JP2009292791A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009292791A5 JP2009292791A5 JP2008150205A JP2008150205A JP2009292791A5 JP 2009292791 A5 JP2009292791 A5 JP 2009292791A5 JP 2008150205 A JP2008150205 A JP 2008150205A JP 2008150205 A JP2008150205 A JP 2008150205A JP 2009292791 A5 JP2009292791 A5 JP 2009292791A5
- Authority
- JP
- Japan
- Prior art keywords
- powder
- external preparation
- skin
- oil
- silicone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 claims description 90
- -1 vinyl dimethicone Chemical compound 0.000 claims description 40
- 210000003491 Skin Anatomy 0.000 claims description 33
- 229920001296 polysiloxane Polymers 0.000 claims description 33
- 239000002537 cosmetic Substances 0.000 claims description 27
- 238000002360 preparation method Methods 0.000 claims description 26
- JEIPFZHSYJVQDO-UHFFFAOYSA-N Iron(III) oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 16
- 239000011247 coating layer Substances 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 6
- 229910000460 iron oxide Inorganic materials 0.000 claims description 6
- 210000001772 Blood Platelets Anatomy 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229940008099 dimethicone Drugs 0.000 claims description 3
- 229920002050 silicone resin Polymers 0.000 claims description 3
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- 239000004945 silicone rubber Substances 0.000 claims description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 239000003860 topical agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 16
- 239000003921 oil Substances 0.000 description 16
- 235000019198 oils Nutrition 0.000 description 16
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 14
- 239000010410 layer Substances 0.000 description 13
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 239000004359 castor oil Substances 0.000 description 7
- 235000019438 castor oil Nutrition 0.000 description 7
- 229940015001 Glycerin Drugs 0.000 description 6
- 239000006096 absorbing agent Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 229960005150 glycerol Drugs 0.000 description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Trimethylglycine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000010445 mica Substances 0.000 description 5
- 229910052618 mica group Inorganic materials 0.000 description 5
- 239000004166 Lanolin Substances 0.000 description 4
- 229940039717 Lanolin Drugs 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 230000003287 optical Effects 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 229910052719 titanium Inorganic materials 0.000 description 4
- 229920002907 Guar gum Polymers 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N TiO Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 235000010417 guar gum Nutrition 0.000 description 3
- 239000000665 guar gum Substances 0.000 description 3
- 229960002154 guar gum Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 229910001929 titanium oxide Inorganic materials 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-M 16-methylheptadecanoate Chemical class CC(C)CCCCCCCCCCCCCCC([O-])=O XDOFQFKRPWOURC-UHFFFAOYSA-M 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N AI2O3 Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L Barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 2
- 229960003563 Calcium Carbonate Drugs 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- 229940009714 Erythritol Drugs 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N Erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N Lauric acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L Magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N Palmitic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene (PE) Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229960004063 Propylene glycol Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 2
- 229930003779 Vitamin B12 Natural products 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000010426 asphalt Substances 0.000 description 2
- 150000001622 bismuth compounds Chemical class 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 125000003346 cobalamin group Chemical group 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- QUEDXNHFTDJVIY-WENCSYSZSA-N gamma-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@](CCC[C@@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-WENCSYSZSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 239000011776 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 230000003020 moisturizing Effects 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4H-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 235000019163 vitamin B12 Nutrition 0.000 description 2
- 239000011715 vitamin B12 Substances 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- WJJZURXPOSMHKT-MNDPQUGUSA-N (1Z)-1-[(2-chloro-4-nitrophenyl)hydrazinylidene]naphthalen-2-one Chemical compound ClC1=CC([N+](=O)[O-])=CC=C1N\N=C/1C2=CC=CC=C2C=CC\1=O WJJZURXPOSMHKT-MNDPQUGUSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol;(Z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2R,3R,4S,5R,6S)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4S,5R,6R)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- HYRUXGRHTJRKNG-SMBWEDIMSA-N (2S,3R,4R,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound O[C@@H]1[C@@H](O)[C@H](OC)O[C@H](CO)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](OC)[C@@H](CO)O2)O)[C@@H](CO)O1 HYRUXGRHTJRKNG-SMBWEDIMSA-N 0.000 description 1
- WKPUACLQLIIVJJ-RHKLHVFKSA-M (2S,3R,4R,5S,6R)-4-hydroxy-3-methoxy-6-[(2S,3R,4S,5S,6R)-6-methoxy-4-oxido-5-(sulfooxyamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-5-sulfooxyoxane-2-carboxylate Chemical compound [O-][C@H]1[C@H](NOS(O)(=O)=O)[C@H](OC)O[C@@H](COS(O)(=O)=O)[C@@H]1O[C@H]1[C@@H](OS(O)(=O)=O)[C@H](O)[C@@H](OC)[C@@H](C([O-])=O)O1 WKPUACLQLIIVJJ-RHKLHVFKSA-M 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N 1-Tetradecanol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 1
- VUQPJRPDRDVQMN-UHFFFAOYSA-N 1-chlorooctadecane Chemical compound CCCCCCCCCCCCCCCCCCCl VUQPJRPDRDVQMN-UHFFFAOYSA-N 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N 2,2-dimethylpropane-1,3-diol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- IYAZLDLPUNDVAG-UHFFFAOYSA-N 2-(benzotriazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(O)C(N2N=C3C=CC=CC3=N2)=C1 IYAZLDLPUNDVAG-UHFFFAOYSA-N 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N 2-Imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 description 1
- GNCOVOVCHIHPHP-UHFFFAOYSA-N 2-[[4-[4-[(1-anilino-1,3-dioxobutan-2-yl)diazenyl]-3-chlorophenyl]-2-chlorophenyl]diazenyl]-3-oxo-N-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC(C(=C1)Cl)=CC=C1C(C=C1Cl)=CC=C1N=NC(C(C)=O)C(=O)NC1=CC=CC=C1 GNCOVOVCHIHPHP-UHFFFAOYSA-N 0.000 description 1
- NCLNAHJFXIKYBY-UHFFFAOYSA-N 2-hexyldecyl 16-methylheptadecanoate Chemical compound CCCCCCCCC(CCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C NCLNAHJFXIKYBY-UHFFFAOYSA-N 0.000 description 1
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-hydroxypropyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N 2-methyl-2-propenoic acid methyl ester Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- DQAKJEWZWDQURW-UHFFFAOYSA-N 2-oxopyrrolidine-1-carboxylic acid Chemical compound OC(=O)N1CCCC1=O DQAKJEWZWDQURW-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N 3-(2,3-dihydroxypropoxy)propane-1,2-diol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-Aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N Aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N Anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 229960000686 Benzalkonium Chloride Drugs 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N Benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- GLQBXSIPUULYOG-UHFFFAOYSA-M Bismuth oxychloride Chemical compound Cl[Bi]=O GLQBXSIPUULYOG-UHFFFAOYSA-M 0.000 description 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N Bute hydrocarbon Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
- JHLNERQLKQQLRZ-UHFFFAOYSA-N Calcium silicate Chemical compound [Ca+2].[Ca+2].[O-][Si]([O-])([O-])[O-] JHLNERQLKQQLRZ-UHFFFAOYSA-N 0.000 description 1
- 229940073532 Candelilla Wax Drugs 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229940113118 Carrageenan Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- DJHJJVWPFGHIPH-OODMECLYSA-N Chitin Chemical compound O[C@@H]1C(NC(=O)C)[C@H](O)OC(CO)[C@H]1COC[C@H]1C(NC(C)=O)[C@@H](O)[C@H](COC[C@H]2C([C@@H](O)[C@H](O)C(CO)O2)NC(C)=O)C(CO)O1 DJHJJVWPFGHIPH-OODMECLYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N Chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N Chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- LBFUKZWYPLNNJC-UHFFFAOYSA-N Cobalt(II,III) oxide Chemical compound [Co]=O.O=[Co]O[Co]=O LBFUKZWYPLNNJC-UHFFFAOYSA-N 0.000 description 1
