JP2009233074A - Hazardous substance removal material and air cleaning device using same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hazardous substance removal material capturing and inactivating hazardous substances such as bacteria, molds, virus, pollen and allergen and preventing re-proliferation of bacteria and molds on a used antibody, and also to provide an air cleaning device equipped with an antibody filter consisting of the same hazardous substance removal material. <P>SOLUTION: This hazardous substance removal material supports (A) an antibody, and (B) inorganic silver salt whose logarithmic value (pK<SB>sp</SB>) of an inverse number of a solubility product constant at pH 7 and 25°C is 8-14 to a carrier, and an air cleaning device using the same is provided. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a harmful substance removal material, and more specifically, a harmful substance that selectively supports capture and inactivation of various harmful substances such as bacteria, viruses, and allergens by supporting a chicken egg antibody and an inorganic silver salt on a carrier. It relates to a material removal material.

  In recent years, in various industries such as the semiconductor manufacturing industry, pharmaceutical manufacturing industry, food processing, offices, hospitals, nursing homes for the elderly and in the consumer sector, there has been an increasing demand for cleanliness, safety, and hygiene in the workplace and living environment. The reality is. For this reason, more than ever, various devices and products with antibacterial and antifungal functions are widely used in air purification filter members for clean room air filters, food processing and air conditioning for offices, and home air conditioners. Used / provided.

  In particular, infectious diseases of specific viruses are prevalent in facilities such as hospitals and nursing homes for the elderly, and an immediate countermeasure is required. From these backgrounds, it is desired to develop a treatment member that has both a high removal function for these specific viruses and a function capable of dealing with a wide range of bacteria and sputum.

  For example, Patent Document 1 discloses a harmful substance that captures harmful substances such as bacteria, mold, viruses, and allergens floating in a gas phase atmosphere by using a harmful substance removing agent that uses an antibody and a carrier that has been subjected to anti-fouling treatment. Substance removal materials have been proposed.

Patent Document 2 describes an antibacterial member in which an anion is brought into contact with the surface of silver particles formed on a semiconductor layer that exhibits a photocatalytic action to form a sparingly soluble silver salt. It describes an antibacterial agent that suppresses the dissolution rate of silver.
JP 2004-313755 A Japanese Patent Laid-Open No. 08-133919

  Higher hazardous substance removal performance is required for hazardous substance removal materials. As described above, in the conventional technique using an antibody and a carrier subjected to anti-epileptic processing, the antibody itself tends to be deteriorated by the antibacterial / anti-anti-elastogenic material.

  An object of the present invention is to provide a harmful substance removing agent that has the ability to remove a specific virus at a higher rate and the ability to remove a wide variety of bacteria and sputum.

As a result of intensive studies to achieve the above object, the present inventor made an inorganic silver salt carried on a fibrous carrier carrying an egg egg antibody, and the bacteria captured on the carrier were inactivated. In addition, the present invention was completed by finding that neither moths nor bacteria were newly propagated on this carrier.
That is, the present invention has the following configuration.

<1>
(A) a chicken egg antibody;
(B) an inorganic silver salt having a logarithmic value (pK _sp ) of the reciprocal of the solubility product at pH 7 and 25 ° C. of 8 to 14,
Hazardous substance removal material with carrier supported

<2>
The hazardous substance removing material according to <1>, wherein the inorganic silver salt is silver chloride or silver bromide.

<3>
The toxic substance removing material as described in <1> or <2> above, wherein the sphere equivalent diameter of the inorganic silver salt is 0.5 μm or less.

<4>
A case body having an intake portion for taking air into the interior and an exhaust portion for sending air to the outside;
A photocatalyst filter disposed in the flow path, having a blower part for blowing air to a flow path formed between the intake part and the exhaust part, and a layer containing a photocatalyst;
A light irradiation unit for irradiating light to the photocatalytic filter;
The hazardous substance removing material according to any one of the above <1> to <3> disposed in the flow path,
A light shielding member is provided between the light irradiation unit and the harmful substance removing agent to allow the air to flow and to block the passage of the light when viewed in the air flowing direction. The member has a frame disposed in the flow path, and a plurality of light shielding plates formed on the frame and arranged in an inclined state at the same angle.

  According to the present invention, it is possible to effectively capture and inactivate harmful substances such as bacteria, sputum, viruses, pollen and allergens, and to provide a harmful substance removing material having an antibacterial effect without deteriorating chicken egg antibodies. it can.

  In the following, embodiments of the hazardous substance removing material and the air cleaning device of the present invention will be described in more detail.

<Carrier>
The carrier used for the hazardous substance removing material of the present invention is not particularly limited, but a carrier constituted by fibers is preferable, and the carrier can be constituted in the form of a woven fabric, a nonwoven fabric or the like. Examples of the fibers include, but are not limited to, synthetic fibers such as polyester, cellulose ester, polyvinyl alcohol, vinylon, acrylic, polyurethane, polyamide, natural fibers such as cotton, silk, wool, and regenerated fibers such as rayon. I can do it. These fibers may be combined. For the purpose of improving the strength and dimensional stability, the carrier may be reinforced with other suitable structural materials such as metals, polymer materials, and ceramics. These reinforcing materials are desirably used for portions other than the substantially outermost surface of the side surface to which the harmful substance removing material is supplied (for example, used on the opposite surface of the side surface or a core material).

