JP2009515850A - モノアミン神経伝達物質再取り込み阻害薬としての８−アザ−ビシクロ［３．２．１］オクタン誘導体及びそれらの使用 - Google Patents
モノアミン神経伝達物質再取り込み阻害薬としての８−アザ−ビシクロ［３．２．１］オクタン誘導体及びそれらの使用 Download PDFInfo
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- UOUFRTFWWBCVPV-UHFFFAOYSA-N tert-butyl 4-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CC1)n1c(=O)[nH]c2ccsc2c1=O UOUFRTFWWBCVPV-UHFFFAOYSA-N 0.000 description 1
- GDYVHALUVFLVMF-UHFFFAOYSA-N tert-butyl 8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1CCC2CCC1N2C(=O)OC(C)(C)C GDYVHALUVFLVMF-UHFFFAOYSA-N 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- KRIIYLYFQJZIEH-UHFFFAOYSA-N trichloromethyl 3-benzoyloxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound ClC(Cl)(Cl)OC(=O)N1C(C2)CCC1CC2OC(=O)C1=CC=CC=C1 KRIIYLYFQJZIEH-UHFFFAOYSA-N 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
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- Pain & Pain Management (AREA)
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- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501565 | 2005-11-11 | ||
| US73633005P | 2005-11-15 | 2005-11-15 | |
| PCT/EP2006/068275 WO2007054531A1 (en) | 2005-11-11 | 2006-11-09 | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515850A true JP2009515850A (ja) | 2009-04-16 |
| JP2009515850A5 JP2009515850A5 (enExample) | 2009-09-03 |
Family
ID=38654732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539435A Abandoned JP2009515850A (ja) | 2005-11-11 | 2006-11-09 | モノアミン神経伝達物質再取り込み阻害薬としての８−アザ−ビシクロ［３．２．１］オクタン誘導体及びそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8110586B2 (enExample) |
| EP (1) | EP1948653A1 (enExample) |
| JP (1) | JP2009515850A (enExample) |
| CN (1) | CN101277954A (enExample) |
| AR (1) | AR056804A1 (enExample) |
| AU (1) | AU2006311013A1 (enExample) |
| BR (1) | BRPI0617181A2 (enExample) |
| CA (1) | CA2629237A1 (enExample) |
| TW (1) | TW200804367A (enExample) |
| WO (1) | WO2007054531A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007063210A1 (de) * | 2007-12-20 | 2009-06-25 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung von Phantomphänomenen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA971525B (en) | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| WO2004113334A1 (en) * | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
2006
- 2006-10-18 TW TW095138357A patent/TW200804367A/zh unknown
- 2006-11-09 EP EP06819353A patent/EP1948653A1/en not_active Withdrawn
- 2006-11-09 AU AU2006311013A patent/AU2006311013A1/en not_active Abandoned
- 2006-11-09 WO PCT/EP2006/068275 patent/WO2007054531A1/en not_active Ceased
- 2006-11-09 JP JP2008539435A patent/JP2009515850A/ja not_active Abandoned
- 2006-11-09 CN CNA2006800364675A patent/CN101277954A/zh active Pending
- 2006-11-09 CA CA002629237A patent/CA2629237A1/en not_active Abandoned
- 2006-11-09 BR BRPI0617181-8A patent/BRPI0617181A2/pt not_active Application Discontinuation
- 2006-11-09 US US11/992,836 patent/US8110586B2/en not_active Expired - Fee Related
- 2006-11-10 AR ARP060104940A patent/AR056804A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR056804A1 (es) | 2007-10-24 |
| AU2006311013A1 (en) | 2007-05-18 |
| EP1948653A1 (en) | 2008-07-30 |
| WO2007054531A1 (en) | 2007-05-18 |
| US8110586B2 (en) | 2012-02-07 |
| TW200804367A (en) | 2008-01-16 |
| US20100267764A1 (en) | 2010-10-21 |
| CN101277954A (zh) | 2008-10-01 |
| BRPI0617181A2 (pt) | 2011-07-12 |
| CA2629237A1 (en) | 2007-05-18 |
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