- 239000001879 Curdlan Substances 0.000 description 1
- 229920002558 Curdlan Polymers 0.000 description 1
- 240000000590 Cydonia oblonga Species 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-α-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 229940105990 DIGLYCERIN Drugs 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L Dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical compound CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 1
- VJHINFRRDQUWOJ-UHFFFAOYSA-N Dioctyl sebacate Chemical compound CCCCC(CC)COC(=O)CCCCCCCCC(=O)OCC(CC)CCCC VJHINFRRDQUWOJ-UHFFFAOYSA-N 0.000 description 1
- 229940113120 Dipropylene Glycol Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N Dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- NOPFSRXAKWQILS-UHFFFAOYSA-N Docosanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 1
- 229940096919 Glycogen Drugs 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- BYSGBSNPRWKUQH-UJDJLXLFSA-N Glycogen Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)O1 BYSGBSNPRWKUQH-UJDJLXLFSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N Hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N Hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N Keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 229920000288 Keratan sulfate Polymers 0.000 description 1
- 229960000448 Lactic acid Drugs 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 210000000088 Lip Anatomy 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N Malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N Maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- LUEWUZLMQUOBSB-GFVSVBBRSA-N Mannan Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-GFVSVBBRSA-N 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- 229940117969 NEOPENTYL GLYCOL Drugs 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 229940116985 POTASSIUM LAURYL SULFATE Drugs 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- ZQTHOIGMSJMBLM-BUJSFMDZSA-N Pangamic acid Chemical compound CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O ZQTHOIGMSJMBLM-BUJSFMDZSA-N 0.000 description 1
- 229940055726 Pantothenic Acid Drugs 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229940066842 Petrolatum Drugs 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M Potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940079889 Pyrrolidonecarboxylic Acid Drugs 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229960002477 Riboflavin Drugs 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 229940043230 Sarcosine Drugs 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N Silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N Simethicone Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 229940083542 Sodium Drugs 0.000 description 1
- 229940010747 Sodium Hyaluronate Drugs 0.000 description 1
- 229940005581 Sodium Lactate Drugs 0.000 description 1
- 229940045870 Sodium Palmitate Drugs 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- NGSFWBMYFKHRBD-UHFFFAOYSA-M Sodium lactate Chemical compound [Na+].CC(O)C([O-])=O NGSFWBMYFKHRBD-UHFFFAOYSA-M 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M Sodium laurate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940082004 Sodium laurate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M Sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229940091252 Sodium supplements Drugs 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N Sorbitan Chemical compound OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 229960005078 Sorbitan sesquioleate Drugs 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N Squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N Stearyl alcohol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- FKHIFSZMMVMEQY-UHFFFAOYSA-N Talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N Tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Tris Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- HWKQNAWCHQMZHK-UHFFFAOYSA-N Trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N Undecylenic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- 229940029983 VITAMINS Drugs 0.000 description 1
- 229940045997 Vitamin A Drugs 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229940011671 Vitamin B6 Drugs 0.000 description 1
- 229930003629 Vitamin B6 Natural products 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- 229940046008 Vitamin D Drugs 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- 229940046009 Vitamin E Drugs 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N Xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 Xylitol Drugs 0.000 description 1
- NWGKJDSIEKMTRX-HSACVWGTSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (E)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-HSACVWGTSA-N 0.000 description 1
- UDRYFKCHZFVZGJ-UHFFFAOYSA-N [5-hexadecanoyloxy-4-(hexadecanoyloxymethyl)-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(OC(=O)CCCCCCCCCCCCCCC)=C1COC(=O)CCCCCCCCCCCCCCC UDRYFKCHZFVZGJ-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229940087168 alpha Tocopherol Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- 229960001452 alpha-Tocopherol Acetate Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 229940066595 beta tocopherol Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 1
- 229940073609 bismuth oxychloride Drugs 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- DBZJJPROPLPMSN-UHFFFAOYSA-N bromoeosin Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C(O)C(Br)=C1OC1=C(Br)C(O)=C(Br)C=C21 DBZJJPROPLPMSN-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229910000428 cobalt oxide Inorganic materials 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000019316 curdlan Nutrition 0.000 description 1
- 229940078035 curdlan Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- HZYOIDDAGQUYLF-AXHWYJOWSA-L disodium;(3E)-5-amino-4-oxo-3-(phenylhydrazinylidene)naphthalene-2,7-disulfonate Chemical compound [Na+].[Na+].O=C1C=2C(N)=CC(S([O-])(=O)=O)=CC=2C=C(S([O-])(=O)=O)\C1=N\NC1=CC=CC=C1 HZYOIDDAGQUYLF-AXHWYJOWSA-L 0.000 description 1
- OOYIOIOOWUGAHD-UHFFFAOYSA-L disodium;2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate Chemical compound [Na+].[Na+].O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(Br)=C([O-])C(Br)=C1OC1=C(Br)C([O-])=C(Br)C=C21 OOYIOIOOWUGAHD-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229950008690 docosanoic acid Drugs 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- CNNPNFVEEMWBBH-UHFFFAOYSA-N dodecyl(oxido)azanium Chemical compound CCCCCCCCCCCC[NH2]=O CNNPNFVEEMWBBH-UHFFFAOYSA-N 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- WUKXMJCZWYUIRZ-UHFFFAOYSA-N hexadecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(C)O WUKXMJCZWYUIRZ-UHFFFAOYSA-N 0.000 description 1
- OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- TXGJTWACJNYNOJ-UHFFFAOYSA-N hexane-2,4-diol Chemical compound CCC(O)CC(C)O TXGJTWACJNYNOJ-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 description 1
- 229960000903 pantethine Drugs 0.000 description 1
- 235000008975 pantethine Nutrition 0.000 description 1
- 239000011581 pantethine Substances 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N pantothenic acid Natural products OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001888 polyacrylic acid Polymers 0.000 description 1
- 230000000379 polymerizing Effects 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N rac-1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- SXQCTESRRZBPHJ-UHFFFAOYSA-M sodium;4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzene-1,3-disulfonate Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-M stearate Chemical class CCCCCCCCCCCCCCCCCC([O-])=O QIQXTHQIDYTFRH-UHFFFAOYSA-M 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 230000001052 transient Effects 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-O trimethylammonium Chemical compound C[NH+](C)C GETQZCLCWQTVFV-UHFFFAOYSA-O 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 229930003231 vitamins Natural products 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
Description
本発明は皮膚外用剤に関し、更に詳細にはメークアップ化粧料に好適な皮膚外用剤に関する。 The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for makeup cosmetics.
