JP2009502965A5 - - Google Patents

Info

Publication number

JP2009502965A5

JP2009502965A5 JP2008524245A JP2008524245A JP2009502965A5 JP 2009502965 A5 JP2009502965 A5 JP 2009502965A5 JP 2008524245 A JP2008524245 A JP 2008524245A JP 2008524245 A JP2008524245 A JP 2008524245A JP 2009502965 A5 JP2009502965 A5 JP 2009502965A5

Authority

JP

Japan

Prior art keywords

shows

mupirocin

nisin

treatment

aureus

Prior art date

2006-07-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010053775 Nisin Proteins 0.000 description 9
• NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 9
• DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 description 9
• 239000004309 nisin Substances 0.000 description 9
• 235000010297 nisin Nutrition 0.000 description 9
• MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 8
• 229960003128 mupirocin Drugs 0.000 description 8
• 229930187697 mupirocin Natural products 0.000 description 8
• 206010052428 Wound Diseases 0.000 description 6
• 208000027418 Wounds and injury Diseases 0.000 description 6
• 108010001478 Bacitracin Proteins 0.000 description 4
• 229960003071 bacitracin Drugs 0.000 description 4
• 229930184125 bacitracin Natural products 0.000 description 4
• CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 230000000694 effects Effects 0.000 description 4
• 208000015181 infectious disease Diseases 0.000 description 4
• 239000000203 mixture Substances 0.000 description 3
• 241000894006 Bacteria Species 0.000 description 2
• 206010041925 Staphylococcal infections Diseases 0.000 description 2
• 241000191967 Staphylococcus aureus Species 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
• 229930182566 Gentamicin Natural products 0.000 description 1
• 108090000988 Lysostaphin Proteins 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 230000001332 colony forming effect Effects 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 238000013401 experimental design Methods 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 229960002518 gentamicin Drugs 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 206010040872 skin infection Diseases 0.000 description 1
• 208000015339 staphylococcus aureus infection Diseases 0.000 description 1