The fiber used as a carrier in the present invention can be produced by a general production method such as melt spinning, wet spinning, dry spinning, wet drying spinning, or physical treatment (for example, strong mechanical shearing treatment using an ultra-high pressure homogenizer). In order to ensure stable quality, it is preferable to use dry spinning or wet-dry spinning. In order to produce uniform fibers with an average fiber diameter of 100 nm or less, further processing techniques, 2005, 40, No. 2, 101, and 167; Polymer International, 1995, 36, 195- 201; Polymer Preprints, 2000, 41 (2), 1193; Journal of Macromolecular Science: Physics, 1997, B36, 169, etc. It is preferable to employ the electrospinning method.

  Solvents used for spinning include chlorinated solvents such as methylene chloride, chloroform and dichloroethane, amide solvents such as dimethylformamide, dimethylacetamide and N-methylpyrrolidone, and ketones such as acetone, ethyl methyl ketone, methyl isopropyl ketone and cyclohexanone. Any solvent that dissolves the resin used for the synthetic resin fiber, such as a solvent, an ether solvent such as THF or diethyl ether, an alcohol solvent such as methanol, ethanol, or isopropanol, or water can be used. These solvents may be used alone or in combination of two or more.

  When the electrospinning method is employed, a salt such as lithium chloride, lithium bromide, potassium chloride, or sodium chloride may be further added to the resin solution.

  It is desirable that the fibers constituting the carrier have a structure in which a three-dimensional network is formed by partial adhesion. By adopting such a structure, it is possible to improve processing and practical mechanical resistance, and to improve the reliability of the hazardous substance removing material. Moreover, the retention property of an antibody can be improved. The adhesion between fibers can be observed by a method such as SEM. The density of the bonding points between the fibers is preferably 10 or more per 1 mm square with respect to the projected surface area of the harmful substance removing material, and more preferably 100 or more.

  As a method for forming an adhesion point, it may be formed by an adhesion formed by a dry spinning method or a fusion point formed by a melt spinning method, or after spinning, addition of an adhesive, a plasticizing solvent, etc. You may perform the adhesion point formation process by. From the viewpoint of production cost, it is preferable to form adhesion points by a dry spinning method using an appropriate solution formulation.

The carrier is preferably sterilized. The sterilization method is not particularly limited as long as the sterilization method does not deteriorate the carrier, but sterilization by radiation or sterilization by gas is preferable.
Examples of radiation sterilization methods include gamma sterilization and electron beam sterilization. Among these, the method using gamma ray sterilization is preferable.
Examples of the gas sterilization method include methods using ethylene oxide gas sterilization and chlorine dioxide gas sterilization. Among these, the method using ethylene oxide gas sterilization is preferable.

<(A) Egg antibody>
The egg egg antibody used in the present invention is a protein that specifically reacts (antigen-antibody reaction) with a specific harmful substance (antigen), and usually has a molecular size of 7 to 8 nm and has a Y-shaped molecule. It has a form. Of the Y-shaped molecular structure of an antibody, a pair of branch parts is called Fab and a trunk part is called Fc, and among these, a toxic substance is captured at the Fab part.

  The type of the antibody corresponds to the type of harmful substance that can be captured. Examples of harmful substances captured by antibodies include bacteria, molds, viruses, allergens, and mycoplasmas. Specifically, examples of bacteria include gram-positive bacteria, Staphylococcus (S. aureus and Staphylococcus epidermidis), micrococcus, anthrax, cereus, Bacillus subtilis, acne, and gram-negative bacteria. And Pseudomonas aeruginosa, Serratia, Sephacia, Streptococcus pneumoniae, Legionella, and Mycobacterium tuberculosis. Examples of molds include Aspergillus, Penicillius, and Cladosporium. Examples of the virus include influenza virus, coronavirus (SARS virus), adenovirus, rhinovirus and the like. Examples of allergens include pollen, mite allergen, cat allergen and the like.

Examples of the method for producing the antibody include, for example, a method in which an antigen is administered to an animal such as a goat, horse, sheep, or rabbit, and a polyclonal antibody is purified from the blood, and a spleen cell and a cultured cancer cell of the animal to which the antigen is administered. Methods for purifying monoclonal antibodies from cell cultures and body fluids (such as ascites) of animals that have been transplanted with the cultures, purified antibodies from genetically modified bacteria, plant cells, or animal cell cultures into which antibody-producing genes have been introduced And a method for purifying avian egg antibodies from egg yolk powder obtained by administering an antigen to birds to produce immunized eggs and sterilizing and spray-drying the yolk liquid. Among these, the method of obtaining an antibody from an avian egg can easily obtain a large amount of the antibody and can reduce the cost of a harmful substance removing material. Examples of birds include chickens and ostriches.
An avian egg antibody can be obtained by purifying an egg yolk powder obtained by administering an antigen to a bird to produce an immunized egg, and sterilizing and spray-drying the yolk liquid. In the method of obtaining antibodies from avian eggs, antibodies can be obtained easily and in large quantities, and the cost of the harmful substance removing material can be reduced.

  As a method of supporting (immobilizing) the antibody on the carrier, in addition to a method of physically adsorbing the antibody on the carrier, the carrier is silanized using γ-aminopropyltriethoxysilane and the like, and then glutarylated. A method of introducing an aldehyde group onto the surface of the carrier with aldehyde or the like and covalently bonding the aldehyde group and the antibody, a method of immobilizing the antibody on the carrier by ionic bonding by immersing an untreated carrier in an aqueous solution of the antibody, a specific method A method of introducing an aldehyde group into a carrier having a functional group and covalently bonding the aldehyde group and the antibody, a method of ion-binding the antibody to a carrier having a specific functional group, and coating the carrier with a polymer having a specific functional group A method of introducing an aldehyde group later and covalently binding the aldehyde group to the antibody can be mentioned.

