or neither of the groups Z3, Z4 is selected from the group consisting of:
(D) hydrogen;
(E) halogen, F, Cl, Br, I;
(F) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ457, -NQ458Q459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q460, -C (O) O-Q461, -C (O) NH-Q462, -C (O) NQ463Q464, -O-Q465, -O (-Q466-O) _z -H (z = 1, 2, 3, 4, 5), -O (-Q467-O) _z -Q468 (z = 1, 2, 3, 4, 5), -OC (O) -Q469, -OC (O) -O-Q470, -OC (O) -NHQ471, -O-C (O)- NQ472Q473, -OP (O) (OQ474) (OQ475), -OSi (Q476) (Q477) (Q478), -OS (O ₂ ) -Q479, -NHC (O) -Q480, -NQ481C (O) -Q482, -NH-C (O) -O-Q483, -NH-C (O) -NH-Q484, -NH-C (O ) -NQ485Q486, -NQ487-C (O) -O-Q488, -NQ489-C (O) -NH-Q490, -NQ491-C (O) -NQ492Q493, -NHS (O ₂ ) -Q494, -NQ495S (O ₂ ) -Q496, -S-Q497, -S (O) -Q498, -S (O ₂ ) -Q499, -S (O ₂ ) NH-Q500, -S (O ₂ ) NQ501Q502, -S (O ₂ ) O-Q503, -P (O) (OQ504) (OQ505), -Si (Q506) (Q507) (Q508) ";
At that time, Q457, Q458, Q459, Q460, Q461, Q462, Q463, Q464, Q465, Q466, Q467, Q468, Q469, Q470, Q471, Q472, Q473, Q474, Q475, Q476, Q477, Q478, Q480 Q481, Q482, Q483, Q484, Q485, Q486, Q487, Q488, Q489, Q490, Q491, Q492, Q493, Q494, Q495, Q496, Q497, Q498, Q499, Q500, Q501, Q502, Q503, Q504 , Q506, Q507, Q508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q463, Q464 and / or Q472, Q473 and / or Q485, Q486 and / or Q492, Q493 and / or Q501, Q502 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ509, -NQ510Q511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q512, -C (O) O-Q513, -C (O) NH-Q514, -C (O) NQ515Q516, -O-Q517, -O (-Q518-O) _a -H (a = 1, 2, 3, 4, 5), -O (-Q519-O) _a -Q520 (a = 1, 2, 3, 4, 5), -OC (O) -Q521, -OC (O) -O-Q522, -OC (O) -NHQ523, -O-C (O)- NQ524Q525, -OP (O) (OQ526) (OQ527), -OSi (Q528) (Q529) (Q530), -OS (O ₂ ) -Q531, -NHC (O) -Q532, -NQ533C (O) -Q534, -NH-C (O) -O-Q535, -NH-C (O) -NH-Q536, -NH-C (O ) -NQ537Q538, -NQ539-C (O) -O-Q540, -NQ541-C (O) -NH-Q542, -NQ543-C (O) -NQ544Q545, -NHS (O ₂ ) -Q546, -NQ547S (O ₂ ) -Q548, -S-Q549, -S (O) -Q550, -S (O ₂ ) -Q551, -S (O ₂ ) NH-Q552, -S (O ₂ ) NQ553Q554, -S (O ₂ ) O-Q555, -P (O) (OQ556) (OQ557), -Si (Q558) (Q559) (Q560) ";
At that time, Q509, Q510, Q511, Q512, Q513, Q514, Q515, Q516, Q517, Q518, Q519, Q520, Q521, Q522, Q523, Q524, Q525, Q526, Q527, Q528, Q529, Q530, Q531, Q532 Q533, Q534, Q535, Q536, Q537, Q538, Q539, Q540, Q541, Q542, Q543, Q544, Q545, Q546, Q547, Q548, Q549, Q550, Q551, Q552, Q553, Q554, Q555, Q556 , Q558, Q559, Q560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q515, Q516 and / or Q524, Q525 and / or Q537, Q538 and / or Q544, Q545 and / or Q553, Q554 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ561, -NQ562Q563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q564, -C (O) O-Q565, -C (O) NH-Q566, -C (O) NQ567Q568, -O-Q569, -O (-Q570-O) _b -H (b = 1, 2, 3, 4, 5), -O (-Q571-O) _b -Q572 (b = 1, 2, 3, 4, 5), -OC (O) -Q573, -OC (O) -O-Q574, -OC (O) -NHQ575, -O-C (O)- NQ576Q577, -OP (O) (OQ578) (OQ579), -OSi (Q580) (Q581) (Q582), -OS (O ₂ ) -Q583, -NHC (O) -Q584, -NQ585C (O) -Q586, -NH-C (O) -O-Q587, -NH-C (O) -NH-Q588, -NH-C (O ) -NQ589Q590, -NQ591-C (O) -O-Q592, -NQ593-C (O) -NH-Q594, -NQ595-C (O) -NQ596Q597, -NHS (O ₂ ) -Q598, -NQ599S (O ₂ ) -Q600, -S-Q601, -S (O) -Q602, -S (O ₂ ) -Q603, -S (O ₂ ) NH-Q604, -S (O ₂ ) NQ605Q606, -S (O ₂ ) O-Q607, -P (O) (OQ608) (OQ609), -Si (Q610) (Q611) (Q612) ";
At that time, Q561, Q562, Q563, Q564, Q565, Q566, Q567, Q568, Q569, Q570, Q571, Q572, Q573, Q574, Q575, Q576, Q577, Q578, Q579, Q580, Q581, Q582, Q583 Q585, Q586, Q587, Q588, Q589, Q590, Q591, Q592, Q593, Q594, Q595, Q596, Q597, Q598, Q599, Q600, Q601, Q602, Q603, Q604, Q605, Q606, Q607, Q608 , Q610, Q611, Q612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q567, Q568 and / or Q576, Q577 and / or Q589, Q590 and / or Q596, Q597 and / or Q605, Q606 can each be taken together to form a "heterocyclyl";
(G) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ613, -NQ614Q615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q616, -C (O) O-Q617, -C (O) NH-Q618, -C (O) NQ619Q620, -O-Q621, -O (-Q622-O) _c -H (c = 1, 2, 3, 4, 5), -O (-Q623-O) _c -Q624 (c = 1, 2, 3, 4, 5), -OC (O) -Q625, -OC (O) -O-Q626, -OC (O) -NHQ627, -O-C (O)- NQ628Q629, -OP (O) (OQ630) (OQ631), -OSi (Q632) (Q633) (Q634), -OS (O ₂ ) -Q635, -NHC (O) -Q636, -NQ637C (O) -Q638, -NH-C (O) -O-Q639, -NH-C (O) -NH-Q640, -NH-C (O ) -NQ641Q642, -NQ643-C (O) -O-Q644, -NQ645-C (O) -NH-Q646, -NQ647-C (O) -NQ648Q649, -NHS (O ₂ ) -Q650, -NQ651S (O ₂ ) -Q652, -S-Q653, -S (O) -Q654, -S (O ₂ ) -Q655, -S (O ₂ ) NH-Q656, -S (O ₂ ) NQ657Q658, -S (O ₂ ) O-Q659, -P (O) (OQ660) (OQ661), -Si (Q662) (Q663) (Q664) ";
At that time, Q613, Q614, Q615, Q616, Q617, Q618, Q619, Q620, Q621, Q622, Q623, Q624, Q625, Q626, Q627, Q628, Q629, Q630, Q631, Q632, Q633, Q634, Q635, Q636 Q637, Q638, Q639, Q640, Q641, Q642, Q643, Q644, Q645, Q646, Q647, Q648, Q649, Q650, Q651, Q652, Q653, Q654, Q655, Q656, Q657, Q658, Q659, Q660 , Q662, Q663, Q664 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q619, Q620 and / or Q628, Q629 and / or Q641, Q642 and / or Q648, Q649 and / or Q657, Q658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ665, -NQ666Q667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q668, -C (O) O-Q669, -C (O) NH-Q670, -C (O) NQ671Q672, -O-Q673, -O (-Q674-O) _d -H (d = 1, 2, 3, 4, 5), -O (-Q675-O) _d -Q676 (d = 1, 2, 3, 4, 5), -OC (O) -Q677, -OC (O) -O-Q678, -OC (O) -NHQ679, -O-C (O)- NQ680Q681, -OP (O) (OQ682) (OQ683), -OSi (Q684) (Q685) (Q686), -OS (O ₂ ) -Q687, -NHC (O) -Q688, -NQ689C (O) -Q690, -NH-C (O) -O-Q691, -NH-C (O) -NH-Q692, -NH-C (O ) -NQ693Q694, -NQ695-C (O) -O-Q696, -NQ697-C (O) -NH-Q698, -NQ699-C (O) -NQ700Q701, -NHS (O ₂ ) -Q702, -NQ703S (O ₂ ) -Q704, -S-Q705, -S (O) -Q706, -S (O ₂ ) -Q707, -S (O ₂ ) NH-Q708, -S (O ₂ ) NQ709Q710, -S (O ₂ ) O-Q711, -P (O) (OQ712) (OQ713), -Si (Q714) (Q715) (Q716) ";
At that time, Q665, Q666, Q667, Q668, Q669, Q670, Q671, Q672, Q673, Q674, Q675, Q676, Q677, Q678, Q679, Q680, Q681, Q682, Q683, Q684, Q685, Q686, Q687 Q689, Q690, Q691, Q692, Q693, Q694, Q695, Q696, Q697, Q698, Q699, Q700, Q701, Q702, Q703, Q704, Q705, Q706, Q707, Q708, Q709, Q710, Q711, Q712, Q711 , Q714, Q715, Q716 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q671, Q672 and / or Q680, Q681 and / or Q693, Q694 and / or Q700, Q701 and / or Q709, Q710 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ717, -NQ718Q719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q720, -C (O) O-Q721, -C (O) NH-Q722, -C (O) NQ723Q724, -O-Q725, -O (-Q726-O) _e -H (e = 1, 2, 3, 4, 5), -O (-Q727-O) _e -Q728 (e = 1, 2, 3, 4, 5), -OC (O) -Q729, -OC (O) -O-Q730, -OC (O) -NHQ731, -O-C (O)- NQ732Q733, -OP (O) (OQ734) (OQ735), -OSi (Q736) (Q737) (Q738), -OS (O ₂ ) -Q739, -NHC (O) -Q740, -NQ741C (O) -Q742, -NH-C (O) -O-Q743, -NH-C (O) -NH-Q744, -NH-C (O ) -NQ745Q746, -NQ747-C (O) -O-Q748, -NQ749-C (O) -NH-Q750, -NQ751-C (O) -NQ752Q753, -NHS (O ₂ ) -Q754, -NQ755S (O ₂ ) -Q756, -S-Q757, -S (O) -Q758, -S (O ₂ ) -Q759, -S (O ₂ ) NH-Q760, -S (O ₂ ) NQ761Q762, -S (O ₂ ) O-Q763, -P (O) (OQ764) (OQ765), -Si (Q766) (Q767) (Q768) ";
At that time, Q717, Q718, Q719, Q720, Q721, Q722, Q723, Q724, Q725, Q726, Q727, Q728, Q729, Q730, Q731, Q732, Q733, Q734, Q735, Q736, Q737, Q738, Q739, Q7 Q741, Q742, Q743, Q744, Q745, Q746, Q747, Q748, Q749, Q750, Q751, Q752, Q753, Q754, Q755, Q756, Q757, Q758, Q759, Q760, Q761, Q762, Q763, 764 , Q766, Q767, Q768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q723, Q724 and / or Q732, Q733 and / or Q745, Q746 and / or Q752, Q753 and / or Q761, Q762 can each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ769, -NQ770Q771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q772, -C (O) O-Q773, -C (O) NH-Q774, -C (O) NQ775Q776, -O-Q777, -O (-Q778-O) _f -H (f = 1, 2, 3, 4, 5), -O (-Q779-O) _f -Q780 (f = 1, 2, 3, 4, 5), -OC (O) -Q781, -OC (O) -O-Q782, -OC (O) -NHQ783, -O-C (O)- NQ784Q785, -OP (O) (OQ786) (OQ787), -OSi (Q788) (Q789) (Q790), -OS (O ₂ ) -Q791, -NHC (O) -Q792, -NQ793C (O) -Q794, -NH-C (O) -O-Q795, -NH-C (O) -NH-Q796, -NH-C (O ) -NQ797Q798, -NQ799-C (O) -O-Q800, -NQ801-C (O) -NH-Q802, -NQ803-C (O) -NQ804Q805, -NHS (O ₂ ) -Q806, -NQ807S (O ₂ ) -Q808, -S-Q809, -S (O) -Q810, -S (O ₂ ) -Q811, -S (O ₂ ) NH-Q812, -S (O ₂ ) NQ813Q814, -S (O ₂ ) O-Q815, -P (O) (OQ816) (OQ817), -Si (Q818) (Q819) (Q820) ";
At that time, Q769, Q770, Q771, Q772, Q773, Q774, Q775, Q776, Q777, Q778, Q779, Q780, Q781, Q782, Q783, Q784, Q785, Q786, Q787, Q788, Q789, Q790, Q791, Q79 Q793, Q794, Q795, Q796, Q797, Q798, Q799, Q800, Q801, Q802, Q803, Q804, Q805, Q806, Q807, Q808, Q809, Q810, Q811, Q812, Q813, Q814, Q815, Q816 , Q818, Q819, Q820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q775, Q776 and / or Q784, Q785 and / or Q797, Q798 and / or Q804, Q805 and / or Q813, Q814 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ821, -NQ822Q823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q824, -C (O) O-Q825, -C (O) NH-Q826, -C (O) NQ827Q828, -O-Q829, -O (-Q830-O) _g -H (g = 1, 2, 3, 4, 5), -O (-Q831-O) _g -Q832 (g = 1, 2, 3, 4, 5), -OC (O) -Q833, -OC (O) -O-Q834, -OC (O) -NHQ835, -O-C (O)- NQ836Q837, -OP (O) (OQ838) (OQ839), -OSi (Q840) (Q841) (Q842), -OS (O ₂ ) -Q843, -NHC (O) -Q844, -NQ845C (O) -Q846, -NH-C (O) -O-Q847, -NH-C (O) -NH-Q848, -NH-C (O ) -NQ849Q850, -NQ851-C (O) -O-Q852, -NQ853-C (O) -NH-Q854, -NQ855-C (O) -NQ856Q857, -NHS (O ₂ ) -Q858, -NQ859S (O ₂ ) -Q860, -S-Q861, -S (O) -Q862, -S (O ₂ ) -Q863, -S (O ₂ ) NH-Q864, -S (O ₂ ) NQ865Q866, -S (O ₂ ) O-Q867, -P (O) (OQ868) (OQ869), -Si (Q870) (Q871) (Q872) ";
At that time, Q821, Q822, Q823, Q824, Q825, Q826, Q827, Q828, Q829, Q830, Q831, Q832, Q833, Q834, Q835, Q836, Q837, Q838, Q839, Q840, Q841, Q842, Q843 Q845, Q846, Q847, Q848, Q849, Q850, Q851, Q852, Q853, Q854, Q855, Q856, Q857, Q858, Q859, Q860, Q861, Q862, Q863, Q864, Q865, Q866, Q867, 86 , Q870, Q871, Q872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q827, Q828 and / or Q836, Q837 and / or Q849, Q850 and / or Q856, Q857 and / or Q865, Q866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ873, -NQ874Q875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q876, -C (O) O-Q877, -C (O) NH-Q878, -C (O) NQ879Q880, -O-Q881, -O (-Q882-O) _h -H (h = 1, 2, 3, 4, 5), -O (-Q883-O) _h -Q884 (h = 1, 2, 3, 4, 5), -OC (O) -Q885, -OC (O) -O-Q886, -OC (O) -NHQ887, -O-C (O)- NQ888Q889, -OP (O) (OQ890) (OQ891), -OSi (Q892) (Q893) (Q894), -OS (O ₂ ) -Q895, -NHC (O) -Q896, -NQ897C (O) -Q898, -NH-C (O) -O-Q899, -NH-C (O) -NH-Q900, -NH-C (O ) -NQ901Q902, -NQ903-C (O) -O-Q904, -NQ905-C (O) -NH-Q906, -NQ907-C (O) -NQ908Q909, -NHS (O ₂ ) -Q910, -NQ911S (O ₂ ) -Q912, -S-Q913, -S (O) -Q914, -S (O ₂ ) -Q915, -S (O ₂ ) NH-Q916, -S (O ₂ ) NQ917Q918, -S (O ₂ ) O-Q919, -P (O) (OQ920) (OQ921), -Si (Q922) (Q923) (Q924) ";
At that time, Q873, Q874, Q875, Q876, Q877, Q878, Q879, Q880, Q881, Q882, Q883, Q884, Q885, Q886, Q887, Q888, Q889, Q890, Q891, Q892, Q893, Q894, Q895 Q897, Q898, Q899, Q900, Q901, Q902, Q903, Q904, Q905, Q906, Q907, Q908, Q909, Q910, Q911, Q912, Q913, Q914, Q915, Q916, Q917, Q918, Q919, Q920 , Q922, Q923, Q924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q879, Q880 and / or Q888, Q889 and / or Q901, Q902 and / or Q908, Q909 and / or Q917, Q918 can each be taken together to form a "heterocyclyl";
(J) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ925, -NQ926Q927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q928, -C (O) O-Q929, -C (O) NH-Q930, -C (O) NQ931Q932, -O-Q933, -O (-Q934-O) _i -H (i = 1, 2, 3, 4, 5), -O (-Q935-O) _i -Q936 (i = 1, 2, 3, 4, 5), -OC (O) -Q937, -OC (O) -O-Q938, -OC (O) -NHQ939, -O-C (O)- NQ940Q941, -OP (O) (OQ942) (OQ943), -OSi (Q944) (Q945) (Q946), -OS (O ₂ ) -Q947, -NHC (O) -Q948, -NQ949C (O) -Q950, -NH-C (O) -O-Q951, -NH-C (O) -NH-Q952, -NH-C (O ) -NQ953Q954, -NQ955-C (O) -O-Q956, -NQ957-C (O) -NH-Q958, -NQ959-C (O) -NQ960Q961, -NHS (O ₂ ) -Q962, -NQ963S (O ₂ ) -Q964, -S-Q965, -S (O) -Q966, -S (O ₂ ) -Q967, -S (O ₂ ) NH-Q968, -S (O ₂ ) NQ969Q970, -S (O ₂ ) O-Q971, -P (O) (OQ972) (OQ973), -Si (Q974) (Q975) (Q976) ";
At that time, Q925, Q926, Q927, Q928, Q929, Q930, Q931, Q932, Q933, Q934, Q935, Q936, Q937, Q938, Q939, Q940, Q941, Q942, Q943, Q944, Q945, Q946, Q947, Q948 Q949, Q950, Q951, Q952, Q953, Q954, Q955, Q956, Q957, Q958, Q959, Q960, Q961, Q962, Q963, Q964, Q965, Q966, Q967, Q968, Q969, Q970, Q971, Q972 , Q974, Q975, Q976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q931, Q932 and / or Q940, Q941 and / or Q953, Q954 and / or Q960, Q961 and / or Q969, Q970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ977, -NQ978Q979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q980, -C (O) O-Q981, -C (O) NH-Q982, -C (O) NQ983Q984, -O-Q985, -O (-Q986-O) _j -H (j = 1, 2, 3, 4, 5), -O (-Q987-O) _j -Q988 (j = 1, 2, 3, 4, 5), -OC (O) -Q989, -OC (O) -O-Q990, -OC (O) -NHQ991, -O-C (O)- NQ992Q993, -OP (O) (OQ994) (OQ995), -OSi (Q996) (Q997) (Q998), -OS (O ₂ ) -Q999, -NHC (O) -Q1000, -NQ1001C (O) -Q1002, -NH-C (O) -O-Q1003, -NH-C (O) -NH-Q1004, -NH-C (O ) -NQ1005Q1006, -NQ1007-C (O) -O-Q1008, -NQ1009-C (O) -NH-Q1010, -NQ1011-C (O) -NQ1012Q1013, -NHS (O ₂ ) -Q1014, -NQ1015S (O ₂ ) -Q1016, -S-Q1017, -S (O) -Q1018, -S (O ₂ ) -Q1019, -S (O ₂ ) NH-Q1020, -S (O ₂ ) NQ1021Q1022, -S (O ₂ ) O-Q1023, -P (O) (OQ1024) (OQ1025), -Si (Q1026) (Q1027) (Q1028) ";
At that time, Q977, Q978, Q979, Q980, Q981, Q982, Q983, Q984, Q985, Q986, Q987, Q988, Q989, Q990, Q991, Q992, Q993, Q994, Q995, Q996, Q997, Q998, 1000 Q1001, Q1002, Q1003, Q1004, Q1005, Q1006, Q1007, Q1008, Q1009, Q1010, Q1011, Q1012, Q1013, Q1014, Q1015, Q1016, Q1017, Q1018, Q1019, Q1020, Q1021, Q1022, Q1023, Q1024 , Q1026, Q1027, Q1028 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q983, Q984 and / or Q992, Q993 and / or Q1005, Q1006 and / or Q1012, Q1013 and / or Q1021, Q1022 can each be taken together to form a "heterocyclyl";
(K) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1029, -NQ1030Q1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1032, -C (O) O-Q1033, -C (O) NH-Q1034, -C (O) NQ1035Q1036, -O-Q1037, -O (-Q1038-O) _k -H (k = 1, 2, 3, 4, 5), -O (-Q1039-O) _k -Q1040 (k = 1, 2, 3, 4, 5), -OC (O) -Q1041, -OC (O) -O-Q1042, -OC (O) -NHQ1043, -O-C (O)- NQ1044Q1045, -OP (O) (OQ1046) (OQ1047), -OSi (Q1048) (Q1049) (Q1050), -OS (O ₂ ) -Q1051, -NHC (O) -Q1052, -NQ1053C (O) -Q1054, -NH-C (O) -O-Q1055, -NH-C (O) -NH-Q1056, -NH-C (O ) -NQ1057Q1058, -NQ1059-C (O) -O-Q1060, -NQ1061-C (O) -NH-Q1062, -NQ1063-C (O) -NQ1064Q1065, -NHS (O ₂ ) -Q1066, -NQ1067S (O ₂ ) -Q1068, -S-Q1069, -S (O) -Q1070, -S (O ₂ ) -Q1071, -S (O ₂ ) NH-Q1072, -S (O ₂ ) NQ1073Q1074, -S (O ₂ ) O-Q1075, -P (O) (OQ1076) (OQ1077), -Si (Q1078) (Q1079) (Q1080) ";
At that time, Q1029, Q1030, Q1031, Q1032, Q1033, Q1034, Q1035, Q1036, Q1037, Q1038, Q1039, Q1040, Q1041, Q1042, Q1043, Q1044, Q1045, Q1046, Q1047, Q1048, Q1049, Q1050, Q1051, Q105 Q1053, Q1054, Q1055, Q1056, Q1057, Q1058, Q1059, Q1060, Q1061, Q1062, Q1063, Q1064, Q1065, Q1066, Q1067, Q1068, Q1069, Q1070, Q1071, Q1072, Q1073, Q1074, Q1075, Q1076 , Q1078, Q1079, Q1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1035, Q1036 and / or Q1044, Q1045 and / or Q1057, Q1058 and / or Q1064, Q1065 and / or Q1073, Q1074 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1081, -NQ1082Q1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1084, -C (O) O-Q1085, -C (O) NH-Q1086, -C (O) NQ1087Q1088, -O-Q1089, -O (-Q1090-O) _l -H (l = 1, 2, 3, 4, 5), -O (-Q1091-O) _l -Q1092 (l = 1, 2, 3, 4, 5), -OC (O) -Q1093, -OC (O) -O-Q1094, -OC (O) -NHQ1095, -O-C (O)- NQ1096Q1097, -OP (O) (OQ1098) (OQ1099), -OSi (Q1100) (Q1101) (Q1102), -OS (O ₂ ) -Q1103, -NHC (O) -Q1104, -NQ1105C (O) -Q1106, -NH-C (O) -O-Q1107, -NH-C (O) -NH-Q1108, -NH-C (O ) -NQ1109Q1110, -NQ1111-C (O) -O-Q1112, -NQ1113-C (O) -NH-Q1114, -NQ1115-C (O) -NQ1116Q1117, -NHS (O ₂ ) -Q1118, -NQ1119S (O ₂ ) -Q1120, -S-Q1121, -S (O) -Q1122, -S (O ₂ ) -Q1123, -S (O ₂ ) NH-Q1124, -S (O ₂ ) NQ1125Q1126, -S (O ₂ ) O-Q1127, -P (O) (OQ1128) (OQ1129), -Si (Q1130) (Q1131) (Q1132) ";
At that time, Q1081, Q1082, Q1083, Q1084, Q1085, Q1086, Q1087, Q1088, Q1089, Q1090, Q1091, Q1092, Q1093, Q1094, Q1095, Q1096, Q1097, Q1098, Q1099, Q1100, Q1101, Q1102, Q1103, Q1104 Q1105, Q1106, Q1107, Q1108, Q1109, Q1110, Q1111, Q1112, Q1113, Q1114, Q1115, Q1116, Q1117, Q1118, Q1119, Q1120, Q1121, Q1122, Q1123, Q1124, Q1125, Q1126, Q1127, Q1128 , Q1130, Q1131, and Q1132 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1087, Q1088 and / or Q1096, Q1097 and / or Q1109, Q1110 and / or Q1116, Q1117 and / or Q1125, Q1126 can each be taken together to form a "heterocyclyl";
(L) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -Q1133, -C (O) O-Q1134, -C (O)- NQ1135Q1136, -S (O ₂ ) -Q1137, -S (O ₂ ) O-Q1138 ";
In this case, Q1133, Q1134, Q1135, Q1136, Q1137, and Q1138 are independent of each other, “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, Q1135, Q1136 taken together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1139, -NQ1140Q1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1142, -C (O) O-Q1143, -C (O) NH-Q1144, -C (O) NQ1145Q1146, -O-Q1147, -O (-Q1148-O) _m -H (m = 1, 2, 3, 4, 5), -O (-Q1149-O) _m -Q1150 (m = 1, 2, 3, 4, 5), -OC (O) -Q1151, -OC (O) -O-Q1152, -OC (O) -NHQ1153, -O-C (O)- NQ1154Q1155, -OP (O) (OQ1156) (OQ1157), -OSi (Q1158) (Q1159) (Q1160), -OS (O ₂ ) -Q1161, -NHC (O) -Q1162, -NQ1163C (O) -Q1164, -NH-C (O) -O-Q1165, -NH-C (O) -NH-Q1166, -NH-C (O ) -NQ1167Q1168, -NQ1169-C (O) -O-Q1170, -NQ1171-C (O) -NH-Q1172, -NQ1173-C (O) -NQ1174Q1175, -NHS (O ₂ ) -Q1176, -NQ1177S (O ₂ ) -Q1178, -S-Q1179, -S (O) -Q1180, -S (O ₂ ) -Q1181, -S (O ₂ ) NH-Q1182, -S (O ₂ ) NQ1183Q1184, -S (O ₂ ) O-Q1185, -P (O) (OQ1186) (OQ1187), -Si (Q1188) (Q1189) (Q1190) ";
At that time, Q1139, Q1140, Q1141, Q1142, Q1143, Q1144, Q1145, Q1146, Q1147, Q1148, Q1149, Q1150, Q1151, Q1152, Q1153, Q1154, Q1155, Q1156, Q1157, Q1158, Q1159, Q1160, Q1161, Q2 Q1163, Q1164, Q1165, Q1166, Q1167, Q1168, Q1169, Q1170, Q1171, Q1172, Q1173, Q1174, Q1175, Q1176, Q1177, Q1178, Q1179, Q1180, Q1181, Q1182, Q1183, Q1184, Q1185, Q1186, Q1185, Q1186 , Q1188, Q1189, Q1190 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1145, Q1146 and / or Q1154, Q1155 and / or Q1167, Q1168 and / or Q1174, Q1175 and / or Q1183, Q1184 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHQ1191, -NQ1192Q1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -Q1194, -C (O) O-Q1195, -C (O) NH-Q1196, -C (O) NQ1197Q1198, -O-Q1199, -O (-Q1200-O) _n -H (n = 1, 2, 3, 4, 5), -O (-Q1201-O) _n -Q1202 (n = 1, 2, 3, 4, 5), -OC (O) -Q1203, -OC (O) -O-Q1204, -OC (O) -NHQ1205, -O-C (O)- NQ1206Q1207, -OP (O) (OQ1208) (OQ1209), -OSi (Q1210) (Q1211) (Q1212), -OS (O ₂ ) -Q1213, -NHC (O) -Q1214, -NQ1215C (O) -Q1216, -NH-C (O) -O-Q1217, -NH-C (O) -NH-Q1218, -NH-C (O ) -NQ1219Q1220, -NQ1221-C (O) -O-Q1222, -NQ1223-C (O) -NH-Q1224, -NQ1225-C (O) -NQ1226Q1227, -NHS (O ₂ ) -Q1228, -NQ1229S (O ₂ ) -Q1230, -S-Q1231, -S (O) -Q1232, -S (O ₂ ) -Q1233, -S (O ₂ ) NH-Q1234, -S (O ₂ ) NQ1235Q1236, -S (O ₂ ) O-Q1237, -P (O) (OQ1238) (OQ1239), -Si (Q1240) (Q1241) (Q1242) ";
At that time, Q1191, Q1192, Q1193, Q1194, Q1195, Q1196, Q1197, Q1198, Q1199, Q1200, Q1201, Q1202, Q1203, Q1204, Q1205, Q1206, Q1207, Q1208, Q1209, Q1210, Q1211, Q1212, Q1213, Q12 Q1215, Q1216, Q1217, Q1218, Q1219, Q1220, Q1221, Q1222, Q1223, Q1224, Q1225, Q1226, Q1227, Q1228, Q1229, Q1230, Q1231, Q1232, Q1233, Q1234, Q1235, Q1236, Q1237, 3938 , Q1240, Q1241, Q1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally Q1197, Q1198 and / or Q1206, Q1207 and / or Q1219, Q1220 and / or Q1226, Q1227 and / or Q1235, Q1236 can each be taken together to form a “heterocyclyl”;
as well as
The radicals Z1, Z2 are independently selected from the group consisting of “hydrogen, NZ14Z15”;
However, when Z1 = 1, Z2 = NZ14Z15 and when Z1 = NZ14Z15, Z2 = H;
Z14 and Z15 are then selected from the group consisting of:
(A) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (Y1) NZ16Z17, -C (= NZ18) -Z19, -C (Y2) NZ20- Y3-Z21 ";
However, Z14 and Z15 are simultaneously hydrogen or “alkyl, C ₉ ~ C ₃₀ -Not "alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl";
However, in addition, one of the groups Z14, Z15 is hydrogen or "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ", wherein the other group Z14, Z15 is" -C (Y1) NZ16Z17 "," -C (= NZ18) -Z19 "or" -C (Y2) NZ20-Y3-Z21 ";
Y1, Y2, Y3 are then selected from the group consisting of “O, S, ═NH, ═NZ22” independently of each other;
In so doing, Z16, Z17, Z18, Z19, Z20, Z21, Z22 are independently selected from the group consisting of:
(1) hydrogen;
(2) "Alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl ";
In this case, the substituents of the substituent group (a) and / or the substituent group (2) are at least one substituent selected from the group consisting of the following, independently of each other, and optionally the same or different: May be substituted by a group:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU1, -NU2U3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U4, -C (O) O-U5, -C (O) NH-U6, -C (O) NU7U8, -O-U9, -O (-U10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-U11-O) _r -U12 (r = 1, 2, 3, 4, 5), -OC (O) -U13, -OC (O) -O-U14, -OC (O) -NHU15, -O-C (O)- NU16U17, -OP (O) (OU18) (OU19), -OSi (U20) (U21) (U22), -OS (O ₂ ) -U23, -NHC (O) -U24, -NU25C (O) -U26, -NH-C (O) -O-U27, -NH-C (O) -NH-U28, -NH-C (O ) -NU29U30, -NU31-C (O) -O-U32, -NU33-C (O) -NH-U34, -NU35-C (O) -NU36U37, -NHS (O ₂ ) -U38, -NU39S (O ₂ ) -U40, -S-U41, -S (O) -U42, -S (O ₂ ) -U43, -S (O ₂ ) NH-U44, -S (O ₂ ) NU45U46, -S (O ₂ ) O-U47, -P (O) (OU48) (OU49), -Si (U50) (U51) (U52) ";
At that time, U1, U2, U3, U4, U5, U6, U7, U8, U9, U10, U11, U12, U13, U14, U15, U16, U17, U18, U19, U20, U21, U22, U23, U24 U25, U26, U27, U28, U29, U30, U31, U32, U33, U34, U35, U36, U37, U38, U39, U40, U41, U42, U43, U44, U45, U46, U47, U48, U49 , U50, U51, U52 are independent of each other, "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U7, U8 and / or U16, U17 and / or U29, U30 and / or U36, U37 and / or U45, U46 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU53, -NU54U55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U56, -C (O) O-U57, -C (O) NH-U58, -C (O) NU59U60, -O-U61, -O (-U62-O) _r -H (r = 1, 2, 3, 4, 5), -O (-U63-O) _r -U64 (r = 1, 2, 3, 4, 5), -OC (O) -U65, -OC (O) -O-U66, -OC (O) -NHU67, -O-C (O)- NU68U69, -OP (O) (OU70) (OU71), -OSi (U72) (U73) (U74), -OS (O ₂ ) -U75, -NHC (O) -U76, -NU77C (O) -U78, -NH-C (O) -O-U79, -NH-C (O) -NH-U80, -NH-C (O ) -NU81U82, -NU83-C (O) -O-U84, -NU85-C (O) -NH-U86, -NU87-C (O) -NU88U89, -NHS (O ₂ ) -U90, -NU91S (O ₂ ) -U92, -S-U93, -S (O) -U94, -S (O ₂ ) -U95, -S (O ₂ ) NH-U96, -S (O ₂ ) NU97U98, -S (O ₂ ) O-U99, -P (O) (OU100) (OU101), -Si (U102) (U103) (U104) ";
At that time, U53, U54, U55, U56, U57, U58, U59, U60, U61, U62, U63, U64, U65, U66, U67, U68, U69, U70, U71, U72, U73, U74, U75, U76 U77, U78, U79, U80, U81, U82, U83, U84, U85, U86, U87, U88, U89, U90, U91, U92, U93, U94, U95, U96, U97, U98, U99, U100, U101 , U102, U103, U104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U59, U60 and / or U68, U69 and / or U81, U82 and / or U88, U89 and / or U97, U98 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU105, -NU106U107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U108, -C (O) O-U109, -C (O) NH-U110, -C (O) NU111U112, -O-U113, -O (-U114-O) _s -H (s = 1, 2, 3, 4, 5), -O (-U115-O) _s -U116 (s = 1, 2, 3, 4, 5), -OC (O) -U117, -OC (O) -O-U118, -OC (O) -NHU119, -O-C (O)- NU120U121, -OP (O) (OU122) (OU123), -OSi (U124) (U125) (U126), -OS (O ₂ ) -U127, -NHC (O) -U128, -NU129C (O) -U130, -NH-C (O) -O-U131, -NH-C (O) -NH-U132, -NH-C (O ) -NU133U134, -NU135-C (O) -O-U136, -NU137-C (O) -NH-U138, -NU139-C (O) -NU140U141, -NHS (O ₂ ) -U142, -NU143S (O ₂ ) -U144, -S-U145, -S (O) -U146, -S (O ₂ ) -U147, -S (O ₂ ) NH-U148, -S (O ₂ ) NU149U150, -S (O ₂ ) O-U151, -P (O) (OU152) (OU153), -Si (U154) (U155) (U156) ";
At that time, U105, U106, U107, U108, U109, U110, U111, U112, U113, U114, U115, U116, U117, U118, U119, U120, U121, U122, U123, U124, U125, U126, U127, U128 , U129, U130, U131, U132, U133, U134, U135, U136, U137, U138, U139, U140, U141, U142, U143, U144, U145, U146, U147, U148, U149, U150, U151, U152, U153 , U154, U155, U156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U111, U112 and / or U120, U121 and / or U133, U134 and / or U140, U141 and / or U149, U150 may each be taken together to form a "heterocyclyl";
(3) -C (O) -Z23,
Z23 is then independently selected from the group consisting of:
(A) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (a) may be substituted by at least one substituent selected from the group consisting of the following, independently or optionally, the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU157, -NU158U159, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U160, -C (O) O-U161, -C (O) NH-U162, -C (O) NU163U164, -O-U165, -O (-U166-O) _t -H (t = 1, 2, 3, 4, 5), -O (-U167-O) _t -U168 (t = 1, 2, 3, 4, 5), -OC (O) -U169, -OC (O) -O-U170, -OC (O) -NHU171, -O-C (O)- NU172U173, -OP (O) (OU174) (OU175), -OSi (U176) (U177) (U178), -OS (O ₂ ) -U179, -NHC (O) -U180, -NU181C (O) -U182, -NH-C (O) -O-U183, -NH-C (O) -NH-U184, -NH-C (O ) -NU185U186, -NU187-C (O) -O-U188, -NU189-C (O) -NH-U190, -NU191-C (O) -NU192U193, -NHS (O ₂ ) -U194, -NU195S (O ₂ ) -U196, -S-U197, -S (O) -U198, -S (O ₂ ) -U199, -S (O ₂ ) NH-U200, -S (O ₂ ) NU201U202, -S (O ₂ ) O-U203, -P (O) (OU204) (OU205), -Si (U206) (U207) (U208) ";
At that time, U157, U158, U159, U160, U161, U162, U163, U164, U165, U166, U167, U168, U169, U170, U171, U172, U173, U174, U175, U176, U177, U178, U179, U180 U181, U182, U183, U184, U185, U186, U187, U188, U189, U190, U191, U192, U193, U194, U195, U196, U197, U198, U199, U200, U201, U202, U203, U204, U205 , U206, U207, U208 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U163, U164 and / or U172, U173 and / or U185, U186 and / or U192, U193 and / or U201, U202 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU209, -NU210U211, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U212, -C (O) O-U213, -C (O) NH-U214, -C (O) NU215U216, -O-U217, -O (-U218-O) _u -H (u = 1, 2, 3, 4, 5), -O (-U219-O) _u -U220 (u = 1, 2, 3, 4, 5), -OC (O) -U221, -OC (O) -O-U222, -OC (O) -NHU223, -O-C (O)- NU224U225, -OP (O) (OU226) (OU227), -OSi (U228) (U229) (U230), -OS (O ₂ ) -U231, -NHC (O) -U232, -NU233C (O) -U234, -NH-C (O) -O-U235, -NH-C (O) -NH-U236, -NH-C (O ) -NU237U238, -NU239-C (O) -O-U240, -NU241-C (O) -NH-U242, -NU243-C (O) -NU244U245, -NHS (O ₂ ) -U246, -NU247S (O ₂ ) -U248, -S-U249, -S (O) -U250, -S (O ₂ ) -U251, -S (O ₂ ) NH-U252, -S (O ₂ ) NU253U254, -S (O ₂ ) O-U255, -P (O) (OU256) (OU257), -Si (U258) (U259) (U260) ";
At that time, U209, U210, U211, U212, U213, U214, U215, U216, U217, U218, U219, U220, U221, U222, U223, U224, U225, U226, U227, U228, U229, U230, U231, U232 , U233, U234, U235, U236, U237, U238, U239, U240, U241, U242, U243, U244, U245, U246, U247, U248, U249, U250, U251, U252, U253, U254, U255, U256, U255 , U258, U259, U260 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U215, U216 and / or U224, U225 and / or U237, U238 and / or U244, U245 and / or U253, U254 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU261, -NU262U263, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U264, -C (O) O-U265, -C (O) NH-U266, -C (O) NU267U268, -O-U269, -O (-U270-O) _v -H (v = 1, 2, 3, 4, 5), -O (-U271-O) _v -U272 (v = 1, 2, 3, 4, 5), -OC (O) -U273, -OC (O) -O-U274, -OC (O) -NHU275, -O-C (O)- NU276U277, -OP (O) (OU278) (OU279), -OSi (U280) (U281) (U282), -OS (O ₂ ) -U283, -NHC (O) -U284, -NU285C (O) -U286, -NH-C (O) -O-U287, -NH-C (O) -NH-U288, -NH-C (O ) -NU289U290, -NU291-C (O) -O-U292, -NU293-C (O) -NH-U294, -NU295-C (O) -NU296U297, -NHS (O ₂ ) -U298, -NU299S (O ₂ ) -U300, -S-U301, -S (O) -U302, -S (O ₂ ) -U303, -S (O ₂ ) NH-U304, -S (O ₂ ) NU305U306, -S (O ₂ ) O-U307, -P (O) (OU308) (OU309), -Si (U310) (U311) (U312) ";
At that time, U261, U262, U263, U264, U265, U266, U267, U268, U269, U270, U271, U272, U273, U274, U275, U276, U277, U278, U279, U280, U281, U282, U283, U284 , U285, U286, U287, U288, U289, U290, U291, U292, U293, U294, U295, U296, U297, U298, U299, U300, U301, U302, U303, U304, U305, U306, U307, U308, U309 , U310, U311 and U312 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U267, U268 and / or U276, U277 and / or U289, U290 and / or U296, U297 and / or U305, U306 may each be taken together to form a “heterocyclyl”;
(4) Z16, Z17 can be optionally joined together to form "heterocyclyl";
(5) "-C (O) -C (O) -U313, -S (O ₂ ) -NU314U315 ";
U313, U314, and U315 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU316, -NU317U318, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U319, -C (O) O-U320, -C (O) NH-U321, -C (O) NU322U323, -O-U324, -O (-U325-O) _w -H (w = 1, 2, 3, 4, 5), -O (-U326-O) _w -U327 (w = 1, 2, 3, 4, 5), -OC (O) -U328, -OC (O) -O-U329, -OC (O) -NHU330, -O-C (O)- NU331U332, -OP (O) (OU333) (OU334), -OSi (U335) (U336) (U337), -OS (O ₂ ) -U338, -NHC (O) -U339, -NU340C (O) -U341, -NH-C (O) -O-U342, -NH-C (O) -NH-U343, -NH-C (O ) -NU344U345, -NU346-C (O) -O-U347, -NU348-C (O) -NH-U349, -NU350-C (O) -NU351U352, -NHS (O ₂ ) -U353, -NU354S (O ₂ ) -U355, -S-U356, -S (O) -U357, -S (O ₂ ) -U358, -S (O ₂ ) NH-U359, -S (O ₂ ) NU360U361, -S (O ₂ ) O-U362, -P (O) (OU363) (OU364), -Si (U365) (U366) (U367) ";
At that time, U316, U317, U318, U319, U320, U321, U322, U323, U324, U325, U326, U327, U328, U329, U330, U331, U332, U333, U334, U335, U336, U337, U338, U339 U340, U341, U342, U343, U344, U345, U346, U347, U348, U349, U350, U351, U352, U353, U354, U355, U356, U357, U358, U359, U360, U361, U362, U363 , U365, U366, U367 are independently of each other "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U322, U323 and / or U331, U332 and / or U344, U345 and / or U351, U352 and / or U360, U361 may each be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU368, -NU369U370, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U371, -C (O) O-U372, -C (O) NH-U373, -C (O) NU374U375, -O-U376, -O (-U377-O) _x -H (x = 1, 2, 3, 4, 5), -O (-U378-O) _x -U379 (x = 1, 2, 3, 4, 5), -OC (O) -U380, -OC (O) -O-U381, -OC (O) -NHU382, -O-C (O)- NU383U384, -OP (O) (OU385) (OU386), -OSi (U387) (U388) (U389), -OS (O ₂ ) -U390, -NHC (O) -U391, -NU392C (O) -U393, -NH-C (O) -O-U394, -NH-C (O) -NH-U395, -NH-C (O ) -NU396U397, -NU398-C (O) -O-U399, -NU400-C (O) -NH-U401, -NU402-C (O) -NU403U404, -NHS (O ₂ ) -U405, -NU406S (O ₂ ) -U407, -S-U408, -S (O) -U409, -S (O ₂ ) -U410, -S (O ₂ ) NH-U411, -S (O ₂ ) NU412U413, -S (O ₂ ) O-U414, -P (O) (OU415) (OU416), -Si (U417) (U418) (U419) ";
At that time, U368, U369, U370, U371, U372, U373, U374, U375, U376, U377, U378, U379, U380, U381, U382, U383, U384, U385, U386, U387, U388, U389, U390, U39 , U392, U393, U394, U395, U396, U397, U398, U399, U400, U401, U402, U403, U404, U405, U406, U407, U408, U409, U410, U411, U412, U413, U414, U415, U416 , U417, U418, U419 are independently of each other "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U374, U375 and / or U383, U384 and / or U396, U397 and / or U403, U404 and / or U412, U413 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU420, -NU421U422, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U423, -C (O) O-U424, -C (O) NH-U425, -C (O) NU426U427, -O-U428, -O (-U429-O) _y -H (y = 1, 2, 3, 4, 5), -O (-U430-O) _y -U431 (y = 1, 2, 3, 4, 5), -OC (O) -U432, -OC (O) -O-U433, -OC (O) -NHU434, -O-C (O)- NU435U436, -OP (O) (OU437) (OU438), -OSi (U439) (U440) (U441), -OS (O ₂ ) -U442, -NHC (O) -U443, -NU444C (O) -U445, -NH-C (O) -O-U446, -NH-C (O) -NH-U447, -NH-C (O ) -NU448U449, -NU450-C (O) -O-U451, -NU452-C (O) -NH-U453, -NU454-C (O) -NU455U456, -NHS (O ₂ ) -U457, -NU458S (O ₂ ) -U459, -S-U460, -S (O) -U461, -S (O ₂ ) -U462, -S (O ₂ ) NH-U463, -S (O ₂ ) NU464U465, -S (O ₂ ) O-U466, -P (O) (OU467) (OU468), -Si (U469) (U470) (U471) ";
At that time, U420, U421, U422, U423, U424, U425, U426, U427, U428, U429, U430, U431, U432, U433, U434, U435, U436, U437, U438, U439, U440, U441, U442, U443 U444, U445, U446, U447, U448, U449, U450, U451, U452, U453, U454, U455, U456, U457, U458, U459, U460, U461, U462, U463, U464, U465, U466, U467 , U469, U470, U471 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U426, U427 and / or U435, U436 and / or U448, U449 and / or U455, U456 and / or U464, U465 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHU472, -NU473U474, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -U475, -C (O) O-U476, -C (O) NH-U477, -C (O) NU478U479, -O-U480, -O (-U481-O) _z -H (z = 1, 2, 3, 4, 5), -O (-U482-O) _z -U483 (z = 1, 2, 3, 4, 5), -OC (O) -U484, -OC (O) -O-U485, -OC (O) -NHU486, -O-C (O)- NU487U488, -OP (O) (OU489) (OU490), -OSi (U491) (U492) (U493), -OS (O ₂ ) -U494, -NHC (O) -U495, -NU496C (O) -U497, -NH-C (O) -O-U498, -NH-C (O) -NH-U499, -NH-C (O ) -NU500U501, -NU502-C (O) -O-U503, -NU504-C (O) -NH-U505, -NU506-C (O) -NU507U508, -NHS (O ₂ ) -U509, -NU510S (O ₂ ) -U511, -S-U512, -S (O) -U513, -S (O ₂ ) -U514, -S (O ₂ ) NH-U515, -S (O ₂ ) NU516U517, -S (O ₂ ) O-U518, -P (O) (OU519) (OU520), -Si (U521) (U522) (U523) ";
In that case, U472, U473, U474, U475, U476, U477, U478, U479, U480, U481, U482, U483, U484, U485, U486, U487, U488, U489, U490, U491, U492, U493, U494, U495 U496, U497, U498, U499, U500, U501, U502, U503, U504, U505, U506, U507, U508, U509, U510, U511, U512, U513, U514, U515, U516, U517, U518, U519, U520 , U521, U522, U523 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally U478, U479 and / or U487, U488 and / or U500, U501 and / or U507, U508 and / or U516, U517 may each be taken together to form a "heterocyclyl";
In so doing, optionally U314, U315 may be taken together to form a "heterocyclyl";
as well as
The group Z5 is independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHA1, -NA2A3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -A4, -C (O) O-A5, -C (O) NH-A6, -C (O) NA7A8, -O-A9, -O (-A10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-A11-O) _r -A12 (r = 1, 2, 3, 4, 5), -OC (O) -A13, -OC (O) -O-A14, -OC (O) -NHA15, -O-C (O)- NA16A17, -OP (O) (OA18) (OA19), -OSi (A20) (A21) (A22), -OS (O ₂ ) -A23, -NHC (O) -A24, -NA25C (O) -A26, -NH-C (O) -O-A27, -NH-C (O) -NH-A28, -NH-C (O ) -NA29A30, -NA31-C (O) -O-A32, -NA33-C (O) -NH-A34, -NA35-C (O) -NA36A37, -NHS (O ₂ ) -A38, -NA39S (O ₂ ) -A40, -S-A41, -S (O) -A42, -S (O ₂ ) -A43, -S (O ₂ ) NH-A44, -S (O ₂ ) NA45A46, -S (O ₂ ) O-A47, -P (O) (OA48) (OA49), -Si (A50) (A51) (A52) ";
At that time, A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24 A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A47, A48, A49 , A50, A51, A52 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally A7, A8 and / or A16, A17 and / or A29, A30 and / or A36, A37 and / or A45, A46 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHA53, -NA54A55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -A56, -C (O) O-A57, -C (O) NH-A58, -C (O) NA59A60, -O-A61, -O (-A62-O) _s -H (s = 1, 2, 3, 4, 5), -O (-A63-O) _s -A64 (s = 1, 2, 3, 4, 5), -OC (O) -A65, -OC (O) -O-A66, -OC (O) -NHA67, -O-C (O)- NA68A69, -OP (O) (OA70) (OA71), -OSi (A72) (A73) (A74), -OS (O ₂ ) -A75, -NHC (O) -A76, -NA77C (O) -A78, -NH-C (O) -O-A79, -NH-C (O) -NH-A80, -NH-C (O ) -NA81A82, -NA83-C (O) -O-A84, -NA85-C (O) -NH-A86, -NA87-C (O) -NA88A89, -NHS (O ₂ ) -A90, -NA91S (O ₂ ) -A92, -S-A93, -S (O) -A94, -S (O ₂ ) -A95, -S (O ₂ ) NH-A96, -S (O ₂ ) NA97A98, -S (O ₂ ) O-A99, -P (O) (OA100) (OA101), -Si (A102) (A103) (A104) ";
At that time, A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, A65, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76 A77, A78, A79, A80, A81, A82, A83, A84, A85, A86, A87, A88, A89, A90, A91, A92, A93, A94, A95, A96, A97, A98, A99, A100, A101 , A102, A103, A104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally A59, A60 and / or A68, A69 and / or A81, A82 and / or A88, A89 and / or A97, A98 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHA105, -NA106A107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -A108, -C (O) O-A109, -C (O) NH-A110, -C (O) NA111A112, -O-A113, -O (-A114-O) _t -H (t = 1, 2, 3, 4, 5), -O (-A115-O) _t -A116 (t = 1, 2, 3, 4, 5), -OC (O) -A117, -OC (O) -O-A118, -OC (O) -NHA119, -O-C (O)- NA120A121, -OP (O) (OA122) (OA123), -OSi (A124) (A125) (A126), -OS (O ₂ ) -A127, -NHC (O) -A128, -NA129C (O) -A130, -NH-C (O) -O-A131, -NH-C (O) -NH-A132, -NH-C (O ) -NA133A134, -NA135-C (O) -O-A136, -NA137-C (O) -NH-A138, -NA139-C (O) -NA140A141, -NHS (O ₂ ) -A142, -NA143S (O ₂ ) -A144, -S-A145, -S (O) -A146, -S (O ₂ ) -A147, -S (O ₂ ) NH-A148, -S (O ₂ ) NA149A150, -S (O ₂ ) O-A151, -P (O) (OA152) (OA153), -Si (A154) (A155) (A156) ";
At that time, A105, A106, A107, A108, A109, A110, A111, A112, A113, A114, A115, A116, A117, A118, A119, A120, A121, A122, A123, A124, A125, A126, A127, A128 A129, A130, A131, A132, A133, A134, A135, A136, A137, A138, A139, A140, A141, A142, A143, A144, A145, A146, A147, A148, A149, A150, A151, A152, A153 , A154, A155, A156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally A111, A112 and / or A120, A121 and / or A133, A134 and / or A140, A141 and / or A149, A150 may each be taken together to form a "heterocyclyl";
Or
(E)
One or both radicals Z1, Z2 of the radicals Z1, Z2, independently of one another, are selected from the group consisting of:
(A) -NZ24Z25;
However, one or both groups Z24, Z25 of the groups Z24, Z25, independently of one another, are selected from the group consisting of:
(1) "-C (O) -C (O) -T1, -S (O ₂ ) -NT2T3 ";
T1, T2, T3 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT4, -NT5T6, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T7, -C (O) O-T8, -C (O) NH-T9, -C (O) NT10T11, -O-T12, -O (-T13-O) _p -H (p = 1, 2, 3, 4, 5), -O (-T14-O) _p -T15 (p = 1, 2, 3, 4, 5), -OC (O) -T16, -OC (O) -O-T17, -OC (O) -NHT18, -O-C (O)- NT19T20, -OP (O) (OT21) (OT22), -OSi (T23) (T24) (T25), -OS (O ₂ ) -T26, -NHC (O) -T27, -NT28C (O) -T29, -NH-C (O) -O-T30, -NH-C (O) -NH-T31, -NH-C (O ) -NT32T33, -NT34-C (O) -O-T35, -NT36-C (O) -NH-T37, -NT38-C (O) -NT39T40, -NHS (O ₂ ) -T41, -NT42S (O ₂ ) -T43, -S-T44, -S (O) -T45, -S (O ₂ ) -T46, -S (O ₂ ) NH-T47, -S (O ₂ ) NT48T49, -S (O ₂ ) O-T50, -P (O) (OT51) (OT52), -Si (T53) (T54) (T55) ";
At that time, T4, T5, T6, T7, T8, T9, T10, T11, T12, T13, T14, T15, T16, T17, T18, T19, T20, T21, T22, T23, T24, T25, T26, T27 T28, T29, T30, T31, T32, T33, T34, T35, T36, T37, T38, T39, T40, T41, T42, T43, T44, T45, T46, T47, T48, T49, T50, T51, T52 , T53, T54, T55 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T10, T11 and / or T19, T20 and / or T32, T33 and / or T39, T40 and / or T48, T49 may each be taken together to form a “heterocyclyl”;
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT56, -NT57T58, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T59, -C (O) O-T60, -C (O) NH-T61, -C (O) NT62T63, -O-T64, -O (-T65-O) _r -H (r = 1, 2, 3, 4, 5), -O (-T66-O) _r -T67 (r = 1, 2, 3, 4, 5), -OC (O) -T68, -OC (O) -O-T69, -OC (O) -NHT70, -O-C (O)- NT71T72, -OP (O) (OT73) (OT74), -OSi (T75) (T76) (T77), -OS (O ₂ ) -T78, -NHC (O) -T79, -NT80C (O) -T81, -NH-C (O) -O-T82, -NH-C (O) -NH-T83, -NH-C (O ) -NT84T85, -NT86-C (O) -O-T87, -NT88-C (O) -NH-T89, -NT90-C (O) -NT91T92, -NHS (O ₂ ) -T93, -NT94S (O ₂ ) -T95, -S-T96, -S (O) -T97, -S (O ₂ ) -T98, -S (O ₂ ) NH-T99, -S (O ₂ ) NT100T101, -S (O ₂ ) O-T102, -P (O) (OT103) (OT104), -Si (T105) (T106) (T107) ";
At that time, T56, T57, T58, T59, T60, T61, T62, T63, T64, T65, T66, T67, T68, T69, T70, T71, T72, T73, T74, T75, T76, T77, T78, T79 T80, T81, T82, T83, T84, T85, T86, T87, T88, T89, T90, T91, T92, T93, T94, T95, T96, T97, T98, T99, T100, T101, T102, T103, T104 , T105, T106, T107 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T62, T63 and / or T71, T72 and / or T84, T85 and / or T91, T92 and / or T100, T101 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT108, -NT109T110, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T111, -C (O) O-T112, -C (O) NH-T113, -C (O) NT114T115, -O-T116, -O (-T117-O) _s -H (s = 1, 2, 3, 4, 5), -O (-T118-O) _s -T119 (s = 1, 2, 3, 4, 5), -OC (O) -T120, -OC (O) -O-T121, -OC (O) -NHT122, -O-C (O)- NT123T124, -OP (O) (OT125) (OT126), -OSi (T127) (T128) (T129), -OS (O ₂ ) -T130, -NHC (O) -T131, -NT132C (O) -T133, -NH-C (O) -O-T134, -NH-C (O) -NH-T135, -NH-C (O ) -NT136T137, -NT138-C (O) -O-T139, -NT140-C (O) -NH-T141, -NT142-C (O) -NT143T144, -NHS (O ₂ ) -T145, -NT146S (O ₂ ) -T147, -S-T148, -S (O) -T149, -S (O ₂ ) -T150, -S (O ₂ ) NH-T151, -S (O ₂ ) NT152T153, -S (O ₂ ) O-T154, -P (O) (OT155) (OT156), -Si (T157) (T158) (T159) ";