化粧料などの皮膚外用剤に於いて、粉体には様々な機能が存し、その様な機能を担って皮膚外用剤に配合されている。その機能としては、例えば、光学的効果により、シミやくすみ等を隠蔽したり、顔色を明るく見せて、印象形成を好適に変化させることなどが例示できる。特にメークアップ化粧料はこの様な粉体の光学的効果をその中心に据えた化粧料である。即ち、メークアップ化粧料は、ポイントメークによる目周辺の強調、口唇の潤い感といった効果の他、肌のシミやくすみといった美観を損なうトラブルをファンデーションに代表されるベースメークアップによって改善する機能を有する。この様な光学効果において、従前は隠蔽性に依存するところが大きく、例えば、肌のトラブルは酸化チタンなどの隠蔽性の高い粉体を含有するファンデーションにより改善する方法がとられてきたが、近年、この様な隠蔽性に依存すると、不自然な仕上がりになりやすく、自然な仕上がり効果も要求品質に加えられるようになってきている。 In the external preparation for skin such as cosmetics, the powder resides various functions, are blended in the skin external agent plays a such a function of it. Examples of the function include concealing spots and dullness due to an optical effect, making the face color brighter, and suitably changing impression formation. In particular, makeup cosmetics are cosmetics with the optical effect of such powders at the center. In other words, makeup cosmetics have the effect of improving problems such as skin spots and dullness with base makeup represented by foundations, as well as effects such as emphasis around the eyes and moisturizing lips by point makeup. . In such an optical effect, the place which depends on concealment is large in the past, for example, a method of improving skin trouble with a foundation containing powder with high concealment such as titanium oxide has been taken in recent years. Relying on such concealment tends to produce an unnatural finish, and a natural finish effect has been added to the required quality.
そこで、肌トラブルを充分カバーしながら自然な仕上がりを有するファンデーションとして、鮮やかな緑色に調色したベースメークアップ化粧料が検討されている（例えば、特許文献１参照）。また、透明感のある自然な仕上がり効果を持たす方法として、特定のルチル型酸化チタンを配合した化粧料の効果が報告されており、該発明により皮膚に塗布した際に青白みが少なく、透明感のある自然な仕上がりを与え、更に２８０ｎｍ〜４００ｎｍの波長域の紫外線に対して遮蔽効果を持ち、更に使用性が良好であり、化粧崩れが起こるまでの時間が従来より長い化粧料を提供できることも報告されている（例えば、特許文献２参照）。更に、酸化鉄とビスマス化合物の複合顔料、具体的にはビスマス化合物表面に酸化鉄を被覆した粉体を含有する化粧料により、素肌感と透明感のある自然な仕上がりを与えることのできる顔料及び化粧料を提供できることも報告されている（例えば、特許文献３参照）。特に、近年注目されている自然な仕上がりのメークアップ化粧料は、隠蔽性粉体や板状粉体に半透明層を設けたものが例示できる（例えば、特許文献４、特許文献５を参照）。この様な技術において残されている課題としては、化粧効果の維持性の向上と、化粧料の均一な塗布性が挙げられる。特に、均一塗布性は、再現性の良い化粧効果そのものの発現に係わる重要な課題であると言える。 Therefore, as a full Andeshon that have a natural finish while fully cover the skin trouble, base makeup cosmetics that toning in vivid green has been studied (for example, see Patent Document 1). In addition, as a method of giving a natural finish effect with transparency, the effect of a cosmetic compounded with a specific rutile type titanium oxide has been reported. It gives a natural finish with, further to have a shielding effect to ultraviolet rays in the wavelength range of 280 nm to 400 nm, a further use of good, that the time until the makeup occurs can provide longer than conventional cosmetics Has also been reported (see, for example, Patent Document 2). Further, the composite pigments of iron oxide and bismuth compounds, pigments in particular by cosmetics containing a powder coated with iron oxide on the surface of bismuth compounds, capable of providing natural finish with a bare skin appearance and clarity It is also reported that cosmetics can be provided (see, for example, Patent Document 3). In particular, the natural finish makeup cosmetics that have been attracting attention in recent years can be exemplified by those having a translucent layer provided on a concealable powder or plate-like powder (see, for example, Patent Document 4 and Patent Document 5). . Problems remaining in such a technique include improvement in the maintenance of the makeup effect and uniform applicability of the cosmetic. In particular, it can be said that the uniform coating property is an important issue related to the expression of the cosmetic effect itself with good reproducibility.
一方、隠蔽力の高いベースメークアップ化粧料において、自然な仕上がりに加えて、延展性が悪いことにより、刺激感や使用感が悪いという課題があった。そこで、リンゴ酸ジイソステアリル、ジペンタエリトリットモノステアリン酸エステル、ショ糖テトライソステアレート、重質流動イソパラフィン、高粘度シリコーン及びポリグリセリンのイソステアリン酸エステル等の高粘度油剤と、ラウロイルサルコシンイソプロピルの様な（Ｃ１０〜２０）アシルサルコシン（Ｃ１〜４）アルキルとを含有させることで、密着性とともに延展性にも優れる化粧料を提供できることが報告されている（例えば、特許文献６参照）。又、油剤には不溶の球状のシリコーン粉体であるシリコーンエラストマーを添加することにより、化粧料の延展性が改善する報告も存する（例えば特許文献７を参照）。 On the other hand, in the base makeup cosmetics with high hiding power, there is a problem that in addition to a natural finish, the spreadability is poor, and thus the feeling of stimulation and the feeling of use are poor. Therefore, Li Ngosan diisostearyl, dipentaerythritol monostearate, sucrose tetraisostearate, heavy liquid isoparaffin, and a high viscosity oil isostearate esters of high viscosity silicone and polyglycerin, lauroyl sarcosine isopropyl It has been reported that cosmetics that are excellent in adhesion and spreadability can be provided by including (C10-20) acyl sarcosine (C1-4) alkyl as described above (see, for example, Patent Document 6). . Further, (see for example, Patent Document 7) by the addition of silicone elastomer, also exist reports spreadability of粧料improves a silicone powder spherical insoluble in oil.