Here, examples of the specific functional group include an NHR group (R is any alkyl group other than H, methyl, ethyl, propyl, and butyl), NH ₂ group, C ₆ H ₅ NH ₂ group, and CHO group. , COOH group, and OH group.

  Also, there is a method in which the functional group on the surface of the carrier is converted to another functional group using BMPA (N-β-Maleimidopropionic acid) or the like, and then the functional group and the antibody are covalently bonded (SH group in BMPA). Are converted to COOH groups).

  Furthermore, there is a method in which a molecule (Fc receptor, protein A / G, etc.) that selectively binds to the Fc portion of the antibody is introduced onto the surface of the carrier and the antibody Fc is bound thereto. In this case, the Fab that captures the harmful substance faces outward with respect to the carrier, and the probability of contact of the harmful substance with the Fab increases, so that the harmful substance can be efficiently captured.

The antibody may be supported on a carrier via a linker. In this case, the degree of freedom of the antibody on the carrier is increased and access to harmful substances is facilitated, so that high removal performance can be obtained. Examples of the linker include bi- or higher-valent cross-linking reagents, specifically maleimide, NHS (N-Hydroxysuccinimidyl) ester, imide ester, EDC (1-Ethyl-3- [3-dimethylaminopropyl] carbodiimido), There is PMPI (N- [p-Maleimidophenyl] isocyanate), which is selective to target functional groups (SH group, NH ₂ group, COOH group, OH group) and non-selective. Moreover, the distance (space arm) between crosslinks also changes for every crosslink reagent, and it can select in the range of about 0.1 nm-3.5 nm according to the target antibody. From the viewpoint of efficiently capturing harmful substances, those that bind to the Fc of the antibody as a linker are preferred.

  As a method for introducing a linker, either a method in which a linker is bound to an antibody and then further bound to the antibody, or a method in which a linker is bound to a carrier and the antibody is bound to the linker on the carrier is possible. is there.

The antibody is supported on the carrier by attaching the solution containing the egg egg antibody to the carrier. The method for attaching the chicken egg antibody solution to the carrier is not particularly limited, and examples thereof include a method of immersing the carrier in the chicken egg antibody solution, spray coating, ink jet coating, and curtain coating.
What is necessary is just to produce the solution containing a chicken egg antibody by melt | dissolving the chicken egg antibody obtained as mentioned above in physiological saline or phosphate buffered saline. The concentration of the chicken egg antibody in the solution may be 0.001% by mass to 10% by mass, preferably 0.005% by mass to 5% by mass, and more preferably 0.01% by mass to 1% by mass. The solution may contain additives such as stabilizers, antibacterial agents and antifungal agents.

  In the present invention, it is preferable to use a solution containing a chicken egg antibody after filtering with a filter having a pore size of 0.5 μm or less. By filtering with a filter having a pore size of 0.5 μm or less, it is possible to suppress the growth of germs and molds in the produced harmful substance removing material.

<(B) Inorganic silver salt>
The hazardous substance removing material of the present invention contains an inorganic silver salt (B) having a logarithmic value (pK _sp ) of the reciprocal of the solubility product at pH 7 and 25 ° C. of 8-14.
The inorganic silver salt (B) is preferably a hardly soluble salt, and its ionization / silver ion concentration in a saturated solution system at pH 7 is expressed by a logarithmic value (pK _sp ) of the reciprocal of its solubility product (25 ° C.). , PK _sp = 8 to 14 in specific inorganic silver salt, preferably silver chloride or silver bromide.

When this pK _sp value is less than 8, the silver ion concentration increases, the silver ions attacking the antibody increase, and the destruction of the antibody occurs. On the other hand, if the pK _sp value is greater than 14, the silver ion concentration becomes too low and the desired antibacterial effect cannot be obtained.

The inorganic silver salt pKsp is disclosed in, for example, TH Theme of the Photographic Process by THJames, Macmillan Publishing Co. Inc., New York (fourth edition, 1977), Chapters 1 to 7-10. It can select suitably with reference and can be set as the inorganic silver salt (B) of this invention.
Examples of the inorganic silver salt (B) include US Pat. No. 4,500,626, column 50, 4,628,021, Research Disclosure Journal (hereinafter abbreviated as RD) No. 17, 029 (1978), ibid. 17, 643 (December, 1978) 22-23, ibid. 18, 716 (November 1979) 648, ibid. 307, 105 (November 1989) 863-865, JP-A-62-253159, JP-A-64-13546, JP-A-2-236546, JP-A-3-110555, and Grafkide, "Photograph Physics and Chemistry". Published by Paul Monte (P. Glafkides, Chemie et Pisique Photographic, Paul Montel, 1967), "Photo Emulsion Chemistry" by Duffin, published by Focal Press (G.F. "Manufacture and coating of photographic emulsions" by Zericman et al., Published by Focal Press (VL Zelikman et al., Making and Coating Photographic)
Emulsion, Focal Press, 1964) and the like can be used.

In the present invention, an inorganic silver salt dispersion is adhered to a carrier to be supported on the carrier. The method of attaching is not particularly limited, and examples thereof include a method of immersing a carrier in an inorganic metal salt dispersion, spray coating, ink jet coating, and curtain coating. A binder is preferably used for the metal salt dispersion of the organic compound. The binder is preferably a water-soluble binder, and examples thereof include polyvinyl alcohol, polyvinyl pyrrolidone, gelatin, and carboxymethyl cellulose. Further, it is more preferable to mix the antibody solution and the dispersion of the inorganic metal salt and then carry the mixture on a carrier because the manufacturing process can be simplified.
The inorganic silver salt of the present invention preferably has a sphere equivalent diameter of 0.5 μm or less.

