JP2009509979A5 - - Google Patents

Info

Publication number

JP2009509979A5

JP2009509979A5 JP2008532546A JP2008532546A JP2009509979A5 JP 2009509979 A5 JP2009509979 A5 JP 2009509979A5 JP 2008532546 A JP2008532546 A JP 2008532546A JP 2008532546 A JP2008532546 A JP 2008532546A JP 2009509979 A5 JP2009509979 A5 JP 2009509979A5

Authority

JP

Japan

Prior art keywords

serpin

granzyme

cell

composition

tissue

Prior art date

2006-09-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108050000761 Serpin Proteins 0.000 claims 12
• 102000008847 Serpin Human genes 0.000 claims 12
• 239000003001 serine protease inhibitor Substances 0.000 claims 12
• 239000000203 mixture Substances 0.000 claims 11
• 102000001398 Granzyme Human genes 0.000 claims 10
• 108060005986 Granzyme Proteins 0.000 claims 10
• 230000002401 inhibitory effect Effects 0.000 claims 10
• 241001465754 Metazoa Species 0.000 claims 9
• 230000009261 transgenic effect Effects 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 8
• 102000040430 polynucleotide Human genes 0.000 claims 8
• 108091033319 polynucleotide Proteins 0.000 claims 8
• 239000002157 polynucleotide Substances 0.000 claims 8
• 239000012634 fragment Substances 0.000 claims 6
• 210000001519 tissue Anatomy 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 claims 3
• 210000004153 islets of langerhan Anatomy 0.000 claims 3
• 241000251468 Actinopterygii Species 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 210000004962 mammalian cell Anatomy 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• 101000976075 Homo sapiens Insulin Proteins 0.000 claims 1
• 210000003527 eukaryotic cell Anatomy 0.000 claims 1
• 210000002216 heart Anatomy 0.000 claims 1
• 210000005003 heart tissue Anatomy 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• 210000004923 pancreatic tissue Anatomy 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1