しかしながら、１）半透明粉体を含有する被覆層を有する被覆板状粉体と、２）油剤には不溶の球状のシリコ−ン粉体とを含有する皮膚外用剤は全く知られておらず、この様な構成を採用することにより、自然な仕上がりであって、化粧効果の維持性と、均一塗布性に優れる化粧料が得られることも全く知られていなかった。 However, there is no known skin external preparation containing 1) a coated plate-like powder having a coating layer containing a translucent powder, and 2) a spherical silicone powder insoluble in the oil. It has not been known at all that by adopting such a configuration, it is possible to obtain a cosmetic that has a natural finish and maintains a cosmetic effect and is excellent in uniform application.
本発明は、この様な状況下為されたものであり、自然な仕上がりであって、化粧効果の維持性と、均一塗布性に優れる化粧料を提供することを課題とする。 The present invention has been made under such circumstances, and an object of the present invention is to provide a cosmetic that has a natural finish and is excellent in the maintenance of the makeup effect and the uniform application property.
この様な実状に鑑みて、本発明者は、自然な仕上がりであって、化粧効果の維持性と、均一塗布性に優れる化粧料を求めて、鋭意研究努力を重ねた結果、１）半透明粉体を含有する被覆層を有する被覆板状粉体と、２）油剤には不溶の球状のシリコーン粉体を含有する皮膚外用剤が、前記特性を有していることを見いだし、発明を完成させるにいたった。即ち、本発明は、以下に示すとおりである。
（１） １）半透明粉体を含有する被覆層を有する被覆板状粉体と、２）油剤には不溶の球状のシリコ−ン粉体とを含有することを特徴とする、皮膚外用剤。
（２） 前記半透明粉体が無水珪酸であることを特徴とする、（１）に記載の皮膚外用剤。
（３） 前記被覆板状粉体における被覆層に酸化鉄を含有することを特徴とする、（１）又は（２）に記載の皮膚外用剤。
（４） 前記油剤には不溶の球状のシリコーン粉体がシリコーンゴムとシリコーンレジンから成る粉体であることを特徴とする、（１）乃至（３）何れか１つに記載の皮膚外用剤。
（５） 前記油剤には不溶の球状のシリコーン粉体がビニルジメチコン／メチコン／シルセスキオキサンクロスポリマー、ジフェニルジメチコン／ビニルジフェニルジメチコン／シルセスキオキサンクロスポリマー、及びポリメチルシルセスキオキサンからなる群から選択される1種又は2種以上であることを特徴とする、（１）乃至（４）何れか１つに記載の皮膚外用剤。
（６）ベンガラ又はハイドロキシメチルポリシロキサン被覆ベンガラを含み、その含有量が皮膚外用剤全量に対して１質量％以下であることを特徴とする、（１）乃至（５）何れか１つに記載の皮膚外用剤。
（７）メークアップ化粧料であることを特徴とする、（１）乃至（６）何れか１つに記載の皮膚外用剤。
In view of such a situation, the present inventor has eagerly pursued research for cosmetics that have a natural finish and maintain makeup effect and are excellent in uniform application. 1) Translucent The invention has been completed by finding that a coated plate-like powder having a coating layer containing a powder and 2) an external preparation for skin containing a spherical silicone powder insoluble in an oil agent have the above-mentioned characteristics. I came to let you. That is, the present invention is as follows.
(1) An external preparation for skin, comprising: 1) a coated plate-like powder having a coating layer containing a translucent powder; and 2) a spherical silicone powder insoluble in the oil. .
(2) The skin external preparation according to (1), wherein the translucent powder is silicic anhydride.
(3), characterized by containing iron oxide in the coating layer in the coated platelet powder, skin external preparation as described in (1) or (2).
(4), characterized in that said oil agent silicone powder spherical insoluble are powder consisting of silicone rubber and silicone resin, (1) to (3) skin external preparation according to any one.
(5) A spherical silicone powder insoluble in the oil agent is composed of vinyl dimethicone / methicone / silsesquioxane crosspolymer, diphenyldimethicone / vinyldiphenyldimethicone / silsesquioxane crosspolymer, and polymethylsilsesquioxane. and characterized in that one or more members selected from the group, (1) to (4) skin external preparation according to any one.
(6) red iron oxide or include hydroxymethyl polysiloxane coating red iron oxide, and the content of that is not more than 1% by weight relative to the total amount of the skin treatment composition, either one (1) to (5) The skin external preparation described in 1.
(7) characterized in that it is a make-up cosmetics, (1) to (6) the skin external preparation according to any one.
本発明によれば、自然な仕上がりであって、化粧効果の維持性と、均一塗布性に優れる化粧料を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, it is a natural finish and can provide the cosmetics which are excellent in the maintenance of a makeup effect and uniform applicability | paintability.