<How to use>
The hazardous substance removing material obtained by the production method of the present invention can remove harmful substances in the gas phase or liquid phase. This harmful substance removing material can be used even in a dry environment where the antibody faces the gas phase, and can be used for a filter for an air cleaner, a mask, a wipe sheet, and the like. The hazardous substance removing material obtained by the production method of the present invention can be stably stored for a long period of time.
The hazardous substance removing material obtained by the production method of the present invention is preferably packaged using a package that does not transmit ultraviolet rays. By using such a package, it is possible to prevent the deterioration of the antibody due to ultraviolet rays, and further stable storage for a long period of time is possible. As a package, an aluminum foil film and an aluminum vapor deposition film are preferable, and a multilayer film containing these is also preferably used.

<Manufacture of hazardous substance removal material>
The antibody and the inorganic silver salt may be applied by separately applying the antibody solution and the inorganic silver solution, or may be applied as an antibody-inorganic silver mixed solution. The latter is preferable from the viewpoint of simplification of the process. The amount of the antibody or inorganic silver salt applied depends on the purpose of use, but it is preferable that a sufficient amount is applied to remove harmful substances during the period of use.

<Air cleaning device>
The hazardous substance removing material of the present invention is preferably used as an antibody filter of an air cleaning device.
The antibody filter using the hazardous substance removing material of the present invention can be used in an ordinary air cleaning device. Specifically, a case main body having an intake portion that takes air into the interior and an exhaust portion for sending air to the outside, and air that blows air into a flow path formed between the intake portion and the exhaust portion It is preferable to provide an air cleaning device including a section and the hazardous substance removing material of the present invention disposed in the flow path.

  An air cleaning device according to the present invention includes a case main body having an intake portion for taking air inside, an exhaust portion for sending air to the outside, and a flow path formed between the intake portion and the exhaust portion. A photocatalyst filter having a layer containing a photocatalyst and disposed in the flow path, a light irradiation unit for irradiating light to the photocatalyst filter, and a harmful effect of the present invention disposed in the flow path A substance removing material, which allows the air flow between the light irradiation unit and the harmful substance removing agent, and shields the passage of the light in a state seen in the air flowing direction. A light shielding member is provided, and the light shielding member includes a frame body arranged in the flow path, and a plurality of light shielding plates formed on the frame body and arranged in an inclined state at the same angle.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
FIG. 1 is a diagram showing a configuration of an embodiment of an air cleaning device according to the present invention. FIG. 2 is a view of the air cleaning device of FIG. 1 as viewed from the intake side. FIG. 3 is a view of the air purification device of FIG. 1 as viewed from the exhaust side. FIG. 4 is a cross-sectional view taken along a cross section parallel to the air flow path of the air cleaning device of FIG. 1.

  The air cleaning device 10 includes a case body 11 having a substantially rectangular shape having a predetermined space inside. As shown in FIG. 2, a plurality of air inlets 21 are formed in the side surface 11 a on the air inlet side of the case body 11, and these air inlets 21 function as an air intake part for taking air into the case body 11. To do. Further, as shown in FIG. 3, a plurality of exhaust ports 23 are formed on the side surface 11 b on the exhaust side of the case body 11, and these exhaust ports 23 discharge the air to the outside of the case body 11. Function as.

  A flow path that communicates from the intake port 21 to the exhaust port 23 is formed inside the case body 11. When the air cleaning device 10 is driven, the air taken in from the intake port 21 flows in the direction of arrow F in FIG. 1 and is sent out from the exhaust port 23. Hereinafter, in the embodiment according to the present invention, the intake side is the upstream side and the exhaust side is the downstream side with respect to the flow path.

  A photocatalytic filter 12 is disposed in the flow path in the case body 11. The photocatalytic filter 12 of the present embodiment has a substantially rectangular pair shape, has a plane that is substantially equal to the cross-sectional area of the flow path and is parallel to each other, and the flow of air that flows through the flow path (arrow F) ) To be perpendicular to the). In the present embodiment, the photocatalytic filter 12a is disposed on the upstream side, and the photocatalytic filter 12b is disposed on the downstream side.

The photocatalytic filter has a porous fiber layer such as a nonwoven fabric, an inert titanium layer, and an active titanium layer on the inert titanium layer.
As the photocatalyst, titanium oxide (TiO ₂ ) is mainly used, but in addition, zinc oxide (ZnO), cerium oxide (Ce ₂ O ₃ ), terbium oxide (Tb ₂ O ₃ ), magnesium oxide (MgO). ), Erpium oxide (Er ₂ O ₃ ), potassium tantalate (KTaO ₃ ), cadmium sulfide (CdS), cadmium selenide (CdSe), and [Ru (bpy) ₃ ] ²⁺ , Co complexes, etc. are applicable. is there. Note that it is desirable to use fine particles of anatase crystal as the active titanium oxide. The fiber layer having a basis weight be of ^{100g / m 2 ~300g / m 2} , the pressure loss is the initial pressure loss in the standard wind speed 2.5 m / s, it is preferable to use the 20～90Pa.

  An antibody filter 15 is provided on the downstream side of the photocatalytic filter 12. The antibody filter 15 can have the same size and shape as the photocatalytic filter 12.

  The photocatalytic filters 12a and 12b and the antibody filter 15 are held in a filter cassette 50, and are disposed at predetermined positions by mounting the filter cassette 50 on the case body 11. In the present embodiment, the photocatalytic filters 12a and 12b and the antibody filter 15 have a long plate shape, extend in a direction perpendicular to the flow path F, and allow the flow of air while being visually observed. It is arranged to shield.

