JP2009505953A - リパーゼに媒介される疾患の処置のための化合物 - Google Patents

リパーゼに媒介される疾患の処置のための化合物 Download PDF

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Publication number
JP2009505953A
JP2009505953A JP2008522176A JP2008522176A JP2009505953A JP 2009505953 A JP2009505953 A JP 2009505953A JP 2008522176 A JP2008522176 A JP 2008522176A JP 2008522176 A JP2008522176 A JP 2008522176A JP 2009505953 A JP2009505953 A JP 2009505953A
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Japan
Prior art keywords
benzoquinone
undecyl
bis
group
compound
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JP2008522176A
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English (en)
Japanese (ja)
Inventor
シャクティー ウパダヤイ，
ラマン ヤダヴ，
ヴィジャイ ガンガン，
ヨーゲシュ カネカー，
Original Assignee
リライアンス ライフ サイエンシーズ プライベイト リミテッド
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Publication of JP2009505953A publication Critical patent/JP2009505953A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C07C50/04—Benzoquinones, i.e. C6H4O2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
JP2008522176A 2005-07-21 2005-09-19 リパーゼに媒介される疾患の処置のための化合物 Pending JP2009505953A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN864MU2005 2005-07-21
PCT/IN2005/000318 WO2007010546A1 (en) 2005-07-21 2005-09-19 Compounds for treatment of lipase-mediated diseases

Publications (1)

Publication Number Publication Date
JP2009505953A true JP2009505953A (ja) 2009-02-12

Family

ID=36121552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008522176A Pending JP2009505953A (ja) 2005-07-21 2005-09-19 リパーゼに媒介される疾患の処置のための化合物

Country Status (12)

Country Link
EP (1) EP1937622A1 (ru)
JP (1) JP2009505953A (ru)
KR (1) KR100928954B1 (ru)
CN (1) CN101228108A (ru)
AU (1) AU2005334672A1 (ru)
BR (1) BRPI0520515A2 (ru)
CA (1) CA2614585A1 (ru)
IL (1) IL188894A0 (ru)
NZ (1) NZ565878A (ru)
RU (1) RU2420513C2 (ru)
WO (1) WO2007010546A1 (ru)
ZA (1) ZA200800567B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
SG11201507105RA (en) * 2013-03-14 2015-10-29 Shionogi & Co Monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase
EP3055289A4 (en) * 2013-10-08 2017-03-15 Temple University Of The Commonwealth System Of Higher Education Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition
US10259804B2 (en) 2014-09-26 2019-04-16 Shifa Biomedical Corporation Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7510536A (en) * 1975-09-05 1977-03-08 Council Scient Ind Res Salts of embelin with primary amines
DE2540282A1 (de) * 1975-09-10 1977-03-24 Council Scient Ind Res Kondensationsprodukt von embelin mit einem primaeren amin und verfahren zu seiner herstellung
JP2003532634A (ja) * 1999-12-30 2003-11-05 プロテオテック・インコーポレイテッド アミロイド症およびα−シヌクレイン線維疾患の処置用ポリヒドロキシル化芳香族化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7510536A (en) * 1975-09-05 1977-03-08 Council Scient Ind Res Salts of embelin with primary amines
DE2540282A1 (de) * 1975-09-10 1977-03-24 Council Scient Ind Res Kondensationsprodukt von embelin mit einem primaeren amin und verfahren zu seiner herstellung
JP2003532634A (ja) * 1999-12-30 2003-11-05 プロテオテック・インコーポレイテッド アミロイド症およびα−シヌクレイン線維疾患の処置用ポリヒドロキシル化芳香族化合物

Also Published As

Publication number Publication date
ZA200800567B (en) 2008-11-26
AU2005334672A1 (en) 2007-01-25
CN101228108A (zh) 2008-07-23
RU2420513C2 (ru) 2011-06-10
BRPI0520515A2 (pt) 2009-05-12
RU2008106628A (ru) 2009-08-27
NZ565878A (en) 2010-04-30
KR100928954B1 (ko) 2009-11-30
CA2614585A1 (en) 2007-01-25
EP1937622A1 (en) 2008-07-02
IL188894A0 (en) 2008-04-13
WO2007010546A1 (en) 2007-01-25
KR20080030044A (ko) 2008-04-03

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