JP2009515850A - モノアミン神経伝達物質再取り込み阻害薬としての８−アザ−ビシクロ［３．２．１］オクタン誘導体及びそれらの使用 - Google Patents
モノアミン神経伝達物質再取り込み阻害薬としての８−アザ−ビシクロ［３．２．１］オクタン誘導体及びそれらの使用 Download PDFInfo
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- UOUFRTFWWBCVPV-UHFFFAOYSA-N tert-butyl 4-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CC1)n1c(=O)[nH]c2ccsc2c1=O UOUFRTFWWBCVPV-UHFFFAOYSA-N 0.000 description 1
- GDYVHALUVFLVMF-UHFFFAOYSA-N tert-butyl 8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1CCC2CCC1N2C(=O)OC(C)(C)C GDYVHALUVFLVMF-UHFFFAOYSA-N 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- KRIIYLYFQJZIEH-UHFFFAOYSA-N trichloromethyl 3-benzoyloxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound ClC(Cl)(Cl)OC(=O)N1C(C2)CCC1CC2OC(=O)C1=CC=CC=C1 KRIIYLYFQJZIEH-UHFFFAOYSA-N 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
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- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501565 | 2005-11-11 | ||
| US73633005P | 2005-11-15 | 2005-11-15 | |
| PCT/EP2006/068275 WO2007054531A1 (en) | 2005-11-11 | 2006-11-09 | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515850A true JP2009515850A (ja) | 2009-04-16 |
| JP2009515850A5 JP2009515850A5 (enExample) | 2009-09-03 |
Family
ID=38654732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539435A Abandoned JP2009515850A (ja) | 2005-11-11 | 2006-11-09 | モノアミン神経伝達物質再取り込み阻害薬としての８−アザ−ビシクロ［３．２．１］オクタン誘導体及びそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8110586B2 (enExample) |
| EP (1) | EP1948653A1 (enExample) |
| JP (1) | JP2009515850A (enExample) |
| CN (1) | CN101277954A (enExample) |
| AR (1) | AR056804A1 (enExample) |
| AU (1) | AU2006311013A1 (enExample) |
| BR (1) | BRPI0617181A2 (enExample) |
| CA (1) | CA2629237A1 (enExample) |
| TW (1) | TW200804367A (enExample) |
| WO (1) | WO2007054531A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007063210A1 (de) * | 2007-12-20 | 2009-06-25 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung von Phantomphänomenen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9707636A (pt) | 1996-02-22 | 1999-07-27 | Neurosearch As | Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivo |
| EP1638965A1 (en) | 2003-06-24 | 2006-03-29 | NeuroSearch A/S | Novel 8-aza-bicyclo¬3.2.1|octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
2006
- 2006-10-18 TW TW095138357A patent/TW200804367A/zh unknown
- 2006-11-09 CA CA002629237A patent/CA2629237A1/en not_active Abandoned
- 2006-11-09 EP EP06819353A patent/EP1948653A1/en not_active Withdrawn
- 2006-11-09 CN CNA2006800364675A patent/CN101277954A/zh active Pending
- 2006-11-09 AU AU2006311013A patent/AU2006311013A1/en not_active Abandoned
- 2006-11-09 JP JP2008539435A patent/JP2009515850A/ja not_active Abandoned
- 2006-11-09 WO PCT/EP2006/068275 patent/WO2007054531A1/en not_active Ceased
- 2006-11-09 US US11/992,836 patent/US8110586B2/en not_active Expired - Fee Related
- 2006-11-09 BR BRPI0617181-8A patent/BRPI0617181A2/pt not_active Application Discontinuation
- 2006-11-10 AR ARP060104940A patent/AR056804A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007054531A1 (en) | 2007-05-18 |
| AR056804A1 (es) | 2007-10-24 |
| CN101277954A (zh) | 2008-10-01 |
| AU2006311013A1 (en) | 2007-05-18 |
| US8110586B2 (en) | 2012-02-07 |
| CA2629237A1 (en) | 2007-05-18 |
| BRPI0617181A2 (pt) | 2011-07-12 |
| US20100267764A1 (en) | 2010-10-21 |
| EP1948653A1 (en) | 2008-07-30 |
| TW200804367A (en) | 2008-01-16 |
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