At that time, T108, T109, T110, T111, T112, T113, T114, T115, T116, T117, T118, T119, T120, T121, T122, T123, T124, T125, T126, T127, T128, T129, T130, T131 , T132, T133, T134, T135, T136, T137, T138, T139, T140, T141, T142, T143, T144, T145, T146, T147, T148, T149, T150, T151, T152, T153, T154, T155, T156 , T157, T158, T159 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T114, T115 and / or T123, T124 and / or T136, T137 and / or T143, T144 and / or T152, T153 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT160, -NT161T162, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T163, -C (O) O-T164, -C (O) NH-T165, -C (O) NT166T167, -O-T168, -O (-T169-O) _t -H (t = 1, 2, 3, 4, 5), -O (-T170-O) _t -T171 (t = 1, 2, 3, 4, 5), -OC (O) -T172, -OC (O) -O-T173, -OC (O) -NHT174, -O-C (O)- NT175T176, -OP (O) (OT177) (OT178), -OSi (T179) (T180) (T181), -OS (O ₂ ) -T182, -NHC (O) -T183, -NT184C (O) -T185, -NH-C (O) -O-T186, -NH-C (O) -NH-T187, -NH-C (O ) -NT188T189, -NT190-C (O) -O-T191, -NT192-C (O) -NH-T193, -NT194-C (O) -NT195T196, -NHS (O ₂ ) -T197, -NT198S (O ₂ ) -T199, -S-T200, -S (O) -T201, -S (O ₂ ) -T202, -S (O ₂ ) NH-T203, -S (O ₂ ) NT204T205, -S (O ₂ ) O-T206, -P (O) (OT207) (OT208), -Si (T209) (T210) (T211) ";
At that time, T160, T161, T162, T163, T164, T165, T166, T167, T168, T169, T170, T171, T172, T173, T174, T175, T176, T177, T178, T179, T180, T181, T182, T183 T184, T185, T186, T187, T188, T189, T190, T191, T192, T193, T194, T195, T196, T197, T198, T199, T200, T201, T202, T203, T204, T205, T206, T207, T208 , T209, T210, T211 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T166, T167 and / or T175, T176 and / or T188, T189 and / or T195, T196 and / or T204, T205 may each be taken together to form a “heterocyclyl”;
In so doing, optionally, T2, T3 may be taken together to form "heterocyclyl";
as well as
One of the groups Z24, Z25, independently of one another, is selected from the group consisting of: or neither of the groups Z24, Z25 is selected from the group consisting of:
(2) "Hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In that case, depending on the case, the substituents of the substituent group (2) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: Good:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT212, -NT213T214, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T215, -C (O) O-T216, -C (O) NH-T217, -C (O) NT218T219, -O-T220, -O (-T221-O) _u -H (u = 1, 2, 3, 4, 5), -O (-T222-O) _u -T223 (u = 1, 2, 3, 4, 5), -OC (O) -T224, -OC (O) -O-T225, -OC (O) -NHT226, -O-C (O)- NT227T228, -OP (O) (OT229) (OT230), -OSi (T231) (T232) (T233), -OS (O ₂ ) -T234, -NHC (O) -T235, -NT236C (O) -T237, -NH-C (O) -O-T238, -NH-C (O) -NH-T239, -NH-C (O ) -NT240T241, -NT242-C (O) -O-T243, -NT244-C (O) -NH-T245, -NT246-C (O) -NT247T248, -NHS (O ₂ ) -T249, -NT250S (O ₂ ) -T251, -S-T252, -S (O) -T253, -S (O ₂ ) -T254, -S (O ₂ ) NH-T255, -S (O ₂ ) NT256T257, -S (O ₂ ) O-T258, -P (O) (OT259) (OT260), -Si (T261) (T262) (T263) ";
At that time, T212, T213, T214, T215, T216, T217, T218, T219, T220, T221, T222, T223, T224, T225, T226, T227, T228, T229, T230, T231, T232, T233, T234, T235 , T236, T237, T238, T239, T240, T241, T242, T243, T244, T245, T246, T247, T248, T249, T250, T251, T252, T253, T254, T255, T256, T257, T258, T259, 260 , T261, T262, T263 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T218, T219 and / or T227, T228 and / or T240, T241 and / or T247, T248 and / or T256, T257 may be taken together to form a “heterocyclyl”;
In that case, the said substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other;
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT264, -NT265T266, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T267, -C (O) O-T268, -C (O) NH-T269, -C (O) NT270T271, -O-T272, -O (-T273-O) _v -H (v = 1, 2, 3, 4, 5), -O (-T274-O) _v -T275 (v = 1, 2, 3, 4, 5), -OC (O) -T276, -OC (O) -O-T277, -OC (O) -NHT278, -O-C (O)- NT279T280, -OP (O) (OT281) (OT282), -OSi (T283) (T284) (T285), -OS (O ₂ ) -T286, -NHC (O) -T287, -NT288C (O) -T289, -NH-C (O) -O-T290, -NH-C (O) -NH-T291, -NH-C (O ) -NT292T293, -NT294-C (O) -O-T295, -NT296-C (O) -NH-T297, -NT298-C (O) -NT299T300, -NHS (O ₂ ) -T301, -NT302S (O ₂ ) -T303, -S-T304, -S (O) -T305, -S (O ₂ ) -T306, -S (O ₂ ) NH-T307, -S (O ₂ ) NT308T309, -S (O ₂ ) O-T310, -P (O) (OT311) (OT312), -Si (T313) (T314) (T315) ";
At that time, T264, T265, T266, T267, T268, T269, T270, T271, T272, T273, T274, T275, T276, T277, T278, T279, T280, T281, T282, T283, T284, T285, T286, T287 T288, T289, T290, T291, T292, T293, T294, T295, T296, T297, T298, T299, T300, T301, T302, T303, T304, T305, T306, T307, T308, T309, T310, T311, T312 , T313, T314, T315 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T270, T271 and / or T279, T280 and / or T292, T293 and / or T299, T300 and / or T308, T309 may be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT316, -NT317T318, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T319, -C (O) O-T320, -C (O) NH-T321, -C (O) NT322T323, -O-T324, -O (-T325-O) _w -H (w = 1, 2, 3, 4, 5), -O (-T326-O) _w -T327 (w = 1, 2, 3, 4, 5), -OC (O) -T328, -OC (O) -O-T329, -OC (O) -NHT330, -O-C (O)- NT331T332, -OP (O) (OT333) (OT334), -OSi (T335) (T336) (T337), -OS (O ₂ ) -T338, -NHC (O) -T339, -NT340C (O) -T341, -NH-C (O) -O-T342, -NH-C (O) -NH-T343, -NH-C (O ) -NT344T345, -NT346-C (O) -O-T347, -NT348-C (O) -NH-T349, -NT350-C (O) -NT351T352, -NHS (O ₂ ) -T353, -NT354S (O ₂ ) -T355, -S-T356, -S (O) -T357, -S (O ₂ ) -T358, -S (O ₂ ) NH-T359, -S (O ₂ ) NT360T361, -S (O ₂ ) O-T362T, -P (O) (OT363) (OT364), -Si (T365) (T366) (T367) ";
At that time, T316, T317, T318, T319, T320, T321, T322, T323, T324, T325, T326, T327, T328, T329, T330, T331, T332, T333, T334, T335, T336, T337, T338, T339 , T340, T341, T342, T343, T344, T345, T346, T347, T348, T349, T350, T351, T352, T353, T354, T355, T356, T357, T358, T359, T360, T361, T362, T363 , T365, T366, T367 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T322, T323 and / or T331, T332 and / or T344, T345 and / or T351, T352 and / or T360, T361 can be taken together to form a “heterocyclyl”;
(B) -NZ26Z27,
In this case, one or both groups Z26, Z27 of the groups Z26, Z27 are selected independently of one another from the group consisting of:
(1) "-C (Y4) NZ28Z29, -C (= NZ30) -Z31";
Y4 is then selected from the group consisting of “O, S, ═NH, ═NZ32” independently of each other;
However, at least one of the groups Z28, Z29 and at least one of the groups Z30, Z31 are selected from the group consisting of:
(I) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl";
However, the said substituents of the substituent group (I) are further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "C ₉ ~ C ₃₀ -Alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, -NT368T369, -NHC (O) -cycloalkylalkyl, -NHC (O) -heterocyclylalkyl, -NT370C (O) -T371, -NH- C (O) -O-T372, -NH-C (O) -NH-T373, -NH-C (O) -NT374T375, -NT376-C (O) -O-T377, -NT378-C (O) -NH-T379, -NT380-C (O) -NT381T382, -NHS (O ₂ ) -Cycloalkylalkyl, -NHS (O ₂ ) -Heterocyclylalkyl, -NT383S (O ₂ ) -T384, -O-T385, -O (-T386-O) _x -T387 (x = 1, 2, 3, 4, 5), -O (-T388-O) _x -H (x = 1, 2, 3, 4, 5), -OC (O) -cycloalkylalkyl, -OC (O) -heterocyclylalkyl, -OC (O) -O-T389, -OC (O) -NHT390, -O-C (O) -NT391T392, -OS (O ₂ ) -Cycloalkylalkyl, -OS (O ₂ ) -Heterocyclylalkyl, -OP (O) (OT393) (OT394), -OSi (T395) (T396) (T397), -CHO, -C (O) -cycloalkyl, -C (O) -heterocyclyl,- C (O) -cycloalkylalkyl, -C (O) -heterocyclylalkyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -S-cycloalkylalkyl, -S-heterocyclylalkyl, -S-arylalkyl, -S-heteroarylalkyl, -S (O) -cycloalkyl, -S (O) -heterocyclyl, -S (O) -heteroaryl, -S (O) -cycloalkylalkyl,- S (O) -heterocyclylalkyl, -S (O) -arylalkyl, -S (O) -heteroarylalkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Heterocyclylalkyl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) NH-cycloalkyl, -S (O ₂ ) NH-heterocyclyl, -S (O ₂ ) NH-cycloalkylalkyl, -S (O ₂ ) NH-heterocyclylalkyl, -S (O ₂ ) NH-heteroarylalkyl, -S (O ₂ ) NT398T399, -S (O ₂ ) O-cycloalkyl, -S (O ₂ ) O-heterocyclyl, -S (O ₂ ) O-heteroaryl, -S (O ₂ ) O-cycloalkylalkyl, -S (O ₂ ) O-heterocyclylalkyl, -S (O ₂ ) O-heteroarylalkyl, -P (O) (OH) ₂ , -P (O) (OT400) (OT401), -Si (T402) (T403) (T404) ";
However, in addition, “—N (alkyl) ₂ ","-C (O) N (alkyl) ₂ ","-C (O) N (cycloalkyl) ₂ ","-C (O) N (aryl) ₂ ","-C (O) N (heteroaryl) ₂ "Is further substituted by at least one substituent selected from the following substituent group (ii);
At that time, T368, T369, T370, T371, T372, T373, T374, T375, T376, T377, T378, T379, T380, T381, T382, T383, T384, T385, T386, T387, T388, T389, T390, T39 , T392, T393, T394, T395, T396, T397, T398, T399, T400, T401, T402, T403, T404 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T374, T375 and / or T381, T382 and / or T391, T392 and / or T398, T399 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT405, -NT406T407, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T408, -C (O) O-T409, -C (O) NH-T410, -C (O) NT411T412, -O-T413, -O (-T414-O) _y -H (y = 1, 2, 3, 4, 5), -O (-T415-O) _y -T416 (y = 1, 2, 3, 4, 5), -OC (O) -T417, -OC (O) -O-T418, -OC (O) -NHT419, -O-C (O)- NT420T421, -OP (O) (OT422) (OT423), -OSi (T424) (T425) (T426), -OS (O ₂ ) -T427, -NHC (O) -T428, -NT429C (O) -T430, -NH-C (O) -O-T431, -NH-C (O) -NH-T432, -NH-C (O ) -NT433T434, -NT435-C (O) -O-T436, -NT437-C (O) -NH-T438, -NT439-C (O) -NT440T441, -NHS (O ₂ ) -T442, -NT443S (O ₂ ) -T444, -S-T445, -S (O) -T446, -S (O ₂ ) -T447, -S (O ₂ ) NH-T448, -S (O ₂ ) NT449T450, -S (O ₂ ) O-T451, -P (O) (OT452) (OT453), -Si (T454) (T455) (T456) ";
At that time, T405, T406, T407, T408, T409, T410, T411, T412, T413, T414, T415, T416, T417, T418, T419, T420, T421, T422, T423, T424, T425, T426, T427, T428 , T429, T430, T431, T432, T433, T434, T435, T436, T437, T438, T439, T440, T441, T442, T443, T444, T445, T446, T447, T448, T449, T450, T451, T452 , T454, T455, T456 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T411, T412 and / or T420, T421 and / or T433, T434 and / or T440, T441 and / or T449, T450 can be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT457, -NT458T459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T460, -C (O) O-T461, -C (O) NH-T462, -C (O) NT463T464, -O-T465, -O (-T466-O) _z -H (z = 1, 2, 3, 4, 5), -O (-T467-O) _z -T468 (z = 1, 2, 3, 4, 5), -OC (O) -T469, -OC (O) -O-T470, -OC (O) -NHT471, -O-C (O)- NT472T473, -OP (O) (OT474) (OT475), -OSi (T476) (T477) (T478), -OS (O ₂ ) -T479, -NHC (O) -T480, -NT481C (O) -T482, -NH-C (O) -O-T483, -NH-C (O) -NH-T484, -NH-C (O ) -NT485T486, -NT487-C (O) -O-T488, -NT489-C (O) -NH-T490, -NT491-C (O) -NT492T493, -NHS (O ₂ ) -T494, -NT495S (O ₂ ) -T496, -S-T497, -S (O) -T498, -S (O ₂ ) -T499, -S (O ₂ ) NH-T500, -S (O ₂ ) NT501T502, -S (O ₂ ) O-T503, -P (O) (OT504) (OT505), -Si (T506) (T507) (T508) ";
At that time, T457, T458, T459, T460, T461, T462, T463, T464, T465, T466, T467, T468, T469, T470, T471, T472, T473, T474, T475, T476, T477, T478, T479, T479 , T481, T482, T483, T484, T485, T486, T487, T488, T489, T490, T491, T492, T493, T494, T495, T496, T497, T498, T499, T500, T501, T502, T503, T504 , T506, T507, T508 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T463, T464 and / or T472, T473 and / or T485, T486 and / or T492, T493 and / or T501, T502 can each be taken together to form a "heterocyclyl";
Or
However, at least one of the groups Z28, Z29 and at least one of the groups Z30, Z31 are selected from the group consisting of:
(II) "C ₉ ~ C ₃₀ -Alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -arylalkyl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl,- C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In that case, in some cases, the substituents of the substituent group (II) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT509, -NT510T511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T512, -C (O) O-T513, -C (O) NH-T514, -C (O) NT515T516, -O-T517, -O (-T518-O) _r -H (a = 1, 2, 3, 4, 5), -O (-T519-O) _a -T520 (a = 1, 2, 3, 4, 5), -OC (O) -T521, -OC (O) -O-T522, -OC (O) -NHT523, -O-C (O)- NT524T525, -OP (O) (OT526) (OT527), -OSi (T528) (T529) (T530), -OS (O ₂ ) -T531, -NHC (O) -T532, -NT533C (O) -T534, -NH-C (O) -O-T535, -NH-C (O) -NH-T536, -NH-C (O ) -NT537T538, -NT539-C (O) -O-T540, -NT541-C (O) -NH-T542, -NT543-C (O) -NT544T545, -NHS (O ₂ ) -T546, -NT547S (O ₂ ) -T548, -S-T549, -S (O) -T550, -S (O ₂ ) -T551, -S (O ₂ ) NH-T552, -S (O ₂ ) NT553T554, -S (O ₂ ) O-T555, -P (O) (OT556) (OT557), -Si (T558) (T559) (T560) ";
At that time, T509, T510, T511, T512, T513, T514, T515, T516, T517, T518, T519, T520, T521, T522, T523, T524, T525, T526, T527, T528, T529, T530, T531, T532 , T533, T534, T535, T536, T537, T538, T539, T540, T541, T542, T543, T544, T545, T546, T547, T548, T549, T550, T551, T552, T553, T554, T555, T556 , T558, T559, T560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T515, T516 and / or T524, T525 and / or T537, T538 and / or T544, T545 and / or T553, T554 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT561, -NT562T563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T564, -C (O) O-T565, -C (O) NH-T566, -C (O) NT567T568, -O-T569, -O (-T570-O) _b -H (b = 1, 2, 3, 4, 5), -O (-T571-O) _b -T572 (b = 1, 2, 3, 4, 5), -OC (O) -T573, -OC (O) -O-T574, -OC (O) -NHT575, -O-C (O)- NT576T577, -OP (O) (OT578) (OT579), -OSi (T580) (T581) (T582), -OS (O ₂ ) -T583, -NHC (O) -T584, -NT585C (O) -T586, -NH-C (O) -O-T587, -NH-C (O) -NH-T588, -NH-C (O ) -NT589T590, -NT591-C (O) -O-T592, -NT593-C (O) -NH-T594, -NT595-C (O) -NT596T597, -NHS (O ₂ ) -T598, -NT599S (O ₂ ) -T600, -S-T601, -S (O) -T602, -S (O ₂ ) -T603, -S (O ₂ ) NH-T604, -S (O ₂ ) NT605T606, -S (O ₂ ) O-T607, -P (O) (OT608) (OT609), -Si (T610) (T611) (T612) ";
At that time, T561, T562, T563, T564, T565, T566, T567, T568, T569, T570, T571, T572, T573, T574, T575, T576, T577, T578, T579, T580, T581, T582, T583, T583 T585, T586, T587, T588, T589, T590, T591, T592, T593, T594, T595, T596, T597, T598, T599, T600, T601, T602, T603, T604, T605, T606, T607, T608 , T610, T611, T612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T567, T568 and / or T576, T577 and / or T589, T590 and / or T596, T597 and / or T605, T606 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT613, -NT614T615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T616, -C (O) O-T617, -C (O) NH-T618, -C (O) NT619T620, -O-T621, -O (-T622-O) _c -H (c = 1, 2, 3, 4, 5), -O (-T623-O) _c -T624 (c = 1, 2, 3, 4, 5), -OC (O) -T625, -OC (O) -O-T626, -OC (O) -NHT627, -O-C (O)- NT628T629, -OP (O) (OT630) (OT631), -OSi (T632) (T633) (T634), -OS (O ₂ ) -T635, -NHC (O) -T636, -NT637C (O) -T638, -NH-C (O) -O-T639, -NH-C (O) -NH-T640, -NH-C (O ) -NT641T642, -NT643-C (O) -O-T644, -NT645-C (O) -NH-T646, -NT647-C (O) -NT648T649, -NHS (O ₂ ) -T650, -NT651S (O ₂ ) -T652, -S-T653, -S (O) -T654, -S (O ₂ ) -T655, -S (O ₂ ) NH-T656, -S (O ₂ ) NT657T658, -S (O ₂ ) O-T659, -P (O) (OT660) (OT661), -Si (T662) (T663) (T664) ";
At that time, T613, T614, T615, T616, T617, T618, T619, T620, T621, T622, T623, T624, T625, T626, T627, T628, T629, T630, T631, T632, T633, T636, T636, T636 , T637, T638, T639, T640, T641, T642, T643, T644, T645, T646, T647, T648, T649, T650, T651, T652, T653, T654, T655, T656, T657, T658, T659, T660 , T662, T663, T664 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T619, T620 and / or T628, T629 and / or T641, T642 and / or T648, T649 and / or T657, T658 may each be taken together to form a “heterocyclyl”;
as well as
One of the groups Z28, Z29, independently of each other, is selected from the group consisting of: or neither of the groups Z28, Z29 is selected from the group consisting of:
(III) "hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C (O) -alkyl, -C (O) -aryl, -C (O) -heteroaryl";
In this case, the substituents of the substituent group (III) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT665, -NT666T667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T668, -C (O) O-T669, -C (O) NH-T670, -C (O) NT671T672, -O-T673, -O (-T674-O) _d -H (d = 1, 2, 3, 4, 5), -O (-T675-O) _d -T676 (d = 1, 2, 3, 4, 5), -OC (O) -T677, -OC (O) -O-T678, -OC (O) -NHT679, -O-C (O)- NT680T681, -OP (O) (OT682) (OT683), -OSi (T684) (T685) (T686), -OS (O ₂ ) -T687, -NHC (O) -T688, -NT689C (O) -T690, -NH-C (O) -O-T691, -NH-C (O) -NH-T692, -NH-C (O ) -NT693T694, -NT695-C (O) -O-T696, -NT697-C (O) -NH-T698, -NT699-C (O) -NT700T701, -NHS (O ₂ ) -T702, -NT703S (O ₂ ) -T704, -S-T705, -S (O) -T706, -S (O ₂ ) -T707, -S (O ₂ ) NH-T708, -S (O ₂ ) NT709T710, -S (O ₂ ) O-T711, -P (O) (OT712) (OT713), -Si (T714) (T715) (T716) ";
At that time, T665, T666, T667, T668, T669, T670, T671, T672, T673, T674, T675, T676, T677, T678, T679, T680, T681, T682, T683, T684, T685, T686, T687, T687 T689, T690, T691, T692, T693, T694, T695, T696, T697, T698, T699, T700, T701, T702, T703, T704, T705, T706, T707, T708, T709, T710, T711, T712 , T714, T715, T716 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T671, T672 and / or T680, T681 and / or T693, T694 and / or T700, T701 and / or T709, T710 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT717, -NT718T719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T720, -C (O) O-T721, -C (O) NH-T722, -C (O) NT723T724, -O-T725, -O (-T726-O) _e -H (e = 1, 2, 3, 4, 5), -O (-T727-O) _e -T728 (e = 1, 2, 3, 4, 5), -OC (O) -T729, -OC (O) -O-T730, -OC (O) -NHT731, -O-C (O)- NT732T733, -OP (O) (OT734) (OT735), -OSi (T736) (T737) (T738), -OS (O ₂ ) -T739, -NHC (O) -T740, -NT741C (O) -T742, -NH-C (O) -O-T743, -NH-C (O) -NH-T744, -NH-C (O ) -NT745T746, -NT747-C (O) -O-T748, -NT749-C (O) -NH-T750, -NT751-C (O) -NT752T753, -NHS (O ₂ ) -T754, -NT755S (O ₂ ) -T756, -S-T757, -S (O) -T758, -S (O ₂ ) -T759, -S (O ₂ ) NH-T760, -S (O ₂ ) NT761T762, -S (O ₂ ) O-T763, -P (O) (OT764) (OT765), -Si (T766) (T767) (T768) ";
At that time, T717, T718, T719, T720, T721, T722, T723, T724, T725, T726, T727, T728, T729, T730, T731, T732, T733, T734, T735, T736, T737, T738, T739, T7 T741, T742, T743, T744, T745, T746, T747, T748, T749, T750, T751, T752, T753, T754, T755, T756, T757, T758, T759, T760, T761, T762, T763, T764 , T766, T767, T768 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T723, T724 and / or T732, T733 and / or T745, T746 and / or T752, T753 and / or T761, T762 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be substituted with at least one substituent selected from the group consisting of the same or different, independent of each other:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT769, -NT770T771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T772, -C (O) O-T773, -C (O) NH-T774, -C (O) NT775T776, -O-T777, -O (-T778-O) _f -H (f = 1, 2, 3, 4, 5), -O (-T779-O) _f -T780 (f = 1, 2, 3, 4, 5), -OC (O) -T781, -OC (O) -O-T782, -OC (O) -NHT783, -O-C (O)- NT784T785, -OP (O) (OT786) (OT787), -OSi (T788) (T789) (T790), -OS (O ₂ ) -T791, -NHC (O) -T792, -NT793C (O) -T794, -NH-C (O) -O-T795, -NH-C (O) -NH-T796, -NH-C (O ) -NT797T798, -NT799-C (O) -O-T800, -NT801-C (O) -NH-T802, -NT803-C (O) -NT804T805, -NHS (O ₂ ) -T806, -NT807S (O ₂ ) -T808, -S-T809, -S (O) -T810, -S (O ₂ ) -T811, -S (O ₂ ) NH-T812, -S (O ₂ ) NT813T814, -S (O ₂ ) O-T815, -P (O) (OT816) (OT817), -Si (T818) (T819) (T820) ";
At that time, T769, T770, T771, T772, T773, T774, T775, T776, T777, T778, T779, T780, T781, T782, T783, T784, T785, T786, T787, T788, T789, T790, T791, 792 T793, T794, T795, T796, T797, T798, T799, T800, T801, T802, T803, T804, T805, T806, T807, T808, T809, T810, T811, T812, T813, T814, T815, T816 , T818, T819, T820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T775, T776 and / or T784, T785 and / or T797, T798 and / or T804, T805 and / or T813, T814 may each be taken together to form a “heterocyclyl”;
(2) "-C (Y5) NZ33-Y6-Z34";
In this case, Y5 and T6 are selected from the group consisting of “O, S, ═NH, ═NZ35” independently of each other;
Z33, Z34, Z35 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In this case, the substituents of the substituent group (II) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT821, -NT822T823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T824, -C (O) O-T825, -C (O) NH-T826, -C (O) NT827T828, -O-T829, -O (-T830-O) _g -H (g = 1, 2, 3, 4, 5), -O (-T831-O) _g -T832 (g = 1, 2, 3, 4, 5), -OC (O) -T833, -OC (O) -O-T834, -OC (O) -NHT835, -O-C (O)- NT836T837, -OP (O) (OT838) (OT839), -OSi (T840) (T841) (T842), -OS (O ₂ ) -T843, -NHC (O) -T844, -NT845C (O) -T846, -NH-C (O) -O-T847, -NH-C (O) -NH-T848, -NH-C (O ) -NT849T850, -NT851-C (O) -O-T852, -NT853-C (O) -NH-T854, -NT855-C (O) -NT856T857, -NHS (O ₂ ) -T858, -NT859S (O ₂ ) -T860, -S-T861, -S (O) -T862, -S (O ₂ ) -T863, -S (O ₂ ) NH-T864, -S (O ₂ ) NT865T866, -S (O ₂ ) O-T867, -P (O) (OT868) (OT869), -Si (T870) (T871) (T872) ";