＜１＞本発明の皮膚外用剤の必須成分である半透明粉体を含有する被覆層を有する被覆板状粉体
本発明の必須構成成分である半透明粉体を含有する被覆層を有する被覆板状粉体は、板状粉体の上層に、被覆している半透明粉体に起因する、半透明な性状を有する被覆層を有することを特徴とする。前記被覆層に含有される半透明粉体としては、屈折率１．４〜１．８の粉体が好適に例示でき、具体的には、シリカ（無水珪酸）、アルミナ、ジルコニア、炭酸カルシウム、炭酸マグネシウム、ケイ酸カルシウム、ケイ酸マグネシウム、メタクリル酸メチルポリマー、メチルシロキサン網状重合体、ナイロンパウダー等が好ましく例
示できる。かかる半透明粉体の平均粒径は２〜３０μｍが好ましい。これはこの範囲において自然に見える光学効果を好適に発現するためである。かかる被覆層には、その半透明性を損なわない範囲において、半透明粉体に分類されない粉体を含有することができる。この様な粉体としては、例えば、黄色酸化鉄、ベンガラ、紺青、群青、レーキ化されていても良い有機色素、該有機色素としては、赤色２０１号、赤色２０２号、赤色２０４号、赤色２０５号、赤色２２０号、赤色２２６号、赤色２２８号、赤色４０５号、橙色２０３号、橙色２０４号、黄色２０５号、黄色４０１号、青色４０４号、赤色３号、赤色１０４号、赤色１０６号、赤色２２７号、赤色２３０号、赤色４０１号、赤色５０５号、橙色２０５号、黄色４号、黄色５号、黄色２０２号、黄色２０３号、緑色３号、青色１号等が例示できる。特に好ましい形態は、半透明粉体に加えて、赤色の有色粉体と黄色の有色粉体とを含有する形態であり、赤色の有色粉体と黄色の有色粉体の割合は１：３〜１：１０であることが好ましい。有色粉体と半透明粉体は同一の層でただ一層とすることもできるし、半透明粉体層と有色色素とを含む層とが異なる層であっても良いし、半透明粉体層と半透明粉体と、有色粉体との複合化層の積層型でも良い。特に好ましいものは、有色色素と半透明粉体との複合体によって構成されている被覆層を中間層として有し、半透明粉体によって構成され色素を含有しない被覆層を最外層として有することを特徴とする、多層構造粉体である。前記板状粉体は、アスペクト比が１０〜９０の粉体であれば用いることができ、例えば、マイカ、セリサイト、チタンマイカ及びチタンセリサイト等から選ばれる１種又は２種以上が好ましく例示できる。特に、チタンセリサイトは、自然なツヤ感と、優れたカバー力を具現化することから、基体の粉体としては好ましい。前記最外層の表面は、シリコーン類、パーフルオロ基を有するカップリング剤、金属石鹸、アミノ酸誘導体により処理・改質されていてもよい。本発明の被覆板状粉体の被覆はメカノケミカル的でも、部分燒結によるものでも構わない。燒結条件としては、有酸素条件下或いは窒素気流下、１００〜１０００℃で焼成することが好ましく例示できるし、メカノケミカルな方法としては、遊星ボールミルによるコーティング方法が例示できる。この様な半透明粉体を含有する被覆層を有する被覆板状粉体には既に市販されているものが存し、それを利用することもできる。好ましい市販品としては、触媒化成社製の「ダーマリアルリーフN」が例示できる。本発明皮膚外用剤全量中に被覆板状粉体は０．００１〜４０質量％含有されることが好ましく、より好ましくは０．１〜２０質量％である。含有量が下限未満では自然な仕上がり効果が十分に発揮するのが難しい場合が存し、上限を超えると化粧品としての剤形の自由度が制限される場合が存する。
＜２＞油剤には不溶の球状のシリコーン粉体
本発明の必須構成成分である、油剤には不溶の球状のシリコーン粉体はシリコーンゴムとシリコーンレジンから成る粉体であることを特徴とする。本発明の油剤には不溶の球状のシリコーン粉体は、ビニルジメチコン／メチコン／シルセスキオキサンクロスポリマー、ジフェニルジメチコン／ビニルジフェニルジメチコン／シルセスキオキサンクロスポリマー、及びポリメチルシルセスキオキサンからなる群から選択される1種又は2種以上であり、かかる油剤に不溶の球状のシリコーン粉体は、（ポリ）メチル（ポリメトキシ）シロキサン、（ポリ）ビニル（ポリ）メチル（ポリ）メトキシシロキサン、メチルフェニル（ジ）メトキシシロキサンを脱アルコール縮合し、しかる後にビニル基を重合させて架橋を形成することにより製造することができるが、既に市販されているものを利用することも可能であり、好ましい市販品としてトスパールシリーズ（東芝シリコーン製）、ＫＳＰ−３００（信越化学社製）、ＫＳＰ−１００、１０１、１０２、１０３（信越化学社製）を例示することができる。本発明皮膚外用剤全量中に油剤には不溶の球状のシリコーン粉体は０．０１〜２０質量％含有されることが好ましく、より好ましくは０．１〜１０質量％である。配合量が下限未満では延展性良化効果が十分に発揮するのが難しい場合が存し、上限を超えると化粧品としての剤形の自由度が制限される場合が存する。
<1> Coated plate-like powder having a coating layer containing a translucent powder which is an essential component of the external preparation for skin of the present invention Coating having a coating layer containing a translucent powder which is an essential component of the present invention The plate-like powder is characterized by having a coating layer having a semi-transparent property due to the semi-transparent powder coated on the upper layer of the plate-like powder. As the translucent powder contained in the coating layer, a powder having a refractive index of 1.4 to 1.8 can be suitably exemplified. Specifically, silica (anhydrous silicic acid), alumina, zirconia, calcium carbonate, magnesium carbonate, calcium silicate, magnesium silicate, methyl methacrylate polymers, methylsiloxane reticular polymer, nylon powder Hitoshigayoshimi can Mashiku exemplified. The average particle size of such a translucent powder is preferably 2 to 30 μm. This is because an optical effect that looks natural in this range is suitably expressed. In such coating layer, in a range that does not impair its translucency, Ru can contain not classified translucent powder powder. Such powders include, for example, yellow iron oxide, bengara, bitumen, ultramarine blue, organic pigments that may be raked, and examples of the organic pigments include red 201, red 202, red 204, and red 205. No., Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Examples include Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, and the like. A particularly preferred form is a form containing a red colored powder and a yellow colored powder in addition to the translucent powder, and the ratio of the red colored powder to the yellow colored powder is 1: 3 to 3. It is preferably 1:10. It colored powder translucent powder Ru can also be a more just the same layer, to a layer containing a translucent powder layer and the colored dye may be a different layer, translucent powder A laminated type of a composite layer of a layer, a translucent powder, and a colored powder may be used. Particularly preferable is that the intermediate layer has a coating layer composed of a complex of a colored pigment and a translucent powder, and the outermost layer is a coating layer composed of a translucent powder and does not contain a pigment. It is a multi-layer structured powder. The plate-like powder has an aspect ratio can be used as long as the powder of 10 to 90, for example, mica, sericite, and one or selected from titanium mica and titanium sericite etc. or two or more preferably It can be illustrated. In particular, titanium sericite is preferable as a powder for the substrate because it embodies a natural luster and excellent covering power. The surface of the outermost layer may be treated and modified with silicones, a coupling agent having a perfluoro group, a metal soap, or an amino acid derivative. The coating of the coated plate powder of the present invention may be mechanochemical or by partial sintering. As sintering conditions, it is preferable to calcinate at 100 to 1000 ° C. under aerobic conditions or in a nitrogen stream, and as a mechanochemical method, a coating method using a planetary ball mill can be exemplified. Such is the coated platelet powder having a coating layer containing a translucent powder resides those already on the market, Ru can also use it. The preferred as commercially available products, Catalysts & Chemicals Co., Ltd. of "Dharma real leaf N" can be an example shown. The coated plate-like powder is preferably contained in the total amount of the external preparation for skin of the present invention in an amount of 0.001 to 40 mass%, more preferably 0.1 to 20 mass%. When the content is less than the lower limit, there are cases where it is difficult to sufficiently exhibit a natural finish effect, and when the content exceeds the upper limit, the degree of freedom of the dosage form as a cosmetic product may be limited.
