CA2615006A1 - Modulation of granulosa cell apoptosis - Google Patents

Modulation of granulosa cell apoptosis Download PDF

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Publication number
CA2615006A1
CA2615006A1 CA002615006A CA2615006A CA2615006A1 CA 2615006 A1 CA2615006 A1 CA 2615006A1 CA 002615006 A CA002615006 A CA 002615006A CA 2615006 A CA2615006 A CA 2615006A CA 2615006 A1 CA2615006 A1 CA 2615006A1
Authority
CA
Canada
Prior art keywords
bmp
oocyte
activity
modulating
signalling pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002615006A
Other languages
English (en)
French (fr)
Inventor
Robert Bruce Gilchrist
Jeremy Thompson
Tamer Hussein
Original Assignee
Adelaide Research and Innovation Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2005903782A external-priority patent/AU2005903782A0/en
Application filed by Adelaide Research and Innovation Pty Ltd filed Critical Adelaide Research and Innovation Pty Ltd
Publication of CA2615006A1 publication Critical patent/CA2615006A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0609—Oocytes, oogonia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/04—Coculture with; Conditioned medium produced by germ cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002615006A 2005-07-18 2006-07-18 Modulation of granulosa cell apoptosis Abandoned CA2615006A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2005903782 2005-07-18
AU2005903782A AU2005903782A0 (en) 2005-07-18 Modulation of granulosa cell apoptosis
PCT/AU2006/001002 WO2007009166A1 (en) 2005-07-18 2006-07-18 Modulation of granulosa cell apoptosis

Publications (1)

Publication Number Publication Date
CA2615006A1 true CA2615006A1 (en) 2007-01-25

Family

ID=37668339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002615006A Abandoned CA2615006A1 (en) 2005-07-18 2006-07-18 Modulation of granulosa cell apoptosis

Country Status (8)

Country Link
US (2) US8530235B2 (https=)
EP (2) EP2228070B1 (https=)
JP (2) JP2009501533A (https=)
KR (1) KR101502110B1 (https=)
CN (1) CN101272804A (https=)
CA (1) CA2615006A1 (https=)
DK (1) DK2228070T3 (https=)
WO (1) WO2007009166A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014018404A1 (en) * 2012-07-21 2014-01-30 Baylor College Of Medicine Gdf9:bmp15 heterodimers for enhancing fertility
US20160237402A1 (en) * 2013-10-07 2016-08-18 Northeastern University Methods and Compositions for Ex Vivo Generation of Developmentally Competent Eggs from Germ Line Cells Using Autologous Cell Systems
EP3122366A4 (en) 2014-03-27 2017-11-15 Jonathan Lee Tilly Methods for growth and maturation of ovarian follicles
EP3577457A4 (en) * 2017-02-01 2021-01-20 Robert Bruce Gilchrist GROWTH FACTORS SECRETED BY GAMETES
CN112601756A (zh) 2018-05-09 2021-04-02 莫拿什大学 用于增强生育力的剂和方法
CN116814685B (zh) * 2023-06-05 2025-05-06 华南农业大学 Zfp42基因在猪卵巢颗粒细胞中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0678101A4 (en) 1993-01-12 1997-07-16 Univ Johns Hopkins Med FACTOR-9 OF GROWTH AND DIFFERENTIATION.
US6030617A (en) * 1993-01-12 2000-02-29 The Johns Hopkins University School Of Medicine Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation
AU753793B2 (en) * 1998-04-01 2002-10-31 Baylor College Of Medicine Assay for growth differentiation factor 9
DE69907725T2 (de) * 1998-12-01 2004-03-18 Akzo Nobel N.V. Verbesserung der follikelgenese
NZ502796A (en) * 2000-06-15 2003-02-28 Agres Ltd Nucleotide and amino acid sequences of oocyte factors related to GDF-9B or GDF-9
FR2812004B1 (fr) * 2000-07-24 2002-12-27 Ccd Lab Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons
WO2005097978A1 (en) * 2004-04-06 2005-10-20 Adelaide Research & Innovation Pty Ltd Modulation of granulosa cell proliferation and differentiation
JP2008521891A (ja) * 2004-12-02 2008-06-26 アグリサーチ・リミテッド 排卵の調節

Also Published As

Publication number Publication date
DK2228070T3 (da) 2017-01-02
EP1909820A4 (en) 2009-08-12
WO2007009166A1 (en) 2007-01-25
CN101272804A (zh) 2008-09-24
US20140073052A1 (en) 2014-03-13
EP2228070A3 (en) 2010-12-29
EP2228070A2 (en) 2010-09-15
JP5841973B2 (ja) 2016-01-13
US20080274963A1 (en) 2008-11-06
EP2228070B1 (en) 2016-09-07
KR101502110B1 (ko) 2015-03-12
KR20080043783A (ko) 2008-05-19
EP1909820A1 (en) 2008-04-16
JP2009501533A (ja) 2009-01-22
JP2013215207A (ja) 2013-10-24
US8530235B2 (en) 2013-09-10

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20180718