At that time, T821, T822, T823, T824, T825, T826, T827, T828, T829, T830, T831, T832, T833, T834, T835, T836, T837, T838, T833, T840, T841, T842, T843, T843 T845, T846, T847, T848, T849, T850, T851, T852, T853, T854, T855, T856, T857, T858, T859, T860, T861, T862, T863, T864, T865, T866, T867, T868 , T870, T871, T872 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T827, T828 and / or T836, T837 and / or T849, T850 and / or T856, T857 and / or T865, T866 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT873, -NT874T875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T876, -C (O) O-T877, -C (O) NH-T878, -C (O) NT879T880, -O-T881, -O (-T882-O) _h -H (h = 1, 2, 3, 4, 5), -O (-T883-O) _h -T884 (h = 1, 2, 3, 4, 5), -OC (O) -T885, -OC (O) -O-T886, -OC (O) -NHT887, -O-C (O)- NT888T889, -OP (O) (OT890) (OT891), -OSi (T892) (T893) (T894), -OS (O ₂ ) -T895, -NHC (O) -T896, -NT897C (O) -T898, -NH-C (O) -O-T899, -NH-C (O) -NH-T900, -NH-C (O ) -NT901T902, -NT903-C (O) -O-T904, -NT905-C (O) -NH-T906, -NT907-C (O) -NT908T909, -NHS (O ₂ ) -T910, -NT911S (O ₂ ) -T912, -S-T913, -S (O) -T914, -S (O ₂ ) -T915, -S (O ₂ ) NH-T916, -S (O ₂ ) NT917T918, -S (O ₂ ) O-T919, -P (O) (OT920) (OT921), -Si (T922) (T923) (T924) ";
At that time, T873, T874, T875, T876, T877, T878, T879, T880, T881, T882, T883, T884, T885, T886, T887, T888, T889, T890, T891, T892, T893, T894, T895, T895 T897, T898, T899, T900, T901, T902, T903, T904, T905, T906, T907, T908, T909, T910, T911, T912, T913, T914, T915, T916, T917, T918, T919, T920 , T922, T923, T924 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T879, T880 and / or T888, T889 and / or T901, T902 and / or T908, T909 and / or T917, T918 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT925, -NT926T927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T928, -C (O) O-T929, -C (O) NH-T930, -C (O) NT931T932, -O-T933, -O (-T934-O) _i -H (i = 1, 2, 3, 4, 5), -O (-T935-O) _i -T936 (i = 1, 2, 3, 4, 5), -OC (O) -T937, -OC (O) -O-T938, -OC (O) -NHT939, -O-C (O)- NT940T941, -OP (O) (OT942) (OT943), -OSi (T944) (T945) (T946), -OS (O ₂ ) -T947, -NHC (O) -T948, -NT949C (O) -T950, -NH-C (O) -O-T951, -NH-C (O) -NH-T952, -NH-C (O ) -NT953T954, -NT955-C (O) -O-T956, -NT957-C (O) -NH-T958, -NT959-C (O) -NT960T961, -NHS (O ₂ ) -T962, -NT963S (O ₂ ) -T964, -S-T965, -S (O) -T966, -S (O ₂ ) -T967, -S (O ₂ ) NH-T968, -S (O ₂ ) NT969T970, -S (O ₂ ) O-T971, -P (O) (OT972) (OT973), -Si (T974) (T975) (T976) ";
In that case, T925, T926, T927, T929, T929, T930, T931, T932, T933, T934, T935, T936, T937, T938, T939, T940, T941, T942, T943, T944, T945, T946, T947, T948 , T949, T950, T951, T952, T953, T954, T955, T95, T957, T958, T959, T960, T961, T962, T963, T964, T965, T966, T967, T968, T969, T970, T971, T972 , T974, T975, T976 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T931, T932 and / or T940, T941 and / or T953, T954 and / or T960, T961 and / or T969, T970 can each be taken together to form a “heterocyclyl”;
as well as
One of the groups Z26, Z27, independently of one another, is selected from the group consisting of: or neither of the groups Z26, Z27 is selected from the group consisting of:
(3) "Hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -C (Y7) NZ36Z37, -C (= NZ38) -Z39, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
Y7 is selected from the group consisting of “O, S, ═NH, ═NZ40” independently of each other;
In so doing, the groups Z36, Z37, Z38, Z39, Z40 are selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In that case, depending on the case, the substituents of the substituent group (3) and / or the substituent group (I) are at least one substituent selected from the group consisting of the following, the same or different, independently of each other: It may be further substituted by a group:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT977, -NT978T979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T980, -C (O) O-T981, -C (O) NH-T982, -C (O) NT983T984, -O-T985, -O (-T986-O) _j -H (j = 1, 2, 3, 4, 5), -O (-T987-O) _j -T988 (j = 1, 2, 3, 4, 5), -OC (O) -T989, -OC (O) -O-T990, -OC (O) -NHT991, -O-C (O)- NT992T993, -OP (O) (OT994) (OT995), -OSi (T996) (T997) (T998), -OS (O ₂ ) -T999, -NHC (O) -T1000, -NT1001C (O) -T1002, -NH-C (O) -O-T1003, -NH-C (O) -NH-T1004, -NH-C (O ) -NT1005T1006, -NT1007-C (O) -O-T1008, -NT1009-C (O) -NH-T1010, -NT1011-C (O) -NT1012T1013, -NHS (O ₂ ) -T1014, -NT1015S (O ₂ ) -T1016, -S-T1017, -S (O) -T1018, -S (O ₂ ) -T1019, -S (O ₂ ) NH-T1020, -S (O ₂ ) NT1021T1022, -S (O ₂ ) O-T1023, -P (O) (OT1024) (OT1025), -Si (T1026) (T1027) (T1028) ";
In that case, T977, T978, T979, T980, T981, T982, T983, T984, T985, T986, T987, T988, T989, T990, T991, T992, T993, T994, T995, T996, T997, T998, T999, 1000 T1001, T1002, T1003, T1004, T1005, T1006, T1007, T1008, T1009, T1010, T1011, T1012, T1013, T1014, T1015, T1016, T1017, T1018, T1019, T1020, T1021, T1022, T1023, T1024 , T1026, T1027, T1028 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T983, T984 and / or T992, T993 and / or T1005, T1006 and / or T1012, T1013 and / or T1021, T1022 may each be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1029, -NT1030T1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1032, -C (O) O-T1033, -C (O) NH-T1034, -C (O) NT1035T1036, -O-T1037, -O (-T1038-O) _k -H (k = 1, 2, 3, 4, 5), -O (-T1039-O) _k -T1040 (k = 1, 2, 3, 4, 5), -OC (O) -T1041, -OC (O) -O-T1042, -OC (O) -NHT1043, -O-C (O)- NT1044T1045, -OP (O) (OT1046) (OT1047), -OSi (T1048) (T1049) (T1050), -OS (O ₂ ) -T1051, -NHC (O) -T1052, -NT1053C (O) -T1054, -NH-C (O) -O-T1055, -NH-C (O) -NH-T1056, -NH-C (O ) -NT1057T1058, -NT1059-C (O) -O-T1060, -NT1061-C (O) -NH-T1062, -NT1063-C (O) -NT1064T1065, -NHS (O ₂ ) -T1066, -NT1067S (O ₂ ) -T1068, -S-T1069, -S (O) -T1070, -S (O ₂ ) -T1071, -S (O ₂ ) NH-T1072, -S (O ₂ ) NT1073T1074, -S (O ₂ ) O-T1075, -P (O) (OT1076) (OT1077), -Si (T1078) (T1079) (T1080) ";
At that time, T1029, T1030, T1031, T1032, T1033, T1034, T1035, T1036, T1037, T1038, T1039, T1040, T1041, T1042, T1043, T1044, T1045, T1046, T1047, T1048, T1049, T1050, T1051, T1052, . , T1078, T1079, T1080 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1035, T1036 and / or T1044, T1045 and / or T1057, T1058, and / or T1064, T1065, and / or T1073, T1074 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1081, -NT1082T1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1084, -C (O) O-T1085, -C (O) NH-T1086, -C (O) NT1087T1088, -O-T1089, -O (-T1090-O) _l -H (l = 1, 2, 3, 4, 5), -O (-T1091-O) _l -T1092 (l = 1, 2, 3, 4, 5), -OC (O) -T1093, -OC (O) -O-T1094, -OC (O) -NHT1095, -O-C (O)- NT1096T1097, -OP (O) (OT1098) (OT1099), -OSi (T1100) (T1101) (T1102), -OS (O ₂ ) -T1103, -NHC (O) -T1104, -NT1105C (O) -T1106, -NH-C (O) -O-T1107, -NH-C (O) -NH-T1108, -NH-C (O ) -NT1109T1110, -NT1111-C (O) -O-T1112, -NT1113-C (O) -NH-T1114, -NT1115-C (O) -NT1116T1117, -NHS (O ₂ ) -T1118, -NT1119S (O ₂ ) -T1120, -S-T1121, -S (O) -T1122, -S (O ₂ ) -T1123, -S (O ₂ ) NH-T1124, -S (O ₂ ) NT1125T1126, -S (O ₂ ) O-T1127, -P (O) (OT1128) (OT1129), -Si (T1130) (T1131) (T1132) ";
At that time, T1081, T1082, T1083, T1084, T1085, T1086, T1087, T1088, T1089, T1090, T1091, T1092, T1093, T1094, T1095, T1096, T1097, T1098, T1099, T1100, T1101, T1102, T1103, T1104 , T1105, T1106, T1107, T1108, T1109, T1110, T1111, T1112, T1113, T1114, T1115, T1116, T1117, T1118, T1119, T1120, T1121, T1122, T1123, T1124, T1125, T1126, T1127, T1128 , T1130, T1131, T1132, independently of one another, are “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1087, T1088 and / or T1096, T1097 and / or T1109, T1110 and / or T1116, T1117 and / or T1125, T1126 may each be taken together to form a "heterocyclyl";
as well as
One of the groups Z1, Z2, independently of each other, is selected from the group consisting of: or neither of the groups Z1, Z2 is selected from the group consisting of:
(C) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1133, -NT1134T1135, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ -C (O) -T1136, -C (O) O-T1137, -C (O) NH-T1138, -C (O) NT1139T1140, -O-T1141, -O (-T1142-O) _m -H (m = 1, 2, 3, 4, 5), -O (-T1143-O) _m -T1144 (m = 1, 2, 3, 4, 5), -OC (O) -T1145, -OC (O) -O-T1146, -OC (O) -NHT1147, -O-C (O)- NT1148T1149, -OP (O) (OT1150) (OT1151), -OSi (T1152) (T1153) (T1154), -OS (O ₂ ) -T1155, -NHC (O) -T1156, -NT1157C (O) -T1158, -NH-C (O) -O-T1159, -NH-C (O) -NH-T1160, -NH-C (O ) -NT1161T1162, -NT1163-C (O) -O-T1164, -NT1165-C (O) -NH-T1166, -NT1167-C (O) -NT1168T1169, -NHS (O ₂ ) -T1170, -NT1171S (O ₂ ) -T1172, -S-T1173, -S (O) -T1174, -S (O ₂ ) -T1175, -S (O ₂ ) NH-T1176, -S (O ₂ ) NT1177T1178, -S (O ₂ ) O-T1179, -P (O) (OT1180) (OT1181), -Si (T1182) (T1183) (T1184) ";
At that time, T1133, T1134, T1135, T1136, T1137, T1138, T1139, T1140, T1141, T1142, T1143, T1144, T1145, T1146, T1147, T1148, T1149, T1150, T1151, T1152, T1153, T1156, T1156, T1156, T1157, T1158, T1159, T1160, T1161, T1162, T1163, T1164, T1165, T1166, T1167, T1168, T1169, T1170, T1171, T1172, T1173, T1174, T1175, T1176, T1177, T1178, T1179, T1180 , T1182, T1183, T1184 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1139, T1140 and / or T1148, T1149 and / or T1161, T1162 and / or T1168, T1169 and / or T1177, T1178 may each be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (c) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1185, -NT1186T1187, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1188, -C (O) O-T1189, -C (O) NH-T1190, -C (O) NT1191T1192, -O-T1193, -O (-T1194-O) _n -H (n = 1, 2, 3, 4, 5), -O (-T1195-O) _n -T1196 (n = 1, 2, 3, 4, 5), -OC (O) -T1197, -OC (O) -O-T1198, -OC (O) -NHT1199, -O-C (O)- NT1200T1201, -OP (O) (OT1202) (OT1203), -OSi (T1204) (T1205) (T1206), -OS (O ₂ ) -T1207, -NHC (O) -T1208, -NT1209C (O) -T1210, -NH-C (O) -O-T1211, -NH-C (O) -NH-T1212, -NH-C (O ) -NT1213T1214, -NT1215-C (O) -O-T1216, -NT1217-C (O) -NH-T1218, -NT1219-C (O) -NT1220T1221, -NHS (O ₂ ) -T1222, -NT1223S (O ₂ ) -T1224, -S-T1225, -S (O) -T1226, -S (O ₂ ) -T1227, -S (O ₂ ) NH-T1228, -S (O ₂ ) NT1229T1230, -S (O ₂ ) O-T1231, -P (O) (OT1232) (OT1233), -Si (T1234) (T1235) (T1236) ";
At that time, T1185, T1186, T1187, T1188, T1189, T1190, T1191, T1192, T1193, T1194, T1195, T1196, T1197, T1198, T1199, T1200, T1201, T1202, T1203, T1204, T1205, T1206, T1207, T1208 , T1209, T1210, T1211, T1212, T1213, T1214, T1215, T1216, T1217, T1218, T1219, T1220, T1221, T1222, T1223, T1224, T1225, T1226, T1227, T1228, T1229, T1230, T1231, 3312 , T1234, T1235, and T1236 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1191, T1192 and / or T1200, T1201, and / or T1213, T1214 and / or T1220, T1221 and / or T1229, T1230 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be substituted with at least one substituent selected from the group consisting of the following, independently or identically:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1237, -NT1238T1239, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1240, -C (O) O-T1241, -C (O) NH-T1242, -C (O) NT1243T1244, -O-T1245, -O (-T1246-O) _o -H (o = 1, 2, 3, 4, 5), -O (-T1247-O) _o -T1248 (o = 1, 2, 3, 4, 5), -OC (O) -T1249, -OC (O) -O-T1250, -OC (O) -NHT1251, -O-C (O)- NT1252T1253, -OP (O) (OT1254) (OT1255), -OSi (T1256) (T1257) (T1258), -OS (O ₂ ) -T1259, -NHC (O) -T1260, -NT1261C (O) -T1262, -NH-C (O) -O-T1263, -NH-C (O) -NH-T1264, -NH-C (O ) -NT1265T1266, -NT1267-C (O) -O-T1268, -NT1269-C (O) -NH-T1270, -NT1271-C (O) -NT1272T1273, -NHS (O ₂ ) -T1274, -NT1275S (O ₂ ) -T1276, -S-T1277, -S (O) -T1278, -S (O ₂ ) -T1279, -S (O ₂ ) NH-T1280, -S (O ₂ ) NT1281T1282, -S (O ₂ ) O-T1283, -P (O) (OT1284) (OT1285), -Si (T1286) (T1287) (T1288) ";
At that time, T1237, T1238, T1239, T1240, T1241, T1242, T1243, T1244, T1245, T1246, T1247, T1248, T1249, T1250, T1251, T1252, T1253, T1254, T1255, T1256, T1257, T1258, T1258, T1259, T1259 , T1261, T1262, T1263, T1264, T1265, T1266, T1267, T1268, T1269, T1270, T1271, T1272, T1273, T1274, T1275, T1276, T1277, T1278, T1279, T1280, T1281, T1282, T1283, T1284 , T1286, T1287, T1288 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1243, T1244 and / or T1252, T1253 and / or T1265, T1266 and / or T1272, T1273 and / or T1281, T1282 may be taken together to form a “heterocyclyl”;
(D) -NZ41Z42,
The groups Z41, Z42 are then selected from the group consisting of:
(1) "Alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl ";
In this case, the substituents of the substituent group (1) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1289, -NT1290T1291, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1292, -C (O) O-T1293, -C (O) NH-T1294, -C (O) NT1295T1296, -O-T1297, -O (-T1298-O) _rr -H (rr = 1, 2, 3, 4, 5), -O (-T1299-O) _rr -T1300 (rr = 1, 2, 3, 4, 5), -OC (O) -T1301, -OC (O) -O-T1302, -OC (O) -NHT1303, -O-C (O)- NT1304T1305, -OP (O) (OT1306) (OT1307), -OSi (T1308) (T1309) (T1310), -OS (O ₂ ) -T1311, -NHC (O) -T1312, -NT1313C (O) -T1314, -NH-C (O) -O-T1315, -NH-C (O) -NH-T1316, -NH-C (O ) -NT1317T1318, -NT1319-C (O) -O-T1320, -NT1321-C (O) -NH-T1322, -NT1323-C (O) -NT1324T1325, -NHS (O ₂ ) -T1326, -NT1327S (O ₂ ) -T1328, -S-T1329, -S (O) -T1330, -S (O ₂ ) -T1331, -S (O ₂ ) NH-T1332, -S (O ₂ ) NT1333T1334, -S (O ₂ ) O-T1335, -P (O) (OT1336) (OT1337), -Si (T1338) (T1339) (T1340) ";
At that time, T1289, T1290, T1291, T1292, T1293, T1294, T1295, T1296, T1297, T1298, T1299, T1300, T1301, T1302, T1303, T1304, T1305, T1306, T1307, T1308, T1309, T1310, T1311, T1311 T1313, T1314, T1315, T1316, T1317, T1318, T1319, T1320, T1321, T1322, T1323, T1324, T1325, T1326, T1327, T1328, T1329, T1330, T1331, T1332, T1333, T1336, T1335, T1336 , T1338, T1339, T1340, independently of each other ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1295, T1296 and / or T1304, T1305 and / or T1317, T1318 and / or T1324, T1325 and / or T1333, T1334 may be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1341, -NT1342T1343, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1344, -C (O) O-T1345, -C (O) NH-T1346, -C (O) NT1347T1348, -O-T1349, -O (-T1350-O) _rs -H (rs = 1, 2, 3, 4, 5), -O (-T1351-O) _rs -T1352 (rs = 1, 2, 3, 4, 5), -OC (O) -T1353, -OC (O) -O-T1354, -OC (O) -NHT1355, -O-C (O)- NT1356T1357, -OP (O) (OT1358) (OT1359), -OSi (T1360) (T1361) (T1362), -OS (O ₂ ) -T1363, -NHC (O) -T1364, -NT1365C (O) -T1366, -NH-C (O) -O-T1367, -NH-C (O) -NH-T1368, -NH-C (O ) -NT1369T1370, -NT1371-C (O) -O-T1372, -NT1373-C (O) -NH-T1374, -NT1375-C (O) -NT1376T1377, -NHS (O ₂ ) -T1378, -NT1379S (O ₂ ) -T1380, -S-T1381, -S (O) -T1382, -S (O ₂ ) -T1383, -S (O ₂ ) NH-T1384, -S (O ₂ ) NT1385T1386, -S (O ₂ ) O-T1387, -P (O) (OT1388) (OT1389), -Si (T1390) (T1391) (T1392) ";
In that case, T1341, T1342, T1343, T1344, T1345, T1346, T1347, T1348, T1349, T1350, T1351, T1352, T1353, T1354, T1355, T1356, T1357, T1358, T1359, T1360, T1363, T1363, T1363, T1363 T1365, T1366, T1367, T1368, T1369, T1370, T1371, T1372, T1373, T1374, T1375, T1376, T1377, T1378, T1379, T1380, T1381, T1382, T1383, T1384, T1385, T1388, T1387, T1388 , T1390, T1391, and T1392 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1347, T1348 and / or T1356, T1357 and / or T1369, T1370 and / or T1376, T1377 and / or T1385, T1386 can each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1393, -NT1394T1395, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1396, -C (O) O-T1397, -C (O) NH-T1398, -C (O) NT1399T1400, -O-T1401, -O (-T1402-O) _rt -H (rt = 1, 2, 3, 4, 5), -O (-T1403-O) _rt -T1404 (rt = 1, 2, 3, 4, 5), -OC (O) -T1405, -OC (O) -O-T1406, -OC (O) -NHT1407, -O-C (O)- NT1408T1409, -OP (O) (OT1410) (OT1411), -OSi (T1412) (T1413) (T1414), -OS (O ₂ ) -T1415, -NHC (O) -T1416, -NT1417C (O) -T1418, -NH-C (O) -O-T1419, -NH-C (O) -NH-T1420, -NH-C (O ) -NT1421T1422, -NT1423-C (O) -O-T1424, -NT1425-C (O) -NH-T1426, -NT1427-C (O) -NT1428T1429, -NHS (O ₂ ) -T1430, -NT1431S (O ₂ ) -T1432, -S-T1433, -S (O) -T1434, -S (O ₂ ) -T1435, -S (O ₂ ) NH-T1436, -S (O ₂ ) NT1437T1438, -S (O ₂ ) O-T1439, -P (O) (OT1440) (OT1441), -Si (T1442) (T1443) (T1444) ";
At that time, T1393, T1394, T1395, T1396, T1397, T1398, T1399, T1400, T1401, T1402, T1403, T1404, T1405, T1406, T1407, T1408, T1409, T1410, T1411, T1412, T1413, T1414, T1414, T1414, T1415 , T1417, T1418, T1419, T1420, T1421, T1422, T1423, T1424, T1425, T1426, T1427, T1428, T1429, T1430, T1431, T1432, T1433, T1434, T1435, T1436, T1437, T1438, T1439, T1440 , T1442, T1443, T1444 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1399, T1400 and / or T1408, T1409 and / or T1421, T1422 and / or T1428, T1429 and / or T1437, T1438 may be taken together to form a "heterocyclyl";
(2) "-C (O) -C (O) -T1445, -S (O ₂ ) -NT1446T1447 ";
T1445, T1446, T1447 are then selected from the group consisting of the following, independently of each other:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1448, -NT1449T1450, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1451, -C (O) O-T1452, -C (O) NH-T1453, -C (O) NT1454T1455, -O-T1456, -O (-T1457-O) _ru -H (ru = 1, 2, 3, 4, 5), -O (-T1458-O) _ru -T1459 (ru = 1, 2, 3, 4, 5), -OC (O) -T1460, -OC (O) -O-T1461, -OC (O) -NHT1462, -O-C (O)- NT1463T1464, -OP (O) (OT1465) (OT1466), -OSi (T1467) (T1468) (T1469), -OS (O ₂ ) -T1470, -NHC (O) -T1471, -NT1472C (O) -T1473, -NH-C (O) -O-T1474, -NH-C (O) -NH-T1475, -NH-C (O ) -NT1476T1477, -NT1478-C (O) -O-T1479, -NT1480-C (O) -NH-T1481, -NT1482-C (O) -NT1483T1484, -NHS (O ₂ ) -T1485, -NT1486S (O ₂ ) -T1487, -S-T1488, -S (O) -T1489, -S (O ₂ ) -T1490, -S (O ₂ ) NH-T1491, -S (O ₂ ) NT1492T1493, -S (O ₂ ) O-T1494, -P (O) (OT1495) (OT1496), -Si (T1497) (T1498) (T1499) ";
At that time, T1448, T1449, T1450, T1451, T1452, T1453, T1454, T1455, T1456, T1457, T1458, T1458, T1460, T1461, T1462, T1463, T1464, T1465, T1466, T1467, T1468, T1469, T1470, T1471 . , T1497, T1498, T1499 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1454, T1455 and / or T1463, T1464 and / or T1476, T1477 and / or T1483, T1484 and / or T1492, T1493 can also be taken together to form a "heterocyclyl";
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1500, -NT1501T1502, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1503, -C (O) O-T1504, -C (O) NH-T1505, -C (O) NT1506T1507, -O-T1508, -O (-T1509-O) _rv -H (rv = 1, 2, 3, 4, 5), -O (-T1510-O) _rv -T1511 (rv = 1, 2, 3, 4, 5), -OC (O) -T1512, -OC (O) -O-T1513, -OC (O) -NHT1514, -O-C (O)- NT1515T1516, -OP (O) (OT1517) (OT1518), -OSi (T1519) (T1520) (T1521), -OS (O ₂ ) -T1522, -NHC (O) -T1523, -NT1524C (O) -T1525, -NH-C (O) -O-T1526, -NH-C (O) -NH-T1527, -NH-C (O ) -NT1528T1529, -NT1530-C (O) -O-T1531, -NT1532-C (O) -NH-T1533, -NT1534-C (O) -NT1535T1536, -NHS (O ₂ ) -T1537, -NT1538S (O ₂ ) -T1539, -S-T1540, -S (O) -T1541, -S (O ₂ ) -T1542, -S (O ₂ ) NH-T1543, -S (O ₂ ) NT1544T1545, -S (O ₂ ) O-T1546, -P (O) (OT1547) (OT1548), -Si (T1549) (T1550) (T1551) ";
At that time, T1500, T1501, T1502, T1503, T1504, T1505, T1506, T1507, T1508, T1509, T1510, T1511, T1512, T1513, T1514, T1515, T1516, T1517, T1518, T1519, T1520, T1521, T1523 T1524, T1525, T1526, T1527, T1528, T1529, T1530, T1531, T1532, T1533, T1534, T1535, T1536, T1537, T1538, T1539, T1540, T1541, T1542, T1543, T1544, T1545, T1546, T1547 , T1549, T1550, T1551 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1506, T1507 and / or T1515, T1516 and / or T1528, T1529 and / or T1535, T1536 and / or T1544, T1545 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1552, -NT1553T1554, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1555, -C (O) O-T1556, -C (O) NH-T1557, -C (O) NT1558T1559, -O-T1560, -O (-T1561-O) _rw -H (rw = 1, 2, 3, 4, 5), -O (-T1562-O) _rw -T1563 (rw = 1, 2, 3, 4, 5), -OC (O) -T1564, -OC (O) -O-T1565, -OC (O) -NHT1566, -O-C (O)- NT1567T1568, -OP (O) (OT1569) (OT1570), -OSi (T1571) (T1572) (T1573), -OS (O ₂ ) -T1574, -NHC (O) -T1558, -NT1576C (O) -T1577, -NH-C (O) -O-T1578, -NH-C (O) -NH-T1579, -NH-C (O ) -NT1580T1581, -NT1582-C (O) -O-T1583, -NT1584-C (O) -NH-T1585, -NT1586-C (O) -NT1587T1588, -NHS (O ₂ ) -T1589, -NT1590S (O ₂ ) -T1591, -S-T1592, -S (O) -T1593, -S (O ₂ ) -T1594, -S (O ₂ ) NH-T1595, -S (O ₂ ) NT1596T1597, -S (O ₂ ) O-T1598, -P (O) (OT1599) (OT1600), -Si (T1601) (T1602) (T1603) ";