<2> Spherical Silicone Powder Insoluble in Oil Agent The spherical silicone powder insoluble in oil agent, which is an essential component of the present invention, is a powder composed of silicone rubber and silicone resin. The spherical silicone powder insoluble in the oil of the present invention comprises vinyl dimethicone / methicone / silsesquioxane crosspolymer, diphenyldimethicone / vinyldiphenyldimethicone / silsesquioxane crosspolymer, and polymethylsilsesquioxane. Spherical silicone powders that are one or more selected from the group and insoluble in such oils are (poly) methyl (polymethoxy) siloxane, (poly) vinyl (poly) methyl (poly) methoxysiloxane, methyl phenyl (di) methoxy siloxane combined dealcoholization condensation, although Ru may be prepared by forming a cross-linked by polymerizing a vinyl group and thereafter, it is also possible to use those which are already commercially available, preferred Toss Pearl series as a commercial product (manufactured by Toshiba silicone over emissions), KSP- 00 (manufactured by Shin-Etsu Chemical Co., Ltd.) can be exemplified KSP-100, 101, 102, 103 (manufactured by Shin-Etsu Chemical Co., Ltd.). It is preferable that 0.01-20 mass% of spherical silicone powder insoluble in the oil agent is contained in the total amount of the external preparation for skin of the present invention, more preferably 0.1-10 mass%. When the blending amount is less than the lower limit, there are cases where it is difficult to sufficiently exhibit the effect of improving the spreadability, and when the blending amount exceeds the upper limit, the degree of freedom of the dosage form as a cosmetic may be limited.
また、本発明の皮膚外用剤は、これら上記の成分以外に通常化粧料で使用される任意成分を含有することができる。任意成分としては、例えば、マカデミアナッツ油、アボカド
油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類、流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、オレイン酸、イソステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、ウンデシレン酸等の高級脂肪酸類、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等、イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−２−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−２−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−２−ヘプチルウンデカン酸グリセリン、トリ−２−エチルヘキサン酸グリセリン、トリ−２−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−２−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類、ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン、アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類、脂肪酸セッケン（ラウリン酸ナトリウム、パルミチン酸ナトリウム等）、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類、塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類、イミダゾリン系両性界面活性剤（２−ココイル−２−イミダゾリニウムヒドロキサイド−１−カルボキシエチロキシ２ナトリウム塩等）、ベタイン系界面活性剤（アルキルベタイン、アミドベタイン、スルホベタイン等）、アシルメチルタウリン等の両性界面活性剤類、ソルビタン脂肪酸エステル類（ソルビタンモノステアレート、セスキオレイン酸ソルビタン等）、グリセリン脂肪酸類（モノステアリン酸グリセリン等）、プロピレングリコール脂肪酸エステル類（モノステアリン酸プロピレングリコール等）、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、ＰＯＥソルビタン脂肪酸エステル類（ＰＯＥソルビタンモノオレエート、モノステアリン酸ポリオキシエチレンソルビタン等）、ＰＯＥソルビット脂肪酸エステル類（ＰＯＥ−ソルビットモノラウレート等）、ＰＯＥグリセリン脂肪酸エステル類（ＰＯＥ−グリセリンモノイソステアレート等）、ＰＯＥ脂肪酸エステル類（ポリエチレングリコールモノオレート、ＰＯＥジステアレート等）、ＰＯＥアルキルエーテル類（ＰＯＥ２−オクチルドデシルエーテル等）、ＰＯＥアルキルフェニルエーテル類（ＰＯＥノニルフェニルエーテル等）、プルロニック型類、ＰＯＥ・ＰＯＰアルキルエーテル類（ＰＯＥ・ＰＯＰ２−デシルテトラデシルエーテル等）、テトロニック類、ＰＯＥヒマシ油・硬化ヒマシ油誘導体（ＰＯＥヒマシ油、ＰＯＥ硬化ヒマシ油等）、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類、ポリエチレングリコール、グリセリン、１，３−ブチレングリコール、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ジプロピレングリコール、ジグリセリン、イソプレングリコール、１，２−ペンタンジオール、２，４−ヘキシレングリコール、１，２−ヘキサンジオール、１，２−オクタンジオール等の多価アルコール類、ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類、グアガム、クインスシード、カラギーナン、ガラクタン、アラビアガム、ペクチン、マンナン、デンプン、キサンタンガム、カードラン、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、メチルヒドロキシプロピルセルロース、コンドロイチン硫酸、デルマタン硫酸、グリコーゲン、ヘパラン硫酸、ヒアルロン酸、ヒアルロン酸ナトリウム、トラガントガム、ケラタン硫酸、コンドロイチン、ムコイチン硫酸、ヒドロキシエチルグアガム、カルボキシメチルグアガム、デキストラ
ン、ケラト硫酸、ローカストビーンガム、サクシノグルカン、カロニン酸、キチン、キトサン、カルボキシメチルキチン、寒天、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ポリエチレングリコール、ベントナイト等の増粘剤、表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸（シリカ）、酸化アルミニウム、硫酸バリウム等の粉体類、表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類、表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類、レーキ化されていても良い赤色２０２号、赤色２２８号、赤色２２６号、黄色４号、青色４０４号、黄色５号、赤色５０５号、赤色２３０号、赤色２２３号、橙色２０１号、赤色２１３号、黄色２０４号、黄色２０３号、青色１号、緑色２０１号、紫色２０１号、赤色２０４号等の有機色素類、ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類、前記粉体類をメタクリロイルオキシアルキルフォスフォリルコリン及びアルキルメタクリレートの共重合体等の生体成分類似高分子にて被覆した粉体、パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、２−（２'−ヒドロキシ−５'−ｔ−オクチルフェニル)ベンゾトリアゾール、４−メトキシ−４'−ｔ−ブチルジベンゾイルメタン等の紫外線吸収剤類、エタノール、イソプロパノール等の低級アルコール類、ビタミンＡ又はその誘導体、ビタミンＢ６塩酸塩、ビタミンＢ６トリパルミテート、ビタミンＢ６ジオクタノエート、ビタミンＢ２又はその誘導体、ビタミンＢ１２、ビタミンＢ１５又はその誘導体等のビタミンＢ類、α−トコフェロール、β−トコフェロール、γ−トコフェロール、ビタミンＥアセテート等のビタミンＥ類、ビタミンＤ類、ビタミンＨ、パントテン酸、パンテチン等のビタミン類などが好ましく例示でき、任意成分として含有させることが可能である。特に好ましい形態としては、半透明粉体を含有する被覆層を有する被覆板状粉体として、前記半透明層に赤色色素を含有する被覆板状粉体を選択し、赤色の発現において、単独の有色色素に依存する割合をできるだけ減じ、前記被覆板状粉体による赤色発現を利用する形態が好ましく例示でき、具体的には、赤色を担っているベンガラ又はハイドロジェンメチルポリシロキサン焼付処理（処理量２質量％；単にシリコーン処理と称する場合もある）ベンガラの含有量を１．５質量％以下、より好ましくは１質量％以下に抑えることである。この様な形態を採用することにより、仕上がりの自然さが向上するとともに、化粧効果の持続性も著しく向上する。