  A light irradiation unit 14 that irradiates light to the photocatalytic filter 12 is provided in the flow path inside the case body 11. In this embodiment, the light irradiation part 14 is arrange | positioned between the upstream photocatalyst filter 12a and the downstream photocatalyst filter 12b. The light irradiation unit 14 emits ultraviolet light having a wavelength of about 300 nm to 420 nm, which is a wavelength with which the photocatalyst reacts. In the present embodiment, a fluorescent lamp is used as the light source of the light irradiation unit 14. However, the present invention is not limited to this. For example, an LED (Light Emitting Diode) or other ultraviolet irradiation device may be used. A glow lamp for lighting a fluorescent lamp may be provided in the vicinity of the light irradiation unit 14 of the present embodiment.

  As shown in FIGS. 1 and 4, a blower 16 is provided downstream of the flow path of the case body 11 and immediately before the exhaust port 23 (in the vicinity of the upstream side). In the present embodiment, an axial fan is used as the blower unit 16. At the time of driving, the air blower 16 sends the air inside the flow path from the downstream exhaust port 23 by the rotation of the fan, so that the air is taken in from the upstream intake port 21 in the flow path, and the air is taken along the flow path. An air flow indicated by an arrow F in FIG. 1 is generated, such as sending the gas from the exhaust port 23 on the downstream side. The blower unit 16 is not limited to an axial fan, and a sirocco fan or the like may be used. In the present embodiment, the air blowing unit 16 is provided on the downstream side of the flow path. However, the air blowing unit 16 may be provided on the upstream side of the flow path, or the upstream side and the downstream side of the flow path. It is good also as a structure which provides the ventilation part 16 in both.

  Further, in the air cleaning device 10, the power supply circuit 32 that supplies electricity to the light irradiation unit 14 and the air blowing unit 16, the motor control unit 33, and the voltage of the light irradiation unit 14 are converted inside the case body 11. A possible transformer 34 is provided. A power switch 24 is provided on the side surface 11 b on the exhaust side of the case body 11. In addition, on the intake side 11 a of the case body 11, an air volume adjustment unit 26 is provided that allows a user to adjust the flow rate of air blown from the blower unit 16.

  Further, as shown in FIG. 4, light from the light irradiation unit 14 is prevented from leaking from the intake port 21 to the outside of the case body 11 on the upstream side of the flow path and on the downstream side of the intake port 21. Therefore, a light shielding member 42 to be described later is provided. If it carries out like this, it can prevent that harmful light to a human body, such as an ultraviolet-ray, will be irradiated outside at the time of a drive, and can ensure safety.

  As shown in FIGS. 1 and 4, in the air cleaning device 10 of the present embodiment, a light shielding member 44 is provided between the light irradiation unit 14 and the antibody filter 15. Further, another light shielding member 42 is provided near the downstream side of the air inlet 21 in the flow path. The configuration of the light shielding members 42 and 44 will be described later.

Next, the control system of the air cleaning apparatus 10 of this embodiment is demonstrated.
FIG. 5 is a block diagram showing a control system of the air cleaning device of the present embodiment. In the embodiments described below, members having the same configuration / action as those already described are denoted by the same or corresponding reference numerals in the drawings, and description thereof is simplified or omitted. When the air cleaning device 10 is driven, a predetermined voltage is supplied to the motor control unit 33, the light irradiation unit 14, and the transformer 34 by starting the power supply circuit 32. By setting the transformer 34 to a predetermined frequency (for example, frequencies 50 Hz and 60 hertz), the voltage applied to drive the light irradiation unit 14 can be switched. By driving the motor control unit 33, the air blowing unit 16 is driven, and air starts to flow along the flow path of the case body 11. Simultaneously with the start of driving of the blower 16 or before and after the start of the drive, the light irradiation unit 14 is driven to start the light irradiation, and the photocatalytic filter 12 generates active oxygen and flows by the blower 16. The active oxygen is diffused into the ambient atmosphere of the air cleaning device 10 by air.

  Here, the air cleaning device 10 is connected to at least one of the sensor unit 36 that detects the amount of organic substances in the atmosphere, the light irradiation unit 14, and the air blowing unit 16 in a state in which signals can be input and output. Drive control unit 38 is provided. The sensor unit 36 outputs a detection signal to the drive control unit 38 when an organic substance is detected. The drive control part 38 can control at least one of the light irradiation part 14 and the ventilation part 16 based on the detection signal of an organic substance. When controlling the light irradiation part 14, the quantity of the light to irradiate and the time to irradiate light can be controlled. Moreover, you may have the timer function which sets lighting of the light irradiation part 14 to intermittent operation, and complete | finishes irradiation. When controlling the air blower 16, the amount of air to be blown and the time to blow can be controlled. Moreover, you may have the timer function which sets the drive of the ventilation part 16 to intermittent operation, and complete | finishes ventilation.

  Examples of odors detected by the sensor unit 36 include body odors and bad breaths from the human body, alcohol substances, and organic substances produced from pet manure. Moreover, a sensor part is not limited to an odor, For example, house dusts, such as a tick, dust, and pollen can also be detected.