At that time, T1552, T1553, T1554, T1555, T1556, T1557, T1558, T1559, T1560, T1561, T1562, T1563, T1564, T1565, T1566, T1567, T1568, T1568, T1570, T1571, T1573, T1573, T1574, . , T1601, T1602, and T1603 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1558, T1559 and / or T1657, T1568 and / or T1580, T1581 and / or T1587, T1588 and / or T1596, T1597 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1604, -NT1605T1606, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1607, -C (O) O-T1608, -C (O) NH-T1609, -C (O) NT1610T1611, -O-T1612, -O (-T1613-O) _rx -H (rx = 1, 2, 3, 4, 5), -O (-T1614-O) _rx -T1615 (rx = 1, 2, 3, 4, 5), -OC (O) -T1616, -OC (O) -O-T1617, -OC (O) -NHT1618, -O-C (O)- NT1619T1620, -OP (O) (OT1621) (OT1622), -OSi (T1623) (T1624) (T1625), -OS (O ₂ ) -T1626, -NHC (O) -T1627, -NT1628C (O) -T1629, -NH-C (O) -O-T1630, -NH-C (O) -NH-T1631, -NH-C (O ) -NT1632T1633, -NT1634-C (O) -O-T1635, -NT1636-C (O) -NH-T1637, -NT1638-C (O) -NT1639T1640, -NHS (O ₂ ) -T1641, -NT1642S (O ₂ ) -T1643, -S-T1644, -S (O) -T1645, -S (O ₂ ) -T1646, -S (O ₂ ) NH-T1647, -S (O ₂ ) NT1648T1649, -S (O ₂ ) O-T1650, -P (O) (OT1651) (OT1652), -Si (T1653) (T1654) (T1655) ";
At that time, T1604, T1605, T1606, T1607, T1608, T1609, T1610, T1611, T1612, T1613, T1614, T1615, T1616, T1617, T1618, T1619, T1620, T1621, T1622, T1623, T1624, T1625, T1626, T1627 , T1628, T1629, T1630, T1631, T1632, T1633, T1634, T1635, T1636, T1637, T1638, T1639, T1640, T1641, T1642, T1643, T1644, T1645, T1646, T1647, T1648, T1649, T1650, T1651 , T1653, T1654, T1655 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1610, T1611 and / or T1619, T1620 and / or T1632, T1633 and / or T1639, T1640 and / or T1648, T1649 can each be taken together to form a "heterocyclyl";
In so doing, optionally, T1446, T1447 may be taken together to form "heterocyclyl";
(3) "-C (Y8) NZ43Z44, -C (= NZ45) -Z46, -C (Y9) NZ47-Y10-Z48";
Y8, Y9, Y10 are then selected from the group consisting of “O, S, ═NH, ═NZ49” independently of each other;
In so doing, the radicals Z43, Z44, Z45, Z46, Z47, Z48, Z49 are selected independently of one another from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -alkyl, -C (O) -C ₉ ~ C ₃₀ -Alkyl, -C (O) -cycloalkyl, -C (O) -cycloalkylalkyl, -C (O) -aryl, -C (O) -arylalkyl, -C (O) -heteroaryl, -C (O) -heteroarylalkyl, -C (O) -heterocyclyl, -C (O) -heterocyclylalkyl, -S (O ₂ ) -Alkyl, -S (O ₂ -C ₉ ~ C ₃₀ -Alkyl, -S (O ₂ ) -Cycloalkyl, -S (O ₂ ) -Cycloalkylalkyl, -S (O ₂ ) -Aryl, -S (O ₂ ) -Arylalkyl, -S (O ₂ ) -Heteroaryl, -S (O ₂ ) -Heteroarylalkyl, -S (O ₂ ) -Heterocyclyl, -S (O ₂ ) -Heterocyclylalkyl ";
In that case, depending on the case, the substituents of the substituent group (I) may be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of each other: :
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1656, -NT1657T1658, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1659, -C (O) O-T1660, -C (O) NH-T1661, -C (O) NT1662T1663, -O-T1664, -O (-T1665-O) _ry -H (ry = 1, 2, 3, 4, 5), -O (-T1666-O) _ry -T1667 (ry = 1, 2, 3, 4, 5), -OC (O) -T1668, -OC (O) -O-T1669, -OC (O) -NHT1670, -O-C (O)- NT1671T1672, -OP (O) (OT1673) (OT1674), -OSi (T1675) (T1676) (T1677), -OS (O ₂ ) -T1678, -NHC (O) -T1679, -NT1680C (O) -T1681, -NH-C (O) -O-T1682, -NH-C (O) -NH-T1683, -NH-C (O ) -NT1684T1685, -NT1686-C (O) -O-T1687, -NT1688-C (O) -NH-T1688, -NT1690-C (O) -NT1691T1692, -NHS (O ₂ ) -T1693, -NT1694S (O ₂ ) -T1695, -S-T1696, -S (O) -T1697, -S (O ₂ ) -T1698, -S (O ₂ ) NH-T1699, -S (O ₂ ) NT1700T1701, -S (O ₂ ) O-T1702, -P (O) (OT1703) (OT1704), -Si (T1705) (T1706) (T1707) ";
At that time, T1656, T1657, T1658, T1659, T1660, T1661, T1662, T1663, T1664, T1665, T1666, T1667, T1668, T1669, T1670, T1671, T1672, T1673, T1674, T1675, T1676, T1678, T1678, T1679, T1679 T1680, T1681, T1682, T1683, T1684, T1687, T1686, T1687, T1688, T1690, T1690, T1691, T1692, T1693, T1694, T1695, T1696, T1697, T1698, T1699, T1700, T1701, T1702, T1703 , T1705, T1706, and T1707 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1662, T1663 and / or T1671, T1672 and / or T1684, T1685 and / or T1691, T1692 and / or T1700, T1701 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1708, -NT1709T1710, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1711, -C (O) O-T1712, -C (O) NH-T1713, -C (O) NT1714T1715, -O-T1716, -O (-T1717-O) _rz -H (rz = 1, 2, 3, 4, 5), -O (-T1718-O) _rz -T1719 (rz = 1, 2, 3, 4, 5), -OC (O) -T1720, -OC (O) -O-T1721, -OC (O) -NHT1722, -O-C (O)- NT1723T1724, -OP (O) (OT1725) (OT1726), -OSi (T1727) (T1728) (T1729), -OS (O ₂ ) -T1730, -NHC (O) -T1731, -NT1732C (O) -T1733, -NH-C (O) -O-T1734, -NH-C (O) -NH-T1735, -NH-C (O ) -NT1736T1737, -NT1738-C (O) -O-T1739, -NT1740-C (O) -NH-T1741, -NT1742-C (O) -NT1743T1744, -NHS (O ₂ ) -T1745, -NT1746S (O ₂ ) -T1747, -S-T1748, -S (O) -T1749, -S (O ₂ ) -T1750, -S (O ₂ ) NH-T1751, -S (O ₂ ) NT1752T1753, -S (O ₂ ) O-T1754, -P (O) (OT1755) (OT1756), -Si (T1757) (T1758) (T1759) ";
At that time, T1708, T1709, T1710, T1711, T1712, T1713, T1714, T1715, T1716, T1717, T1718, T1719, T1720, T1721, T1722, T1723, T1724, T1725, T1726, T1727, T1728, T1729, T1730, T1731 , T1732, T1733, T1734, T1735, T1736, T1737, T1738, T1739, T1740, T1741, T1742, T1743, T1744, T1745, T1746, T1747, T1748, T1750, T1750, T1751, T1752, T1753, T1754, T1755 , T1757, T1758, T1759 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally T1714, T1715 and / or T1723, T1724 and / or T1736, T1737 and / or T1743, T1744 and / or T1752, T1753 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHT1760, -NT1761T1762, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -T1763, -C (O) O-T1764, -C (O) NH-T1765, -C (O) NT1766T1767, -O-T1768, -O (-T1769-O) _ra -H (ra = 1, 2, 3, 4, 5), -O (-T1770-O) _ra -T1771 (ra = 1, 2, 3, 4, 5), -OC (O) -T1772, -OC (O) -O-T1773, -OC (O) -NHT1774, -O-C (O)- NT1775T1776, -OP (O) (OT1777) (OT1778), -OSi (T1799) (T1780) (T1781), -OS (O ₂ ) -T1782, -NHC (O) -T1783, -NT1784C (O) -T1785, -NH-C (O) -O-T1786, -NH-C (O) -NH-T1787, -NH-C (O ) -NT1788T1789, -NT1790-C (O) -O-T1791, -NT1792-C (O) -NH-T1793, -NT1794-C (O) -NT1795T1796, -NHS (O ₂ ) -T1797, -NT1798S (O ₂ ) -T1799, -S-T1800, -S (O) -T1801, -S (O ₂ ) -T1802, -S (O ₂ ) NH-T1803, -S (O ₂ ) NT1804T1805, -S (O ₂ ) O-T1806, -P (O) (OT1807) (OT1808), -Si (T1809) (T1810) (T1811) ";
At that time, T1760, T1761, T1762, T1763, T1764, T1765, T1766, T1767, T1768, T1769, T1770, T1771, T1772, T1773, T1774, T1775, T1776, T1777, T1778, T1777, T1781, T1783, T1783, T1783 T1784, T1785, T1786, T1787, T1788, T1789, T1790, T1791, T1792, T1793, T1794, T1795, T1796, T1797, T1798, T1799, T1800, T1801, T1802, T1803, T1804, T1805, T1806, T1807, T1806, T1807 , T1809, T1810, T1811 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally selected from T1766, T1767 and / or T1775, T1776 and / or T1788, T1789 and / or T1795, T1796 and / or T1804, T1805 may each be taken together to form a "heterocyclyl";
as well as
The groups Z3, Z4 are selected from the group consisting of:
(E) hydrogen;
(F) halogen, F, Cl, Br, I;
(G) unsubstituted or substituted alkyl or C ₉ ~ C ₃₀ -Alkyl,
In this case, depending on the case, the alkyl group or C ₉ ~ C ₃₀ The alkyl group may be substituted with at least one substituent selected from the group consisting of:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB457, -NB458B459, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B460, -C (O) O-B461, -C (O) NH-B462, -C (O) NB463B464, -O-B465, -O (-B466-O) _x -H (x = 1, 2, 3, 4, 5), -O (-B467-O) _x -B468 (x = 1, 2, 3, 4, 5), -OC (O) -B469, -OC (O) -O-B470, -OC (O) -NHB471, -O-C (O)- NB472B473, -OP (O) (OB474) (OB475), -OSi (B476) (B477) (B478), -OS (O ₂ ) -B479, -NHC (O) -B480, -NB481C (O) -B482, -NH-C (O) -O-B483, -NH-C (O) -NH-B484, -NH-C (O ) -NB485B486, -NB487-C (O) -O-B488, -NB489-C (O) -NH-B490, -NB491-C (O) -NB492B493, -NHS (O ₂ ) -B494, -NB495S (O ₂ ) -B496, -S-B497, -S (O) -B498, -S (O ₂ ) -B499, -S (O ₂ ) NH-B500, -S (O ₂ ) NB501B502, -S (O ₂ ) O-B503, -P (O) (OB504) (OB505), -Si (B506) (B507) (B508) ";
At that time, B457, B458, B459, B460, B461, B462, B463, B464, B465, B466, B467, B468, B469, B470, B471, B472, B473, B474, B475, B476, B477, B478, B480 B481, B482, B483, B484, B485, B486, B487, B488, B489, B490, B491, B492, B493, B494, B495, B496, B497, B498, B499, B500, B501, B502, B503, B504, B504 , B506, B507, B508 are independently of each other "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B463, B464 and / or B472, B473 and / or B485, B486 and / or B492, B493 and / or B501, B502 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB509, -NB510B511, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B512, -C (O) O-B513, -C (O) NH-B514, -C (O) NB515B516, -O-B517, -O (-B518-O) _y -H (y = 1, 2, 3, 4, 5), -O (-B519-O) _y -B520 (y = 1, 2, 3, 4, 5), -OC (O) -B521, -OC (O) -O-B522, -OC (O) -NHB523, -O-C (O)- NB524B525, -OP (O) (OB526) (OB527), -OSi (B528) (B529) (B530), -OS (O ₂ ) -B531, -NHC (O) -B532, -NB533C (O) -B534, -NH-C (O) -O-B535, -NH-C (O) -NH-B536, -NH-C (O ) -NB537B538, -NB539-C (O) -O-B540, -NB541-C (O) -NH-B542, -NB543-C (O) -NB544B545, -NHS (O ₂ ) -B546, -NB547S (O ₂ ) -B548, -S-B549, -S (O) -B550, -S (O ₂ ) -B551, -S (O ₂ ) NH-B552, -S (O ₂ ) NB553B554, -S (O ₂ ) O-B555, -P (O) (OB556) (OB557), -Si (B558) (B559) (B560) ";
At that time, B509, B510, B511, B512, B513, B514, B515, B516, B517, B518, B519, B520, B521, B522, B523, B524, B525, B526, B527, B528, B529, B530, B531, B532 B533, B534, B535, B536, B537, B538, B539, B540, B541, B542, B543, B544, B545, B546, B547, B548, B549, B550, B551, B552, B553, B554, B555, B556, B555, B556 , B558, B559, B560 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B515, B516 and / or B524, B525 and / or B537, B538 and / or B544, B545 and / or B553, B554 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB561, -NB562B563, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B564, -C (O) O-B565, -C (O) NH-B566, -C (O) NB567B568, -O-B569, -O (-B570-O) _z -H (z = 1, 2, 3, 4, 5), -O (-B571-O) _z -B572 (z = 1, 2, 3, 4, 5), -OC (O) -B573, -OC (O) -O-B574, -OC (O) -NHB575, -O-C (O)- NB576B577, -OP (O) (OB578) (OB579), -OSi (B580) (B581) (B582), -OS (O ₂ ) -B583, -NHC (O) -B584, -NB585C (O) -B586, -NH-C (O) -O-B587, -NH-C (O) -NH-B588, -NH-C (O ) -NB589B590, -NB591-C (O) -O-B592, -NB593-C (O) -NH-B594, -NB595-C (O) -NB596B597, -NHS (O ₂ ) -B598, -NB599S (O ₂ ) -B600, -S-B601, -S (O) -B602, -S (O ₂ ) -B603, -S (O ₂ ) NH-B604, -S (O ₂ ) NB605B606, -S (O ₂ ) O-B607, -P (O) (OB608) (OB609), -Si (B610) (B611) (B612) ";
At that time, B561, B562, B563, B564, B565, B566, B567, B568, B569, B570, B571, B572, B573, B574, B575, B576, B577, B578, B579, B580, B581, B582, B58, B58 , B585, B586, B587, B588, B589, B590, B591, B592, B593, B594, B595, B596, B597, B598, B599, B600, B601, B602, B603, B604, B605, B606, B607, B608, B607 , B610, B611, B612 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B567, B568 and / or B576, B577 and / or B589, B590 and / or B596, B597 and / or B605, B606 may each be taken together to form a "heterocyclyl";
(H) unsubstituted or substituted aryl,
In this case, the aryl group may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB613, -NB614B615, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B616, -C (O) O-B617, -C (O) NH-B618, -C (O) NB619B620, -O-B621, -O (-B622-O) _a -H (a = 1, 2, 3, 4, 5), -O (-B623-O) _a -B624 (a = 1, 2, 3, 4, 5), -OC (O) -B625, -OC (O) -O-B626, -OC (O) -NHB627, -O-C (O)- NB628B629, -OP (O) (OB630) (OB631), -OSi (B632) (B633) (B634), -OS (O ₂ ) -B635, -NHC (O) -B636, -NB637C (O) -B638, -NH-C (O) -O-B639, -NH-C (O) -NH-B640, -NH-C (O ) -NB641B642, -NB643-C (O) -O-B644, -NB645-C (O) -NH-B646, -NB647-C (O) -NB648B649, -NHS (O ₂ ) -B650, -NB651S (O ₂ ) -B652, -S-B653, -S (O) -B654, -S (O ₂ ) -B655, -S (O ₂ ) NH-B656, -S (O ₂ ) NB657B658, -S (O ₂ ) O-B659, -P (O) (OB660) (OB661), -Si (B662) (B663) (B664) ";
At that time, B613, B614, B615, B616, B617, B618, B619, B620, B621, B622, B623, B624, B625, B626, B627, B628, B629, B630, B631, B632, B633, B634, B635, B636 , B637, B638, B639, B640, B641, B642, B643, B644, B645, B646, B647, B648, B649, B650, B651, B652, B653, B654, B655, B656, B657, B658, B659, B660, B659, B660 , B662, B663, B664 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B619, B620 and / or B628, B629 and / or B641, B642 and / or B648, B649 and / or B657, B658 may each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB665, -NB666B667, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B668, -C (O) O-B669, -C (O) NH-B670, -C (O) NB671B672, -O-B673, -O (-B674-O) _b -H (b = 1, 2, 3, 4, 5), -O (-B675-O) _b -B676 (b = 1, 2, 3, 4, 5), -OC (O) -B677, -OC (O) -O-B678, -OC (O) -NHB679, -O-C (O)- NB680B681, -OP (O) (OB682) (OB683), -OSi (B684) (B685) (B686), -OS (O ₂ ) -B687, -NHC (O) -B688, -NB689C (O) -B690, -NH-C (O) -O-B691, -NH-C (O) -NH-B692, -NH-C (O ) -NB693B694, -NB695-C (O) -O-B696, -NB697-C (O) -NH-B698, -NB699-C (O) -NB700B701, -NHS (O ₂ ) -B702, -NB703S (O ₂ ) -B704, -S-B705, -S (O) -B706, -S (O ₂ ) -B707, -S (O ₂ ) NH-B708, -S (O ₂ ) NB709B710, -S (O ₂ ) O-B711, -P (O) (OB712) (OB713), -Si (B714) (B715) (B716) ";
At that time, B665, B666, B667, B668, B669, B670, B671, B672, B673, B674, B675, B676, B677, B678, B679, B680, B681, B682, B683, B684, B685, B686, B687 B689, B690, B691, B692, B693, B694, B695, B696, B697, B698, B699, B700, B701, B702, B703, B704, B705, B706, B707, B708, B709, B710, B711, B712 , B714, B715, B716 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B671, B672 and / or B680, B681 and / or B693, B694 and / or B700, B701 and / or B709, B710 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB717, -NB718B719, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B720, -C (O) O-B721, -C (O) NH-B722, -C (O) NB723B724, -O-B725, -O (-B726-O) _c -H (c = 1, 2, 3, 4, 5), -O (-B727-O) _c -B728 (c = 1, 2, 3, 4, 5), -OC (O) -B729, -OC (O) -O-B730, -OC (O) -NHB731, -O-C (O)- NB732B733, -OP (O) (OB734) (OB735), -OSi (B736) (B737) (B738), -OS (O ₂ ) -B739, -NHC (O) -B740, -NB741C (O) -B742, -NH-C (O) -O-B743, -NH-C (O) -NH-B744, -NH-C (O ) -NB745B746, -NB747-C (O) -O-B748, -NB749-C (O) -NH-B750, -NB751-C (O) -NB752B753, -NHS (O ₂ ) -B754, -NB755S (O ₂ ) -B756, -S-B757, -S (O) -B758, -S (O ₂ ) -B759, -S (O ₂ ) NH-B760, -S (O ₂ ) NB761B762, -S (O ₂ ) O-B763, -P (O) (OB764) (OB765), -Si (B766) (B767) (B768) ";
At that time, B717, B718, B719, B720, B721, B722, B723, B724, B725, B726, B727, B728, B729, B730, B731, B732, B733, B734, B735, B736, B737, B738, B739, B740 , B741, B742, B743, B744, B745, B746, B747, B748, B749, B750, B751, B752, B753, B754, B755, B756, B757, B758, B759, B760, B761, B762, B763, B764 , B766, B767, B768 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B723, B724 and / or B732, B733 and / or B745, B746 and / or B752, B753 and / or B761, B762 may each be taken together to form a "heterocyclyl";
(J) unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may optionally be substituted with at least one substituent selected from the group consisting of the following, which are the same or different:
(I) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB769, -NB770B771, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B772, -C (O) O-B773, -C (O) NH-B774, -C (O) NB775B776, -O-B777, -O (-B778-O). _d -H (d = 1, 2, 3, 4, 5), -O (-B779-O) _d -B780 (d = 1, 2, 3, 4, 5), -OC (O) -B781, -OC (O) -O-B782, -OC (O) -NHB783, -O-C (O)- NB784B785, -OP (O) (OB786) (OB787), -OSi (B788) (B789) (B790), -OS (O ₂ ) -B791, -NHC (O) -B792, -NB793C (O) -B794, -NH-C (O) -O-B795, -NH-C (O) -NH-B796, -NH-C (O ) -NB797B798, -NB799-C (O) -O-B800, -NB801-C (O) -NH-B802, -NB803-C (O) -NB804B805, -NHS (O ₂ ) -B806, -NB807S (O ₂ ) -B808, -S-B809, -S (O) -B810, -S (O ₂ ) -B811, -S (O ₂ ) NH-B812, -S (O ₂ ) NB813B814, -S (O ₂ ) O-B815, -P (O) (OB816) (OB817), -Si (B818) (B819) (B820) ";
At that time, B769, B770, B771, B772, B773, B774, B775, B776, B777, B778, B779, B780, B781, B782, B783, B784, B785, B786, B787, B788, B789, B790, B791, 792 B793, B794, B795, B796, B797, B798, B799, B800, B801, B802, B803, B804, B805, B806, B807, B808, B809, B810, B811, B812, B813, B814, B815, B816, B815, B816 , B818, B819, B820 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B775, B776 and / or B784, B785 and / or B797, B798 and / or B804, B805 and / or B813, B814 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB821, -NB822B823, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B824, -C (O) O-B825, -C (O) NH-B826, -C (O) NB827B828, -O-B829, -O (-B830-O) _e -H (e = 1, 2, 3, 4, 5), -O (-B831-O) _e -B832 (e = 1, 2, 3, 4, 5), -OC (O) -B833, -OC (O) -O-B834, -OC (O) -NHB835, -O-C (O)- NB836B837, -OP (O) (OB838) (OB839), -OSi (B840) (B841) (B842), -OS (O ₂ ) -B843, -NHC (O) -B844, -NB845C (O) -B846, -NH-C (O) -O-B847, -NH-C (O) -NH-B848, -NH-C (O ) -NB849B850, -NB851-C (O) -O-B852, -NB853-C (O) -NH-B854, -NB855-C (O) -NB856B857, -NHS (O ₂ ) -B858, -NB859S (O ₂ ) -B860, -S-B861, -S (O) -B862, -S (O ₂ ) -B863, -S (O ₂ ) NH-B864, -S (O ₂ ) NB865B866, -S (O ₂ ) O-B867, -P (O) (OB868) (OB869), -Si (B870) (B871) (B872) ";
At that time, B821, B822, B823, B824, B825, B826, B827, B828, B829, B830, B831, B832, B833, B834, B835, B836, B837, B838, B839, B840, B841, B842, B844 B845, B846, B847, B848, B849, B850, B851, B852, B853, B854, B855, B856, B857, B858, B859, B860, B861, B862, B863, B864, B865, B866, B867, 86 , B870, B871, B872 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B827, B828 and / or B836, B837 and / or B849, B850 and / or B856, B857 and / or B865, B866 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB873, -NB874B875, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B876, -C (O) O-B877, -C (O) NH-B878, -C (O) NB879B880, -O-B881, -O (-B882-O) _f -H (f = 1, 2, 3, 4, 5), -O (-B883-O) _f -B884 (f = 1, 2, 3, 4, 5), -OC (O) -B885, -OC (O) -O-B886, -OC (O) -NHB887, -O-C (O)- NB888B889, -OP (O) (OB890) (OB891), -OSi (B892) (B893) (B894), -OS (O ₂ ) -B895, -NHC (O) -B896, -NB897C (O) -B898, -NH-C (O) -O-B899, -NH-C (O) -NH-B900, -NH-C (O ) -NB901B902, -NB903-C (O) -O-B904, -NB905-C (O) -NH-B906, -NB907-C (O) -NB908B909, -NHS (O ₂ ) -B910, -NB911S (O ₂ ) -B912, -S-B913, -S (O) -B914, -S (O ₂ ) -B915, -S (O ₂ ) NH-B916, -S (O ₂ ) NB917B918, -S (O ₂ ) O-B919, -P (O) (OB920) (OB921), -Si (B922) (B923) (B924) ";
In that case, B873, B874, B875, B876, B877, B878, B879, B880, B881, B882, B883, B884, B885, B886, B887, B888, B889, B890, B891, B892, B893, B894, B895, B896 , B897, B898, B899, B900, B901, B902, B903, B904, B905, B906, B907, B908, B909, B910, B911, B912, B913, B914, B915, B916, B917, B918, B919, B920 , B922, B923, B924 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B879, B880 and / or B888, B889 and / or B901, B902 and / or B908, B909 and / or B917, B918 may each be taken together to form a "heterocyclyl";
(K) OZ6,
Z6 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB925, -NB926B927, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B928, -C (O) O-B929, -C (O) NH-B930, -C (O) NB931B932, -O-B933, -O (-B934-O) _g -H (g = 1, 2, 3, 4, 5), -O (-B935-O) _g -B936 (g = 1, 2, 3, 4, 5), -OC (O) -B937, -OC (O) -O-B938, -OC (O) -NHB939, -O-C (O)- NB940B941, -OP (O) (OB942) (OB943), -OSi (B944) (B945) (B946), -OS (O ₂ ) -B947, -NHC (O) -B948, -NB949C (O) -B950, -NH-C (O) -O-B951, -NH-C (O) -NH-B952, -NH-C (O ) -NB953B954, -NB955-C (O) -O-B956, -NB957-C (O) -NH-B958, -NB959-C (O) -NB960B961, -NHS (O ₂ ) -B962, -NB963S (O ₂ ) -B964, -S-B965, -S (O) -B966, -S (O ₂ ) -B967, -S (O ₂ ) NH-B968, -S (O ₂ ) NB969B970, -S (O ₂ ) O-B971, -P (O) (OB972) (OB973), -Si (B974) (B975) (B976) ";
In that case, B925, B926, B927, B928, B929, B930, B931, B932, B933, B934, B935, B936, B937, B938, B939, B940, B941, B942, B943, B944, B945, B946, B947, B948 B949, B950, B951, B952, B953, B954, B955, B956, B957, B958, B959, B960, B961, B962, B963, B964, B965, B966, B967, B968, B969, B970, B971, B972 , B974, B975, B976 independently represent "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B931, B932 and / or B940, B941 and / or B953, B954 and / or B960, B961 and / or B969, B970 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB977, -NB978B979, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B980, -C (O) O-B981, -C (O) NH-B982, -C (O) NB983B984, -O-B985, -O (-B986-O) _h -H (h = 1, 2, 3, 4, 5), -O (-B987-O) _h -B988 (h = 1, 2, 3, 4, 5), -OC (O) -B989, -OC (O) -O-B990, -OC (O) -NHB991, -O-C (O)- NB992B993, -OP (O) (OB994) (OB995), -OSi (B996) (B997) (B998), -OS (O ₂ ) -B999, -NHC (O) -B1000, -NB1001C (O) -B1002, -NH-C (O) -O-B1003, -NH-C (O) -NH-B1004, -NH-C (O ) -NB1005B1006, -NB1007-C (O) -O-B1008, -NB1009-C (O) -NH-B1010, -NB1011-C (O) -NB1012B1013, -NHS (O ₂ ) -B1014, -NB1015S (O ₂ ) -B1016, -S-B1017, -S (O) -B1018, -S (O ₂ ) -B1019, -S (O ₂ ) NH-B1020, -S (O ₂ ) NB1021B1022, -S (O ₂ ) O-B1023, -P (O) (OB1024) (OB1025), -Si (B1026) (B1027) (B1028) ";