Moreover, the skin external preparation of this invention can contain the arbitrary components normally used by cosmetics other than these said components. The optional components, e.g., macadamia nut oil, Abou transient oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil, Hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba oil, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol , Behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpolysiloxa , Chain polysiloxanes such as diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine Oil agents such as silicone oil such as modified polysiloxane such as modified polysiloxane, fatty acid soap (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, stearyl chloride Cationic surfactants such as trimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium Muhydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan mono) Stearates, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters ( POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid ester (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonyl phenyl ether, etc.) ), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose Nonionic surfactants such as fatty acid esters and alkyl glucosides, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol , Dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol and other polyhydric alcohols, pyrrolidone carboxylic acid Moisturizing ingredients such as sodium, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate , Dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxy Cyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid , locust bean gum , succinoglucan , carolinic acid , chitin , chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, sodium polyacrylate, polyethylene Thickeners such as glycol and bentonite, surface may be treated, powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate Surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, titanium mica, fish Phosphorous foil, bismuth oxychloride, etc. Red, No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201 Organic dyes such as red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204, polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, etc. Organic powders, powders coated with a bio-component-like polymer such as a copolymer of methacryloyloxyalkylphosphorylcholine and alkyl methacrylate, paraaminobenzoic acid UV absorber, anthranilic acid UV Absorber, salicylic acid UV absorber, cinnamic acid UV absorber, benzophenone UV absorber, sugar UV Collector, ultraviolet absorbers such as 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, lower alcohols such as ethanol and isopropanol Vitamin A or derivatives thereof, vitamin B6 hydrochloride , vitamin B6 tripalmitate , vitamin B6 dioctanoate , vitamin B2 or derivatives thereof , vitamin B12 such as vitamin B12 , vitamin B15 or derivatives thereof, α-tocopherol , β-tocopherol , Vitamin E such as γ-tocopherol and vitamin E acetate, vitamin D, vitamin H, vitamins such as pantothenic acid, pantethine and the like can be preferably exemplified and can be contained as an optional component. As a particularly preferred form, a coated plate-like powder containing a red pigment in the semi-transparent layer is selected as a coated plate-like powder having a coating layer containing a semi-transparent powder. reduced as possible a percentage that depends on the colored dye form to use the red expression by the coated platelet powder can be preferably exemplified, specifically, red iron oxide plays a red or hydrogen methyl polysiloxane baking (Treatment amount: 2% by mass; sometimes simply referred to as silicone treatment) The content of Bengala is 1.5% by mass or less, more preferably 1% by mass or less. By adopting such a form, the natural finish is improved and the sustainability of the makeup effect is also significantly improved.
本発明の皮膚外用剤の剤形は特段制限されるものではないが、メークアップ化粧料が好ましく、ファンデーションがより好ましい。ファンデーションとしては、リキッドファンデーション、パウダーファンデーションが例示できるが、パウダーファンデーションが好ましい。前記の被覆板状粉体と油剤には不溶の球状のシリコーン粉体を皮膚外用剤に用いる場合、粉体に所望により５〜２５質量％の油脂成分をコーティングし、これを固形に成形することにより皮膚外用剤として調製可能である。 Dosage form of the external preparation for skin of the present invention but are not otherwise limited, preferably make-up cosmetics, foundation is not more preferable. The foundation, liquid foundation, but powder foundation can be exemplified, Pa Uda foundation is preferred. When using a silicone powder spherical insoluble in coated platelet powder and oil of the skin external preparation, it optionally the powder coated with 5-25 wt% of fat component, to mold it into solid Thus, it can be prepared as a skin external preparation.
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明がかかる実施例にのみに限定されないことは言うまでもない。 Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.
＜実施例１＞
以下の表１に示す処方に従って、パウダーファンデーションAを調製した。
まず（Ａ）をヘンシェルミキサーで混合した後、（Ｂ）を加え、更に均一混合する。この均一混合物をパルベライザーにて粉砕したものを加圧成型した。
<Example 1>
Powder foundation A was prepared according to the formulation shown in Table 1 below.
After First, (A) was mixed with unnatural death E Rumikisa added (B), more uniform mixing. A product obtained by pulverizing this uniform mixture with a pulverizer was subjected to pressure molding.
＜実施例２＞
以下の表２に示す処方に従って、クリームファンデーションAを調製した。
まず（Ｃ）を７５℃下にて均一攪拌したものに、（Ｂ）を均一分散させる。次いで予め混合させた（Ａ）を添加後、再び均一攪拌させる。更に７５℃に加温した（Ｄ）を徐々に加え、攪拌することにより乳化物を得る。この乳化物を水冷にて３０℃まで攪拌しながら冷却した。
<Example 2>
Cream foundation A was prepared according to the formulation shown in Table 2 below.
First, (C) is uniformly dispersed at 75 ° C., and (B) is uniformly dispersed. Next, after adding (A) mixed in advance, the mixture is uniformly stirred again. Further, (D) heated to 75 ° C. is gradually added and stirred to obtain an emulsion. The emulsion was cooled to 30 ° C. with water cooling while stirring.
＜実施例３＞
以下の表３に示す処方に従って、固形ファンデーションAを調製した。
まず（Ｂ）を９５℃下にて溶解、均一攪拌したものに、（Ａ）を均一分散させる。この均一分散物を耐熱性の容器に充填後、空冷にて３０℃まで冷却した。
<Example 3>
According to the formulations shown in Table 3 below were prepared solid type foundation A.
First, (B) is dissolved at 95 ° C. and uniformly stirred, and (A) is uniformly dispersed. The uniform dispersion was filled in a heat-resistant container and then cooled to 30 ° C. by air cooling.
（ファンデーションの延展性評価）
表４に示す実施例４、比較例１乃至比較例３について延展性評価を実施した。
評価方法は表４に示す各パウダーファンデーションをパフにとり、黒色人工皮革に一定量塗布する。塗布表面を摩擦感テスター KES-SE-STP（カトーテック社製）を用いて、ＭＩＵ（平均摩擦係数）およびＭＭＤ（平均摩擦係数の変動値）を測定した。各測定値は以下のような感触に関する指標とした。
ＭＩＵ（平均摩擦係数）・・・「のびの軽さ（滑りやすさ）」の指標。値が小さいほど伸びが軽く滑りやすい。
ＭＭＤ（平均摩擦係数の変動値）・・・「なめらかさ」「ざらつき」の指標。値が小さいほどなめらかでざらつきがない。
その結果を表５に示す。
(Evaluation of spreadability of foundation)
Table 4 embodiment illustrated in 4, was performed spreadability evaluated for Comparative Examples 1 to 3.