  FIG. 6 is a perspective view showing the configuration of the light shielding member. 7 is a cross-sectional view taken along line AA in FIG. The light shielding members 42 and 44 are formed in substantially rectangular frame bodies 52 and 54 and the frame bodies 52 and 54, respectively, in the direction in which air flows (arrow F in FIG. 6). And a plurality of light shielding plates 52a and 54a for shielding the passage of light. In the present embodiment, the light shielding members 42 and 44 are used in a state where the frame bodies 52 and 54 having the same configuration are overlapped with each other. The plurality of light shielding plates 52 a and 54 a are arranged in parallel with each other at substantially equal intervals, and the light shielding plates 52 a and 54 a communicate with each other from the upstream side to the downstream side, and from the upstream surface of the frame body 52. The inflowing air is allowed to pass out of the downstream surface. The inclination angles I of the plurality of light shielding plates 52a and 54a are all equal, and are preferably in the range of 30 ° to 50 ° with respect to the horizontal direction of the case body 11 (left and right direction in FIG. 7).

  The light shielding members 42 and 44 of the present embodiment are arranged with a plurality of frame bodies 52 and 54 overlapped, and are arranged in a state in which the direction of inclination of the light shielding plates of adjacent frame bodies is opposite. The light shielding members 42 and 44 may be configured by any one of the frame bodies 52 and 54 and a plurality of light shielding plates 52a and 54a formed thereon. At this time, the light shielding member 42 is arranged in a state in which the direction of the inclination of the adjacent light shielding member is opposite.

  FIG. 8 is a partial cross-sectional view showing a modification of the light shielding member of the present embodiment. As shown in FIG. 8, photocatalytic layers 56a and 56b may be formed on the upper and lower surfaces of the light shielding plate 52a. The photocatalyst layers 56a and 56b can have the same configuration as the photocatalyst filters 12a and 12b. For example, the photocatalyst layers may be configured by sticking the photocatalyst filter to the upper and lower surfaces of the light shielding plate 52a. The photocatalyst layers 56a and 56b may be formed only on either the upper surface or the lower surface of the light shielding plate 52a. In this way, the light from the light irradiation unit 14 is irradiated to the light shielding plate 52a, thereby preventing the light from being irradiated downstream by the light shielding plate 52a and the photocatalysts in the photocatalytic layers 56a and 56b of the light shielding plate 52a. Can cause a reaction.

  The present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to these examples.

(Examples 1-2, Comparative Examples 1-3)
In this example, using the prepared nonwoven carrier N-1, the antibody alone and the coating solution-1 to coating solution-5 containing various inorganic silver solutions are prepared, and the antibody and the inorganic silver salt are prepared. Filters F-1 to F-5 were prepared including an antibody filter that was carried and was a hazardous substance removing material according to the present invention. Next, virus inactivation and antibacterial activity were evaluated for these antibody filters, and the results are shown in Table 1.
<Preparation of carrier nonwoven fabric (carrier N-1)>
Acetone: water (97: 3) solution (25% by mass) of cellulose acetate (manufactured by Aldrich, total substitution degree 2.4, number average molecular weight 30,000) is heated to 60 ° C., and from a nozzle having a diameter of 0.1 mm, A nonwoven fabric was formed by jetting together with air at a spinning speed of 500 m / m to obtain a nonwoven fabric carrier N-1 having a thickness of 85 μm. The spinning cylinder was heated to 100 ° C. with a heater. It was 8 micrometers when the average fiber diameter was measured by SEM.

<Preparation of antibody coating solution (coating solution-1 to coating solution-5)>
Coating solution-1: The yolk solution of the immunized egg produced by the chicken administered with the antigen was spray-dried to obtain a dried egg yolk powder. Next, the dried egg yolk powder was degreased with ethanol to remove the degreasing component, and then dried under reduced pressure to obtain a degreased egg yolk powder as an antibody substance. When this defatted egg yolk powder was refine | purified and the purity of the influenza virus antibody (IgY antibody) was measured, it was 3 mass%. Next, a solution prepared by suspending the defatted egg yolk powder in purified water to an antibody concentration of 100 ppm was designated as coating solution-1.
Coating solution-2: A coating solution-2 was prepared by mixing the coating solution-1 with a silver fluoride dispersion and adjusting the silver fluoride concentration to 57 ppm.
Coating solution-3: A coating solution-3 was prepared by mixing the coating solution-1 with a silver chloride dispersion to adjust the silver chloride concentration to 64 ppm (matching the number of moles to silver fluoride).
Coating solution-4: A coating solution-4 was prepared by mixing the coating solution-1 with a silver bromide dispersion and adjusting the silver bromide concentration to 84 ppm (matching the number of moles to silver fluoride).
Coating solution-5: A coating solution-5 was prepared by mixing the coating solution-1 with a silver iodide dispersion and adjusting the silver iodide concentration to 105 ppm (matching the number of moles to silver fluoride).

<Preparation of antibody filter (filter F-1 to filter F-5)>
Filter F-1: Carrier N-1 was immersed in coating solution-1 at room temperature for 5 minutes to give an antibody to the surface of the fiber carrier. The obtained sample was compressed with a roller having a surface pressure of 10 MPa, and the water content was measured and found to be 500%. Furthermore, when it was dried in an atmosphere of 50 ° C. × 30% PH until the water content became 1% or less, the water content reached 1% after 1 hour.
Filters F-2 to F-5: An antibody and an inorganic silver salt were applied to the fiber carrier surface in the same manner as the filter F-1, except that the antibody coating solution-1 was changed to the coating solution-2 to the coating solution-5. The imparted filters F-2 to F-5 were produced.