At that time, B977, B978, B979, B980, B981, B982, B983, B984, B985, B986, B987, B988, B989, B990, B991, B992, B993, B994, B995, B996, B997, B998, B999, B999 , B1001, B1002, B1003, B1004, B1005, B1006, B1007, B1008, B1009, B1010, B1011, B1012, B1013, B1014, B1015, B1016, B1017, B1018, B1019, B1020, B1021, B1022, B1023, B1024 , B1026, B1027, B1028 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B983, B984 and / or B992, B993 and / or B1005, B1006 and / or B1012, B1013 and / or B1021, B1022 may each be taken together to form a "heterocyclyl";
(L) SZ7,
Z7 is then independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl ";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1029, -NB1030B1031, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1032, -C (O) O-B1033, -C (O) NH-B1034, -C (O) NB1035B1036, -O-B1037, -O (-B1038-O) _i -H (i = 1, 2, 3, 4, 5), -O (-B1039-O) _i -B1040 (i = 1, 2, 3, 4, 5), -OC (O) -B1041, -OC (O) -O-B1042, -OC (O) -NHB1043, -O-C (O)- NB1044B1045, -OP (O) (OB1046) (OB1047), -OSi (B1048) (B1049) (B1050), -OS (O ₂ ) -B1051, -NHC (O) -B1052, -NB1053C (O) -B1054, -NH-C (O) -O-B1055, -NH-C (O) -NH-B1056, -NH-C (O ) -NB1057B1058, -NB1059-C (O) -O-B1060, -NB1061-C (O) -NH-B1062, -NB1063-C (O) -NB1064B1065, -NHS (O ₂ ) -B1066, -NB1067S (O ₂ ) -B1068, -S-B1069, -S (O) -B1070, -S (O ₂ ) -B1071, -S (O ₂ ) NH-B1072, -S (O ₂ ) NB1073B1074, -S (O ₂ ) O-B1075, -P (O) (OB1076) (OB1077), -Si (B1078) (B1079) (B1080) ";
At that time, B1029, B1030, B1031, B1032, B1033, B1034, B1035, B1036, B1037, B1038, B1039, B1040, B1041, B1042, B1043, B1044, B1045, B1046, B1047, B1048, B1049, B1050, B1051, B105, , B1053, B1054, B1055, B1056, B1057, B1058, B1059, B1060, B1061, B1062, B1063, B1064, B1065, B1066, B1067, B1068, B1069, B1070, B1071, B1072, B1073, B1074, B1075, B1076 , B1078, B1079, B1080 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1035, B1036 and / or B1044, B1045 and / or B1057, B1058 and / or B1064, B1065 and / or B1073, B1074 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1081, -NB1082B1083, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1084, -C (O) O-B1085, -C (O) NH-B1086, -C (O) NB1087B1088, -O-B1089, -O (-B1090-O) _j -H (j = 1, 2, 3, 4, 5), -O (-B1091-O) _j -B1092 (j = 1, 2, 3, 4, 5), -OC (O) -B1093, -OC (O) -O-B1094, -OC (O) -NHB1095, -O-C (O)- NB1096B1097, -OP (O) (OB1098) (OB1099), -OSi (B1100) (B1101) (B1102), -OS (O ₂ ) -B1103, -NHC (O) -B1104, -NB1105C (O) -B1106, -NH-C (O) -O-B1107, -NH-C (O) -NH-B1108, -NH-C (O ) -NB1109B1110, -NB1111-C (O) -O-B1112, -NB1113-C (O) -NH-B1114, -NB1115-C (O) -NB1116B1117, -NHS (O ₂ ) -B1118, -NB1119S (O ₂ ) -B1120, -S-B1121, -S (O) -B1122, -S (O ₂ ) -B1123, -S (O ₂ ) NH-B1124, -S (O ₂ ) NB1125B1126, -S (O ₂ ) O-B1127, -P (O) (OB1128) (OB1129), -Si (B1130) (B1131) (B1132) ";
At that time, B1081, B1082, B1083, B1084, B1085, B1086, B1087, B1088, B1089, B1090, B1091, B1092, B1093, B1094, B1095, B1096, B1097, B1098, B1099, B1100, B1101, B1102, B1103, B1104 , B1105, B1106, B1107, B1108, B1109, B1110, B1111, B1112, B1113, B1114, B1115, B1116, B1117, B1118, B1119, B1120, B1121, B1122, B1123, B1124, B1125, B1126, B1127, B1128 , B1130, B1131, and B1132, independently of one another, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1087, B1088 and / or B1096, B1097 and / or B1109, B1110 and / or B1116, B1117 and / or B1125, B1126 may each be taken together to form a "heterocyclyl";
(M) NZ8Z9,
Z8 and Z9 are then selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C (O) -B1133, -C (O) O-B1134, -C (O)- NB1135B1136, -S (O ₂ ) -B1137, -S (O ₂ ) O-B1138 ";
In this case, B1133, B1134, B1135, B1136, B1137, B1138 are independent of each other as “hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and, optionally, B1135, B1136 together are" Heterocyclyl "can also be formed;
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1139, -NB1140B1141, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1142, -C (O) O-B1143, -C (O) NH-B1144, -C (O) NB1145B1146, -O-B1147, -O (-B1148-O). _k -H (k = 1, 2, 3, 4, 5), -O (-B1149-O) _k -B1150 (k = 1, 2, 3, 4, 5), -OC (O) -B1151, -OC (O) -O-B1152, -OC (O) -NHB1153, -O-C (O)- NB1154B1155, -OP (O) (OB1156) (OB1157), -OSi (B1158) (B1159) (B1160), -OS (O ₂ ) -B1161, -NHC (O) -B1162, -NB1163C (O) -B1164, -NH-C (O) -O-B1165, -NH-C (O) -NH-B1166, -NH-C (O ) -NB1167B1168, -NB1169-C (O) -O-B1170, -NB1171-C (O) -NH-B1172, -NB1173-C (O) -NB1174B1175, -NHS (O ₂ ) -B1176, -NB1177S (O ₂ ) -B1178, -S-B1179, -S (O) -B1180, -S (O ₂ ) -B1181, -S (O ₂ ) NH-B1182, -S (O ₂ ) NB1183B1184, -S (O ₂ ) O-B1185, -P (O) (OB1186) (OB1187), -Si (B1188) (B1189) (B1190) ";
At that time, B1139, B1140, B1141, B1142, B1143, B1144, B1145, B1146, B1147, B1148, B1149, B1150, B1151, B1152, B1153, B1154, B1155, B1156, B1157, B1158, B1159, B1160, B1161, B1162 , B1163, B1164, B1165, B1166, B1167, B1168, B1169, B1170, B1171, B1172, B1173, B1174, B1175, B1176, B1177, B1178, B1179, B1180, B1181, B1182, B1183, B1186, B1185, B1186, B1185, B1186 , B1188, B1189, B1190 are independently of each other “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1145, B1146 and / or B1154, B1155 and / or B1167, B1168 and / or B1174, B1175 and / or B1183, B1184 can also be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHB1191, -NB1192B1193, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -B1194, -C (O) O-B1195, -C (O) NH-B1196, -C (O) NB1197B1198, -O-B1199, -O (-B1200-O). _l -H (l = 1, 2, 3, 4, 5), -O (-B1201-O) _l -B1202 (l = 1, 2, 3, 4, 5), -OC (O) -B1203, -OC (O) -O-B1204, -OC (O) -NHB1205, -O-C (O)- NB1206B1207, -OP (O) (OB1208) (OB1209), -OSi (B1210) (B1211) (B1212), -OS (O ₂ ) -B1213, -NHC (O) -B1214, -NB1215C (O) -B1216, -NH-C (O) -O-B1217, -NH-C (O) -NH-B1218, -NH-C (O ) -NB1219B1220, -NB1221-C (O) -O-B1222, -NB1223-C (O) -NH-B1224, -NB1225-C (O) -NB1226B1227, -NHS (O ₂ ) -B1228, -NB1229S (O ₂ ) -B1230, -S-B1231, -S (O) -B1232, -S (O ₂ ) -B1233, -S (O ₂ ) NH-B1234, -S (O ₂ ) NB1235B1236, -S (O ₂ ) O-B1237, -P (O) (OB1238) (OB1239), -Si (B1240) (B1241) (B1242) ";
At that time, B1191, B1192, B1193, B1194, B1195, B1196, B1197, B1198, B1199, B1200, B1201, B1202, B1203, B1204, B1205, B1206, B1207, B1208, B1209, B1210, B1211, B1212, B1213, B12 , B1215, B1216, B1217, B1218, B1219, B1220, B1221, B1222, B1223, B1224, B1225, B1226, B1227, B1228, B1229, B1230, B1231, B1232, B1233, B1234, B1235, B1236, B1237, B1238 , B1240, B1241, B1242 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally B1197, B1198 and / or B1206, B1207 and / or B1219, B1220 and / or B1226, B1227 and / or B1235, B1236 may each be taken together to form a "heterocyclyl";
as well as
The group Z5 is independently selected from the group consisting of:
(I) "hydrogen, alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHD1, -ND2D3, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -D4, -C (O) O-D5, -C (O) NH-D6, -C (O) ND7D8, -O-D9, -O (-D10-O) _r -H (r = 1, 2, 3, 4, 5), -O (-D11-O) _r -D12 (r = 1, 2, 3, 4, 5), -OC (O) -D13, -OC (O) -OD14, -OC (O) -NHD15, -O-C (O)- ND16D17, -OP (O) (OD18) (OD19), -OSi (D20) (D21) (D22), -OS (O ₂ ) -D23, -NHC (O) -D24, -ND25C (O) -D26, -NH-C (O) -O-D27, -NH-C (O) -NH-D28, -NH-C (O ) -ND29D30, -ND31-C (O) -O-D32, -ND33-C (O) -NH-D34, -ND35-C (O) -ND36D37, -NHS (O ₂ ) -D38, -ND39S (O ₂ ) -D40, -S-D41, -S (O) -D42, -S (O ₂ ) -D43, -S (O ₂ ) NH-D44, -S (O ₂ ) ND45D46, -S (O ₂ ) O-D47, -P (O) (OD48) (OD49), -Si (D50) (D51) (D52) ";
At that time, D1, D2, D3, D4, D5, D6, D7, D8, D9, D10, D11, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24 D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, D44, D45, D46, D47, D48, D49 , D50, D51, D52 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally D7, D8 and / or D16, D17 and / or D29, D30 and / or D36, D37 and / or D45, D46 may each be taken together to form a "heterocyclyl";
In this case, the substituents of the substituent group (i) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Ii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHD53, -ND54D55, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -D56, -C (O) O-D57, -C (O) NH-D58, -C (O) ND59D60, -O-D61, -O (-D62-O) _t -H (t = 1, 2, 3, 4, 5), -O (-D63-O) _t -D64 (t = 1, 2, 3, 4, 5), -OC (O) -D65, -OC (O) -O-D66, -OC (O) -NHD67, -O-C (O)- ND68D69, -OP (O) (OD70) (OD71), -OSi (D72) (D73) (D74), -OS (O ₂ ) -D75, -NHC (O) -D76, -ND77C (O) -D78, -NH-C (O) -O-D79, -NH-C (O) -NH-D80, -NH-C (O ) -ND81D82, -ND83-C (O) -O-D84, -ND85-C (O) -NH-D86, -ND87-C (O) -ND88D89, -NHS (O ₂ ) -D90, -ND91S (O ₂ ) -D92, -S-D93, -S (O) -D94, -S (O ₂ ) -D95, -S (O ₂ ) NH-D96, -S (O ₂ ) ND97D98, -S (O ₂ ) O-D99, -P (O) (OD100) (OD101), -Si (D102) (D103) (D104) ";
At that time, D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, D75, D76 D77, D78, D79, D80, D81, D82, D83, D84, D85, D86, D87, D88, D89, D90, D91, D92, D93, D94, D95, D96, D97, D98, D99, D100, D101 , D102, D103, D104 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally D59, D60 and / or D68, D69 and / or D81, D82 and / or D88, D89 and / or D97, D98 can each be taken together to form a “heterocyclyl”;
In this case, the substituents of the substituent group (ii) may optionally be further substituted with at least one substituent selected from the group consisting of the following, the same or different, independently of one another:
(Iii) "alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF _Three , N _Three , NH ₂ , -NHD105, -ND106D107, -NO ₂ , -OH, -OCF _Three , -SH, -O-SO _Three H, -OP (O) (OH) ₂ , -CHO, -COOH, -C (O) NH ₂ , -SO _Three H, -P (O) (OH) ₂ , -C (O) -D108, -C (O) O-D109, -C (O) NH-D110, -C (O) ND111D112, -O-D113, -O (-D114-O) _t -H (t = 1, 2, 3, 4, 5), -O (-D115-O) _t -D116 (t = 1, 2, 3, 4, 5), -OC (O) -D117, -OC (O) -O-D118, -OC (O) -NHD119, -O-C (O)- ND120D121, -OP (O) (OD122) (OD123), -OSi (D124) (D125) (D126), -OS (O ₂ ) -D127, -NHC (O) -D128, -ND129C (O) -D130, -NH-C (O) -O-D131, -NH-C (O) -NH-D132, -NH-C (O ) -ND133D134, -ND135-C (O) -O-D136, -ND137-C (O) -NH-D138, -ND139-C (O) -ND140D141, -NHS (O ₂ ) -D142, -ND143S (O ₂ ) -D144, -S-D145, -S (O) -D146, -S (O ₂ ) -D147, -S (O ₂ ) NH-D148, -S (O ₂ ) ND149D150, -S (O ₂ ) O-D151, -P (O) (OD152) (OD153), -Si (D154) (D155) (D156) ";
At that time, D105, D106, D107, D108, D109, D110, D111, D112, D113, D114, D115, D116, D117, D118, D119, D120, D121, D122, D123, D124, D125, D126, D127, D128 , D129, D130, D131, D132, D133, D134, D135, D136, D137, D138, D139, D140, D141, D142, D143, D144, D145, D146, D147, D148, D149, D150, D151, D152, D153 , D154, D155, D156 are independent of each other, “alkyl, C ₉ ~ C ₃₀ -Alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl "and optionally D111, D112 and / or D120, D121 and / or D133, D134 and / or D140, D141 and / or D149 and D150 can be combined together to form “heterocyclyl”]. A novel pyrido [2,3-b] pyrazine derivative represented by A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 according to (A),
The group Z1 is independently “NZ14Z15”, where Z14 is hydrogen or “aryl” and Z15 is “—C (O) NH-alkyl”; (O) NH-alkyl "may additionally be optionally substituted by" -OH ";
The group Z2 is independently hydrogen;
The group Z3 is independently “substituted aryl”, wherein the “substituted aryl” is substituted by at least one substituent selected from the group consisting of the following, which are the same or different: ing:
(A) "alkyl, -OC (O) -alkyl, -O-alkyl, -NHC (O) -alkyl";
However, said substituents of the substituent group (a) are further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other:
(I) "aryl, heterocyclyl, -O-alkyl-O-alkyl, -O-arylalkyl";
Or
The group Z3 is independently “substituted aryl”, wherein the “substituted aryl” is substituted by at least one substituent selected from the group consisting of the following, which are the same or different: ing:
(B) "-OC (O) -O-alkyl, -OC (O) -O-aryl, -OC (O) -N (alkyl) ₂ , -OC (O) -NH-alkyl, -OC (O ) -C ₉ -C ₃₀ - alkyl, -NHC (O) -O- alkyl, -NHC (O) -NH- alkyl, -NHC (O) -N (alkyl) _2, -Si (alkyl) ₃ ";
In this case, the said substituents of the substituent group (c) may optionally be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "-O-alkyl, -O-arylalkyl";
In that case, the group Z3 may optionally be further substituted with at least one substituent, independently of one another, selected from the group consisting of:
(I) "halogen, F, Cl, Br, I, -O-alkyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 or 2, according to (A),
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl, —NHC (O) NH-butyl-OH”;
The group Z2 is independently hydrogen;
The radicals Z3 are independent of each other, “carbonic acid-4-phenyl-ester-methyl-ester, carbonic acid-3-phenyl-ester-2-methoxy-ethyl-ester, carbonic acid-4-phenyl-ester-2-methoxy-ethyl. -Ester, carbonic acid-4-phenyl-ester-phenyl-ester, N-diethyl-carbamic acid-4-phenyl-ester, 3-phenyl-acrylic acid-4-phenyl-ester, nonadecanoic acid-4-phenyl-ester, Carbonic acid-4-phenyl-ester-isobutyl-ester, carbonic acid-4-phenyl-ester-but-2-ynyl-ester, N-dimethyl-carbamic acid-4-phenyl-ester, N-ethyl-carbamic acid-4- Phenyl-ester, N- (4-phenyl) -carbamic acid-t-butyl-ester, N- (4 -Phenyl) -carbamic acid-2-methoxy-ethyl-ester, 4- (3-ethyl-urea) phenyl, 4- (3,3-methyl-urea) phenyl, 4-morpholin-4-ylmethyl-phenyl, 4 -[2- (2-methoxy-ethoxy) -ethoxy] -phenyl, N- (4-phenyl) -2- (2-methoxy-ethoxy) -acetamide, carbonic acid-4- (2-methoxy) phenyl-ester 2-methoxy-ethyl-ester, carbonic acid-4-phenyl-ester-2-benzyloxy-ethyl-ester, carbonic acid-4- (2-methoxy) phenyl-ester-2-benzyloxy-ethyl-ester, N- ( 4-phenyl) -2-benzyloxy-acetamide, 3-trimethylsilanyl-phenyl, N-diethyl-carbamic acid-4- (2-methoxy) ) Phenyl-ester, N-diethyl-carbamic acid-4- (2-chloro-6-methoxy) -phenyl-ester, carbonic acid-4- (2-methoxy) -phenyl-ester-2- [2- (2- Selected from the group consisting of "methoxy-ethoxy) -ethoxy] -ethyl-esters";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 according to (B),
The group Z1 is independently “NZ14Z15”, wherein Z14 is hydrogen and Z15 is “—C (O) NH-alkyl”;
The group Z2 is independently hydrogen;
The group Z3 is, independently, “substituted heteroaryl”, wherein “substituted heteroaryl” is the same or different by at least one substituent selected from the group consisting of: Has been replaced:
(A) "-NHC (O) -NH-alkyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 or 4, according to (B),
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl”;
The group Z2 is independently hydrogen;
The group Z3, independently of one another, is selected from the group consisting of “6- (3-ethyl-urea) -pyridin-3-yl”;
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1, according to (C),
The group Z1 is independently “NZ14Z15”, wherein Z14 is hydrogen and Z15 is “—C (O) NH-alkyl”;
The group Z2 is independently hydrogen;
The group Z3 is independently “substituted alkyl”, wherein “substituted alkyl” is substituted by at least one substituent selected from the group consisting of the same or different, consisting of: ing:
(A) "aryl, heteroaryl, cycloalkyl, -N (alkyl) ₂ , -O-alkyl";
In this case, the said substituents of the substituent group (a) may optionally be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "halogen, F, Cl, Br, I";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 or 6, according to (C),
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl”;
The group Z2 is independently hydrogen;
The group Z3 is, independently of one another, “phenyl-ethynyl, thiophen-3-yl-ethynyl, cyclopropyl-ethynyl, N-dimethyl-amino-prop-1-ynyl, 2-cyclohexyl-vinyl, 3-methoxy-propenyl, Selected from the group consisting of benzyl, 2- (4-fluoro-phenyl) -ethyl, 2- (4-fluoro-phenyl) -vinyl ”;
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1, according to (D),
The group Z1 is independently “NZ14Z15”, wherein Z14 is hydrogen and Z15 is “—C (O) NH-alkyl”;
The group Z2 is independently hydrogen;
The group Z3 is independently selected from the group consisting of:
(1) "-NZ10Z11";
In so doing, the radicals Z10, Z11, independently of one another, are selected from the group consisting of:
(A) "hydrogen, aryl";
However, when the substituent in the substituent group (a) is not hydrogen, it is further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, regardless of each other: :
(I) "cycloalkyl, heteroaryl, heterocyclylalkyl, -S (O) ₂ -alkyl, -NH-S (O) ₂ -alkyl, -C (O) NH-alkyl, -NH-C (O)- Alkyl, -C (O) O-alkyl ";
(B) "-C (O) -aryl";
In that case, depending on the case, at least one substituent selected from the group consisting of the following, which is the same or different, is independent of each other, and the substituents of the substituent group (a) and / or the substituent group (b) It may be further substituted by a group:
(I) "alkyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 or 8, according to (D),
The group Z1 is independently selected from the group consisting of “—NHC (O) NH-ethyl”;
The group Z2 is independently hydrogen;
The group Z3 is, independently of one another, “4-methyl-benzamide, 4-cyclohexyl-phenyl-amino, 4-methanesulfonyl-phenyl-amino, 3- (N-methanesulfonamido) -4-methyl-phenyl-amino, 3-N-methyl-benzamido-amino, 4-piperidin-1-ylmethyl-phenyl-amino, 4-thiophen-3-ylphenyl-amino, 4-N-acetamido-phenyl-amino, 3-benzoic acid-ethyl- Selected from the group consisting of "ester-amino";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1, according to (E),
The group Z1 is independently selected from the group consisting of:
(A) "NZ24Z25", wherein Z24 is hydrogen and Z25 is "-C (O) -C (O) -O-alkyl" or "-C (O) -C (O)-" NH-alkyl "or" -C (O) -NH-O-alkyl ";
In that case, the said substituents of the substituent group (a) may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "-OSi (alkyl) ₃ , -OC (O) -NH-alkyl, -OC (O) -O-alkyl, -P (O) (O-alkyl) ₂ , -P (O) (OH ) ₂ , -O-alkyl ";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Ii) "heterocyclyl, OH, -N (alkyl) ₂ , -OC (O) -alkyl";
In that case, depending on the case, the above substituents of the substituent group (ii) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Iii) "alkyl";
(B) "NZ26Z27", wherein Z26 is hydrogen and Z27 is "-C (O) -NH-alkyl";
However, said substituents of the substituent group (b) are further substituted by at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other:
(I) "-OSi (alkyl) ₃ , -OC (O) -NH-alkyl, -OC (O) -O-alkyl, -P (O) (O-alkyl) ₂ , -P (O) (OH ) ₂ , -O-alkyl ";
In that case, depending on the case, the substituents of the substituent group (i) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Ii) "heterocyclyl, OH, -N (alkyl) ₂ , -OC (O) -alkyl";
In that case, depending on the case, the above substituents of the substituent group (ii) may be further substituted with at least one substituent selected from the group consisting of the following, which are the same or different, independently of each other. :
(Iii) "alkyl";
The group Z2 is independently hydrogen;
The group Z3 is independently selected from the group consisting of:
(A) "Aryl";
In that case, the said substituents of the substituent group (a) may optionally be substituted by at least one substituent selected from the group consisting of the following, which are the same or different, independently of one another:
(I) "-O-alkyl, OH";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (I) according to claim 1 or 10, according to (E),
The group Z1 is independently of each other “3-methoxy-1-yl-urea, 3- (prop-1-in-3-yl) -1-yl-urea, 3- [4- (t-butyl-dimethyl). -Silanyloxy) -butyl] -1-yl-urea, 4- (carbamic acid-N-ethyl-ester) -butyl-1-yl-urea, 4- (carbonic acid-methyl-ester) -butyl-1-yl- Urea, 4- (carbonic acid-2,3-dihydroxy-propyl-ester) -butyl-1-yl-urea, 4- (carbonic acid-2,2-dimethyl- [1,3] dioxolan-4-ylmethyl-ester) -Butyl-1-yl-urea, 4- (phosphate-diethyl-ester) -butyl-1-yl-urea, 4-phosphate-butyl-1-yl-urea, N-oxalic acid-monoamido-ethyl- Ester, N-ethyl-N'-oxalic acid-a , 2- (phosphate-diethyl-ester) -ethyl-1-yl-urea, 2-phosphate-ethyl-1-yl-urea, 3- (2-diethylamino-ethoxy) -propyl-1-yl- Urea, 4- [2,2-dimethyl-propanoic acid- (2,2-dimethyl-propionyloxy-methoxy) -phosphinoyloxymethyl-ester] -butyl-1-yl-urea, 4- [acetic acid-1 -(1-acetoxy-ethoxy) -ethoxy-phosphinoyloxy] -butyl-1-yl-urea ";
The group Z2 is independently hydrogen;
The group Z3 is independently selected from the group consisting of "phenyl, 4-hydroxy-3-methoxy-phenyl";
The group Z4 is independently hydrogen;
The group Z5 is independently hydrogen;
A pyrido [2,3-b] pyrazine derivative characterized by the above. Formula (II)