Evaluation method takes each powder foundation shown in Table 4 to puff, a fixed amount applied to black people Engineering leather. MIU (average friction coefficient) and MMD (variation value of average friction coefficient) were measured on the coated surface using a friction tester KES-SE-STP (manufactured by Kato Tech). Each measured value was used as an index relating to the following feeling.
MIU (average coefficient of friction): An indicator of "lightness of spread (ease of sliding)". The smaller the value, the lighter the elongation and the easier it is to slip.
MMD (fluctuation value of average friction coefficient): An index of “smoothness” and “roughness”. The smaller the value, the smoother and less grainy.
The results are shown in Table 5.
表５の通り、被覆板状粉体と油剤には不溶の球状のシリコーン粉体を含有したパウダーファンデーションＡ−２において、ＭＩＵ値およびＭＭＤ値から延展性が良好であることが明らかである。 As shown in Table 5, in the powder foundation A- 2 containing spherical silicone powder that is insoluble in the coated plate-like powder and oil, it is clear that the spreadability is good from the MIU value and the MMD value.
（ファンデーションの使用試験）２１〜４２才の女性パネラー１０名に、実施例及び比較例のパウダーファンデーションを一日に一種類ずつ、朝９時に約０．１ｇとなる量を顔面に塗布してもらい、各パウダーファンデーションについて、自然な仕上がり感とのびの２項目について表６の基準により評価してもらった。評価結果を表７に示す。 (Foundation use test) 10 female panelists aged 21 to 42 years old apply the powder foundations of the examples and comparative examples one day a day to the face in an amount of about 0.1 g at 9:00 am Each powder foundation was evaluated according to the criteria shown in Table 6 with respect to natural finish feeling and two items. Table 7 shows the evaluation results.
上記評価試験結果に明らかなように、本発明のパウダーファンデーションは、従来のものと比較して自然な仕上がりが得られ、塗布時ののびが良いものであった。 As is apparent from the evaluation test results, the powder foundation of the present invention has a natural finish as compared with the conventional one, and has a good spread at the time of application.
＜実施例５＞
実施例３と同様に表９の処方に従い固形ファンデーションBを作成した。このものについての自然な仕上がり感、のび、化粧効果の持続性の３項目について、表８の評価尺度に従い、専門パネラーを用いて行った。結果は表１０に示すとおりであり、ベンガラ、シリコーン処理ベンガラの含有量は１．５質量％以下に設定することが好ましいことが判る。
<Example 5>
Solid foundation B was prepared according to the formulation in Table 9 as in Example 3. According to the evaluation scale shown in Table 8, a specialized panel was used for the three items of the natural finish feeling, the spread, and the persistence of the makeup effect. A result is as showing in Table 10, and it turns out that it is preferable to set content of a bengara and a silicone processing bengara to 1.5 mass% or less.
本発明は、メークアップ化粧料等の皮膚外用剤として応用できる。 The present invention can be applied as a skin external preparation such as makeup cosmetics.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008150205A JP2009292791A (en) | 2008-06-09 | 2008-06-09 | Skin care preparation having excellent natural finish and spreadability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008150205A JP2009292791A (en) | 2008-06-09 | 2008-06-09 | Skin care preparation having excellent natural finish and spreadability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009292791A JP2009292791A (en) | 2009-12-17 |
| JP2009292791A5 true JP2009292791A5 (en) | 2011-07-21 |
Family
ID=41541328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008150205A Pending JP2009292791A (en) | 2008-06-09 | 2008-06-09 | Skin care preparation having excellent natural finish and spreadability |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2009292791A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015000864A (en) * | 2013-06-18 | 2015-01-05 | ロレアル | Cosmetic composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11209239A (en) * | 1998-01-14 | 1999-08-03 | Pola Chem Ind Inc | Natural looking makeup cosmetics |
| JPH11217315A (en) * | 1998-01-27 | 1999-08-10 | Pola Chem Ind Inc | Makeup cosmetic showing natural appearance |
| JP4145496B2 (en) * | 2000-08-31 | 2008-09-03 | 三好化成株式会社 | New composite powder and cosmetics containing the same |
| JP3893387B2 (en) * | 2004-03-19 | 2007-03-14 | 花王株式会社 | Makeup cosmetics |
| JP2006213651A (en) * | 2005-02-03 | 2006-08-17 | Kose Corp | Solid powder cosmetic |
| JP2006248971A (en) * | 2005-03-10 | 2006-09-21 | Kose Corp | Three-dimensional effect-emphasizing cosmetic |
| JP4731242B2 (en) * | 2005-08-03 | 2011-07-20 | ポーラ化成工業株式会社 | Cosmetics suitable for base cosmetics having a pore correcting action |
| JP5080075B2 (en) * | 2006-12-13 | 2012-11-21 | 株式会社 資生堂 | Method for improving skin sagging and kit for improving skin sagging |
-
2008
- 2008-06-09 JP JP2008150205A patent/JP2009292791A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4880078B1 (en) | Powder cosmetics | |
| JP6178089B2 (en) | Dullness improvement cosmetic | |
| JP5340588B2 (en) | Cosmetics for correcting pores | |
| JP4734034B2 (en) | Cosmetics containing powder | |
| JP2009292791A5 (en) | ||
| JP2006335641A5 (en) | ||
| JP6346465B2 (en) | Sunscreen cosmetics | |
| JP2013129622A (en) | Solid powder cosmetic | |
| JP2009292791A (en) | Skin care preparation having excellent natural finish and spreadability | |
| JP6614592B2 (en) | Brightening cosmetics | |
| JP2015178473A (en) | makeup cosmetics | |
| JP4741821B2 (en) | Skin external preparation suitable for sebum shine prevention | |
| JP2015030723A (en) | Emulsifier type sunscreen cosmetic | |
| JP5192119B2 (en) | Solid cosmetics | |
| JP2009155209A (en) | Oil-in-water type emulsion composition and method for producing the same | |
| JP2006160675A (en) | Makeup cosmetic | |
| JP5719131B2 (en) | Multicolor solid makeup cosmetics | |
| JP2007161615A5 (en) | ||
| JP6386756B2 (en) | Makeup cosmetics | |
| JP2006160675A5 (en) | ||
| JP6960806B2 (en) | Cosmetics | |
| JP6219606B2 (en) | Lip cosmetics | |
| JP4676730B2 (en) | Emulsifier type skin external preparation | |
| JP6408768B2 (en) | Sunscreen cosmetics | |
| JP6082178B2 (en) | Powder cosmetics for makeup |