<Evaluation of virus inactivation efficiency>
For filters F-1 to F-5, virus inactivation efficiency was evaluated immediately after sample preparation. As the test virus solution, purified influenza virus diluted 10 times with PBS (virus concentration 200,000 plaques / ml) was used. Each of the samples was cut into 5 cm squares and attached and fixed in the center of the virus spray test apparatus. The test virus solution was put in a nebulizer installed on the upstream side, and a virus recovery device was attached on the downstream side. Compressed air was sent from an air compressor, and the test virus was sprayed from the nebulizer spray port. A gelatin filter was installed on the downstream side of the mask, and air in the test apparatus was sucked at a suction flow rate of 10 L / min for 5 minutes to collect passing virus mist.
After the test, the gelatin filter collecting the virus was collected, and the virus infectivity after passing through the sample was determined by the TCID50 method (50% cell infectious dose measurement method) using MDCK cells. From the comparison of the virus infectivity value of the gelatin filter with and without the sample, the transient removal rate of the virus of each sample was calculated. The results are shown in Table 1.
Table 1 shows the logarithm of the reciprocal of the solubility product of inorganic silver salt supported on each sample at pH 7 and 25 ° C. = pK _sp .

<Antimicrobial evaluation>
For filters F-1 to F-5, an antibacterial activity test was performed immediately after the production of these filters. The test method was performed in accordance with JIS 2801: 2000. As a test bacterium, Staphylococcus aureus subsp. Aureus NBRC 12732 (Staphylococcus aureus) pre-cultured on a standard agar medium was used. This culture was dispersed and diluted with 1/500 Nutrient broth to prepare a test bacterial solution. 0.4 ml of this test bacterial solution was brought into contact with each filter placed in a sterile petri dish and cultured at 35 ° C. for 24 hours. After culturing, the bacteria were washed from each test cloth with 10 ml of soybean / casein / digest / broth containing lecithin / polysorbate 80, and the number of bacteria in each test cloth was measured by an agar plate culture method. Moreover, when the number of bacteria immediately after contact was measured, it was 1.8 × 10 ⁵ .

As is clear from Table 1, the antibody filter obtained by the production method of the present invention has a high virus removal rate immediately after sample preparation. Moreover, the antibacterial effect and the antifungal effect were provided by the inorganic silver salt. Silver fluoride is a readily soluble silver salt that has high solubility, and it is thought that antibody inactivation by ionization and silver ions occurs and the inactivation efficiency by the antibody decreases. It was considered that silver iodide had a high pK _{sp and} suppressed the sustained release of silver ions, thus reducing the antibacterial effect.

(Examples 3-5, Comparative Examples 4-7)
Each of the antibody filters F-2, F-3, and F-4 and the photocatalyst filter C-1 provided under the same UV irradiation are used, and the light shielding plate is used. After changing the insertion angle from 25 ° to 55 °, flowing the air in the same virus environment and operating the air purifier for 2 weeks, the virus filter transient removal rate (virus Inactivation) and antibacterial activity (the number of bacteria after the test) were evaluated, and the results are shown in Table 2 as evaluations for the antibody filter species of Examples and Comparative Examples and the insertion angle of the light shielding plate.

(Immobilization of antibodies)
An influenza virus antibody (IgY antibody) produced by purifying an immunized egg born by a chicken to which an antigen was administered was dissolved in phosphate buffered saline (PBS) to prepare an antibody concentration of 100 ppm. The sample of the nonwoven fabric N-1 was immersed in the prepared liquid at room temperature for 16 to 24 hours, and an antibody was imparted to the fiber surface. The obtained sample was allowed to stand for 24 hours in an environment of 25 ° C. and 20% RH, and then allowed to stand for 24 hours in an environment of 25 ° C. and 90% RH. This operation was repeated 3 times alternately for a total of 6 conditions.

<Photocatalytic filter>
The photocatalyst filter C-1 attached to the air purification apparatus 10 of an Example and a comparative example was created in the following procedure. A photocatalyst coating agent (TKC-304: manufactured by Teika) is supported on a nonwoven fabric made of polyester / acrylic having a wire diameter of 20 μm and a thickness of 7 mm so as to be 7.5 g per m ² , dried at 100 ° C. for 3 minutes, and photocatalyst filter C -1 was created.

<Installation method of photocatalyst and antibody filter of air purifier>
The above-prepared antibody filters F-2, -3, and -4 are provided on the most downstream side of the air flow, provided with a filter holding unit that creates a frame on the photocatalyst and the antibody filter and is detachably held. A pair of photocatalytic filters was disposed on the side, and a cold cathode tube that efficiently radiates near ultraviolet rays was disposed between them. Three axial fans were arranged at the most downstream as the air blowing section.

(Example 3)
A pair of an antibody filter F-3 and a photocatalyst filter C-1 is arranged, and a light shielding plate (made of ABS which is UV-resistant) 2 at an angle of 30 ° between the antibody filter F-3 and the downstream photocatalyst filter C-1. An air cleaning device 10 with a sheet inserted was used. The light shielding plates were arranged so that the inclination directions were opposite to each other (see FIG. 7).

Example 4
A pair of antibody filter F-4 and photocatalyst filter C-1 is disposed, and two air-shielding plates (made of ABS treated with UV resistance) having an angle of 45 ° are inserted between the antibody filter and the downstream photocatalyst filter. The apparatus 10 was used. The light shielding plates were arranged so that the inclination directions were opposite to each other (see FIG. 7).

(Example 5)
In Example 3, an air purifier was used in which two light shielding plates (made of ABS that had been subjected to UV resistance treatment) having an angle of 50 ° were inserted between the antibody filter F-3 and the downstream photocatalytic filter C-1. The light shielding plates were arranged so that the inclination directions were opposite to each other (see FIG. 7).

(Comparative Example 4)
In Example 4, the air purifier similar to Example 4 was used except having replaced with antibody filter F-2.