[Wherein the substituents R1 to R4 have the following meanings:
R1 and R2, independently of one another, denote hydrogen or NR5R6, provided that when R1 is NR5R6, R2 is H and when R2 is NR5R6, R1 is H;
Wherein R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, the alkyl substituent as defined above, A cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent or alkyl-heteroaryl substituent is again on that side, F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF ₃ , O (-alkyl-O ) _p - alkyl, O- aryl, OSO ₃ H, OP ( _{) (OH) 2, OP (} O) (O _{-alkyl) 2, OP (O) (} O _{aryl) 2, CHO, C (O} ) OH, C (O) OR12, C (O) NH 2, C (O ) NHR12, C (O) NR12R13 , SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (O -alkyl) _2, P (O) (O aryl) _2, Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, which may be the same or different, mono- or poly-substituted, and p may have a value of 0, 1, 2, 3, 4 or 5; And the radicals R12 and R13, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl- It may be heteroaryl, or R12 and R13, taken together, may form a heterocyclyl ring;
And R6 may mean -C (Y) NR7R8, where Y may be O or S independently of each other, and R7 and R8 have the following meanings independently of each other: May be:
hydrogen,
Unsubstituted or substituted alkyl,
In this case, the alkyl group may be F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl- Cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O) -alkyl-heteroaryl, NHSO ₂ -alkyl, NHSO ₂ -cycloalkyl, NHSO ₂ -heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl Aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- cycloalkyl, S- heterocyclyl, S- aryl, S- _{heteroaryl, OH, OCF 3, O (} - alkyl -O) _p -Alkyl, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O ) -Alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl- heteroaryl, OSO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - Heteroshiku Le, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, C (O) - alkyl, C (O) - aryl , C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C (O) NH- cycloalkyl, C (O) NH -Heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-al Kill-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N _{(aryl) 2, C (O) N} ( heteroaryl) _2, SO- alkyl, SO- aryl, SO ₂ - alkyl, SO ₂ - _{aryl, SO 2 NH 2, SO 2} NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl, SO ₂ O-alkyl - aryl, cycloalkyl, heterocyclyl, aryl or heteroaryl And may be the same or different and may be mono- or poly-substituted, where p can take the values 0, 1, 2, 3, 4 or 5.
Unsubstituted or substituted cycloalkyl,
At that time, the cycloalkyl group, F, Cl, Br, I , NH 2, NH- alkyl, NH- cycloalkyl, NH- heterocyclyl, NH- aryl, NH- heteroaryl, NH- alkyl - aryl, NH- Alkyl-heteroaryl, N (alkyl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC ( O) - alkyl - aryl, NHC (O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl , NHSO ₂ - alkyl - heteroaryl, OH, O (- alkyl - ) _P - alkyl, O- cycloalkyl, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - aryl, O- alkyl - heteroaryl, OC (O) - alkyl, OC (O) - cycloalkyl , OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, OSO ₃ H, OSO ₂ -alkyl , OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, CO 2 H , CO ₂ - alkyl, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - f Roariru, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C ( O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl -Heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (Aryl) ₂ , C (O) N (heteroaryl) ₂ , alkyl or aryl, which may be the same or different and mono- or poly-substituted, where p is , 0, 1, 2, 3, 4 or 5;
Unsubstituted or substituted heterocyclyl,
In this case, the heterocyclyl group is OH, O-alkyl, O-aryl, NH ₂ , NH-alkyl, NH-aryl, alkyl, alkyl-aryl or aryl, which are the same or different and mono- or poly-substituted. May be;
Unsubstituted or substituted aryl,
In this case, the aryl group includes F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH- alkyl - cycloalkyl, NH- alkyl - heterocyclyl, NH- alkyl - aryl, NH- alkyl - heteroaryl, NH- alkyl -NH _2, NH- alkyl -OH, N (alkyl) _2, NHC (O) - Alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC ( O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heteroaryl Krill, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- cycloalkyl, S- heterocyclyl, S- aryl, S- heteroaryl, OH, OCF _3, O (- alkyl -O) _p - alkyl, O-R38, O- cycloalkyl, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - cycloalkyl, O- alkyl - heterocyclyl, O- alkyl - aryl, O- alkyl - heteroaryl, O- alkyl _{-OH, O (CH 2) n} -O, OC (O) - alkyl, OC (O) -R38, OC ( O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroary , OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OSO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl , OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, C (O) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ H , CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C ( O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl , C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO-alkyl, SO-aryl, SO ₂ -alkyl, SO ₂ -aryl, SO ₂ NH ₂ , SO ₂ NH - alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl, SO ₂ O-alkyl - aryl Alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted, where p takes the value 0, 1, 2, 3, 4 or 5. And n can be 1, 2 or 3;
Unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may be F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl. , NH- alkyl - cycloalkyl, NH- alkyl - heterocyclyl, NH- alkyl - aryl, NH- alkyl - heteroaryl, NH- alkyl -NH _2, NH- alkyl -OH, N (alkyl) _2, NHC (O) -Alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - Heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- aryl, S- heteroaryl, OH, OCF ₃ , O (-alkyl-O) _p -alkyl, O-R38, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl -Aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -Heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, SO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) _{(OH) 2, C (O} ) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl , C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) _{) 2, SO 2 NH 2,} SO 2 NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl , SO ₂ O-alkyl - aryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, same or different, it may be mono- or polysubstituted, in which p may take the values of 0, 1, 2 or 5;
-C (O) -R39,
Wherein R39 may be alkyl, aryl or heteroaryl, and said alkyl, aryl and heteroaryl substituents may be substituted again on that side;
Or R7 and R8 can be taken together to form a heterocyclyl ring,
R3 and R4 may have the following meanings independently of each other:
hydrogen,
Where R3 and R4 are not simultaneously hydrogen,
Substituted alkyl,
In this case, the alkyl group includes F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , SH, S-alkyl, OH, OCF ₃ , O (- alkyl -O) _p - alkyl, O- _{aryl, OSO 3 H, OP (O} ) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C ( O) OH, C (O) OR14, C (O) NH 2, C (O) NHR14, C (O) NR14R15, SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (Oalkyl) ₂ , P (O) (Oaryl) ₂ , cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different and mono- or polysubstituted, where p Is 0, 1, 2, 3, 4 or 5 And the groups R14 and R15, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, Well, or R14 and R15 can be taken together to form a heterocyclyl ring;
Substituted aryl,
In this case, the aryl groups are the same or different and are NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH- Alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O)- Aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O) -alkyl-heteroaryl, NHSO ₂ -alkyl, NHSO ₂ -cycloalkyl, NHSO ₂ -heterocyclyl, NHSO ₂ -aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - Reel, NHSO ₂ - alkyl - heteroaryl, S- alkyl, S- aryl, S- heteroaryl, O- alkyl, O- cycloalkyl, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - cyclo Alkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) - heteroaryl, OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - f Roariru, C (O) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ - alkyl, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl , CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - heteroaryl, C (O) NH- alkyl, C (O) NH- cycloalkyl, C ( O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH- Alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N _{(aryl) 2, C (O) N} ( heteroaryl) _2, SO- alkyl, SO- aryl, SO ₂ - alkyl, SO ₂ - aryl, SO ₂ NH- alkyl, SO ₂ NH- aryl From the group of: SO ₂ NH-heteroaryl, SO ₂ NH-alkyl-aryl, SO ₂ O-alkyl, SO ₂ O-aryl, SO ₂ O-alkyl-aryl, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl The selected substituent may be mono- or poly-substituted, and the alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl Substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents are Again, O (- alkyl -O) _p - alkyl, OP (O) _{(O-alkyl) 2, OP (O) (} O _{aryl) 2, C (O) OR16} , C (O) NH 2, C (O) NHR16, C (O) NHR16R17, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (O -alkyl) _2, P (O) (O aryl) _2, cycloalkyl, heterocyclyl, Substituted with aryl, heteroaryl or alkylaryl, wherein p can take the values 1, 2, 3, 4 or 5 and the groups R16 and R17 independently of one another are alkyl, cyclo May be alkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl; R16 and R17, taken together, may form a heterocyclyl ring;
Provided that when R3 or R4 means alkyl-heterocyclyl substituted aryl, then R4 or R3 ≠ aryl;
In this case, the aryl groups are the same or different, and are NR20-alkyl, NH-R38, NHC (O) -R38, NR19C (O) -alkyl, NR19C (O) -cycloalkyl, NR19C (O) -heterocyclyl, NR19C (O) -aryl, NR19C (O) -heteroaryl, NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NR19C (O) -alkyl-aryl, NR19C (O) -alkyl- Heteroaryl, NR18C (O) O-R19, NR18C (O) NR18R18, O-R38, OC (O) -R38, OC (O) -alkyl-cycloalkyl, OC (O) -alkyl-heterocyclyl, OC (O ) O-R19, OC (O) NR18R18, OP (O) (O al _{Le) 2, OP (O) (} O _{aryl) 2, C (O) O} -R38, C (O) NH-R38, C (O) NR20- alkyl, C (O) NR19- alkyl -R21, C ( O) NR18O-R18, C (O) NR18NR18R18 may be mono- or poly-substituted with a substituent selected from the group, and the above alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, Heteroaryl substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents again on that side are F, Cl, Br, I, CN, CF ₃ , NH _2, NH- alkyl, NH- aryl, N _{(alkyl) 2, NO 2, SH,} S- _{alkyl, OH, OCF 3, O (} - alkyl -O _p - alkyl, O- _{aryl, OSO 3 H, OP (O} ) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O _{aryl) 2, CHO, C (O} ) OH, C (O) OR22, C (O ) NH 2, C (O) NHR22, C (O) NR22R23, SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) ( O alkyl) ₂ , P (O) (Oaryl) ₂ , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p is 0, 1, 2, 3, 4 and 5 can be taken and the radicals R22 and R23, independently of one another, can be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl. , Alkyl - aryl or alkyl - may be a heteroaryl, or R22 and R23 taken together may form a heterocyclyl ring;
Substituted heteroaryl,
In this case, the heteroaryl group may be the same or different, and may be NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH -Alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NHC (O) -alkyl, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) - aryl, NHC (O) - heteroaryl, NHC (O) - alkyl - aryl, NHC (O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heterocyclyl, NHSO ₂ - aryl , NHSO ₂ - heteroaryl, NHSO ₂ - Al Le - aryl, NHSO ₂ - alkyl - heteroaryl, S- alkyl, S- aryl, S- heteroaryl, O- alkyl, O- cycloalkyl, O- aryl, O- heteroaryl, O- alkyl - cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC ( O) - heteroaryl, OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - hetero aryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, (O) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ - alkyl, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - heteroaryl, C (O) NH- alkyl, C (O) NH- cycloalkyl, C (O) NH -Heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl , C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (a _{Reel) 2, C (O) N} ( heteroaryl) _2, SO ₂ NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₂ O-alkyl, SO ₂ The substituent may be mono- or polysubstituted with a substituent selected from the group of O-aryl, SO ₂ O-alkyl-aryl, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, and the alkyl substituent, cycloalkyl Substituents, heterocyclyl substituents, aryl substituents, heteroaryl substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents are again O ( - alkyl -O) _p - alkyl, OP (O) (O-alkyl) _2, OP (O) ( _{Aryl) 2, C (O) OR16} , C (O) NH 2, C (O) NHR16, C (O) NHR16R17, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) Substituted with (Oalkyl) ₂ , P (O) (Oaryl) ₂ , cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p is 1, 2, 3, 4 or 5 And the groups R16 and R17, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, Well, or R16 and R17 can be taken together to form a heterocyclyl ring;
In this case, the aryl groups are the same or different and are NR20-alkyl, NH-R38, NHC (O) -R38, NR19C (O) -alkyl, NR19C (O) -cycloalkyl, NR19C (O) -heterocyclyl, NR19C (O) -aryl, NR19C (O) -heteroaryl, NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NR19C (O) -alkyl-aryl, NR19C (O) -alkyl- heteroaryl, NR18C (O) O-R19 , NR18C (O) NR18R18, NHSO 2 - alkyl - heterocyclyl, O-R38, O- heterocyclyl, OC (O) -R38, OC (O) - alkyl - cycloalkyl, OC (O) -alkyl-heterocyclyl, OC (O O-R19, OC (O) NR18R18, OP (O) (O _{-alkyl) 2, OP (O) (} O _{aryl) 2, C (O) O} -R38, C (O) NH-R38, C (O) NR20-alkyl, C (O) NR19-alkyl-R21, C (O) NR18O-R18, C (O) NR18NR18R18 may be mono- or polysubstituted and may be substituted Substituents, cycloalkyl substituents, heterocyclyl substituents, aryl substituents, heteroaryl substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents on the side Again, F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF ₃ , O (-alkyl-O) _p -alkyl, O-aryl, OSO ₃ H, OP (O) (OH) ₂ , OP (O) (Oalkyl) ₂ , OP (O) (O _{aryl) 2, CHO, C (O} ) OH, C (O) OR22, C (O) NH 2, C (O) NHR22, C (O) NR22R23, SO 3 H, SO 2 alkyl , SO ₂ aryl, P (O) (OH) ₂ , P (O) (Oalkyl) ₂ , P (O) (Oaryl) ₂ , substituted with alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl Wherein p can have a value of 0, 1, 2, 3, 4 or 5 and the groups R22 and R23, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, Hetero Reel, alkyl - cycloalkyl, alkyl - heterocyclyl, alkyl - aryl or alkyl - may be a heteroaryl, or R22 and R23 taken together may form a heterocyclyl ring;
NR24R25,
In that case, R24 can, -C (O) -R26, -SO 2 R26, -C (O) OR26 or -C (O) may be -NR27R28, and R25 is hydrogen, alkyl, cycloalkyl, aryl Or R 26 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, and R 27 and R 28. Can be independently of each other hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, or R27 and R28 together Become Rosycyl ring can be formed and the alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substitution A group or an alkyl-heteroaryl substituent may be substituted again on that side;
R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl.
R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl,
R38 may be alkyl, wherein the alkyl group may be saturated or unsaturated, linear or branched, has ₉ to 30 carbon atoms, and is C 9- C ₃₀ -alkenyl has at least one C—C double bond, and C ₉ -C ₃₀ -alkynyl has at least one C—C triple bond, wherein said alkenyl is Physiologically tolerated novel pyrido [2,3-b] pyrazine derivatives represented by (E) may be present in configuration or may be present in (Z) configuration as well as compounds of formula I Salts, derivatives or analogs thereof, and solvates, hydrates, polymorphs and prodrugs thereof (wherein the compounds of the above general formula I and salts, derivatives or analogs thereof, solvates thereof, water Japanese, polymorphic and prodrugs are in racemic form , In the form of pure enantiomers and / or diastereomers, or in the form of enantiomers and / or mixtures of diastereomers, or may be present in the form of tautomers). A novel pyrido [2,3-b] pyrazine derivative represented by the general formula (II) according to claim 12, wherein the substituents R1 to R4 have the following meanings:
R1 and R2, independently of one another, denote hydrogen or NR5R6, provided that when R1 is NR5R6, R2 is H and when R2 is NR5R6, R1 is H;
Wherein R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, the alkyl substituent as defined above, A cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent or alkyl-heteroaryl substituent is again on that side, F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , NO ₂ , SH, S-alkyl, OH, OCF ₃ , O (-alkyl-O ) _p - alkyl, O- aryl, OSO ₃ H, OP ( _{) (OH) 2, OP (} O) (O _{-alkyl) 2, OP (O) (} O _{aryl) 2, CHO, C (O} ) OH, C (O) NH 2, C (O) OR12, C (O ) NHR12, C (O) NR12R13 , SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (O -alkyl) _2, P (O) (O aryl) _2, Alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, which may be the same or different, mono- or poly-substituted, and p may have a value of 0, 1, 2, 3, 4 or 5; And the radicals R12 and R13, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl- It may be heteroaryl, or R12 and R13, taken together, may form a heterocyclyl ring;
R6 may mean -C (O) NR9-Y-R10, wherein Y may be O or NR11, independently of each other;
R9 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, and the alkyl substituent, cycloalkyl substituent, A heterocyclyl substituent, an aryl substituent and a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted on that side;
R10 and R11, independently of one another, can have the following meanings:
hydrogen,
Unsubstituted or substituted alkyl,
Unsubstituted or substituted cycloalkyl,
Unsubstituted or substituted heterocyclyl,
In this case, the heterocyclyl group is OH, O-alkyl, O-aryl, NH ₂ , NH-alkyl, NH-aryl, alkyl, alkyl-aryl or aryl, which are the same or different and mono- or poly-substituted. May be;
Unsubstituted or substituted aryl,
In this case, the aryl group includes F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH- alkyl - cycloalkyl, NH- alkyl - heterocyclyl, NH- alkyl - aryl, NH- alkyl - heteroaryl, NH- alkyl -NH _2, NH- alkyl -OH, N (alkyl) _2, NHC (O) - Alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC ( O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heteroaryl Krill, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- cycloalkyl, S- heterocyclyl, S- aryl, S- heteroaryl, OH, OCF _3, O (- alkyl -O) _p - alkyl, O-R38, O- cycloalkyl, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - cycloalkyl, O- alkyl - heterocyclyl, O- alkyl - aryl, O- alkyl - heteroaryl, O- alkyl _{-OH, O (CH 2) n} -O, OC (O) - alkyl, OC (O) -R38, OC ( O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroary , OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OSO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl , OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, C (O) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ H , CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C ( O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl , C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , SO-alkyl, SO-aryl, SO ₂ -alkyl, SO ₂ -aryl, SO ₂ NH ₂ , SO ₂ NH - alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl, SO ₂ O-alkyl - aryl Alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted, where p takes the value 0, 1, 2, 3, 4 or 5. And n can be 1, 2 or 3;
Unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may be F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl. , NH- alkyl - cycloalkyl, NH- alkyl - heterocyclyl, NH- alkyl - aryl, NH- alkyl - heteroaryl, NH- alkyl -NH _2, NH- alkyl -OH, N (alkyl) _2, NHC (O) -Alkyl, NH (O) -R38, NHC (O) -cycloalkyl, NHC (O) -heterocyclyl, NHC (O) -aryl, NHC (O) -heteroaryl, NHC (O) -alkyl-aryl, NHC (O) - alkyl - heteroaryl, NHSO ₂ - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - Heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- aryl, S- heteroaryl, OH, OCF ₃ , O (-alkyl-O) _p -alkyl, O-R38, O-cycloalkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl -Aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -Heteroaryl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, SO ₃ H, OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) _{(OH) 2, C (O} ) - alkyl, C (O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - heteroaryl, C (O) -NH ₂ , C (O) NH-alkyl, C (O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl , C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cycloalkyl, C (O) NH-alkyl-heterocyclyl, C (O) NH-alkyl-aryl, C (O) NH-alkyl-heteroaryl, C (O) N (alkyl) ₂ , C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) _{) 2, SO 2 NH 2,} SO 2 NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl , SO ₂ O-alkyl - aryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, same or different, it may be mono- or polysubstituted, in which p may take the values of 0, 1, 2 or 5;
Or R10 and R11 can be taken together to form a heterocyclyl ring,
R3 and R4 may have the following meanings independently of each other:
hydrogen,
Hydroxyl,
Halogens such as fluorine, chlorine, bromine, iodine,
Unsubstituted or substituted alkyl,
In this case, the alkyl group includes F, Cl, Br, I, CN, CF ₃ , NH ₂ , NH-alkyl, NH-aryl, N (alkyl) ₂ , SH, S-alkyl, OH, OCF ₃ , O (- alkyl -O) _p - alkyl, O- _{aryl, OSO 3 H, OP (O} ) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C ( O) OH, C (O) OR14, C (O) NH 2, C (O) NHR14, C (O) NR14R15, SO 3 H, SO 2 alkyl, SO ₂ aryl, P (O) (OH) 2, P (O) (Oalkyl) ₂ , P (O) (Oaryl) ₂ , cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different and mono- or polysubstituted, where p Is 0, 1, 2, 3, 4 or 5 And the groups R14 and R15, independently of one another, are alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, Well, or R14 and R15 can be taken together to form a heterocyclyl ring;
Unsubstituted or substituted aryl,
In this case, the aryl group includes F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NR20-alkyl, NHC (O) -alkyl, NHC (O) -R38, NR19 (O) -alkyl, NHC (O) -cycloalkyl, NR19C (O) -cycloalkyl, NHC (O) -heterocyclyl, NR19C (O) -heterocyclyl, NHC (O) -aryl, NR19C (O) -aryl, NHC (O) -heteroaryl, NR19C (O) -heteroa NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NHC (O) -alkyl-aryl, NR19C (O) -alkyl-aryl, NHC (O) -alkyl-heteroaryl, NR19C (O) - alkyl - heteroaryl, NR18C (O) O-R19 , NR18C (O) NR18R18, NHSO 2 - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl , NHSO ₂ -alkyl-heterocyclyl, NHSO ₂ -alkyl-aryl, NHSO ₂ -alkyl-heteroaryl, NO ₂ , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF ₃ , O-alkyl, O-R38, O-cycloal Le, O- heterocyclyl, O- aryl, O- heteroaryl, O- alkyl - cycloalkyl, O- alkyl - heterocyclyl, O- alkyl - aryl, O- alkyl - heteroaryl, O- (CH _{2) n} -O , OC (O) -alkyl, OC (O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O)- Alkyl-cycloalkyl, OC (O) -alkyl-heterocyclyl, OC (O) -alkyl-aryl, OC (O) -alkyl-heteroaryl, OC (O) O-R19, OC (O) NR18R18, OSO ₃ H , OSO ₂ - alkyl, OSO ₂ - cycloalkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C (O) - alkyl , C (O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - hetero aryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C ( O) NH-R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH- Alkyl - cycloalkyl, C (O) NH- alkyl - heterocyclyl, C (O) NH- alkyl - aryl, C (O) NH- alkyl - heteroaryl, C (O) N (alkyl) _2, C (O) N (cycloalkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , C (O) NR20-alkyl, C (O) NR19-alkyl-R21, -C (O ) NR18O-R18, -C (O ) NR18NR18R18, SO- alkyl, SO- aryl, SO ₂ - alkyl, SO ₂ - _{aryl, SO 2 NH 2, SO 2} NH- alkyl, SO ₂ NH- aryl, SO ₂ NH - heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl, SO ₂ O-aryl, SO ₂ O-alkyl - aryl, alkyl, alkylene -Cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or polysubstituted and n is 1, 2 or 3 and the alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl substituent, alkyl-cycloalkyl substituent, alkyl-heterocyclyl substituent, alkyl-aryl substituent. Groups and alkyl-heteroaryl substituents may be substituted again on that side;
Unsubstituted or substituted heteroaryl,
In this case, the heteroaryl group may be F, Cl, Br, I, CF ₃ , CN, NH ₂ , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl. , NH-alkyl-cycloalkyl, NH-alkyl-heterocyclyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, N (alkyl) ₂ , N (aryl) ₂ , NR20-alkyl, NHC (O) -alkyl, NHC (O) -R38, NR19 (O) -alkyl, NHC (O) -cycloalkyl, NR19C (O) -cycloalkyl, NHC (O) -heterocyclyl, NR19C (O) -heterocyclyl, NHC (O) -aryl , NR19C (O) -aryl, NHC (O) -heteroaryl, NR19C (O) -he Roaryl, NR18C (O) -alkyl-cycloalkyl, NR18C (O) -alkyl-heterocyclyl, NHC (O) -alkyl-aryl, NR19C (O) -alkyl-aryl, NHC (O) -alkyl-heteroaryl, NR19C (O) - alkyl - heteroaryl, NR18C (O) O-R19 , NR18C (O) NR18R18, NHSO 2 - alkyl, NHSO ₂ - cycloalkyl, NHSO ₂ - heterocyclyl, NHSO ₂ - aryl, NHSO ₂ - heteroaryl, NHSO ₂ - alkyl - heterocyclyl, NHSO ₂ - alkyl - aryl, NHSO ₂ - alkyl - heteroaryl, NO _2, SH, S- alkyl, S- aryl, S- heteroaryl, OH, OCF _3, O- alkyl, O -R38, O-Siku Alkyl, O-heterocyclyl, O-aryl, O-heteroaryl, O-alkyl-cycloalkyl, O-alkyl-heterocyclyl, O-alkyl-aryl, O-alkyl-heteroaryl, OC (O) -alkyl, OC ( O) -R38, OC (O) -cycloalkyl, OC (O) -heterocyclyl, OC (O) -aryl, OC (O) -heteroaryl, OC (O) -alkyl-cycloalkyl, OC (O)- alkyl - heterocyclyl, OC (O) - alkyl - aryl, OC (O) - alkyl - heteroaryl, OC (O) O-R19 , OC (O) NR18R18, OSO 3 H, OSO 2 - alkyl, OSO ₂ - cyclo alkyl, OSO ₂ - heterocyclyl, OSO ₂ - aryl, OSO ₂ - heteroaryl, OSO ₂ - alkyl Le - aryl, OSO ₂ - alkyl - heteroaryl, OP (O) (OH) 2, OP (O) (O _{-alkyl) 2, OP (O) (} O aryl) _2, C (O) - alkyl, C ( O) - aryl, C (O) - heteroaryl, CO ₂ H, CO ₂ - alkyl, CO ₂ -R38, CO ₂ - cycloalkyl, CO ₂ - heterocyclyl, CO ₂ - aryl, CO ₂ - heteroaryl, CO ₂ - alkyl - cycloalkyl, CO ₂ - alkyl - heterocyclyl, CO ₂ - alkyl - aryl, CO ₂ - alkyl - _{heteroaryl, C (O) -NH 2,} C (O) NH- alkyl, C (O) NH -R38, C (O) NH-cycloalkyl, C (O) NH-heterocyclyl, C (O) NH-aryl, C (O) NH-heteroaryl, C (O) NH-alkyl-cyclo Alkyl, C (O) NH- alkyl - heterocyclyl, C (O) NH- alkyl - aryl, C (O) NH- alkyl - heteroaryl, C (O) N (alkyl) _2, C (O) N (cyclo Alkyl) ₂ , C (O) N (aryl) ₂ , C (O) N (heteroaryl) ₂ , C (O) NR20-alkyl, C (O) NR19-alkyl-R21, -C (O) NR18O- R18, -C (O) NR18NR18R18, SO 2 NH 2, SO 2 NH- alkyl, SO ₂ NH- aryl, SO ₂ NH- heteroaryl, SO ₂ NH- alkyl - aryl, SO ₃ H, SO ₂ O- alkyl , SO ₂ O-aryl, SO ₂ O-alkyl - aryl, alkyl, alkyl - cycloalkyl, alkyl - heterocyclyl, alkyl - aryl, alkyl - heteroar- , Cycloalkyl, heterocyclyl, aryl or heteroaryl, which may be the same or different, mono- or poly-substituted, and the alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent, heteroaryl Substituents, alkyl-cycloalkyl substituents, alkyl-heterocyclyl substituents, alkyl-aryl substituents and alkyl-heteroaryl substituents may be substituted again on that side;
OR29,
R29 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, and said alkyl substituent, cycloalkyl substituent A heterocyclyl substituent, an aryl substituent, a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted on that side;
SR30,
R30 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, and the alkyl substituent, cycloalkyl substituent. A heterocyclyl substituent, an aryl substituent and a heteroaryl substituent, an alkyl-cycloalkyl substituent, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted on that side;
NR31R32,
In this case, R 31 and R 32 are independently of each other hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl, alkyl-heteroaryl, —C (O) — R33, -SO ₂ R33, -C (O) OR33 and -C (O) may be -NR34R35, this time, R33 is alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl - cycloalkyl, alkyl -Heterocyclyl, alkyl-aryl, alkyl-heteroaryl and R34 and R35 independently of one another are hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-hetero Krill, alkyl - aryl, alkyl - may be a heteroaryl, or R34 and R35 taken together may form a heterocyclyl ring;
Or R31 and R32 can be taken together to form a heterocyclyl ring, and said alkyl substituent, cycloalkyl substituent, heterocyclyl substituent, aryl substituent and heteroaryl substituent, alkyl-cycloalkyl substituent A group, an alkyl-heterocyclyl substituent, an alkyl-aryl substituent or an alkyl-heteroaryl substituent may be substituted again on that side;
R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl,
R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl.
R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl,
R38 may be alkyl, wherein the alkyl group may be saturated or unsaturated, linear or branched, has ₉ to 30 carbon atoms, and is C 9- C ₃₀ -alkenyl has at least one C—C double bond, and C ₉ -C ₃₀ -alkynyl has at least one C—C triple bond, wherein said alkenyl is Physiologically tolerable pyrido [2,3-b] pyrazine derivatives and compounds of formula I, characterized in that they may exist in the (E) configuration or in the (Z) configuration And solvates, hydrates, polymorphs and prodrugs thereof (wherein the compounds of general formula I and salts, derivatives or analogs thereof, solvates, hydration thereof) Products, polymorphs and prodrugs in their racemic form In the form of pure enantiomers and / or diastereomers, or in the form of enantiomers and / or mixtures of diastereomers, or may be present in the form of tautomers).   A pyrido [2,3-b] pyrazine derivative represented by the general formula (II) according to claim 12 or 13, wherein R2 is H. .   A pyrido [2,3-b] pyrazine derivative represented by the general formula (II) according to claim 12 or 13, wherein R2 and R4 are H. Pyrazine derivative.   A pyrido [2,3-b] pyrazine derivative represented by the general formula (II) according to claim 12, wherein R2 and R4 are H, and R6 represents -C (Y) NR7R8. Wherein Y may be O or S, independently of one another, and R7 and R8 have the meanings given in claim 12 and are pyrido [2,3-b] pyrazine derivatives . The pyrido [2,3-b] pyrazine derivative represented by the general formula (II) according to claim 12 or 13, wherein the alkyl group is methyl, ethyl, n-propyl, 2-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, 2-hexyl, n-octyl, ethylenyl (vinyl), ethynyl, propenyl (—CH ₂ CH═CH ₂ ; —CH═CH— CH ₃ , —C (═CH ₂ ) —CH ₃ ), propynyl (—CH ₂ —C≡CH, —C≡C—CH ₃ ), butenyl, butynyl, pentenyl, pentynyl, hexenyl, hexynyl, heptenyl, heptynyl, A pyrido [2,3-b] pyrazine derivative characterized in that it may be octenyl or octynyl.   The pyrido [2,3-b] pyrazine derivative represented by the general formula (II) according to claim 12 or 13, wherein the heterocyclyl group is tetrahydrofuryl, pyrrolidinyl, imidazolidinyl, thiazolidinyl, tetrahydropyranyl, piperidinyl, piperazinyl And a pyrido [2,3-b] pyrazine derivative, characterized in that it may be morpholinyl.   The pyrido [2,3-b] pyrazine derivative represented by the formula (II) according to claim 12 or 13, wherein the heteroaryl group is pyrrolyl, furyl, thienyl, thiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, pyrazolyl, Imidazolyl, triazole, tetrazole, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazine, phthalazinyl, indolyl, indazolyl, indolizinyl, quinolinyl, isoquinolinyl, quinoxalinyl, quinazolinyl, pteridinyl, carbazolyl, phenazinyl, phenoxazinyl and phenoxazinyl A featured pyrido [2,3-b] pyrazine derivative. A pyrido [2,3-b] pyrazine derivative represented by the general formula (I) or (II) according to any one of claims 1 to 19, comprising the following compounds 1 to 85:
Compound 1 1-ethyl-3- (3-phenylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 2 1-ethyl-3- (3-thiophen-3-ylethynyl-pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 3 1- (3-Cyclopropylethynyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea

