JP2009501533A5 - - Google Patents
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- Publication number
- JP2009501533A5 JP2009501533A5 JP2008521742A JP2008521742A JP2009501533A5 JP 2009501533 A5 JP2009501533 A5 JP 2009501533A5 JP 2008521742 A JP2008521742 A JP 2008521742A JP 2008521742 A JP2008521742 A JP 2008521742A JP 2009501533 A5 JP2009501533 A5 JP 2009501533A5
- Authority
- JP
- Japan
- Prior art keywords
- oocyte
- bmp
- activity
- medium
- modulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000287 oocyte Anatomy 0.000 claims 65
- 238000000034 method Methods 0.000 claims 37
- 230000000694 effects Effects 0.000 claims 31
- 239000002609 medium Substances 0.000 claims 29
- 230000019491 signal transduction Effects 0.000 claims 22
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims 20
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims 20
- 230000001419 dependent effect Effects 0.000 claims 20
- 102000003928 Bone morphogenetic protein 15 Human genes 0.000 claims 19
- 108090000349 Bone morphogenetic protein 15 Proteins 0.000 claims 19
- 210000001771 cumulus cell Anatomy 0.000 claims 18
- 210000001161 mammalian embryo Anatomy 0.000 claims 17
- 102000004858 Growth differentiation factor-9 Human genes 0.000 claims 15
- 108090001086 Growth differentiation factor-9 Proteins 0.000 claims 15
- 210000002503 granulosa cell Anatomy 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 230000035800 maturation Effects 0.000 claims 10
- 230000001105 regulatory effect Effects 0.000 claims 7
- 230000006907 apoptotic process Effects 0.000 claims 6
- 210000002257 embryonic structure Anatomy 0.000 claims 4
- 230000003325 follicular Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000013066 combination product Substances 0.000 claims 2
- 229940127555 combination product Drugs 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 230000013020 embryo development Effects 0.000 claims 2
- 230000004720 fertilization Effects 0.000 claims 2
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000002394 ovarian follicle Anatomy 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 230000002424 anti-apoptotic effect Effects 0.000 claims 1
- 230000018109 developmental process Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000013361 fetuin Human genes 0.000 claims 1
- 108060002885 fetuin Proteins 0.000 claims 1
- 210000001733 follicular fluid Anatomy 0.000 claims 1
- -1 follicular fluid Proteins 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2005903782A AU2005903782A0 (en) | 2005-07-18 | Modulation of granulosa cell apoptosis | |
| PCT/AU2006/001002 WO2007009166A1 (en) | 2005-07-18 | 2006-07-18 | Modulation of granulosa cell apoptosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141544A Division JP5841973B2 (ja) | 2005-07-18 | 2013-07-05 | 顆粒膜細胞アポトーシスの調節 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009501533A JP2009501533A (ja) | 2009-01-22 |
| JP2009501533A5 true JP2009501533A5 (https=) | 2009-09-03 |
Family
ID=37668339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008521742A Pending JP2009501533A (ja) | 2005-07-18 | 2006-07-18 | 顆粒膜細胞アポトーシスの調節 |
| JP2013141544A Expired - Fee Related JP5841973B2 (ja) | 2005-07-18 | 2013-07-05 | 顆粒膜細胞アポトーシスの調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141544A Expired - Fee Related JP5841973B2 (ja) | 2005-07-18 | 2013-07-05 | 顆粒膜細胞アポトーシスの調節 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8530235B2 (https=) |
| EP (2) | EP2228070B1 (https=) |
| JP (2) | JP2009501533A (https=) |
| KR (1) | KR101502110B1 (https=) |
| CN (1) | CN101272804A (https=) |
| CA (1) | CA2615006A1 (https=) |
| DK (1) | DK2228070T3 (https=) |
| WO (1) | WO2007009166A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014018404A1 (en) * | 2012-07-21 | 2014-01-30 | Baylor College Of Medicine | Gdf9:bmp15 heterodimers for enhancing fertility |
| CN105916977A (zh) * | 2013-10-07 | 2016-08-31 | 东北大学 | 用于使用自体细胞系统从生殖系细胞离体产生有发育能力的卵的方法和组合物 |
| CA2943037C (en) | 2014-03-27 | 2021-07-27 | Northeastern University | Methods for growth and maturation of ovarian follicles |
| AU2018214444A1 (en) * | 2017-02-01 | 2019-09-19 | Anlagen Pty Ltd | Gamete-secreted growth factors |
| EP3790894B1 (en) | 2018-05-09 | 2024-10-23 | Monash University | Modified gdf9 polypeptide monomer and method of promoting proliferation and differentiation of granulosa cells and oocyte maturation |
| CN116814685B (zh) * | 2023-06-05 | 2025-05-06 | 华南农业大学 | Zfp42基因在猪卵巢颗粒细胞中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6030617A (en) * | 1993-01-12 | 2000-02-29 | The Johns Hopkins University School Of Medicine | Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation |
| CA2153653C (en) * | 1993-01-12 | 2010-12-07 | Se-Jin Lee | Growth differentiation factor-9 |
| EP1066528A1 (en) * | 1998-04-01 | 2001-01-10 | Baylor College Of Medicine | Assay for growth differentiation factor 9 |
| CA2353085A1 (en) * | 1998-12-01 | 2000-06-08 | Akzo Nobel N.V. | Improvement of folliculogenesis |
| NZ502796A (en) * | 2000-06-15 | 2003-02-28 | Agres Ltd | Nucleotide and amino acid sequences of oocyte factors related to GDF-9B or GDF-9 |
| FR2812004B1 (fr) * | 2000-07-24 | 2002-12-27 | Ccd Lab | Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
| WO2005097978A1 (en) * | 2004-04-06 | 2005-10-20 | Adelaide Research & Innovation Pty Ltd | Modulation of granulosa cell proliferation and differentiation |
| CA2589898A1 (en) * | 2004-12-02 | 2006-06-08 | Agresearch Limited | Modulation of ovulation |
-
2006
- 2006-07-18 CA CA002615006A patent/CA2615006A1/en not_active Abandoned
- 2006-07-18 JP JP2008521742A patent/JP2009501533A/ja active Pending
- 2006-07-18 DK DK10004342.1T patent/DK2228070T3/da active
- 2006-07-18 EP EP10004342.1A patent/EP2228070B1/en not_active Not-in-force
- 2006-07-18 US US11/988,949 patent/US8530235B2/en not_active Expired - Fee Related
- 2006-07-18 EP EP06760864A patent/EP1909820A4/en not_active Withdrawn
- 2006-07-18 KR KR1020087003867A patent/KR101502110B1/ko not_active Expired - Fee Related
- 2006-07-18 WO PCT/AU2006/001002 patent/WO2007009166A1/en not_active Ceased
- 2006-07-18 CN CNA2006800343274A patent/CN101272804A/zh active Pending
-
2013
- 2013-07-05 JP JP2013141544A patent/JP5841973B2/ja not_active Expired - Fee Related
- 2013-08-15 US US13/968,359 patent/US20140073052A1/en not_active Abandoned
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