(Comparative Example 5)
In Example 3, an air cleaning device was used in which two light shielding plates (made of ABS that had been UV-resistant) of 25 ° were inserted between the antibody filter F-3 and the downstream photocatalytic filter C-1. The light shielding plates were arranged so that the inclination directions were opposite to each other (see FIG. 7).

(Comparative Example 6)
In Example 3, an air purifier was used in which two light shielding plates (made of ABS that had been subjected to UV resistance treatment) having an angle of 55 ° were inserted between the antibody filter F-3 and the downstream photocatalytic filter C-1. The light shielding plates were arranged so that the inclination directions were opposite to each other (see FIG. 7).

(Comparative Example 7)
In Example 3, an air cleaning device without a light shielding plate was used.

<Measurement of air volume>
The amount of air blown in the air under a given virus environment is 26cm in length, 7cm in width, 30cm in length, attached to the outlet, measured at 10 wind speeds (m / s), and the airflow (m ³ / min).

<Evaluation of virus inactivation efficiency (transient removal rate of virus)>
Under the same environment, after operating the air purifier of the said conditions for 2 weeks, the virus inactivation evaluation of each antibody filter was performed.
As the test virus solution, purified influenza virus diluted 10 times with PBS was used. Each of the samples was cut into 5 cm squares and attached and fixed in the center of the virus spray test apparatus. The test virus solution was put in a nebulizer installed on the upstream side, and a virus recovery device was attached on the downstream side. Compressed air was sent from an air compressor, and the test virus was sprayed from the nebulizer spray port. A gelatin filter was installed on the downstream side of the mask, and air in the test apparatus was sucked at a suction flow rate of 10 L / min for 5 minutes to collect passing virus mist. After the test, the gelatin filter collecting the virus was recovered, and the virus infection titer after passing through the sample was determined by the TCID50 method (50% cell infectious dose measurement method) using MDCK cells. From the comparison of the virus infectivity value of the gelatin filter with and without the sample, the transient removal rate of the virus of each sample was calculated.

<Antimicrobial evaluation>
For the antibody filters F-2, F-3, and F-4 of Comparative Examples and Examples, an antibacterial activity test was performed immediately after sample preparation. The test method conformed to JIZ2801: 2000.
As the test bacteria, Staphylococcus aureus subsp. Ureus NBRC 12732 (Staphylococcus aureus) pre-cultured on a standard agar medium was used. The culture was dispersed and diluted with 1/500 neutral broth to prepare a test bacterial solution. 0.4 mL of this test bacterial solution was inoculated into each filter placed in a sterile petri dish, and cultured at 35 ° C. for 24 hours. After culturing, the bacteria were washed from each test cloth with 10 mL of soybean / casein / digest / broth containing lecithin / polysorbate 80, and the number of bacteria in each test cloth was measured by an agar plate culture method. Moreover, when the number of bacteria immediately after inoculation was measured, it was 1.8 × 10 ⁵ . The results are shown in Table 2.

<Deodorization effect evaluation>
The deodorizing effect of the air purifier was evaluated by ammonia concentration.
A closed space (0.2 m ³ ) in which the test was performed The initial ammonia (NH ₃ ) concentration was adjusted to 10 ppm, the air purifier was driven, and the ammonia concentration after 15 minutes was measured with a detector tube.

  The results are shown in Table 2.

As shown in Examples 3 to 5, the UV intensity at the antibody filter can be suppressed to 0 μW / cm ² by setting the angle of inclination of the light shielding plate in the range of 30 ° to 50 °, and 0.5 m ³ It was found that the air volume of / min could be secured and the transient removal rate of the virus was as high as 89 to 91%. Moreover, no bacteria are propagated on the antibody filter due to the action of the specific inorganic silver salt.

It is a figure which shows the structure of one Embodiment of the air purifying apparatus concerning this invention. It is the figure which looked at the air purification apparatus of FIG. 1 from the intake side. It is the figure which looked at the air purification apparatus of FIG. 1 from the exhaust side. It is sectional drawing cut | disconnected by the cross section parallel to the flow path of the air of the air purification apparatus of FIG. It is a block diagram which shows the control system of the air purification apparatus of this embodiment. It is a perspective view which shows the structure of a light-shielding member. It is sectional drawing seen from the AA line direction of FIG. It is a fragmentary sectional view which shows the modification of a light shielding member.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Air cleaning apparatus 11 Case main body 12 (12a, 12b) Photocatalyst filter 14 Light irradiation part 15 Antibody filter 16 Air blower parts 42 and 44 Light shielding member 52a, 54a Light shielding board

Claims (4)

(A) a chicken egg antibody;
(B) an inorganic silver salt having a logarithmic value (pK _sp ) of the reciprocal of the solubility product at pH 7 and 25 ° C. of 8 to 14,
Hazardous substance removal material with carrier supported The harmful substance removing material according to claim 1, wherein the inorganic silver salt is silver chloride or silver bromide.   The harmful substance removing material according to claim 1 or 2, wherein the sphere equivalent diameter of the inorganic silver salt is 0.5 µm or less. A case body having an intake portion for taking air into the interior and an exhaust portion for sending air to the outside;
A photocatalyst filter disposed in the flow path, having a blower part for blowing air to a flow path formed between the intake part and the exhaust part, and a layer containing a photocatalyst;
A light irradiation unit for irradiating light to the photocatalytic filter;
The harmful substance removing material according to any one of claims 1 to 3, which is disposed in the flow path,
A light shielding member is provided between the light irradiation unit and the harmful substance removing agent to allow the air to flow and to block the passage of the light when viewed in the air flowing direction. The member has a frame disposed in the flow path, and a plurality of light shielding plates formed on the frame and arranged in an inclined state at the same angle.

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