Compound 4 1- [3- (3-Dimethylamino-prop-1-ynyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 5 1- [3-((E) -2-cyclohexyl-vinyl) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 6 1-ethyl-3- [3-((E) -3-methoxy-propenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 7

Compound 8

Compound 9 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester methyl ester

Compound 10 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester

Compound 11 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester Phenyl ester

Compound 12 Diethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 13 (E) -3-Phenyl-acrylic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 14 Nonadecanoic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 15 1- (3-Benzyl-pyrido [2,3-b] pyrazin-6-yl) -3-ethyl-urea

Compound 16 Carbonic acid 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester

Compound 17 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester isobutyl ester

Compound 18 Carbonic acid but-2-ynyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 19 Dimethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 20 Ethyl-carbamic acid 4- [6- (3-ethyl-1-phenyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 21 {4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid t-butyl ester

Compound 22 {4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -carbamic acid 2-methoxy-ethyl ester

Compound 23 1-ethyl-3- {3- [4- (3-ethyl-urea) -phenyl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 24 1- {3- [4- (3,3-Dimethyl-urea) -phenyl] -pyrido [2,3-b] pyrazin-6-yl} -3-ethyl-urea

Compound 25 1-ethyl-3- {3- [6- (3-ethyl-urea) -pyridin-3-yl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 26 1-ethyl-3- {3- [2- (4-fluoro-phenyl) -ethyl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 27 1-ethyl-3- {3-[(E) -2- (4-fluoro-phenyl) -vinyl] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 28 1-ethyl-3- [3- (4-morpholin-4-ylmethyl-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 29 1-ethyl-3- (3- {4- [2- (2-methoxy-ethoxy) -ethoxy] -phenyl} -pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 30 N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -2- (2-methoxy-ethoxy) -acetamide

Compound 31 N- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -4-methyl-benzamide

Compound 32 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester 2-methoxy-ethyl ester

Compound 33 Carbonic acid 2-benzyloxy-ethyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester

Compound 34 Carbonic acid 2-benzyloxy-ethyl ester 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester

Compound 35 2-Benzyloxy-N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl} -acetamide

Compound 36 1- [4- (t-Butyl-dimethyl-silanyloxy) -butyl] -3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea

Compound 37 1- [4- (t-Butyl-dimethyl-silanyloxy) -butyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl ] -Urea

Compound 38 Ethyl-carbamic acid 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 39 Carbonic acid methyl ester 4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 40 Carbonic acid 2,2-dimethyl- [1,3] dioxolan-4-ylmethyl ester 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 41 Carbonic acid 2,3-dihydroxy-propyl ester 4- [3- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl ester

Compound 42 {4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphoric acid diethyl ester

Compound 43 {4- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -butyl} -phosphate

Compound 44 (4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea} -butyl) -phosphoric acid diethyl ester

Compound 45 (4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea} -butyl) -phosphoric acid

Compound 46 1-ethyl-3- [3- (3-trimethylsilanyl-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 47 1- [3- (4-cyclohexyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 48 1-ethyl-3- [3- (4-methanesulfonyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 49 N- {5- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -2-methyl-phenyl} -methanesulfonamide

Compound 50 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -N-methyl-benzamide

Compound 51 1-ethyl-3- [3- (4-piperidin-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 52 1-ethyl-3- [3- (4-thiophen-3-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 53 N- {4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -phenyl} -acetamide

Compound 54 3- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-ylamino] -benzoic acid ethyl ester

Compound 55 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester hydrochloride

Compound 56 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -phenyl ester 2-methoxy-ethyl ester p-toluenesulfonate

Compound 57 Carbonic acid 4- {6- [3- (4-hydroxy-butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester

Compound 58 Carbonic acid 4- {6- [3- (4-hydroxy-butyl) -urea] -pyrido [2,3-b] pyrazin-3-yl} -phenyl ester 2-methoxy-ethyl ester hydrochloride

Compound 59 N- (3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalic acid monoamide ethyl ester

Compound 60 N-ethyl-N '-(3-phenyl-pyrido [2,3-b] pyrazin-6-yl) -oxalamide

Compound 61

Compound 62 {2- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -ethyl} -phosphoric acid diethyl ester

Compound 63 {2- [3- (3-Phenyl-pyrido [2,3-b] pyrazin-6-yl) -urea] -ethyl} -phosphate

Compound 64 1- [3- (2-Diethylamino-ethoxy) -propyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- urea

Compound 65 2,2-dimethyl-propanoic acid (2,2-dimethyl-propionyloxymethoxy)-(4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b ] Pyrazin-6-yl] -urea} -butyl) -phosphinoyloxymethyl ester

Compound 66 Acetic acid 1-[(1-acetoxy-ethoxy)-(4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- Urea} -butyl) -phosphinoyloxy] -ethyl ester

Compound 67 Diethyl-carbamic acid 4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester

Compound 68 Diethyl-carbamic acid 2-chloro-4- [6- (3-ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -6-methoxy-phenyl ester

Compound 69 Carbonic acid 4- [6- (3-Ethyl-urea) -pyrido [2,3-b] pyrazin-3-yl] -2-methoxy-phenyl ester 2- [2- (2-methoxy-ethoxy)- Ethoxy] -ethyl ester

Compound 70 1-ethyl-3- {3- [4- (morpholine-4-sulfonyl) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 71 5- [6- (3-Ethyl-ureido) -pyrido [2,3-b] pyrazin-3-ylamino] -2-hydroxy-benzoic acid ethyl ester

Compound 72 1- [3- (3-Diethylaminomethyl-4-hydroxy-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -3-ethyl-urea

Compound 73 1-ethyl-3- [3- (6-morpholin-4-yl-pyridin-3-ylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 74 1-ethyl-3- {3- [3- (1H-tetrazol-5-yl) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 75 1-ethyl-3- [3- (3-morpholin-4-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 76 1-ethyl-3- [3- (4-imidazol-1-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 77 1-ethyl-3- [3- (4-pyrrolidin-1-yl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 78 1-ethyl-3- {3- [4- (4-methyl-piperazin-1-yl) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -urea

Compound 79 1-ethyl-3- [3- (3-piperidin-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 80 1-ethyl-3- [3- (4-morpholin-4-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 81 1- {3- [3- (2-cyclohexyl-ethoxy) -phenylamino] -pyrido [2,3-b] pyrazin-6-yl} -3-ethyl-urea

Compound 82 1-ethyl-3- [3- (3- [1,2,4] triazol-1-ylmethyl-phenylamino) -pyrido [2,3-b] pyrazin-6-yl] -urea

Compound 83 Carbonic acid 2,2-dimethyl- [1,3] dioxolan-4-ylmethyl ester 4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazine -6-yl] -ureido} -butyl ester

Compound 84 Carbonic acid 2,3-dihydroxy-propyl ester 4- {3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl] -ureido} -butyl ester

Compound 85 1- [3- (2-Diethylamino-ethoxy) -propyl] -3- [3- (4-hydroxy-3-methoxy-phenyl) -pyrido [2,3-b] pyrazin-6-yl]- urea

A pyrido [2,3-b] pyrazine derivative characterized by being selected from:   A pharmaceutical comprising at least one pyrido [2,3-b] pyrazine derivative according to any one of claims 1 to 20.   22. A pharmaceutical product according to claim 21, wherein the pyrido [2,3-b] pyrazine derivative is converted to at least one other pharmaceutically active substance and / or pharmaceutically acceptable carrier substance and / or Pharmaceutical product characterized by containing in combination with auxiliary substances.   23. The method for producing a pharmaceutical product according to claim 21 or 22, wherein the one or more pyrido [2,3-b] pyrazine derivatives according to any one of claims 1 to 20 are pharmaceutically acceptable. A pharmaceutical preparation process characterized in that it is processed together with a carrier substance and / or an auxiliary substance to form a pharmaceutical preparation or a therapeutically usable form.   21. A compound according to any one of claims 1 to 20 for use as a medicament.   21. A compound according to any one of claims 1 to 20, for active and inactive receptor tyrosine kinases and for cytoplasmic tyrosine kinases for the modulation of cellular pathways of wrong pathways. Serine / threonine kinases and lipid kinases such as c-Raf, B-Raf, Mek, MAPKs, PDGFRβ, Flt-3, IGF1R, PI3K, PKB / Akt1, c -Use of kits, c-Abl, FGFR1 and KDR for the production of pharmaceuticals to affect the function.   21. A compound according to any one of claims 1 to 20 from the group consisting of "ras-Raf-Mek-Erk-signaling pathway, PI3K-Akt-signaling pathway and / or SAPK-signaling pathway". Use for the manufacture of a medicament for the treatment or prevention of a physiological and / or pathological condition in a mammal mediated by a selected signaling pathway.   27. Use of a compound according to any one of claims 1 to 20, 26, wherein the treatment or prevention comprises the "ras-Raf-Mek-Erk-signaling pathway, PI3K-Akt-signaling pathway and / SAPK. -Use characterized by the modulation of one or more signal transduction pathways selected from the group consisting of "signal transduction pathways".   27. Use according to any one of claims 1 to 20, 26, wherein the physiological and / or pathophysiological condition consists of "ATM, ATR, mTOR, DNA-PK, hSMG-1". Use characterized in that it is mediated by an enzyme selected from the group.   29. Use according to any one of claims 1 to 20, 26, 28, wherein the treatment or prevention is selected from the group consisting of "ATM, ATR, mTOR, DNA-PK, hSMG-1" Use characterized by being brought about by the modulation of two or more enzymes.   28. Use according to any one of claims 1 to 20, 26, 27, wherein the mediated and / or regulated signaling pathway is ras-Raf-Mek-Erk-signaling pathway and PI3K- Use characterized by being the Akt-signaling pathway.   28. Use according to any one of claims 1 to 20, 26, 27, wherein the mediated and / or regulated signaling pathway is a ras-Raf-Mek-Erk-signaling pathway. Use characterized by.   28. Use according to any one of claims 1 to 20, 26, 27, characterized in that the mediated and / or regulated signaling pathway is a PI3K-Akt-signaling pathway. use.   28. Use according to any one of claims 1 to 20, 26, 27, wherein the mediated and / or regulated signaling pathway is a SAPK-signaling pathway and a PI3K-Akt-signaling pathway. Use characterized by being.   28. Use according to any one of claims 1 to 20, 26, 27, characterized in that the mediated and / or regulated signaling pathway is a SAPK-signaling pathway.   32. Use according to any one of claims 1 to 20, 26, 27, 30, 31 wherein the modulation of the ras-Raf-Mek-Erk-signaling pathway is "tyrosine kinase, serine / threonine kinase, Use characterized in that it is effected by the modulation of one or more enzymes selected from the group consisting of receptor tyrosine kinases, cytoplasmic tyrosine kinases, cytoplasmic serine / threonine kinases.   36. Use according to claim 35, characterized in that the enzyme is selected from the group consisting of "Erk, Erk1, Erk2".   34. Use according to any one of claims 1 to 20, 26, 27, 30, 32, 33, wherein the modulation of the PI3K-Akt-signaling pathway is "PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, Use characterized by being brought about by the modulation of one or more enzymes selected from the group consisting of PI3K-C2α, PI3K-C2β, PI3K-Vps34p ".   35. Use according to any one of claims 1 to 20, 26, 27, 33, 34, wherein the modulation of the SAPK-signaling pathway is "tyrosine kinase, serine / threonine kinase, receptor tyrosine kinase, cytoplasm" Use characterized in that it is effected by the modulation of one or more enzymes selected from the group consisting of "tyrosine kinase, cytoplasmic serine / threonine kinase".   40. Use according to claim 38, characterized in that the enzyme is selected from the group consisting of “Jnk, Jnk1, Jnk2, Jnk3, p38, p38α, p38β, p38γ, p38δ”.   40. Use according to any one of claims 1 to 20, 25 to 39, characterized in that two or more enzymes are prepared.   41. Use according to claim 40, wherein the at least one enzyme is selected from the group consisting of "Erk, Erk1, Erk2" and at least one enzyme is "PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K". -Use characterized in that it is selected from the group consisting of C2α, PI3K-C2β, PI3K-Vps34p ".   41. Use according to claim 40, wherein the at least one enzyme is selected from the group consisting of "Jnk, Jnk1, Jnk2, Jnk3, p38, p38α, p38β, p38γ, p38δ" and at least one enzyme is Use characterized in that it is selected from the group consisting of "PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K-C2α, PI3K-C2β, PI3K-Vps34p".   41. Use according to claim 40, wherein the at least one enzyme is selected from the group consisting of "Erk, Erk1, Erk2" and the at least one enzyme is "ATM, ATR, mTOR, DNA-PK, hSMG". Use characterized in that it is selected from the group consisting of -1 ".   41. Use according to claim 40, wherein the at least one enzyme is selected from the group consisting of "Jnk, Jnk1, Jnk2, Jnk3, p38, p38α, p38β, p38γ, p38δ" and at least one enzyme is Use characterized in that it is selected from the group consisting of "ATM, ATR, mTOR, DNA-PK, hSMG-1".   41. Use according to claim 40, wherein the at least one enzyme is selected from the group consisting of "PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K-C2α, PI3K-C2β, PI3K-Vps34p" and at least one Use wherein the two enzymes are selected from the group consisting of "ATM, ATR, mTOR, DNA-PK, hSMG-1".   46. Use according to any one of claims 1 to 20, 25 to 45, characterized in that the adjustment is an inhibition.   The use according to any one of claims 1 to 20, 26 to 46, wherein the mammal is "human, useful animal, domestic animal, pet, cow, cow, sheep, pig, goat, horse, pony" , Donkey, mule, mule, rabbit, domestic rabbit, cat, dog, guinea pig, hamster, rat, mouse, use characterized in that it is preferably a human.   48. Use according to any one of claims 1 to 20, 26 to 47, wherein the physiological and / or pathophysiological state is "malignant tumor, benign tumor, inflammatory disease, inflammation, pain, Rheumatoid disease, arthritic disease, HIV infection, neurological or neurodegenerative disease, rheumatism, arthritis, AIDS, ARC (AIDS-related syndrome), Kaposi's sarcoma, brain and / or nervous system and / or tumor starting from the brain membrane , Dementia, Alzheimer, hyperproliferative disease, psoriasis, endometriosis, scar formation, benign prostatic hypertrophy (BPH), immune system disease, autoimmune disease, immunodeficiency disease, colon tumor, stomach tumor, intestinal tumor, lung tumor , Pancreatic tumor, ovarian tumor, prostate tumor, leukemia, melanoma, liver tumor, kidney tumor, head tumor, cervical tumor, glioma, breast cancer, uterine cancer, endometrial cancer, cervical cancer, brain tumor, adenocanto , Bladder cancer, stomach tumor, colorectal tumor, esophageal cancer, gynecological tumor, ovarian tumor, thyroid cancer, lymphoma, chronic leukemia, acute leukemia, restenosis, diabetes, diabetic nephropathy, fibrotic disease, cyst Fibrosis, malignant nephrosclerosis, thrombotic microvascular syndrome, organ graft-rejection, glomerulopathy, metabolic disease, solid tumor, rheumatoid arthritis, diabetic retinopathy, asthma, allergy, allergic disease, Chronic obstructive pulmonary disease, inflammatory bowel disease, fibrosis, atherosclerosis, heart disease, cardiovascular disease, myocardial disease, vascular disease, angiogenic disease, kidney disease, rhinitis, severe disease, focal ischemia , Heart failure, ischemia, cardiac hypertrophy, renal failure, cardiomyocyte dysfunction, hypertension, vascular stenosis, stroke, anaphylactic shock, platelet coagulation, skeletal muscle atrophy, adiposity, overweight, glucose homeostasis, congestive heart failure, narrow Disease, heart attack, myocardial infarction, hyperglycemia, use hypoglycemia, characterized in that it is selected from the group consisting of hypertension "is.   49. Use according to any one of claims 1 to 22, 24, 26 to 48, characterized in that the medicament comprises at least one other pharmacologically active substance.   49. Use according to any one of claims 1 to 22, 24, 26 to 48, wherein the medicament is at least one other pharmacologically effective before and / or during and / or after treatment. Use characterized in that it is administered together with a substance.   49. Use according to any one of claims 1 to 22, 24, 26 to 48, wherein the medicament is administered with radiation therapy and / or surgery before and / or during and / or after treatment. Use characterized by that.   51. Use according to any one of claims 49 to 50, wherein the other pharmacologically effective substances are "DNA topoisomerase I and / or II inhibitors, DNA intercalators, alkylating agents, microtubules". Characterized in that it is selected from the group consisting of destabilizing agents, hormone receptors and / or growth factor receptors-agonists and / or antagonists, growth factors and antibodies to the receptors, kinase inhibitors, antimetabolites Use to.   53. The use according to any one of claims 49, 50, 52, wherein the other pharmacologically effective substance is "asparaginase, bleomycin, carboplatin, carmustine, chlorambucil, cisplatin, cholaspase, cyclophosphamide" , Cytarabine, dacarbazine, dactinomycin, daunorubicin, doxorubicin (adriamycin), epirubicin, etoposide, 5-fluorouracil, hexamethylmelamine, hydroxyurea, ifosfamide, irinotecan, leucovorin, lomustine, mechlorethamine, 6-mercaptopurine, mesna, methotrex Mitomycin C, mitoxantrone, prednisolone, prednisone, procarbazine, raloxifene, streptozocin, tamoxifen, thioguanine, Topotecan, vinblastine, vincristine, vindesine, aminoglutethimide, L-asparaginase, azathioprine, 5-azacytidine, cladribine, busulfan, diethylstilbestrol, 2 ', 2'-difluorodeoxycytidine, docetaxel, erythrohydroxynonyladenine, ethynyl Estradiol, 5-fluorodeoxyuridine, 5-fluorodeoxyuridine monophosphate, fludarabine phosphate, fluoxymesterone, flutamide, hydroxyprogesterone caproate, idarubicin, interferon, medroxyprogesterone acetate, megestrol acetate, melphalan, Mittan, paclitaxel, oxaliplatin, pentostatin, N-phosphonoacetyl-L-aspartate (PAL ), Pricamycin, semustine, teniposide, testosterone propionate, thiotepa, trimethylmelamine, uridine, vinorelbine, epothilone, gemcitabine, taxotere, BCNU, CCNU, DTIC, 5-fluorouracil, herceptin, avastin, erbitux, sorafenib, glibec Use characterized in that it is selected from the group consisting of Iressa, Tarceva, Rapamycin, Actinomycin D ".   21. A pharmaceutical composition comprising a pharmacologically effective amount of at least one compound according to any one of claims 1-20.   55. The pharmaceutical composition according to claim 54, wherein the agent is present in a unit dose of 0.001 mg to 100 mg per kg patient body weight.   56. A pharmaceutical composition according to any one of claims 54 to 55, which composition further comprises at least one pharmaceutically acceptable carrier substance and / or auxiliary substance. A pharmaceutical composition characterized.   57. Use according to any one of claims 54 to 56, characterized in that the composition contains at least one other pharmacologically active agent.   58. The pharmaceutical composition according to claim 57, wherein the other pharmacologically effective substance is “DNA topoisomerase I and / or II inhibitor, DNA intercalator, alkylating agent, microtubule destabilizing agent, hormone. A pharmaceutical composition, characterized in that it is selected from the group consisting of receptor and / or growth factor receptor-agonist and / or antagonist, growth factor and antibody to the receptor, kinase inhibitor, antimetabolite ".   59. The pharmaceutical composition according to any one of claims 57 to 58, wherein the other pharmacologically effective substance is "asparaginase, bleomycin, carboplatin, carmustine, chlorambucil, cisplatin, cholaspase, cyclophosphamis" Do, cytarabine, dacarbazine, dactinomycin, daunorubicin, doxorubicin (adriamycin), epirubicin, etoposide, 5-fluorouracil, hexamethylmelamine, hydroxyurea, ifosfamide, irinotecan, leucovorin, lomustine, mechlorethamine, 6-mercaptopurine, mesna, methotrexate Mitomycin C, mitoxantrone, prednisolone, prednisone, procarbazine, raloxifene, streptozocin, tamoxifen, thiogua Nin, topotecan, vinblastine, vincristine, vindesine, aminoglutethimide, L-asparaginase, azathioprine, 5-azacytidine, cladribine, busulfan, diethylstilbestrol, 2 ', 2'-difluorodeoxycytidine, docetaxel, erythrohydroxynonyladenine , Ethinylestradiol, 5-fluorodeoxyuridine, 5-fluorodeoxyuridine monophosphate, fludarabine phosphate, fluoxymesterone, flutamide, hydroxyprogesterone caproate, idarubicin, interferon, medroxyprogesterone acetate, megestrol acetate, mel Faran, mitotane, paclitaxel, oxaliplatin, pentostatin, N-phosphonoacetyl-L-aspartate ( ALA), pricamycin, semustine, teniposide, testosterone propionate, thiotepa, trimethylmelamine, uridine, vinorelbine, epothilone, gemcitabine, taxotere, BCNU, CCNU, DTIC, 5-fluorouracil, herceptin, avastin, erbitux, sorafenib, sorafenib , Iressa, Tarceva, rapamycin, actinomycin D ″.   60. A pharmacologically effective amount of at least one compound according to any one of claims 1 to 20 and at least one other pharmacological agent according to any one of claims 57 to 59. And a pharmacologically effective amount of an active agent.